Clinical Features CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nMutated (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Chi-square test_P Chi-square test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q C15ORF23 14 (6%) 214 0.26206 1 0.2455 1 0.86034 1 0.82559 1 0.78415 1 1 1 0.7757 1 0.77911 1 0.34424 1 0.59351 1 CDKN2A 33 (14%) 195 0.68445 1 0.2748 1 0.37395 1 0.78937 1 0.89011 1 0.47865 1 0.73995 1 0.7308 1 1 1 0.80772 1 NRAS 67 (29%) 161 0.45279 1 0.10977 1 0.092324 1 0.32888 1 0.96562 1 0.85837 1 0.85029 1 0.82882 1 0.72892 1 0.75709 1 BRAF 117 (51%) 111 0.0054849 1 0.053048 1 0.031116 1 0.0098264 1 0.031391 1 8.8803e-05 0.0785 0.23133 1 0.15416 1 0.48626 1 0.27962 1 OXA1L 7 (3%) 221 1 1 0.4355 1 0.61495 1 0.47172 1 0.50301 1 0.27586 1 0.61758 1 0.62738 1 0.72353 1 0.323 1 TP53 35 (15%) 193 0.050094 1 0.026916 1 0.31446 1 0.13834 1 0.22544 1 0.45799 1 0.3756 1 0.12067 1 0.6767 1 0.053754 1 STK19 11 (5%) 217 0.86139 1 0.13712 1 0.22397 1 0.99881 1 0.86136 1 0.36214 1 0.5773 1 0.6046 1 0.18997 1 0.71589 1 PTEN 18 (8%) 210 0.8637 1 0.203 1 0.14937 1 0.13056 1 0.90814 1 0.062529 1 0.81862 1 0.32341 1 0.60931 1 0.39565 1 DSG1 39 (17%) 189 0.29872 1 0.5228 1 0.08594 1 0.068532 1 0.30763 1 0.75837 1 0.21446 1 0.43804 1 0.56904 1 0.59483 1 PPP6C 18 (8%) 210 0.45394 1 0.2682 1 0.099245 1 0.79008 1 0.55766 1 0.65317 1 0.34522 1 0.11301 1 0.23193 1 0.45804 1 RAC1 17 (7%) 211 0.29939 1 0.73377 1 0.94006 1 0.46967 1 0.51222 1 0.84872 1 0.58235 1 0.32079 1 0.13672 1 0.20282 1 AOAH 21 (9%) 207 0.77392 1 0.1772 1 0.72746 1 0.30359 1 0.50432 1 0.3362 1 0.7322 1 0.56036 1 0.77423 1 0.72862 1 IDH1 12 (5%) 216 0.029304 1 0.33661 1 0.089075 1 0.2525 1 0.31708 1 0.79481 1 0.15989 1 0.11542 1 0.13573 1 0.033239 1 OR51S1 27 (12%) 201 0.51974 1 0.96598 1 0.88427 1 0.10846 1 0.38292 1 0.68998 1 0.63031 1 0.87135 1 0.51484 1 0.23946 1 IL32 9 (4%) 219 0.58196 1 0.12675 1 0.68761 1 0.14582 1 0.52776 1 1 1 0.62869 1 1 1 0.69048 1 0.88386 1 PPIAL4G 12 (5%) 216 0.1305 1 0.80566 1 0.66321 1 0.30083 1 0.17253 1 0.6855 1 0.80606 1 0.56932 1 0.2023 1 0.73889 1 UGT2B15 21 (9%) 207 0.6248 1 0.36536 1 0.81502 1 0.73987 1 0.43859 1 0.8728 1 0.15091 1 0.34473 1 0.063222 1 0.20127 1 TTN 176 (77%) 52 0.34105 1 0.014376 1 0.49483 1 0.11376 1 0.19811 1 0.21998 1 0.11917 1 0.3143 1 0.072913 1 0.61591 1 THEMIS 27 (12%) 201 0.70849 1 0.01906 1 0.35918 1 0.26627 1 0.66472 1 0.43888 1 0.03749 1 0.51761 1 0.51484 1 0.23946 1 LRTM1 23 (10%) 205 0.025416 1 0.7559 1 0.85854 1 0.72082 1 0.96235 1 1 1 0.66753 1 0.62174 1 0.96127 1 0.26363 1 TCEB3C 26 (11%) 202 0.70152 1 0.33271 1 0.3631 1 0.55651 