rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(10) 240807 10 10 10 2 7 1 1 1 0 0 0.124 0.106 1.000 2 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(4) 172740 4 4 4 1 4 0 0 0 0 0 0.482 0.464 1.000 3 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 CDK5(4), FOSB(5), GRIA2(34), JUND(1), PPP1R1B(2) 1226014 46 39 43 15 28 3 2 6 7 0 0.0690 0.824 1.000 4 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(6), GOT2(5), TAT(17) 883649 28 18 27 7 21 2 2 1 2 0 0.0148 0.880 1.000 5 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(6), DCN(17), FMOD(4), KERA(14), LUM(11) 1178331 52 38 48 16 41 4 3 1 3 0 0.00183 0.885 1.000 6 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(4), IL8(1), SLPI(6) 576974 11 11 11 4 5 1 0 4 1 0 0.437 0.917 1.000 7 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(5), CHRNA1(5), SNAP25(6), STX1A(2) 1097766 18 15 15 3 12 1 0 1 4 0 0.0101 0.944 1.000 8 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(2), LIPT1(2) 519728 4 3 4 0 0 2 0 1 1 0 0.334 0.952 1.000 9 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 6 ADH1A(14), ADH1B(27), ADH4(11), ADH6(11), ADH7(13), ADHFE1(5) 1631130 81 59 69 24 65 4 5 5 2 0 0.00400 0.956 1.000 10 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(3), ALDOA(2), ALDOB(12), ALDOC(3) 1324868 20 15 17 4 15 2 0 1 2 0 0.0140 0.972 1.000 11 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(3) 556442 3 3 2 1 2 0 0 1 0 0 0.552 0.984 1.000 12 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(5), CD3E(2), CD3G(1) 377095 8 6 8 5 7 0 0 0 1 0 0.701 0.993 1.000 13 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA1(13), CCND1(1), CCNE1(4), CCNE2(12), CDK4(5), CDKN1B(1), E2F1(5), E2F2(4), E2F4(1), PRB1(29) 2814031 75 54 67 16 51 0 4 17 3 0 0.00145 0.994 1.000 14 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(7), SEC61A2(7), SRP19(6), SRP54(3), SRP68(7), SRP72(1), SRP9(1), SRPR(2) 2568197 34 28 30 8 14 0 3 10 7 0 0.195 0.998 1.000 15 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 CCND1(1), CDK4(5), CDKN1A(4), CDKN1B(1), CFL1(1), E2F1(5), E2F2(4), MDM2(3), NXT1(2), PRB1(29) 2351186 55 39 51 14 35 3 2 11 4 0 0.00929 0.999 1.000 16 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(2), CASP3(2), CASP8(8), CFL1(1), CFLAR(4), PDE6D(2) 1311615 19 17 19 7 8 1 2 6 2 0 0.523 1.000 1.000 17 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(2), TGDS(1), UGDH(1), UXS1(4) 1296567 8 8 8 9 3 0 1 0 4 0 0.985 1.000 1.000 18 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(3), ECHS1(2), EHHADH(6), HADHA(8), SDS(2) 1624136 21 19 19 8 13 2 0 5 1 0 0.244 1.000 1.000 19 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYB(3), NFYC(1), RB1(8), SP1(5), SP3(1) 2236930 19 16 19 5 2 2 2 6 5 2 0.349 1.000 1.000 20 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(4), ALDH1A2(11), BCMO1(15), RDH5(2) 1310017 32 28 29 11 22 2 1 4 3 0 0.0561 1.000 1.000 21 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(4), IFNG(2), IL12A(3), IL12B(3), IL18(2), IL2(4) 986629 18 9 18 7 12 2 0 2 2 0 0.258 1.000 1.000 22 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(4), NFKB1(7), NFKBIA(2), PLCB1(48), PRKCA(10), RELA(4) 2743472 75 54 70 25 58 3 2 7 5 0 0.0274 1.000 1.000 23 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(3), IDI1(1), SQLE(4) 1066021 8 8 8 3 4 1 1 2 0 0 0.478 1.000 1.000 24 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(4), ACADM(5), ACADS(4), ECHS1(2), HADHA(8) 1842666 23 21 23 7 14 2 1 6 0 0 0.263 1.000 1.000 25 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(2), BCKDK(2), CBS(6), CTH(1), MUT(5) 1707246 16 16 16 6 10 2 1 2 1 0 0.356 1.000 1.000 26 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(3), HLCS(6) 1038760 9 9 9 9 6 0 1 1 1 0 0.913 1.000 1.000 27 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(13), GAD1(13), HDC(19), PNMT(4), TH(9), TPH1(5) 1997200 63 47 60 26 52 2 2 2 5 0 0.0110 1.000 1.000 28 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(11), LPL(3), NR3C1(7), PPARG(11), RETN(3), RXRA(4), TNF(1) 1954008 40 32 38 14 27 2 0 6 5 0 0.0644 1.000 1.000 29 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(1), ECHS1(2), EHHADH(6), GCDH(5), HADHA(8), SDHB(1), SDS(2) 2619327 25 21 24 8 17 3 0 4 1 0 0.131 1.000 1.000 30 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(1), HMGCL(4), OXCT1(4) 1128896 9 9 9 5 6 1 0 1 1 0 0.721 1.000 1.000 31 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(4), MTMR2(2), MTMR6(2), NFS1(3), TPK1(8) 2144617 20 18 19 7 14 1 2 1 1 1 0.383 1.000 1.000 32 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(3), MMP14(2), MMP2(7), MMP9(7), RECK(11), TIMP1(1), TIMP2(1), TIMP3(5), TIMP4(6) 2489661 43 35 41 14 25 3 2 10 3 0 0.0792 1.000 1.000 33 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCR3(10), CSF2(2), HLA-DRA(11), HLA-DRB1(3), IL3(3), IL5(4) 1015009 34 26 33 16 28 1 0 3 2 0 0.0677 1.000 1.000 34 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(2), GLS2(3), GLUD1(2), GLUD2(4) 1523529 11 9 11 7 3 3 1 1 3 0 0.801 1.000 1.000 35 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 CAMP(1), DAG1(5), GNAQ(4), ITPKB(6) 2011071 16 16 16 7 11 0 1 1 3 0 0.308 1.000 1.000 36 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(12), GOT1(6), GOT2(5), TAT(17), TYR(8) 1576532 48 30 47 20 36 4 3 1 4 0 0.112 1.000 1.000 37 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(4), CDC34(4), CUL1(5), E2F1(5), FBXW7(11), RB1(8), TFDP1(2) 2727106 39 31 38 12 16 2 5 6 8 2 0.129 1.000 1.000 38 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(4), RAB11A(1), RAB1A(1), RAB27A(3), RAB3A(2), RAB5A(1) 1413500 12 10 12 6 9 1 1 1 0 0 0.515 1.000 1.000 39 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(11), IARS(8), LARS(10), LARS2(4), PDHA1(3), PDHA2(17), PDHB(1) 3377570 54 39 50 13 36 6 1 6 5 0 0.0190 1.000 1.000 40 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(5), AASDHPPT(3), AASS(3), KARS(4) 1559878 15 15 15 5 13 0 0 2 0 0 0.381 1.000 1.000 41 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CSF2(2), CSF3(4), EPO(5), FLT3(31), IGF1(11), IL11(2), IL1A(4), IL3(3), IL6(2), IL9(1), KITLG(8), TGFB1(1), TGFB2(1), TGFB3(3) 2757762 78 51 73 29 51 7 4 10 6 0 0.0154 1.000 1.000 42 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(3), ACP2(2), ACP5(3), ACPP(8), ENPP1(11), ENPP3(14), FLAD1(9), TYR(8) 3236729 58 42 56 16 37 5 2 5 9 0 0.0201 1.000 1.000 43 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(9), PARK2(8), SNCA(2), SNCAIP(47), UBE2E2(4), UBE2F(4), UBE2G2(1), UBE2L6(2) 2156876 77 56 70 26 58 9 1 4 5 0 0.0245 1.000 1.000 44 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(5), ALAS1(1), ALAS2(5), CPOX(4), FECH(3), HMBS(1), PPOX(3), UROS(1) 2536645 23 20 23 9 15 2 1 2 3 0 0.256 1.000 1.000 45 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(5), PSMA2(1), PSMA4(1), PSMA5(3), PSMA6(4), PSMB1(1), PSMB10(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMB8(5) 2958849 27 21 27 9 14 2 2 6 3 0 0.342 1.000 1.000 46 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(8), CDC25B(4), CDKN1A(4), CHEK1(2), NEK1(8), WEE1(2) 2324381 28 22 28 7 14 5 1 4 4 0 0.164 1.000 1.000 47 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 11 ACTA1(4), ACTR2(3), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(2), WASF1(4), WASL(5) 2585798 26 22 26 8 16 2 1 3 4 0 0.208 1.000 1.000 48 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(3), GGPS1(1), IDI1(1), IDI2(1), SQLE(4) 1425377 10 10 10 5 6 1 1 2 0 0 0.588 1.000 1.000 49 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(3), PLCD1(3), PRKCA(10), TGM2(8) 1666546 24 18 23 10 19 2 0 0 3 0 0.0483 1.000 1.000 50 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(2), HADHA(8), HADHB(4), HSD17B10(2), HSD17B4(6), MECR(5), PPT1(4), PPT2(8) 2845585 40 38 38 14 17 4 4 12 3 0 0.277 1.000 1.000 51 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(14), NR0B2(6), NR1H3(3), NR1H4(13), RXRA(4) 1822148 40 28 40 15 25 7 3 2 3 0 0.0380 1.000 1.000 52 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(6), BAX(3), BCL10(3), BCL2(2), BCL2L11(5), CASP8AP2(7), CASP9(3), CES1(16) 3615720 45 32 44 13 28 6 2 3 6 0 0.0919 1.000 1.000 53 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(8), ALPL(9), ALPP(9), ALPPL2(11), FPGS(3), GGH(2), SPR(2) 2132193 44 31 41 18 35 5 2 1 1 0 0.0216 1.000 1.000 54 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(13), CCNE1(4), CDC34(4), CUL1(5), E2F1(5), RB1(8), SKP2(2), TFDP1(2) 2852159 43 35 43 15 24 2 4 6 5 2 0.115 1.000 1.000 55 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(4), DPM2(1), EGR1(4), HRAS(3), KLK2(2), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), NGFR(7), RAF1(8) 2713240 47 41 41 22 24 4 2 10 7 0 0.262 1.000 1.000 56 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(2), CASP7(4), DFFA(2), DFFB(3), GZMB(3), HMGB1(1), HMGB2(1), TOP2A(10), TOP2B(8) 2999482 34 26 34 10 22 1 4 5 2 0 0.232 1.000 1.000 57 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(3), ECHS1(2), EHHADH(6), HADHA(8), HSD17B10(2), HSD17B4(6), NTAN1(1), SIRT2(1), SIRT5(7), SIRT7(2), VNN2(14) 3970064 52 41 50 14 33 5 3 9 2 0 0.0269 1.000 1.000 58 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(9), CS(2), MDH1(1), ME1(19), PC(12), PDHA1(3), SLC25A11(2) 3123056 48 34 47 19 28 5 2 9 4 0 0.0811 1.000 1.000 59 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), CYCS(1), GPD2(2), SDHA(1), SDHB(1), SDHC(2), SDHD(1), UQCRC1(3) 2230829 12 12 12 5 8 0 1 1 2 0 0.477 1.000 1.000 60 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(1), MYC(5), SP1(5), SP3(1), WT1(5) 2102838 17 15 17 7 9 2 3 2 1 0 0.549 1.000 1.000 61 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(5), AASDH(5), AASDHPPT(3), AASS(3), KARS(4) 2313755 20 18 20 7 17 0 0 2 1 0 0.392 1.000 1.000 62 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(3), ACP2(2), ACP5(3), ACP6(11), ACPP(8), ENPP1(11), ENPP3(14), FLAD1(9), LHPP(1), MTMR1(4), MTMR2(2), MTMR6(2), TYR(8) 5021300 78 51 75 20 49 6 6 7 10 0 0.00523 1.000 1.000 63 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(9), CTH(1), GOT1(6), GOT2(5), LDHA(5), LDHB(2), LDHC(5), MPST(2) 2303403 35 27 33 13 26 1 5 2 1 0 0.118 1.000 1.000 64 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(3), PAPSS2(5), SULT1A2(2), SULT1E1(12), SULT2A1(7), SUOX(4) 2044636 33 19 32 11 26 1 0 2 4 0 0.105 1.000 1.000 65 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(2), NDUFA4(1), NDUFB2(3), NDUFB5(3), NDUFB6(2), NDUFS2(2), NDUFV1(2) 2347626 15 15 15 6 10 0 1 3 1 0 0.551 1.000 1.000 66 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(11), COASY(3), DPYD(56), DPYS(22), ENPP1(11), ENPP3(14), PANK1(2), PANK2(3), PANK3(3), PANK4(6), PPCS(3), UPB1(6) 4653241 140 79 126 38 100 10 4 16 10 0 0.000218 1.000 1.000 67 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(9), CARS2(2), CDO1(5), CTH(1), GOT1(6), GOT2(5), LDHA(5), LDHAL6A(4), LDHAL6B(7), LDHB(2), LDHC(5), MPST(2), SDS(2), SULT1B1(11), SULT1C2(5), SULT1C4(12), SULT4A1(8) 4209458 91 60 87 29 63 3 9 7 9 0 0.00385 1.000 1.000 68 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(4), ENO2(4), ENO3(4), FARS2(4), GOT1(6), GOT2(5), PAH(8), TAT(17), YARS(1) 2799697 53 39 50 21 40 5 2 3 3 0 0.0250 1.000 1.000 69 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(6), CPS1(21), GLS(2), GLUD1(2), GOT1(6) 2558390 38 27 36 15 24 3 2 7 2 0 0.248 1.000 1.000 70 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(4), CDKN1B(1), CUL1(5), E2F1(5), NEDD8(1), RB1(8), SKP2(2), TFDP1(2), UBE2M(1) 2879255 29 28 29 12 11 2 4 4 6 2 0.355 1.000 1.000 71 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(3), AKT2(8), AKT3(4), CDKN1A(4), ELK1(2), GRB2(2), HRAS(3), MAP2K1(10), MAP2K2(3), NGFR(7), NTRK1(15), PIK3CA(8), PIK3CD(7), SHC1(1), SOS1(8) 5331617 85 59 78 28 42 13 2 18 10 0 0.0492 1.000 1.000 72 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(6), CD8A(2), CSF1(10), CSF2(2), CSF3(4), EPO(5), IL11(2), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(5), IL8(1), IL9(1) 2024094 52 35 51 28 37 4 1 4 6 0 0.125 1.000 1.000 73 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(4), FARSA(6), FARSB(5), GOT1(6), GOT2(5), PAH(8), TAT(17), YARS(1), YARS2(2) 2921402 54 39 51 22 39 6 2 2 5 0 0.0514 1.000 1.000 74 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(6), BAX(3), BCL2(2), BIK(2), BIRC2(5), BIRC3(7), CASP3(2), CASP7(4), CASP8(8), CASP9(3), CYCS(1), DFFA(2), DFFB(3), DIABLO(1) 4522355 49 38 49 15 26 5 6 7 5 0 0.149 1.000 1.000 75 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(11), BCAT2(1), COASY(3), DPYD(56), DPYS(22), ENPP1(11), ENPP3(14), ILVBL(4), PANK1(2), PANK2(3), PANK3(3), PANK4(6), PPCS(3), UPB1(6), VNN1(7) 5774266 152 81 138 43 110 10 4 17 11 0 6.21e-05 1.000 1.000 76 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(5), CD3D(5), CD3E(2), CD3G(1), GZMB(3), HLA-A(3), ICAM1(2), ITGAL(24), ITGB2(13), PRF1(11) 2909979 69 44 68 29 42 7 1 5 14 0 0.0461 1.000 1.000 77 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(16), ADORA1(6), ADORA2A(2), ADORA2B(1), ADORA3(12), ADRA1A(8), ADRA1B(3), ADRA2A(3), ADRA2B(9), ADRA2C(2), ADRB1(5), ADRB2(2), AGTR1(10), AGTR2(9), AVPR1A(4), AVPR1B(9), AVPR2(1), BDKRB1(5), BDKRB2(9), BRS3(5), C3AR1(4), C5AR1(9), CALCR(15), CALCRL(14), CCKAR(9), CCKBR(10), CGA(1), CHRM1(5), CHRM2(18), CHRM3(19), CHRM4(6), CHRM5(4), CNR1(9), CNR2(4), CRHR1(6), CRHR2(2), CTSG(4), CYSLTR1(4), CYSLTR2(2), DRD1(8), DRD2(15), DRD3(5), DRD4(1), DRD5(22), EDNRA(8), EDNRB(4), F2(9), F2R(6), F2RL1(15), F2RL2(6), F2RL3(3), FPR1(18), FSHB(4), FSHR(15), GABBR1(7), GABBR2(10), GABRA1(16), GABRA2(15), GABRA3(19), GABRA4(12), GABRA5(2), GABRA6(22), GABRB1(16), GABRB2(19), GABRB3(17), GABRD(5), GABRE(20), GABRG1(28), GABRG2(14), GABRG3(7), GABRP(12), GABRQ(7), GABRR1(7), GABRR2(1), GALR1(5), GALR3(2), GH1(3), GH2(10), GHR(25), GHRHR(4), GHSR(8), GIPR(2), GLP1R(11), GLP2R(14), GLRA1(11), GLRA2(5), GLRA3(12), GLRB(26), GNRHR(2), GPR156(10), GPR35(3), GPR50(17), GPR63(6), GPR83(13), GRIA1(39), GRIA2(34), GRIA3(23), GRIA4(23), GRID1(22), GRID2(51), GRIK1(22), GRIK2(20), GRIK3(28), GRIK4(11), GRIK5(10), GRIN1(7), GRIN2A(86), GRIN2B(53), GRIN2C(8), GRIN2D(6), GRIN3A(40), GRIN3B(4), GRM1(16), GRM2(7), GRM3(49), GRM4(19), GRM5(13), GRM6(24), GRM7(32), GRM8(43), GRPR(5), GZMA(11), HCRTR1(2), HCRTR2(26), HRH1(14), HRH2(3), HRH3(4), HRH4(5), HTR1A(8), HTR1B(1), HTR1D(3), HTR1E(5), HTR1F(7), HTR2A(8), HTR2B(2), HTR2C(10), HTR4(9), HTR5A(16), HTR6(1), HTR7(8), LEP(2), LEPR(22), LHCGR(24), LTB4R(1), LTB4R2(1), MAS1(3), MC2R(5), MC3R(7), MC4R(1), MC5R(7), MCHR1(3), MCHR2(14), MLNR(1), MTNR1A(8), MTNR1B(7), NMBR(6), NMUR1(6), NMUR2(14), NPBWR1(2), NPBWR2(10), NPFFR1(1), NPFFR2(11), NPY1R(25), NPY2R(12), NPY5R(22), NR3C1(7), NTSR1(6), NTSR2(3), OPRD1(2), OPRK1(21), OPRL1(5), OPRM1(5), OXTR(5), P2RX1(3), P2RX2(2), P2RX3(9), P2RX4(2), P2RX5(8), P2RX7(5), P2RY1(4), P2RY10(6), P2RY13(4), P2RY14(8), P2RY2(8), P2RY6(1), P2RY8(6), PARD3(15), PPYR1(12), PRL(1), PRLHR(1), PRLR(29), PRSS1(25), PRSS3(4), PTAFR(2), PTGDR(9), PTGER2(6), PTGER3(3), PTGER4(1), PTGFR(20), PTGIR(5), PTH2R(14), RXFP1(15), RXFP2(22), SCTR(7), SSTR1(10), SSTR2(5), SSTR3(11), SSTR4(3), SSTR5(3), TAAR1(2), TAAR2(9), TAAR5(3), TAAR6(11), TAAR8(7), TAAR9(3), TACR1(7), TACR2(7), TACR3(25), TBXA2R(4), THRA(2), THRB(14), TRHR(19), TRPV1(2), TSHB(6), TSHR(8), UTS2R(1), VIPR1(4), VIPR2(5) 73362745 2385 209 2212 1472 1692 196 78 221 196 2 6.84e-09 1.000 1.000 78 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 188 ACTB(7), ACTG1(5), ACTN1(5), ACTN2(21), ACTN3(7), ACTN4(5), AKT1(3), AKT2(8), AKT3(4), ARHGAP5(11), BCAR1(4), BCL2(2), BIRC2(5), BIRC3(7), CAPN2(6), CAV1(1), CCND1(1), CCND2(5), CCND3(2), CDC42(2), CHAD(3), COL11A1(58), COL11A2(36), COL1A1(41), COL1A2(39), COL2A1(29), COL3A1(64), COL4A1(57), COL4A2(30), COL4A4(91), COL4A6(32), COL5A1(63), COL5A2(41), COL5A3(67), COL6A1(8), COL6A2(21), COL6A3(57), COL6A6(53), COMP(7), CRK(2), CRKL(2), CTNNB1(11), DIAPH1(6), DOCK1(15), EGF(18), EGFR(22), ELK1(2), ERBB2(7), FARP2(5), FIGF(4), FLNA(15), FLNB(38), FLNC(56), FLT1(33), FN1(21), FYN(6), GRB2(2), GRLF1(11), GSK3B(2), HGF(23), HRAS(3), IBSP(7), IGF1(11), IGF1R(10), ITGA1(18), ITGA10(7), ITGA11(16), ITGA2(11), ITGA2B(10), ITGA3(7), ITGA4(36), ITGA5(20), ITGA6(8), ITGA7(23), ITGA8(36), ITGA9(13), ITGAV(9), ITGB1(4), ITGB3(11), ITGB4(20), ITGB5(6), ITGB6(11), ITGB7(6), ITGB8(17), JUN(1), KDR(42), LAMA1(37), LAMA2(56), LAMA3(56), LAMA4(11), LAMA5(27), LAMB1(9), LAMB2(11), LAMB3(23), LAMB4(37), LAMC1(10), LAMC2(20), LAMC3(6), MAP2K1(10), MAPK1(4), MAPK10(8), MAPK3(1), MAPK8(1), MAPK9(5), MET(19), MYL2(5), MYL5(1), MYL7(2), MYL9(2), MYLK(39), MYLK2(10), MYLPF(2), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PARVA(1), PARVB(3), PARVG(3), PDGFA(1), PDGFB(3), PDGFC(16), PDGFD(6), PDGFRA(27), PDGFRB(16), PDPK1(4), PGF(1), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PIP5K1C(8), PPP1CA(1), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PRKCA(10), PRKCG(13), PTK2(8), PXN(3), RAC2(1), RAF1(8), RAP1A(2), RAP1B(1), RAPGEF1(10), RELN(70), RHOA(1), ROCK1(5), ROCK2(12), SHC1(1), SHC2(7), SHC3(11), SHC4(2), SOS1(8), SOS2(11), SPP1(7), SRC(1), THBS1(27), THBS2(9), THBS3(10), THBS4(11), TLN1(12), TLN2(23), TNC(32), TNN(46), TNR(70), TNXB(128), VASP(3), VAV1(15), VAV2(3), VAV3(9), VCL(7), VEGFA(5), VEGFB(1), VTN(7), VWF(49), ZYX(6) 122750871 2909 209 2789 1268 2105 201 82 284 234 3 6.97e-08 1.000 1.000 79 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(7), ACTG1(5), CHAD(3), COL11A1(58), COL11A2(36), COL17A1(27), COL1A1(41), COL1A2(39), COL2A1(29), COL3A1(64), COL4A1(57), COL4A2(30), COL4A4(91), COL4A6(32), COL5A1(63), COL5A2(41), COL5A3(67), COL6A1(8), COL6A2(21), COL6A3(57), COL6A6(53), COMP(7), DES(8), DSC1(42), DSC2(36), DSC3(37), DSG1(56), DSG2(21), DSG3(60), DSG4(56), FN1(21), GJA1(7), GJA10(13), GJA3(1), GJA4(4), GJA5(7), GJA8(18), GJA9(3), GJB1(1), GJB2(3), GJB3(3), GJB4(6), GJB5(6), GJB6(6), GJB7(2), GJC1(6), GJC3(1), GJD2(5), IBSP(7), INA(4), ITGA6(8), ITGB4(20), KRT1(19), KRT10(14), KRT12(11), KRT13(11), KRT14(2), KRT15(10), KRT16(11), KRT17(8), KRT18(3), KRT2(17), KRT20(7), KRT23(8), KRT24(7), KRT25(10), KRT27(5), KRT28(10), KRT3(13), KRT31(8), KRT32(10), KRT33A(5), KRT33B(3), KRT34(10), KRT35(8), KRT36(16), KRT37(11), KRT38(8), KRT39(12), KRT4(17), KRT40(6), KRT5(15), KRT6A(16), KRT6B(8), KRT6C(13), KRT7(5), KRT71(15), KRT72(11), KRT73(15), KRT74(13), KRT75(14), KRT76(12), KRT77(13), KRT78(19), KRT79(8), KRT8(6), KRT81(3), KRT82(8), KRT83(14), KRT84(10), KRT85(7), KRT86(7), KRT9(19), LAMA1(37), LAMA2(56), LAMA3(56), LAMA4(11), LAMA5(27), LAMB1(9), LAMB2(11), LAMB3(23), LAMB4(37), LAMC1(10), LAMC2(20), LAMC3(6), LMNA(8), LMNB1(2), LMNB2(4), NES(21), PRPH(1), RELN(70), SPP1(7), THBS1(27), THBS2(9), THBS3(10), THBS4(11), TNC(32), TNN(46), TNR(70), TNXB(128), VIM(5), VTN(7), VWF(49) 83420384 2645 204 2523 1115 1992 194 62 206 190 1 3.07e-11 1.000 1.000 80 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(12), CD36(4), CD44(5), CD47(1), CHAD(3), COL11A1(58), COL11A2(36), COL1A1(41), COL1A2(39), COL2A1(29), COL3A1(64), COL4A1(57), COL4A2(30), COL4A4(91), COL4A6(32), COL5A1(63), COL5A2(41), COL5A3(67), COL6A1(8), COL6A2(21), COL6A3(57), COL6A6(53), DAG1(5), FN1(21), FNDC1(32), FNDC3A(9), FNDC4(5), FNDC5(3), GP5(4), GP6(5), GP9(6), HMMR(4), HSPG2(24), IBSP(7), ITGA1(18), ITGA10(7), ITGA11(16), ITGA2(11), ITGA2B(10), ITGA3(7), ITGA4(36), ITGA5(20), ITGA6(8), ITGA7(23), ITGA8(36), ITGA9(13), ITGAV(9), ITGB1(4), ITGB3(11), ITGB4(20), ITGB5(6), ITGB6(11), ITGB7(6), ITGB8(17), LAMA1(37), LAMA2(56), LAMA3(56), LAMA4(11), LAMA5(27), LAMB1(9), LAMB2(11), LAMB3(23), LAMB4(37), LAMC1(10), LAMC2(20), LAMC3(6), RELN(70), SDC1(3), SDC2(2), SDC3(6), SDC4(3), SPP1(7), SV2A(16), SV2B(29), SV2C(14), THBS1(27), THBS2(9), THBS3(10), THBS4(11), TNC(32), TNN(46), TNR(70), TNXB(128), VTN(7), VWF(49) 74870946 2068 202 1987 871 1552 121 61 170 163 1 0.000160 1.000 1.000 81 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 167 ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY7(10), ADCY8(45), ADCY9(9), ADORA2A(2), ADORA2B(1), ADRA1A(8), ADRA1B(3), ADRA1D(4), ADRB1(5), ADRB2(2), AGTR1(10), ATP2A1(9), ATP2A2(12), ATP2A3(14), ATP2B1(6), ATP2B2(24), ATP2B3(9), ATP2B4(15), AVPR1A(4), AVPR1B(9), BDKRB1(5), BDKRB2(9), BST1(1), CACNA1A(32), CACNA1B(26), CACNA1C(43), CACNA1D(29), CACNA1E(97), CACNA1F(20), CACNA1G(30), CACNA1H(23), CACNA1I(33), CACNA1S(46), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CAMK4(10), CCKAR(9), CCKBR(10), CD38(4), CHP(3), CHRM1(5), CHRM2(18), CHRM3(19), CHRM5(4), CHRNA7(3), CYSLTR1(4), CYSLTR2(2), DRD1(8), EDNRA(8), EDNRB(4), EGFR(22), ERBB2(7), ERBB3(5), ERBB4(47), F2R(6), GNA11(7), GNA14(5), GNA15(5), GNAL(2), GNAQ(4), GNAS(19), GRIN1(7), GRIN2A(86), GRIN2C(8), GRIN2D(6), GRM1(16), GRM5(13), GRPR(5), HRH1(14), HRH2(3), HTR2A(8), HTR2B(2), HTR2C(10), HTR4(9), HTR5A(16), HTR6(1), HTR7(8), ITPKB(6), ITPR1(29), ITPR2(17), ITPR3(6), LHCGR(24), LTB4R2(1), MYLK(39), MYLK2(10), NOS1(58), NOS3(16), NTSR1(6), OXTR(5), P2RX1(3), P2RX2(2), P2RX3(9), P2RX4(2), P2RX5(8), P2RX7(5), PDE1B(12), PDE1C(41), PDGFRA(27), PDGFRB(16), PHKA1(19), PHKA2(7), PHKB(7), PHKG1(1), PHKG2(2), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PLCD1(3), PLCD3(3), PLCD4(2), PLCE1(48), PLCG1(9), PLCG2(25), PLCZ1(20), PPID(1), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PRKACA(3), PRKACB(4), PRKACG(8), PRKCA(10), PRKCG(13), PRKX(3), PTAFR(2), PTGER3(3), PTGFR(20), PTK2B(10), RYR1(87), RYR2(84), RYR3(78), SLC25A6(2), SLC8A1(27), SLC8A2(9), SLC8A3(34), SPHK1(1), SPHK2(7), TACR1(7), TACR2(7), TACR3(25), TBXA2R(4), TNNC1(2), TNNC2(3), TRHR(19), TRPC1(5), VDAC1(1), VDAC2(1), VDAC3(1) 88453764 2231 201 2113 1474 1603 160 76 190 198 4 0.0380 1.000 1.000 82 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1(2), ACVR1B(3), ACVR2A(3), ACVR2B(3), AMHR2(15), BMP2(4), BMP7(2), BMPR1A(2), BMPR1B(3), BMPR2(5), CCL1(1), CCL11(1), CCL14(2), CCL15(3), CCL16(1), CCL18(1), CCL2(1), CCL20(2), CCL21(2), CCL22(1), CCL24(3), CCL25(1), CCL26(1), CCL27(2), CCL28(1), CCL7(4), CCL8(3), CCR1(9), CCR2(16), CCR3(10), CCR4(7), CCR5(7), CCR6(2), CCR7(3), CCR8(6), CCR9(5), CD27(3), CD40(4), CD40LG(2), CLCF1(1), CNTF(1), CNTFR(3), CSF1(10), CSF1R(12), CSF2(2), CSF2RA(17), CSF2RB(17), CSF3(4), CSF3R(6), CX3CL1(4), CX3CR1(13), CXCL10(3), CXCL11(1), CXCL12(2), CXCL13(1), CXCL14(1), CXCL3(1), CXCL5(2), CXCL6(1), CXCL9(2), CXCR3(4), CXCR4(3), CXCR6(4), EDA(2), EDA2R(3), EDAR(5), EGF(18), EGFR(22), EPO(5), EPOR(1), FAS(5), FASLG(14), FLT1(33), FLT3(31), FLT3LG(2), FLT4(23), GDF5(13), GH1(3), GH2(10), GHR(25), HGF(23), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(9), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(5), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IFNG(2), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(4), IL10(3), IL10RA(7), IL10RB(5), IL11(2), IL11RA(3), IL12A(3), IL12B(3), IL12RB1(15), IL12RB2(3), IL13(2), IL13RA1(3), IL15(3), IL15RA(6), IL17A(9), IL17B(3), IL17RA(4), IL17RB(2), IL18(2), IL18R1(17), IL18RAP(16), IL19(2), IL1A(4), IL1B(6), IL1R1(11), IL1R2(7), IL1RAP(4), IL2(4), IL20(4), IL20RA(9), IL21(6), IL21R(17), IL22(1), IL22RA1(11), IL22RA2(1), IL23A(2), IL23R(7), IL25(2), IL26(3), IL28A(1), IL28B(4), IL28RA(4), IL29(1), IL2RA(4), IL2RB(7), IL2RG(3), IL3(3), IL3RA(7), IL4(1), IL4R(13), IL5(4), IL5RA(12), IL6(2), IL6R(4), IL6ST(10), IL7(5), IL7R(27), IL8(1), IL9(1), IL9R(5), INHBA(16), INHBB(7), INHBC(11), INHBE(3), KDR(42), KIT(9), KITLG(8), LEP(2), LEPR(22), LIF(2), LIFR(33), LTA(2), LTB(2), MET(19), MPL(7), NGFR(7), OSM(5), OSMR(35), PDGFB(3), PDGFC(16), PDGFRA(27), PDGFRB(16), PLEKHO2(5), PPBP(5), PRL(1), PRLR(29), RELT(2), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(7), TNF(1), TNFRSF10A(5), TNFRSF10B(2), TNFRSF10C(4), TNFRSF10D(7), TNFRSF11A(5), TNFRSF11B(10), TNFRSF12A(1), TNFRSF13B(8), TNFRSF14(2), TNFRSF17(6), TNFRSF18(4), TNFRSF19(2), TNFRSF1A(3), TNFRSF1B(3), TNFRSF21(10), TNFRSF25(5), TNFRSF4(4), TNFRSF6B(2), TNFRSF8(17), TNFRSF9(4), TNFSF10(7), TNFSF11(4), TNFSF12(1), TNFSF13B(1), TNFSF14(7), TNFSF15(7), TNFSF18(7), TNFSF4(3), TNFSF8(3), TNFSF9(1), TPO(40), TSLP(1), VEGFA(5), VEGFB(1), XCL1(1), XCL2(2), XCR1(4) 58721906 1451 201 1396 796 1041 100 38 131 141 0 0.0374 1.000 1.000 83 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 199 ACTN1(5), ACTN2(21), ACTN3(7), ACTN4(5), APC(19), APC2(9), ARAF(4), ARHGEF1(1), ARHGEF12(11), ARHGEF4(4), ARHGEF6(10), ARHGEF7(3), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), ARPC5(1), BAIAP2(5), BCAR1(4), BDKRB1(5), BDKRB2(9), CD14(5), CDC42(2), CFL1(1), CHRM1(5), CHRM2(18), CHRM3(19), CHRM4(6), CHRM5(4), CRK(2), CRKL(2), CSK(1), CYFIP1(7), CYFIP2(23), DIAPH1(6), DIAPH2(7), DIAPH3(11), DOCK1(15), EGF(18), EGFR(22), EZR(1), F2(9), F2R(6), FGD1(3), FGD3(8), FGF1(1), FGF10(2), FGF11(2), FGF12(12), FGF13(6), FGF14(5), FGF17(2), FGF18(2), FGF19(3), FGF2(2), FGF21(4), FGF23(8), FGF3(5), FGF4(2), FGF5(5), FGF6(6), FGF7(7), FGF8(1), FGF9(4), FGFR1(11), FGFR2(31), FGFR3(9), FGFR4(9), FN1(21), GIT1(4), GNA12(3), GNA13(1), GRLF1(11), GSN(6), HRAS(3), IQGAP1(10), IQGAP2(22), IQGAP3(10), ITGA1(18), ITGA10(7), ITGA11(16), ITGA2(11), ITGA2B(10), ITGA3(7), ITGA4(36), ITGA5(20), ITGA6(8), ITGA7(23), ITGA8(36), ITGA9(13), ITGAD(24), ITGAE(16), ITGAL(24), ITGAM(21), ITGAV(9), ITGAX(18), ITGB1(4), ITGB2(13), ITGB3(11), ITGB4(20), ITGB5(6), ITGB6(11), ITGB7(6), ITGB8(17), KRAS(4), LIMK1(4), LIMK2(9), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), MOS(5), MRAS(1), MSN(1), MYH10(13), MYH14(17), MYH9(12), MYL2(5), MYL5(1), MYL7(2), MYL9(2), MYLK(39), MYLK2(10), MYLPF(2), NCKAP1(5), NCKAP1L(30), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PDGFA(1), PDGFB(3), PDGFRA(27), PDGFRB(16), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PIP4K2A(5), PIP4K2B(3), PIP4K2C(3), PIP5K1A(6), PIP5K1B(18), PIP5K1C(8), PPP1CA(1), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PPP1R12B(8), PTK2(8), PXN(3), RAC2(1), RAF1(8), RDX(1), RHOA(1), ROCK1(5), ROCK2(12), RRAS(1), SCIN(7), SLC9A1(3), SOS1(8), SOS2(11), SSH1(14), SSH2(7), SSH3(3), TIAM1(25), TIAM2(27), TMSL3(2), VAV1(15), VAV2(3), VAV3(9), VCL(7), WAS(7), WASF1(4), WASF2(4), WASL(5) 90938229 1615 200 1557 824 1083 109 57 209 153 4 0.00221 1.000 1.000 84 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 242 ACVR1B(3), ACVR1C(9), AKT1(3), AKT2(8), AKT3(4), ARRB1(3), ARRB2(6), ATF2(5), ATF4(7), BDNF(3), CACNA1A(32), CACNA1B(26), CACNA1C(43), CACNA1D(29), CACNA1E(97), CACNA1F(20), CACNA1G(30), CACNA1H(23), CACNA1I(33), CACNA1S(46), CACNA2D1(10), CACNA2D2(14), CACNA2D3(45), CACNA2D4(18), CACNB1(4), CACNB2(12), CACNB3(2), CACNB4(11), CACNG1(3), CACNG2(9), CACNG3(19), CACNG4(3), CACNG5(10), CACNG6(5), CACNG7(5), CACNG8(1), CASP3(2), CD14(5), CDC25B(4), CDC42(2), CHP(3), CHUK(2), CRK(2), CRKL(2), DAXX(9), DDIT3(2), DUSP10(6), DUSP14(2), DUSP16(4), DUSP2(1), DUSP3(1), DUSP4(1), DUSP5(2), DUSP6(1), DUSP7(2), DUSP8(3), DUSP9(3), ECSIT(2), EGF(18), EGFR(22), ELK1(2), ELK4(7), FAS(5), FASLG(14), FGF1(1), FGF10(2), FGF11(2), FGF12(12), FGF13(6), FGF14(5), FGF17(2), FGF18(2), FGF19(3), FGF2(2), FGF21(4), FGF23(8), FGF3(5), FGF4(2), FGF5(5), FGF6(6), FGF7(7), FGF8(1), FGF9(4), FGFR1(11), FGFR2(31), FGFR3(9), FGFR4(9), FLNA(15), FLNB(38), FLNC(56), FOS(2), GADD45B(2), GNA12(3), GRB2(2), HRAS(3), IKBKB(3), IL1A(4), IL1B(6), IL1R1(11), IL1R2(7), JUN(1), JUND(1), KRAS(4), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K5(3), MAP2K6(3), MAP2K7(4), MAP3K1(2), MAP3K10(8), MAP3K12(3), MAP3K13(10), MAP3K14(3), MAP3K2(6), MAP3K3(6), MAP3K4(16), MAP3K5(16), MAP3K6(6), MAP3K7(1), MAP4K1(9), MAP4K2(6), MAP4K3(8), MAP4K4(7), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK7(4), MAPK8(1), MAPK8IP1(4), MAPK8IP2(7), MAPK8IP3(8), MAPK9(5), MAPKAPK2(5), MAPKAPK3(3), MAPKAPK5(1), MAPT(10), MEF2C(2), MKNK1(5), MKNK2(2), MOS(5), MRAS(1), MYC(5), NF1(40), NFATC2(9), NFATC4(13), NFKB1(7), NFKB2(4), NLK(5), NR4A1(3), NTF3(6), NTRK1(15), NTRK2(9), PAK1(4), PAK2(8), PDGFA(1), PDGFB(3), PDGFRA(27), PDGFRB(16), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PPM1A(3), PPM1B(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PPP5C(2), PRKACA(3), PRKACB(4), PRKACG(8), PRKCA(10), PRKCG(13), PRKX(3), PTPN5(11), PTPN7(2), PTPRR(24), RAC2(1), RAF1(8), RAP1A(2), RAP1B(1), RAPGEF2(9), RASA1(4), RASA2(14), RASGRF1(20), RASGRF2(19), RASGRP1(7), RASGRP2(6), RASGRP3(13), RASGRP4(10), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KA4(4), RPS6KA5(4), RPS6KA6(15), RRAS(1), SOS1(8), SOS2(11), SRF(2), STK4(3), STMN1(3), TAOK1(11), TAOK2(24), TAOK3(3), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(7), TNF(1), TNFRSF1A(3), TRAF2(2), TRAF6(4), ZAK(6) 