Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	10.0	504.0	46.0	-1.036	0.037	1000.0	-1000.0	-0.163	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	6.0	207.0	34.0	-0.394	0.013	1000.0	-1000.0	-0.116	-1000.0
EGFR-dependent Endothelin signaling events	6.0	132.0	21.0	-0.513	0.013	1000.0	-1000.0	-0.121	-1000.0
Ephrin A  reverse signaling	5.0	35.0	7.0	-0.099	-0.0	1000.0	-1000.0	-0.06	-1000.0
HIF-1-alpha transcription factor network	5.0	447.0	76.0	-0.702	0.021	1000.0	-1000.0	-0.248	-1000.0
IL4-mediated signaling events	5.0	511.0	91.0	-0.792	0.731	1000.0	-1000.0	-0.229	-1000.0
IL23-mediated signaling events	5.0	312.0	60.0	-0.604	0.013	1000.0	-1000.0	-0.244	-1000.0
Signaling events mediated by the Hedgehog family	4.0	248.0	52.0	-0.285	0.221	1000.0	-1000.0	-0.149	-1000.0
Reelin signaling pathway	4.0	238.0	56.0	-0.337	0.013	1000.0	-1000.0	-0.141	-1000.0
Wnt signaling	4.0	30.0	7.0	-0.356	0.013	1000.0	-1000.0	-0.054	-1000.0
BCR signaling pathway	4.0	411.0	99.0	-0.487	0.013	1000.0	-1000.0	-0.169	-1000.0
Visual signal transduction: Cones	3.0	137.0	38.0	-0.275	0.013	1000.0	-1000.0	-0.114	-1000.0
Signaling events mediated by PTP1B	3.0	254.0	76.0	-0.514	0.099	1000.0	-1000.0	-0.141	-1000.0
p75(NTR)-mediated signaling	3.0	498.0	125.0	-0.422	0.013	1000.0	-1000.0	-0.178	-1000.0
Glypican 1 network	3.0	184.0	48.0	-0.543	0.037	1000.0	-1000.0	-0.085	-1000.0
amb2 Integrin signaling	3.0	264.0	82.0	-0.265	0.013	1000.0	-1000.0	-0.146	-1000.0
Glucocorticoid receptor regulatory network	3.0	417.0	114.0	-0.812	0.326	1000.0	-1000.0	-0.139	-1000.0
Signaling events regulated by Ret tyrosine kinase	3.0	292.0	82.0	-0.225	0.013	1000.0	-1000.0	-0.134	-1000.0
TCR signaling in naïve CD8+ T cells	3.0	290.0	93.0	-0.2	0.075	1000.0	-1000.0	-0.143	-1000.0
Effects of Botulinum toxin	3.0	80.0	26.0	-0.214	0.013	1000.0	-1000.0	-0.11	-1000.0
Calcium signaling in the CD4+ TCR pathway	3.0	93.0	31.0	-0.438	0.013	1000.0	-1000.0	-0.184	-1000.0
IL6-mediated signaling events	3.0	274.0	75.0	-0.658	0.049	1000.0	-1000.0	-0.15	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	3.0	206.0	68.0	-0.54	0.124	1000.0	-1000.0	-0.222	-1000.0
TCGA08_retinoblastoma	3.0	30.0	8.0	-0.195	0.052	1000.0	-1000.0	-0.043	-1000.0
Visual signal transduction: Rods	3.0	197.0	52.0	-0.485	0.013	1000.0	-1000.0	-0.159	-1000.0
IL12-mediated signaling events	2.0	237.0	87.0	-0.312	0.033	1000.0	-1000.0	-0.204	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	134.0	54.0	-0.317	0.025	1000.0	-1000.0	-0.179	-1000.0
Noncanonical Wnt signaling pathway	2.0	64.0	26.0	-0.356	0.013	1000.0	-1000.0	-0.158	-1000.0
Arf6 signaling events	2.0	144.0	62.0	-0.513	0.014	1000.0	-1000.0	-0.107	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	148.0	52.0	-0.479	0.056	1000.0	-1000.0	-0.117	-1000.0
Endothelins	2.0	193.0	96.0	-0.289	0.056	1000.0	-1000.0	-0.148	-1000.0
Syndecan-3-mediated signaling events	2.0	76.0	35.0	-0.189	0.013	1000.0	-1000.0	-0.12	-1000.0
