Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
IL4-mediated signaling events	12.0	1181.0	91.0	-1.104	0.946	1000.0	-1000.0	-0.175	-1000.0
IL23-mediated signaling events	10.0	648.0	60.0	-0.704	0.012	1000.0	-1000.0	-0.184	-1000.0
amb2 Integrin signaling	7.0	590.0	82.0	-0.281	0.012	1000.0	-1000.0	-0.094	-1000.0
Signaling mediated by p38-alpha and p38-beta	7.0	331.0	44.0	-0.271	0.012	1000.0	-1000.0	-0.061	-1000.0
Wnt signaling	7.0	55.0	7.0	-0.213	-0.003	1000.0	-1000.0	-0.044	-1000.0
Ephrin A  reverse signaling	6.0	46.0	7.0	-0.119	0.01	1000.0	-1000.0	-0.037	-1000.0
Noncanonical Wnt signaling pathway	6.0	171.0	26.0	-0.235	0.012	1000.0	-1000.0	-0.095	-1000.0
FOXA2 and FOXA3 transcription factor networks	6.0	288.0	46.0	-0.59	0.021	1000.0	-1000.0	-0.12	-1000.0
Syndecan-4-mediated signaling events	6.0	466.0	67.0	-0.3	0.045	1000.0	-1000.0	-0.116	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	5.0	174.0	34.0	-0.134	0.012	1000.0	-1000.0	-0.072	-1000.0
Glypican 1 network	5.0	260.0	48.0	-0.391	0.023	1000.0	-1000.0	-0.055	-1000.0
Reelin signaling pathway	5.0	313.0	56.0	-0.259	0.012	1000.0	-1000.0	-0.088	-1000.0
Endothelins	5.0	511.0	96.0	-0.243	0.013	1000.0	-1000.0	-0.092	-1000.0
TCGA08_p53	5.0	38.0	7.0	-0.07	0.027	1000.0	-1000.0	-0.016	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	5.0	368.0	68.0	-0.447	0.162	1000.0	-1000.0	-0.145	-1000.0
BCR signaling pathway	5.0	551.0	99.0	-0.238	0.012	1000.0	-1000.0	-0.102	-1000.0
EGFR-dependent Endothelin signaling events	5.0	111.0	21.0	-0.259	0.012	1000.0	-1000.0	-0.081	-1000.0
Syndecan-1-mediated signaling events	4.0	149.0	34.0	-0.221	0.012	1000.0	-1000.0	-0.071	-1000.0
Signaling events mediated by the Hedgehog family	4.0	210.0	52.0	-0.21	0.142	1000.0	-1000.0	-0.086	-1000.0
p75(NTR)-mediated signaling	4.0	507.0	125.0	-0.246	0.012	1000.0	-1000.0	-0.116	-1000.0
Fc-epsilon receptor I signaling in mast cells	4.0	425.0	97.0	-0.288	0.041	1000.0	-1000.0	-0.093	-1000.0
Glucocorticoid receptor regulatory network	4.0	475.0	114.0	-0.432	0.294	1000.0	-1000.0	-0.082	-1000.0
TCR signaling in naïve CD8+ T cells	4.0	413.0	93.0	-0.238	0.015	1000.0	-1000.0	-0.09	-1000.0
Calcium signaling in the CD4+ TCR pathway	4.0	144.0	31.0	-0.313	0.012	1000.0	-1000.0	-0.1	-1000.0
LPA receptor mediated events	4.0	409.0	102.0	-0.218	0.015	1000.0	-1000.0	-0.1	-1000.0
IL12-mediated signaling events	3.0	338.0	87.0	-0.287	0.035	1000.0	-1000.0	-0.153	-1000.0
Visual signal transduction: Cones	3.0	142.0	38.0	-0.139	0.012	1000.0	-1000.0	-0.067	-1000.0
Osteopontin-mediated events	3.0	135.0	38.0	-0.252	0.012	1000.0	-1000.0	-0.119	-1000.0
Thromboxane A2 receptor signaling	3.0	397.0	105.0	-0.259	0.054	1000.0	-1000.0	-0.08	-1000.0
HIF-1-alpha transcription factor network	3.0	298.0	76.0	-0.441	0.02	1000.0	-1000.0	-0.202	-1000.0
Syndecan-2-mediated signaling events	3.0	272.0	69.0	-0.214	0.025	1000.0	-1000.0	-0.065	-1000.0
Presenilin action in Notch and Wnt signaling	3.0	195.0	61.0	-0.355	0.092	1000.0	-1000.0	-0.075	-1000.0
