Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	11.0	511.0	46.0	-0.927	0.05	1000.0	-1000.0	-0.175	-1000.0
HIF-1-alpha transcription factor network	6.0	461.0	76.0	-0.607	0.032	1000.0	-1000.0	-0.237	-1000.0
EGFR-dependent Endothelin signaling events	6.0	131.0	21.0	-0.362	0.035	1000.0	-1000.0	-0.061	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	5.0	172.0	34.0	-0.213	0.025	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by the Hedgehog family	5.0	261.0	52.0	-0.182	0.123	1000.0	-1000.0	-0.073	-1000.0
IL4-mediated signaling events	5.0	455.0	91.0	-0.742	0.687	1000.0	-1000.0	-0.169	-1000.0
IL23-mediated signaling events	5.0	341.0	60.0	-0.551	0.025	1000.0	-1000.0	-0.133	-1000.0
Ephrin A  reverse signaling	4.0	34.0	7.0	-0.05	0.0	1000.0	-1000.0	-0.031	-1000.0
Wnt signaling	4.0	28.0	7.0	-0.235	0.025	1000.0	-1000.0	-0.044	-1000.0
IL6-mediated signaling events	4.0	303.0	75.0	-0.58	0.042	1000.0	-1000.0	-0.075	-1000.0
BCR signaling pathway	4.0	397.0	99.0	-0.317	0.03	1000.0	-1000.0	-0.096	-1000.0
Signaling events mediated by PTP1B	3.0	257.0	76.0	-0.363	0.065	1000.0	-1000.0	-0.067	-1000.0
p75(NTR)-mediated signaling	3.0	471.0	125.0	-0.256	0.064	1000.0	-1000.0	-0.11	-1000.0
Glypican 1 network	3.0	160.0	48.0	-0.377	0.046	1000.0	-1000.0	-0.05	-1000.0
amb2 Integrin signaling	3.0	264.0	82.0	-0.199	0.042	1000.0	-1000.0	-0.064	-1000.0
Glucocorticoid receptor regulatory network	3.0	438.0	114.0	-0.715	0.3	1000.0	-1000.0	-0.089	-1000.0
Reelin signaling pathway	3.0	209.0	56.0	-0.211	0.059	1000.0	-1000.0	-0.073	-1000.0
Signaling events regulated by Ret tyrosine kinase	3.0	263.0	82.0	-0.106	0.025	1000.0	-1000.0	-0.101	-1000.0
TCGA08_p53	3.0	27.0	7.0	-0.092	0.074	1000.0	-1000.0	-0.01	-1000.0
TCR signaling in naïve CD8+ T cells	3.0	329.0	93.0	-0.135	0.059	1000.0	-1000.0	-0.095	-1000.0
Calcium signaling in the CD4+ TCR pathway	3.0	104.0	31.0	-0.335	0.025	1000.0	-1000.0	-0.094	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	3.0	204.0	68.0	-0.427	0.129	1000.0	-1000.0	-0.143	-1000.0
TCGA08_retinoblastoma	3.0	30.0	8.0	-0.115	0.043	1000.0	-1000.0	-0.021	-1000.0
Visual signal transduction: Rods	3.0	184.0	52.0	-0.288	0.025	1000.0	-1000.0	-0.075	-1000.0
IL12-mediated signaling events	2.0	259.0	87.0	-0.246	0.028	1000.0	-1000.0	-0.145	-1000.0
ErbB4 signaling events	2.0	139.0	69.0	-0.274	0.12	1000.0	-1000.0	-0.084	-1000.0
Syndecan-1-mediated signaling events	2.0	73.0	34.0	-0.188	0.025	1000.0	-1000.0	-0.079	-1000.0
Visual signal transduction: Cones	2.0	96.0	38.0	-0.144	0.034	1000.0	-1000.0	-0.037	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	129.0	54.0	-0.211	0.035	1000.0	-1000.0	-0.101	-1000.0
Noncanonical Wnt signaling pathway	2.0	66.0	26.0	-0.235	0.025	1000.0	-1000.0	-0.076	-1000.0
Thromboxane A2 receptor signaling	2.0	217.0	105.0	-0.362	0.059	1000.0	-1000.0	-0.066	-1000.0
Arf6 signaling events	2.0	137.0	62.0	-0.362	0.038	1000.0	-1000.0	-0.05	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	2.0	155.0	52.0	-0.289	0.068	1000.0	-1000.0	-0.062	-1000.0