Signaling mediated by p38-alpha and p38-beta	2.0	112.0	44.0	-0.22	0.013	1000.0	-1000.0	-0.076	-1000.0
IL27-mediated signaling events	2.0	104.0	51.0	-0.304	0.056	1000.0	-1000.0	-0.168	-1000.0
Syndecan-4-mediated signaling events	2.0	163.0	67.0	-0.313	0.048	1000.0	-1000.0	-0.169	-1000.0
IGF1 pathway	2.0	118.0	57.0	-0.299	0.064	1000.0	-1000.0	-0.173	-1000.0
Insulin Pathway	2.0	219.0	74.0	-0.508	0.029	1000.0	-1000.0	-0.161	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	2.0	279.0	120.0	-0.47	0.208	1000.0	-1000.0	-0.151	-1000.0
Class IB PI3K non-lipid kinase events	2.0	6.0	3.0	-0.032	-1000.0	1000.0	-1000.0	-0.03	-1000.0
Caspase cascade in apoptosis	1.0	75.0	74.0	-0.087	0.035	1000.0	-1000.0	-0.087	-1000.0
ErbB4 signaling events	1.0	134.0	69.0	-0.384	0.172	1000.0	-1000.0	-0.164	-1000.0
Syndecan-1-mediated signaling events	1.0	67.0	34.0	-0.279	0.013	1000.0	-1000.0	-0.124	-1000.0
JNK signaling in the CD4+ TCR pathway	1.0	31.0	17.0	-0.121	0.013	1000.0	-1000.0	-0.113	-1000.0
Thromboxane A2 receptor signaling	1.0	105.0	105.0	-0.513	0.037	1000.0	-1000.0	-0.132	-1000.0
Syndecan-2-mediated signaling events	1.0	125.0	69.0	-0.291	0.044	1000.0	-1000.0	-0.105	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	85.0	61.0	-0.328	0.038	1000.0	-1000.0	-0.118	-1000.0
BMP receptor signaling	1.0	155.0	81.0	-0.407	0.054	1000.0	-1000.0	-0.173	-1000.0
mTOR signaling pathway	1.0	92.0	53.0	-0.513	0.037	1000.0	-1000.0	-0.102	-1000.0
Ceramide signaling pathway	1.0	89.0	76.0	-0.513	0.142	1000.0	-1000.0	-0.121	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	45.0	37.0	-0.204	0.02	1000.0	-1000.0	-0.138	-1000.0
HIF-2-alpha transcription factor network	1.0	60.0	43.0	-0.079	0.034	1000.0	-1000.0	-0.157	-1000.0
S1P1 pathway	1.0	37.0	36.0	-0.162	0.016	1000.0	-1000.0	-0.105	-1000.0
TCGA08_p53	1.0	12.0	7.0	-0.144	0.074	1000.0	-1000.0	-0.022	-1000.0
Retinoic acid receptors-mediated signaling	1.0	82.0	58.0	-0.31	0.016	1000.0	-1000.0	-0.131	-1000.0
Integrins in angiogenesis	1.0	113.0	84.0	-0.3	0.031	1000.0	-1000.0	-0.189	-1000.0
Canonical Wnt signaling pathway	1.0	69.0	51.0	-0.328	0.089	1000.0	-1000.0	-0.118	-1000.0
Nongenotropic Androgen signaling	1.0	73.0	52.0	-0.074	0.015	1000.0	-1000.0	-0.102	-1000.0
LPA receptor mediated events	1.0	182.0	102.0	-0.276	0.03	1000.0	-1000.0	-0.152	-1000.0
Regulation of Telomerase	1.0	127.0	102.0	-0.513	0.052	1000.0	-1000.0	-0.175	-1000.0
Plasma membrane estrogen receptor signaling	1.0	147.0	86.0	-0.3	0.028	1000.0	-1000.0	-0.136	-1000.0
Rapid glucocorticoid signaling	1.0	27.0	20.0	-0.282	0.013	1000.0	-1000.0	-0.067	-1000.0
Signaling events mediated by PRL	1.0	38.0	34.0	-0.098	0.013	1000.0	-1000.0	-0.08	-1000.0
FOXM1 transcription factor network	1.0	57.0	51.0	-0.195	0.1	1000.0	-1000.0	-0.249	-1000.0
p38 MAPK signaling pathway	1.0	50.0	44.0	-0.311	0.018	1000.0	-1000.0	-0.106	-1000.0
Regulation of Androgen receptor activity	1.0	99.0	70.0	-0.386	0.069	1000.0	-1000.0	-0.118	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	18.0	17.0	-0.036	0.013	1000.0	-1000.0	-0.081	-1000.0
