E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.047 0.101 -9999.0 0.0 -0.324 62.0 62.0 KLHL20 -0.058 0.077 0.476 1.0 -0.272 17.0 18.0 CYFIP2 0.028 0.006 -9999.0 0.0 0.0 24.0 24.0 Rac1/GDP -0.046 0.078 0.245 4.0 -0.266 11.0 15.0 ENAH -0.048 0.102 -9999.0 0.0 -0.322 64.0 64.0 AP1M1 0.026 0.01 -9999.0 0.0 0.0 67.0 67.0 RAP1B 0.028 0.006 -9999.0 0.0 0.0 22.0 22.0 RAP1A 0.029 0.003 -9999.0 0.0 0.0 7.0 7.0 CTNNB1 0.028 0.007 -9999.0 0.0 -0.013 13.0 13.0 CDC42/GTP -0.059 0.05 0.115 24.0 -0.233 2.0 26.0 ABI1/Sra1/Nap1 -0.053 0.045 -9999.0 0.0 -0.169 33.0 33.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.055 0.047 -9999.0 0.0 -0.141 9.0 9.0 RAPGEF1 -0.047 0.098 0.249 3.0 -0.307 54.0 57.0 CTNND1 0.029 0.004 -9999.0 0.0 -0.005 6.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.024 0.113 -9999.0 0.0 -0.323 66.0 66.0 CRK -0.047 0.101 -9999.0 0.0 -0.317 59.0 59.0 E-cadherin/gamma catenin/alpha catenin 0.043 0.044 -9999.0 0.0 -0.156 20.0 20.0 alphaE/beta7 Integrin 0.04 0.014 -9999.0 0.0 -0.163 1.0 1.0 IQGAP1 0.028 0.006 -9999.0 0.0 0.0 25.0 25.0 NCKAP1 0.028 0.005 -9999.0 0.0 0.0 17.0 17.0 Rap1/GTP/I-afadin 0.04 0.042 -9999.0 0.0 -0.131 21.0 21.0 DLG1 -0.033 0.102 0.193 1.0 -0.324 52.0 53.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.044 0.042 -9999.0 0.0 -0.163 7.0 7.0 MLLT4 0.026 0.01 -9999.0 0.0 0.0 70.0 70.0 ARF6/GTP/NME1/Tiam1 0.048 0.024 -9999.0 0.0 -0.13 1.0 1.0 PI3K -0.054 0.054 -9999.0 0.0 -0.212 6.0 6.0 ARF6 0.029 0.004 -9999.0 0.0 0.0 11.0 11.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.03 0.042 -9999.0 0.0 -0.176 19.0 19.0 TIAM1 0.028 0.006 -9999.0 0.0 -0.001 21.0 21.0 E-cadherin(dimer)/Ca2+ 0.052 0.043 -9999.0 0.0 -0.132 9.0 9.0 AKT1 -0.013 0.07 0.136 53.0 -9999.0 0.0 53.0 PIK3R1 0.021 0.013 -9999.0 0.0 0.0 159.0 159.0 CDH1 0.025 0.011 -9999.0 0.0 -0.002 77.0 77.0 RhoA/GDP -0.045 0.077 0.237 4.0 -0.265 11.0 15.0 actin cytoskeleton organization -0.043 0.058 0.412 1.0 -0.215 8.0 9.0 CDC42/GDP -0.045 0.078 0.237 5.0 -0.263 12.0 17.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.015 0.058 -9999.0 0.0 -0.188 36.0 36.0 ITGB7 0.029 0.004 -9999.0 0.0 0.0 9.0 9.0 RAC1 0.028 0.007 -9999.0 0.0 -0.001 28.0 28.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.056 0.046 -9999.0 0.0 -0.142 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.039 0.033 -9999.0 0.0 -0.121 9.0 9.0 mol:GDP -0.044 0.084 0.249 4.0 -0.281 18.0 22.0 CDC42/GTP/IQGAP1 0.037 0.014 -9999.0 0.0 -0.134 2.0 2.0 JUP 0.027 0.008 -9999.0 0.0 0.0 42.0 42.0 p120 catenin/RhoA/GDP -0.048 0.081 0.242 4.0 -0.271 10.0 14.0 RAC1/GTP/IQGAP1 0.036 0.015 -9999.0 0.0 -0.134 2.0 2.0 PIP5K1C/AP1M1 0.036 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.003 -9999.0 0.0 0.0 6.0 6.0 CDC42 0.029 0.004 -9999.0 0.0 0.0 11.0 11.0 CTNNA1 0.029 0.005 -9999.0 0.0 -0.002 12.0 12.0 positive regulation of S phase of mitotic cell cycle -0.045 0.056 0.115 1.0 -0.129 145.0 146.0 NME1 0.027 0.008 -9999.0 0.0 0.0 43.0 43.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.048 0.104 -9999.0 0.0 -0.323 66.0 66.0 regulation of cell-cell adhesion -0.055 0.041 0.082 23.0 -0.206 2.0 25.0 WASF2 -0.031 0.035 0.085 5.0 -0.101 41.0 46.0 Rap1/GTP -0.055 0.057 0.154 22.0 -0.252 2.0 24.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.063 -9999.0 0.0 -0.151 20.0 20.0 CCND1 -0.055 0.069 0.131 1.0 -0.158 145.0 146.0 VAV2 -0.039 0.163 -9999.0 0.0 -0.638 25.0 25.0 RAP1/GDP -0.047 0.065 0.253 3.0 -0.254 3.0 6.0 adherens junction assembly -0.047 0.101 -9999.0 0.0 -0.314 66.0 66.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.005 -9999.0 0.0 0.0 15.0 15.0 PIP5K1C 0.027 0.008 -9999.0 0.0 0.0 43.0 43.0 regulation of heterotypic cell-cell adhesion -0.06 0.03 0.171 4.0 -0.229 2.0 6.0 E-cadherin/beta catenin -0.022 0.046 -9999.0 0.0 -0.18 40.0 40.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.046 0.101 -9999.0 0.0 -0.326 60.0 60.0 PIK3CA 0.02 0.014 -9999.0 0.0 0.0 172.0 172.0 Rac1/GTP -0.089 0.111 0.567 1.0 -0.384 36.0 37.0 E-cadherin/beta catenin/alpha catenin 0.048 0.032 -9999.0 0.0 -0.146 9.0 9.0 ITGAE 0.028 0.007 -9999.0 0.0 0.0 30.0 30.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.024 0.115 -9999.0 0.0 -0.329 66.0 66.0