93126872 1841 199 1769 1090 1221 173 60 198 184 5 0.494 1.000 1.000 85 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 125 ABL1(12), ABLIM1(12), ABLIM2(6), ABLIM3(7), ARHGEF12(11), CDC42(2), CDK5(4), CFL1(1), CHP(3), CXCL12(2), CXCR4(3), DCC(76), DPYSL2(4), DPYSL5(11), EFNA2(1), EFNA4(2), EFNA5(3), EFNB1(1), EFNB3(2), EPHA1(15), EPHA2(14), EPHA3(25), EPHA4(17), EPHA5(7), EPHA6(60), EPHA7(42), EPHA8(16), EPHB1(25), EPHB2(29), EPHB3(14), EPHB4(10), EPHB6(22), FES(5), FYN(6), GNAI1(1), GNAI2(5), GNAI3(2), GSK3B(2), HRAS(3), ITGB1(4), KRAS(4), L1CAM(8), LIMK1(4), LIMK2(9), LRRC4C(39), MAPK1(4), MAPK3(1), MET(19), NCK1(1), NCK2(4), NFAT5(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NGEF(13), NRP1(18), NTN4(16), NTNG1(14), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PLXNA1(14), PLXNA2(9), PLXNA3(10), PLXNB1(20), PLXNB2(16), PLXNB3(6), PLXNC1(16), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PTK2(8), RAC2(1), RASA1(4), RGS3(12), RHOA(1), RHOD(2), RND1(5), ROBO1(22), ROBO2(33), ROBO3(14), ROCK1(5), ROCK2(12), SEMA3A(11), SEMA3B(2), SEMA3C(3), SEMA3D(11), SEMA3E(22), SEMA3F(10), SEMA3G(13), SEMA4A(8), SEMA4B(4), SEMA4C(7), SEMA4D(9), SEMA4F(6), SEMA4G(8), SEMA5A(18), SEMA5B(16), SEMA6A(8), SEMA6B(7), SEMA6C(8), SEMA6D(4), SEMA7A(3), SLIT1(16), SLIT2(56), SLIT3(45), SRGAP1(6), SRGAP2(7), SRGAP3(32), UNC5A(8), UNC5B(9), UNC5C(16), UNC5D(23) 64785387 1394 194 1326 727 971 108 38 156 119 2 0.0108 1.000 1.000 86 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 151 AKT1(3), AKT2(8), AKT3(4), CBL(8), CBLB(16), CBLC(14), CCND1(1), CCND2(5), CCND3(2), CISH(3), CLCF1(1), CNTF(1), CNTFR(3), CREBBP(20), CSF2(2), CSF2RA(17), CSF2RB(17), CSF3(4), CSF3R(6), EP300(14), EPO(5), EPOR(1), GH1(3), GH2(10), GHR(25), GRB2(2), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(9), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(5), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IFNG(2), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(4), IL10(3), IL10RA(7), IL10RB(5), IL11(2), IL11RA(3), IL12A(3), IL12B(3), IL12RB1(15), IL12RB2(3), IL13(2), IL13RA1(3), IL13RA2(3), IL15(3), IL15RA(6), IL19(2), IL2(4), IL20(4), IL20RA(9), IL21(6), IL21R(17), IL22(1), IL22RA1(11), IL22RA2(1), IL23A(2), IL23R(7), IL26(3), IL28A(1), IL28B(4), IL28RA(4), IL29(1), IL2RA(4), IL2RB(7), IL2RG(3), IL3(3), IL3RA(7), IL4(1), IL4R(13), IL5(4), IL5RA(12), IL6(2), IL6R(4), IL6ST(10), IL7(5), IL7R(27), IL9(1), IL9R(5), IRF9(1), JAK1(6), JAK2(9), JAK3(6), LEP(2), LEPR(22), LIF(2), LIFR(33), MPL(7), MYC(5), OSM(5), OSMR(35), PIAS1(5), PIAS2(5), PIAS3(5), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PIM1(1), PRL(1), PRLR(29), PTPN11(9), PTPN6(3), SOCS2(2), SOCS3(2), SOCS4(3), SOCS5(5), SOCS7(4), SOS1(8), SOS2(11), SPRED1(5), SPRED2(2), SPRY1(7), SPRY2(4), SPRY3(11), SPRY4(1), STAM(4), STAM2(1), STAT1(4), STAT2(8), STAT3(10), STAT4(22), STAT5A(2), STAT5B(4), STAT6(7), TPO(40), TSLP(1), TYK2(7) 48583509 963 191 929 451 638 75 37 117 95 1 0.0199 1.000 1.000 87 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADCY9(9), ADRA1A(8), ADRA1B(3), ADRA1D(4), ADRB1(5), ADRB2(2), ANXA6(6), ARRB1(3), ARRB2(6), ATP1A4(12), ATP1B1(1), ATP1B3(1), ATP2A2(12), ATP2A3(14), ATP2B1(6), ATP2B2(24), ATP2B3(9), CACNA1A(32), CACNA1B(26), CACNA1C(43), CACNA1D(29), CACNA1E(97), CACNA1S(46), CACNB1(4), CACNB3(2), CALM1(1), CALM2(1), CALR(1), CAMK1(4), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CAMK4(10), CASQ1(8), CASQ2(4), CHRM1(5), CHRM2(18), CHRM3(19), CHRM4(6), CHRM5(4), GJA1(7), GJA4(4), GJA5(7), GJB1(1), GJB2(3), GJB3(3), GJB4(6), GJB5(6), GJB6(6), GNA11(7), GNAI2(5), GNAI3(2), GNAO1(2), GNAQ(4), GNAZ(6), GNB3(7), GNB4(3), GNB5(2), GNG2(3), GNG4(2), GNG7(2), GRK4(8), GRK5(4), GRK6(3), ITPR1(29), ITPR2(17), ITPR3(6), KCNB1(31), KCNJ3(18), KCNJ5(12), MIB1(5), NME7(4), PKIA(3), PKIB(1), PKIG(1), PLCB3(4), PRKACA(3), PRKACB(4), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), PRKCD(4), PRKCE(6), PRKCG(13), PRKCH(10), PRKCQ(16), PRKCZ(5), PRKD1(3), RGS1(3), RGS11(2), RGS14(3), RGS16(2), RGS18(8), RGS20(2), RGS3(12), RGS4(2), RGS5(2), RGS6(14), RGS7(36), RGS9(10), RYR1(87), RYR2(84), RYR3(78), SFN(1), SLC8A1(27), SLC8A3(34), USP5(4), YWHAB(1), YWHAQ(3) 62094424 1353 190 1283 967 943 126 54 114 113 3 0.822 1.000 1.000 88 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(4), ACTA2(4), ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADCY9(9), ARRB1(3), ARRB2(6), ATF1(4), ATF2(5), ATF4(7), ATF5(7), ATP2A2(12), ATP2A3(14), CACNB3(2), CALCA(2), CALM1(1), CALM2(1), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CNN1(5), CNN2(2), CORIN(26), CREB3(1), CRH(3), CRHR1(6), DGKZ(7), ETS2(8), FOS(2), GABPA(1), GABPB2(8), GBA2(2), GJA1(7), GNAQ(4), GNB3(7), GNB4(3), GNB5(2), GNG2(3), GNG4(2), GNG7(2), GRK4(8), GRK5(4), GRK6(3), GSTO1(2), GUCA2A(1), GUCA2B(1), GUCY1A3(29), IGFBP1(3), IGFBP2(2), IGFBP3(2), IGFBP6(2), IL1B(6), IL6(2), ITPR1(29), ITPR2(17), ITPR3(6), JUN(1), MIB1(5), MYL2(5), MYL4(5), MYLK2(10), NFKB1(7), NOS1(58), NOS3(16), OXTR(5), PDE4B(7), PDE4D(7), PKIA(3), PKIB(1), PKIG(1), PLCB3(4), PLCD1(3), PLCG1(9), PLCG2(25), PRKACA(3), PRKACB(4), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), PRKCD(4), PRKCE(6), PRKCH(10), PRKCQ(16), PRKCZ(5), PRKD1(3), RAMP1(1), RAMP2(1), RAMP3(2), RGS1(3), RGS11(2), RGS14(3), RGS16(2), RGS18(8), RGS20(2), RGS3(12), RGS4(2), RGS5(2), RGS6(14), RGS7(36), RGS9(10), RLN1(3), RYR1(87), RYR2(84), RYR3(78), SFN(1), SLC8A1(27), SP1(5), TNXB(128), USP5(4), YWHAB(1), YWHAQ(3) 58018431 1198 189 1139 717 851 101 42 111 90 3 0.0626 1.000 1.000 89 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(4), ACTA2(4), ACTN2(21), ACTN3(7), ACTN4(5), DES(8), DMD(31), FAM48A(1), MYBPC1(19), MYBPC2(17), MYBPC3(15), MYH3(21), MYH6(32), MYH7(43), MYH8(51), MYL1(12), MYL2(5), MYL3(2), MYL4(5), MYL9(2), MYOM1(23), NEB(107), TCAP(1), TNNC2(3), TNNI1(1), TNNI2(2), TNNI3(2), TNNT1(3), TNNT2(4), TNNT3(3), TPM1(3), TPM2(3), TPM3(2), TPM4(2), TTN(1045), VIM(5) 44331174 1514 189 1412 652 1127 106 51 137 82 11 6.65e-07 1.000 1.000 90 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 129 ACTB(7), ACTG1(5), ACTN1(5), ACTN2(21), ACTN3(7), ACTN4(5), AKT1(3), AKT2(8), AKT3(4), AMOTL1(2), ASH1L(26), CASK(4), CDC42(2), CDK4(5), CGN(8), CLDN1(5), CLDN10(5), CLDN11(4), CLDN14(5), CLDN16(7), CLDN17(5), CLDN18(7), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(1), CLDN4(10), CLDN6(8), CLDN7(1), CLDN8(3), CLDN9(1), CRB3(1), CSDA(3), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(23), CTNNA3(28), CTNNB1(11), CTTN(2), EPB41(8), EPB41L1(10), EPB41L2(18), EPB41L3(6), EXOC3(3), EXOC4(9), F11R(5), GNAI1(1), GNAI2(5), GNAI3(2), HCLS1(9), HRAS(3), IGSF5(10), INADL(39), JAM2(10), JAM3(2), KRAS(4), LLGL1(4), LLGL2(12), MAGI1(26), MAGI2(22), MAGI3(12), MLLT4(13), MPDZ(12), MPP5(1), MRAS(1), MYH1(85), MYH10(13), MYH11(26), MYH13(36), MYH14(17), MYH15(53), MYH2(77), MYH3(21), MYH4(80), MYH6(32), MYH7(43), MYH7B(25), MYH8(51), MYH9(12), MYL2(5), MYL5(1), MYL7(2), MYL9(2), MYLPF(2), OCLN(4), PARD3(15), PARD6A(1), PARD6B(1), PARD6G(3), PPM1J(1), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(6), PPP2R3A(7), PPP2R3B(4), PPP2R4(2), PRKCA(10), PRKCD(4), PRKCE(6), PRKCG(13), PRKCH(10), PRKCI(8), PRKCQ(16), PRKCZ(5), RAB3B(1), RHOA(1), RRAS(1), SPTAN1(7), SRC(1), SYMPK(5), TJAP1(3), TJP1(11), TJP2(8), TJP3(18), VAPA(1), YES1(5), ZAK(6) 64136084 1288 188 1226 816 893 114 42 130 106 3 0.616 1.000 1.000 91 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(19), APC2(9), AXIN1(10), AXIN2(3), BTRC(4), CACYBP(2), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CCND1(1), CCND2(5), CCND3(2), CER1(12), CHD8(21), CHP(3), CREBBP(20), CSNK1A1(2), CSNK1A1L(5), CSNK1E(4), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), CTBP2(1), CTNNB1(11), CTNNBIP1(1), CUL1(5), CXXC4(1), DAAM1(5), DAAM2(5), DKK1(2), DKK2(14), DKK4(3), DVL2(3), DVL3(7), EP300(14), FBXW11(5), FZD1(4), FZD10(2), FZD2(5), FZD4(1), FZD5(2), FZD6(2), FZD7(4), FZD8(4), FZD9(1), GSK3B(2), JUN(1), LEF1(3), LRP5(18), LRP6(21), MAP3K7(1), MAPK10(8), MAPK8(1), MAPK9(5), MMP7(4), MYC(5), NFAT5(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NKD1(8), NKD2(5), NLK(5), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PORCN(4), PPARD(3), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(6), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PRICKLE1(9), PRICKLE2(5), PRKACA(3), PRKACB(4), PRKACG(8), PRKCA(10), PRKCG(13), PRKX(3), PSEN1(1), RAC2(1), RHOA(1), ROCK1(5), ROCK2(12), RUVBL1(1), SENP2(11), SFRP1(2), SFRP2(9), SFRP4(6), SMAD2(3), SMAD3(2), SMAD4(2), SOX17(6), TBL1X(5), TBL1XR1(1), TBL1Y(7), TCF7(1), TCF7L1(3), TCF7L2(7), VANGL1(2), VANGL2(8), WIF1(7), WNT1(2), WNT10A(7), WNT10B(5), WNT11(4), WNT16(1), WNT2(7), WNT2B(4), WNT3(5), WNT3A(6), WNT4(2), WNT5A(5), WNT5B(5), WNT6(2), WNT7A(13), WNT7B(6), WNT8A(7), WNT8B(7), WNT9A(3), WNT9B(3) 53190280 814 184 785 404 520 69 35 111 78 1 0.114 1.000 1.000 92 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(6), ADORA2A(2), ADORA2B(1), ADORA3(12), ADRA1A(8), ADRA1B(3), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(2), AGTR1(10), AGTR2(9), AVPR1A(4), AVPR1B(9), AVPR2(1), BDKRB1(5), BDKRB2(9), BRS3(5), C3AR1(4), CCBP2(8), CCKAR(9), CCKBR(10), CCR1(9), CCR10(2), CCR2(16), CCR3(10), CCR4(7), CCR5(7), CCR6(2), CCR7(3), CCR8(6), CCR9(5), CCRL2(5), CHML(4), CHRM1(5), CHRM2(18), CHRM3(19), CHRM4(6), CHRM5(4), CMKLR1(12), CNR1(9), CNR2(4), CX3CR1(13), CXCR3(4), CXCR4(3), DRD1(8), DRD2(15), DRD3(5), DRD4(1), DRD5(22), EDNRA(8), EDNRB(4), F2R(6), F2RL1(15), F2RL2(6), F2RL3(3), FPR1(18), FSHR(15), GALR1(5), GALR3(2), GALT(2), GHSR(8), GNB2L1(3), GPR17(1), GPR173(1), GPR174(12), GPR27(2), GPR3(2), GPR35(3), GPR37(9), GPR37L1(6), GPR4(4), GPR50(17), GPR6(6), GPR63(6), GPR77(5), GPR83(13), GPR85(5), GPR87(4), GRPR(5), HCRTR1(2), HCRTR2(26), HRH1(14), HRH2(3), HRH3(4), HTR1A(8), HTR1B(1), HTR1D(3), HTR1E(5), HTR1F(7), HTR2A(8), HTR2B(2), HTR2C(10), HTR4(9), HTR5A(16), HTR6(1), HTR7(8), LHCGR(24), LTB4R(1), MAS1(3), MC3R(7), MC4R(1), MC5R(7), MLNR(1), MTNR1A(8), MTNR1B(7), NMBR(6), NMUR1(6), NMUR2(14), NPY1R(25), NPY2R(12), NPY5R(22), NTSR1(6), NTSR2(3), OPN1SW(2), OPN3(3), OPRD1(2), OPRK1(21), OPRL1(5), OPRM1(5), OR10A5(7), OR11A1(6), OR12D3(5), OR1C1(9), OR1F1(5), OR1Q1(7), OR2H1(7), OR5V1(9), OR7A5(2), OR7C1(2), OR8B8(10), OXTR(5), P2RY1(4), P2RY10(6), P2RY12(3), P2RY13(4), P2RY14(8), P2RY2(8), P2RY6(1), PPYR1(12), PTAFR(2), PTGDR(9), PTGER2(6), PTGER4(1), PTGFR(20), PTGIR(5), RGR(5), RHO(2), RRH(1), SSTR1(10), SSTR2(5), SSTR3(11), SSTR4(3), SUCNR1(9), TBXA2R(4), TRHR(19) 40407007 1101 183 1042 821 750 110 36 128 77 0 0.00200 1.000 1.000 93 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 129 ALCAM(5), CADM1(3), CADM3(17), CD22(22), CD226(6), CD274(1), CD276(6), CD28(1), CD34(4), CD4(6), CD40(4), CD40LG(2), CD58(1), CD6(7), CD80(4), CD86(19), CD8A(2), CD8B(7), CD99(1), CDH1(5), CDH15(9), CDH2(12), CDH4(28), CDH5(9), CLDN1(5), CLDN10(5), CLDN11(4), CLDN14(5), CLDN16(7), CLDN17(5), CLDN18(7), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(1), CLDN4(10), CLDN6(8), CLDN7(1), CLDN8(3), CLDN9(1), CNTN1(22), CNTN2(14), CNTNAP1(11), CNTNAP2(75), CTLA4(2), ESAM(3), F11R(5), GLG1(5), HLA-A(3), HLA-B(5), HLA-C(1), HLA-DMA(4), HLA-DMB(7), HLA-DOA(4), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(7), HLA-DQB1(5), HLA-DRA(11), HLA-DRB1(3), HLA-DRB5(1), HLA-E(1), HLA-F(6), HLA-G(3), ICAM1(2), ICAM2(4), ICAM3(2), ICOS(3), ICOSLG(2), ITGA4(36), ITGA6(8), ITGA8(36), ITGA9(13), ITGAL(24), ITGAM(21), ITGAV(9), ITGB1(4), ITGB2(13), ITGB7(6), ITGB8(17), JAM2(10), JAM3(2), L1CAM(8), MADCAM1(1), MAG(11), MPZ(4), MPZL1(1), NCAM1(10), NCAM2(8), NEGR1(6), NEO1(12), NFASC(39), NLGN1(10), NLGN2(5), NLGN3(6), NRCAM(8), NRXN1(44), NRXN2(15), NRXN3(27), OCLN(4), PDCD1(3), PDCD1LG2(3), PTPRC(30), PTPRF(27), PTPRM(7), PVR(3), PVRL1(4), PVRL2(5), PVRL3(5), SDC1(3), SDC2(2), SDC3(6), SDC4(3), SELE(34), SELL(8), SELP(30), SELPLG(8), SIGLEC1(24), SPN(5), VCAM1(16), VCAN(34) 48587132 1154 182 1106 550 809 87 42 126 90 0 8.50e-05 1.000 1.000 94 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 141 ADA(2), ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADCY9(9), ADK(4), ADSL(6), ADSS(2), ADSSL1(8), AK1(1), AK2(3), AK5(6), AK7(22), ALLC(7), AMPD1(28), AMPD2(5), AMPD3(22), APRT(3), ATIC(5), CANT1(9), DGUOK(4), ENPP1(11), ENPP3(14), ENTPD1(10), ENTPD2(4), ENTPD3(6), ENTPD4(4), ENTPD5(1), ENTPD6(4), ENTPD8(2), FHIT(2), GART(9), GDA(12), GMPR2(1), GMPS(4), GUCY1A2(18), GUCY1A3(29), GUCY1B3(7), GUCY2C(32), GUCY2D(8), GUCY2F(15), GUK1(2), IMPDH1(2), IMPDH2(1), NME6(2), NME7(4), NPR1(16), NPR2(14), NT5C1A(3), NT5C1B(22), NT5C2(3), NT5C3(2), NT5E(4), NT5M(2), NUDT5(2), NUDT9(2), PAICS(1), PAPSS1(3), PAPSS2(5), PDE10A(12), PDE11A(17), PDE1C(41), PDE2A(13), PDE3B(6), PDE4A(9), PDE4B(7), PDE4C(16), PDE4D(7), PDE5A(8), PDE6D(2), PDE6G(2), PDE7A(1), PDE7B(16), PDE8A(2), PDE8B(21), PDE9A(9), PFAS(8), PKLR(11), PKM2(5), PNPT1(1), POLA1(2), POLA2(8), POLD1(6), POLD2(2), POLD3(4), POLE(15), POLE2(3), POLR1A(11), POLR1B(8), POLR1C(1), POLR2A(11), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(4), POLR3B(15), POLR3G(1), POLR3GL(1), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(14), PRPS1(2), PRPS1L1(13), PRPS2(3), PRUNE(1), RRM1(3), RRM2(2), RRM2B(2), XDH(50) 54200655 968 178 933 496 663 78 48 97 82 0 0.00799 1.000 1.000 95 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 65 A2M(22), BDKRB1(5), BDKRB2(9), C1QA(4), C1QB(3), C1QC(7), C1R(13), C1S(15), C2(14), C3(46), C3AR1(4), C4BPA(16), C4BPB(6), C5(14), C5AR1(9), C6(56), C7(43), C8B(43), C8G(1), C9(19), CD55(4), CD59(1), CFB(32), CFH(43), CFI(13), CPB2(1), CR1(53), CR2(32), F10(8), F11(12), F12(1), F13A1(26), F13B(23), F2(9), F2R(6), F5(30), F7(7), F8(42), F9(12), FGA(38), FGB(10), FGG(7), KLKB1(23), KNG1(11), MASP1(8), MASP2(9), MBL2(12), PLAT(3), PLAU(3), PLAUR(2), PLG(30), PROC(8), PROS1(13), SERPINA1(7), SERPINA5(9), SERPINC1(7), SERPIND1(4), SERPINE1(5), SERPINF2(6), SERPING1(12), TFPI(8), THBD(3), VWF(49) 29734032 991 178 929 429 697 76 42 98 76 2 0.000630 1.000 1.000 96 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(21), ACACB(17), AKT1(3), AKT2(8), AKT3(4), ARAF(4), CALM1(1), CALM2(1), CALML3(6), CBL(8), CBLB(16), CBLC(14), CRK(2), CRKL(2), EIF4EBP1(1), ELK1(2), EXOC7(8), FASN(17), FBP1(2), FBP2(2), FLOT1(2), FOXO1(6), G6PC(5), G6PC2(4), GCK(17), GRB2(2), GSK3B(2), GYS1(3), GYS2(20), HRAS(3), IKBKB(3), INPP5D(31), INSR(20), IRS1(5), IRS2(2), IRS4(12), KRAS(4), LIPE(8), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK10(8), MAPK3(1), MAPK8(1), MAPK9(5), MKNK1(5), MKNK2(2), PCK1(23), PCK2(4), PDE3A(24), PDE3B(6), PDPK1(4), PFKL(4), PFKM(1), PHKA1(19), PHKA2(7), PHKB(7), PHKG1(1), PHKG2(2), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PKLR(11), PKM2(5), PPARGC1A(20), PPP1CA(1), PPP1CB(5), PPP1CC(2), PPP1R3A(55), PPP1R3B(6), PPP1R3C(3), PPP1R3D(3), PRKAA1(1), PRKAA2(24), PRKAB1(2), PRKAB2(2), PRKACA(3), PRKACB(4), PRKACG(8), PRKAG1(2), PRKAG2(7), PRKAG3(10), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCI(8), PRKCZ(5), PRKX(3), PTPN1(4), PTPRF(27), PYGB(2), PYGL(7), PYGM(10), RAF1(8), RAPGEF1(10), RHEB(1), RHOQ(1), RPS6(1), RPS6KB1(2), RPS6KB2(3), SH2B2(4), SHC1(1), SHC2(7), SHC3(11), SHC4(2), SLC2A4(8), SOCS2(2), SOCS3(2), SOCS4(3), SORBS1(13), SOS1(8), SOS2(11), SREBF1(5), TRIP10(4), TSC1(5), TSC2(11) 52717617 885 177 848 407 594 63 37 111 78 2 0.00119 1.000 1.000 97 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 90 ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADCY9(9), ADRB1(5), CSNK1D(1), DRD1(8), DRD2(15), EGF(18), EGFR(22), GJA1(7), GJD2(5), GNA11(7), GNAI1(1), GNAI2(5), GNAI3(2), GNAQ(4), GNAS(19), GRB2(2), GRM1(16), GRM5(13), GUCY1A2(18), GUCY1A3(29), GUCY1B3(7), GUCY2C(32), GUCY2D(8), GUCY2F(15), HRAS(3), HTR2A(8), HTR2B(2), HTR2C(10), ITPR1(29), ITPR2(17), ITPR3(6), KRAS(4), MAP2K1(10), MAP2K2(3), MAP2K5(3), MAP3K2(6), MAPK1(4), MAPK3(1), MAPK7(4), NPR1(16), NPR2(14), PDGFA(1), PDGFB(3), PDGFC(16), PDGFD(6), PDGFRA(27), PDGFRB(16), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PRKACA(3), PRKACB(4), PRKACG(8), PRKCA(10), PRKCG(13), PRKG1(12), PRKG2(13), PRKX(3), RAF1(8), SOS1(8), SOS2(11), SRC(1), TJP1(11), TUBA1A(2), TUBA1B(4), TUBA1C(2), TUBA3C(21), TUBA3D(11), TUBA3E(3), TUBA4A(6), TUBA8(3), TUBAL3(11), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(5), TUBB4(3), TUBB4Q(9), TUBB6(10) 43490424 926 176 866 539 642 71 39 97 76 1 0.0767 1.000 1.000 98 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(5), ACTN2(21), ACTN3(7), ACTN4(5), ARHGAP5(11), BCAR1(4), CD99(1), CDC42(2), CDH5(9), CLDN1(5), CLDN10(5), CLDN11(4), CLDN14(5), CLDN16(7), CLDN17(5), CLDN18(7), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(1), CLDN4(10), CLDN6(8), CLDN7(1), CLDN8(3), CLDN9(1), CTNNA1(2), CTNNA2(23), CTNNA3(28), CTNNB1(11), CTNND1(9), CXCL12(2), CXCR4(3), CYBA(1), CYBB(7), ESAM(3), EZR(1), F11R(5), GNAI1(1), GNAI2(5), GNAI3(2), GRLF1(11), ICAM1(2), ITGA4(36), ITGAL(24), ITGAM(21), ITGB1(4), ITGB2(13), ITK(20), JAM2(10), JAM3(2), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MLLT4(13), MMP2(7), MMP9(7), MSN(1), MYL2(5), MYL5(1), MYL7(2), MYL9(2), MYLPF(2), NCF1(1), NCF2(7), NCF4(4), NOX1(11), NOX3(6), OCLN(4), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PLCG1(9), PLCG2(25), PRKCA(10), PRKCG(13), PTK2(8), PTK2B(10), PTPN11(9), PXN(3), RAC2(1), RAP1A(2), RAP1B(1), RAPGEF3(12), RAPGEF4(12), RASSF5(5), RHOA(1), RHOH(5), ROCK1(5), ROCK2(12), SIPA1(8), THY1(1), TXK(9), VASP(3), VAV1(15), VAV2(3), VAV3(9), VCAM1(16), VCL(7) 41100380 765 173 730 381 510 53 25 102 72 3 0.00720 1.000 1.000 99 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(17), AMY2A(5), AMY2B(10), ASCC3(10), ATP13A2(9), DDX18(4), DDX19A(1), DDX23(5), DDX4(11), DDX41(6), DDX47(1), DDX50(4), DDX51(5), DDX52(3), DDX54(2), DDX55(3), DDX56(3), DHX58(4), ENPP1(11), ENPP3(14), ENTPD7(2), EP400(22), ERCC2(2), ERCC3(4), G6PC(5), G6PC2(4), GAA(7), GANC(5), GBA(3), GBA3(14), GBE1(8), GCK(17), GPI(3), GUSB(3), GYS1(3), GYS2(20), HK1(3), HK2(12), HK3(13), IFIH1(13), MGAM(133), MOV10L1(26), NUDT5(2), NUDT8(1), PGM1(4), PGM3(1), PYGB(2), PYGL(7), PYGM(10), RAD54B(6), RUVBL2(4), SETX(17), SI(71), SKIV2L2(4), SMARCA2(11), SMARCA5(5), TREH(3), UGDH(1), UGP2(1), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(6), UGT1A9(10), UGT2A1(18), UGT2A3(24), UGT2B10(36), UGT2B11(19), UGT2B15(25), UGT2B28(24), UGT2B4(31), UGT2B7(17), UXS1(4) 41015142 877 172 820 384 603 73 36 82 82 1 0.000300 1.000 1.000 100 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 82 ANPEP(17), CD14(5), CD19(7), CD1A(11), CD1B(12), CD1C(23), CD1D(8), CD1E(19), CD22(22), CD33(17), CD34(4), CD36(4), CD37(3), CD38(4), CD3D(5), CD3E(2), CD3G(1), CD4(6), CD44(5), CD5(6), CD55(4), CD59(1), CD8A(2), CD8B(7), CR1(53), CR2(32), CSF1(10), CSF1R(12), CSF2(2), CSF2RA(17), CSF3(4), CSF3R(6), DNTT(9), EPO(5), EPOR(1), FCER2(3), FCGR1A(6), FLT3(31), FLT3LG(2), GP5(4), GP9(6), GYPA(7), HLA-DRA(11), HLA-DRB1(3), HLA-DRB5(1), IL11(2), IL11RA(3), IL1A(4), IL1B(6), IL1R1(11), IL1R2(7), IL2RA(4), IL3(3), IL3RA(7), IL4(1), IL4R(13), IL5(4), IL5RA(12), IL6(2), IL6R(4), IL7(5), IL7R(27), IL9R(5), ITGA1(18), ITGA2(11), ITGA2B(10), ITGA3(7), ITGA4(36), ITGA5(20), ITGA6(8), ITGAM(21), ITGB3(11), KIT(9), KITLG(8), MME(19), MS4A1(7), TFRC(4), THPO(7), TNF(1), TPO(40) 26892554 777 171 735 369 565 42 28 58 84 0 0.00367 1.000 1.000 101 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 72 ARAF(4), C7orf16(1), CACNA1A(32), CRH(3), CRHR1(6), GNA11(7), GNA12(3), GNA13(1), GNAI1(1), GNAI2(5), GNAI3(2), GNAO1(2), GNAQ(4), GNAS(19), GNAZ(6), GRIA1(39), GRIA2(34), GRIA3(23), GRID2(51), GRM1(16), GRM5(13), GUCY1A2(18), GUCY1A3(29), GUCY1B3(7), GUCY2C(32), GUCY2D(8), GUCY2F(15), HRAS(3), IGF1(11), IGF1R(10), ITPR1(29), ITPR2(17), ITPR3(6), KRAS(4), LYN(6), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), NOS1(58), NOS3(16), NPR1(16), NPR2(14), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(6), PRKCA(10), PRKCG(13), PRKG1(12), PRKG2(13), RAF1(8), RYR1(87) 35835626 941 170 869 544 677 63 28 92 80 1 0.0453 1.000 1.000 102 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 68 ADH1A(14), ADH1B(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), AKR1C1(2), AKR1C2(4), AKR1C3(9), AKR1C4(9), ALDH1A3(2), ALDH3A1(5), ALDH3B1(2), ALDH3B2(7), CYP1A1(10), CYP1A2(10), CYP1B1(2), CYP2B6(16), CYP2C18(26), CYP2C19(35), CYP2C8(30), CYP2C9(35), CYP2E1(13), CYP2F1(11), CYP2S1(9), CYP3A4(19), CYP3A43(15), CYP3A5(10), CYP3A7(18), DHDH(5), EPHX1(2), GSTA1(5), GSTA2(2), GSTA3(1), GSTA5(3), GSTK1(2), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTP1(2), GSTT1(1), MGST1(2), MGST2(2), MGST3(1), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(6), UGT1A9(10), UGT2A1(18), UGT2A3(24), UGT2B10(36), UGT2B11(19), UGT2B15(25), UGT2B28(24), UGT2B4(31), UGT2B7(17) 18844238 700 169 642 299 517 47 37 43 55 1 1.92e-08 1.000 1.000 103 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 108 ABL1(12), ANAPC1(16), ANAPC10(1), ANAPC2(4), ANAPC4(4), ANAPC5(6), ANAPC7(6), ATM(12), ATR(20), BUB1(3), BUB1B(9), CCNA1(13), CCNB2(3), CCNB3(28), CCND1(1), CCND2(5), CCND3(2), CCNE1(4), CCNE2(12), CCNH(2), CDC14A(4), CDC14B(1), CDC16(1), CDC20(1), CDC23(3), CDC25A(8), CDC25B(4), CDC25C(4), CDC27(9), CDC6(1), CDC7(2), CDK4(5), CDK6(2), CDKN1A(4), CDKN1B(1), CDKN2C(1), CHEK1(2), CHEK2(2), CREBBP(20), CUL1(5), DBF4(5), E2F1(5), E2F2(4), E2F3(5), EP300(14), ESPL1(14), FZR1(6), GADD45B(2), GSK3B(2), HDAC1(1), HDAC2(1), MAD1L1(5), MAD2L1(1), MAD2L2(1), MCM2(10), MCM3(10), MCM4(5), MCM5(4), MCM6(4), MDM2(3), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), PKMYT1(3), PLK1(3), PRKDC(18), PTTG1(1), PTTG2(5), RB1(8), RBL1(10), RBL2(4), SFN(1), SKP2(2), SMAD2(3), SMAD3(2), SMAD4(2), SMC1A(3), SMC1B(20), TFDP1(2), TGFB1(1), TGFB2(1), TGFB3(3), WEE1(2), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3) 45169962 460 168 446 179 257 40 32 87 42 2 0.0118 1.000 1.000 104 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 65 ADCY1(26), ADCY8(45), ARAF(4), ATF4(7), CACNA1C(43), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CAMK4(10), CHP(3), CREBBP(20), EP300(14), GNAQ(4), GRIA1(39), GRIA2(34), GRIN1(7), GRIN2A(86), GRIN2B(53), GRIN2C(8), GRIN2D(6), GRM1(16), GRM5(13), HRAS(3), ITPR1(29), ITPR2(17), ITPR3(6), KRAS(4), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PPP1CA(1), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PPP1R1A(4), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PRKACA(3), PRKACB(4), PRKACG(8), PRKCA(10), PRKCG(13), PRKX(3), RAF1(8), RAP1A(2), RAP1B(1), RAPGEF3(12), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KA6(15) 32209252 799 167 744 473 556 64 29 88 61 1 0.260 1.000 1.000 105 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(11), ABCA10(21), ABCA12(59), ABCA13(60), ABCA2(9), ABCA3(17), ABCA4(49), ABCA5(8), ABCA6(25), ABCA7(11), ABCA8(30), ABCA9(18), ABCB1(35), ABCB10(5), ABCB11(45), ABCB4(17), ABCB5(36), ABCB6(2), ABCB7(6), ABCB8(3), ABCB9(6), ABCC1(12), ABCC10(12), ABCC11(17), ABCC12(23), ABCC2(9), ABCC3(25), ABCC4(11), ABCC5(8), ABCC6(24), ABCC8(37), ABCC9(56), ABCD2(17), ABCD3(9), ABCD4(1), ABCG1(9), ABCG2(6), ABCG4(6), ABCG5(6), ABCG8(15), CFTR(44), TAP1(1), TAP2(13) 39346443 834 165 795 484 561 68 29 91 85 0 0.0301 1.000 1.000 106 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CALM1(1), CALM2(1), CALML3(6), CDS1(9), CDS2(4), DGKA(3), DGKB(22), DGKD(9), DGKE(6), DGKG(16), DGKH(8), DGKI(23), DGKQ(6), DGKZ(7), IMPA1(1), IMPA2(2), INPP1(2), INPP4A(5), INPP4B(2), INPP5A(4), INPP5B(6), INPP5D(31), INPPL1(15), ITPK1(6), ITPKB(6), ITPR1(29), ITPR2(17), ITPR3(6), OCRL(4), PI4KA(18), PI4KB(4), PIK3C2A(6), PIK3C2B(13), PIK3C2G(43), PIK3C3(3), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PIP4K2A(5), PIP4K2B(3), PIP4K2C(3), PIP5K1A(6), PIP5K1B(18), PIP5K1C(8), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PLCD1(3), PLCD3(3), PLCD4(2), PLCE1(48), PLCG1(9), PLCG2(25), PLCZ1(20), PRKCA(10), PRKCG(13), SYNJ1(20), SYNJ2(15) 41066241 768 164 716 367 536 41 29 94 66 2 0.00138 1.000 1.000 107 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 89 AKT1(3), AKT3(4), BCAR1(4), CAPN1(4), CAPN10(7), CAPN11(9), CAPN2(6), CAPN3(9), CAPN5(4), CAPN6(13), CAPN7(1), CAPN9(12), CAPNS1(1), CAV1(1), CDC42(2), CRK(2), CSK(1), DOCK1(15), FYN(6), GIT2(8), GRB2(2), ITGA10(7), ITGA11(16), ITGA2(11), ITGA2B(10), ITGA3(7), ITGA4(36), ITGA5(20), ITGA6(8), ITGA7(23), ITGA8(36), ITGA9(13), ITGAD(24), ITGAE(16), ITGAL(24), ITGAM(21), ITGAV(9), ITGAX(18), ITGB1(4), ITGB2(13), ITGB3(11), ITGB4(20), ITGB5(6), ITGB6(11), ITGB7(6), ITGB8(17), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K6(3), MAPK10(8), MAPK12(1), MAPK4(15), MAPK6(6), MAPK7(4), MYLK2(10), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PDPK1(4), PIK3R2(5), PTK2(8), PXN(3), RAC2(1), RAP1B(1), RAPGEF1(10), RHO(2), ROCK1(5), ROCK2(12), SDCCAG8(3), SEPP1(1), SHC1(1), SHC3(11), SORBS1(13), SOS1(8), SRC(1), TLN1(12), TNS1(9), VASP(3), VAV2(3), VAV3(9), VCL(7), ZYX(6) 44207233 735 164 714 336 497 53 26 94 64 1 0.000673 1.000 1.000 108 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 97 AKT1(3), AKT2(8), AKT3(4), CASP8(8), CD14(5), CD40(4), CD80(4), CD86(19), CHUK(2), CXCL10(3), CXCL11(1), CXCL9(2), FOS(2), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(9), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(5), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IKBKB(3), IKBKE(9), IL12A(3), IL12B(3), IL1B(6), IL6(2), IL8(1), IRAK1(4), IRAK4(3), IRF3(3), IRF5(4), IRF7(7), JUN(1), LBP(8), LY96(4), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K6(3), MAP2K7(4), MAP3K7(1), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK8(1), MAPK9(5), MYD88(3), NFKB1(7), NFKB2(4), NFKBIA(2), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), RELA(4), RIPK1(1), SPP1(7), STAT1(4), TBK1(5), TICAM1(9), TIRAP(1), TLR1(10), TLR2(15), TLR3(9), TLR4(31), TLR5(18), TLR6(5), TLR7(15), TLR8(8), TLR9(14), TNF(1), TOLLIP(1), TRAF3(5), TRAF6(4) 29762434 511 163 493 234 324 32 25 81 48 1 0.00642 1.000 1.000 109 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 94 ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADCY9(9), ATF4(7), CACNA1C(43), CACNA1D(29), CACNA1F(20), CACNA1S(46), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CDC42(2), CGA(1), EGFR(22), ELK1(2), FSHB(4), GNA11(7), GNAQ(4), GNAS(19), GNRH2(2), GNRHR(2), GRB2(2), HBEGF(1), HRAS(3), ITPR1(29), ITPR2(17), ITPR3(6), JUN(1), KRAS(4), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K6(3), MAP2K7(4), MAP3K1(2), MAP3K2(6), MAP3K3(6), MAP3K4(16), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK7(4), MAPK8(1), MAPK9(5), MMP14(2), MMP2(7), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PLD1(11), PLD2(5), PRKACA(3), PRKACB(4), PRKACG(8), PRKCA(10), PRKCD(4), PRKX(3), PTK2B(10), RAF1(8), SOS1(8), SOS2(11), SRC(1) 41918077 802 163 755 517 541 73 36 82 69 1 0.651 1.000 1.000 110 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 