E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.028 0.138 -9999.0 0.0 -0.4 14.0 14.0 KLHL20 -0.006 0.111 0.257 1.0 -0.302 10.0 11.0 CYFIP2 0.026 0.047 -9999.0 0.0 -0.508 1.0 1.0 Rac1/GDP -0.001 0.105 -9999.0 0.0 -0.297 1.0 1.0 ENAH -0.028 0.143 -9999.0 0.0 -0.4 16.0 16.0 AP1M1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.026 0.062 -9999.0 0.0 -0.508 2.0 2.0 CTNNB1 0.03 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.01 0.078 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.032 0.059 -9999.0 0.0 -0.202 10.0 10.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.084 -9999.0 0.0 -0.288 7.0 7.0 RAPGEF1 -0.019 0.13 -9999.0 0.0 -0.417 7.0 7.0 CTNND1 0.017 0.096 -9999.0 0.0 -0.508 5.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.023 0.15 -9999.0 0.0 -0.409 16.0 16.0 CRK -0.015 0.134 -9999.0 0.0 -0.406 11.0 11.0 E-cadherin/gamma catenin/alpha catenin 0.019 0.125 -9999.0 0.0 -0.334 16.0 16.0 alphaE/beta7 Integrin 0.047 0.013 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.027 0.047 -9999.0 0.0 -0.508 1.0 1.0 Rap1/GTP/I-afadin 0.055 0.044 -9999.0 0.0 -0.288 2.0 2.0 DLG1 -0.019 0.111 -9999.0 0.0 -0.391 8.0 8.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.01 0.044 -9999.0 0.0 -0.253 2.0 2.0 MLLT4 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.057 0.045 -9999.0 0.0 -0.288 2.0 2.0 PI3K -0.011 0.057 -9999.0 0.0 -0.334 2.0 2.0 ARF6 0.026 0.062 -9999.0 0.0 -0.508 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.0 0.136 -9999.0 0.0 -0.389 16.0 16.0 TIAM1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.041 0.097 -9999.0 0.0 -0.272 12.0 12.0 AKT1 0.006 0.057 0.148 2.0 -0.213 4.0 6.0 PIK3R1 0.006 0.099 -9999.0 0.0 -0.508 5.0 5.0 CDH1 0.007 0.113 -9999.0 0.0 -0.508 7.0 7.0 RhoA/GDP 0.004 0.104 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.002 0.082 0.215 1.0 -0.213 10.0 11.0 CDC42/GDP 0.002 0.106 0.25 1.0 -0.292 2.0 3.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.015 0.102 -9999.0 0.0 -0.267 20.0 20.0 ITGB7 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.045 0.104 -9999.0 0.0 -0.289 12.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.036 0.071 -9999.0 0.0 -0.268 7.0 7.0 mol:GDP -0.015 0.111 -9999.0 0.0 -0.328 4.0 4.0 CDC42/GTP/IQGAP1 0.044 0.01 -9999.0 0.0 -9999.0 0.0 0.0 JUP -0.002 0.134 -9999.0 0.0 -0.508 10.0 10.0 p120 catenin/RhoA/GDP 0.007 0.113 -9999.0 0.0 -0.295 1.0 1.0 RAC1/GTP/IQGAP1 0.044 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.044 0.037 -9999.0 0.0 -0.37 1.0 1.0 RHOA 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.007 0.077 0.165 1.0 -0.228 12.0 13.0 NME1 0.034 0.003 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.03 0.143 -9999.0 0.0 -0.4 16.0 16.0 regulation of cell-cell adhesion -0.002 0.062 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.004 0.047 -9999.0 0.0 -0.14 6.0 6.0 Rap1/GTP 0.01 0.086 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.046 0.123 -9999.0 0.0 -0.289 16.0 16.0 CCND1 -0.01 0.095 0.188 1.0 -0.287 12.0 13.0 VAV2 -0.043 0.229 -9999.0 0.0 -0.633 14.0 14.0 RAP1/GDP 0.013 0.096 0.266 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.029 0.139 -9999.0 0.0 -0.388 16.0 16.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.028 0.046 -9999.0 0.0 -0.508 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.025 0.111 -9999.0 0.0 -0.282 15.0 15.0 E-cadherin/beta catenin -0.004 0.083 -9999.0 0.0 -0.349 8.0 8.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.031 0.142 -9999.0 0.0 -0.4 16.0 16.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.508 2.0 2.0 Rac1/GTP -0.064 0.156 -9999.0 0.0 -0.499 12.0 12.0 E-cadherin/beta catenin/alpha catenin 0.041 0.083 -9999.0 0.0 -0.315 7.0 7.0 ITGAE 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.024 0.153 -9999.0 0.0 -0.418 16.0 16.0