LPA4-mediated signaling events	0.0	10.0	12.0	-0.04	0.022	1000.0	-1000.0	-0.056	-1000.0
ErbB2/ErbB3 signaling events	0.0	47.0	65.0	-0.13	0.028	1000.0	-1000.0	-0.121	-1000.0
Regulation of nuclear SMAD2/3 signaling	0.0	116.0	136.0	-0.256	0.122	1000.0	-1000.0	-0.136	-1000.0
Coregulation of Androgen receptor activity	0.0	66.0	76.0	-0.18	0.034	1000.0	-1000.0	-0.087	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	0.0	23.0	0.0	0.05	1000.0	-1000.0	-0.135	-1000.0
Canonical NF-kappaB pathway	0.0	7.0	39.0	-0.053	0.089	1000.0	-1000.0	-0.135	-1000.0
Signaling events mediated by HDAC Class II	0.0	22.0	75.0	-0.106	0.035	1000.0	-1000.0	-0.12	-1000.0
BARD1 signaling events	0.0	40.0	57.0	-0.039	0.056	1000.0	-1000.0	-0.125	-1000.0
Sphingosine 1-phosphate (S1P) pathway	0.0	24.0	28.0	-0.074	0.013	1000.0	-1000.0	-0.1	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.013	0.025	1000.0	-1000.0	-0.041	-1000.0
Circadian rhythm pathway	0.0	10.0	22.0	-0.016	0.038	1000.0	-1000.0	-0.101	-1000.0
Osteopontin-mediated events	0.0	20.0	38.0	-0.105	0.015	1000.0	-1000.0	-0.196	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.0	0.013	1000.0	-1000.0	-0.061	-1000.0
Cellular roles of Anthrax toxin	0.0	25.0	39.0	-0.053	0.019	1000.0	-1000.0	-0.055	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	0.0	42.0	85.0	-0.085	0.048	1000.0	-1000.0	-0.129	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	7.0	65.0	-0.073	0.079	1000.0	-1000.0	-0.111	-1000.0
Aurora A signaling	0.0	14.0	60.0	-0.081	0.031	1000.0	-1000.0	-0.116	-1000.0
Arf6 downstream pathway	0.0	6.0	43.0	-0.016	0.037	1000.0	-1000.0	-0.073	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.0	0.013	1000.0	-1000.0	-0.073	-1000.0
EPO signaling pathway	0.0	32.0	55.0	-0.155	0.015	1000.0	-1000.0	-0.171	-1000.0
Fc-epsilon receptor I signaling in mast cells	0.0	87.0	97.0	-0.093	0.046	1000.0	-1000.0	-0.154	-1000.0
PLK1 signaling events	0.0	16.0	85.0	-0.027	0.029	1000.0	-1000.0	-0.089	-1000.0
Insulin-mediated glucose transport	0.0	9.0	32.0	-0.037	0.037	1000.0	-1000.0	-0.108	-1000.0
PDGFR-alpha signaling pathway	0.0	10.0	44.0	-0.126	0.028	1000.0	-1000.0	-0.118	-1000.0
IFN-gamma pathway	0.0	43.0	68.0	-0.311	0.03	1000.0	-1000.0	-0.177	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	14.0	68.0	-0.048	0.055	1000.0	-1000.0	-0.108	-1000.0
Nectin adhesion pathway	0.0	4.0	63.0	-0.029	0.064	1000.0	-1000.0	-0.139	-1000.0
Signaling events mediated by HDAC Class III	0.0	31.0	40.0	-0.126	0.025	1000.0	-1000.0	-0.07	-1000.0
TRAIL signaling pathway	0.0	8.0	48.0	-0.019	0.058	1000.0	-1000.0	-0.111	-1000.0
IL1-mediated signaling events	0.0	48.0	62.0	-0.164	0.052	1000.0	-1000.0	-0.183	-1000.0
S1P5 pathway	0.0	13.0	17.0	-0.074	0.044	1000.0	-1000.0	-0.096	-1000.0
ceramide signaling pathway	0.0	7.0	49.0	-0.053	0.046	1000.0	-1000.0	-0.087	-1000.0