A4GNT(6), ALG1(2), ALG10(4), ALG10B(4), ALG12(1), ALG13(8), ALG14(2), ALG2(4), ALG3(4), ALG6(2), ALG8(6), ALG9(5), B3GNT1(2), B3GNT2(2), B3GNT7(4), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), B4GALT5(2), C1GALT1(6), C1GALT1C1(2), CHPF(3), CHST1(9), CHST11(5), CHST12(4), CHST13(3), CHST14(3), CHST2(4), CHST3(1), CHST4(9), CHST6(4), CHSY1(8), DAD1(1), DDOST(2), DPAGT1(2), EXT1(2), EXT2(6), EXTL1(2), EXTL3(10), FUT11(3), FUT8(8), GALNT1(4), GALNT10(6), GALNT11(2), GALNT12(8), GALNT13(25), GALNT14(27), GALNT2(6), GALNT3(3), GALNT4(4), GALNT5(9), GALNT6(15), GALNT7(5), GALNT8(23), GALNT9(5), GALNTL1(4), GALNTL2(19), GALNTL4(6), GALNTL5(14), GANAB(5), GCNT1(6), GCNT3(5), GCNT4(4), HS2ST1(1), HS3ST1(10), HS3ST2(7), HS3ST3A1(4), HS3ST3B1(2), HS3ST5(8), HS6ST1(3), HS6ST2(2), HS6ST3(12), MAN1A1(15), MAN1A2(4), MAN1B1(4), MAN1C1(7), MAN2A1(10), MGAT1(3), MGAT2(2), MGAT3(10), MGAT4A(8), MGAT4B(1), MGAT5(4), MGAT5B(9), NDST1(4), NDST2(2), NDST3(23), NDST4(45), OGT(10), RPN2(2), ST3GAL1(6), ST3GAL2(1), ST3GAL3(1), ST3GAL4(1), ST6GAL1(5), ST6GALNAC1(5), STT3B(5), WBSCR17(37), XYLT1(10), XYLT2(3) 36482472 655 161 628 349 444 51 27 70 63 0 0.0812 1.000 1.000 111 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 91 AKT1(3), AKT2(8), AKT3(4), BCL10(3), CARD11(32), CBL(8), CBLB(16), CBLC(14), CD247(3), CD28(1), CD3D(5), CD3E(2), CD3G(1), CD4(6), CD40LG(2), CD8A(2), CD8B(7), CDC42(2), CDK4(5), CHP(3), CHUK(2), CSF2(2), CTLA4(2), FOS(2), FYN(6), GRAP2(4), GRB2(2), HRAS(3), ICOS(3), IFNG(2), IKBKB(3), IL10(3), IL2(4), IL4(1), IL5(4), ITK(20), JUN(1), KRAS(4), LAT(1), LCK(12), LCP2(9), MALT1(7), MAP3K14(3), NCK1(1), NCK2(4), NFAT5(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PDCD1(3), PDK1(2), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PRKCQ(16), PTPN6(3), PTPRC(30), RASGRP1(7), RHOA(1), SOS1(8), SOS2(11), TEC(10), TNF(1), VAV1(15), VAV2(3), VAV3(9), ZAP70(7) 33736670 611 161 586 282 393 46 27 91 53 1 0.0633 1.000 1.000 112 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 122 ARAF(4), CASP3(2), CD244(8), CD247(3), CD48(4), CHP(3), CSF2(2), FAS(5), FASLG(14), FCER1G(1), FCGR3A(8), FCGR3B(2), FYN(6), GRB2(2), GZMB(3), HLA-A(3), HLA-B(5), HLA-C(1), HLA-E(1), HLA-G(3), HRAS(3), ICAM1(2), ICAM2(4), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(9), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(5), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IFNG(2), IFNGR1(4), IFNGR2(4), ITGAL(24), ITGB2(13), KIR2DL3(6), KIR2DL4(3), KIR3DL1(17), KIR3DL2(2), KLRC1(4), KLRC2(1), KLRC3(11), KLRD1(5), KLRK1(5), KRAS(4), LAT(1), LCK(12), LCP2(9), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), MICA(3), MICB(3), NCR1(13), NCR2(11), NCR3(3), NFAT5(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PAK1(4), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PLCG1(9), PLCG2(25), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PRF1(11), PRKCA(10), PRKCG(13), PTK2B(10), PTPN11(9), PTPN6(3), RAC2(1), RAF1(8), SH2D1A(2), SH2D1B(3), SH3BP2(2), SHC1(1), SHC2(7), SHC3(11), SHC4(2), SOS1(8), SOS2(11), SYK(14), TNF(1), TNFRSF10A(5), TNFRSF10B(2), TNFRSF10C(4), TNFRSF10D(7), TNFSF10(7), TYROBP(4), ULBP1(2), ULBP3(5), VAV1(15), VAV2(3), VAV3(9), ZAP70(7) 36702743 713 160 684 354 476 49 27 97 63 1 0.0764 1.000 1.000 113 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 90 ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADCY9(9), AKAP1(9), AKAP10(3), AKAP11(12), AKAP12(4), AKAP3(16), AKAP4(16), AKAP6(35), AKAP7(3), AKAP8(6), AKAP9(27), ARHGEF1(1), CALM1(1), CALM2(1), CHMP1B(1), GNA11(7), GNA12(3), GNA13(1), GNA14(5), GNA15(5), GNAI2(5), GNAI3(2), GNAL(2), GNAO1(2), GNAQ(4), GNAZ(6), GNB3(7), GNB5(2), GNG4(2), GNG7(2), GNGT2(4), HRAS(3), ITPR1(29), KCNJ3(18), KRAS(4), PDE1B(12), PDE1C(41), PDE4A(9), PDE4B(7), PDE4C(16), PDE4D(7), PDE7A(1), PDE7B(16), PDE8A(2), PDE8B(21), PLCB3(4), PPP3CA(5), PPP3CC(2), PRKACA(3), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), PRKCD(4), PRKCE(6), PRKCG(13), PRKCH(10), PRKCI(8), PRKCQ(16), PRKCZ(5), PRKD1(3), PRKD3(4), RHOA(1), RRAS(1), SLC9A1(3), USP5(4) 38488871 630 159 609 393 433 53 31 65 48 0 0.758 1.000 1.000 114 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(12), ACTN1(5), ACTR2(3), ACTR3(2), AKT1(3), AKT2(8), AKT3(4), ANGPTL2(2), ARHGEF6(10), ARHGEF7(3), BCAR1(4), CAV1(1), CDC42(2), CRK(2), CSE1L(5), DOCK1(15), EPHB2(29), FYN(6), GRB2(2), GRB7(5), GRLF1(11), ITGA1(18), ITGA10(7), ITGA11(16), ITGA2(11), ITGA3(7), ITGA4(36), ITGA5(20), ITGA6(8), ITGA7(23), ITGA8(36), ITGA9(13), ITGB3BP(2), MAP2K4(4), MAP2K7(4), MAP3K11(6), MAPK1(4), MAPK10(8), MAPK8(1), MAPK8IP1(4), MAPK8IP2(7), MAPK8IP3(8), MAPK9(5), MRAS(1), MYLK(39), MYLK2(10), P4HB(2), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PIK3CA(8), PIK3CB(21), PKLR(11), PLCG1(9), PLCG2(25), PTK2(8), RAF1(8), RALA(1), RHO(2), ROCK1(5), ROCK2(12), SHC1(1), SOS1(8), SOS2(11), SRC(1), TERF2IP(1), TLN1(12), TLN2(23), VASP(3), WAS(7), ZYX(6) 39667542 693 159 662 318 454 51 26 101 61 0 0.00502 1.000 1.000 115 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADCY9(9), ASIP(2), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CREB3(1), CREB3L1(4), CREB3L2(7), CREB3L3(9), CREB3L4(5), CREBBP(20), CTNNB1(11), DCT(3), DVL2(3), DVL3(7), EDN1(8), EDNRB(4), EP300(14), FZD1(4), FZD10(2), FZD2(5), FZD4(1), FZD5(2), FZD6(2), FZD7(4), FZD8(4), FZD9(1), GNAI1(1), GNAI2(5), GNAI3(2), GNAO1(2), GNAQ(4), GNAS(19), GSK3B(2), HRAS(3), KIT(9), KITLG(8), KRAS(4), LEF1(3), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), MITF(4), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), POMC(3), PRKACA(3), PRKACB(4), PRKACG(8), PRKCA(10), PRKCG(13), PRKX(3), RAF1(8), TCF7(1), TCF7L1(3), TCF7L2(7), TYR(8), TYRP1(8), WNT1(2), WNT10A(7), WNT10B(5), WNT11(4), WNT16(1), WNT2(7), WNT2B(4), WNT3(5), WNT3A(6), WNT4(2), WNT5A(5), WNT5B(5), WNT6(2), WNT7A(13), WNT7B(6), WNT8A(7), WNT8B(7), WNT9A(3), WNT9B(3) 35891068 662 158 623 387 434 57 31 74 65 1 0.236 1.000 1.000 116 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(17), AMY2A(5), AMY2B(10), ENPP1(11), ENPP3(14), G6PC(5), GAA(7), GANAB(5), GBA3(14), GBE1(8), GCK(17), GPI(3), GUSB(3), GYS1(3), GYS2(20), HK1(3), HK2(12), HK3(13), MGAM(133), PGM1(4), PGM3(1), PYGB(2), PYGL(7), PYGM(10), SI(71), UCHL1(4), UCHL3(2), UGDH(1), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(6), UGT1A9(10), UGT2B15(25), UGT2B4(31), UXS1(4) 18938008 544 158 505 237 381 56 22 43 41 1 0.000816 1.000 1.000 117 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(26), ASH2L(3), CARM1(6), CTCFL(20), DOT1L(8), EED(3), EHMT1(7), EHMT2(9), EZH1(5), EZH2(10), FBXO11(6), HCFC1(15), JMJD4(4), JMJD6(1), KDM6A(3), MEN1(2), MLL(39), MLL2(47), MLL3(61), MLL4(34), MLL5(12), NSD1(16), OGT(10), PAXIP1(3), PPP1CA(1), PPP1CB(5), PPP1CC(2), PRDM2(13), PRDM7(6), PRDM9(47), PRMT1(1), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), RBBP5(5), SATB1(14), SETD1A(23), SETD2(14), SETD7(2), SETD8(1), SETDB1(10), SETDB2(4), SETMAR(4), SMYD3(2), STK38(4), SUV39H1(1), SUV39H2(1), SUV420H1(7), SUV420H2(1), SUZ12(2), WHSC1(9), WHSC1L1(6) 39478641 552 157 534 195 355 56 21 70 50 0 0.00190 1.000 1.000 118 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 109 ADA(2), ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADK(4), ADSL(6), ADSS(2), AK1(1), AK2(3), AK5(6), ALLC(7), AMPD1(28), AMPD2(5), AMPD3(22), APRT(3), ATIC(5), ATP1B1(1), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(6), ATP5G2(1), ATP5H(1), ATP5J(2), CANT1(9), DGUOK(4), ENPP1(11), ENPP3(14), ENTPD1(10), ENTPD2(4), FHIT(2), GART(9), GDA(12), GMPS(4), GUCY1A2(18), GUCY1A3(29), GUCY1B3(7), GUCY2C(32), GUCY2D(8), GUCY2F(15), GUK1(2), IMPDH1(2), IMPDH2(1), NPR1(16), NPR2(14), NT5E(4), NT5M(2), PAICS(1), PAPSS1(3), PAPSS2(5), PDE4A(9), PDE4B(7), PDE4C(16), PDE4D(7), PDE5A(8), PDE6B(13), PDE6C(23), PDE6G(2), PDE7B(16), PDE8A(2), PDE9A(9), PFAS(8), PKLR(11), PKM2(5), POLD1(6), POLD2(2), POLE(15), POLG(8), POLL(7), POLQ(23), POLR1B(8), POLR2A(11), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(2), PRPS1(2), PRPS1L1(13), PRPS2(3), PRUNE(1), RRM1(3), RRM2(2) 42318372 727 157 694 383 502 61 26 69 69 0 0.0197 1.000 1.000 119 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 83 ABL1(12), ABL2(10), AKT1(3), AKT2(8), AKT3(4), ARAF(4), AREG(7), BTC(2), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CBL(8), CBLB(16), CBLC(14), CDKN1A(4), CDKN1B(1), CRK(2), CRKL(2), EGF(18), EGFR(22), EIF4EBP1(1), ELK1(2), ERBB2(7), ERBB3(5), ERBB4(47), EREG(4), GAB1(4), GRB2(2), GSK3B(2), HBEGF(1), HRAS(3), JUN(1), KRAS(4), MAP2K1(10), MAP2K2(3), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK3(1), MAPK8(1), MAPK9(5), MYC(5), NCK1(1), NCK2(4), NRG1(14), NRG2(7), NRG3(20), NRG4(1), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PLCG1(9), PLCG2(25), PRKCA(10), PRKCG(13), PTK2(8), RAF1(8), RPS6KB1(2), RPS6KB2(3), SHC1(1), SHC2(7), SHC3(11), SHC4(2), SOS1(8), SOS2(11), SRC(1), STAT5A(2), STAT5B(4), TGFA(2) 33615281 616 156 582 274 400 43 29 91 52 1 0.0205 1.000 1.000 120 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACP1(3), ACTB(7), ACTG1(5), ACTN1(5), ACTN2(21), ACTN3(7), ACTN4(5), ACVR1B(3), ACVR1C(9), BAIAP2(5), CDC42(2), CDH1(5), CREBBP(20), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(23), CTNNA3(28), CTNNB1(11), CTNND1(9), EGFR(22), EP300(14), ERBB2(7), FARP2(5), FER(3), FGFR1(11), FYN(6), IGF1R(10), INSR(20), IQGAP1(10), LEF1(3), LMO7(26), MAP3K7(1), MAPK1(4), MAPK3(1), MET(19), MLLT4(13), NLK(5), PARD3(15), PTPN1(4), PTPN6(3), PTPRB(79), PTPRF(27), PTPRJ(8), PTPRM(7), PVRL1(4), PVRL2(5), PVRL3(5), PVRL4(7), RAC2(1), RHOA(1), SMAD2(3), SMAD3(2), SMAD4(2), SNAI1(2), SNAI2(4), SORBS1(13), SRC(1), SSX2IP(5), TCF7(1), TCF7L1(3), TCF7L2(7), TGFBR2(7), TJP1(11), VCL(7), WAS(7), WASF1(4), WASF2(4), WASF3(12), WASL(5), YES1(5) 40028787 624 156 597 308 416 46 25 68 66 3 0.212 1.000 1.000 121 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(10), AGTR2(9), ATP8A1(22), AVPR1A(4), AVPR1B(9), AVPR2(1), BDKRB1(5), BDKRB2(9), BRS3(5), C3AR1(4), CCKAR(9), CCKBR(10), CCR1(9), CCR10(2), CCR2(16), CCR3(10), CCR4(7), CCR5(7), CCR6(2), CCR7(3), CCR8(6), CX3CR1(13), CXCR3(4), CXCR4(3), CXCR6(4), EDNRA(8), EDNRB(4), FPR1(18), FSHR(15), GALR1(5), GALR3(2), GALT(2), GHSR(8), GNB2L1(3), GNRHR(2), GPR77(5), GRPR(5), LHCGR(24), MC2R(5), MC3R(7), MC4R(1), MC5R(7), NMBR(6), NPY1R(25), NPY2R(12), NPY5R(22), NTSR1(6), NTSR2(3), OPRD1(2), OPRK1(21), OPRL1(5), OPRM1(5), OXTR(5), PPYR1(12), SSTR1(10), SSTR2(5), SSTR3(11), SSTR4(3), TACR1(7), TACR2(7), TACR3(25), TRHR(19), TSHR(8) 17484509 523 154 497 348 365 46 20 55 37 0 0.000644 1.000 1.000 122 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(2), ACVR1B(3), ACVRL1(9), AKT1(3), AURKB(2), BMPR1A(2), BMPR2(5), BUB1(3), CDKL1(5), CDKL2(2), CDS1(9), CDS2(4), CLK1(4), CLK2(6), COL4A3BP(3), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), DGKA(3), DGKB(22), DGKD(9), DGKE(6), DGKG(16), DGKH(8), DGKQ(6), DGKZ(7), IMPA1(1), INPP1(2), INPP4A(5), INPP4B(2), INPP5A(4), INPPL1(15), ITPKB(6), MAP3K10(8), MOS(5), NEK1(8), NEK3(2), OCRL(4), PAK4(4), PIK3C2A(6), PIK3C2B(13), PIK3C2G(43), PIK3CA(8), PIK3CB(21), PIK3CG(24), PIM2(4), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PLCD1(3), PLCG1(9), PLCG2(25), PLK3(2), PRKACA(3), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), PRKCD(4), PRKCE(6), PRKCG(13), PRKCH(10), PRKCQ(16), PRKCZ(5), PRKD1(3), PRKG1(12), RAF1(8), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KA4(4), RPS6KB1(2), STK11(3) 37505174 632 154 594 346 434 33 24 78 62 1 0.598 1.000 1.000 123 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 80 ABL1(12), ATM(12), BUB1(3), BUB1B(9), CCNA1(13), CCNB2(3), CCNB3(28), CCND2(5), CCND3(2), CCNE1(4), CCNE2(12), CCNH(2), CDAN1(5), CDC14A(4), CDC14B(1), CDC20(1), CDC25A(8), CDC25B(4), CDC25C(4), CDC6(1), CDC7(2), CDH1(5), CDK4(5), CDKN1A(4), CHEK1(2), CHEK2(2), DTX4(4), E2F1(5), E2F2(4), E2F3(5), E2F4(1), E2F5(1), EP300(14), ESPL1(14), GSK3B(2), HDAC1(1), HDAC2(1), HDAC3(5), HDAC4(10), HDAC5(6), HDAC6(2), HDAC8(3), MAD1L1(5), MAD2L1(1), MAD2L2(1), MCM2(10), MCM3(10), MCM4(5), MCM5(4), MCM6(4), MDM2(3), MPEG1(6), MPL(7), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), PLK1(3), PRKDC(18), PTPRA(7), PTTG1(1), PTTG2(5), RB1(8), RBL1(10), SKP2(2), SMAD4(2), TBC1D8(8), TFDP1(2), TGFB1(1), WEE1(2) 36212931 371 152 362 158 220 37 18 64 30 2 0.0313 1.000 1.000 124 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(2), ACVR1B(3), ACVR1C(9), ACVR2A(3), ACVR2B(3), ACVRL1(9), AMHR2(15), BMP2(4), BMP4(3), BMP5(25), BMP6(10), BMP7(2), BMP8A(2), BMP8B(1), BMPR1A(2), BMPR1B(3), BMPR2(5), CHRD(14), COMP(7), CREBBP(20), CUL1(5), DCN(17), E2F4(1), E2F5(1), EP300(14), FST(4), GDF5(13), GDF6(2), GDF7(2), ID2(2), IFNG(2), INHBA(16), INHBB(7), INHBC(11), INHBE(3), LEFTY1(7), LEFTY2(3), LTBP1(43), MAPK1(4), MAPK3(1), MYC(5), NODAL(2), NOG(1), PITX2(4), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(6), RBL1(10), RBL2(4), RHOA(1), ROCK1(5), ROCK2(12), RPS6KB1(2), RPS6KB2(3), SMAD1(5), SMAD2(3), SMAD3(2), SMAD4(2), SMAD5(3), SMAD6(7), SMAD7(2), SMAD9(10), SMURF1(1), SMURF2(9), SP1(5), TFDP1(2), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(7), THBS1(27), THBS2(9), THBS3(10), THBS4(11), TNF(1), ZFYVE16(4), ZFYVE9(8) 33158853 504 152 488 248 332 44 19 58 51 0 0.363 1.000 1.000 125 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(57), COL4A2(30), COL4A3(37), COL4A4(91), COL4A5(53), COL4A6(32), F10(8), F11(12), F12(1), F2(9), F2R(6), F5(30), F8(42), F9(12), FGA(38), FGB(10), FGG(7), KLKB1(23), PROC(8), PROS1(13), SERPINC1(7), SERPING1(12) 14839385 538 150 508 166 412 37 20 44 25 0 0.0537 1.000 1.000 126 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(9), AKR1D1(17), ARSD(3), ARSE(5), CARM1(6), CYP11B1(13), CYP11B2(13), CYP19A1(10), HEMK1(4), HSD11B1(11), HSD11B2(2), HSD17B12(2), HSD17B2(9), HSD17B3(5), HSD17B7(1), HSD3B1(10), HSD3B2(10), LCMT1(4), METTL2B(7), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), SRD5A1(2), SRD5A2(6), STS(7), SULT1E1(12), SULT2A1(7), SULT2B1(6), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(6), UGT1A9(10), UGT2A1(18), UGT2A3(24), UGT2B10(36), UGT2B11(19), UGT2B15(25), UGT2B28(24), UGT2B4(31), UGT2B7(17), WBSCR22(1) 16660968 481 149 447 202 333 45 23 32 47 1 1.28e-05 1.000 1.000 127 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 72 AKT1(3), AKT2(8), AKT3(4), BTK(15), CSF2(2), FCER1A(12), FCER1G(1), FYN(6), GAB2(4), GRB2(2), HRAS(3), IL13(2), IL3(3), IL4(1), IL5(4), INPP5D(31), KRAS(4), LAT(1), LCP2(9), LYN(6), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K6(3), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK8(1), MAPK9(5), MS4A2(10), PDK1(2), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PLCG1(9), PLCG2(25), PRKCA(10), PRKCD(4), PRKCE(6), RAC2(1), RAF1(8), SOS1(8), SOS2(11), SYK(14), TNF(1), VAV1(15), VAV2(3), VAV3(9) 23827398 458 148 437 194 290 29 19 71 48 1 0.00243 1.000 1.000 128 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ABP1(18), ACAT2(1), ACMSD(10), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2), AOC2(7), AOC3(8), AOX1(21), ASMT(6), CAT(5), CYP19A1(10), CYP1A1(10), CYP1A2(10), CYP2A13(11), CYP2A6(11), CYP2A7(8), CYP2B6(16), CYP2C18(26), CYP2C19(35), CYP2C8(30), CYP2C9(35), CYP2D6(1), CYP2E1(13), CYP2F1(11), CYP2J2(5), CYP3A4(19), CYP3A5(10), CYP3A7(18), CYP4B1(20), CYP4F8(15), CYP51A1(1), DDC(12), ECHS1(2), EHHADH(6), GCDH(5), HAAO(3), HADHA(8), KMO(8), KYNU(11), MAOA(3), MAOB(13), SDS(2), TDO2(5), TPH1(5), WARS(4), WARS2(4) 18324675 521 148 492 295 394 34 21 38 34 0 0.0497 1.000 1.000 129 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 CPEB1(8), EGFR(22), ERBB2(7), ERBB4(47), ETS1(4), ETS2(8), ETV6(11), ETV7(3), FMN2(71), GRB2(2), KRAS(4), MAP2K1(10), MAPK1(4), MAPK3(1), NOTCH1(5), NOTCH2(37), NOTCH3(23), NOTCH4(54), PIWIL1(20), PIWIL2(11), PIWIL3(13), PIWIL4(4), RAF1(8), SOS1(8), SOS2(11), SPIRE1(2), SPIRE2(6) 17033669 404 147 385 169 276 23 13 64 28 0 0.0593 1.000 1.000 130 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(2), CDC40(4), CLK2(6), CLK3(2), COL2A1(29), CPSF1(6), CPSF2(2), CPSF3(4), CSTF1(5), CSTF2(4), CSTF2T(3), CSTF3(5), DDIT3(2), DDX1(2), DDX20(8), DHX15(4), DHX16(8), DHX38(9), DHX8(11), DHX9(8), DICER1(17), DNAJC8(2), GIPC1(4), LOC440563(21), LSM2(2), LSM7(1), METTL3(2), NCBP1(1), NONO(8), NUDT21(3), NXF1(4), PABPN1(1), PAPOLA(4), PHF5A(1), POLR2A(11), PPM1G(2), PRPF18(4), PRPF3(4), PRPF4(3), PRPF4B(5), PRPF8(12), PSKH1(2), PTBP1(1), PTBP2(7), RBM17(1), RBM5(7), RNGTT(1), RNMT(8), RNPS1(1), SF3A1(7), SF3A2(5), SF3A3(4), SF3B1(14), SF3B2(9), SF3B4(5), SF4(8), SFRS12(2), SFRS14(13), SFRS16(5), SFRS4(2), SFRS5(3), SFRS6(2), SFRS7(2), SFRS8(7), SFRS9(2), SNRPA(2), SNRPA1(1), SNRPB(5), SNRPB2(1), SNRPD1(1), SNRPE(2), SNRPN(5), SNURF(2), SPOP(2), SRPK1(8), SRPK2(2), SRRM1(7), SUPT5H(7), TXNL4A(1), U2AF2(3), XRN2(5) 35579573 408 147 401 178 246 37 22 55 48 0 0.449 1.000 1.000 131 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(7), BCL2(2), CABIN1(9), CALM1(1), CALM2(1), CAMK2B(4), CAMK4(10), CD3E(2), CD3G(1), CD69(4), CDKN1A(4), CNR1(9), CREBBP(20), CSF2(2), CSNK2A1(1), CSNK2B(1), CTLA4(2), EGR2(4), EGR3(2), EP300(14), FCER1A(12), FCGR3A(8), FOS(2), GATA3(8), GATA4(2), GRLF1(11), GSK3B(2), HRAS(3), ICOS(3), IFNA1(1), IFNB1(6), IFNG(2), IL10(3), IL13(2), IL1B(6), IL2(4), IL2RA(4), IL3(3), IL4(1), IL6(2), IL8(1), ITK(20), KPNA5(1), MAP2K7(4), MAPK14(5), MAPK8(1), MAPK9(5), MEF2A(5), MEF2B(2), MEF2D(4), MYF5(13), NCK2(4), NFAT5(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB2(4), NFKBIB(1), NPPB(5), NUP214(12), OPRD1(2), P2RX7(5), PAK1(4), PIN1(1), PPIA(1), PPP3CB(4), PPP3CC(2), PPP3R1(1), PTPRC(30), RELA(4), RPL13A(2), SFN(1), SLA(2), SP1(5), SP3(1), TGFB1(1), TNF(1), TRAF2(2), TRPV6(29), VAV1(15), VAV2(3), VAV3(9), XPO5(7) 30429423 457 145 440 228 307 30 21 49 50 0 0.181 1.000 1.000 132 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 52 ADORA3(12), ALG6(2), CCKBR(10), CCR2(16), CCR3(10), CCR5(7), CELSR1(25), CELSR2(23), CELSR3(31), CHRM2(18), CHRM3(19), CXCR3(4), DRD4(1), EDNRA(8), EMR2(4), EMR3(18), F2R(6), FSHR(15), GHRHR(4), GNRHR(2), GPR116(33), GPR132(3), GPR133(13), GPR143(3), GPR17(1), GPR18(5), GPR55(4), GPR56(4), GPR61(8), GPR77(5), GPR84(8), GRM1(16), GRPR(5), HRH4(5), LGR6(17), LPHN2(34), LPHN3(20), LTB4R2(1), NTSR1(6), OR2M4(12), OR8G2(16), P2RY13(4), PTGFR(20), SMO(10), SSTR2(5), TAAR5(3), TSHR(8) 22218291 504 145 484 324 333 43 21 66 40 1 0.150 1.000 1.000 133 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 60 AKT1(3), AKT2(8), AKT3(4), BCL10(3), BLNK(12), BTK(15), CARD11(32), CD19(7), CD22(22), CD72(4), CD79A(2), CD79B(1), CD81(2), CHP(3), CHUK(2), CR2(32), FCGR2B(3), FOS(2), GSK3B(2), HRAS(3), IKBKB(3), INPP5D(31), JUN(1), KRAS(4), LILRB3(6), LYN(6), MALT1(7), NFAT5(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PLCG2(25), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PTPN6(3), RAC2(1), RASGRP3(13), SYK(14), VAV1(15), VAV2(3), VAV3(9) 24618622 471 145 457 197 299 28 26 67 50 1 0.00129 1.000 1.000 134 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 79 AIFM1(1), AKT1(3), AKT2(8), AKT3(4), APAF1(6), ATM(12), BAX(3), BCL2(2), BIRC2(5), BIRC3(7), CAPN1(4), CAPN2(6), CASP10(4), CASP3(2), CASP7(4), CASP8(8), CASP9(3), CFLAR(4), CHP(3), CHUK(2), CSF2RB(17), CYCS(1), DFFA(2), DFFB(3), FAS(5), FASLG(14), IKBKB(3), IL1A(4), IL1B(6), IL1R1(11), IL1RAP(4), IL3(3), IL3RA(7), IRAK1(4), IRAK2(14), IRAK3(7), IRAK4(3), MAP3K14(3), MYD88(3), NFKB1(7), NFKB2(4), NFKBIA(2), NTRK1(15), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PRKACA(3), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RELA(4), RIPK1(1), TNF(1), TNFRSF10A(5), TNFRSF10B(2), TNFRSF10C(4), TNFRSF10D(7), TNFRSF1A(3), TNFSF10(7), TRAF2(2) 27498632 395 143 386 207 242 27 18 67 40 1 0.571 1.000 1.000 135 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 46 IMPA1(1), IMPA2(2), INPP1(2), INPP4A(5), INPP4B(2), INPP5A(4), INPP5B(6), INPPL1(15), IPMK(2), ISYNA1(1), ITPK1(6), ITPKB(6), MINPP1(1), MIOX(3), OCRL(4), PI4KA(18), PI4KB(4), PIK3C3(3), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIP4K2A(5), PIP4K2B(3), PIP4K2C(3), PIP5K1A(6), PIP5K1B(18), PIP5K1C(8), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PLCD1(3), PLCD3(3), PLCD4(2), PLCE1(48), PLCG1(9), PLCG2(25), PLCZ1(20), SYNJ1(20), SYNJ2(15) 24382698 463 142 435 210 314 24 21 67 36 1 0.00381 1.000 1.000 136 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 53 ADH1A(14), ADH1B(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), AGK(6), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPAT6(2), AKR1A1(3), AKR1B1(2), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), CEL(11), DAK(3), DGAT1(1), DGAT2(6), DGKA(3), DGKB(22), DGKD(9), DGKE(6), DGKG(16), DGKH(8), DGKI(23), DGKQ(6), DGKZ(7), GK(6), GLA(1), GLB1(8), GPAM(5), LCT(40), LIPA(4), LIPC(8), LIPF(15), LIPG(6), LPL(3), MGLL(6), PNLIP(7), PNLIPRP1(10), PNLIPRP2(2), PNPLA3(2), PPAP2B(6), PPAP2C(8) 19035594 405 141 375 190 276 38 16 47 28 0 0.00603 1.000 1.000 137 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 66 ACAA1(5), ACADL(4), ACADM(5), ACOX1(7), ACOX2(7), ACOX3(11), ACSL1(4), ACSL3(6), ACSL4(2), ACSL5(20), ACSL6(13), ADIPOQ(3), ANGPTL4(4), APOA1(2), APOA5(6), AQP7(3), CD36(4), CPT1A(10), CPT1B(10), CPT1C(13), CPT2(1), CYP27A1(4), CYP4A11(23), CYP4A22(19), CYP7A1(8), CYP8B1(12), DBI(1), EHHADH(6), FABP1(6), FABP2(6), FABP3(1), FABP4(1), FADS2(3), GK(6), HMGCS2(17), LPL(3), ME1(19), MMP1(11), NR1H3(3), OLR1(5), PCK1(23), PCK2(4), PDPK1(4), PLTP(1), PPARA(6), PPARD(3), PPARG(11), RXRA(4), RXRB(4), RXRG(5), SCD(3), SCP2(2), SLC27A1(3), SLC27A2(12), SLC27A4(4), SLC27A5(6), SLC27A6(27), SORBS1(13), UBC(6), UCP1(4) 21565199 439 140 421 242 313 37 16 37 35 1 0.208 1.000 1.000 138 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 67 AKT1(3), AKT2(8), AKT3(4), CASP9(3), CDC42(2), CHP(3), HRAS(3), KDR(42), KRAS(4), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPKAPK2(5), MAPKAPK3(3), NFAT5(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NOS3(16), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PLCG1(9), PLCG2(25), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PRKCA(10), PRKCG(13), PTGS2(10), PTK2(8), PXN(3), RAC2(1), RAF1(8), SH2D2A(3), SHC2(7), SPHK1(1), SPHK2(7), SRC(1), VEGFA(5) 23797486 447 139 428 198 289 23 14 74 46 1 0.00840 1.000 1.000 139 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 63 ATM(12), CCNA1(13), CCND1(1), CCND2(5), CCND3(2), CCNE1(4), CCNE2(12), CCNH(2), CDC25A(8), CDK4(5), CDKN1A(4), CDKN1B(1), CDKN2C(1), CREB3(1), CREB3L1(4), CREB3L3(9), CREB3L4(5), E2F1(5), E2F2(4), E2F3(5), E2F4(1), E2F5(1), GBA2(2), MCM2(10), MCM3(10), MCM4(5), MCM5(4), MCM6(4), MDM2(3), MNAT1(2), MYC(5), MYT1(21), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), POLA2(8), POLE(15), POLE2(3), PRIM1(3), RB1(8), RBL1(10), RPA1(3), RPA2(2), RPA3(1), TFDP1(2), TFDP2(4), TNXB(128), WEE1(2) 25955051 375 137 361 160 231 27 12 69 34 2 0.0274 1.000 1.000 140 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 47 ACCN1(11), ADCY4(4), ADCY6(6), ADCY8(45), CACNA1A(32), CACNA1B(26), GNAS(19), GNAT3(3), GNB3(7), GRM4(19), ITPR3(6), KCNB1(31), PLCB2(9), PRKACA(3), PRKACB(4), PRKACG(8), PRKX(3), SCNN1A(7), SCNN1B(13), SCNN1G(26), TAS1R1(10), TAS1R2(23), TAS1R3(2), TAS2R1(8), TAS2R10(7), TAS2R13(2), TAS2R14(2), TAS2R16(8), TAS2R3(1), TAS2R38(14), TAS2R39(10), TAS2R4(3), TAS2R40(4), TAS2R41(12), TAS2R42(2), TAS2R43(1), TAS2R46(2), TAS2R5(3), TAS2R50(1), TAS2R60(16), TAS2R7(3), TAS2R8(4), TAS2R9(6), TRPM5(13) 18515639 439 136 417 382 297 34 19 49 40 0 0.984 1.000 1.000 141 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT1(3), AKT2(8), AKT3(4), DAG1(5), DRD2(15), EGFR(22), EPHB2(29), GRB2(2), ITPKB(6), ITPR1(29), ITPR2(17), ITPR3(6), KCNJ3(18), KCNJ5(12), KCNJ9(4), MAPK1(4), PI3(6), PIK3CB(21), PITX2(4), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), RAF1(8), RGS20(2), SHC1(1), SOS1(8), SOS2(11), SRC(1), STAT3(10), TERF2IP(1) 19034404 387 135 359 200 253 31 22 48 32 1 0.0855 1.000 1.000 142 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(7), AGT(5), AGTR1(10), AGTR2(9), CMA1(5), COL4A1(57), COL4A2(30), COL4A3(37), COL4A4(91), COL4A5(53), COL4A6(32), REN(9) 8428727 345 134 324 102 282 17 8 23 15 0 0.490 1.000 1.000 143 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 82 ATF2(5), CHUK(2), DAXX(9), ELK1(2), FOS(2), GRB2(2), HRAS(3), IKBKB(3), JUN(1), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K5(3), MAP2K6(3), MAP2K7(4), MAP3K1(2), MAP3K10(8), MAP3K11(6), MAP3K12(3), MAP3K13(10), MAP3K14(3), MAP3K2(6), MAP3K3(6), MAP3K4(16), MAP3K5(16), MAP3K6(6), MAP3K7(1), MAP3K9(22), MAP4K1(9), MAP4K2(6), MAP4K3(8), MAP4K4(7), MAP4K5(3), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK4(15), MAPK6(6), MAPK7(4), MAPK8(1), MAPK9(5), MAPKAPK2(5), MAPKAPK3(3), MAPKAPK5(1), MEF2A(5), MEF2B(2), MEF2C(2), MEF2D(4), MKNK1(5), MKNK2(2), MYC(5), NFKB1(7), NFKBIA(2), PAK1(4), PAK2(8), RAF1(8), RELA(4), RIPK1(1), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KA4(4), RPS6KA5(4), RPS6KB1(2), RPS6KB2(3), SHC1(1), SP1(5), STAT1(4), TGFB1(1), TGFB2(1), TGFB3(3), TRAF2(2) 30910335 369 134 357 192 220 41 16 58 34 0 0.674 1.000 1.000 144 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(3), ACP2(2), ACP5(3), ACPP(8), ALPI(8), ALPL(9), ALPP(9), ALPPL2(11), CYP19A1(10), CYP1A1(10), CYP1A2(10), CYP2A13(11), CYP2A6(11), CYP2A7(8), CYP2B6(16), CYP2C18(26), CYP2C19(35), CYP2C8(30), CYP2C9(35), CYP2D6(1), CYP2E1(13), CYP2F1(11), CYP2J2(5), CYP3A4(19), CYP3A5(10), CYP3A7(18), CYP4B1(20), CYP4F8(15), CYP51A1(1), PON1(14) 9717151 382 133 353 210 303 21 12 18 28 0 0.00151 1.000 1.000 145 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 55 ABP1(18), ADH1A(14), ADH1B(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), ALDH1A3(2), ALDH3A1(5), ALDH3B1(2), ALDH3B2(7), AOC2(7), AOC3(8), AOX1(21), CARM1(6), COMT(3), DBH(13), DCT(3), DDC(12), ECH1(1), ESCO1(1), ESCO2(2), FAH(4), GOT1(6), GOT2(5), HEMK1(4), HGD(12), HPD(5), LCMT1(4), MAOA(3), MAOB(13), METTL2B(7), METTL6(2), MYST3(15), MYST4(14), NAT6(2), PNMT(4), PNPLA3(2), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), SH3GLB1(2), TAT(17), TH(9), TPO(40), TYR(8), TYRP1(8), WBSCR22(1) 19589779 406 133 386 208 295 33 22 35 21 0 0.0840 1.000 1.000 146 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 63 ACSS1(1), ACSS2(4), ADH1A(14), ADH1B(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), AKR1A1(3), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH7A1(9), ALDH9A1(2), ALDOA(2), ALDOB(12), ALDOC(3), BPGM(2), DLAT(2), DLD(2), ENO1(4), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(5), G6PC2(4), GALM(2), GAPDH(1), GAPDHS(1), GCK(17), GPI(3), HK1(3), HK2(12), HK3(13), LDHA(5), LDHAL6A(4), LDHAL6B(7), LDHB(2), LDHC(5), PDHA1(3), PDHA2(17), PDHB(1), PFKL(4), PFKM(1), PGAM2(3), PGK1(4), PGK2(27), PGM1(4), PGM3(1), PKLR(11), PKM2(5) 19198247 337 132 308 158 236 27 18 34 22 0 0.00122 1.000 1.000 147 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(1), APH1A(2), CREBBP(20), CTBP2(1), DLL1(2), DLL3(6), DLL4(6), DTX1(8), DTX2(3), DTX3(4), DTX3L(6), DTX4(4), DVL2(3), DVL3(7), EP300(14), HDAC1(1), HDAC2(1), HES1(2), JAG1(8), JAG2(7), LFNG(3), MAML1(4), MAML2(6), MAML3(7), MFNG(7), NCOR2(24), NCSTN(4), NOTCH1(5), NOTCH2(37), NOTCH3(23), NOTCH4(54), NUMB(4), NUMBL(4), PSEN1(1), PSEN2(2), PTCRA(3), RBPJ(4), RBPJL(3), SNW1(2) 22959459 303 132 299 161 179 29 11 60 24 0 0.787 1.000 1.000 148 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(17), ACSL1(4), ACSL3(6), ACSL4(2), ACSL5(20), ACSL6(13), ADIPOQ(3), ADIPOR1(5), ADIPOR2(1), AGRP(1), AKT1(3), AKT2(8), AKT3(4), CAMKK1(3), CAMKK2(7), CD36(4), CHUK(2), CPT1A(10), CPT1B(10), CPT1C(13), CPT2(1), G6PC(5), G6PC2(4), IKBKB(3), IRS1(5), IRS2(2), IRS4(12), JAK1(6), JAK2(9), JAK3(6), LEP(2), LEPR(22), MAPK10(8), MAPK8(1), MAPK9(5), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NPY(4), PCK1(23), PCK2(4), POMC(3), PPARA(6), PPARGC1A(20), PRKAA1(1), PRKAA2(24), PRKAB1(2), PRKAB2(2), PRKAG1(2), PRKAG2(7), PRKAG3(10), PRKCQ(16), PTPN11(9), RELA(4), RXRA(4), RXRB(4), RXRG(5), SLC2A1(4), SLC2A4(8), SOCS3(2), STAT3(10), STK11(3), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF2(2), TYK2(7) 27751707 434 132 419 244 270 44 22 47 51 0 0.569 1.000 1.000 149 