Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.01 0.112 -9999.0 0.0 -0.527 6.0 6.0 IHH 0.004 0.097 0.196 1.0 -0.257 17.0 18.0 SHH Np/Cholesterol/GAS1 -0.04 0.115 -9999.0 0.0 -0.265 32.0 32.0 LRPAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.04 0.114 0.263 32.0 -9999.0 0.0 32.0 SMO/beta Arrestin2 0.021 0.086 -9999.0 0.0 -0.352 4.0 4.0 SMO 0.004 0.08 -9999.0 0.0 -0.334 7.0 7.0 AKT1 0.012 0.075 -9999.0 0.0 -0.372 2.0 2.0 ARRB2 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.023 0.037 -9999.0 0.0 -0.456 1.0 1.0 ADRBK1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.004 0.08 -9999.0 0.0 -0.33 7.0 7.0 STIL -0.026 0.122 0.265 2.0 -0.367 7.0 9.0 DHH N/PTCH2 0.034 0.042 -9999.0 0.0 -0.327 2.0 2.0 DHH N/PTCH1 0.019 0.076 -9999.0 0.0 -0.256 10.0 10.0 PIK3CA 0.023 0.021 -9999.0 0.0 -0.232 1.0 1.0 DHH 0.02 0.055 -9999.0 0.0 -0.381 3.0 3.0 PTHLH -0.003 0.169 -9999.0 0.0 -0.846 6.0 6.0 determination of left/right symmetry 0.004 0.08 -9999.0 0.0 -0.33 7.0 7.0 PIK3R1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.002 0.167 -9999.0 0.0 -0.836 6.0 6.0 IHH N/Hhip 0.005 0.105 -9999.0 0.0 -0.349 11.0 11.0 DHH N/Hhip 0.016 0.087 -9999.0 0.0 -0.299 12.0 12.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.004 0.08 -9999.0 0.0 -0.33 7.0 7.0 pancreas development 0.003 0.102 -9999.0 0.0 -0.431 9.0 9.0 HHAT 0.02 0.052 -9999.0 0.0 -0.456 2.0 2.0 PI3K 0.033 0.021 -9999.0 0.0 -0.156 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.007 0.122 -9999.0 0.0 -0.456 12.0 12.0 somite specification 0.004 0.08 -9999.0 0.0 -0.33 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.026 0.106 -9999.0 0.0 -0.322 8.0 8.0 SHH Np/Cholesterol/PTCH2 -0.025 0.098 -9999.0 0.0 -0.253 24.0 24.0 SHH Np/Cholesterol/Megalin -0.059 0.131 -9999.0 0.0 -0.276 41.0 41.0 SHH -0.047 0.123 0.236 1.0 -0.269 37.0 38.0 catabolic process 0.011 0.072 -9999.0 0.0 -0.292 8.0 8.0 SMO/Vitamin D3 -0.013 0.118 0.309 3.0 -0.347 8.0 11.0 SHH Np/Cholesterol/Hhip -0.034 0.12 -9999.0 0.0 -0.298 25.0 25.0 LRP2 -0.036 0.158 -9999.0 0.0 -0.437 23.0 23.0 receptor-mediated endocytosis -0.047 0.134 -9999.0 0.0 -0.452 8.0 8.0 SHH Np/Cholesterol/BOC -0.025 0.098 -9999.0 0.0 -0.256 23.0 23.0 SHH Np/Cholesterol/CDO -0.028 0.098 -9999.0 0.0 -0.252 24.0 24.0 mesenchymal cell differentiation 0.034 0.119 0.296 25.0 -9999.0 0.0 25.0 mol:Vitamin D3 -0.013 0.122 0.383 1.0 -0.322 8.0 9.0 IHH N/PTCH2 0.024 0.062 -9999.0 0.0 -0.268 3.0 3.0 CDON 0.019 0.049 -9999.0 0.0 -0.288 4.0 4.0 IHH N/PTCH1 0.029 0.075 -9999.0 0.0 -0.294 8.0 8.0 Megalin/LRPAP1 -0.009 0.119 -9999.0 0.0 -0.311 23.0 23.0 PTCH2 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.032 0.094 -9999.0 0.0 -0.251 24.0 24.0 PTCH1 0.011 0.072 -9999.0 0.0 -0.293 8.0 8.0 HHIP 0.003 0.102 -9999.0 0.0 -0.431 9.0 9.0