BMP receptor signaling	3.0	284.0	81.0	-0.236	0.035	1000.0	-1000.0	-0.115	-1000.0
PDGFR-alpha signaling pathway	3.0	134.0	44.0	-0.101	0.023	1000.0	-1000.0	-0.066	-1000.0
Signaling events regulated by Ret tyrosine kinase	3.0	325.0	82.0	-0.219	0.012	1000.0	-1000.0	-0.093	-1000.0
Ephrin B reverse signaling	3.0	179.0	48.0	-0.13	0.068	1000.0	-1000.0	-0.079	-1000.0
Canonical Wnt signaling pathway	3.0	162.0	51.0	-0.355	0.139	1000.0	-1000.0	-0.077	-1000.0
Glypican 2 network	3.0	12.0	4.0	-0.044	-0.003	1000.0	-1000.0	-0.043	-1000.0
Visual signal transduction: Rods	3.0	158.0	52.0	-0.214	0.012	1000.0	-1000.0	-0.087	-1000.0
LPA4-mediated signaling events	2.0	26.0	12.0	-0.081	0.019	1000.0	-1000.0	-0.027	-1000.0
Caspase cascade in apoptosis	2.0	211.0	74.0	-0.116	0.061	1000.0	-1000.0	-0.063	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	120.0	54.0	-0.212	0.025	1000.0	-1000.0	-0.108	-1000.0
Cellular roles of Anthrax toxin	2.0	116.0	39.0	-0.079	0.012	1000.0	-1000.0	-0.032	-1000.0
Arf6 signaling events	2.0	154.0	62.0	-0.259	0.019	1000.0	-1000.0	-0.083	-1000.0
Signaling events mediated by PTP1B	2.0	204.0	76.0	-0.261	0.066	1000.0	-1000.0	-0.093	-1000.0
IL1-mediated signaling events	2.0	178.0	62.0	-0.189	0.059	1000.0	-1000.0	-0.107	-1000.0
Integrins in angiogenesis	2.0	241.0	84.0	-0.257	0.012	1000.0	-1000.0	-0.117	-1000.0
Effects of Botulinum toxin	2.0	75.0	26.0	-0.109	0.012	1000.0	-1000.0	-0.069	-1000.0
IL27-mediated signaling events	2.0	135.0	51.0	-0.256	0.059	1000.0	-1000.0	-0.102	-1000.0
IL6-mediated signaling events	2.0	219.0	75.0	-0.148	0.058	1000.0	-1000.0	-0.109	-1000.0
TCGA08_retinoblastoma	2.0	22.0	8.0	-0.078	0.03	1000.0	-1000.0	-0.022	-1000.0
IGF1 pathway	2.0	133.0	57.0	-0.095	0.012	1000.0	-1000.0	-0.099	-1000.0
Angiopoietin receptor Tie2-mediated signaling	2.0	182.0	88.0	-0.224	0.08	1000.0	-1000.0	-0.123	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	2.0	313.0	120.0	-0.217	0.197	1000.0	-1000.0	-0.095	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	2.0	211.0	78.0	-0.119	0.086	1000.0	-1000.0	-0.095	-1000.0
ErbB2/ErbB3 signaling events	1.0	92.0	65.0	-0.134	0.022	1000.0	-1000.0	-0.081	-1000.0
Regulation of nuclear SMAD2/3 signaling	1.0	153.0	136.0	-0.121	0.119	1000.0	-1000.0	-0.074	-1000.0
Coregulation of Androgen receptor activity	1.0	128.0	76.0	-0.138	0.034	1000.0	-1000.0	-0.046	-1000.0
ErbB4 signaling events	1.0	130.0	69.0	-0.21	0.038	1000.0	-1000.0	-0.095	-1000.0
BARD1 signaling events	1.0	77.0	57.0	-0.107	0.085	1000.0	-1000.0	-0.075	-1000.0
JNK signaling in the CD4+ TCR pathway	1.0	23.0	17.0	-0.064	0.013	1000.0	-1000.0	-0.078	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	5.0	5.0	-0.018	0.002	1000.0	-1000.0	-0.034	-1000.0
IFN-gamma pathway	1.0	97.0	68.0	-0.152	0.021	1000.0	-1000.0	-0.105	-1000.0
Ceramide signaling pathway	1.0	78.0	76.0	-0.259	0.079	1000.0	-1000.0	-0.078	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	45.0	37.0	-0.179	0.024	1000.0	-1000.0	-0.064	-1000.0