Endothelins	2.0	229.0	96.0	-0.229	0.069	1000.0	-1000.0	-0.093	-1000.0
Signaling mediated by p38-alpha and p38-beta	2.0	99.0	44.0	-0.155	0.025	1000.0	-1000.0	-0.052	-1000.0
Effects of Botulinum toxin	2.0	62.0	26.0	-0.125	0.025	1000.0	-1000.0	-0.044	-1000.0
IL27-mediated signaling events	2.0	122.0	51.0	-0.2	0.066	1000.0	-1000.0	-0.069	-1000.0
Syndecan-4-mediated signaling events	2.0	151.0	67.0	-0.186	0.036	1000.0	-1000.0	-0.079	-1000.0
IGF1 pathway	2.0	117.0	57.0	-0.192	0.044	1000.0	-1000.0	-0.097	-1000.0
Insulin Pathway	2.0	221.0	74.0	-0.349	0.062	1000.0	-1000.0	-0.091	-1000.0
Plasma membrane estrogen receptor signaling	2.0	176.0	86.0	-0.194	0.075	1000.0	-1000.0	-0.101	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	2.0	266.0	120.0	-0.283	0.13	1000.0	-1000.0	-0.075	-1000.0
Class IB PI3K non-lipid kinase events	2.0	6.0	3.0	-0.009	-1000.0	1000.0	-1000.0	-0.009	-1000.0
Caspase cascade in apoptosis	1.0	100.0	74.0	-0.086	0.053	1000.0	-1000.0	-0.051	-1000.0
JNK signaling in the CD4+ TCR pathway	1.0	30.0	17.0	-0.034	0.025	1000.0	-1000.0	-0.057	-1000.0
Syndecan-2-mediated signaling events	1.0	104.0	69.0	-0.186	0.066	1000.0	-1000.0	-0.039	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	91.0	85.0	-0.05	0.046	1000.0	-1000.0	-0.068	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	88.0	61.0	-0.227	0.065	1000.0	-1000.0	-0.071	-1000.0
BMP receptor signaling	1.0	134.0	81.0	-0.273	0.058	1000.0	-1000.0	-0.093	-1000.0
Fc-epsilon receptor I signaling in mast cells	1.0	102.0	97.0	-0.05	0.045	1000.0	-1000.0	-0.094	-1000.0
mTOR signaling pathway	1.0	104.0	53.0	-0.354	0.046	1000.0	-1000.0	-0.064	-1000.0
Ceramide signaling pathway	1.0	116.0	76.0	-0.362	0.111	1000.0	-1000.0	-0.069	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	42.0	37.0	-0.125	0.062	1000.0	-1000.0	-0.052	-1000.0
S1P5 pathway	1.0	17.0	17.0	-0.036	0.025	1000.0	-1000.0	-0.041	-1000.0
HIF-2-alpha transcription factor network	1.0	50.0	43.0	-0.066	0.047	1000.0	-1000.0	-0.112	-1000.0
S1P1 pathway	1.0	46.0	36.0	-0.13	0.025	1000.0	-1000.0	-0.075	-1000.0
FAS signaling pathway (CD95)	1.0	87.0	47.0	-0.216	0.04	1000.0	-1000.0	-0.06	-1000.0
Retinoic acid receptors-mediated signaling	1.0	79.0	58.0	-0.219	0.051	1000.0	-1000.0	-0.065	-1000.0
Syndecan-3-mediated signaling events	1.0	58.0	35.0	-0.122	0.064	1000.0	-1000.0	-0.064	-1000.0
Integrins in angiogenesis	1.0	106.0	84.0	-0.194	0.063	1000.0	-1000.0	-0.1	-1000.0
Canonical Wnt signaling pathway	1.0	78.0	51.0	-0.227	0.134	1000.0	-1000.0	-0.078	-1000.0
Regulation of p38-alpha and p38-beta	1.0	84.0	54.0	-0.333	0.057	1000.0	-1000.0	-0.062	-1000.0
Nongenotropic Androgen signaling	1.0	73.0	52.0	-0.061	0.044	1000.0	-1000.0	-0.074	-1000.0
LPA receptor mediated events	1.0	201.0	102.0	-0.183	0.056	1000.0	-1000.0	-0.086	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	1.0	78.0	74.0	-0.362	0.071	1000.0	-1000.0	-0.106	-1000.0