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(9), CAD(15), CANT1(9), CDA(2), CTPS(2), CTPS2(3), DCTD(2), DHODH(3), DPYD(56), DPYS(22), ENTPD1(10), ENTPD3(6), ENTPD4(4), ENTPD5(1), ENTPD6(4), ENTPD8(2), NME6(2), NME7(4), NT5C1A(3), NT5C1B(22), NT5C2(3), NT5C3(2), NT5E(4), NT5M(2), PNPT1(1), POLA1(2), POLA2(8), POLD1(6), POLD2(2), POLD3(4), POLE(15), POLE2(3), POLR1A(11), POLR1B(8), POLR1C(1), POLR2A(11), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(4), POLR3B(15), POLR3G(1), POLR3GL(1), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(14), RRM1(3), RRM2(2), RRM2B(2), TK2(1), TXNRD1(5), TXNRD2(3), TYMS(1), UCK1(2), UMPS(1), UPB1(6), UPP2(5), UPRT(1) 27093083 357 131 339 181 231 31 17 51 27 0 0.249 1.000 1.000 150 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(4), AGT(5), AKT1(3), CALM1(1), CALM2(1), CALR(1), CAMK1(4), CAMK1G(9), CAMK4(10), CREBBP(20), CSNK1A1(2), EDN1(8), ELSPBP1(4), F2(9), FGF2(2), FKBP1A(2), GATA4(2), GSK3B(2), HAND1(2), HAND2(5), HRAS(3), IGF1(11), LIF(2), MAP2K1(10), MAPK1(4), MAPK14(5), MAPK3(1), MAPK8(1), MEF2C(2), MYH2(77), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NKX2-5(1), NPPA(3), PIK3CA(8), PIK3R1(3), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RAF1(8), RPS6KB1(2), SYT1(19) 16985356 335 131 313 183 235 26 15 33 25 1 0.494 1.000 1.000 151 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 46 ACAA1(5), ACAA2(1), ACADL(4), ACADM(5), ACADS(4), ACADSB(6), ACADVL(1), ACAT2(1), ACOX1(7), ACOX3(11), ACSL1(4), ACSL3(6), ACSL4(2), ACSL5(20), ACSL6(13), ADH1A(14), ADH1B(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), CPT1A(10), CPT1B(10), CPT1C(13), CPT2(1), CYP4A11(23), CYP4A22(19), DCI(2), ECHS1(2), EHHADH(6), GCDH(5), HADHA(8), HADHB(4), HSD17B10(2), HSD17B4(6), PECI(2) 16191549 319 130 298 143 229 25 18 23 23 1 0.00877 1.000 1.000 152 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(4), AKT1(3), BDKRB2(9), CALM1(1), CALM2(1), CAV1(1), CHRM1(5), CHRNA1(5), FLT1(33), FLT4(23), KDR(42), NOS3(16), PDE2A(13), PDE3A(24), PDE3B(6), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKG1(12), PRKG2(13), RYR2(84), SLC7A1(3), SYT1(19), TNNI1(1) 13607606 340 130 321 197 240 26 10 32 31 1 0.338 1.000 1.000 153 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 61 AKT1(3), AKT2(8), AKT3(4), CDC42(2), CDKN1B(1), CREB3(1), CREB5(9), ERBB4(47), F2RL2(6), GAB1(4), GRB2(2), GSK3B(2), IFI27(2), IGF1(11), IGFBP1(3), INPPL1(15), IRS1(5), IRS2(2), IRS4(12), MET(19), MYC(5), NOLC1(4), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PARD3(15), PARD6A(1), PDK1(2), PIK3CA(8), PIK3CD(7), PPP1R13B(6), PREX1(7), PTK2(8), PTPN1(4), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(1), SLC2A4(8), SOS1(8), SOS2(11), TSC1(5), TSC2(11), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3) 25365237 369 130 354 182 224 36 17 52 39 1 0.277 1.000 1.000 154 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 44 ADH1A(14), ADH1B(27), ADH4(11), ADH6(11), ADH7(13), ADHFE1(5), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AKR1A1(3), AKR1B1(2), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2), CEL(11), DGAT1(1), DGKA(3), DGKB(22), DGKD(9), DGKE(6), DGKG(16), DGKH(8), DGKQ(6), DGKZ(7), GK(6), GLA(1), GLB1(8), LCT(40), LIPC(8), LIPF(15), LIPG(6), LPL(3), PNLIP(7), PNLIPRP1(10), PNLIPRP2(2), PPAP2B(6), PPAP2C(8) 15878981 351 129 325 169 250 32 13 35 21 0 0.0117 1.000 1.000 155 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(4), BMP4(3), BMP5(25), BMP6(10), BMP7(2), BMP8A(2), BMP8B(1), BTRC(4), CSNK1A1(2), CSNK1A1L(5), CSNK1D(1), CSNK1E(4), CSNK1G1(4), CSNK1G2(2), CSNK1G3(3), DHH(1), FBXW11(5), GLI1(14), GLI2(36), GLI3(15), GSK3B(2), HHIP(21), IHH(2), LRP2(87), PRKACA(3), PRKACB(4), PRKACG(8), PRKX(3), PTCH1(8), PTCH2(16), RAB23(1), SHH(4), SMO(10), STK36(13), SUFU(2), WNT1(2), WNT10A(7), WNT10B(5), WNT11(4), WNT16(1), WNT2(7), WNT2B(4), WNT3(5), WNT3A(6), WNT4(2), WNT5A(5), WNT5B(5), WNT6(2), WNT7A(13), WNT7B(6), WNT8A(7), WNT8B(7), WNT9A(3), WNT9B(3), ZIC2(2) 20127806 423 129 402 208 292 37 19 41 34 0 0.0342 1.000 1.000 156 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(12), ACTB(7), ACTG1(5), ARHGEF2(17), ARPC5(1), CD14(5), CDC42(2), CDH1(5), CLDN1(5), CTNNB1(11), CTTN(2), EZR(1), FYN(6), HCLS1(9), ITGB1(4), KRT18(3), LY96(4), NCK1(1), NCK2(4), NCL(6), OCLN(4), PRKCA(10), RHOA(1), ROCK1(5), ROCK2(12), TLR4(31), TLR5(18), TUBA1A(2), TUBA1B(4), TUBA1C(2), TUBA3C(21), TUBA3D(11), TUBA3E(3), TUBA4A(6), TUBA8(3), TUBAL3(11), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(5), TUBB4(3), TUBB4Q(9), TUBB6(10), WAS(7), WASL(5), YWHAQ(3) 17269075 303 129 290 128 197 29 11 34 32 0 0.00238 1.000 1.000 157 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(12), ACTB(7), ACTG1(5), ARHGEF2(17), ARPC5(1), CD14(5), CDC42(2), CDH1(5), CLDN1(5), CTNNB1(11), CTTN(2), EZR(1), FYN(6), HCLS1(9), ITGB1(4), KRT18(3), LY96(4), NCK1(1), NCK2(4), NCL(6), OCLN(4), PRKCA(10), RHOA(1), ROCK1(5), ROCK2(12), TLR4(31), TLR5(18), TUBA1A(2), TUBA1B(4), TUBA1C(2), TUBA3C(21), TUBA3D(11), TUBA3E(3), TUBA4A(6), TUBA8(3), TUBAL3(11), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(5), TUBB4(3), TUBB4Q(9), TUBB6(10), WAS(7), WASL(5), YWHAQ(3) 17269075 303 129 290 128 197 29 11 34 32 0 0.00238 1.000 1.000 158 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(3), AKT2(8), AKT3(4), BCL2(2), BCR(10), BLNK(12), BTK(15), CD19(7), CD22(22), CD81(2), CR2(32), CSK(1), DAG1(5), FLOT1(2), GRB2(2), GSK3B(2), INPP5D(31), ITPR1(29), ITPR2(17), ITPR3(6), LYN(6), MAP4K1(9), MAPK1(4), MAPK3(1), NFATC1(15), NFATC2(9), NR0B2(6), PDK1(2), PIK3CA(8), PIK3CD(7), PIK3R1(3), PLCG2(25), PPP1R13B(6), PPP3CA(5), PPP3CB(4), PPP3CC(2), PTPRC(30), RAF1(8), SHC1(1), SOS1(8), SOS2(11), SYK(14), VAV1(15) 24674181 411 128 396 195 268 30 24 45 43 1 0.0198 1.000 1.000 159 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(5), ALAS1(1), ALAS2(5), BLVRA(2), BLVRB(1), COX10(5), COX15(4), CP(11), CPOX(4), EPRS(9), FECH(3), FTH1(3), FTMT(7), GUSB(3), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), MMAB(2), PPOX(3), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(6), UGT1A9(10), UGT2A1(18), UGT2A3(24), UGT2B10(36), UGT2B11(19), UGT2B15(25), UGT2B28(24), UGT2B4(31), UGT2B7(17), UROS(1) 14078252 347 127 323 136 239 30 18 21 38 1 0.000367 1.000 1.000 160 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 61 APAF1(6), ATM(12), ATR(20), BAI1(14), BAX(3), CASP3(2), CASP8(8), CASP9(3), CCNB2(3), CCNB3(28), CCND1(1), CCND2(5), CCND3(2), CCNE1(4), CCNE2(12), CCNG1(1), CDK4(5), CDK6(2), CDKN1A(4), CHEK1(2), CHEK2(2), CYCS(1), DDB2(3), EI24(3), FAS(5), GADD45B(2), GTSE1(9), IGF1(11), IGFBP3(2), LRDD(4), MDM2(3), MDM4(2), PERP(2), PPM1D(2), RFWD2(4), RPRM(1), RRM2(2), RRM2B(2), SERPINB5(8), SERPINE1(5), SESN2(6), SESN3(1), SFN(1), STEAP3(6), THBS1(27), TNFRSF10B(2), TP53I3(2), TP73(5), TSC2(11), ZMAT3(1) 20934390 272 127 263 133 162 22 17 45 25 1 0.395 1.000 1.000 161 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 ALG2(4), BAX(3), BTK(15), CAD(15), CASP10(4), CASP3(2), CASP8(8), CASP8AP2(7), CDK2AP1(2), CSNK1A1(2), DAXX(9), DEDD(1), DEDD2(3), DFFA(2), DIABLO(1), EGFR(22), EPHB2(29), FAF1(7), FAIM2(5), HSPB1(2), IL1A(4), IL8(1), MAP2K4(4), MAP2K7(4), MAP3K1(2), MAP3K5(16), MAPK1(4), MAPK10(8), MAPK8(1), MAPK8IP1(4), MAPK8IP2(7), MAPK8IP3(8), MAPK9(5), MET(19), NFAT5(7), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), NR0B2(6), PTPN13(12), RALBP1(2), RIPK1(1), ROCK1(5), SMPD1(3), TNFRSF6B(2), TPX2(9), TRAF2(2), TUFM(5) 23980588 305 125 298 171 182 23 17 45 38 0 0.837 1.000 1.000 162 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(3), AKT2(8), AKT3(4), BCR(10), BTK(15), CD19(7), DAPP1(5), FLOT1(2), GAB1(4), ITPR1(29), ITPR2(17), ITPR3(6), LYN(6), NR0B2(6), PDK1(2), PIK3CA(8), PITX2(4), PLCG2(25), PPP1R13B(6), PREX1(7), PTPRC(30), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KB1(2), SAG(9), SYK(14), TEC(10), VAV1(15) 17915538 269 124 253 157 180 19 16 28 26 0 0.366 1.000 1.000 163 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(57), COL4A2(30), COL4A3(37), COL4A4(91), COL4A5(53), COL4A6(32), P4HB(2), SLC23A1(4), SLC23A2(4), SLC2A1(4), SLC2A3(7) 8332233 321 124 302 86 265 14 9 20 13 0 0.0976 1.000 1.000 164 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(19), AXIN1(10), CCND1(1), CCND2(5), CCND3(2), CSNK1E(4), CTNNB1(11), DVL2(3), DVL3(7), FBXW2(2), FZD1(4), FZD10(2), FZD2(5), FZD5(2), FZD6(2), FZD7(4), FZD8(4), FZD9(1), GSK3B(2), JUN(1), LDLR(14), MAPK10(8), MAPK9(5), MYC(5), PAFAH1B1(4), PLAU(3), PPP2R5C(4), PPP2R5E(4), PRKCA(10), PRKCD(4), PRKCE(6), PRKCG(13), PRKCH(10), PRKCI(8), PRKCQ(16), PRKCZ(5), PRKD1(3), RHOA(1), SFRP4(6), TCF7(1), WNT1(2), WNT10A(7), WNT10B(5), WNT11(4), WNT16(1), WNT2(7), WNT2B(4), WNT3(5), WNT4(2), WNT5A(5), WNT5B(5), WNT6(2), WNT7A(13), WNT7B(6) 19774605 289 124 283 161 181 29 8 34 37 0 0.392 1.000 1.000 165 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 43 ACTR2(3), ACTR3(2), AKT1(3), AKT2(8), AKT3(4), ANGPTL2(2), ARHGAP1(2), ARHGAP4(2), ARHGEF11(17), BTK(15), CDC42(2), CFL1(1), GDI1(1), GDI2(2), INPPL1(15), ITPR1(29), ITPR2(17), ITPR3(6), LIMK1(4), MYLK(39), MYLK2(10), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PDK1(2), PIK3CA(8), PIK3CD(7), PIK3CG(24), PIK3R1(3), PITX2(4), PPP1R13B(6), RACGAP1(3), RHO(2), ROCK1(5), ROCK2(12), SAG(9), WASF1(4), WASL(5) 23092803 354 123 333 163 233 31 12 49 28 1 0.0128 1.000 1.000 166 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(1), INPP1(2), INPP4A(5), INPP4B(2), INPP5A(4), INPPL1(15), ITPKB(6), MIOX(3), OCRL(4), PIK3C2A(6), PIK3C2B(13), PIK3C2G(43), PIK3CA(8), PIK3CB(21), PIK3CG(24), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PLCD1(3), PLCG1(9), PLCG2(25) 14902285 324 122 296 140 226 14 14 39 30 1 0.00633 1.000 1.000 167 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(5), ACTG2(4), ACTR2(3), ACTR3(2), AKT1(3), ANGPTL2(2), CDC42(2), CFL1(1), FLNA(15), FLNC(56), FSCN1(4), FSCN2(2), FSCN3(10), GDI1(1), GDI2(2), LIMK1(4), MYH2(77), MYLK(39), MYLK2(10), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), RHO(2), ROCK1(5), ROCK2(12), VASP(3), WASF1(4), WASL(5) 15936697 349 122 324 185 241 44 9 33 22 0 0.0356 1.000 1.000 168 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(8), CD28(1), CD3D(5), CSK(1), CTLA4(2), DAG1(5), EPHB2(29), FBXW7(11), GRAP2(4), GRB2(2), ITK(20), ITPKB(6), LAT(1), LCK(12), LCP2(9), MAPK1(4), NCK1(1), NFAT5(7), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PLCG1(9), PTPRC(30), RAF1(8), RASGRP1(7), RASGRP2(6), RASGRP3(13), RASGRP4(10), SOS1(8), SOS2(11), VAV1(15), ZAP70(7) 18516307 349 122 334 165 220 29 17 47 36 0 0.118 1.000 1.000 169 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), GUSB(3), UGDH(1), UGP2(1), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(6), UGT1A9(10), UGT2A1(18), UGT2A3(24), UGT2B10(36), UGT2B11(19), UGT2B15(25), UGT2B28(24), UGT2B4(31), UGT2B7(17), XYLB(4) 9088625 284 121 261 117 202 23 14 16 28 1 0.00361 1.000 1.000 170 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(9), ALOX12(5), ALOX12B(13), ALOX15(8), ALOX15B(8), ALOX5(8), CBR3(1), CYP2B6(16), CYP2C18(26), CYP2C19(35), CYP2C8(30), CYP2C9(35), CYP2E1(13), CYP2J2(5), CYP2U1(1), CYP4A11(23), CYP4A22(19), CYP4F2(12), CYP4F3(19), EPHX2(4), GGT1(6), GPX1(3), GPX3(3), GPX5(12), GPX6(15), LTA4H(4), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PTGDS(2), PTGES2(1), PTGIS(12), PTGS1(17), PTGS2(10), TBXAS1(11) 12915262 443 121 417 284 355 27 6 24 30 1 0.177 1.000 1.000 171 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 72 B2M(5), CALR(1), CANX(1), CD4(6), CD74(6), CD8A(2), CD8B(7), CIITA(15), CTSL1(1), CTSS(6), HLA-A(3), HLA-B(5), HLA-C(1), HLA-DMA(4), HLA-DMB(7), HLA-DOA(4), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(7), HLA-DQB1(5), HLA-DRA(11), HLA-DRB1(3), HLA-DRB5(1), HLA-E(1), HLA-F(6), HLA-G(3), HSP90AA1(2), HSP90AB1(5), HSPA5(5), IFI30(2), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(9), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(5), IFNA8(3), KIR2DL3(6), KIR2DL4(3), KIR2DS4(14), KIR3DL1(17), KIR3DL2(2), KIR3DL3(6), KLRC1(4), KLRC2(1), KLRC3(11), KLRC4(5), KLRD1(5), LGMN(5), LTA(2), NFYA(1), NFYB(3), NFYC(1), PDIA3(3), PSME2(4), RFX5(5), RFXANK(1), RFXAP(1), TAP1(1), TAP2(13), TAPBP(2) 15177385 294 121 285 175 193 27 12 33 29 0 0.531 1.000 1.000 172 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(3), AKT2(8), AKT3(4), BCR(10), BLNK(12), BTK(15), CD19(7), CSK(1), DAG1(5), EPHB2(29), GRB2(2), ITPKB(6), LYN(6), MAP2K1(10), MAP2K2(3), MAPK1(4), NFAT5(7), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PI3(6), PIK3CA(8), PIK3CD(7), PIK3R1(3), PLCG2(25), PPP1R13B(6), RAF1(8), SERPINA4(14), SHC1(1), SOS1(8), SOS2(11), SYK(14), VAV1(15) 17654407 279 120 267 148 173 21 15 41 28 1 0.429 1.000 1.000 173 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 52 ADH1A(14), ADH1B(27), ADH4(11), ADH6(11), ADH7(13), ADHFE1(5), AKR1A1(3), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH9A1(2), ALDOA(2), ALDOB(12), ALDOC(3), BPGM(2), DLAT(2), DLD(2), ENO1(4), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(5), GAPDH(1), GCK(17), GPI(3), HK1(3), HK2(12), HK3(13), LDHA(5), LDHB(2), LDHC(5), PDHA1(3), PDHA2(17), PDHB(1), PFKM(1), PGK1(4), PGM1(4), PGM3(1), PKLR(11), PKM2(5) 16073067 283 119 261 126 200 26 14 25 18 0 0.000539 1.000 1.000 174 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 52 ADH1A(14), ADH1B(27), ADH4(11), ADH6(11), ADH7(13), ADHFE1(5), AKR1A1(3), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH9A1(2), ALDOA(2), ALDOB(12), ALDOC(3), BPGM(2), DLAT(2), DLD(2), ENO1(4), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(5), GAPDH(1), GCK(17), GPI(3), HK1(3), HK2(12), HK3(13), LDHA(5), LDHB(2), LDHC(5), PDHA1(3), PDHA2(17), PDHB(1), PFKM(1), PGK1(4), PGM1(4), PGM3(1), PKLR(11), PKM2(5) 16073067 283 119 261 126 200 26 14 25 18 0 0.000539 1.000 1.000 175 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(5), AANAT(1), ABP1(18), ACAT2(1), ACMSD(10), AFMID(2), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), AOC2(7), AOC3(8), AOX1(21), ASMT(6), CARM1(6), CAT(5), CYP1A1(10), CYP1A2(10), CYP1B1(2), DDC(12), ECHS1(2), EHHADH(6), GCDH(5), HAAO(3), HADHA(8), HEMK1(4), HSD17B10(2), HSD17B4(6), INMT(8), KMO(8), KYNU(11), LCMT1(4), LNX1(17), MAOA(3), MAOB(13), METTL2B(7), METTL6(2), NFX1(6), OGDH(11), OGDHL(36), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), TDO2(5), TPH1(5), TPH2(12), WARS(4), WARS2(4), WBSCR22(1) 20221639 373 119 359 192 259 30 19 42 23 0 0.0975 1.000 1.000 176 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(48), B3GALT4(2), CDR1(12), DGKI(23), IL6ST(10), MRPL19(1), PIGK(6), RPL10(4), RPL11(2), RPL13A(2), RPL14(1), RPL15(2), RPL18(3), RPL18A(1), RPL19(1), RPL21(1), RPL22(2), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL38(1), RPL39(1), RPL3L(3), RPL4(5), RPL5(6), RPL6(1), RPL7(2), RPL7A(1), RPLP0(1), RPS10(1), RPS11(1), RPS13(1), RPS15(1), RPS16(1), RPS18(1), RPS2(2), RPS20(2), RPS23(1), RPS24(1), RPS27(1), RPS29(1), RPS3A(1), RPS5(1), RPS6(1), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KA6(15), RPS6KB1(2), RPS6KB2(3), RPS7(4), RPS8(1), RPSA(1), SLC36A2(7), TBC1D10C(5), TSPAN9(3), UBB(1), UBC(6) 17346050 233 119 223 135 144 22 13 32 22 0 0.712 1.000 1.000 177 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(8), F11(12), F12(1), F13B(23), F2(9), F5(30), F7(7), F8(42), F9(12), FGA(38), FGB(10), FGG(7), LPA(47), PLAT(3), PLAU(3), PLG(30), SERPINB2(16), SERPINE1(5), SERPINF2(6), VWF(49) 11731017 358 118 339 146 254 27 22 24 30 1 0.0135 1.000 1.000 178 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM10(7), ADAM17(1), ATP6AP1(2), ATP6V0A1(9), ATP6V0A2(4), ATP6V0A4(19), ATP6V0D2(8), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), CASP3(2), CDC42(2), CHUK(2), CSK(1), EGFR(22), F11R(5), GIT1(4), HBEGF(1), IGSF5(10), IKBKB(3), IL8(1), JAM2(10), JAM3(2), JUN(1), LYN(6), MAP2K4(4), MAP3K14(3), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK8(1), MAPK9(5), MET(19), NFKB1(7), NFKB2(4), NFKBIA(2), NOD1(6), PAK1(4), PLCG1(9), PLCG2(25), PTPN11(9), PTPRZ1(22), RELA(4), SRC(1), TCIRG1(3), TJP1(11) 23401565 317 118 312 194 199 28 16 46 28 0 0.904 1.000 1.000 179 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 22 ADRB1(5), AKT1(3), APC(19), CAMP(1), DAG1(5), DLG4(4), EPHB2(29), GNAI1(1), GNAQ(4), ITPR1(29), ITPR2(17), ITPR3(6), KCNJ3(18), KCNJ5(12), KCNJ9(4), MAPK1(4), PITX2(4), PTX3(1), RHO(2), RYR1(87) 15068624 255 118 246 169 176 25 12 19 23 0 0.620 1.000 1.000 180 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(12), BMPR1B(3), CCND2(5), CDK4(5), CDKN1B(1), DAZL(4), DMC1(10), EGR1(4), ESR2(6), FSHR(15), GJA4(4), INHA(4), LHCGR(24), MLH1(6), MSH5(14), NCOR1(19), NR5A1(7), NRIP1(8), PGR(15), PRLR(29), PTGER2(6), SMPD1(3), VDR(2), ZP2(13) 11659638 219 117 198 114 151 15 4 26 23 0 0.616 1.000 1.000 181 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(3), ATF2(5), CDC42(2), DLD(2), DUSP10(6), DUSP4(1), DUSP8(3), GAB1(4), GCK(17), IL1R1(11), JUN(1), MAP2K4(4), MAP2K5(3), MAP2K7(4), MAP3K1(2), MAP3K10(8), MAP3K11(6), MAP3K12(3), MAP3K13(10), MAP3K2(6), MAP3K3(6), MAP3K4(16), MAP3K5(16), MAP3K7(1), MAP3K9(22), MAPK10(8), MAPK7(4), MAPK8(1), MAPK9(5), MYEF2(4), NFATC3(9), NR2C2(2), PAPPA(50), SHC1(1), TRAF6(4), ZAK(6) 16528318 256 117 247 117 178 22 7 28 20 1 0.357 1.000 1.000 182 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 31 ABP1(18), ADH1A(14), ADH1B(27), ADH4(11), ADH6(11), ADH7(13), ADHFE1(5), ALDH1A3(2), ALDH3A1(5), ALDH3B1(2), ALDH3B2(7), AOC2(7), AOC3(8), AOX1(21), COMT(3), DBH(13), DCT(3), DDC(12), FAH(4), GOT1(6), GOT2(5), HGD(12), HPD(5), MAOA(3), MAOB(13), PNMT(4), TAT(17), TH(9), TPO(40), TYR(8) 10297601 308 117 290 154 237 22 17 17 15 0 0.00585 1.000 1.000 183 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(18), AGMAT(3), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH4A1(6), ALDH9A1(2), AOC2(7), AOC3(8), ARG1(1), ARG2(1), ASL(6), CKM(2), CKMT1A(1), CKMT2(5), CPS1(21), DAO(10), GAMT(4), GATM(5), GLUD1(2), GOT1(6), GOT2(5), MAOA(3), MAOB(13), NOS1(58), NOS3(16), OAT(3), ODC1(3), OTC(3), P4HA1(9), P4HA2(4), P4HA3(12), P4HB(2), PYCR1(1), RARS(7), SMS(5) 14710616 288 116 276 166 190 33 15 23 27 0 0.310 1.000 1.000 184 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CALM1(1), CALM2(1), CAMK1(4), CAMK1G(9), ELK1(2), FPR1(18), GNA15(5), HRAS(3), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K6(3), MAP3K1(2), MAPK1(4), MAPK14(5), MAPK3(1), NCF1(1), NCF2(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB1(7), NFKBIA(2), PAK1(4), PIK3C2G(43), PLCB1(48), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAF1(8), RELA(4), SYT1(19) 12577006 278 116 255 119 198 15 9 28 28 0 0.0302 1.000 1.000 185 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM2(1), DLG4(4), GRIN1(7), GRIN2A(86), GRIN2B(53), GRIN2C(8), GRIN2D(6), NOS1(58), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), SYT1(19) 8505068 286 116 268 181 213 28 5 19 21 0 0.332 1.000 1.000 186 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(9), ABP1(18), ACADL(4), ACADM(5), ACADSB(6), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2), AOC2(7), AOC3(8), CNDP1(8), DPYD(56), DPYS(22), ECHS1(2), EHHADH(6), GAD1(13), GAD2(7), HADHA(8), MLYCD(2), SDS(2), SMS(5), UPB1(6) 9726245 232 114 218 113 155 21 12 29 15 0 0.112 1.000 1.000 187 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(2), ALDOB(12), ALDOC(3), DLAT(2), DLD(2), ENO1(4), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(5), GAPDH(1), GAPDHS(1), GCK(17), GOT1(6), GOT2(5), GPI(3), HK1(3), HK2(12), HK3(13), LDHA(5), LDHAL6B(7), LDHB(2), LDHC(5), MDH1(1), MDH2(4), PC(12), PCK1(23), PDHA1(3), PDHA2(17), PDHB(1), PDHX(2), PFKL(4), PFKM(1), PGAM2(3), PGK1(4), PGK2(27), PKLR(11), PKM2(5), TNFAIP1(1) 14224075 241 113 226 117 175 18 12 20 16 0 0.00273 1.000 1.000 188 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(6), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPAT6(2), CDS1(9), CDS2(4), CHAT(14), CHKA(2), CHKB(3), CHPT1(1), CRLS1(1), DGKA(3), DGKB(22), DGKD(9), DGKE(6), DGKG(16), DGKH(8), DGKI(23), DGKQ(6), DGKZ(7), ESCO1(1), ESCO2(2), ETNK1(4), GNPAT(2), GPAM(5), GPD1(8), GPD1L(2), GPD2(2), LYPLA1(1), LYPLA2(1), MYST3(15), MYST4(14), NAT6(2), PCYT1A(3), PCYT1B(7), PEMT(2), PISD(2), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PLD1(11), PLD2(5), PNPLA3(2), PPAP2B(6), PPAP2C(8), PTDSS2(1), SH3GLB1(2) 21827869 325 113 310 183 211 29 9 42 34 0 0.630 1.000 1.000 189 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(46), C5(14), C6(56), C7(43), ICAM1(2), IL1A(4), IL6(2), IL8(1), ITGA4(36), ITGAL(24), ITGB1(4), ITGB2(13), SELP(30), SELPLG(8), TNF(1), VCAM1(16) 8229017 300 113 272 125 220 9 14 26 30 1 0.00185 1.000 1.000 190 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 12 C1QA(4), C1QB(3), C1R(13), C1S(15), C2(14), C3(46), C5(14), C6(56), C7(43), C8B(43), C9(19), MASP1(8) 6495952 278 112 247 126 210 14 9 27 17 1 0.0270 1.000 1.000 191 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B4GALT5(2), C1GALT1(6), C1GALT1C1(2), GALNT1(4), GALNT10(6), GALNT11(2), GALNT12(8), GALNT13(25), GALNT14(27), GALNT2(6), GALNT3(3), GALNT4(4), GALNT5(9), GALNT6(15), GALNT7(5), GALNT8(23), GALNT9(5), GALNTL1(4), GALNTL2(19), GALNTL4(6), GALNTL5(14), GCNT1(6), GCNT3(5), GCNT4(4), OGT(10), ST3GAL1(6), ST3GAL2(1), ST6GALNAC1(5), WBSCR17(37) 10798624 269 112 253 129 202 13 6 24 24 0 0.121 1.000 1.000 192 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 42 AKT1(3), AKT2(8), AKT3(4), CAB39(1), EIF4B(4), EIF4EBP1(1), FIGF(4), HIF1A(5), IGF1(11), MAPK1(4), MAPK3(1), PDPK1(4), PGF(1), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PRKAA1(1), PRKAA2(24), RHEB(1), RICTOR(10), RPS6(1), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KA6(15), RPS6KB1(2), RPS6KB2(3), STK11(3), TSC1(5), TSC2(11), ULK1(7), ULK2(6), ULK3(1), VEGFA(5), VEGFB(1) 16826415 245 112 231 110 144 17 11 47 24 2 0.164 1.000 1.000 193 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(15), CANT1(9), CDA(2), CTPS(2), CTPS2(3), DCTD(2), DHODH(3), DPYD(56), DPYS(22), ENTPD1(10), NT5E(4), NT5M(2), POLD1(6), POLD2(2), POLE(15), POLG(8), POLL(7), POLQ(23), POLR1B(8), POLR2A(11), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(2), RRM1(3), RRM2(2), TK2(1), TXNRD1(5), TYMS(1), UCK1(2), UMPS(1), UNG(3), UPB1(6) 19182339 257 112 241 115 164 23 11 36 23 0 0.0399 1.000 1.000 194 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(6), BAX(3), BCL2(2), BCL2L11(5), BIRC2(5), BIRC3(7), BIRC5(1), BNIP3L(2), CASP1(4), CASP10(4), CASP2(1), CASP3(2), CASP4(1), CASP7(4), CASP8(8), CASP9(3), CHUK(2), CYCS(1), DFFA(2), DFFB(3), FAS(5), FASLG(14), GZMB(3), HELLS(5), IKBKB(3), IRF1(1), IRF2(5), IRF3(3), IRF4(3), IRF5(4), IRF6(13), IRF7(7), JUN(1), LTA(2), MAP2K4(4), MAP3K1(2), MAPK10(8), MDM2(3), MYC(5), NFKB1(7), NFKBIA(2), NFKBIB(1), PLEKHG5(10), PRF1(11), RELA(4), RIPK1(1), TNF(1), TNFRSF10B(2), TNFRSF1A(3), TNFRSF1B(3), TNFRSF21(10), TNFRSF25(5), TNFSF10(7), TP73(5), TRAF1(6), TRAF2(2), TRAF3(5) 18830432 242 111 240 132 161 26 13 24 18 0 0.573 1.000 1.000 195 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(15), CALM1(1), CALM2(1), ELK1(2), FCER1A(12), FCER1G(1), FOS(2), GRB2(2), HRAS(3), JUN(1), LYN(6), MAP2K1(10), MAP2K4(4), MAP2K7(4), MAP3K1(2), MAPK1(4), MAPK3(1), MAPK8(1), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PAK2(8), PIK3CA(8), PIK3R1(3), PLA2G4A(11), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAF1(8), SHC1(1), SOS1(8), SYK(14), SYT1(19), VAV1(15) 14341253 233 111 221 106 152 12 12 34 22 1 0.349 1.000 1.000 196 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(9), ABP1(18), ACADM(5), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), AOC2(7), AOC3(8), CNDP1(8), DPYD(56), DPYS(22), ECHS1(2), EHHADH(6), GAD1(13), GAD2(7), HADHA(8), HIBCH(1), MLYCD(2), SMS(5), UPB1(6) 9047075 215 111 200 110 142 20 13 27 13 0 0.211 1.000 1.000 197 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(8), ALOX15(8), ALOX5(8), CYP1A2(10), CYP2C18(26), CYP2C19(35), CYP2C8(30), CYP2C9(35), CYP2E1(13), CYP2J2(5), CYP3A4(19), CYP3A43(15), CYP3A5(10), CYP3A7(18), HSD3B7(3), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), RDH11(2), RDH12(2), RDH13(3) 7978158 307 111 287 173 244 12 9 14 28 0 0.0428 1.000 1.000 198 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 13 C1QA(4), C1QB(3), C1R(13), C1S(15), C2(14), C3(46), C5(14), C6(56), C7(43), C9(19), MASP1(8), MASP2(9), MBL2(12) 6667902 256 110 229 116 194 12 5 25 19 1 0.0323 1.000 1.000 199 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(6), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPS(3), CDS1(9), CDS2(4), CHAT(14), CHKA(2), CHKB(3), CLC(3), CPT1B(10), DGKA(3), DGKB(22), DGKD(9), DGKE(6), DGKG(16), DGKH(8), DGKQ(6), DGKZ(7), ETNK1(4), GNPAT(2), GPD1(8), GPD2(2), LGALS13(4), LYPLA1(1), LYPLA2(1), PAFAH1B1(4), PAFAH2(2), PCYT1A(3), PCYT1B(7), PEMT(2), PISD(2), PLA2G1B(1), PLA2G2A(2), PLA2G2E(4), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PLCB2(9), PLCG1(9), PLCG2(25), PPAP2B(6), PPAP2C(8) 16691191 292 110 281 151 204 19 8 36 25 0 0.0666 1.000 1.000 200 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(8), B4GALT1(2), B4GALT2(2), G6PC(5), G6PC2(4), GAA(7), GALK1(1), GALK2(2), GALT(2), GANC(5), GCK(17), GLA(1), GLB1(8), HK1(3), HK2(12), HK3(13), HSD3B7(3), LALBA(7), LCT(40), MGAM(133), PFKL(4), PFKM(1), PGM1(4), PGM3(1), RDH11(2), RDH12(2), RDH13(3), UGP2(1) 12877943 295 110 279 162 216 27 7 29 16 0 0.0736 1.000 1.000 201 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(9), AKR1D1(17), ARSB(1), ARSD(3), ARSE(5), CYP11B1(13), CYP11B2(13), HSD11B1(11), HSD11B2(2), HSD17B2(9), HSD17B3(5), HSD3B1(10), HSD3B2(10), SRD5A1(2), SRD5A2(6), STS(7), SULT1E1(12), SULT2A1(7), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(6), UGT1A9(10), UGT2B15(25), UGT2B4(31) 9103797 277 109 257 129 187 29 16 16 28 1 0.00479 1.000 1.000 202 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(5), AGTR2(9), CALM1(1), CALM2(1), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CDK5(4), F2(9), FYN(6), GNA11(7), GNAI1(1), GRB2(2), HRAS(3), JAK2(9), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK14(5), MAPK3(1), MAPK8(1), MAPT(10), MYLK(39), PLCG1(9), PRKCA(10), PTK2B(10), RAF1(8), SHC1(1), SOS1(8), STAT1(4), STAT3(10), STAT5A(2), SYT1(19) 13854901 229 109 213 133 143 20 11 33 22 0 0.719 1.000 1.000 203 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(2), B4GALT2(2), FBP2(2), G6PC(5), GAA(7), GALK1(1), GALK2(2), GALT(2), GANAB(5), GCK(17), GLA(1), GLB1(8), HK1(3), HK2(12), HK3(13), LALBA(7), LCT(40), MGAM(133), PFKM(1), PGM1(4), PGM3(1) 10858696 270 108 254 145 198 27 7 25 13 0 0.0582 1.000 1.000 204 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 ACOX1(7), APOA1(2), CD36(4), CPT1B(10), CREBBP(20), EHHADH(6), EP300(14), FABP1(6), HSD17B4(6), JUN(1), LPL(3), MAPK1(4), MAPK3(1), ME1(19), MYC(5), NCOA1(9), NCOR1(19), NCOR2(24), NFKBIA(2), NR0B2(6), NR1H3(3), NR2F1(8), NRIP1(8), PDGFA(1), PIK3CA(8), PIK3R1(3), PPARA(6), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), PTGS2(10), RB1(8), RELA(4), RXRA(4), SP1(5), STAT5A(2), STAT5B(4), TNF(1) 21204376 275 107 267 127 178 20 18 32 24 3 0.192 1.000 1.000 205 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 47 AKT1(3), AKT2(8), AKT3(4), BRD4(19), CAP1(1), CBL(8), CDC42(2), F2RL2(6), FLOT1(2), GRB2(2), GSK3B(2), IGFBP1(3), INPPL1(15), IRS1(5), IRS2(2), IRS4(12), LNPEP(10), MAPK1(4), MAPK3(1), PARD3(15), PARD6A(1), PDK1(2), PIK3CA(8), PIK3CD(7), PIK3R1(3), PPYR1(12), PTPN1(4), RAF1(8), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KB1(2), SERPINB6(4), SFN(1), SHC1(1), SLC2A4(8), SORBS1(13), SOS1(8), SOS2(11), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3) 19483227 238 106 235 119 132 27 13 40 25 1 0.563 1.000 1.000 206 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 AKT1(3), APC(19), AR(7), CAMP(1), CCL15(3), CCL16(1), DAG1(5), EGFR(22), GNA11(7), GNA15(5), GNAI1(1), GNAQ(4), ITPKB(6), ITPR1(29), ITPR2(17), ITPR3(6), KCNJ3(18), KCNJ5(12), KCNJ9(4), MAPK1(4), MAPK10(8), MAPK14(5), PHKA2(7), PIK3CA(8), PIK3CD(7), PIK3R1(3), PITX2(4), PTX3(1), RAF1(8), SRC(1) 