E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.015 0.101 -9999.0 0.0 -0.332 25.0 25.0 KLHL20 0.015 0.065 0.178 1.0 -0.27 6.0 7.0 CYFIP2 0.009 0.086 -9999.0 0.0 -0.588 7.0 7.0 Rac1/GDP 0.012 0.077 0.256 2.0 -0.295 1.0 3.0 ENAH -0.015 0.106 -9999.0 0.0 -0.337 27.0 27.0 AP1M1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.013 0.034 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.013 0.039 -9999.0 0.0 -0.196 7.0 7.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.049 0.043 -9999.0 0.0 -0.347 3.0 3.0 RAPGEF1 -0.006 0.093 -9999.0 0.0 -0.436 1.0 1.0 CTNND1 0.024 0.001 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.011 0.11 -9999.0 0.0 -0.345 27.0 27.0 CRK -0.01 0.086 -9999.0 0.0 -0.322 19.0 19.0 E-cadherin/gamma catenin/alpha catenin 0.042 0.027 -9999.0 0.0 -0.377 1.0 1.0 alphaE/beta7 Integrin 0.03 0.037 -9999.0 0.0 -0.437 2.0 2.0 IQGAP1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.042 0.013 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.004 0.073 -9999.0 0.0 -0.336 12.0 12.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.006 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.042 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.004 0.015 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.032 0.027 -9999.0 0.0 -0.437 1.0 1.0 TIAM1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.048 0.028 -9999.0 0.0 -0.327 1.0 1.0 AKT1 0.006 0.029 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.021 0.033 -9999.0 0.0 -0.588 1.0 1.0 RhoA/GDP 0.017 0.073 0.256 2.0 -0.295 1.0 3.0 actin cytoskeleton organization 0.015 0.052 0.165 5.0 -0.193 6.0 11.0 CDC42/GDP 0.015 0.075 0.256 2.0 -0.295 1.0 3.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.015 0.016 -9999.0 0.0 -0.274 1.0 1.0 ITGB7 0.02 0.046 -9999.0 0.0 -0.588 2.0 2.0 RAC1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.052 0.03 -9999.0 0.0 -0.347 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.036 0.024 -9999.0 0.0 -0.325 1.0 1.0 mol:GDP 0.001 0.083 0.263 2.0 -0.323 2.0 4.0 CDC42/GTP/IQGAP1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.023 0.072 0.257 2.0 -0.303 1.0 3.0 RAC1/GTP/IQGAP1 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.021 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.008 0.046 0.132 4.0 -0.24 6.0 10.0 NME1 0.024 0.011 0.227 1.0 -9999.0 0.0 1.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.014 0.106 -9999.0 0.0 -0.337 27.0 27.0 regulation of cell-cell adhesion 0.008 0.029 -9999.0 0.0 -0.218 1.0 1.0 WASF2 0.008 0.028 -9999.0 0.0 -0.141 1.0 1.0 Rap1/GTP 0.018 0.047 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.058 0.044 -9999.0 0.0 -0.33 3.0 3.0 CCND1 0.009 0.055 0.151 4.0 -0.303 6.0 10.0 VAV2 -0.019 0.134 -9999.0 0.0 -0.582 10.0 10.0 RAP1/GDP 0.021 0.061 0.25 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.014 0.103 -9999.0 0.0 -0.328 27.0 27.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.042 0.04 -9999.0 0.0 -0.32 3.0 3.0 E-cadherin/beta catenin 0.01 0.016 -9999.0 0.0 -0.261 1.0 1.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.014 0.103 -9999.0 0.0 -0.338 25.0 25.0 PIK3CA 0.013 0.012 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.018 0.085 -9999.0 0.0 -0.406 9.0 9.0 E-cadherin/beta catenin/alpha catenin 0.041 0.028 -9999.0 0.0 -0.377 1.0 1.0 ITGAE 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.012 0.112 -9999.0 0.0 -0.351 27.0 27.0