Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.038 0.072 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.009 0.114 -9999.0 0.0 -0.617 6.0 6.0 EPHA2 -0.052 0.19 -9999.0 0.0 -0.616 18.0 18.0 MYO6 -0.028 0.129 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.254 0.23 -9999.0 0.0 -0.463 96.0 96.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.035 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.02 0.069 -9999.0 0.0 -9999.0 0.0 0.0 EGF -0.097 0.235 -9999.0 0.0 -0.605 31.0 31.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.013 0.077 -9999.0 0.0 -0.463 5.0 5.0 cortical microtubule organization 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.034 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.012 0.001 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.025 0.073 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.035 0.102 -9999.0 0.0 -0.339 16.0 16.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.044 0.022 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.036 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.031 0.093 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.058 0.118 -9999.0 0.0 -0.586 1.0 1.0 RhoA/GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.017 0.118 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.005 0.065 -9999.0 0.0 -0.602 2.0 2.0 GIT1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.005 0.065 -9999.0 0.0 -0.603 2.0 2.0 IGF1 -0.055 0.194 -9999.0 0.0 -0.612 19.0 19.0 DIAPH1 -0.001 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.024 0.072 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.018 0.121 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.038 0.035 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.029 0.086 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.02 0.07 -9999.0 0.0 -9999.0 0.0 0.0 HGF/MET -0.037 0.1 -9999.0 0.0 -0.595 1.0 1.0 HGF -0.03 0.156 -9999.0 0.0 -0.606 12.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.057 0.058 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.042 0.0 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 0.03 0.044 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.036 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.036 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.036 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.032 0.081 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.049 0.055 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.034 0.096 -9999.0 0.0 -0.577 1.0 1.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.027 0.152 -9999.0 0.0 -0.617 11.0 11.0 PLEKHA7 0.036 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.034 0.102 -9999.0 0.0 -0.337 16.0 16.0 establishment of epithelial cell apical/basal polarity 0.058 0.0 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion -0.017 0.118 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0