Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.091 0.271 -9999.0 0.0 -0.623 8.0 8.0 IHH -0.033 0.165 -9999.0 0.0 -0.812 2.0 2.0 SHH Np/Cholesterol/GAS1 -0.143 0.192 -9999.0 0.0 -0.444 12.0 12.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.142 0.19 0.441 12.0 -9999.0 0.0 12.0 SMO/beta Arrestin2 -0.029 0.173 -9999.0 0.0 -0.782 1.0 1.0 SMO -0.036 0.182 -9999.0 0.0 -0.637 2.0 2.0 AKT1 0.005 0.084 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.111 0.253 -9999.0 0.0 -0.614 10.0 10.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.036 0.179 -9999.0 0.0 -0.625 2.0 2.0 STIL -0.031 0.176 -9999.0 0.0 -0.909 1.0 1.0 DHH N/PTCH2 -0.096 0.198 -9999.0 0.0 -0.488 10.0 10.0 DHH N/PTCH1 -0.082 0.192 -9999.0 0.0 -0.467 6.0 6.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.059 0.214 -9999.0 0.0 -0.702 5.0 5.0 PTHLH -0.153 0.406 -9999.0 0.0 -1.035 8.0 8.0 determination of left/right symmetry -0.036 0.179 -9999.0 0.0 -0.625 2.0 2.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.151 0.4 -9999.0 0.0 -1.018 8.0 8.0 IHH N/Hhip -0.088 0.246 -9999.0 0.0 -0.633 8.0 8.0 DHH N/Hhip -0.123 0.246 -9999.0 0.0 -0.57 11.0 11.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.036 0.179 -9999.0 0.0 -0.625 2.0 2.0 pancreas development -0.088 0.251 -9999.0 0.0 -0.713 7.0 7.0 HHAT 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.21 0.321 -9999.0 0.0 -0.655 17.0 17.0 somite specification -0.036 0.179 -9999.0 0.0 -0.625 2.0 2.0 SHH Np/Cholesterol/PTCH1 -0.041 0.186 -9999.0 0.0 -0.974 1.0 1.0 SHH Np/Cholesterol/PTCH2 -0.051 0.132 -9999.0 0.0 -0.444 4.0 4.0 SHH Np/Cholesterol/Megalin -0.05 0.138 -9999.0 0.0 -0.579 2.0 2.0 SHH -0.001 0.114 -9999.0 0.0 -0.564 2.0 2.0 catabolic process -0.049 0.181 -9999.0 0.0 -0.536 3.0 3.0 SMO/Vitamin D3 -0.036 0.192 -9999.0 0.0 -0.989 1.0 1.0 SHH Np/Cholesterol/Hhip -0.074 0.202 -9999.0 0.0 -0.585 6.0 6.0 LRP2 -0.055 0.172 -9999.0 0.0 -0.527 6.0 6.0 receptor-mediated endocytosis -0.079 0.187 -9999.0 0.0 -1.073 1.0 1.0 SHH Np/Cholesterol/BOC -0.085 0.159 -9999.0 0.0 -0.444 6.0 6.0 SHH Np/Cholesterol/CDO -0.017 0.086 -9999.0 0.0 -0.444 2.0 2.0 mesenchymal cell differentiation 0.074 0.2 0.579 6.0 -9999.0 0.0 6.0 mol:Vitamin D3 -0.039 0.188 -9999.0 0.0 -0.979 1.0 1.0 IHH N/PTCH2 -0.058 0.185 -9999.0 0.0 -0.512 7.0 7.0 CDON 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.05 0.182 -9999.0 0.0 -0.543 3.0 3.0 Megalin/LRPAP1 -0.044 0.12 -9999.0 0.0 -0.374 6.0 6.0 PTCH2 -0.049 0.189 -9999.0 0.0 -0.614 5.0 5.0 SHH Np/Cholesterol -0.018 0.088 -9999.0 0.0 -0.451 2.0 2.0 PTCH1 -0.049 0.181 -9999.0 0.0 -0.539 3.0 3.0 HHIP -0.088 0.252 -9999.0 0.0 -0.714 7.0 7.0