1 0.30832 1 0.042814 1 0.66648 1 0.25162 1 1 1 0.054399 1 ELF5 6 (3%) 222 0.58381 1 1 1 0.93438 1 0.5189 1 0.59009 1 1 1 0.2044 1 0.15658 1 0.44026 1 0.25672 1 GPR141 14 (6%) 214 0.014263 1 0.38789 1 0.10049 1 0.046979 1 0.8856 1 0.50861 1 0.11709 1 0.92091 1 0.17738 1 1 1 NMNAT3 8 (4%) 220 0.22434 1 0.74575 1 0.29133 1 0.30896 1 0.81969 1 0.89387 1 0.5303 1 0.090459 1 0.35216 1 0.11455 1 EIF2B1 9 (4%) 219 0.8343 1 0.52784 1 0.080882 1 0.27551 1 0.63584 1 1 1 0.31524 1 0.68787 1 0.31972 1 0.57631 1 CHGB 25 (11%) 203 0.4945 1 0.63807 1 0.15834 1 0.29706 1 0.11509 1 0.88964 1 0.92787 1 0.15766 1 0.45955 1 0.28961 1 COPG2 9 (4%) 219 0.63522 1 0.91342 1 0.27075 1 0.25968 1 0.69183 1 0.61403 1 0.90742 1 0.77943 1 0.57195 1 1 1 RAPGEF5 12 (5%) 216 0.93212 1 0.60651 1 0.62719 1 0.50272 1 0.49083 1 0.6855 1 0.23841 1 0.062404 1 0.086056 1 0.12125 1 MS4A2 10 (4%) 218 0.081977 1 1 1 0.095928 1 0.75198 1 0.78222 1 0.39578 1 0.50502 1 0.34634 1 0.66225 1 0.53039 1 MPP7 25 (11%) 203 0.39561 1 0.74178 1 0.94478 1 0.54381 1 0.11073 1 0.50282 1 0.5026 1 0.67278 1 1 1 0.69036 1 C1QTNF9 14 (6%) 214 0.8328 1 0.6095 1 0.079388 1 0.87005 1 0.94064 1 0.67269 1 0.4039 1 0.18192 1 0.47625 1 0.32184 1 DNAH7 83 (36%) 145 0.86798 1 0.58003 1 0.54825 1 0.33821 1 0.71869 1 0.74638 1 0.72247 1 0.86251 1 0.52187 1 0.95543 1 FAM58A 5 (2%) 223 0.37875 1 0.84776 1 0.61495 1 0.47172 1 0.23011 1 0.43895 1 0.20873 1 0.30293 1 0.23111 1 0.25567 1 LCE1B 12 (5%) 216 0.03224 1 0.60651 1 0.3173 1 0.85812 1 0.57116 1 0.79481 1 0.92949 1 0.91004 1 0.39072 1 0.90166 1 SCN5A 57 (25%) 171 0.98092 1 0.6877 1 0.076907 1 0.90452 1 0.47536 1 0.80765 1 0.60651 1 0.83379 1 0.82321 1 0.73359 1 C6ORF223 4 (2%) 224 0.83468 1 0.2387 1 0.054842 1 0.58195 1 0.463 1 0.54803 1 0.36171 1 1 1 0.38995 1 1 1 ANKRD20A4 5 (2%) 223 0.05211 1 0.45007 1 0.31977 1 0.14289 1 0.23011 1 0.60444 1 0.61552 1 1 1 0.33282 1 1 1 LOC649330 24 (11%) 204 0.46603 1 0.47554 1 0.77989 1 0.74046 1 0.049979 1 0.53671 1 0.75988 1 0.66461 1 0.96218 1 0.64464 1 KLRC3 10 (4%) 218 0.47282 1 0.65016 1 0.49539 1 0.012588 1 0.60805 1 0.10998 1 0.24242 1 1 1 0.034409 1 1 1 UNC119B 6 (3%) 222 0.2071 1 0.45148 1 0.21258 1 0.91979 1 0.59009 1 0.55071 1 1 1 0.46189 1 0.77214 1 0.81305 1 PENK 20 (9%) 208 0.15275 1 0.044865 1 0.77949 1 0.65432 1 0.048061 1 0.16404 1 0.52358 1 0.69795 1 0.17232 1 0.42878 1 OR4E2 20 (9%) 208 0.15275 1 0.76271 1 0.55782 1 0.63354 1 0.3889 1 0.78655 1 0.87057 1 1 1 0.58545 1 0.82486 1 TSHB 5 (2%) 223 0.53375 1 0.45007 1 NA NA NA NA 0.27459 1 0.60444 1 1 1 1 1 0.86511 1 1 1 PRC1 13 (6%) 215 0.87765 1 0.48149 1 0.059666 1 0.7173 1 0.32043 