Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.178 0.241 -9999.0 0.0 -0.811 19.0 19.0 IHH -0.326 0.327 -9999.0 0.0 -0.623 188.0 188.0 SHH Np/Cholesterol/GAS1 -0.035 0.133 0.191 1.0 -0.351 50.0 51.0 LRPAP1 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.035 0.132 0.349 50.0 -0.189 1.0 51.0 SMO/beta Arrestin2 -0.22 0.231 -9999.0 0.0 -0.419 177.0 177.0 SMO -0.236 0.235 -9999.0 0.0 -0.436 183.0 183.0 AKT1 -0.119 0.164 -9999.0 0.0 -0.582 25.0 25.0 ARRB2 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.233 0.232 -9999.0 0.0 -0.43 183.0 183.0 STIL -0.192 0.198 -9999.0 0.0 -0.51 54.0 54.0 DHH N/PTCH2 -0.005 0.131 -9999.0 0.0 -0.434 28.0 28.0 DHH N/PTCH1 -0.199 0.214 -9999.0 0.0 -0.358 205.0 205.0 PIK3CA 0.013 0.012 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.023 0.161 -9999.0 0.0 -0.588 26.0 26.0 PTHLH -0.22 0.274 -9999.0 0.0 -0.855 18.0 18.0 determination of left/right symmetry -0.233 0.232 -9999.0 0.0 -0.43 183.0 183.0 PIK3R1 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.219 0.272 -9999.0 0.0 -0.844 18.0 18.0 IHH N/Hhip -0.468 0.298 -9999.0 0.0 -0.606 269.0 269.0 DHH N/Hhip -0.293 0.243 -9999.0 0.0 -0.463 221.0 221.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.233 0.232 -9999.0 0.0 -0.43 183.0 183.0 pancreas development -0.352 0.296 -9999.0 0.0 -0.587 211.0 211.0 HHAT 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.017 0.018 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.012 0.08 -9999.0 0.0 -0.588 6.0 6.0 somite specification -0.233 0.232 -9999.0 0.0 -0.43 183.0 183.0 SHH Np/Cholesterol/PTCH1 -0.198 0.208 -9999.0 0.0 -0.468 74.0 74.0 SHH Np/Cholesterol/PTCH2 -0.034 0.129 0.191 1.0 -0.345 49.0 50.0 SHH Np/Cholesterol/Megalin -0.216 0.217 -9999.0 0.0 -0.391 196.0 196.0 SHH -0.052 0.152 0.286 1.0 -0.438 46.0 47.0 catabolic process -0.198 0.217 -9999.0 0.0 -0.378 195.0 195.0 SMO/Vitamin D3 -0.223 0.232 -9999.0 0.0 -0.54 65.0 65.0 SHH Np/Cholesterol/Hhip -0.252 0.208 -9999.0 0.0 -0.391 220.0 220.0 LRP2 -0.301 0.305 -9999.0 0.0 -0.588 183.0 183.0 receptor-mediated endocytosis -0.348 0.273 -9999.0 0.0 -0.605 154.0 154.0 SHH Np/Cholesterol/BOC -0.028 0.117 -9999.0 0.0 -0.344 39.0 39.0 SHH Np/Cholesterol/CDO -0.035 0.131 0.191 1.0 -0.344 51.0 52.0 mesenchymal cell differentiation 0.25 0.206 0.389 220.0 -9999.0 0.0 220.0 mol:Vitamin D3 -0.196 0.213 -9999.0 0.0 -0.498 64.0 64.0 IHH N/PTCH2 -0.203 0.218 -9999.0 0.0 -0.395 189.0 189.0 CDON 0.014 0.073 -9999.0 0.0 -0.588 5.0 5.0 IHH N/PTCH1 -0.192 0.229 -9999.0 0.0 -0.382 195.0 195.0 Megalin/LRPAP1 -0.215 0.232 -9999.0 0.0 -0.431 184.0 184.0 PTCH2 0.018 0.058 0.227 1.0 -0.588 3.0 4.0 SHH Np/Cholesterol -0.039 0.12 -9999.0 0.0 -0.342 46.0 46.0 PTCH1 -0.199 0.218 -9999.0 0.0 -0.379 195.0 195.0 HHIP -0.352 0.296 -9999.0 0.0 -0.588 211.0 211.0