Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.136 0.275 -9999.0 0.0 -0.566 42.0 42.0 IHH -0.014 0.09 -9999.0 0.0 -0.535 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.042 0.141 -9999.0 0.0 -0.324 28.0 28.0 LRPAP1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.042 0.14 0.322 28.0 -9999.0 0.0 28.0 SMO/beta Arrestin2 -0.116 0.237 -9999.0 0.0 -0.589 20.0 20.0 SMO -0.131 0.24 -9999.0 0.0 -0.604 21.0 21.0 AKT1 -0.073 0.219 -9999.0 0.0 -0.722 12.0 12.0 ARRB2 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.023 0.026 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.129 0.236 -9999.0 0.0 -0.593 21.0 21.0 STIL -0.077 0.158 -9999.0 0.0 -0.458 11.0 11.0 DHH N/PTCH2 0.049 0.011 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.05 0.163 -9999.0 0.0 -0.303 41.0 41.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.508 2.0 2.0 DHH 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.251 0.449 -9999.0 0.0 -0.956 43.0 43.0 determination of left/right symmetry -0.129 0.236 -9999.0 0.0 -0.593 21.0 21.0 PIK3R1 0.006 0.099 -9999.0 0.0 -0.508 5.0 5.0 skeletal system development -0.247 0.442 -9999.0 0.0 -0.942 43.0 43.0 IHH N/Hhip -0.054 0.157 -9999.0 0.0 -0.421 21.0 21.0 DHH N/Hhip -0.023 0.136 -9999.0 0.0 -0.37 19.0 19.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.129 0.236 -9999.0 0.0 -0.593 21.0 21.0 pancreas development -0.057 0.179 -9999.0 0.0 -0.507 20.0 20.0 HHAT -0.005 0.14 -9999.0 0.0 -0.508 11.0 11.0 PI3K 0.004 0.075 -9999.0 0.0 -0.37 5.0 5.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.051 0.184 -9999.0 0.0 -0.508 21.0 21.0 somite specification -0.129 0.236 -9999.0 0.0 -0.593 21.0 21.0 SHH Np/Cholesterol/PTCH1 -0.069 0.164 -9999.0 0.0 -0.381 18.0 18.0 SHH Np/Cholesterol/PTCH2 0.008 0.086 -9999.0 0.0 -0.287 12.0 12.0 SHH Np/Cholesterol/Megalin 0.002 0.091 -9999.0 0.0 -0.293 13.0 13.0 SHH -0.013 0.104 -9999.0 0.0 -0.37 12.0 12.0 catabolic process -0.069 0.173 -9999.0 0.0 -0.339 42.0 42.0 SMO/Vitamin D3 -0.103 0.205 -9999.0 0.0 -0.518 19.0 19.0 SHH Np/Cholesterol/Hhip -0.043 0.127 -9999.0 0.0 -0.297 29.0 29.0 LRP2 0.022 0.052 -9999.0 0.0 -0.508 1.0 1.0 receptor-mediated endocytosis -0.102 0.196 -9999.0 0.0 -0.507 18.0 18.0 SHH Np/Cholesterol/BOC 0.0 0.086 -9999.0 0.0 -0.287 12.0 12.0 SHH Np/Cholesterol/CDO 0.007 0.087 -9999.0 0.0 -0.289 12.0 12.0 mesenchymal cell differentiation 0.043 0.126 0.295 29.0 -9999.0 0.0 29.0 mol:Vitamin D3 -0.069 0.164 -9999.0 0.0 -0.381 18.0 18.0 IHH N/PTCH2 0.016 0.062 -9999.0 0.0 -0.324 1.0 1.0 CDON 0.03 0.02 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.062 0.18 -9999.0 0.0 -0.341 42.0 42.0 Megalin/LRPAP1 0.034 0.045 -9999.0 0.0 -0.37 1.0 1.0 PTCH2 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.004 0.082 -9999.0 0.0 -0.285 12.0 12.0 PTCH1 -0.069 0.173 -9999.0 0.0 -0.34 42.0 42.0 HHIP -0.057 0.179 -9999.0 0.0 -0.508 20.0 20.0