Signaling events mediated by HDAC Class III	1.0	48.0	40.0	-0.115	0.022	1000.0	-1000.0	-0.046	-1000.0
S1P1 pathway	1.0	50.0	36.0	-0.187	0.012	1000.0	-1000.0	-0.062	-1000.0
FAS signaling pathway (CD95)	1.0	64.0	47.0	-0.182	0.014	1000.0	-1000.0	-0.052	-1000.0
Retinoic acid receptors-mediated signaling	1.0	108.0	58.0	-0.161	0.013	1000.0	-1000.0	-0.078	-1000.0
Syndecan-3-mediated signaling events	1.0	52.0	35.0	-0.185	0.012	1000.0	-1000.0	-0.068	-1000.0
EPHB forward signaling	1.0	167.0	85.0	-0.119	0.08	1000.0	-1000.0	-0.111	-1000.0
Nongenotropic Androgen signaling	1.0	83.0	52.0	-0.046	0.012	1000.0	-1000.0	-0.069	-1000.0
TCGA08_rtk_signaling	1.0	31.0	26.0	-0.096	0.032	1000.0	-1000.0	-0.024	-1000.0
Class I PI3K signaling events	1.0	91.0	73.0	-0.16	0.025	1000.0	-1000.0	-0.086	-1000.0
Regulation of Telomerase	1.0	160.0	102.0	-0.276	0.047	1000.0	-1000.0	-0.119	-1000.0
Plasma membrane estrogen receptor signaling	1.0	140.0	86.0	-0.094	0.018	1000.0	-1000.0	-0.093	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	41.0	33.0	-0.107	0.036	1000.0	-1000.0	-0.067	-1000.0
Rapid glucocorticoid signaling	1.0	24.0	20.0	-0.073	0.012	1000.0	-1000.0	-0.051	-1000.0
Signaling events mediated by PRL	1.0	48.0	34.0	-0.044	0.024	1000.0	-1000.0	-0.05	-1000.0
FOXM1 transcription factor network	1.0	56.0	51.0	-0.129	0.067	1000.0	-1000.0	-0.2	-1000.0
p38 MAPK signaling pathway	1.0	44.0	44.0	-0.152	0.018	1000.0	-1000.0	-0.074	-1000.0
Regulation of Androgen receptor activity	1.0	80.0	70.0	-0.251	0.039	1000.0	-1000.0	-0.072	-1000.0
Ras signaling in the CD4+ TCR pathway	1.0	24.0	17.0	-0.027	0.016	1000.0	-1000.0	-0.045	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	4.0	23.0	-0.022	0.045	1000.0	-1000.0	-0.083	-1000.0
Canonical NF-kappaB pathway	0.0	14.0	39.0	-0.043	0.07	1000.0	-1000.0	-0.098	-1000.0
Signaling events mediated by HDAC Class II	0.0	39.0	75.0	-0.048	0.03	1000.0	-1000.0	-0.073	-1000.0
Sphingosine 1-phosphate (S1P) pathway	0.0	21.0	28.0	-0.043	0.032	1000.0	-1000.0	-0.053	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	0.002	0.014	1000.0	-1000.0	-0.019	-1000.0
Circadian rhythm pathway	0.0	6.0	22.0	-0.015	0.046	1000.0	-1000.0	-0.065	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	0.0	65.0	85.0	-0.072	0.045	1000.0	-1000.0	-0.082	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	23.0	65.0	-0.042	0.047	1000.0	-1000.0	-0.073	-1000.0
Aurora A signaling	0.0	47.0	60.0	-0.155	0.032	1000.0	-1000.0	-0.067	-1000.0
Arf6 downstream pathway	0.0	13.0	43.0	-0.056	0.033	1000.0	-1000.0	-0.053	-1000.0
Aurora C signaling	0.0	6.0	7.0	-0.033	0.012	1000.0	-1000.0	-0.048	-1000.0
EPO signaling pathway	0.0	23.0	55.0	-0.048	0.07	1000.0	-1000.0	-0.102	-1000.0
PLK1 signaling events	0.0	0.0	85.0	-0.011	0.035	1000.0	-1000.0	-0.05	-1000.0
Insulin-mediated glucose transport	0.0	4.0	32.0	-0.009	0.042	1000.0	-1000.0	-0.075	-1000.0
mTOR signaling pathway	0.0	9.0	53.0	-0.006	0.029	1000.0	-1000.0	-0.066	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	6.0	68.0	-0.04	0.053	1000.0	-1000.0	-0.07	-1000.0