Regulation of Telomerase	1.0	113.0	102.0	-0.361	0.056	1000.0	-1000.0	-0.097	-1000.0
Rapid glucocorticoid signaling	1.0	27.0	20.0	-0.192	0.032	1000.0	-1000.0	-0.013	-1000.0
p38 MAPK signaling pathway	1.0	49.0	44.0	-0.216	0.043	1000.0	-1000.0	-0.06	-1000.0
Regulation of Androgen receptor activity	1.0	100.0	70.0	-0.255	0.037	1000.0	-1000.0	-0.076	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	21.0	17.0	-0.031	0.04	1000.0	-1000.0	-0.056	-1000.0
LPA4-mediated signaling events	0.0	10.0	12.0	-0.031	0.016	1000.0	-1000.0	-0.038	-1000.0
ErbB2/ErbB3 signaling events	0.0	54.0	65.0	-0.085	0.034	1000.0	-1000.0	-0.08	-1000.0
Regulation of nuclear SMAD2/3 signaling	0.0	109.0	136.0	-0.128	0.109	1000.0	-1000.0	-0.071	-1000.0
Coregulation of Androgen receptor activity	0.0	58.0	76.0	-0.115	0.052	1000.0	-1000.0	-0.038	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	1.0	23.0	0.01	0.047	1000.0	-1000.0	-0.05	-1000.0
Canonical NF-kappaB pathway	0.0	4.0	39.0	-0.005	0.082	1000.0	-1000.0	-0.075	-1000.0
Signaling events mediated by HDAC Class II	0.0	21.0	75.0	-0.065	0.07	1000.0	-1000.0	-0.048	-1000.0
BARD1 signaling events	0.0	42.0	57.0	-0.025	0.044	1000.0	-1000.0	-0.081	-1000.0
Sphingosine 1-phosphate (S1P) pathway	0.0	20.0	28.0	-0.036	0.042	1000.0	-1000.0	-0.047	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.02	0.025	1000.0	-1000.0	-0.025	-1000.0
Circadian rhythm pathway	0.0	8.0	22.0	-0.01	0.056	1000.0	-1000.0	-0.053	-1000.0
Osteopontin-mediated events	0.0	22.0	38.0	-0.114	0.037	1000.0	-1000.0	-0.075	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	0.0	5.0	0.024	0.037	1000.0	-1000.0	-0.011	-1000.0
Cellular roles of Anthrax toxin	0.0	28.0	39.0	-0.017	0.025	1000.0	-1000.0	-0.033	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	8.0	65.0	-0.035	0.064	1000.0	-1000.0	-0.074	-1000.0
Aurora A signaling	0.0	10.0	60.0	-0.039	0.06	1000.0	-1000.0	-0.04	-1000.0
Arf6 downstream pathway	0.0	6.0	43.0	-0.046	0.048	1000.0	-1000.0	-0.048	-1000.0
Aurora C signaling	0.0	0.0	7.0	-0.0	0.04	1000.0	-1000.0	-0.025	-1000.0
EPO signaling pathway	0.0	51.0	55.0	-0.093	0.025	1000.0	-1000.0	-0.078	-1000.0
PLK1 signaling events	0.0	43.0	85.0	-0.02	0.057	1000.0	-1000.0	-0.046	-1000.0
Insulin-mediated glucose transport	0.0	8.0	32.0	-0.009	0.044	1000.0	-1000.0	-0.048	-1000.0
PDGFR-alpha signaling pathway	0.0	10.0	44.0	-0.097	0.054	1000.0	-1000.0	-0.063	-1000.0
IFN-gamma pathway	0.0	56.0	68.0	-0.216	0.033	1000.0	-1000.0	-0.093	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	5.0	68.0	-0.052	0.064	1000.0	-1000.0	-0.062	-1000.0
Nectin adhesion pathway	0.0	7.0	63.0	-0.0	0.067	1000.0	-1000.0	-0.073	-1000.0
Signaling events mediated by HDAC Class III	0.0	31.0	40.0	-0.079	0.043	1000.0	-1000.0	-0.03	-1000.0
TRAIL signaling pathway	0.0	7.0	48.0	-0.0	0.062	1000.0	-1000.0	-0.063	-1000.0
IL1-mediated signaling events	0.0	45.0	62.0	-0.102	0.047	1000.0	-1000.0	-0.094	-1000.0
