Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.018 0.017 -9999.0 0.0 -0.268 1.0 1.0 epithelial cell differentiation 0.044 0.026 -9999.0 0.0 -0.324 1.0 1.0 CYFIP2 0.009 0.086 -9999.0 0.0 -0.588 7.0 7.0 ENAH 0.007 0.067 0.25 7.0 -9999.0 0.0 7.0 EGFR 0.019 0.096 0.387 7.0 -0.588 6.0 13.0 EPHA2 0.017 0.057 -9999.0 0.0 -0.588 3.0 3.0 MYO6 -0.007 0.03 -9999.0 0.0 -0.314 1.0 1.0 CTNNB1 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.033 0.059 -9999.0 0.0 -0.374 6.0 6.0 AQP5 -0.136 0.23 -9999.0 0.0 -0.495 98.0 98.0 CTNND1 0.024 0.001 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.008 0.028 -9999.0 0.0 -0.309 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.092 0.14 -9999.0 0.0 -0.312 97.0 97.0 EGF 0.009 0.093 0.227 1.0 -0.588 8.0 9.0 NCKAP1 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.064 0.178 -9999.0 0.0 -0.494 49.0 49.0 cortical microtubule organization 0.044 0.026 -9999.0 0.0 -0.324 1.0 1.0 GO:0000145 -0.008 0.026 0.161 4.0 -0.296 1.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.048 0.028 -9999.0 0.0 -0.328 1.0 1.0 MLLT4 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.018 0.03 -9999.0 0.0 -0.29 3.0 3.0 ARF6 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.045 0.044 -9999.0 0.0 -0.347 3.0 3.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.0 0.016 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.007 0.029 -9999.0 0.0 -0.314 1.0 1.0 ARF6/GTP 0.047 0.046 -9999.0 0.0 -0.326 3.0 3.0 CDH1 0.021 0.033 -9999.0 0.0 -0.588 1.0 1.0 EGFR/EGFR/EGF/EGF 0.024 0.077 -9999.0 0.0 -0.328 14.0 14.0 RhoA/GDP 0.044 0.027 -9999.0 0.0 -0.311 1.0 1.0 actin cytoskeleton organization -0.009 0.025 -9999.0 0.0 -0.294 1.0 1.0 IGF-1R heterotetramer 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.015 0.074 0.227 1.0 -0.588 5.0 6.0 DIAPH1 -0.021 0.175 -9999.0 0.0 -0.608 10.0 10.0 Wnt receptor signaling pathway -0.044 0.026 0.324 1.0 -9999.0 0.0 1.0 RHOA 0.021 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.018 0.031 -9999.0 0.0 -0.288 4.0 4.0 CTNNA1 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.009 0.025 -9999.0 0.0 -0.3 1.0 1.0 EFNA1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.006 0.017 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 0.034 0.041 -9999.0 0.0 -0.309 4.0 4.0 SEC6/SEC8 -0.014 0.018 -9999.0 0.0 -0.296 1.0 1.0 MGAT3 -0.093 0.142 -9999.0 0.0 -0.317 97.0 97.0 HGF/MET -0.018 0.13 -9999.0 0.0 -0.306 56.0 56.0 HGF -0.076 0.225 -9999.0 0.0 -0.588 56.0 56.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.018 0.017 -9999.0 0.0 -0.269 1.0 1.0 actin cable formation 0.043 0.097 0.297 17.0 -9999.0 0.0 17.0 KIAA1543 -0.007 0.029 -9999.0 0.0 -0.3 1.0 1.0 KIFC3 -0.009 0.027 -9999.0 0.0 -0.314 1.0 1.0 NCK1 0.021 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.019 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.008 0.029 -9999.0 0.0 -0.297 1.0 1.0 NCK1/GIT1 0.03 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.044 0.026 -9999.0 0.0 -0.324 1.0 1.0 EXOC4 0.023 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.007 0.03 -9999.0 0.0 -0.314 1.0 1.0 PIP5K1C -0.008 0.028 -9999.0 0.0 -0.314 1.0 1.0 LIMA1 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.016 0.083 0.302 10.0 -9999.0 0.0 10.0 adherens junction assembly -0.01 0.079 0.259 1.0 -0.674 3.0 4.0 IGF-1R heterotetramer/IGF1 0.034 0.048 -9999.0 0.0 -0.301 6.0 6.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.033 0.009 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.02 0.051 0.387 1.0 -0.588 2.0 3.0 PLEKHA7 -0.007 0.03 -9999.0 0.0 -0.314 1.0 1.0 mol:GTP 0.043 0.044 -9999.0 0.0 -0.345 3.0 3.0 establishment of epithelial cell apical/basal polarity 0.027 0.087 0.352 6.0 -9999.0 0.0 6.0 cortical actin cytoskeleton stabilization 0.018 0.017 -9999.0 0.0 -0.268 1.0 1.0 regulation of cell-cell adhesion -0.009 0.025 -9999.0 0.0 -0.294 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.018 0.017 -9999.0 0.0 -0.269 1.0 1.0