17231824 226 106 218 137 139 19 13 28 26 1 0.765 1.000 1.000 207 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 41 AKT1(3), ATF1(4), CAMP(1), CREB3(1), CREB5(9), CREBBP(20), CRKL(2), DAG1(5), EGR1(4), EGR2(4), EGR3(2), EGR4(5), ELK1(2), FRS2(4), GNAQ(4), JUN(1), MAP1B(21), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK3(1), MAPK8(1), MAPK8IP1(4), MAPK8IP2(7), MAPK8IP3(8), MAPK9(5), NTRK1(15), OPN1LW(4), PIK3C2G(43), PIK3CA(8), PIK3CD(7), PIK3R1(3), PTPN11(9), RPS6KA3(2), SHC1(1), SRC(1), TERF2IP(1), TH(9) 16570309 241 106 231 119 162 17 8 30 23 1 0.307 1.000 1.000 208 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(3), AKT2(8), AKT3(4), ARHGEF11(17), BCL2(2), CDC42(2), DLG4(4), GNA13(1), LPA(47), MAP2K4(4), MAP3K1(2), MAP3K5(16), MAPK8(1), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PDK1(2), PHKA2(7), PI3(6), PIK3CB(21), PLD1(11), PLD2(5), PLD3(1), PTK2(8), RDX(1), ROCK1(5), ROCK2(12), SERPINA4(14), SRF(2), TBXA2R(4) 16383940 231 106 220 122 128 19 10 45 29 0 0.741 1.000 1.000 209 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(56), GABBR1(7), GPRC5A(4), GPRC5B(5), GPRC5C(8), GPRC5D(2), GRM1(16), GRM2(7), GRM3(49), GRM4(19), GRM5(13), GRM7(32), GRM8(43) 6981213 261 105 243 183 192 18 12 23 16 0 0.227 1.000 1.000 210 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 37 ACAA1(5), ACAA2(1), ACAD8(1), ACAD9(1), ADH1A(14), ADH1B(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), AKR1B10(8), AKR1C4(9), AKR1D1(17), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), BAAT(10), CEL(11), CYP27A1(4), CYP7A1(8), HADHB(4), HSD3B7(3), LIPA(4), RDH11(2), RDH12(2), RDH13(3), SLC27A5(6), SOAT1(3), SOAT2(6), SRD5A1(2), SRD5A2(6) 10365796 232 105 213 112 153 24 19 19 17 0 0.0291 1.000 1.000 211 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(7), AADAC(14), ABAT(9), ACADS(4), ACAT2(1), ACSM1(25), AKR1B10(8), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH5A1(10), ALDH7A1(9), ALDH9A1(2), BDH1(5), DDHD1(6), ECHS1(2), EHHADH(6), GAD1(13), GAD2(7), HADHA(8), HMGCL(4), HMGCS1(2), HMGCS2(17), HSD17B10(2), HSD17B4(6), HSD3B7(3), ILVBL(4), L2HGDH(3), OXCT1(4), OXCT2(3), PDHA1(3), PDHA2(17), PDHB(1), PLA1A(9), PPME1(1), PRDX6(4), RDH11(2), RDH12(2), RDH13(3) 13600875 247 105 238 123 168 25 13 22 19 0 0.104 1.000 1.000 212 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(3), AKT2(8), AKT3(4), ANKRD6(3), APC(19), AXIN1(10), AXIN2(3), CER1(12), CSNK1A1(2), CTNNB1(11), DACT1(10), DKK1(2), DKK2(14), DKK3(4), DKK4(3), FSTL1(2), GSK3B(2), LRP1(31), MVP(10), NKD1(8), NKD2(5), PIN1(1), PSEN1(1), PTPRA(7), SENP2(11), SFRP1(2), TSHB(6), WIF1(7) 13354987 201 105 197 105 117 25 8 26 25 0 0.520 1.000 1.000 213 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(10), CFL1(1), GNAQ(4), GNAS(19), HRAS(3), LIMK1(4), MAP2K1(10), MAPK1(4), MAPK3(1), MYL2(5), NOX1(11), PIK3C2G(43), PLCB1(48), PPP1R12B(8), PRKCA(10), PTK2(8), RAF1(8), ROCK2(12) 8368659 210 104 191 83 150 7 5 31 17 0 0.0417 1.000 1.000 214 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 10 C1QA(4), C1QB(3), C1R(13), C1S(15), C2(14), C3(46), C5(14), C6(56), C7(43), C9(19) 5393512 227 104 202 102 170 10 5 24 17 1 0.0478 1.000 1.000 215 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(5), AASDHPPT(3), AASS(3), ACAT2(1), AKR1B10(8), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), BBOX1(4), DOT1L(8), ECHS1(2), EHHADH(6), EHMT1(7), EHMT2(9), GCDH(5), HADHA(8), HSD17B10(2), HSD17B4(6), HSD3B7(3), NSD1(16), OGDH(11), OGDHL(36), PIPOX(5), PLOD1(5), PLOD2(6), PLOD3(4), RDH11(2), RDH12(2), RDH13(3), SETD1A(23), SETD7(2), SETDB1(10), SHMT1(1), SHMT2(2), SUV39H1(1), SUV39H2(1), TMLHE(1) 19334304 243 104 234 115 157 22 14 33 17 0 0.120 1.000 1.000 216 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 41 CALM1(1), CALM2(1), CD3D(5), CD3E(2), CD3G(1), ELK1(2), FOS(2), FYN(6), GRB2(2), HRAS(3), JUN(1), LAT(1), LCK(12), MAP2K1(10), MAP2K4(4), MAP3K1(2), MAPK3(1), MAPK8(1), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB1(7), NFKBIA(2), PIK3CA(8), PIK3R1(3), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(10), PTPN7(2), RAF1(8), RASA1(4), RELA(4), SHC1(1), SOS1(8), SYT1(19), VAV1(15), ZAP70(7) 15798783 221 104 210 100 143 20 8 30 19 1 0.313 1.000 1.000 217 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(21), ACACB(17), ACAT2(1), ACOT12(12), ACSS1(1), ACSS2(4), AKR1B1(2), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(2), LDHA(5), LDHAL6A(4), LDHAL6B(7), LDHB(2), LDHC(5), LDHD(1), MDH1(1), MDH2(4), ME1(19), ME2(1), ME3(9), PC(12), PCK1(23), PCK2(4), PDHA1(3), PDHA2(17), PDHB(1), PKLR(11), PKM2(5) 15671151 233 103 224 124 151 18 15 32 17 0 0.265 1.000 1.000 218 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 34 ACTA1(4), CRK(2), CRKL(2), DOCK1(15), ELK1(2), FOS(2), GAB1(4), GRB2(2), HGF(23), HRAS(3), ITGA1(18), ITGB1(4), JUN(1), MAP2K1(10), MAP2K2(3), MAP4K1(9), MAPK1(4), MAPK3(1), MAPK8(1), MET(19), PAK1(4), PIK3CA(8), PIK3R1(3), PTK2(8), PTK2B(10), PTPN11(9), PXN(3), RAF1(8), RAP1A(2), RAP1B(1), RASA1(4), SOS1(8), SRC(1), STAT3(10) 14338261 208 103 196 103 129 16 7 34 21 1 0.706 1.000 1.000 219 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(5), APAF1(6), ARHGDIB(3), BAG4(3), BCL2(2), BIRC2(5), BIRC3(7), CASP2(1), CASP3(2), CASP7(4), CASP8(8), CASP9(3), CFLAR(4), CHUK(2), CRADD(1), CYCS(1), DAXX(9), DFFA(2), DFFB(3), GSN(6), LMNA(8), LMNB1(2), LMNB2(4), MAP2K7(4), MAP3K1(2), MAP3K14(3), MAP3K5(16), MAPK8(1), MDM2(3), NFKB1(7), NFKBIA(2), NUMA1(8), PAK2(8), PRKCD(4), PRKDC(18), PSEN1(1), PSEN2(2), PTK2(8), RASA1(4), RB1(8), RELA(4), RIPK1(1), SPTAN1(7), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF1(6), TRAF2(2) 23135081 217 102 214 100 104 26 14 47 24 2 0.333 1.000 1.000 220 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(24), ATP4A(15), ATP4B(1), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(6), ATP5G2(1), ATP5H(1), ATP5J(2), ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A2(4), ATP6V0A4(19), ATP6V0D2(8), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), COX10(5), COX15(4), COX4I2(4), COX5B(1), COX6A1(1), COX6B1(1), COX6C(1), COX7B(1), COX7B2(2), COX8A(1), COX8C(1), CYC1(4), LHPP(1), NDUFA10(2), NDUFA12(1), NDUFA13(6), NDUFA4(1), NDUFA6(1), NDUFA9(2), NDUFAB1(1), NDUFB2(3), NDUFB3(1), NDUFB5(3), NDUFB6(2), NDUFC2(1), NDUFS2(2), NDUFS3(3), NDUFS4(3), NDUFS5(1), NDUFS6(2), NDUFS7(3), NDUFS8(3), NDUFV1(2), PPA1(1), PPA2(3), SDHA(1), SDHB(1), SDHC(2), SDHD(1), TCIRG1(3), UQCRC1(3), UQCRC2(2), UQCRFS1(2) 18756500 227 102 220 107 135 20 15 35 22 0 0.112 1.000 1.000 221 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(3), ACTR3(2), AKT1(3), ANGPTL2(2), DAG1(5), DGKA(3), ETFA(2), GCA(3), ITGA9(13), ITPKB(6), ITPR1(29), ITPR2(17), ITPR3(6), MAP2K1(10), MAPK1(4), MAPK3(1), NR1I3(7), PAK1(4), PDE3A(24), PDE3B(6), PI3(6), PIK3C2G(43), PIK3CA(8), PIK3CD(7), PIK3R1(3), RIPK3(11), VASP(3) 16198453 231 102 214 93 160 18 10 22 20 1 0.00105 1.000 1.000 222 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(2), CHUK(2), DAXX(9), EGF(18), EGFR(22), ETS1(4), ETS2(8), FOS(2), HOXA7(2), HRAS(3), IKBKB(3), JUN(1), MAP2K1(10), MAP2K3(7), MAP2K4(4), MAP2K6(3), MAP2K7(4), MAP3K1(2), MAP3K14(3), MAP3K5(16), MAPK1(4), MAPK13(4), MAPK14(5), MAPK3(1), MAPK8(1), NFKB1(7), NFKBIA(2), PPP2CA(1), PRKCA(10), PRKCD(4), PRKCE(6), PRKCG(13), PRKCH(10), PRKCQ(16), RAF1(8), RELA(4), RIPK1(1), SP1(5), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF2(2) 16355749 236 101 227 147 148 20 9 37 22 0 0.933 1.000 1.000 223 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(7), EIF2B1(9), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(1), EIF2S1(1), ELAVL1(1), FLT1(33), FLT4(23), HIF1A(5), HRAS(3), KDR(42), NOS3(16), PIK3CA(8), PIK3R1(3), PLCG1(9), PRKCA(10), PTK2(8), PXN(3), SHC1(1), VHL(4) 11418226 192 101 177 98 122 16 3 25 25 1 0.447 1.000 1.000 224 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BLNK(12), BTK(15), CALM1(1), CALM2(1), CD79A(2), CD79B(1), ELK1(2), FOS(2), GRB2(2), HRAS(3), JUN(1), LYN(6), MAP2K1(10), MAP3K1(2), MAPK14(5), MAPK3(1), MAPK8(1), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(10), RAF1(8), SHC1(1), SOS1(8), SYK(14), SYT1(19), VAV1(15) 12631923 208 100 197 96 139 10 10 28 21 0 0.313 1.000 1.000 225 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(8), ALPL(9), ALPP(9), ALPPL2(11), ASCC3(10), ATP13A2(9), DDX18(4), DDX19A(1), DDX23(5), DDX4(11), DDX41(6), DDX47(1), DDX50(4), DDX51(5), DDX52(3), DDX54(2), DDX55(3), DDX56(3), DHX58(4), ENTPD7(2), EP400(22), ERCC2(2), ERCC3(4), FPGS(3), GGH(2), IFIH1(13), MOV10L1(26), NUDT5(2), NUDT8(1), QDPR(3), RAD54B(6), RUVBL2(4), SETX(17), SKIV2L2(4), SMARCA2(11), SMARCA5(5), SPR(2) 20864780 237 100 226 121 153 15 12 31 26 0 0.377 1.000 1.000 226 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 59 A4GALT(5), ABO(5), B3GALNT1(6), B3GALT1(11), B3GALT2(1), B3GALT4(2), B3GALT5(1), B3GNT1(2), B3GNT2(2), B3GNT3(6), B3GNT4(3), B3GNT5(1), B4GALNT1(3), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), B4GALT6(1), FUT1(3), FUT2(3), FUT3(4), FUT4(2), FUT5(6), FUT6(4), FUT7(2), GBGT1(2), PIGA(2), PIGB(4), PIGC(3), PIGF(2), PIGG(10), PIGH(1), PIGK(6), PIGL(2), PIGM(2), PIGN(3), PIGO(12), PIGQ(8), PIGS(1), PIGT(1), PIGU(6), PIGV(7), PIGX(2), PIGZ(3), ST3GAL1(6), ST3GAL2(1), ST3GAL3(1), ST3GAL4(1), ST3GAL5(2), ST3GAL6(2), ST6GALNAC3(5), ST6GALNAC4(1), ST6GALNAC5(7), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(9), UGCG(1) 15943455 198 100 195 114 115 21 11 27 24 0 0.445 1.000 1.000 227 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(27), AR(7), ESR1(5), ESR2(6), ESRRA(2), HNF4A(18), NPM1(3), NR0B1(2), NR1D2(9), NR1H2(3), NR1H3(3), NR1I2(3), NR1I3(7), NR2C2(2), NR2E1(4), NR2F1(8), NR2F2(1), NR2F6(1), NR3C1(7), NR4A1(3), NR4A2(3), NR5A1(7), NR5A2(18), PGR(15), PPARA(6), PPARD(3), PPARG(11), RARA(3), RARB(5), RARG(2), ROR1(10), RORA(4), RORC(7), RXRA(4), RXRB(4), RXRG(5), THRA(2), THRB(14), VDR(2) 13923535 246 100 236 126 180 19 4 24 19 0 0.0944 1.000 1.000 228 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 26 ACAA1(5), ACAA2(1), ADH1A(14), ADH1B(27), ADH4(11), ADH6(11), ADH7(13), ADHFE1(5), AKR1C4(9), AKR1D1(17), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2), BAAT(10), CEL(11), CYP27A1(4), CYP7A1(8), HADHB(4), SOAT2(6), SRD5A1(2), SRD5A2(6) 7543482 202 99 185 89 134 20 14 18 16 0 0.0106 1.000 1.000 229 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(6), ARG1(1), ARG2(1), ASL(6), ASS1(7), CKM(2), CKMT1A(1), CKMT2(5), CPS1(21), DAO(10), EPRS(9), GAMT(4), GATM(5), GLUD1(2), GLUD2(4), GOT1(6), GOT2(5), LAP3(1), NOS1(58), NOS3(16), OAT(3), OTC(3), P4HA1(9), P4HA2(4), P4HA3(12), PRODH(1), PYCR1(1), PYCR2(1), RARS(7), RARS2(2) 11969795 213 99 203 119 146 22 8 16 21 0 0.321 1.000 1.000 230 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(18), ACY3(3), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH7A1(9), ALDH9A1(2), AMDHD1(4), AOC2(7), AOC3(8), ASPA(3), CARM1(6), CNDP1(8), DDC(12), FTCD(2), HAL(12), HARS(6), HARS2(4), HDC(19), HEMK1(4), HNMT(1), LCMT1(4), MAOA(3), MAOB(13), METTL2B(7), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), PRPS1(2), PRPS2(3), UROC1(11), WBSCR22(1) 13210690 228 99 222 147 150 24 14 21 19 0 0.666 1.000 1.000 231 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(8), ADRA1B(3), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(2), CHRM1(5), CHRM2(18), CHRM3(19), CHRM4(6), CHRM5(4), DRD1(8), DRD2(15), DRD3(5), DRD4(1), DRD5(22), HRH1(14), HRH2(3), HTR1A(8), HTR1B(1), HTR1D(3), HTR1E(5), HTR1F(7), HTR2A(8), HTR2B(2), HTR2C(10), HTR4(9), HTR5A(16), HTR6(1), HTR7(8) 8419362 225 99 209 172 147 25 7 25 21 0 0.107 1.000 1.000 232 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(9), ALOX12(5), ALOX15(8), ALOX5(8), CBR3(1), CYP4F2(12), CYP4F3(19), EPX(7), GGT1(6), LPO(18), LTA4H(4), MPO(11), PLA2G1B(1), PLA2G2A(2), PLA2G2E(4), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PRDX1(2), PRDX2(2), PRDX6(4), PTGDS(2), PTGES2(1), PTGIS(12), PTGS1(17), PTGS2(10), TBXAS1(11), TPO(40) 9318845 253 99 247 149 192 22 3 19 17 0 0.0899 1.000 1.000 233 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(3), ADRBK2(4), ARRB2(6), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CLCA1(6), CLCA2(9), CLCA4(26), CNGA3(24), CNGA4(14), CNGB1(20), GNAL(2), GUCA1A(5), GUCA1B(2), GUCA1C(6), PDC(5), PDE1C(41), PRKACA(3), PRKACB(4), PRKACG(8), PRKG1(12), PRKG2(13), PRKX(3) 10082431 242 98 229 141 168 20 7 28 19 0 0.396 1.000 1.000 234 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(5), AARS2(2), CARS(9), CARS2(2), DARS(4), DARS2(3), EPRS(9), FARS2(4), FARSA(6), FARSB(5), GARS(6), HARS(6), HARS2(4), IARS(8), IARS2(13), KARS(4), LARS(10), LARS2(4), MARS(6), MARS2(4), MTFMT(2), NARS(2), NARS2(5), QARS(6), RARS(7), RARS2(2), SARS(10), SARS2(3), TARS(2), TARS2(7), VARS(18), VARS2(6), WARS(4), WARS2(4), YARS(1), YARS2(2) 18319729 195 97 182 97 119 21 9 25 21 0 0.385 1.000 1.000 235 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(5), CHUK(2), ELK1(2), FOS(2), IKBKB(3), IRAK1(4), JUN(1), LY96(4), MAP2K3(7), MAP2K4(4), MAP2K6(3), MAP3K1(2), MAP3K14(3), MAP3K7(1), MAPK14(5), MAPK8(1), MYD88(3), NFKB1(7), NFKBIA(2), PPARA(6), RELA(4), TIRAP(1), TLR10(11), TLR2(15), TLR3(9), TLR4(31), TLR6(5), TLR7(15), TLR9(14), TOLLIP(1), TRAF6(4) 12116932 177 97 174 88 114 17 9 23 14 0 0.261 1.000 1.000 236 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(9), ACAA1(5), ACAA2(1), ACADM(5), ACADS(4), ACAT2(1), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH6A1(3), ALDH7A1(9), ALDH9A1(2), AOX1(21), AUH(3), BCAT1(11), BCAT2(1), BCKDHA(1), BCKDHB(2), DBT(1), DLD(2), ECHS1(2), EHHADH(6), HADHA(8), HADHB(4), HIBADH(8), HIBCH(1), HMGCL(4), HMGCS1(2), HMGCS2(17), HSD17B10(2), HSD17B4(6), IVD(4), MCCC1(5), MCCC2(2), MCEE(2), MUT(5), OXCT1(4), OXCT2(3), PCCA(3), PCCB(2) 14450538 192 96 184 95 119 19 12 29 13 0 0.459 1.000 1.000 237 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(21), ACAT2(1), ADH5(3), AKR1B1(2), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(2), LDHA(5), LDHB(2), LDHC(5), LDHD(1), MDH1(1), MDH2(4), ME1(19), ME2(1), ME3(9), PC(12), PCK1(23), PDHA1(3), PDHA2(17), PDHB(1), PKLR(11), PKM2(5) 12386901 193 96 187 105 131 16 10 24 12 0 0.423 1.000 1.000 238 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(15), DLG4(4), EPHB2(29), F2(9), F2RL1(15), F2RL2(6), F2RL3(3), JUN(1), MAP2K5(3), MAPK1(4), MAPK7(4), MAPK8(1), MYEF2(4), PLD1(11), PLD2(5), PLD3(1), PTK2(8), RAF1(8), RASAL1(15), SRC(1), TEC(10), VAV1(15) 9149425 172 96 164 106 97 18 6 35 16 0 0.854 1.000 1.000 239 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 36 ABP1(18), AGXT(10), ALAS1(1), ALAS2(5), AMT(1), AOC2(7), AOC3(8), BHMT(8), CBS(6), CHDH(7), CHKA(2), CHKB(3), CPT1B(10), CTH(1), DAO(10), DLD(2), DMGDH(12), GAMT(4), GARS(6), GATM(5), GCAT(4), GLDC(4), MAOA(3), MAOB(13), PEMT(2), PISD(2), PLCB2(9), PLCG1(9), PLCG2(25), PSPH(2), SARDH(19), SARS(10), SHMT1(1), SHMT2(2), TARS(2) 13731892 233 95 227 135 161 17 14 22 19 0 0.263 1.000 1.000 240 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(4), ACTN1(5), ACTN2(21), ACTN3(7), BCAR1(4), BCR(10), CAPN1(4), CAPNS1(1), CAV1(1), CRKL(2), CSK(1), FYN(6), GRB2(2), HRAS(3), ITGA1(18), ITGB1(4), JUN(1), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), MAPK8(1), PPP1R12B(8), PTK2(8), PXN(3), RAF1(8), RAP1A(2), ROCK1(5), SHC1(1), SOS1(8), SRC(1), TLN1(12), VCL(7), ZYX(6) 15599260 182 95 174 90 104 20 8 29 20 1 0.256 1.000 1.000 241 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 5 C3(46), C5(14), C6(56), C7(43), C9(19) 3766498 178 94 157 76 136 5 4 17 15 1 0.0572 1.000 1.000 242 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(18), ALDH1A3(2), ALDH3A1(5), ALDH3B1(2), ALDH3B2(7), AOC2(7), AOC3(8), DDC(12), EPX(7), ESCO1(1), ESCO2(2), GOT1(6), GOT2(5), HPD(5), LPO(18), MAOA(3), MAOB(13), MPO(11), MYST3(15), MYST4(14), NAT6(2), PNPLA3(2), PRDX6(4), SH3GLB1(2), TAT(17), TPO(40) 11460378 228 94 222 146 167 21 10 17 13 0 0.744 1.000 1.000 243 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(3), ARSE(5), B4GALT6(1), CERK(1), DEGS1(1), DEGS2(4), ENPP7(6), GAL3ST1(8), GALC(3), GBA(3), GLA(1), GLB1(8), LCT(40), NEU1(7), NEU2(14), NEU3(3), NEU4(9), PPAP2B(6), PPAP2C(8), SGMS1(15), SGMS2(1), SGPP2(6), SMPD1(3), SMPD2(1), SMPD3(8), SMPD4(5), SPHK1(1), SPHK2(7), SPTLC1(1), SPTLC2(6), UGCG(1), UGT8(7) 11837746 193 94 187 123 136 14 5 23 15 0 0.757 1.000 1.000 244 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 ARFIP2(1), CDK5(4), CFL1(1), CHN1(5), LIMK1(4), MAP3K1(2), MYL2(5), MYLK(39), NCF2(7), PAK1(4), PDGFRA(27), PIK3CA(8), PIK3R1(3), PLD1(11), PPP1R12B(8), RALBP1(2), RPS6KB1(2), TRIO(18), VAV1(15), WASF1(4) 11572854 170 94 163 100 112 10 9 21 17 1 0.840 1.000 1.000 245 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(9), F2R(6), F2RL3(3), GNAI1(1), HRAS(3), ITGA1(18), ITGB1(4), MAP2K1(10), MAPK1(4), MAPK3(1), PLA2G4A(11), PLCB1(48), PRKCA(10), PTGS1(17), PTK2(8), RAF1(8), SRC(1), SYK(14), TBXAS1(11) 8136189 187 94 173 87 131 13 5 20 18 0 0.131 1.000 1.000 246 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(5), ACAA2(1), ACADL(4), ACADM(5), ACADS(4), ACADSB(6), ACAT2(1), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH6A1(3), ALDH9A1(2), AOX1(21), BCAT1(11), BCKDHA(1), BCKDHB(2), ECHS1(2), EHHADH(6), HADHA(8), HADHB(4), HIBADH(8), HMGCL(4), IVD(4), MCCC1(5), MCCC2(2), MCEE(2), MUT(5), OXCT1(4), PCCA(3), PCCB(2), SDS(2) 12098840 163 94 157 83 103 15 8 23 14 0 0.526 1.000 1.000 247 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(1), EGFR(22), ELK1(2), GNAS(19), GRB2(2), HRAS(3), IGF1R(10), ITGB1(4), KLK2(2), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), MKNK1(5), MKNK2(2), MYC(5), NGFR(7), PDGFRA(27), PPP2CA(1), PTPRR(24), RAF1(8), RPS6KA1(6), RPS6KA5(4), SHC1(1), SOS1(8), SRC(1), STAT3(10) 10987139 192 93 182 99 124 17 9 29 13 0 0.452 1.000 1.000 248 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(3), APC(19), AXIN1(10), CCND1(1), CD14(5), CTNNB1(11), FZD1(4), GJA1(7), GNAI1(1), GSK3B(2), IRAK1(4), LBP(8), LEF1(3), LY96(4), MYD88(3), NFKB1(7), PDPK1(4), PIK3CA(8), PIK3R1(3), PPP2CA(1), RELA(4), TIRAP(1), TLR4(31), TOLLIP(1), WNT1(2) 10153763 147 93 142 74 89 11 9 19 18 1 0.576 1.000 1.000 249 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(2), ALG10(4), ALG10B(4), ALG12(1), ALG13(8), ALG14(2), ALG2(4), ALG3(4), ALG5(2), ALG6(2), ALG8(6), ALG9(5), B4GALT1(2), B4GALT2(2), B4GALT3(2), DAD1(1), DDOST(2), DHDDS(1), DOLPP1(3), DPAGT1(2), DPM1(1), FUT8(8), GANAB(5), MAN1A1(15), MAN1A2(4), MAN1B1(4), MAN1C1(7), MAN2A1(10), MGAT1(3), MGAT2(2), MGAT3(10), MGAT4A(8), MGAT4B(1), MGAT5(4), MGAT5B(9), RFT1(3), RPN2(2), ST6GAL1(5), STT3B(5) 14155561 165 93 161 90 100 17 11 18 19 0 0.426 1.000 1.000 250 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(3), ACTR3(2), ARHGAP1(2), ARHGAP4(2), ARHGAP5(11), ARHGAP6(11), ARHGEF1(1), ARHGEF11(17), ARHGEF5(15), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), BAIAP2(5), CFL1(1), DIAPH1(6), GSN(6), LIMK1(4), MYL2(5), MYLK(39), OPHN1(4), PIP5K1A(6), PIP5K1B(18), PPP1R12B(8), ROCK1(5), SRC(1), TLN1(12), VCL(7) 15047378 197 93 190 94 138 13 7 25 14 0 0.0703 1.000 1.000 251 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 23 ATF2(5), BCR(10), BLNK(12), ELK1(2), FOS(2), GRB2(2), HRAS(3), JUN(1), LYN(6), MAP2K1(10), MAP3K1(2), MAPK1(4), MAPK3(1), MAPK8IP3(8), PAPPA(50), RPS6KA1(6), RPS6KA3(2), SHC1(1), SOS1(8), SYK(14), VAV1(15), VAV2(3), VAV3(9) 10492583 176 93 164 112 125 12 3 18 17 1 0.898 1.000 1.000 252 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(2), APC(19), ATF2(5), AXIN1(10), BMP10(13), BMP2(4), BMP4(3), BMP5(25), BMP7(2), BMPR1A(2), BMPR2(5), CHRD(14), CTNNB1(11), FZD1(4), GATA4(2), GSK3B(2), MAP3K7(1), MEF2C(2), MYL2(5), NKX2-5(1), NOG(1), NPPA(3), NPPB(5), RFC1(5), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(7), TGFBR3(6), WNT1(2) 12084133 166 92 157 84 110 15 6 16 19 0 0.628 1.000 1.000 253 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(26), CALM1(1), CALM2(1), ELK1(2), FOS(2), GNAI1(1), GNAQ(4), GNAS(19), HRAS(3), JUN(1), MAP2K1(10), MAPK3(1), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), RAF1(8), RPS6KA3(2), SYT1(19) 11605364 198 92 186 113 131 15 10 23 19 0 0.777 1.000 1.000 254 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 32 AARS(5), AARS2(2), ABAT(9), ACY3(3), ADSL(6), ADSS(2), ADSSL1(8), AGXT(10), ASL(6), ASNS(8), ASPA(3), ASRGL1(3), ASS1(7), CAD(15), CRAT(5), DARS(4), DARS2(3), DDO(7), DLAT(2), DLD(2), GAD1(13), GAD2(7), GOT1(6), GOT2(5), GPT(3), GPT2(1), NARS(2), NARS2(5), PC(12), PDHA1(3), PDHA2(17), PDHB(1) 12353931 185 92 179 96 129 19 9 19 9 0 0.157 1.000 1.000 255 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(4), CR1(53), CR2(32), FCGR2B(3), HLA-DRA(11), HLA-DRB1(3), ICAM1(2), ITGAL(24), ITGB2(13), PTPRC(30) 5023253 175 91 168 68 116 15 5 15 24 0 0.0339 1.000 1.000 256 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 44 ABP1(18), AGXT(10), AKR1B10(8), ALAS1(1), ALAS2(5), AMT(1), AOC2(7), AOC3(8), BHMT(8), CBS(6), CHDH(7), CHKA(2), CHKB(3), CTH(1), DAO(10), DLD(2), DMGDH(12), GAMT(4), GARS(6), GATM(5), GCAT(4), GLDC(4), GNMT(1), HSD3B7(3), MAOA(3), MAOB(13), PEMT(2), PHGDH(13), PIPOX(5), PISD(2), PSAT1(2), PSPH(2), RDH11(2), RDH12(2), RDH13(3), SARDH(19), SARS(10), SARS2(3), SDS(2), SHMT1(1), SHMT2(2), TARS(2), TARS2(7) 13963335 231 91 221 134 153 17 12 24 25 0 0.388 1.000 1.000 257 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(5), BLVRA(2), BLVRB(1), CP(11), CPOX(4), EPRS(9), FECH(3), GUSB(3), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), PPOX(3), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(6), UGT1A9(10), UGT2B15(25), UGT2B4(31), UROS(1) 9248770 182 91 172 89 120 18 12 11 20 1 0.183 1.000 1.000 258 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(8), EGF(18), EGFR(22), GRB2(2), HRAS(3), MAP2K1(10), MAPK1(4), MAPK3(1), PTPRB(79), RAF1(8), RASA1(4), SHC1(1), SOS1(8), SPRY1(7), SPRY2(4), SPRY3(11), SPRY4(1), SRC(1) 8348128 192 91 176 86 137 16 6 19 14 0 0.271 1.000 1.000 259 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(6), BAX(3), BCL2(2), BCL2A1(1), BCL2L2(2), CASP1(4), CASP10(4), CASP2(1), CASP3(2), CASP4(1), CASP7(4), CASP8(8), CASP9(3), CD40(4), CD40LG(2), CRADD(1), CYCS(1), DAXX(9), DFFA(2), DFFB(3), FAS(5), FASLG(14), IKBKE(9), LTA(2), MCL1(3), NFKB1(7), NFKBIA(2), NGFR(7), NR3C1(7), NTRK1(15), PTPN13(12), RIPK1(1), SFRS2IP(7), TFG(2), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF1(6), TRAF2(2), TRAF3(5), TRAF6(4) 14484803 180 90 179 99 113 15 9 22 21 0 0.757 1.000 1.000 260 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(18), ALDH1A3(2), ALDH3A1(5), ALDH3B1(2), ALDH3B2(7), AOC2(7), AOC3(8), DDC(12), EPX(7), GOT1(6), GOT2(5), HPD(5), LPO(18), MAOA(3), MAOB(13), MPO(11), PRDX1(2), PRDX2(2), PRDX6(4), TAT(17), TPO(40) 7324905 194 90 189 118 147 17 9 10 11 0 0.148 1.000 1.000 261 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(4), ANXA2(2), ANXA3(4), ANXA4(2), ANXA5(1), ANXA6(6), CYP11A1(13), EDN1(8), EDNRA(8), EDNRB(4), HPGD(1), HSD11B1(11), HSD11B2(2), PLA2G4A(11), PRL(1), PTGDR(9), PTGDS(2), PTGER2(6), PTGER4(1), PTGFR(20), PTGIR(5), PTGIS(12), PTGS1(17), PTGS2(10), S100A6(1), SCGB1A1(1), TBXAS1(11) 6837460 173 90 165 73 122 17 3 15 16 0 0.00135 1.000 1.000 262 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(4), CRK(2), CXCL12(2), CXCR4(3), GNAI1(1), GNAQ(4), HRAS(3), MAP2K1(10), MAPK1(4), MAPK3(1), NFKB1(7), PIK3C2G(43), PIK3CA(8), PIK3R1(3), PLCG1(9), PRKCA(10), PTK2(8), PTK2B(10), PXN(3), RAF1(8), RELA(4) 9181105 147 89 134 74 97 9 3 24 13 1 0.464 1.000 1.000 263 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(5), ACTG2(4), ADCY3(3), ADCY9(9), AK1(1), ARF4(3), ARF5(1), ARL4D(2), ATP6V0A1(9), ATP6V0A2(4), ATP6V0A4(19), ATP6V0D2(8), ATP6V0E1(1), ATP6V1A(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), ERO1L(5), GNAS(19), PDIA4(4), PLCG1(9), PLCG2(25), PRKCA(10), SEC61A1(2), SEC61A2(7), TRIM23(2) 12409914 180 89 174 115 121 8 9 24 18 0 0.700 1.000 1.000 264 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(3), GHR(25), GRB2(2), HRAS(3), INSR(20), IRS1(5), JAK2(9), MAP2K1(10), MAPK1(4), MAPK3(1), PIK3CA(8), PIK3R1(3), PLCG1(9), PRKCA(10), PTPN6(3), RAF1(8), RPS6KA1(6), SHC1(1), SLC2A4(8), SOS1(8), SRF(2), STAT5A(2), STAT5B(4) 11091876 154 88 144 83 93 13 7 26 14 1 0.664 1.000 1.000 265 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(16), CALCR(15), CALCRL(14), CD97(6), CRHR1(6), CRHR2(2), ELTD1(23), EMR1(27), EMR2(4), GHRHR(4), GIPR(2), GLP1R(11), GLP2R(14), GPR64(5), LPHN1(6), LPHN2(34), LPHN3(20), SCTR(7), VIPR1(4), VIPR2(5) 8798714 225 88 210 145 163 15 12 16 19 0 0.345 1.000 1.000 266 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(6), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), CYP2C19(35), CYP2C9(35), DHRS1(3), DHRS2(6), DHRS3(4), DHRS7(1), DHRSX(4), ECHS1(2), EHHADH(6), ESCO1(1), ESCO2(2), HADHA(8), MYST3(15), MYST4(14), NAT6(2), PNPLA3(2), SH3GLB1(2), YOD1(1) 10382642 181 88 169 122 120 18 9 21 13 0 0.971 1.000 1.000 267 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(3), AKT2(8), AKT3(4), CISH(3), GRB2(2), IARS(8), IL13RA1(3), IL2RG(3), IL4(1), IL4R(13), INPP5D(31), JAK1(6), JAK2(9), JAK3(6), NR0B2(6), PI3(6), PIK3CA(8), PPP1R13B(6), RPS6KB1(2), SERPINA4(14), SHC1(1), SOS1(8), SOS2(11), SRC(1), STAT6(7), TYK2(7) 12308248 177 88 171 85 116 11 9 24 17 0 0.390 1.000 1.000 268 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 32 AGT(5), AGTR1(10), ATF2(5), CALM1(1), CALM2(1), EGFR(22), ELK1(2), GNAQ(4), GRB2(2), HRAS(3), JUN(1), MAP2K1(10), MAP2K2(3), MAP2K4(4), MAP3K1(2), MAPK1(4), MAPK3(1), MAPK8(1), MEF2A(5), MEF2B(2), MEF2C(2), MEF2D(4), PAK1(4), PRKCA(10), PTK2(8), PTK2B(10), RAF1(8), SHC1(1), SOS1(8), SRC(1), SYT1(19) 11028980 163 87 149 94 106 12 7 22 16 0 0.889 1.000 1.000 269 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(11), DIAPH1(6), FYN(6), GSN(6), HRAS(3), ITGA1(18), ITGB1(4), MAP2K1(10), MAPK1(4), MAPK3(1), MYL2(5), MYLK(39), PIK3CA(8), PIK3R1(3), PTK2(8), PXN(3), RAF1(8), ROCK1(5), SHC1(1), SRC(1), TLN1(12) 12476976 162 87 149 77 106 12 5 25 13 1 0.322 1.000 1.000 270 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(26), AKT1(3), GNAI1(1), ITGAV(9), ITGB3(11), MAPK1(4), MAPK3(1), PDGFA(1), PDGFRA(27), PIK3CA(8), PIK3R1(3), PLCB1(48), PRKCA(10), PTK2(8), SMPD1(3), SMPD2(1), SPHK1(1), SRC(1) 9068809 166 87 159 78 117 8 6 19 15 1 0.121 1.000 1.000 271 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(34), ACE2(7), AGT(5), AGTR1(10), AGTR2(9), ANPEP(17), CMA1(5), CPA3(18), CTSA(4), CTSG(4), ENPEP(32), LNPEP(10), MAS1(3), MME(19), NLN(4), REN(9), THOP1(7) 7039142 197 87 187 101 139 17 12 12 17 0 0.0610 1.000 1.000 272 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(5), ICAM1(2), ITGA4(36), ITGAL(24), ITGAM(21), ITGB1(4), ITGB2(13), SELE(34), SELL(8), SELP(30) 5272867 177 87 168 57 135 4 5 14 19 0 0.000338 1.000 1.000 273 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(5), AKT1(3), AKT2(8), AKT3(4), DAG1(5), GNAQ(4), ITPKB(6), ITPR1(29), ITPR2(17), ITPR3(6), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PDK1(2), PHKA2(7), PIK3CB(21), PITX2(4), PLD1(11), PLD2(5), PLD3(1) 14967109 159 87 151 100 78 17 13 32 19 0 0.805 1.000 1.000 274 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), DAG1(5), ITPKB(6), ITPR1(29), ITPR2(17), ITPR3(6), NFAT5(7), PDE6A(11), PDE6B(13), PDE6C(23), PDE6D(2), PDE6G(2), SLC6A13(25), TF(11) 11911801 175 87 164 110 124 10 6 15 20 0 0.423 1.000 1.000 275 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(3), ACP2(2), ACP5(3), ACP6(11), ACPP(8), ALPI(8), ALPL(9), ALPP(9), ALPPL2(11), CMBL(4), CYP3A4(19), CYP3A43(15), CYP3A5(10), CYP3A7(18), DHRS1(3), DHRS2(6), DHRS3(4), DHRS7(1), DHRSX(4), PON1(14), PON2(1), PON3(5) 6005264 168 86 159 54 124 11 7 11 15 0 6.23e-06 1.000 1.000 276 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(2), EXT2(6), EXTL1(2), EXTL3(10), GLCE(8), HS2ST1(1), HS3ST1(10), HS3ST2(7), HS3ST3A1(4), HS3ST3B1(2), HS3ST5(8), HS6ST1(3), HS6ST2(2), HS6ST3(12), NDST1(4), NDST2(2), NDST3(23), NDST4(45) 