Nectin adhesion pathway	0.0	43.0	63.0	-0.031	0.044	1000.0	-1000.0	-0.083	-1000.0
TRAIL signaling pathway	0.0	27.0	48.0	-0.026	0.045	1000.0	-1000.0	-0.079	-1000.0
S1P5 pathway	0.0	10.0	17.0	-0.043	0.018	1000.0	-1000.0	-0.057	-1000.0
ceramide signaling pathway	0.0	9.0	49.0	-0.043	0.042	1000.0	-1000.0	-0.068	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	0.0	47.0	52.0	-0.099	0.025	1000.0	-1000.0	-0.072	-1000.0
HIF-2-alpha transcription factor network	0.0	32.0	43.0	-0.065	0.068	1000.0	-1000.0	-0.105	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	56.0	83.0	-0.164	0.043	1000.0	-1000.0	-0.08	-1000.0
Signaling events mediated by HDAC Class I	0.0	41.0	104.0	-0.043	0.048	1000.0	-1000.0	-0.083	-1000.0
FoxO family signaling	0.0	16.0	64.0	-0.058	0.129	1000.0	-1000.0	-0.075	-1000.0
Signaling mediated by p38-gamma and p38-delta	0.0	13.0	15.0	-0.04	0.023	1000.0	-1000.0	-0.037	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	16.0	36.0	-0.024	0.029	1000.0	-1000.0	-0.075	-1000.0
Atypical NF-kappaB pathway	0.0	9.0	31.0	-0.017	0.042	1000.0	-1000.0	-0.056	-1000.0
IL2 signaling events mediated by PI3K	0.0	26.0	58.0	-0.089	0.053	1000.0	-1000.0	-0.093	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	25.0	45.0	-0.043	0.063	1000.0	-1000.0	-0.103	-1000.0
Regulation of p38-alpha and p38-beta	0.0	50.0	54.0	-0.16	0.019	1000.0	-1000.0	-0.067	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	72.0	125.0	-0.053	0.069	1000.0	-1000.0	-0.105	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	0.0	56.0	74.0	-0.259	0.075	1000.0	-1000.0	-0.102	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	15.0	76.0	-0.058	0.062	1000.0	-1000.0	-0.092	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	-0.005	0.029	1000.0	-1000.0	-0.061	-1000.0
IL2 signaling events mediated by STAT5	0.0	19.0	22.0	-0.086	0.04	1000.0	-1000.0	-0.056	-1000.0
Arf6 trafficking events	0.0	22.0	71.0	-0.051	0.041	1000.0	-1000.0	-0.094	-1000.0
Insulin Pathway	0.0	65.0	74.0	-0.169	0.034	1000.0	-1000.0	-0.103	-1000.0
VEGFR1 specific signals	0.0	13.0	56.0	-0.032	0.049	1000.0	-1000.0	-0.086	-1000.0
S1P3 pathway	0.0	37.0	42.0	-0.043	0.025	1000.0	-1000.0	-0.061	-1000.0
PDGFR-beta signaling pathway	0.0	63.0	97.0	-0.116	0.052	1000.0	-1000.0	-0.097	-1000.0
E-cadherin signaling in keratinocytes	0.0	3.0	43.0	-0.007	0.05	1000.0	-1000.0	-0.077	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.012	0.012	1000.0	-1000.0	-0.019	-1000.0
S1P4 pathway	0.0	17.0	25.0	-0.043	0.012	1000.0	-1000.0	-0.061	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.0	0.012	1000.0	-1000.0	-0.046	-1000.0
Arf1 pathway	0.0	5.0	54.0	-0.028	0.026	1000.0	-1000.0	-0.052	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.012	1000.0	-1000.0	-0.074	-1000.0
Aurora B signaling	0.0	45.0	67.0	-0.16	0.035	1000.0	-1000.0	-0.089	-1000.0
Total	241	17680	7203	-20.4616534451	6.13153873384	131000	-131000	-10.5581904239	-131000