1 0.52173 1 0.31241 1 0.54073 1 0.27588 1 0.82177 1 SORT1 10 (4%) 218 0.7773 1 0.77831 1 1 1 0.49761 1 0.25294 1 0.16637 1 1 1 0.50993 1 0.54664 1 0.29987 1 PCDP1 15 (7%) 213 0.62831 1 0.13179 1 0.57835 1 0.87618 1 0.33218 1 0.40402 1 0.37926 1 0.23386 1 0.6316 1 0.28898 1 ZFP106 10 (4%) 218 0.12021 1 0.77831 1 0.23403 1 0.25731 1 0.50932 1 0.91706 1 0.55085 1 0.44694 1 1 1 0.46132 1 TCHHL1 31 (14%) 197 0.30898 1 0.077502 1 0.027894 1 0.0031375 1 0.1158 1 0.12058 1 0.54765 1 0.51277 1 0.96972 1 0.3213 1 OR2W1 17 (7%) 211 0.11506 1 0.65826 1 0.24078 1 0.085442 1 0.72272 1 0.9424 1 0.36154 1 0.81353 1 0.43438 1 0.73954 1 LRRC4C 33 (14%) 195 0.089943 1 0.50304 1 0.52828 1 0.35156 1 0.36994 1 0.47865 1 0.65803 1 0.62613 1 0.91613 1 0.21757 1 SERPINB10 13 (6%) 215 0.1982 1 0.87853 1 0.43276 1 0.86188 1 0.77054 1 0.81156 1 0.4099 1 0.91364 1 0.82162 1 0.68805 1 C18ORF26 14 (6%) 214 0.54137 1 0.82732 1 0.69391 1 0.3791 1 0.16977 1 0.67269 1 0.93948 1 0.27813 1 0.41766 1 0.28728 1 TBC1D3B 5 (2%) 223 0.37875 1 0.84776 1 0.059099 1 0.24109 1 0.86106 1 1 1 0.85305 1 0.64053 1 0.73617 1 0.47246 1 CCNE2 12 (5%) 216 0.65697 1 0.80566 1 0.55123 1 0.21121 1 0.10697 1 0.073678 1 0.023275 1 0.27464 1 0.0056942 1 0.22523 1 CAPZA3 17 (7%) 211 0.45759 1 0.11327 1 0.32859 1 0.95787 1 0.95019 1 0.75788 1 0.69267 1 0.53094 1 0.62797 1 0.63632 1 PROL1 21 (9%) 207 0.44039 1 0.060589 1 0.2237 1 0.19997 1 0.84591 1 0.68659 1 0.30111 1 0.36572 1 0.46089 1 0.13753 1 CYP4X1 16 (7%) 212 0.18264 1 0.94546 1 0.45585 1 0.13871 1 0.80444 1 1 1 1 1 0.68794 1 0.8969 1 0.67526 1 GCOM1 21 (9%) 207 1 1 0.39695 1 0.52185 1 0.63991 1 0.037609 1 0.22958 1 0.7322 1 0.592 1 0.50202 1 0.3414 1 DGAT2L6 11 (5%) 217 0.19815 1 0.53656 1 0.88467 1 0.11987 1 0.24283 1 0.60541 1 0.78915 1 0.81023 1 0.18997 1 0.49937 1 EIF3D 4 (2%) 224 0.68103 1 0.83761 1 0.2405 1 0.4188 1 1 1 0.36076 1 0.56615 1 0.4292 1 0.30952 1 1 1 B2M 5 (2%) 223 1 1 0.84776 1 0.87032 1 0.99227 1 0.44609 1 0.60444 1 0.058337 1 0.16397 1 0.61715 1 0.3578 1 KCNB2 52 (23%) 176 0.038711 1 0.010877 1 0.56922 1 0.39547 1 0.31538 1 0.33001 1 0.64028 1 0.55844 1 0.32464 1 0.94283 1 KIAA2022 44 (19%) 184 0.95442 1 0.51471 1 0.51094 1 0.5858 1 0.24548 1 0.58646 1 0.43151 1 0.50422 1 0.58444 1 0.073084 1 C9ORF119 8 (4%) 220 0.1997 1 0.5977 1 0.47592 1 0.5596 1 0.66474 1 0.38725 1 0.24689 1 0.30408 1 0.17861 1 0.43553 1 TUBAL3 10 (4%) 218 0.5127 1 0.77831 1 0.86613 1 0.43262 1 0.78222 1 0.58505 1 0.84478 1 0.64061 1 0.78621 1 0.79489 1 NUDT4 5 (2%) 223 0.74169 1 0.37304 1 0.35693 1 0.15084 1 1 1 0.83746 1 0.53002 1 0.49838 1 0.5208 1 0.3578 1 C2 12 (5%) 216 