Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.008 0.137 -9999.0 0.0 -0.541 7.0 7.0 IHH -0.046 0.188 -9999.0 0.0 -0.58 19.0 19.0 SHH Np/Cholesterol/GAS1 -0.116 0.192 -9999.0 0.0 -0.395 52.0 52.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.116 0.191 0.392 52.0 -9999.0 0.0 52.0 SMO/beta Arrestin2 0.004 0.104 -9999.0 0.0 -0.457 2.0 2.0 SMO -0.002 0.109 -9999.0 0.0 -0.436 4.0 4.0 AKT1 0.019 0.055 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.008 0.047 -9999.0 0.0 -0.617 1.0 1.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.002 0.108 -9999.0 0.0 -0.43 4.0 4.0 STIL -0.093 0.208 -9999.0 0.0 -0.587 15.0 15.0 DHH N/PTCH2 -0.008 0.058 -9999.0 0.0 -0.447 3.0 3.0 DHH N/PTCH1 0.004 0.106 -9999.0 0.0 -0.407 1.0 1.0 PIK3CA 0.009 0.046 -9999.0 0.0 -0.603 1.0 1.0 DHH 0.001 0.081 -9999.0 0.0 -0.613 3.0 3.0 PTHLH -0.0 0.195 -9999.0 0.0 -0.869 7.0 7.0 determination of left/right symmetry -0.002 0.108 -9999.0 0.0 -0.43 4.0 4.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.0 0.193 -9999.0 0.0 -0.858 7.0 7.0 IHH N/Hhip -0.045 0.164 -9999.0 0.0 -0.409 28.0 28.0 DHH N/Hhip -0.033 0.117 -9999.0 0.0 -0.449 13.0 13.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.002 0.108 -9999.0 0.0 -0.43 4.0 4.0 pancreas development -0.024 0.145 -9999.0 0.0 -0.615 10.0 10.0 HHAT -0.002 0.094 -9999.0 0.0 -0.617 4.0 4.0 PI3K -0.002 0.033 -9999.0 0.0 -0.439 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.042 0.176 -9999.0 0.0 -0.617 15.0 15.0 somite specification -0.002 0.108 -9999.0 0.0 -0.43 4.0 4.0 SHH Np/Cholesterol/PTCH1 -0.068 0.181 -9999.0 0.0 -0.543 10.0 10.0 SHH Np/Cholesterol/PTCH2 -0.087 0.158 -9999.0 0.0 -0.358 43.0 43.0 SHH Np/Cholesterol/Megalin -0.134 0.2 -9999.0 0.0 -0.388 61.0 61.0 SHH -0.098 0.213 -9999.0 0.0 -0.466 43.0 43.0 catabolic process 0.004 0.11 -9999.0 0.0 -0.462 1.0 1.0 SMO/Vitamin D3 -0.056 0.179 -9999.0 0.0 -0.533 10.0 10.0 SHH Np/Cholesterol/Hhip -0.106 0.193 -9999.0 0.0 -0.409 46.0 46.0 LRP2 -0.074 0.216 -9999.0 0.0 -0.616 24.0 24.0 receptor-mediated endocytosis -0.121 0.173 -9999.0 0.0 -0.57 13.0 13.0 SHH Np/Cholesterol/BOC -0.089 0.163 -9999.0 0.0 -0.366 43.0 43.0 SHH Np/Cholesterol/CDO -0.097 0.167 -9999.0 0.0 -0.363 47.0 47.0 mesenchymal cell differentiation 0.106 0.191 0.406 46.0 -9999.0 0.0 46.0 mol:Vitamin D3 -0.066 0.182 -9999.0 0.0 -0.526 11.0 11.0 IHH N/PTCH2 -0.017 0.115 -9999.0 0.0 -0.345 19.0 19.0 CDON -0.006 0.103 -9999.0 0.0 -0.606 5.0 5.0 IHH N/PTCH1 0.004 0.111 -9999.0 0.0 -0.468 1.0 1.0 Megalin/LRPAP1 -0.061 0.154 -9999.0 0.0 -0.45 24.0 24.0 PTCH2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.089 0.161 -9999.0 0.0 -0.366 43.0 43.0 PTCH1 0.004 0.11 -9999.0 0.0 -0.463 1.0 1.0 HHIP -0.024 0.145 -9999.0 0.0 -0.616 10.0 10.0