ceramide signaling pathway	0.0	20.0	49.0	-0.005	0.037	1000.0	-1000.0	-0.066	-1000.0
Ephrin B reverse signaling	0.0	12.0	48.0	-0.051	0.036	1000.0	-1000.0	-0.057	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	40.0	83.0	-0.18	0.046	1000.0	-1000.0	-0.075	-1000.0
Signaling events mediated by HDAC Class I	0.0	32.0	104.0	-0.065	0.059	1000.0	-1000.0	-0.067	-1000.0
FoxO family signaling	0.0	43.0	64.0	-0.32	0.1	1000.0	-1000.0	-0.09	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	5.0	15.0	-0.006	0.025	1000.0	-1000.0	-0.044	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	2.0	36.0	-0.057	0.059	1000.0	-1000.0	-0.06	-1000.0
Atypical NF-kappaB pathway	0.0	9.0	31.0	-0.012	0.038	1000.0	-1000.0	-0.063	-1000.0
IL2 signaling events mediated by PI3K	0.0	33.0	58.0	-0.034	0.079	1000.0	-1000.0	-0.073	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	22.0	45.0	-0.082	0.066	1000.0	-1000.0	-0.091	-1000.0
EPHB forward signaling	0.0	50.0	85.0	-0.096	0.104	1000.0	-1000.0	-0.104	-1000.0
Glypican 2 network	0.0	3.0	4.0	0.006	0.022	1000.0	-1000.0	-0.007	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	12.0	125.0	-0.0	0.075	1000.0	-1000.0	-0.099	-1000.0
TCGA08_rtk_signaling	0.0	2.0	26.0	-0.04	0.067	1000.0	-1000.0	-0.027	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	11.0	76.0	-0.005	0.068	1000.0	-1000.0	-0.098	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.001	0.054	1000.0	-1000.0	-0.065	-1000.0
IL2 signaling events mediated by STAT5	0.0	12.0	22.0	-0.041	0.042	1000.0	-1000.0	-0.064	-1000.0
Class I PI3K signaling events	0.0	63.0	73.0	-0.333	0.058	1000.0	-1000.0	-0.069	-1000.0
Arf6 trafficking events	0.0	33.0	71.0	-0.211	0.053	1000.0	-1000.0	-0.058	-1000.0
VEGFR1 specific signals	0.0	0.0	56.0	-0.0	0.068	1000.0	-1000.0	-0.079	-1000.0
S1P3 pathway	0.0	24.0	42.0	-0.035	0.045	1000.0	-1000.0	-0.057	-1000.0
Angiopoietin receptor Tie2-mediated signaling	0.0	85.0	88.0	-0.108	0.088	1000.0	-1000.0	-0.093	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	21.0	33.0	-0.118	0.056	1000.0	-1000.0	-0.047	-1000.0
PDGFR-beta signaling pathway	0.0	32.0	97.0	-0.217	0.063	1000.0	-1000.0	-0.089	-1000.0
Signaling events mediated by PRL	0.0	20.0	34.0	-0.046	0.037	1000.0	-1000.0	-0.058	-1000.0
E-cadherin signaling in keratinocytes	0.0	8.0	43.0	-0.035	0.053	1000.0	-1000.0	-0.074	-1000.0
FOXM1 transcription factor network	0.0	50.0	51.0	-0.121	0.067	1000.0	-1000.0	-0.184	-1000.0
S1P4 pathway	0.0	19.0	25.0	-0.036	0.034	1000.0	-1000.0	-0.052	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.025	0.049	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	0.0	26.0	78.0	-0.094	0.053	1000.0	-1000.0	-0.101	-1000.0
Arf1 pathway	0.0	3.0	54.0	-0.0	0.042	1000.0	-1000.0	-0.036	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.064	1000.0	-1000.0	-0.027	-1000.0
Aurora B signaling	0.0	26.0	67.0	-0.154	0.073	1000.0	-1000.0	-0.06	-1000.0
Total	163	12314	7203	-21.4045064366	-992.280613917	131000	-131000	-9.24500811799	-131000