Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IHH 0.041 0.002 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.151 0.123 -9999.0 0.0 -0.238 46.0 46.0 LRPAP1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.15 0.123 0.236 46.0 -9999.0 0.0 46.0 SMO/beta Arrestin2 0.046 0.052 -9999.0 0.0 -9999.0 0.0 0.0 SMO 0.029 0.037 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.006 0.108 -9999.0 0.0 -0.328 1.0 1.0 ARRB2 0.026 0.013 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.007 0.129 -9999.0 0.0 -0.424 6.0 6.0 ADRBK1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.029 0.037 -9999.0 0.0 -9999.0 0.0 0.0 STIL 0.001 0.075 0.353 1.0 -9999.0 0.0 1.0 DHH N/PTCH2 0.046 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.052 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.03 0.015 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry 0.029 0.037 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.03 0.015 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip -0.033 0.159 -9999.0 0.0 -0.334 15.0 15.0 DHH N/Hhip -0.031 0.144 -9999.0 0.0 -0.304 15.0 15.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.029 0.037 -9999.0 0.0 -9999.0 0.0 0.0 pancreas development -0.067 0.188 -9999.0 0.0 -0.423 15.0 15.0 HHAT 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.047 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.298 0.204 -9999.0 0.0 -0.424 50.0 50.0 somite specification 0.029 0.037 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH1 0.032 0.02 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/PTCH2 0.025 0.02 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin 0.023 0.024 -9999.0 0.0 -9999.0 0.0 0.0 SHH -0.016 0.016 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process 0.037 0.008 -9999.0 0.0 -9999.0 0.0 0.0 SMO/Vitamin D3 0.03 0.033 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Hhip -0.031 0.112 -9999.0 0.0 -0.243 15.0 15.0 LRP2 0.03 0.023 -9999.0 0.0 -0.158 1.0 1.0 receptor-mediated endocytosis 0.025 0.028 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/BOC 0.007 0.076 -9999.0 0.0 -0.26 5.0 5.0 SHH Np/Cholesterol/CDO 0.017 0.049 -9999.0 0.0 -0.235 2.0 2.0 mesenchymal cell differentiation 0.031 0.112 0.242 15.0 -9999.0 0.0 15.0 mol:Vitamin D3 0.043 0.059 0.375 1.0 -9999.0 0.0 1.0 IHH N/PTCH2 0.052 0.001 -9999.0 0.0 -9999.0 0.0 0.0 CDON 0.019 0.077 -9999.0 0.0 -0.424 2.0 2.0 IHH N/PTCH1 0.048 0.01 -9999.0 0.0 -9999.0 0.0 0.0 Megalin/LRPAP1 0.046 0.019 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.033 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.013 0.016 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 0.037 0.008 -9999.0 0.0 -9999.0 0.0 0.0 HHIP -0.067 0.188 -9999.0 0.0 -0.424 15.0 15.0