Ephrin B reverse signaling	0.0	16.0	48.0	-0.086	0.045	1000.0	-1000.0	-0.13	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	34.0	83.0	-0.272	0.063	1000.0	-1000.0	-0.138	-1000.0
Signaling events mediated by HDAC Class I	0.0	36.0	104.0	-0.108	0.052	1000.0	-1000.0	-0.133	-1000.0
FoxO family signaling	0.0	34.0	64.0	-0.384	0.135	1000.0	-1000.0	-0.124	-1000.0
FAS signaling pathway (CD95)	0.0	37.0	47.0	-0.292	0.062	1000.0	-1000.0	-0.104	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	5.0	15.0	-0.0	0.033	1000.0	-1000.0	-0.073	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	2.0	36.0	-0.029	0.025	1000.0	-1000.0	-0.116	-1000.0
Atypical NF-kappaB pathway	0.0	8.0	31.0	-0.036	0.039	1000.0	-1000.0	-0.119	-1000.0
IL2 signaling events mediated by PI3K	0.0	22.0	58.0	-0.072	0.065	1000.0	-1000.0	-0.146	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	17.0	45.0	-0.143	0.058	1000.0	-1000.0	-0.16	-1000.0
EPHB forward signaling	0.0	49.0	85.0	-0.158	0.054	1000.0	-1000.0	-0.168	-1000.0
Regulation of p38-alpha and p38-beta	0.0	46.0	54.0	-0.492	0.013	1000.0	-1000.0	-0.111	-1000.0
Glypican 2 network	0.0	3.0	4.0	-0.019	-1000.0	1000.0	-1000.0	-0.062	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	2.0	125.0	-0.016	0.098	1000.0	-1000.0	-0.186	-1000.0
TCGA08_rtk_signaling	0.0	1.0	26.0	-0.038	0.055	1000.0	-1000.0	-0.04	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	0.0	56.0	74.0	-0.513	0.074	1000.0	-1000.0	-0.157	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	1.0	76.0	-0.012	0.068	1000.0	-1000.0	-0.144	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.031	1000.0	-1000.0	-0.094	-1000.0
IL2 signaling events mediated by STAT5	0.0	8.0	22.0	-0.056	0.046	1000.0	-1000.0	-0.095	-1000.0
Class I PI3K signaling events	0.0	62.0	73.0	-0.492	0.049	1000.0	-1000.0	-0.121	-1000.0
Arf6 trafficking events	0.0	47.0	71.0	-0.254	0.046	1000.0	-1000.0	-0.127	-1000.0
VEGFR1 specific signals	0.0	0.0	56.0	0.0	0.075	1000.0	-1000.0	-0.142	-1000.0
S1P3 pathway	0.0	12.0	42.0	-0.072	0.038	1000.0	-1000.0	-0.103	-1000.0
Angiopoietin receptor Tie2-mediated signaling	0.0	83.0	88.0	-0.168	0.08	1000.0	-1000.0	-0.178	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	29.0	33.0	-0.185	0.037	1000.0	-1000.0	-0.112	-1000.0
PDGFR-beta signaling pathway	0.0	26.0	97.0	-0.29	0.059	1000.0	-1000.0	-0.175	-1000.0
E-cadherin signaling in keratinocytes	0.0	10.0	43.0	-0.033	0.053	1000.0	-1000.0	-0.131	-1000.0
S1P4 pathway	0.0	19.0	25.0	-0.074	0.013	1000.0	-1000.0	-0.094	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.0	0.013	1000.0	-1000.0	-0.074	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	0.0	40.0	78.0	-0.157	0.05	1000.0	-1000.0	-0.133	-1000.0
Arf1 pathway	0.0	1.0	54.0	-0.008	0.032	1000.0	-1000.0	-0.084	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.013	1000.0	-1000.0	-0.112	-1000.0
Aurora B signaling	0.0	18.0	67.0	-0.161	0.039	1000.0	-1000.0	-0.124	-1000.0
Total	155	11984	7203	-30.5985282256	-1993.30847309	131000	-131000	-16.5599267938	-131000