Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.014 0.111 -9999.0 0.0 -0.295 17.0 17.0 epithelial cell differentiation 0.036 0.094 -9999.0 0.0 -0.269 12.0 12.0 CYFIP2 0.026 0.047 -9999.0 0.0 -0.508 1.0 1.0 ENAH -0.014 0.108 0.278 3.0 -0.332 6.0 9.0 EGFR -0.031 0.169 -9999.0 0.0 -0.508 17.0 17.0 EPHA2 -0.01 0.14 -9999.0 0.0 -0.508 11.0 11.0 MYO6 -0.011 0.092 -9999.0 0.0 -0.283 14.0 14.0 CTNNB1 0.03 0.016 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.052 0.052 -9999.0 0.0 -0.317 2.0 2.0 AQP5 -0.063 0.173 -9999.0 0.0 -0.48 20.0 20.0 CTNND1 0.017 0.096 -9999.0 0.0 -0.508 5.0 5.0 mol:PI-4-5-P2 -0.007 0.08 -9999.0 0.0 -0.255 13.0 13.0 regulation of calcium-dependent cell-cell adhesion -0.026 0.103 -9999.0 0.0 -0.284 19.0 19.0 EGF -0.031 0.15 -9999.0 0.0 -0.508 13.0 13.0 NCKAP1 0.027 0.047 -9999.0 0.0 -0.508 1.0 1.0 AQP3 -0.098 0.193 -9999.0 0.0 -0.474 29.0 29.0 cortical microtubule organization 0.036 0.094 -9999.0 0.0 -0.269 12.0 12.0 GO:0000145 -0.027 0.071 -9999.0 0.0 -0.244 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.041 0.097 -9999.0 0.0 -0.272 12.0 12.0 MLLT4 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.056 0.109 -9999.0 0.0 -0.427 8.0 8.0 ARF6 0.026 0.062 -9999.0 0.0 -0.508 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.027 0.121 -9999.0 0.0 -0.361 11.0 11.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.019 0.07 -9999.0 0.0 -0.32 3.0 3.0 PVRL2 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.011 0.082 -9999.0 0.0 -0.259 14.0 14.0 ARF6/GTP 0.028 0.129 -9999.0 0.0 -0.352 12.0 12.0 CDH1 0.007 0.113 -9999.0 0.0 -0.508 7.0 7.0 EGFR/EGFR/EGF/EGF -0.041 0.153 -9999.0 0.0 -0.314 32.0 32.0 RhoA/GDP 0.038 0.091 -9999.0 0.0 -0.256 12.0 12.0 actin cytoskeleton organization -0.035 0.095 -9999.0 0.0 -0.311 13.0 13.0 IGF-1R heterotetramer -0.006 0.139 -9999.0 0.0 -0.507 11.0 11.0 GIT1 0.026 0.062 -9999.0 0.0 -0.508 2.0 2.0 IGF1R -0.006 0.14 -9999.0 0.0 -0.508 11.0 11.0 IGF1 -0.048 0.181 -9999.0 0.0 -0.508 20.0 20.0 DIAPH1 0.006 0.187 -9999.0 0.0 -0.621 7.0 7.0 Wnt receptor signaling pathway -0.036 0.094 0.269 12.0 -9999.0 0.0 12.0 RHOA 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.053 0.101 -9999.0 0.0 -0.418 7.0 7.0 CTNNA1 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.036 0.098 -9999.0 0.0 -0.319 13.0 13.0 EFNA1 0.021 0.076 -9999.0 0.0 -0.508 3.0 3.0 LPP -0.023 0.062 -9999.0 0.0 -0.257 9.0 9.0 Ephrin A1/EPHA2 0.002 0.129 -9999.0 0.0 -0.306 20.0 20.0 SEC6/SEC8 -0.005 0.065 -9999.0 0.0 -0.253 9.0 9.0 MGAT3 -0.027 0.105 -9999.0 0.0 -0.288 19.0 19.0 HGF/MET 0.023 0.093 -9999.0 0.0 -0.257 13.0 13.0 HGF 0.03 0.019 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.014 0.112 -9999.0 0.0 -0.297 17.0 17.0 actin cable formation 0.035 0.128 0.304 8.0 -0.297 4.0 12.0 KIAA1543 -0.026 0.07 -9999.0 0.0 -0.249 12.0 12.0 KIFC3 -0.004 0.076 -9999.0 0.0 -0.261 11.0 11.0 NCK1 0.021 0.062 -9999.0 0.0 -0.508 2.0 2.0 EXOC3 0.028 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.006 0.08 -9999.0 0.0 -0.263 12.0 12.0 NCK1/GIT1 0.03 0.062 -9999.0 0.0 -0.37 3.0 3.0 mol:GDP 0.036 0.094 -9999.0 0.0 -0.269 12.0 12.0 EXOC4 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.002 0.074 -9999.0 0.0 -0.261 10.0 10.0 PIP5K1C -0.007 0.081 -9999.0 0.0 -0.259 13.0 13.0 LIMA1 0.005 0.12 -9999.0 0.0 -0.508 8.0 8.0 ABI1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.011 0.129 0.291 5.0 -0.391 6.0 11.0 adherens junction assembly -0.019 0.106 -9999.0 0.0 -0.463 4.0 4.0 IGF-1R heterotetramer/IGF1 -0.038 0.15 -9999.0 0.0 -0.289 36.0 36.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.047 0.018 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.021 0.076 -9999.0 0.0 -0.508 3.0 3.0 PLEKHA7 -0.005 0.079 -9999.0 0.0 -0.261 12.0 12.0 mol:GTP 0.025 0.119 -9999.0 0.0 -0.358 11.0 11.0 establishment of epithelial cell apical/basal polarity 0.012 0.111 0.359 5.0 -9999.0 0.0 5.0 cortical actin cytoskeleton stabilization -0.014 0.111 -9999.0 0.0 -0.295 17.0 17.0 regulation of cell-cell adhesion -0.035 0.095 -9999.0 0.0 -0.311 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.014 0.112 -9999.0 0.0 -0.297 17.0 17.0