0.095613 1 0.31035 1 0.054874 1 0.39523 1 0.0989 1 0.58018 1 0.45023 1 0.41483 1 0.21742 1 0.66329 1 KIAA1486 25 (11%) 203 0.36729 1 0.059099 1 0.64293 1 0.77167 1 0.38027 1 0.72443 1 0.3701 1 1 1 0.92918 1 0.85384 1 APCS 11 (5%) 217 1 1 0.11831 1 0.39986 1 0.25042 1 0.63354 1 0.29606 1 0.85666 1 0.18734 1 0.49817 1 0.56939 1 SIRPB1 18 (8%) 210 0.20103 1 0.74159 1 0.25833 1 0.20706 1 0.039199 1 0.15206 1 0.70092 1 0.12211 1 0.71118 1 0.20544 1 CYP7B1 18 (8%) 210 0.016214 1 0.57921 1 0.57389 1 0.27567 1 0.37245 1 0.9489 1 0.39828 1 0.50969 1 0.25427 1 0.8672 1 SGCZ 22 (10%) 206 0.49559 1 0.43255 1 0.81211 1 0.71689 1 0.7834 1 0.13335 1 0.81097 1 0.89473 1 0.14963 1 0.61659 1 PDE1A 32 (14%) 196 0.50164 1 0.91344 1 0.4751 1 0.40562 1 0.036085 1 0.22813 1 0.52296 1 0.29864 1 0.082419 1 0.13608 1 CYP4Z1 19 (8%) 209 0.47144 1 0.099194 1 0.2005 1 0.68881 1 0.26372 1 0.038549 1 1 1 0.82981 1 0.91141 1 0.57292 1 FAM113B 20 (9%) 208 0.63915 1 0.41963 1 0.14657 1 0.75741 1 0.23473 1 0.24251 1 0.34125 1 0.74273 1 0.28198 1 0.42878 1 SLC10A2 20 (9%) 208 0.8 1 0.15365 1 0.74751 1 0.32811 1 0.16043 1 0.61529 1 0.47811 1 0.14493 1 0.38364 1 0.15698 1 CX3CL1 4 (2%) 224 1 1 0.18617 1 NA NA NA NA 1 1 0.54803 1 0.12235 1 0.4292 1 0.38995 1 0.39671 1 C2ORF39 9 (4%) 219 0.26172 1 0.236 1 0.86613 1 0.26974 1 0.032245 1 0.017989 1 0.50336 1 0.88929 1 0.83623 1 0.66923 1 IGF2BP3 6 (3%) 222 0.77057 1 0.77062 1 0.86573 1 0.65943 1 0.51788 1 1 1 0.17364 1 0.71353 1 0.28954 1 0.66585 1 SLC9A11 36 (16%) 192 0.086988 1 0.089307 1 0.60167 1 0.73725 1 0.58156 1 0.83772 1 0.080934 1 0.48147 1 0.11805 1 0.82349 1 HRNR 48 (21%) 180 0.75376 1 0.58754 1 0.75615 1 0.69585 1 0.91763 1 0.57872 1 0.1555 1 0.42677 1 0.1357 1 0.80356 1 FIGLA 3 (1%) 225 0.78119 1 0.62446 1 NA NA NA NA 0.51401 1 0.42936 1 0.47226 1 0.68966 1 0.1163 1 0.46667 1 DDX3X 18 (8%) 210 0.34971 1 0.95128 1 0.23055 1 0.17631 1 0.67589 1 0.9489 1 0.86179 1 0.20807 1 0.78283 1 0.59942 1 TRHDE 41 (18%) 187 0.34422 1 0.48536 1 0.83162 1 0.12788 1 0.61245 1 0.82816 1 0.75721 1 0.60947 1 0.30397 1 0.29767 1 SPTLC3 17 (7%) 211 0.59573 1 0.3087 1 0.494 1 0.86118 1 0.0047195 1 0.4283 1 0.3412 1 0.39709 1 0.4093 1 0.24575 1 ACD 9 (4%) 219 0.43724 1 0.82889 1 0.47 1 0.54089 1 0.39436 1 0.13765 1 0.086231 1 0.058432 1 0.52667 1 0.10604 1 ARL16 7 (3%) 221 0.63087 1 0.34553 1 0.13778 1 0.63649 1 0.39107 1 1 1 1 1 1 1 0.26593 1 0.70275 1 PHGDH 9 (4%) 219 0.35191 1 0.91342 1 1 1 0.43302 1 0.76257 1 0.74674 1 0.7657 1 0.3496 1 1 1 0.49402 1 DNER 22 (10%) 206 0.042892 1 0.53392 1 0.77949 1 0.1252 1 0.88362 1 0.5809 1 0.42672 1 0.5747 1 0.18708 1 0.24777 1