Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.079 0.245 -9999.0 0.0 -0.707 1.0 1.0 IHH -0.19 0.391 -9999.0 0.0 -0.909 9.0 9.0 SHH Np/Cholesterol/GAS1 -0.158 0.285 -9999.0 0.0 -0.632 10.0 10.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.156 0.282 0.626 10.0 -9999.0 0.0 10.0 SMO/beta Arrestin2 -0.082 0.235 -9999.0 0.0 -0.702 1.0 1.0 SMO -0.093 0.247 -9999.0 0.0 -0.747 1.0 1.0 AKT1 -0.017 0.111 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.092 0.243 -9999.0 0.0 -0.731 1.0 1.0 STIL -0.151 0.303 -9999.0 0.0 -0.776 4.0 4.0 DHH N/PTCH2 -0.111 0.265 -9999.0 0.0 -0.74 6.0 6.0 DHH N/PTCH1 -0.187 0.269 -9999.0 0.0 -0.693 5.0 5.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.106 0.315 -9999.0 0.0 -0.936 5.0 5.0 PTHLH -0.086 0.263 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry -0.092 0.243 -9999.0 0.0 -0.731 1.0 1.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.085 0.261 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip -0.248 0.427 -9999.0 0.0 -0.814 13.0 13.0 DHH N/Hhip -0.219 0.364 -9999.0 0.0 -0.795 11.0 11.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.092 0.243 -9999.0 0.0 -0.731 1.0 1.0 pancreas development -0.154 0.364 -9999.0 0.0 -0.942 7.0 7.0 HHAT 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.053 0.233 -9999.0 0.0 -0.867 3.0 3.0 somite specification -0.092 0.243 -9999.0 0.0 -0.731 1.0 1.0 SHH Np/Cholesterol/PTCH1 -0.206 0.292 -9999.0 0.0 -0.829 4.0 4.0 SHH Np/Cholesterol/PTCH2 -0.133 0.282 -9999.0 0.0 -0.719 6.0 6.0 SHH Np/Cholesterol/Megalin -0.285 0.345 -9999.0 0.0 -0.739 10.0 10.0 SHH -0.126 0.303 -9999.0 0.0 -0.73 8.0 8.0 catabolic process -0.088 0.243 -9999.0 0.0 -0.584 6.0 6.0 SMO/Vitamin D3 -0.159 0.318 -9999.0 0.0 -0.802 4.0 4.0 SHH Np/Cholesterol/Hhip -0.223 0.319 -9999.0 0.0 -0.638 14.0 14.0 LRP2 -0.259 0.416 -9999.0 0.0 -0.892 12.0 12.0 receptor-mediated endocytosis -0.284 0.326 -9999.0 0.0 -0.826 8.0 8.0 SHH Np/Cholesterol/BOC -0.118 0.238 -9999.0 0.0 -0.591 8.0 8.0 SHH Np/Cholesterol/CDO -0.149 0.286 -9999.0 0.0 -0.681 8.0 8.0 mesenchymal cell differentiation 0.221 0.315 0.631 14.0 -9999.0 0.0 14.0 mol:Vitamin D3 -0.167 0.321 -9999.0 0.0 -0.829 4.0 4.0 IHH N/PTCH2 -0.14 0.292 -9999.0 0.0 -0.637 10.0 10.0 CDON -0.036 0.213 -9999.0 0.0 -0.966 2.0 2.0 IHH N/PTCH1 -0.091 0.246 -9999.0 0.0 -0.593 6.0 6.0 Megalin/LRPAP1 -0.208 0.32 -9999.0 0.0 -0.694 12.0 12.0 PTCH2 -0.012 0.153 -9999.0 0.0 -0.966 1.0 1.0 SHH Np/Cholesterol -0.12 0.241 -9999.0 0.0 -0.6 8.0 8.0 PTCH1 -0.089 0.244 -9999.0 0.0 -0.586 6.0 6.0 HHIP -0.155 0.364 -9999.0 0.0 -0.945 7.0 7.0