6796761 151 86 146 81 98 11 5 19 18 0 0.267 1.000 1.000 277 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(4), ARSB(1), FUCA1(2), GALNS(4), GBA(3), GLB1(8), GNS(2), GUSB(3), HEXA(5), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(4), HYAL1(2), HYAL2(1), IDS(9), IDUA(4), LCT(40), MAN2B1(7), MAN2B2(8), MAN2C1(3), MANBA(7), NAGLU(4), NEU1(7), NEU2(14), NEU3(3), NEU4(9), SPAM1(20) 11407574 193 86 190 98 138 15 5 19 16 0 0.169 1.000 1.000 278 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(2), AKT1(3), AKT2(8), AKT3(4), BTK(15), DAPP1(5), GRB2(2), GSK3B(2), IARS(8), IGFBP1(3), INPP5D(31), PDK1(2), PIK3CA(8), PPP1R13B(6), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(1), SOS1(8), SOS2(11), TEC(10), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3) 11579819 153 86 145 59 96 11 11 21 14 0 0.0801 1.000 1.000 279 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(9), EEF1B2(1), EEF1D(1), EEF1G(1), EEF2(2), EEF2K(5), EIF1AX(3), EIF2AK1(3), EIF2AK2(5), EIF2AK3(17), EIF2B1(9), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(1), EIF2S1(1), EIF4A1(3), EIF4A2(3), EIF4EBP1(1), EIF4G1(13), EIF4G3(17), EIF5(1), EIF5B(2), ETF1(2), GSPT2(8), KIAA0664(4), PABPC1(5), PABPC3(9), PAIP1(7), SLC35A4(4) 14601616 142 86 133 76 70 13 9 21 29 0 0.905 1.000 1.000 280 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(9), CARM1(6), CCND1(1), CREBBP(20), EP300(14), ERCC3(4), ESR1(5), GRIP1(9), GTF2A1(2), GTF2E1(2), GTF2F1(5), HDAC1(1), HDAC2(1), HDAC3(5), HDAC4(10), HDAC5(6), HDAC6(2), MEF2C(2), NCOR2(24), NR0B1(2), NRIP1(8), PELP1(10), POLR2A(11), TBP(4) 15184305 163 85 162 80 111 6 11 24 11 0 0.473 1.000 1.000 281 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(9), ACACA(21), ACACB(17), ACADM(5), ACAT2(1), ACSS1(1), ACSS2(4), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH6A1(3), ALDH7A1(9), ALDH9A1(2), ECHS1(2), EHHADH(6), HADHA(8), HIBCH(1), LDHA(5), LDHAL6A(4), LDHAL6B(7), LDHB(2), LDHC(5), MCEE(2), MLYCD(2), MUT(5), PCCA(3), PCCB(2), SUCLG1(2), SUCLG2(2) 13332782 151 85 145 82 88 14 14 25 10 0 0.597 1.000 1.000 282 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(4), CAPN1(4), CAPN2(6), CAPNS1(1), CXCR3(4), EGF(18), EGFR(22), HRAS(3), ITGA1(18), ITGB1(4), MAPK1(4), MAPK3(1), MYL2(5), MYLK(39), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PTK2(8), PXN(3), TLN1(12) 10849171 178 85 172 106 125 11 8 19 15 0 0.536 1.000 1.000 283 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(3), ATF1(4), CDC42(2), CREB3(1), CREB5(9), DUSP10(6), EEF2K(5), ELK1(2), HSPB1(2), IL1R1(11), MAP2K3(7), MAP2K4(4), MAP2K6(3), MAP3K10(8), MAP3K4(16), MAP3K5(16), MAP3K7(1), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MKNK1(5), MKNK2(2), MYEF2(4), NFKB1(7), NR2C2(2), SRF(2), TRAF6(4) 11124546 147 85 143 81 95 12 3 23 14 0 0.641 1.000 1.000 284 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(6), BAX(3), BCL2(2), BIRC2(5), BIRC3(7), CASP2(1), CASP3(2), CASP7(4), CASP8(8), CASP9(3), CYCS(1), FAS(5), FASLG(14), GZMB(3), JUN(1), MAP2K4(4), MAP3K1(2), MAP3K14(3), MAPK10(8), MCL1(3), MDM2(3), MYC(5), NFKB1(7), NFKBIA(2), PARP1(8), PRF1(11), RELA(4), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TNFSF10(7), TRAF1(6), TRAF2(2) 12176215 148 84 148 68 88 17 11 17 15 0 0.258 1.000 1.000 285 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(6), AZIN1(1), BTG1(2), CBX3(1), CLOCK(4), CRY1(7), CRY2(3), DAZAP2(1), DNAJA1(1), EIF4G2(5), ETV6(11), GFRA1(8), GSTM3(4), GSTP1(2), HERPUD1(2), HSPA8(5), IDI1(1), KLF9(2), MYF6(12), NCKAP1(5), NCOA4(4), NR1D2(9), PER1(8), PER2(11), PIGF(2), PPP1R3C(3), PPP2CB(2), PSMA4(1), PURA(3), SF3A3(4), TOB1(2), TUBB3(5), UCP3(4), UGP2(1), VAPA(1), ZFR(8) 12209248 151 84 149 67 72 14 12 32 21 0 0.652 1.000 1.000 286 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(3), CABIN1(9), CALM1(1), CALM2(1), CAMK1(4), CAMK1G(9), HDAC5(6), IGF1(11), IGF1R(10), INSR(20), MAP2K6(3), MAPK14(5), MAPK7(4), MEF2A(5), MEF2B(2), MEF2C(2), MEF2D(4), MYOD1(1), NFATC1(15), NFATC2(9), PIK3CA(8), PIK3R1(3), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYT1(19) 11648624 165 84 157 87 110 15 5 23 11 1 0.368 1.000 1.000 287 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(9), ADC(5), ALDH4A1(6), ALDH5A1(10), CAD(15), CPS1(21), EPRS(9), GAD1(13), GAD2(7), GCLC(5), GCLM(2), GFPT1(4), GFPT2(5), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(2), GMPS(4), GOT1(6), GOT2(5), GPT(3), GPT2(1), GSR(2), GSS(7), NADSYN1(4), NAGK(1), QARS(6) 13224692 163 84 157 87 91 21 11 25 15 0 0.438 1.000 1.000 288 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(19), AXIN1(10), CREBBP(20), CTNNB1(11), EP300(14), FZD1(4), GSK3B(2), HDAC1(1), LDB1(2), LEF1(3), PITX2(4), TRRAP(40), WNT1(2) 11122495 132 84 128 74 71 10 10 22 19 0 0.915 1.000 1.000 289 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(18), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH9A1(2), AOC2(7), AOC3(8), ASPA(3), CNDP1(8), DDC(12), HAL(12), HARS(6), HDC(19), HNMT(1), MAOA(3), MAOB(13), PRPS1(2), PRPS2(3) 8128303 162 83 158 106 108 15 10 14 15 0 0.657 1.000 1.000 290 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(18), ACY1(1), ADC(5), AGMAT(3), ALDH18A1(7), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), AOC2(7), AOC3(8), ARG1(1), ARG2(1), ASL(6), ASS1(7), CPS1(21), GATM(5), MAOA(3), MAOB(13), NAGS(1), ODC1(3), OTC(3), SAT2(1), SMS(5) 9753586 151 83 146 93 91 16 12 16 16 0 0.628 1.000 1.000 291 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(2), IFNA1(1), IFNB1(6), IKBKB(3), IL1A(4), IL1B(6), IL1R1(11), IL1RAP(4), IL1RN(8), IL6(2), IRAK1(4), IRAK2(14), IRAK3(7), JUN(1), MAP2K3(7), MAP2K6(3), MAP3K1(2), MAP3K14(3), MAP3K7(1), MAPK14(5), MAPK8(1), MYD88(3), NFKB1(7), NFKBIA(2), RELA(4), TGFB1(1), TGFB2(1), TGFB3(3), TNF(1), TOLLIP(1), TRAF6(4) 9854248 122 83 119 66 75 12 4 18 13 0 0.543 1.000 1.000 292 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(3), UCHL1(4), UCHL3(2), UGDH(1), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(6), UGT1A9(10), UGT2B15(25), UGT2B4(31) 5931112 147 83 134 78 101 15 10 6 14 1 0.220 1.000 1.000 293 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(16), ANAPC10(1), ANAPC2(4), ANAPC4(4), ANAPC5(6), ANAPC7(6), BTRC(4), CDC16(1), CDC20(1), CDC23(3), CDC27(9), CUL1(5), CUL2(4), CUL3(4), FBXW11(5), FBXW7(11), FZR1(6), ITCH(7), SKP2(2), SMURF1(1), SMURF2(9), TCEB1(1), TCEB2(1), UBA1(3), UBE2D1(1), UBE2D3(3), UBE2E1(1), UBE2E2(4), UBE2E3(1), VHL(4), WWP1(3), WWP2(7) 13340391 138 82 131 60 84 4 10 23 16 1 0.582 1.000 1.000 294 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(9), ACACA(21), ACADL(4), ACADM(5), ACADSB(6), ACAT2(1), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH6A1(3), ALDH9A1(2), ECHS1(2), EHHADH(6), HADHA(8), LDHA(5), LDHB(2), LDHC(5), MCEE(2), MLYCD(2), MUT(5), PCCA(3), PCCB(2), SDS(2), SUCLG1(2), SUCLG2(2) 11127967 135 82 131 68 84 12 10 22 7 0 0.528 1.000 1.000 295 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 20 ANPEP(17), CD33(17), CD5(6), CSF2(2), IFNA1(1), IFNB1(6), IFNG(2), IL10(3), IL12A(3), IL12B(3), IL13(2), IL3(3), IL4(1), IL5(4), ITGAX(18), TLR2(15), TLR4(31), TLR7(15), TLR9(14) 5960114 163 81 159 90 113 13 8 12 17 0 0.0175 1.000 1.000 296 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(6), BCL2(2), BIRC2(5), BIRC3(7), CASP10(4), CASP3(2), CASP7(4), CASP8(8), CASP9(3), CFLAR(4), CHUK(2), CYCS(1), DFFA(2), DFFB(3), GAS2(12), LMNA(8), MAP3K14(3), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), SPTAN1(7), TNFRSF10A(5), TNFRSF10B(2), TNFRSF25(5), TNFSF10(7), TNFSF12(1), TRAF2(2) 11180538 119 81 119 72 67 14 10 20 8 0 0.890 1.000 1.000 297 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(26), F2(9), F2R(6), FGA(38), FGB(10), FGG(7), PLAT(3), PLAU(3), PLG(30), SERPINB2(16), SERPINE1(5) 4467595 154 81 146 60 115 11 8 12 8 0 0.0486 1.000 1.000 298 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(12), ATR(20), BRCA1(9), CDC25A(8), CDC25B(4), CDC25C(4), CDC34(4), CDKN1A(4), CHEK1(2), CHEK2(2), EP300(14), MDM2(3), MYT1(21), PRKDC(18), RPS6KA1(6), WEE1(2), YWHAQ(3) 13795922 136 81 133 59 81 13 7 21 14 0 0.494 1.000 1.000 299 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(2), GTF2A1L(5), GTF2A2(1), GTF2B(3), GTF2E1(2), GTF2E2(5), GTF2F1(5), GTF2F2(2), GTF2H1(3), GTF2H3(1), GTF2H4(1), GTF2I(2), GTF2IRD1(8), TAF1(10), TAF13(2), TAF1L(53), TAF2(5), TAF4(8), TAF4B(2), TAF5L(3), TAF6(3), TAF6L(4), TAF7(2), TAF7L(11), TAF9(2), TAF9B(1), TBPL1(1), TBPL2(4) 12129318 151 81 147 64 102 12 6 22 9 0 0.299 1.000 1.000 300 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(24), ATP4B(1), ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(19), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), ATP7A(9), ATP7B(17), COX10(5), COX5B(1), COX6A1(1), COX6B1(1), COX6C(1), COX7B(1), COX8A(1), NDUFA10(2), NDUFA4(1), NDUFB2(3), NDUFB5(3), NDUFB6(2), NDUFS2(2), NDUFV1(2), PPA2(3), SDHA(1), SDHB(1), SHMT1(1), UQCRC1(3), UQCRFS1(2) 12844351 156 81 155 94 94 8 18 21 15 0 0.803 1.000 1.000 301 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(26), CD3D(5), CD3E(2), CD3G(1), CD4(6), CREBBP(20), CSK(1), GNAS(19), HLA-DRA(11), HLA-DRB1(3), LCK(12), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PTPRC(30), ZAP70(7) 7569321 165 80 160 97 112 14 7 17 15 0 0.690 1.000 1.000 302 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(26), AKT1(3), BAX(3), BCL2(2), CSF2RB(17), IGF1(11), IGF1R(10), IL3(3), IL3RA(7), KIT(9), KITLG(8), PIK3CA(8), PIK3R1(3), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5) 7317986 132 80 128 80 85 13 7 12 14 1 0.597 1.000 1.000 303 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(7), ABAT(9), ACADS(4), ACAT2(1), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH5A1(10), ALDH9A1(2), ECHS1(2), EHHADH(6), GAD1(13), GAD2(7), HADHA(8), HMGCL(4), L2HGDH(3), OXCT1(4), PDHA1(3), PDHA2(17), PDHB(1), SDHB(1), SDS(2) 8679698 140 80 135 66 89 16 4 18 13 0 0.121 1.000 1.000 304 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(26), CD3D(5), CD3E(2), CD3G(1), CD4(6), CREBBP(20), CSK(1), GNAS(19), HLA-DRA(11), HLA-DRB1(3), LCK(12), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PTPRC(30), ZAP70(7) 7569321 165 80 160 97 112 14 7 17 15 0 0.690 1.000 1.000 305 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 21 ACAD8(1), ACAD9(1), ADH1A(14), ADH1B(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), DHRS1(3), DHRS2(6), DHRS3(4), DHRS7(1), DHRSX(4), ESCO1(1), ESCO2(2), MYST3(15), MYST4(14), NAT6(2), PNPLA3(2), SH3GLB1(2) 8132684 142 80 129 68 101 11 6 18 6 0 0.439 1.000 1.000 306 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(3), BCL2(2), CBL(8), CFLAR(4), CRKL(2), E2F1(5), FOS(2), GRB2(2), HRAS(3), IL2RA(4), IL2RB(7), IL2RG(3), IRS1(5), JAK1(6), JAK3(6), MAPK1(4), MAPK3(1), MYC(5), NMI(1), PIK3CA(8), PIK3R1(3), PPIA(1), PTPN6(3), RAF1(8), RPS6KB1(2), SHC1(1), SOCS3(2), SOS1(8), STAT5A(2), STAT5B(4), SYK(14) 12028627 129 80 127 72 74 12 11 17 14 1 0.787 1.000 1.000 307 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(26), ARHGEF1(1), F2(9), F2R(6), F2RL3(3), GNA12(3), GNA13(1), GNAI1(1), GNAQ(4), MAP3K7(1), PIK3CA(8), PIK3R1(3), PLCB1(48), PPP1R12B(8), PRKCA(10), PTK2B(10), ROCK1(5) 8640233 147 80 140 77 103 10 5 17 11 1 0.401 1.000 1.000 308 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 27 BCAR1(4), CALM1(1), CALM2(1), CRKL(2), GNAQ(4), GRB2(2), HRAS(3), JUN(1), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP3K1(2), MAPK1(4), MAPK14(5), MAPK3(1), MAPK8(1), PAK1(4), PLCG1(9), PRKCA(10), PTK2B(10), RAF1(8), SHC1(1), SOS1(8), SRC(1), SYT1(19) 9368287 125 80 114 72 77 11 5 20 12 0 0.842 1.000 1.000 309 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(19), CAMP(1), CASP3(2), CERK(1), CREB3(1), CREB5(9), DAG1(5), EPHB2(29), FOS(2), GNAQ(4), ITPKB(6), JUN(1), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK8(1), MAPK8IP1(4), MAPK8IP2(7), MAPK8IP3(8), MAPK9(5) 9504529 125 80 123 68 76 8 5 17 19 0 0.706 1.000 1.000 310 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(8), F2(9), F2R(6), F5(30), F7(7), FGA(38), FGB(10), FGG(7), PROC(8), PROS1(13), SERPINC1(7), TFPI(8) 5493980 151 79 140 59 102 20 9 12 8 0 0.0545 1.000 1.000 311 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK8(1), MAPK8IP1(4), MAPK8IP2(7), MAPK8IP3(8), MAPK9(5), MAPKAPK5(1), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PIK3CA(8), PIK3CD(7), PIK3R1(3), SYT1(19), TRAF2(2), TRAF3(5), TRAF5(7), TRAF6(4) 11171128 134 79 128 81 84 9 6 24 10 1 0.692 1.000 1.000 312 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(16), FOS(2), HRAS(3), JUN(1), MAP2K1(10), MAPK1(4), MAPK3(1), MYC(5), NFKB1(7), NFKBIA(2), PLCB1(48), PRKCA(10), RAF1(8), RELA(4), TNF(1) 5212313 122 78 111 49 84 8 6 14 10 0 0.0225 1.000 1.000 313 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), EGF(18), EGFR(22), ELK1(2), FOS(2), GRB2(2), HRAS(3), JAK1(6), JUN(1), MAP2K1(10), MAP2K4(4), MAP3K1(2), MAPK3(1), MAPK8(1), PIK3CA(8), PIK3R1(3), PLCG1(9), PRKCA(10), RAF1(8), RASA1(4), SHC1(1), SOS1(8), SRF(2), STAT1(4), STAT3(10), STAT5A(2) 12513816 144 78 137 78 84 14 7 25 13 1 0.893 1.000 1.000 314 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(12), ABCC2(9), ABCG2(6), BCHE(6), CES1(16), CES2(4), CYP3A4(19), CYP3A5(10), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(6), UGT1A9(10) 7667525 161 78 151 76 109 14 11 10 17 0 0.0157 1.000 1.000 315 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 38 ATF2(5), CDC42(2), DAXX(9), DDIT3(2), ELK1(2), GRB2(2), HMGN1(2), HRAS(3), HSPB1(2), HSPB2(1), MAP2K4(4), MAP2K6(3), MAP3K1(2), MAP3K5(16), MAP3K7(1), MAP3K9(22), MAPK14(5), MAPKAPK2(5), MAPKAPK5(1), MEF2A(5), MEF2B(2), MEF2C(2), MEF2D(4), MKNK1(5), MYC(5), PLA2G4A(11), RIPK1(1), RPS6KA5(4), SHC1(1), STAT1(4), TGFB1(1), TGFB2(1), TGFB3(3), TRAF2(2) 12002968 140 78 136 58 88 12 3 20 17 0 0.263 1.000 1.000 316 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(9), ALDH4A1(6), ALDH5A1(10), CAD(15), CPS1(21), EPRS(9), GAD1(13), GAD2(7), GCLC(5), GCLM(2), GFPT1(4), GLS(2), GLS2(3), GLUD1(2), GLUL(2), GMPS(4), GOT1(6), GOT2(5), GPT(3), GPT2(1), GSS(7), NADSYN1(4), QARS(6) 11120950 146 77 140 70 84 16 10 23 13 0 0.256 1.000 1.000 317 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(2), ALDOB(12), ALDOC(3), FBP1(2), FBP2(2), GOT1(6), GOT2(5), GPT(3), GPT2(1), MDH1(1), MDH2(4), ME1(19), ME3(9), PGK1(4), PGK2(27), PKLR(11), PKM2(5), TKT(6), TKTL1(1), TKTL2(24) 6780089 147 77 136 78 107 14 5 12 9 0 0.0529 1.000 1.000 318 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(14), ABP1(18), AOC2(7), AOC3(8), CES1(16), CES7(14), DDHD1(6), ESCO1(1), ESCO2(2), LIPA(4), MYST3(15), MYST4(14), NAT6(2), PLA1A(9), PNPLA3(2), PPME1(1), PRDX6(4), SH3GLB1(2) 8492972 139 77 135 80 101 8 8 11 11 0 0.816 1.000 1.000 319 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(2), POLA2(8), POLD1(6), POLD2(2), POLD3(4), POLE(15), POLE2(3), POLG(8), POLG2(5), POLH(3), POLI(1), POLK(6), POLL(7), POLM(2), POLQ(23), PRIM1(3), PRIM2(14), REV1(3), REV3L(11) 13549282 126 77 124 54 70 7 7 27 15 0 0.497 1.000 1.000 320 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(9), CCR2(16), CCR3(10), CCR4(7), CCR5(7), CCR7(3), CD28(1), CD4(6), CSF2(2), CXCR3(4), CXCR4(3), IFNG(2), IFNGR1(4), IFNGR2(4), IL12A(3), IL12B(3), IL12RB1(15), IL12RB2(3), IL18R1(17), IL2(4), IL4(1), IL4R(13), IL5(4), TGFB1(1), TGFB2(1), TGFB3(3) 6677468 146 77 139 78 104 12 1 15 14 0 0.0604 1.000 1.000 321 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(3), JAK1(6), JUN(1), MAP2K1(10), MAP2K4(4), MAP3K1(2), MAPK3(1), MAPK8(1), PDGFA(1), PDGFRA(27), PIK3CA(8), PIK3R1(3), PLCG1(9), PRKCA(10), RAF1(8), RASA1(4), SHC1(1), SOS1(8), SRF(2), STAT1(4), STAT3(10), STAT5A(2) 11651546 132 77 125 60 73 14 6 24 14 1 0.497 1.000 1.000 322 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(2), CDT1(1), DIAPH2(7), MCM10(6), MCM2(10), MCM3(10), MCM4(5), MCM5(4), MCM6(4), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), POLA2(8), POLD1(6), POLD2(2), POLD3(4), POLE(15), POLE2(3), PRIM1(3), RFC1(5), RFC2(2), RFC3(1), RPA1(3), RPA2(2), RPA3(1), RPA4(2), UBB(1), UBC(6) 16939265 129 76 128 77 77 9 5 22 16 0 0.879 1.000 1.000 323 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(3), CASP10(4), CASP3(2), CASP7(4), CASP8(8), CFLAR(4), DAXX(9), DFFA(2), DFFB(3), FAF1(7), JUN(1), LMNA(8), LMNB1(2), LMNB2(4), MAP2K4(4), MAP3K1(2), MAP3K7(1), MAPK8(1), PAK1(4), PAK2(8), PRKDC(18), PTPN13(12), RB1(8), RIPK2(2), SPTAN1(7) 13724799 128 76 128 61 58 12 10 32 14 2 0.766 1.000 1.000 324 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(8), ALDOA(2), ALDOB(12), ALDOC(3), FBP1(2), FBP2(2), FPGT(2), FUK(3), GMDS(5), GMPPA(1), GMPPB(3), HK1(3), HK2(12), HK3(13), HSD3B7(3), KHK(1), LHPP(1), MPI(1), MTMR1(4), MTMR2(2), MTMR6(2), PFKFB1(4), PFKFB2(5), PFKFB3(2), PFKFB4(5), PFKL(4), PFKM(1), PGM2(6), PMM1(2), PMM2(1), RDH11(2), RDH12(2), RDH13(3), SORD(2), TSTA3(2) 12342776 128 76 124 85 86 15 10 11 6 0 0.519 1.000 1.000 325 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(5), BAIAP2(5), CASP1(4), CASP3(2), CASP7(4), CASP8(8), GAPDH(1), INSR(20), ITCH(7), MAGI1(26), MAGI2(22), RERE(21), WWP1(3), WWP2(7) 8064230 135 76 133 62 91 9 3 20 11 1 0.437 1.000 1.000 326 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(5), AASDH(5), AASDHPPT(3), AASS(3), ACAT2(1), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2), BBOX1(4), DOT1L(8), ECHS1(2), EHHADH(6), EHMT1(7), EHMT2(9), GCDH(5), HADHA(8), PLOD1(5), PLOD2(6), PLOD3(4), SDS(2), SHMT1(1), SHMT2(2), TMLHE(1) 12307643 125 76 121 73 78 14 4 20 9 0 0.623 1.000 1.000 327 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 21 AKT1(3), EIF4A1(3), EIF4A2(3), EIF4EBP1(1), EIF4G1(13), EIF4G2(5), EIF4G3(17), GHR(25), IRS1(5), MAPK1(4), MAPK14(5), MAPK3(1), MKNK1(5), PABPC1(5), PDK2(4), PDPK1(4), PIK3CA(8), PIK3R1(3), PRKCA(10), RPS6KB1(2) 9207918 126 75 120 51 75 15 7 12 16 1 0.188 1.000 1.000 328 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 14 ADH1A(14), ADH1B(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2) 4166776 116 75 102 46 83 10 9 9 5 0 0.0120 1.000 1.000 329 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(11), ARHGEF1(1), GNA12(3), GNA13(1), GNAQ(4), MYL2(5), MYLK(39), PLCB1(48), PPP1R12B(8), PRKCA(10), ROCK1(5) 6957125 135 75 124 61 105 4 5 13 8 0 0.160 1.000 1.000 330 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), ERCC3(4), GTF2A2(1), GTF2B(3), GTF2E1(2), GTF2E2(5), GTF2F2(2), GTF2H1(3), GTF2H4(1), MNAT1(2), POLR1A(11), POLR1B(8), POLR2A(11), POLR2B(11), POLR2C(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR3B(15), POLR3D(1), POLR3E(4), POLR3H(1), POLR3K(1), TAF13(2), TAF6(3), TAF7(2), TAF9(2), TBP(4) 11766125 109 75 107 43 65 9 8 19 8 0 0.141 1.000 1.000 331 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(10), CSF1R(12), DDX20(8), E2F1(5), E2F4(1), ETS1(4), ETS2(8), ETV3(4), FOS(2), HDAC2(1), HDAC5(6), HRAS(3), JUN(1), NCOR2(24), RBL1(10), RBL2(4), SIN3A(9), SIN3B(7) 8690075 119 74 119 61 78 7 2 21 11 0 0.361 1.000 1.000 332 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(2), CREBBP(20), EP300(14), FYN(6), IL2RG(3), IL7(5), IL7R(27), JAK1(6), JAK3(6), LCK(12), NMI(1), PIK3CA(8), PIK3R1(3), PTK2B(10), STAT5A(2), STAT5B(4) 9325820 129 74 126 67 80 13 5 19 11 1 0.652 1.000 1.000 333 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(5), ICAM1(2), ITGA4(36), ITGAL(24), ITGB1(4), ITGB2(13), SELE(34), SELL(8) 4009140 126 74 122 39 94 4 4 9 15 0 0.00256 1.000 1.000 334 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 19 B2M(5), HLA-A(3), IL18(2), ITGB1(4), KLRC1(4), KLRC2(1), KLRC3(11), KLRC4(5), KLRD1(5), LAT(1), MAP2K1(10), MAPK3(1), PAK1(4), PIK3CA(8), PIK3R1(3), PTK2B(10), PTPN6(3), SYK(14), VAV1(15) 6061467 109 74 100 65 77 4 2 12 13 1 0.829 1.000 1.000 335 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(10), AGT(5), AGTR2(9), EDN1(8), EDNRA(8), EDNRB(4), EGF(18), EGFR(22), FOS(2), HRAS(3), JUN(1), MYC(5), NFKB1(7), PLCG1(9), PRKCA(10), RELA(4) 6869611 125 73 122 66 88 10 5 15 7 0 0.356 1.000 1.000 336 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(8), CSF1R(12), EGF(18), EGFR(22), GRB2(2), MET(19), PDGFRA(27), PRKCA(10), SH3GLB1(2), SH3GLB2(1), SH3KBP1(6), SRC(1) 6521461 128 73 127 79 86 10 6 13 13 0 0.874 1.000 1.000 337 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(12), ATM(12), ATR(20), CCNA1(13), CCND1(1), CCNE1(4), CDC25A(8), CDK4(5), CDK6(2), CDKN1A(4), CDKN1B(1), E2F1(5), GSK3B(2), HDAC1(1), RB1(8), SKP2(2), TFDP1(2), TGFB1(1), TGFB2(1), TGFB3(3) 9612115 107 73 105 42 60 7 8 16 14 2 0.168 1.000 1.000 338 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(1), ARSD(3), ARSE(5), GAL3ST1(8), GALC(3), GBA(3), GLA(1), GLB1(8), LCT(40), NEU1(7), NEU2(14), NEU3(3), NEU4(9), PPAP2B(6), PPAP2C(8), SMPD1(3), SMPD2(1), SPTLC1(1), SPTLC2(6), UGCG(1) 8008281 131 73 127 80 93 13 2 15 8 0 0.690 1.000 1.000 339 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 26 ACLY(9), ACO1(5), ACO2(4), CLYBL(5), CS(2), DLD(2), FH(3), IDH2(2), IDH3A(3), IDH3B(1), IDH3G(2), MDH1(1), MDH2(4), OGDH(11), OGDHL(36), PC(12), PCK1(23), PCK2(4), SDHA(1), SDHB(1), SDHC(2), SDHD(1), SUCLG1(2), SUCLG2(2) 9755178 138 73 132 71 96 4 7 17 14 0 0.204 1.000 1.000 340 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM2(1), CHUK(2), EGR2(4), EGR3(2), GNAQ(4), MAP3K1(2), MYC(5), NFATC1(15), NFATC2(9), NFKB1(7), NFKBIA(2), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RELA(4), SYT1(19), VIP(4), VIPR2(5) 9322411 128 73 124 81 87 10 7 15 9 0 0.903 1.000 1.000 341 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(6), CHAT(14), COMT(3), DBH(13), DDC(12), GAD1(13), GAD2(7), HDC(19), MAOA(3), PAH(8), PNMT(4), SLC18A3(2), TH(9), TPH1(5) 4722413 119 72 114 73 95 9 4 3 8 0 0.233 1.000 1.000 342 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(35), ABCB11(45), ABCB4(17), ABCC1(12), ABCC3(25), GSTP1(2) 4755147 136 72 128 67 89 15 5 11 16 0 0.00784 1.000 1.000 343 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(2), CREBBP(20), EP300(14), IKBKB(3), IL1B(6), IL8(1), MAP2K3(7), MAP2K6(3), MAP3K14(3), MAP3K7(1), MAPK11(1), MAPK14(5), MYD88(3), NFKB1(7), NFKBIA(2), NR3C1(7), RELA(4), TGFBR2(7), TLR2(15), TNF(1) 9940107 112 72 111 64 66 15 5 19 7 0 0.885 1.000 1.000 344 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(4), GALNT10(6), GALNT2(6), GALNT3(3), GALNT4(4), GALNT6(15), GALNT7(5), GALNT8(23), GALNT9(5), GCNT1(6), ST3GAL1(6), ST3GAL2(1), ST3GAL4(1), WBSCR17(37) 4849146 122 72 114 57 92 8 4 9 9 0 0.121 1.000 1.000 345 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 20 AARS(5), ABAT(9), ADSL(6), ADSS(2), AGXT(10), ASL(6), ASNS(8), ASPA(3), CAD(15), CRAT(5), DARS(4), DDO(7), GAD1(13), GAD2(7), GOT1(6), GOT2(5), GPT(3), GPT2(1), NARS(2), PC(12) 8418935 129 71 126 73 88 15 8 12 6 0 0.277 1.000 1.000 346 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 25 ADCY1(26), AKT1(3), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), GNAS(19), GRB2(2), HRAS(3), MAPK1(4), MAPK14(5), MAPK3(1), PIK3CA(8), PIK3R1(3), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), RPS6KA1(6), RPS6KA5(4), SOS1(8) 9522687 142 71 137 96 96 11 6 13 15 1 0.969 1.000 1.000 347 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(4), DAB1(40), FYN(6), LRP8(3), RELN(70), VLDLR(5) 4675358 128 71 123 64 92 7 3 12 14 0 0.659 1.000 1.000 348 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(3), AKT2(8), AKT3(4), BCL2(2), GRB2(2), GSK3B(2), IL4R(13), IRS1(5), IRS2(2), JAK1(6), JAK3(6), MAP4K1(9), MAPK1(4), MAPK3(1), PDK1(2), PIK3CA(8), PIK3CD(7), PIK3R1(3), PPP1R13B(6), RAF1(8), SHC1(1), SOS1(8), SOS2(11), STAT6(7) 12211749 128 71 127 55 72 16 5 21 13 1 0.196 1.000 1.000 349 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(3), BCL2(2), EGFR(22), IGF1R(10), MYC(5), POLR2A(11), PPP2CA(1), PRKCA(10), RB1(8), TEP1(30), TERF1(2), TERT(6), TNKS(7), XRCC5(2) 9128282 119 71 117 74 75 10 8 14 10 2 0.798 1.000 1.000 350 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(19), AXIN1(10), BTRC(4), CCND1(1), CREBBP(20), CSNK1A1(2), CSNK1D(1), CSNK2A1(1), CTNNB1(11), FZD1(4), GSK3B(2), HDAC1(1), MAP3K7(1), MYC(5), NLK(5), PPARD(3), PPP2CA(1), TLE1(4), WIF1(7), WNT1(2) 9761165 104 71 103 55 54 7 8 16 19 0 0.865 1.000 1.000 351 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(4), CSNK1D(1), DRD1(8), DRD2(15), GRM1(16), PLCB1(48), PPP1CA(1), PPP1R1B(2), PPP2CA(1), PPP3CA(5), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5) 5328567 123 70 117 81 95 2 6 11 9 0 0.696 1.000 1.000 352 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(7), GBA3(14), LPO(18), MPO(11), PRDX1(2), PRDX2(2), PRDX6(4), TPO(40), TYR(8) 3233745 106 70 101 54 82 9 1 5 9 0 0.102 1.000 1.000 353 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(12), ATR(20), BRCA1(9), BRCA2(19), CHEK1(2), CHEK2(2), FANCA(7), FANCC(3), FANCD2(12), FANCE(2), FANCF(1), FANCG(4), HUS1(1), MRE11A(5), RAD1(2), RAD17(5), RAD50(5), RAD9A(5) 14495708 116 69 114 57 76 4 5 17 14 0 0.841 1.000 1.000 354 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GALNS(4), GLB1(8), GNS(2), GUSB(3), HEXA(5), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(4), HYAL1(2), HYAL2(1), IDS(9), IDUA(4), LCT(40), NAGLU(4), SPAM1(20) 6796684 126 69 123 71 93 7 2 12 12 0 0.499 1.000 1.000 355 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPAT6(2), AGPS(3), CHPT1(1), ENPP2(1), ENPP6(11), PAFAH1B1(4), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(2), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PLD1(11), PLD2(5), PPAP2B(6), PPAP2C(8) 7807121 132 69 128 72 85 11 4 17 15 0 0.489 1.000 1.000 356 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 ATF1(4), CREB3(1), CREB5(9), DUSP4(1), DUSP6(1), DUSP9(3), EEF2K(5), GRB2(2), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), MKNK1(5), MKNK2(2), MOS(5), NFKB1(7), RAP1A(2), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), SHC1(1), SOS1(8), SOS2(11), TRAF3(5) 9331027 105 69 98 62 71 8 4 14 8 0 0.858 1.000 1.000 357 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(34), AGT(5), AGTR1(10), AGTR2(9), BDKRB2(9), KNG1(11), NOS3(16), REN(9) 3307680 103 68 97 60 68 7 6 12 10 0 0.176 1.000 1.000 358 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(9), AKR1D1(17), CYP11A1(13), CYP11B1(13), CYP11B2(13), CYP17A1(7), CYP21A2(15), HSD11B1(11), HSD11B2(2), HSD3B1(10), HSD3B2(10) 3273508 120 68 109 60 83 10 5 12 10 0 0.00916 1.000 1.000 359 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(9), AKR1D1(17), CYP11A1(13), CYP11B1(13), CYP11B2(13), CYP17A1(7), CYP21A2(15), HSD11B1(11), HSD11B2(2), HSD3B1(10), HSD3B2(10) 3273508 120 68 109 60 83 10 5 12 10 0 0.00916 1.000 1.000 360 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(3), CHIA(9), CHIT1(11), CMAS(1), CTBS(6), CYB5R1(1), GFPT1(4), GFPT2(5), GNE(3), HEXA(5), HEXB(4), HK1(3), HK2(12), HK3(13), LHPP(1), MTMR1(4), MTMR2(2), MTMR6(2), NAGK(1), NANS(1), PGM3(1), RENBP(3), UAP1(2) 9585564 97 68 95 57 61 9 5 13 9 0 0.685 1.000 1.000 361 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(20), PGAP1(5), PIGA(2), PIGB(4), PIGC(3), PIGF(2), PIGG(10), PIGH(1), PIGK(6), PIGL(2), PIGM(2), PIGN(3), PIGO(12), PIGQ(8), PIGS(1), PIGT(1), PIGU(6), PIGV(7), PIGW(2), PIGX(2), PIGZ(3) 8006895 103 68 101 43 59 8 8 20 8 0 0.0744 1.000 1.000 362 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(4), ADCY1(26), CAP1(1), CDC25C(4), GNAI1(1), GNAS(19), HRAS(3), MAPK1(4), MAPK3(1), MYT1(21), PIN1(1), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RPS6KA1(6), SRC(1) 6849519 114 68 110 86 81 8 4 8 13 0 0.939 1.000 1.000 363 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(1), FOS(2), GRB2(2), HRAS(3), JAK2(9), JUN(1), MAP2K1(10), MAPK3(1), MPL(7), PIK3CA(8), PIK3R1(3), PLCG1(9), PRKCA(10), RAF1(8), RASA1(4), SHC1(1), SOS1(8), STAT1(4), STAT3(10), STAT5A(2), STAT5B(4), THPO(7) 9990156 114 67 107 52 63 11 7 22 10 1 0.591 1.000 1.000 364 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(26), ADRB2(2), CFTR(44), GNAS(19), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), SLC9A3R1(3) 4325212 116 66 109 80 80 8 6 10 12 0 0.889 1.000 1.000 365 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(18), EGFR(22), MAP2K1(10), MAP3K1(2), MAPK14(5), NCOR2(24), RARA(3), RXRA(4), THRA(2), THRB(14) 5735374 104 66 99 55 75 7 3 13 6 0 0.513 1.000 1.000 366 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(4), EPHA4(17), EPHB1(25), FYN(6), ITGA1(18), ITGB1(4), L1CAM(8), LYN(6), RAP1B(1), SELP(30) 5279238 119 66 109 65 87 4 2 16 10 0 0.539 1.000 1.000 367 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(5), CARM1(6), CBS(6), CTH(1), GGT1(6), HEMK1(4), LCMT1(4), MARS(6), MARS2(4), MAT1A(5), MAT2B(2), METTL2B(7), METTL6(2), PAPSS1(3), PAPSS2(5), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), SCLY(3), SEPHS1(4), SEPHS2(2), WBSCR22(1) 8396360 100 66 99 45 61 11 5 15 8 0 0.107 1.000 1.000 368 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(26), ADRB2(2), GNAS(19), PLCE1(48), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5) 4878055 117 66 111 71 80 9 7 11 10 0 0.724 1.000 1.000 369 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(4), DYRK1B(2), GLI2(36), GLI3(15), GSK3B(2), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), SHH(4), SMO(10), SUFU(2) 5543702 97 66 94 57 64 10 7 8 8 0 0.584 1.000 1.000 370 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(3), BAG4(3), CASP2(1), CASP3(2), CASP8(8), CRADD(1), DFFA(2), DFFB(3), JUN(1), LMNA(8), LMNB1(2), LMNB2(4), MADD(14), MAP2K4(4), MAP3K1(2), MAP3K7(1), MAPK8(1), PAK1(4), PAK2(8), PRKDC(18), RB1(8), RIPK1(1), SPTAN1(7), TNF(1), TNFRSF1A(3), TRAF2(2) 13034184 112 66 111 51 51 11 9 25 14 2 0.442 1.000 1.000 371 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM1(1), CALM2(1), CDKN1A(4), GNAQ(4), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(10), SP1(5), SP3(1), SYT1(19) 6942662 111 65 106 46 74 10 6 11 10 0 0.162 1.000 1.000 372 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(8), GABRA1(16), GABRA2(15), GABRA3(19), GABRA4(12), GABRA5(2), GABRA6(22), GPHN(7), NSF(1), SRC(1), UBQLN1(5) 3922143 108 65 96 58 81 4 5 10 7 1 0.397 1.000 1.000 373 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(2), AKT1(3), ANXA1(4), CALM1(1), CALM2(1), GNAS(19), NFKB1(7), NOS3(16), NPPA(3), NR3C1(7), PIK3CA(8), PIK3R1(3), RELA(4), SYT1(19) 5939665 97 65 90 55 71 6 2 14 3 1 0.803 1.000 1.000 374 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(3), BCL2(2), BCR(10), CRKL(2), FOS(2), GRB2(2), HRAS(3), JAK2(9), JUN(1), MAP2K1(10), MAP2K4(4), MAP3K1(2), MAPK3(1), MAPK8(1), MYC(5), PIK3CA(8), PIK3R1(3), RAF1(8), SOS1(8), STAT1(4), STAT5A(2), STAT5B(4) 9346738 94 65 88 45 50 8 6 18 11 1 0.665 1.000 1.000 375 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(2), ALDOB(12), ALDOC(3), DERA(2), FBP1(2), FBP2(2), G6PD(3), GPI(3), H6PD(5), PFKL(4), PFKM(1), PGD(7), PGLS(1), PGM1(4), PGM3(1), PRPS1(2), PRPS1L1(13), PRPS2(3), RBKS(4), TALDO1(3), TKT(6), TKTL1(1), TKTL2(24) 8105277 108 65 102 73 72 11 5 7 13 0 0.552 1.000 1.000 376 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(7), CD3D(5), CD3E(2), CD3G(1), CXCR3(4), ETV5(7), IFNG(2), IL12A(3), IL12B(3), IL12RB1(15), IL12RB2(3), IL18(2), IL18R1(17), JAK2(9), JUN(1), MAP2K6(3), MAPK14(5), MAPK8(1), STAT4(22), TYK2(7) 6206349 119 65 116 59 81 8 4 15 11 0 0.446 1.000 1.000 377 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(3), IL2(4), IL2RA(4), IL2RB(7), IL2RG(3), JAK1(6), JAK3(6), JUN(1), LCK(12), MAP2K1(10), MAPK3(1), MAPK8(1), RAF1(8), SHC1(1), SOS1(8), STAT5A(2), STAT5B(4), SYK(14) 7690955 102 65 96 49 63 9 5 16 9 0 0.337 1.000 1.000 378 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CALM2(1), CAMK1(4), CAMK1G(9), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CAMK4(10), ESRRA(2), HDAC5(6), MEF2A(5), MEF2B(2), MEF2C(2), MEF2D(4), PPARA(6), PPP3CA(5), PPP3CB(4), PPP3CC(2), SLC2A4(8), SYT1(19) 6706586 108 65 101 64 80 6 3 11 8 0 0.529 1.000 1.000 379 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(3), PIK3CA(8), PIK3R1(3), PLCB1(48), PLCG1(9), PRKCA(10), VAV1(15) 4303263 96 65 90 49 76 3 2 8 6 1 0.386 1.000 1.000 380 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(4), FUCA1(2), GLB1(8), HEXA(5), HEXB(4), LCT(40), MAN2B1(7), MAN2B2(8), MAN2C1(3), MANBA(7), NEU1(7), NEU2(14), NEU3(3), NEU4(9) 6782316 121 64 119 59 90 11 3 12 5 0 0.145 1.000 1.000 381 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(7), GBA(3), GBA3(14), LPO(18), MPO(11), PRDX6(4), TPO(40) 2807448 97 64 92 52 76 8 1 5 7 0 0.102 1.000 1.000 382 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(4), CS(2), DLAT(2), DLD(2), FH(3), IDH2(2), IDH3A(3), IDH3B(1), IDH3G(2), MDH1(1), MDH2(4), OGDH(11), PC(12), PDHA1(3), PDHA2(17), PDHB(1), PDHX(2), PDK1(2), PDK2(4), PDK3(4), PDK4(8), PDP2(5), SDHA(1), SDHB(1), SDHC(2), SDHD(1), SUCLG1(2), SUCLG2(2) 9528058 104 64 100 47 70 5 6 11 12 0 0.178 1.000 1.000 383 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(2), IKBKB(3), IL1A(4), IL1R1(11), IRAK1(4), MAP3K1(2), MAP3K14(3), MAP3K7(1), MYD88(3), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), TLR4(31), TNF(1), TNFAIP3(2), TNFRSF1A(3), TNFRSF1B(3), TRAF6(4) 8015050 91 64 88 58 62 6 5 10 8 0 0.862 1.000 1.000 384 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(4), GTF2A1(2), GTF2B(3), GTF2E1(2), GTF2F1(5), HDAC3(5), NCOA1(9), NCOA2(13), NCOA3(14), NCOR2(24), POLR2A(11), RARA(3), RXRA(4), TBP(4) 8309508 103 64 101 43 78 3 5 10 7 0 0.119 1.000 1.000 385 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 15 ACTA1(4), ACTN1(5), ACTN2(21), ACTN3(7), CAPN1(4), CAPNS1(1), ITGA1(18), ITGB1(4), ITGB3(11), PTK2(8), PXN(3), SPTAN1(7), SRC(1), TLN1(12) 9277143 106 64 104 60 68 9 5 12 11 1 0.230 1.000 1.000 386 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(2), ALDOB(12), ALDOC(3), FBP1(2), FBP2(2), FPGT(2), GCK(17), GMDS(5), GMPPA(1), GMPPB(3), HK1(3), HK2(12), HK3(13), KHK(1), MPI(1), PFKFB1(4), PFKFB3(2), PFKFB4(5), PFKM(1), PMM1(2), PMM2(1), SORD(2) 7964637 98 63 93 68 71 13 6 4 4 0 0.433 1.000 1.000 387 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(11), BCAT2(1), IARS(8), IARS2(13), ILVBL(4), LARS(10), LARS2(4), PDHA1(3), PDHA2(17), PDHB(1), VARS(18), VARS2(6) 6323882 96 63 86 41 61 11 3 12 9 0 0.197 1.000 1.000 388 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 20 AKT1(3), EIF4A1(3), EIF4A2(3), EIF4B(4), EIF4EBP1(1), EIF4G1(13), EIF4G2(5), EIF4G3(17), FKBP1A(2), MKNK1(5), PDK2(4), PDPK1(4), PIK3CA(8), PIK3R1(3), PPP2CA(1), RPS6(1), RPS6KB1(2), TSC1(5), TSC2(11) 9001463 95 63 92 40 50 11 8 12 12 2 0.316 1.000 1.000 389 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(26), GNAS(19), PPP2CA(1), PRKAA1(1), PRKAA2(24), PRKAB1(2), PRKAB2(2), PRKACB(4), PRKACG(8), PRKAG1(2), PRKAG2(7), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5) 5103428 106 62 101 63 75 8 7 4 12 0 0.729 1.000 1.000 390 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(1), ERBB4(47), NRG2(7), NRG3(20), PRKCA(10), PSEN1(1) 2982990 86 62 78 31 67 4 2 5 8 0 0.0376 1.000 1.000 391 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(10), CYP2A13(11), CYP2A6(11), CYP2A7(8), NAT1(2), NAT2(9), XDH(50) 2690942 101 62 95 60 80 4 8 4 5 0 0.0660 1.000 1.000 392 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 ANPEP(17), G6PD(3), GCLC(5), GCLM(2), GGT1(6), GPX1(3), GPX3(3), GPX5(12), GPX6(15), GSR(2), GSS(7), GSTA1(5), GSTA2(2), GSTA3(1), GSTA5(3), GSTK1(2), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTP1(2), GSTT1(1), IDH2(2), MGST1(2), MGST2(2), MGST3(1), OPLAH(8), TXNDC12(1) 7017990 123 62 119 71 84 8 6 17 8 0 0.208 1.000 1.000 393 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(21), BST1(1), CD38(4), ENPP1(11), ENPP3(14), NADK(4), NADSYN1(4), NMNAT2(3), NMNAT3(8), NNMT(9), NNT(3), NT5C1A(3), NT5C1B(22), NT5C2(3), NT5C3(2), NT5E(4), NT5M(2), NUDT12(1), QPRT(6) 7215895 125 62 121 66 81 10 6 13 15 0 0.505 1.000 1.000 394 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASNS(8), ASRGL1(3), CA1(8), CA12(3), CA13(5), CA2(9), CA3(5), CA4(3), CA5A(2), CA5B(1), CA6(4), CA7(1), CA8(4), CA9(8), CPS1(21), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(2), HAL(12) 7049279 112 62 110 49 77 8 4 13 10 0 0.125 1.000 1.000 395 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(3), CAT(5), EPX(7), LPO(18), MPO(11), PRDX1(2), PRDX2(2), PRDX6(4), SHMT1(1), SHMT2(2), TPO(40) 3961561 95 62 92 53 74 8 1 7 5 0 0.171 1.000 1.000 396 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(34), CD44(5), CSF1(10), FCGR3A(8), IL1B(6), IL6R(4), SELL(8), SPN(5), TGFB1(1), TGFB2(1), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TNFRSF8(17), TNFSF8(3) 4327349 109 62 103 46 81 5 6 5 12 0 0.0227 1.000 1.000 397 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(3), CNR1(9), CNR2(4), DNMT1(18), MTNR1A(8), MTNR1B(7), PTAFR(2), PTGDR(9), PTGER2(6), PTGER4(1), PTGFR(20), PTGIR(5), TBXA2R(4) 3730498 96 62 91 70 64 12 5 7 8 0 0.330 1.000 1.000 398 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(5), CARS(9), DARS(4), EPRS(9), FARS2(4), GARS(6), HARS(6), IARS(8), KARS(4), LARS(10), LARS2(4), MARS(6), MARS2(4), NARS(2), QARS(6), RARS(7), SARS(10), TARS(2), WARS(4), WARS2(4), YARS(1) 10796818 115 61 109 46 71 12 6 16 10 0 0.106 1.000 1.000 399 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(5), ACTN2(21), ACTN3(7), BCAR1(4), CSK(1), CTNNA1(2), CTNNA2(23), CTNNB1(11), PTK2(8), PXN(3), SRC(1), VCL(7) 6309423 93 61 90 51 58 7 4 13 10 1 0.296 1.000 1.000 400 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(3), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K6(3), MAP3K1(2), MAPK1(4), MAPK14(5), MAPK3(1), NFKB1(7), PIK3CA(8), PIK3R1(3), RB1(8), RELA(4), SP1(5) 6463992 73 61 66 39 36 7 3 13 11 3 0.854 1.000 1.000 401 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(3), IGF1(11), IGF1R(10), IRS1(5), JUN(1), MAP2K1(10), MAPK3(1), MAPK8(1), PIK3CA(8), PIK3R1(3), PTPN11(9), RAF1(8), RASA1(4), SHC1(1), SOS1(8), SRF(2) 8280583 92 61 83 42 46 16 2 19 8 1 0.622 1.000 1.000 402 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(3), INSR(20), IRS1(5), JUN(1), MAP2K1(10), MAPK3(1), MAPK8(1), PIK3CA(8), PIK3R1(3), PTPN11(9), RAF1(8), RASA1(4), SHC1(1), SLC2A4(8), SOS1(8), SRF(2) 8565014 99 61 91 46 46 14 3 25 10 1 0.695 1.000 1.000 403 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(9), CALM1(1), CALM2(1), CAPN2(6), CAPNS1(1), EP300(14), HDAC1(1), HDAC2(1), MEF2D(4), NFATC1(15), NFATC2(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(10), SYT1(19) 8210132 102 61 97 45 70 7 7 10 8 0 0.223 1.000 1.000 404 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(5), ICAM1(2), ITGAL(24), ITGAM(21), ITGB2(13), SELE(34), SELL(8) 3432646 107 61 107 40 78 4 3 7 15 0 0.00503 1.000 1.000 405 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(19), CDH1(5), CREBBP(20), EP300(14), MAP2K1(10), MAP3K7(1), MAPK3(1), SKIL(2), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(7) 8611661 84 61 79 42 47 8 3 14 12 0 0.880 1.000 1.000 406 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(21), CPT1A(10), LEP(2), LEPR(22), PRKAA1(1), PRKAA2(24), PRKAB1(2), PRKAB2(2), PRKAG1(2), PRKAG2(7) 4890702 93 60 87 47 65 5 4 6 13 0 0.585 1.000 1.000 407 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(16), GABRA2(15), GABRA3(19), GABRA4(12), GABRA5(2), GABRA6(22), GPX1(3), PRKCE(6) 2582029 95 59 83 49 71 5 3 9 6 1 0.276 1.000 1.000 408 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(1), ATG5(2), ATG7(8), BECN1(3), GABARAPL1(1), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(9), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(5), IFNA8(3), IFNG(2), PIK3C3(3), PIK3R4(6), PRKAA1(1), PRKAA2(24), ULK1(7), ULK2(6), ULK3(1) 6983276 108 59 104 57 76 7 6 13 6 0 0.429 1.000 1.000 409 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(3), IL6(2), IL6R(4), IL6ST(10), JAK1(6), JAK2(9), JAK3(6), JUN(1), MAP2K1(10), MAPK3(1), PTPN11(9), RAF1(8), SHC1(1), SOS1(8), SRF(2), STAT3(10) 7952718 97 59 90 46 44 12 4 25 12 0 0.735 1.000 1.000 410 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(4), FUCA1(2), GLB1(8), HEXA(5), HEXB(4), LCT(40), MAN2C1(3), MANBA(7), NEU1(7), NEU2(14), NEU3(3), NEU4(9) 5505885 106 59 104 52 79 9 2 11 5 0 0.255 1.000 1.000 411 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(15), AP2A1(1), AP2M1(3), BIN1(4), CALM1(1), CALM2(1), DNM1(8), EPN1(6), EPS15(3), PICALM(1), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYNJ1(20), SYNJ2(15), SYT1(19) 7152216 108 59 103 53 76 9 2 16 5 0 0.386 1.000 1.000 412 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(2), ALDOB(12), ALDOC(3), FBP1(2), FBP2(2), GOT1(6), GOT2(5), GPT(3), GPT2(1), MDH1(1), MDH2(4), ME1(19), ME2(1), ME3(9), PGK1(4), PKLR(11), PKM2(5), TKT(6) 6057530 96 58 93 49 68 8 5 7 8 0 0.0980 1.000 1.000 413 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CD3D(5), CD3E(2), CD3G(1), CD80(4), CD86(19), CTLA4(2), GRB2(2), HLA-DRA(11), HLA-DRB1(3), ICOS(3), IL2(4), ITK(20), LCK(12), PIK3CA(8), PIK3R1(3), PTPN11(9) 4276366 109 58 104 42 73 8 1 15 11 1 0.177 1.000 1.000 414 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 29 ANPEP(17), G6PD(3), GCLC(5), GCLM(2), GGT1(6), GPX1(3), GPX3(3), GPX5(12), GSS(7), GSTA1(5), GSTA2(2), GSTA3(1), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTP1(2), GSTT1(1), IDH2(2), MGST1(2), MGST2(2), MGST3(1), PGD(7) 5751479 99 58 96 48 66 6 6 14 7 0 0.0611 1.000 1.000 415 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(5), BHMT(8), CBS(6), CTH(1), DNMT1(18), DNMT3A(5), DNMT3B(9), MARS(6), MARS2(4), MAT1A(5), MAT2B(2), MTAP(4), MTFMT(2), MTR(9), TAT(17) 7024338 101 58 99 40 65 6 8 12 10 0 0.0494 1.000 1.000 416 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(3), CAT(5), EPX(7), LPO(18), MPO(11), MTHFR(1), PRDX6(4), SHMT1(1), SHMT2(2), TPO(40) 3913525 92 58 89 53 72 8 1 7 4 0 0.206 1.000 1.000 417 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(17), FOS(2), GRB2(2), HRAS(3), IL3(3), IL3RA(7), JAK2(9), MAP2K1(10), MAPK3(1), PTPN6(3), RAF1(8), SHC1(1), SOS1(8), STAT5A(2), STAT5B(4) 5870810 80 58 75 40 47 4 4 14 11 0 0.564 1.000 1.000 418 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), ASNS(8), CA1(8), CA12(3), CA2(9), CA3(5), CA4(3), CA5A(2), CA5B(1), CA6(4), CA7(1), CA8(4), CA9(8), CPS1(21), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUL(2), HAL(12) 6302036 100 58 98 44 69 6 3 13 9 0 0.148 1.000 1.000 419 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 9 ESR1(5), ESR2(6), PDE1B(12), PLCB1(48), PLCB2(9), PRL(1), TRH(4), VIP(4) 3291752 89 58 83 49 74 1 2 6 6 0 0.225 1.000 1.000 420 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(11), APOA1(2), APOA4(7), APOC1(2), APOC2(1), APOE(1), CETP(7), CYP7A1(8), DGAT1(1), HMGCR(12), LDLR(14), LIPC(8), LPL(3), LRP1(31), SCARB1(4), SOAT1(3) 9257646 115 58 113 66 68 13 7 15 12 0 0.443 1.000 1.000 421 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(5), ALOX15(8), ALOX15B(8), ALOX5(8), ALOX5AP(1), DPEP1(4), GGT1(6), LTA4H(4), PLA2G2A(2), PLA2G6(9), PTGDS(2), PTGIS(12), PTGS1(17), PTGS2(10), TBXAS1(11) 4989446 107 57 104 68 77 9 2 11 8 0 0.258 1.000 1.000 422 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(3), GSR(2), GSS(7), IL8(1), NFKB1(7), NOX1(11), RELA(4), TNF(1), XDH(50) 3303517 86 57 83 39 66 6 4 7 3 0 0.0488 1.000 1.000 423 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(6), BIRC2(5), BIRC3(7), CASP10(4), CASP3(2), CASP7(4), CASP8(8), CASP9(3), DFFA(2), DFFB(3), GZMB(3), PRF1(11), SCAP(8), SREBF1(5), SREBF2(8) 6091199 79 57 77 38 47 7 7 11 7 0 0.408 1.000 1.000 424 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(12), ATM(12), BRCA1(9), CDKN1A(4), CHEK1(2), CHEK2(2), JUN(1), MAPK8(1), MDM2(3), MRE11A(5), NFKB1(7), NFKBIA(2), RAD50(5), RBBP8(3), RELA(4), TP73(5) 9654554 77 56 76 37 35 12 3 17 10 0 0.828 1.000 1.000 425 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(3), APAF1(6), ATM(12), BAX(3), BCL2(2), CASP3(2), CASP7(4), CASP9(3), CYCS(1), EIF2S1(1), PRKCA(10), PTK2(8), PXN(3), STAT1(4), TLN1(12) 8859608 74 56 72 35 39 10 4 12 9 0 0.496 1.000 1.000 426 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(2), ALDOB(12), ALDOC(3), FBP1(2), FBP2(2), G6PD(3), GPI(3), H6PD(5), PFKM(1), PGD(7), PGLS(1), PGM1(4), PGM3(1), PRPS1(2), PRPS1L1(13), PRPS2(3), RBKS(4), TAL1(6), TALDO1(3), TKT(6) 6828679 83 56 80 60 54 7 5 6 11 0 0.756 1.000 1.000 427 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(3), BIRC2(5), BIRC3(7), CASP3(2), CASP8(8), CFLAR(4), JUN(1), MAP2K4(4), MAP3K3(6), MAP3K7(1), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), NR2C2(2), RALBP1(2), RIPK1(1), TNF(1), TNFAIP3(2), TNFRSF1A(3), TNFRSF1B(3), TRAF2(2) 9040643 78 56 78 49 39 6 9 18 6 0 0.928 1.000 1.000 428 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(19), HLA-DRA(11), HLA-DRB1(3), IFNG(2), IFNGR1(4), IFNGR2(4), IL12A(3), IL12B(3), IL12RB1(15), IL12RB2(3), IL18(2), IL18R1(17), IL2(4), IL2RA(4), IL4(1), IL4R(13) 4235648 109 56 105 46 80 6 0 9 14 0 0.0898 1.000 1.000 429 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(11), POLR1B(8), POLR1C(1), POLR2A(11), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(4), POLR3B(15), POLR3G(1), POLR3GL(1), POLR3H(1), POLR3K(1) 7866598 75 55 74 32 42 8 6 12 7 0 0.243 1.000 1.000 430 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 21 AKT1(3), CCND1(1), CCNE1(4), CDK4(5), CDK6(2), CDKN1A(4), CDKN1B(1), E2F1(5), HRAS(3), MAPK1(4), MAPK3(1), NFKB1(7), NFKBIA(2), PAK1(4), PIK3CA(8), PIK3R1(3), RAF1(8), RB1(8), RELA(4), TFDP1(2) 6593952 79 55 77 36 34 7 6 17 12 3 0.435 1.000 1.000 431 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(3), CHRNB1(1), CHRNG(2), MUSK(33), PIK3CA(8), PIK3R1(3), PTK2(8), PTK2B(10), RAPSN(1), SRC(1), TERT(6) 5435909 76 54 72 64 51 4 1 14 5 1 0.981 1.000 1.000 432 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(4), ALG5(2), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT5(2), DDOST(2), DPAGT1(2), DPM1(1), FUT8(8), MAN1A1(15), MAN1B1(4), MGAT1(3), MGAT2(2), MGAT3(10), MGAT4A(8), MGAT4B(1), MGAT5(4), RPN2(2), ST6GAL1(5) 6688657 81 54 80 50 51 9 3 10 8 0 0.668 1.000 1.000 433 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 14 CCR5(7), CD3D(5), CD3E(2), CD3G(1), CD4(6), CXCR3(4), IFNG(2), IL12A(3), IL12B(3), IL12RB1(15), IL12RB2(3), JAK2(9), STAT4(22), TYK2(7) 4620334 89 54 87 52 56 9 4 11 9 0 0.644 1.000 1.000 434 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 20 AKT1(3), CASP9(3), CDC42(2), CHUK(2), ELK1(2), H2AFX(2), HRAS(3), MAP2K1(10), MAPK3(1), NFKB1(7), PIK3CA(8), PIK3R1(3), RAF1(8), RALA(1), RALBP1(2), RALGDS(8), RELA(4), RHOA(1) 6173856 70 54 64 41 38 10 2 15 4 1 0.848 1.000 1.000 435 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(5), CD3E(2), CD3G(1), CD4(6), FYN(6), HLA-DRA(11), HLA-DRB1(3), LCK(12), PTPRC(30), ZAP70(7) 2953976 83 54 80 36 57 8 1 9 8 0 0.118 1.000 1.000 436 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 DNAJA3(4), IFNG(2), IFNGR1(4), IFNGR2(4), IKBKB(3), JAK2(9), NFKB1(7), NFKBIA(2), RB1(8), RELA(4), TNF(1), TNFRSF1A(3), TNFRSF1B(3), USH1C(18), WT1(5) 5627065 77 54 74 33 35 6 4 13 17 2 0.400 1.000 1.000 437 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(6), CREBBP(20), EP300(14), NCOA3(14), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RARA(3), RXRA(4) 6930703 83 53 83 45 52 4 4 14 9 0 0.827 1.000 1.000 438 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(6), ARHGDIB(3), BIRC2(5), BIRC3(7), CASP1(4), CASP10(4), CASP2(1), CASP3(2), CASP4(1), CASP7(4), CASP8(8), CASP9(3), CYCS(1), DFFA(2), DFFB(3), GZMB(3), LMNA(8), LMNB1(2), LMNB2(4), PRF1(11) 6551792 82 53 82 34 44 11 6 15 6 0 0.294 1.000 1.000 439 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(6), POLD2(2), POLE(15), POLG(8), POLL(7), POLQ(23) 5596894 61 53 60 26 33 5 2 12 9 0 0.256 1.000 1.000 440 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(4), CYSLTR2(2), GPR109B(7), GPR161(7), GPR171(9), GPR18(5), GPR34(2), GPR39(10), GPR45(6), GPR65(10), GPR68(3), GPR75(5), GPR81(4) 3269975 74 53 72 37 53 3 4 6 8 0 0.00728 1.000 1.000 441 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(2), B4GALNT1(3), GLB1(8), HEXA(5), HEXB(4), LCT(40), SLC33A1(5), ST3GAL1(6), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(5), ST6GALNAC4(1), ST6GALNAC5(7), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(9) 5516662 101 53 99 62 72 9 1 13 6 0 0.581 1.000 1.000 442 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 18 AKT1(3), EIF2B5(1), EIF2S1(1), EIF4EBP1(1), GSK3B(2), IGF1(11), IGF1R(10), INPPL1(15), PDK2(4), PDPK1(4), PIK3CA(8), PIK3R1(3), PPP2CA(1), RPS6(1), RPS6KB1(2) 6309702 67 53 64 35 39 8 5 8 6 1 0.630 1.000 1.000 443 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(4), CASP2(1), CHUK(2), CRADD(1), IKBKB(3), JUN(1), LTA(2), MAP2K3(7), MAP2K4(4), MAP2K6(3), MAP3K1(2), MAP3K14(3), MAP4K2(6), MAPK14(5), MAPK8(1), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), TNF(1), TNFRSF1A(3), TRAF2(2) 7951248 65 53 65 45 37 10 2 10 6 0 0.924 1.000 1.000 444 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(13), CCND1(1), CCND2(5), CCND3(2), CCNE1(4), CCNH(2), CDC25A(8), CDK4(5), CDK6(2), CDKN1A(4), CDKN1B(1), CDKN2C(1), E2F1(5), RB1(8), RBL1(10), TFDP1(2) 5208176 73 52 72 23 40 3 6 14 8 2 0.0243 1.000 1.000 445 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), ELK1(2), EPO(5), EPOR(1), FOS(2), GRB2(2), HRAS(3), JAK2(9), JUN(1), MAP2K1(10), MAPK3(1), MAPK8(1), PLCG1(9), PTPN6(3), RAF1(8), SHC1(1), SOS1(8), STAT5A(2), STAT5B(4) 7124992 73 52 68 39 38 5 6 16 8 0 0.782 1.000 1.000 446 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(3), CAT(5), GH1(3), GHR(25), HRAS(3), IGF1(11), IGF1R(10), PIK3CA(8), PIK3R1(3), SHC1(1) 4439322 72 52 68 38 50 9 0 8 4 1 0.556 1.000 1.000 447 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(21), CD38(4), ENPP1(11), ENPP3(14), NADSYN1(4), NMNAT2(3), NNMT(9), NNT(3), NT5E(4), NT5M(2), QPRT(6) 4881343 81 52 77 38 51 8 4 9 9 0 0.317 1.000 1.000 448 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(20), EP300(14), LPL(3), NCOA1(9), NCOA2(13), PPARG(11), RXRA(4) 6228414 74 52 72 29 49 4 3 11 7 0 0.374 1.000 1.000 449 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(26), FHL5(12), FSHB(4), FSHR(15), GNAS(19), XPO1(2) 3165348 78 51 75 50 58 5 4 5 6 0 0.843 1.000 1.000 450 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(7), ASPH(3), COPS5(3), EDN1(8), EP300(14), EPO(5), HIF1A(5), JUN(1), LDHA(5), NOS3(16), P4HB(2), VHL(4) 5725124 73 51 71 32 45 3 5 10 10 0 0.469 1.000 1.000 451 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(3), GRB2(2), HRAS(3), IGF1R(10), IRS1(5), MAP2K1(10), MAPK1(4), MAPK3(1), PIK3CA(8), PIK3R1(3), RAF1(8), SHC1(1), SOS1(8) 6366236 66 51 60 31 36 8 2 12 7 1 0.565 1.000 1.000 452 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 10 CD28(1), CD3D(5), CD3E(2), CD3G(1), CD8A(2), ICAM1(2), ITGAL(24), ITGB2(13), PTPRC(30), THY1(1) 3307115 81 51 78 42 56 5 2 5 13 0 0.200 1.000 1.000 453 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 10 CD28(1), CD3D(5), CD3E(2), CD3G(1), CD4(6), ICAM1(2), ITGAL(24), ITGB2(13), PTPRC(30), THY1(1) 3478666 85 51 82 48 58 6 2 6 13 0 0.323 1.000 1.000 454 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(3), BCL2(2), CASP8(8), CYCS(1), MAP2K1(10), MAP2K4(4), MAP3K1(2), MAPK1(4), MAPK3(1), MAPK8(1), NFKB1(7), NSMAF(4), RAF1(8), RELA(4), RIPK1(1), SMPD1(3), TNFRSF1A(3), TRAF2(2) 6817640 68 50 63 31 38 6 3 13 8 0 0.504 1.000 1.000 455 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(21), ACACB(17), FASN(17), MCAT(2), OLAH(11), OXSM(2) 5287659 70 50 69 37 43 6 3 9 9 0 0.295 1.000 1.000 456 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(6), CSF1(10), CSF2(2), CSF3(4), HLA-DRA(11), HLA-DRB1(3), IFNA1(1), IFNB1(6), IFNG(2), IL10(3), IL11(2), IL12A(3), IL12B(3), IL13(2), IL15(3), IL1A(4), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(5), IL8(1), LTA(2), PDGFA(1), TGFB1(1), TGFB2(1), TGFB3(3), TNF(1) 4398114 94 50 93 49 63 7 3 9 12 0 0.0504 1.000 1.000 457 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(5), BHMT(8), CBS(6), CTH(1), DNMT1(18), DNMT3A(5), DNMT3B(9), MARS(6), MARS2(4), MAT1A(5), MAT2B(2), MTR(9) 5913932 78 50 77 26 49 4 7 10 8 0 0.0158 1.000 1.000 458 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(1), APC(19), AXIN1(10), BTRC(4), CTNNB1(11), DLL1(2), FZD1(4), GSK3B(2), NOTCH1(5), PSEN1(1), WNT1(2) 7051430 61 50 61 38 29 7 4 7 14 0 0.921 1.000 1.000 459 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 AKT1(3), AP2A1(1), AP2M1(3), BTK(15), EEA1(2), GRASP(1), GSK3B(2), LYN(6), PDPK1(4), PFKL(4), PFKM(1), PLCG1(9), PRKCE(6), PRKCZ(5), RAB5A(1), RPS6KB1(2), VAV2(3) 8126485 68 50 66 44 38 5 5 10 10 0 0.672 1.000 1.000 460 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 ATM(12), CDC25A(8), CDC25B(4), CDC25C(4), CDK4(5), CHEK1(2), MYT1(21), RB1(8), WEE1(2) 5612849 66 50 63 26 35 5 2 11 11 2 0.350 1.000 1.000 461 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(3), IL6(2), IL6R(4), JAK1(6), JAK2(9), JAK3(6), PIAS3(5), PTPRU(15), REG1A(7), SRC(1), STAT3(10) 5079781 68 50 68 40 37 6 3 12 10 0 0.659 1.000 1.000 462 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(5), GNAQ(4), HTR2C(10), PLCB1(48), TUB(9) 2391755 76 50 71 36 62 1 1 7 5 0 0.129 1.000 1.000 463 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(1), ALDH18A1(7), ARG1(1), ARG2(1), ASL(6), CKM(2), CKMT1A(1), CKMT2(5), CPS1(21), GAMT(4), GATM(5), GLUD1(2), NAGS(1), OAT(3), ODC1(3), OTC(3), PYCR1(1), SMS(5) 5779297 72 50 70 31 42 8 3 10 9 0 0.153 1.000 1.000 464 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 17 ACTA1(4), ACTR2(3), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), NCK1(1), NCKAP1(5), NTRK1(15), PIR(1), WASF1(4), WASF2(4), WASF3(12), WASL(5) 4986202 62 49 61 27 40 5 2 8 7 0 0.525 1.000 1.000 465 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 19 ACO1(5), ACO2(4), CS(2), DLD(2), FH(3), IDH2(2), IDH3A(3), IDH3B(1), IDH3G(2), MDH1(1), MDH2(4), PC(12), PCK1(23), SDHA(1), SDHB(1), SUCLG1(2), SUCLG2(2) 6657216 70 49 67 45 50 1 6 7 6 0 0.724 1.000 1.000 466 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(11), CYP11A1(13), CYP11B2(13), CYP17A1(7), HSD11B1(11), HSD11B2(2), HSD3B1(10), HSD3B2(10) 2308336 77 49 73 51 57 6 1 6 7 0 0.122 1.000 1.000 467 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(5), ACOX1(7), ACOX3(11), ELOVL2(2), ELOVL5(1), ELOVL6(2), FADS2(3), FASN(17), HADHA(8), HSD17B12(2), PECR(1), SCD(3) 4781218 62 49 62 29 40 4 2 9 7 0 0.0857 1.000 1.000 468 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(1), DPM2(1), ELK1(2), FOS(2), GRB2(2), HRAS(3), JUN(1), KLK2(2), MAP2K1(10), MAPK3(1), MAPK8(1), NGFR(7), PIK3CA(8), PIK3R1(3), PLCG1(9), RAF1(8), SHC1(1), SOS1(8) 6362295 70 49 64 35 40 7 2 15 5 1 0.722 1.000 1.000 469 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(35), AKT1(3), ATM(12), BAX(3), CDKN1A(4), CPB2(1), CSNK1A1(2), CSNK1D(1), HIC1(1), HIF1A(5), IGFBP3(2), MAPK8(1), MDM2(3), NFKBIB(1), NQO1(1) 6683490 75 49 69 41 43 8 2 12 10 0 0.854 1.000 1.000 470 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(19), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), FDXR(8), SHMT1(1) 5371570 77 49 76 43 43 4 6 14 10 0 0.486 1.000 1.000 471 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(3), CASP9(3), CHUK(2), GH1(3), GHR(25), NFKB1(7), NFKBIA(2), PDPK1(4), PIK3CA(8), PIK3R1(3), PPP2CA(1), RELA(4) 4679510 65 48 61 38 43 6 3 8 4 1 0.832 1.000 1.000 472 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(19), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), SHMT1(1) 5049345 69 48 68 39 38 3 6 13 9 0 0.546 1.000 1.000 473 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM2(1), CCL2(1), CCR5(7), CXCL12(2), CXCR4(3), FOS(2), GNAQ(4), JUN(1), MAPK14(5), MAPK8(1), PLCG1(9), PRKCA(10), PTK2B(10), SYT1(19) 4632368 76 48 71 54 50 6 4 11 5 0 0.834 1.000 1.000 474 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(3), GRB2(2), HRAS(3), MAPK1(4), MAPK3(1), MAPK7(4), MEF2A(5), MEF2B(2), MEF2C(2), MEF2D(4), NTRK1(15), PIK3CA(8), PIK3R1(3), PLCG1(9), RPS6KA1(6), SHC1(1) 6318731 72 48 68 53 45 10 2 7 7 1 0.966 1.000 1.000 475 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(19), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), SHMT1(1) 5049345 69 48 68 39 38 3 6 13 9 0 0.546 1.000 1.000 476 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(6), B3GAT2(2), B3GAT3(4), CHPF(3), CHST11(5), CHST12(4), CHST13(3), CHST14(3), CHST3(1), CHSY1(8), DSE(18), XYLT1(10), XYLT2(3) 4439467 70 48 70 46 47 9 3 7 4 0 0.461 1.000 1.000 477 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(7), ACOX3(11), FADS2(3), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9) 3390359 78 48 78 42 56 5 1 5 11 0 0.241 1.000 1.000 478 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(6), DHRS1(3), DHRS2(6), DHRS3(4), DHRS7(1), DHRSX(4), HEMK1(4), LCMT1(4), METTL2B(7), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), WBSCR22(1) 5049976 66 48 65 33 38 9 2 13 4 0 0.366 1.000 1.000 479 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(1), ACOT11(6), DHRS1(3), DHRS2(6), DHRS3(4), DHRS7(1), DHRSX(4), ECHS1(2), EHHADH(6), ESCO1(1), ESCO2(2), GCDH(5), HADHA(8), MYST3(15), MYST4(14), NAT6(2), PNPLA3(2), SH3GLB1(2), YOD1(1) 8743384 85 48 83 57 50 10 3 17 5 0 0.976 1.000 1.000 480 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(7), IL22(1), IL22RA1(11), IL22RA2(1), JAK1(6), JAK2(9), JAK3(6), SOCS3(2), STAT1(4), STAT3(10), STAT5A(2), STAT5B(4), TYK2(7) 6090468 70 48 70 43 36 6 7 14 7 0 0.823 1.000 1.000 481 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 15 AKT1(3), AKT2(8), AKT3(4), GRB2(2), MAPK1(4), MAPK3(1), PDK1(2), PIK3CA(8), PIK3CD(7), PTK2B(10), RBL2(4), SHC1(1), SOS1(8) 6606606 62 48 61 34 36 6 0 14 6 0 0.775 1.000 1.000 482 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(19), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), SHMT1(1) 5049345 69 48 68 39 38 3 6 13 9 0 0.546 1.000 1.000 483 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(5), CHUK(2), IFNG(2), IKBKB(3), IL2(4), IL4(1), JUN(1), MAP3K1(2), MAP3K5(16), MAP4K5(3), MAPK14(5), MAPK8(1), NFKB1(7), NFKBIA(2), RELA(4), TNFRSF9(4), TNFSF9(1), TRAF2(2) 6407070 65 47 62 33 38 5 1 12 9 0 0.658 1.000 1.000 484 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 13 ABL1(12), E2F1(5), MDM2(3), MYC(5), PIK3CA(8), PIK3R1(3), POLR1A(11), POLR1B(8), POLR1C(1), RB1(8), TBX2(6), TWIST1(1) 6158354 71 47 70 21 42 8 2 9 7 3 0.0169 1.000 1.000 485 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(4), ACADM(5), ACADS(4), ACADVL(1), ACSL1(4), ACSL3(6), ACSL4(2), CPT1A(10), CPT2(1), DCI(2), EHHADH(6), HADHA(8), PECR(1), SCP2(2), SLC25A20(1) 5687170 57 47 54 30 38 3 3 7 6 0 0.711 1.000 1.000 486 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(6), ATM(12), BAX(3), BCL2(2), CCND1(1), CCNE1(4), CDK4(5), CDKN1A(4), E2F1(5), MDM2(3), PCNA(2), RB1(8), TIMP3(5) 5757379 60 47 58 18 21 7 4 14 12 2 0.139 1.000 1.000 487 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(3), JAK1(6), JAK2(9), JAK3(6), PIAS1(5), PIAS3(5), PTPRU(15), REG1A(7), SOAT1(3) 4569654 59 47 59 28 37 4 2 8 8 0 0.335 1.000 1.000 488 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), GCK(17), GFPT1(4), GNE(3), HEXA(5), HEXB(4), HK1(3), HK2(12), HK3(13), PGM3(1), RENBP(3), UAP1(2) 5683967 68 46 65 38 46 5 2 8 7 0 0.517 1.000 1.000 489 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(35), CYP2C9(35) 675777 70 46 62 47 59 3 2 1 5 0 0.675 1.000 1.000 490 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(20), DAXX(9), HRAS(3), PAX3(3), PML(3), RARA(3), RB1(8), SP100(8), TNF(1), TNFRSF1A(3), TNFRSF1B(3) 6013662 64 46 64 28 28 8 6 11 9 2 0.420 1.000 1.000 491 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(7), F13B(23), HSD17B2(9), HSD17B3(5), HSD17B4(6), HSD17B7(1), HSD3B1(10), HSD3B2(10) 2678975 71 46 66 32 50 4 5 4 7 1 0.109 1.000 1.000 492 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(4), ARFGAP3(3), ARFGEF2(15), CLTA(1), CLTB(1), COPA(6), GBF1(12), GPLD1(20), KDELR3(1) 5491871 63 45 63 38 35 5 4 13 6 0 0.817 1.000 1.000 493 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM2(1), CAMK1(4), CAMK1G(9), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CAMK4(10), CAMKK1(3), CAMKK2(7), SYT1(19) 3889849 72 45 67 57 53 7 2 6 4 0 0.906 1.000 1.000 494 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ACTR2(3), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(2), PAK1(4), PDGFRA(27), PIK3CA(8), PIK3R1(3), WASL(5) 4363245 60 45 59 23 38 3 2 8 8 1 0.318 1.000 1.000 495 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GALNS(4), GLB1(8), GNS(2), GUSB(3), HEXA(5), HEXB(4), IDS(9), IDUA(4), LCT(40), NAGLU(4) 4783621 84 45 82 46 66 5 0 8 5 0 0.406 1.000 1.000 496 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(1), MRPS7(1), RPL10L(6), RPL11(2), RPL13A(2), RPL14(1), RPL18(3), RPL18A(1), RPL19(1), RPL21(1), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL36AL(1), RPL38(1), RPL39(1), RPL3L(3), RPL6(1), RPL7(2), RPS10(1), RPS11(1), RPS13(1), RPS16(1), RPS18(1), RPS2(2), RPS20(2), RPS23(1), RPS24(1), RPS27(1), RPS29(1), RPS3A(1), RPS5(1), RPS6(1), RPS7(4), RPS8(1), RPSA(1) 7542160 61 45 61 41 33 5 7 10 6 0 0.856 1.000 1.000 497 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(4), APAF1(6), BCL2(2), CASP3(2), CASP9(3), CYCS(1), DAXX(9), FAS(5), FASLG(14), HSPB1(2), HSPB2(1), IL1A(4), MAPKAPK2(5), MAPKAPK3(3), TNF(1) 3812619 62 45 62 29 39 4 3 8 8 0 0.264 1.000 1.000 498 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(27), MAP2(13), PPP1CA(1), PPP2CA(1), PRKACB(4), PRKACG(8), PRKAG1(2), PRKAR2A(1), PRKAR2B(5), PRKCE(6) 6055010 68 44 67 42 40 7 4 8 9 0 0.952 1.000 1.000 499 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), KHK(1), LCT(40), MPI(1), PGM1(4), PYGL(7), PYGM(10), TREH(3) 4416819 69 44 68 56 54 6 1 5 3 0 0.789 1.000 1.000 500 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(10), CD4(6), HLA-DRA(11), HLA-DRB1(3), IL1B(6), IL4(1), IL5(4), IL5RA(12), IL6(2) 1787952 56 44 53 33 43 1 1 5 6 0 0.221 1.000 1.000 501 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(2), MAP3K14(3), MAPK14(5), MAPK8(1), NFKB1(7), RELA(4), TNFRSF13B(8), TNFRSF17(6), TNFSF13B(1), TRAF2(2), TRAF3(5), TRAF5(7), TRAF6(4) 4808832 55 44 54 25 35 6 0 11 3 0 0.369 1.000 1.000 502 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(18), EGFR(22), ERBB3(5), NRG1(14), UBE2D1(1) 3462760 60 43 60 40 45 1 3 7 4 0 0.965 1.000 1.000 503 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(8), IL13(2), IL4(1), IL5(4), MAF(1), MAP2K3(7), MAPK14(5), NFATC1(15), NFATC2(9), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5) 4032673 74 43 72 47 51 8 3 5 7 0 0.601 1.000 1.000 504 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(14), AMT(1), ATIC(5), FTCD(2), GART(9), MTFMT(2), MTHFD1(10), MTHFD1L(1), MTHFD2(2), MTHFR(1), MTR(9), SHMT1(1), SHMT2(2), TYMS(1) 6348907 60 43 59 37 39 5 3 6 7 0 0.751 1.000 1.000 505 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(6), CLOCK(4), CRY1(7), CRY2(3), CSNK1D(1), CSNK1E(4), NPAS2(4), PER1(8), PER2(11), PER3(9) 5694130 57 43 54 41 37 6 1 4 9 0 0.962 1.000 1.000 506 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2), ECHS1(2), EHHADH(6), HADHA(8), SDS(2) 4058870 56 43 54 31 31 9 2 9 5 0 0.425 1.000 1.000 507 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(2), CREBBP(20), EP300(14), HDAC3(5), IKBKB(3), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF6(4) 7465499 69 43 69 35 40 7 5 12 5 0 0.661 1.000 1.000 508 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(3), DPM2(1), GRB2(2), HRAS(3), KLK2(2), NTRK1(15), PIK3CA(8), PIK3R1(3), PLCG1(9), PRKCA(10), SHC1(1), SOS1(8) 5202210 65 43 63 33 40 8 2 9 5 1 0.645 1.000 1.000 509 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(12), CDC25A(8), CDC25B(4), CDC25C(4), CHEK1(2), MYT1(21), WEE1(2) 4612621 53 42 51 25 34 5 1 6 7 0 0.601 1.000 1.000 510 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(6), CHPT1(1), HEMK1(4), LCMT1(4), METTL2B(7), METTL6(2), PCYT1A(3), PCYT1B(7), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), WBSCR22(1) 4704823 59 42 58 24 34 7 4 10 4 0 0.149 1.000 1.000 511 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(2), B3GNT2(2), B3GNT7(4), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), CHST1(9), CHST2(4), CHST4(9), CHST6(4), FUT8(8), ST3GAL1(6), ST3GAL2(1), ST3GAL3(1), ST3GAL4(1) 4165088 60 42 59 38 39 12 4 2 3 0 0.448 1.000 1.000 512 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 15 AKT1(3), BCAR1(4), CDKN1B(1), GRB2(2), ITGB1(4), MAPK1(4), MAPK3(1), PDK2(4), PDPK1(4), PIK3CA(8), PIK3R1(3), PTK2(8), SHC1(1), SOS1(8) 6146858 55 42 53 30 34 5 0 10 5 1 0.840 1.000 1.000 513 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNB1(6), JAK1(6), PTPRU(15), REG1A(7), STAT1(4), STAT2(8), TYK2(7) 4197615 55 42 55 28 29 4 2 10 10 0 0.397 1.000 1.000 514 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(18), AOC2(7), AOC3(8), CES1(16), ESD(2) 2014132 51 41 49 34 41 2 4 2 2 0 0.622 1.000 1.000 515 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), CYP51A1(1), DHCR24(1), DHCR7(9), FDPS(3), GGCX(3), GGPS1(1), HMGCR(12), HSD17B7(1), IDI1(1), IDI2(1), LSS(2), MVD(1), MVK(2), NQO1(1), NSDHL(3), PMVK(2), SC4MOL(3), SC5DL(2), SQLE(4), TM7SF2(4) 6454179 58 41 56 31 26 11 4 10 7 0 0.533 1.000 1.000 516 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(6), ARHGAP5(11), ARHGDIB(3), CASP1(4), CASP10(4), CASP3(2), CASP8(8), CASP9(3), CYCS(1), GZMB(3), JUN(1), PRF1(11) 4333637 57 40 56 28 36 6 3 9 3 0 0.642 1.000 1.000 517 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(2), EGF(18), EGFR(22), HGS(3), RAB5A(1), TF(11), TFRC(4) 4297461 61 40 61 41 43 2 4 8 4 0 0.946 1.000 1.000 518 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 20 ABO(5), B3GNT1(2), B3GNT2(2), B3GNT3(6), B3GNT4(3), B3GNT5(1), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), FUT1(3), FUT2(3), FUT3(4), FUT4(2), FUT5(6), FUT6(4), FUT7(2), ST3GAL6(2), ST8SIA1(1) 5105704 55 40 54 33 33 8 3 3 8 0 0.443 1.000 1.000 519 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(4), CAMK1G(9), HDAC9(38), MEF2A(5), MEF2B(2), MEF2C(2), MEF2D(4), MYOD1(1) 2478754 65 40 57 32 52 5 0 3 5 0 0.326 1.000 1.000 520 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(14), AMT(1), ATIC(5), GART(9), MTHFD1(10), MTHFD1L(1), MTHFD2(2), MTHFR(1), MTR(9), SHMT1(1), SHMT2(2), TYMS(1) 5995111 56 40 55 32 36 5 3 6 6 0 0.597 1.000 1.000 521 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(6), IFNG(2), IL10(3), IL12A(3), IL12B(3), IL13(2), IL15(3), IL16(12), IL18(2), IL1A(4), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL8(1), IL9(1), LTA(2), TNF(1) 3306170 60 39 59 34 41 3 3 4 9 0 0.229 1.000 1.000 522 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(7), CDKN1A(4), EPO(5), EPOR(1), GRIN1(7), HIF1A(5), JAK2(9), NFKB1(7), NFKBIA(2), RELA(4) 4194201 51 39 51 23 21 5 5 10 10 0 0.575 1.000 1.000 523 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(7), ANKRD1(1), CYR61(1), DUSP14(2), EIF4EBP1(1), HBEGF(1), IFNG(2), IFRD1(2), IL18(2), IL1A(4), IL1R1(11), JUND(1), MYOG(3), NR4A3(7), WDR1(4) 3557358 49 39 47 23 31 5 2 4 7 0 0.451 1.000 1.000 524 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(20), EP300(14), ESR1(5), MAPK1(4), MAPK3(1), PELP1(10), SRC(1) 4908328 55 39 55 29 36 3 3 9 4 0 0.702 1.000 1.000 525 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(5), CBS(6), CTH(1), GGT1(6), MARS(6), MARS2(4), MAT1A(5), MAT2B(2), PAPSS1(3), PAPSS2(5), SCLY(3), SEPHS1(4) 4180628 50 39 50 21 31 4 3 7 5 0 0.118 1.000 1.000 526 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(10), CYP2E1(13), NR1I3(7), PTGS1(17), PTGS2(10) 1806954 57 38 55 31 42 4 1 4 6 0 0.203 1.000 1.000 527 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(3), GNAS(19), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10) 3165103 54 38 52 39 42 4 2 2 4 0 0.944 1.000 1.000 528 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(5), ACO2(4), AFMID(2), CS(2), GRHPR(2), HAO1(7), HAO2(11), HYI(1), MDH1(1), MDH2(4), MTHFD1(10), MTHFD1L(1), MTHFD2(2) 4489553 52 38 49 27 30 4 4 6 8 0 0.355 1.000 1.000 529 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), BLVRB(1), HMOX1(1), IL10(3), IL10RA(7), IL10RB(5), IL1A(4), IL6(2), JAK1(6), STAT1(4), STAT3(10), STAT5A(2), TNF(1) 4089982 48 38 47 26 22 5 6 7 8 0 0.479 1.000 1.000 530 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), GRB2(2), IL2RG(3), IL4(1), IL4R(13), IRS1(5), JAK1(6), JAK3(6), RPS6KB1(2), SHC1(1), STAT6(7) 4937568 49 38 49 26 28 6 3 5 7 0 0.503 1.000 1.000 531 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(3), CREBBP(20), DFFA(2), DFFB(3), GZMA(11), GZMB(3), HMGB2(1), PRF1(11), SET(3) 3553310 57 38 55 19 33 4 5 10 5 0 0.115 1.000 1.000 532 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(2), IKBKAP(5), IKBKB(3), LTA(2), MAP3K1(2), MAP3K14(3), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), TNFAIP3(2), TNFRSF1B(3), TRAF1(6), TRAF2(2), TRAF3(5) 7459302 49 38 49 47 31 6 1 6 5 0 0.999 1.000 1.000 533 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(6), CHAT(14), CHKA(2), PCYT1A(3), PDHA1(3), PDHA2(17), PEMT(2), SLC18A3(2) 2296468 49 37 46 23 39 5 0 2 3 0 0.0943 1.000 1.000 534 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 FOS(2), JUN(1), MAPK3(1), OPRK1(21), POLR2A(11), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5) 4294432 58 37 58 54 45 3 3 3 4 0 0.987 1.000 1.000 535 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(8), DHRS1(3), DHRS2(6), DHRS3(4), DHRS7(1), DHRSX(4), HSD3B7(3), PON1(14), PON2(1), PON3(5), RDH11(2), RDH12(2), RDH13(3) 3030336 56 37 54 29 39 4 1 7 5 0 0.249 1.000 1.000 536 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(2), FOSL2(5), IFNAR1(2), IFNAR2(7), IFNB1(6), MAPK8(1), NFKB1(7), RELA(4), TNFRSF11A(5), TNFSF11(4), TRAF6(4) 3708288 47 37 46 24 30 3 0 9 5 0 0.635 1.000 1.000 537 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), LDLR(14), MBTPS1(9), MBTPS2(1), SCAP(8), SREBF1(5), SREBF2(8) 3968538 47 37 45 25 30 2 3 8 4 0 0.468 1.000 1.000 538 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(1), DHCR7(9), FDPS(3), HMGCR(12), HMGCS1(2), IDI1(1), LSS(2), MVD(1), MVK(2), NSDHL(3), PMVK(2), SC4MOL(3), SC5DL(2), SQLE(4) 4409973 47 36 45 22 21 8 2 10 6 0 0.493 1.000 1.000 539 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(5), ACO2(4), CS(2), GRHPR(2), HAO1(7), HAO2(11), HYI(1), MDH1(1), MDH2(4), MTHFD1(10), MTHFD1L(1), MTHFD2(2) 4286373 50 36 47 23 29 4 3 6 8 0 0.221 1.000 1.000 540 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(10), CDO1(5), CSAD(4), GAD1(13), GAD2(7), GGT1(6) 1895413 45 36 44 25 30 4 4 5 2 0 0.448 1.000 1.000 541 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(17), HK1(3), HK2(12), HK3(13), IMPA1(1), IMPA2(2), ISYNA1(1), PGM1(4), PGM3(1), TGDS(1) 3900255 55 36 53 35 40 5 1 4 5 0 0.539 1.000 1.000 542 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), BET1L(1), BNIP1(1), GOSR1(1), SEC22B(5), SNAP25(6), SNAP29(1), STX10(1), STX11(1), STX12(1), STX16(2), STX17(1), STX19(2), STX2(4), STX3(2), STX5(4), STX6(1), TSNARE1(4), VAMP1(1), VAMP3(1), VAMP4(1), VAMP7(5), VAMP8(1), VTI1A(1), VTI1B(1) 5540826 50 36 47 26 28 5 1 9 7 0 0.492 1.000 1.000 543 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(3), IFNG(2), IFNGR1(4), JAK1(6), JAK2(9), PLA2G2A(2), PTPRU(15), REG1A(7), STAT1(4) 3823924 52 36 52 22 30 2 1 9 10 0 0.339 1.000 1.000 544 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(2), IKBKAP(5), IKBKB(3), MAP3K1(2), MAP3K14(3), NFKB1(7), NFKBIA(2), RELA(4), TNFAIP3(2), TRAF3(5), TRAF6(4) 6040771 39 35 39 33 23 6 1 6 3 0 0.990 1.000 1.000 545 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), HS3ST1(10), HS3ST2(7), HS3ST3A1(4), HS3ST3B1(2), XYLT1(10), XYLT2(3) 2125078 40 35 40 37 25 5 1 5 4 0 0.907 1.000 1.000 546 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), HS3ST1(10), HS3ST2(7), HS3ST3A1(4), HS3ST3B1(2), XYLT1(10), XYLT2(3) 2125078 40 35 40 37 25 5 1 5 4 0 0.907 1.000 1.000 547 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(5), CHST12(4), CHST13(3), PAPSS1(3), PAPSS2(5), SULT1A1(12), SULT1A2(2), SULT1E1(12), SULT2A1(7), SULT2B1(6), SUOX(4) 3049991 63 35 61 35 51 3 0 4 5 0 0.338 1.000 1.000 548 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(8), POLR2A(11), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(2) 4477860 42 35 41 16 25 4 2 6 5 0 0.142 1.000 1.000 549 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(17), CKM(2), FBL(1), GPT(3), LDHA(5), LDHB(2), LDHC(5), MAPK14(5), NCL(6) 3010319 46 35 45 22 32 2 4 5 3 0 0.358 1.000 1.000 550 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(3), IL13RA2(3), IL4R(13), JAK1(6), JAK2(9), TYK2(7) 3501773 43 35 43 21 26 2 2 8 5 0 0.605 1.000 1.000 551 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(2), IL13RA1(3), IL13RA2(3), IL4R(13), JAK1(6), JAK2(9), TYK2(7) 3501773 43 35 43 21 26 2 2 8 5 0 0.605 1.000 1.000 552 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(2), CD36(4), FOS(2), FYN(6), JUN(1), MAPK14(5), THBS1(27) 2480709 47 35 47 27 28 1 2 7 9 0 0.775 1.000 1.000 553 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(3), DHRS2(6), DHRS3(4), DHRS7(1), DHRSX(4), ESCO1(1), ESCO2(2), MYST3(15), MYST4(14), NAT6(2), PNPLA3(2), SH3GLB1(2) 5581995 56 34 55 41 32 7 1 12 4 0 0.992 1.000 1.000 554 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(17), HK1(3), HK2(12), HK3(13), IMPA1(1), PGM1(4), PGM3(1), TGDS(1) 3428477 52 34 50 30 39 5 1 3 4 0 0.400 1.000 1.000 555 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(26), GNAS(19), PRKACA(3), PRKAR1A(1) 2172718 49 33 47 26 32 5 3 4 5 0 0.394 1.000 1.000 556 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(12), ATR(20), CDC25C(4), CHEK1(2), CHEK2(2) 5080244 40 32 39 21 26 2 2 5 5 0 0.862 1.000 1.000 557 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(19), GNA12(3), PRKACB(4), PRKACG(8), PRKAG1(2), PRKAR2A(1), PRKAR2B(5) 3379191 42 31 42 26 30 3 1 5 3 0 0.771 1.000 1.000 558 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 13 A4GALT(5), B3GALNT1(6), B3GALT5(1), FUT1(3), FUT2(3), GBGT1(2), GLA(1), HEXA(5), HEXB(4), NAGA(3), ST3GAL1(6), ST3GAL2(1), ST8SIA1(1) 3367220 41 31 40 32 26 4 2 5 4 0 0.857 1.000 1.000 559 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(2), IFNAR2(7), IFNB1(6), JAK1(6), STAT1(4), STAT2(8), TYK2(7) 3610515 41 31 41 19 21 3 2 9 6 0 0.450 1.000 1.000 560 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 12 CD34(4), CD3D(5), CD3E(2), CD3G(1), CD4(6), CD58(1), CD8A(2), CSF3(4), IL3(3), IL6(2), IL8(1), KITLG(8) 1812386 39 31 38 23 28 2 2 5 2 0 0.458 1.000 1.000 561 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(9), CAPN1(4), CAPNS1(1), CDK5(4), CSNK1A1(2), CSNK1D(1), GSK3B(2), MAPT(10), PPP2CA(1) 3012036 34 31 34 16 22 2 2 3 5 0 0.349 1.000 1.000 562 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(9), FDPS(3), HMGCR(12), IDI1(1), LSS(2), MVD(1), MVK(2), NQO1(1), PMVK(2), SC5DL(2), SQLE(4) 3690312 39 30 37 20 16 6 2 10 5 0 0.625 1.000 1.000 563 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(5), PSMA2(1), PSMA4(1), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC2(2), PSMC3(4), PSMD1(5), PSMD12(1), PSMD13(3), PSMD2(3) 5410945 39 30 38 19 22 4 2 8 3 0 0.685 1.000 1.000 564 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(4), NRF1(4), UBE2D1(1), UBE2D3(3), UBE2E1(1), UBE2E3(1), UBE2G2(1), UBE2H(1), UBE2I(2), UBE2J1(2), UBE2J2(6), UBE2L6(2), UBE2M(1), UBE2S(2), UBE3A(6) 3546056 37 30 36 17 24 5 1 5 2 0 0.538 1.000 1.000 565 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2) 2661393 38 29 37 24 20 7 2 5 4 0 0.593 1.000 1.000 566 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2) 2661393 38 29 37 24 20 7 2 5 4 0 0.593 1.000 1.000 567 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(6), ADORA2A(2), ADORA2B(1), ADORA3(12), LTB4R(1), P2RY1(4), P2RY2(8), P2RY6(1) 1995771 35 29 35 28 22 5 0 5 3 0 0.329 1.000 1.000 568 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(6), JAK2(9), JAK3(6), MAPK1(4), MAPK3(1), STAT3(10), TYK2(7) 3894052 43 29 43 31 20 5 3 8 7 0 0.929 1.000 1.000 569 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3D(5), CD3E(2), CD3G(1), IFNG(2), IL2(4), IL2RA(4), IL4(1), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(7), TGFBR3(6), TOB1(2), TOB2(2) 3525657 42 29 42 25 33 2 0 1 6 0 0.563 1.000 1.000 570 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(17), EIF2AK4(13), EIF2B5(1), EIF2S1(1), EIF5(1), GSK3B(2), PPP1CA(1) 3901306 36 28 32 15 16 1 1 12 6 0 0.760 1.000 1.000 571 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(12), ENO1(4), GPI(3), HK1(3), PFKL(4), PGK1(4), PKLR(11) 3073161 41 28 38 17 28 4 1 4 4 0 0.0350 1.000 1.000 572 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), MIOX(3), UGDH(1) 2834324 36 28 34 26 19 7 4 3 3 0 0.784 1.000 1.000 573 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(2), CTSD(3), ESR1(5), GREB1(18), HSPB1(2), HSPB2(1), MTA1(2), MTA3(2), PDZK1(3), TUBA8(3) 3569272 41 28 40 26 30 2 3 4 2 0 0.549 1.000 1.000 574 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(8), CDC25B(4), CDC25C(4), CSK(1), GRB2(2), PRKCA(10), PTPRA(7), SRC(1) 3114858 37 28 36 23 24 6 1 4 2 0 0.705 1.000 1.000 575 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD4(6), CD80(4), HLA-DRA(11), HLA-DRB1(3), IL10(3), IL2(4), IL4(1) 1320155 33 26 33 20 21 1 1 6 4 0 0.435 1.000 1.000 576 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(6), CLOCK(4), CRY1(7), CRY2(3), CSNK1E(4), PER1(8) 2828041 32 26 31 15 19 3 1 3 6 0 0.616 1.000 1.000 577 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(5), ACAA2(1), ACAT2(1), ECHS1(2), EHHADH(6), HADHA(8), HADHB(4), SDS(2) 2803354 29 26 28 14 18 3 1 4 3 0 0.538 1.000 1.000 578 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 12 A4GALT(5), FUT1(3), FUT2(3), GBGT1(2), GLA(1), HEXA(5), HEXB(4), NAGA(3), ST3GAL1(6), ST3GAL2(1), ST3GAL4(1), ST8SIA1(1) 3156897 35 26 34 24 22 4 0 5 4 0 0.684 1.000 1.000 579 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(8), PLCG1(9), PRKCA(10), PTK2B(10) 2265197 37 26 36 26 28 3 1 2 3 0 0.564 1.000 1.000 580 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(6), ADSS(2), IMPDH1(2), MTHFD2(2), POLD1(6), POLG(8), PRPS2(3), RRM1(3) 4159305 32 26 32 25 17 3 1 5 6 0 0.957 1.000 1.000 581 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(5), PSMA2(1), PSMA4(1), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC3(4), PSMD14(1), RPN2(2), UBE3A(6) 4355454 34 26 34 17 18 4 1 8 3 0 0.715 1.000 1.000 582 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(3), BIRC3(7), CASP8(8), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF2(2) 2744700 28 26 28 12 19 1 2 3 3 0 0.340 1.000 1.000 583 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 FOS(2), JUN(1), KEAP1(2), MAFG(1), MAPK1(4), MAPK14(5), MAPK8(1), NFE2L2(4), PRKCA(10) 2962889 30 25 29 14 19 2 0 4 5 0 0.469 1.000 1.000 584 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(3), GBA(3), GBA3(14), GGT1(6), SHMT1(1), SHMT2(2) 1794474 29 25 27 16 22 1 0 3 3 0 0.332 1.000 1.000 585 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(5), B3GALT1(11), B3GALT2(1), B3GALT5(1), B3GNT5(1), FUT1(3), FUT2(3), FUT3(4), ST3GAL3(1), ST3GAL4(1) 2400983 31 25 31 25 23 3 0 3 2 0 0.824 1.000 1.000 586 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(22), RANGAP1(3) 2856977 26 24 26 11 17 2 1 3 3 0 0.651 1.000 1.000 587 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(2), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT5(2), FUT8(8), ST3GAL1(6), ST3GAL2(1), ST3GAL3(1), ST3GAL4(1) 2630152 27 23 27 17 14 6 3 2 2 0 0.722 1.000 1.000 588 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(2), CDC25A(8), CDC25B(4), CDC25C(4), MNAT1(2), SHH(4), XPO1(2) 2926615 26 23 26 11 15 3 2 5 1 0 0.522 1.000 1.000 589 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 11 ALAD(5), ALAS1(1), ALAS2(5), CPO(2), FECH(3), GATA1(2), HBB(6), HMBS(1), UROS(1) 2557315 26 22 25 18 20 2 0 1 3 0 0.701 1.000 1.000 590 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(14), GGT1(6), SHMT1(1), SHMT2(2) 1359033 23 22 21 15 17 1 0 3 2 0 0.473 1.000 1.000 591 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(1), BDH1(5), HMGCL(4), HMGCS1(2), HMGCS2(17), OXCT1(4), OXCT2(3) 2393850 36 22 35 20 24 5 0 5 2 0 0.677 1.000 1.000 592 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 CAMP(1), CREB3(1), CREB5(9), MAPK1(4), RAF1(8), SNX13(1), SRC(1), TERF2IP(1) 3245548 26 22 26 27 15 3 1 4 3 0 0.997 1.000 1.000 593 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(5), FUT1(3), FUT2(3), FUT3(4), FUT5(6), FUT6(4), ST3GAL3(1) 1671750 26 21 26 18 15 3 1 2 5 0 0.478 1.000 1.000 594 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(2), HBXIP(1), HRAS(3), PTK2B(10), SHC1(1), SOS1(8), SRC(1) 2947939 26 21 26 22 18 2 0 4 2 0 0.983 1.000 1.000 595 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(2), DNAJC3(2), EIF2S1(1), MAP3K14(3), NFKB1(7), NFKBIA(2), RELA(4) 2969544 21 21 21 12 11 4 1 4 1 0 0.761 1.000 1.000 596 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 10 ACLY(9), ACO1(5), ACO2(4), ACSS1(1), ACSS2(4), FH(3), IDH2(2), MDH1(1), MDH2(4) 4195866 33 20 31 22 21 0 2 6 4 0 0.725 1.000 1.000 597 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(4), CS(2), FH(3), IDH2(2), MDH1(1), OGDH(11), SDHA(1) 3176777 24 20 23 17 15 0 2 3 4 0 0.860 1.000 1.000 598 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(1), CSF1(10), IL6(2), LDLR(14), LPL(3) 1796343 30 20 30 15 21 3 2 3 1 0 0.321 1.000 1.000 599 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), CSF1(10), IL1B(6), MST1(1), MST1R(7), TNF(1) 2192503 26 20 25 21 20 2 1 0 3 0 0.845 1.000 1.000 600 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), CD4(6), HLA-DRA(11), HLA-DRB1(3) 788509 21 19 21 14 16 1 0 3 1 0 0.536 1.000 1.000 601 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(8), EPHX2(4), HSD3B7(3), RDH11(2), RDH12(2), RDH13(3) 1616002 22 19 22 17 15 1 2 1 3 0 0.763 1.000 1.000 602 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(21), PNPO(1), PSAT1(2) 1631742 24 19 23 18 20 1 1 2 0 0 0.856 1.000 1.000 603 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(5), APOBEC1(3), APOBEC2(3), APOBEC3A(2), APOBEC3B(2), APOBEC3C(2), APOBEC3F(4), APOBEC3G(2) 2478826 23 19 23 26 17 2 3 1 0 0 0.993 1.000 1.000 604 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(4), IFNGR2(4), JAK1(6), JAK2(9), STAT1(4) 2736082 29 19 27 10 11 1 1 7 9 0 0.687 1.000 1.000 605 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL1(6), ST3GAL2(1), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(2), ST6GALNAC4(1), ST8SIA1(1) 1902275 16 16 16 11 11 2 1 2 0 0 0.650 1.000 1.000 606 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(7), CD28(1), CD3D(5), CD3E(2), CD3G(1), CD4(6) 1074220 22 16 22 22 15 3 0 3 1 0 0.918 1.000 1.000 607 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(1), COQ3(2), COQ5(2), COQ6(1), COQ7(2), NDUFA12(1), NDUFA13(6) 1333886 15 15 14 11 12 1 2 0 0 0 0.873 1.000 1.000 608 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 8 ACO1(5), ACO2(4), FH(3), IDH2(2), MDH1(1), MDH2(4), SDHB(1) 2721683 20 15 18 13 13 0 2 2 3 0 0.709 1.000 1.000 609 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(5), BMPR1A(2), BMPR1B(3), BMPR2(5) 2106226 15 15 15 10 7 3 0 3 2 0 0.837 1.000 1.000 610 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(4), HGD(12) 754252 16 14 16 16 12 2 2 0 0 0 0.938 1.000 1.000 611 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 6 ABO(5), B3GNT1(2), FUT1(3), FUT2(3), ST8SIA1(1) 1777543 14 13 14 12 11 1 1 1 0 0 0.770 1.000 1.000 612 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(1), DLL1(2), FURIN(5), NOTCH1(5), PSEN1(1) 3078315 14 13 14 17 7 3 1 3 0 0 0.982 1.000 1.000 613 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(17) 612499 19 12 18 11 14 2 1 2 0 0 0.580 1.000 1.000 614 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(6), ARG1(1), GLS(2), GLUD1(2), OAT(3), PRODH(1) 1823373 15 11 15 13 5 5 2 2 1 0 0.950 1.000 1.000 615 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(2), TGDS(1), UGDH(1), UGP2(1), UXS1(4) 1652848 9 9 9 10 4 0 1 0 4 0 0.987 1.000 1.000 616 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(4) 712936 4 4 4 5 3 0 0 1 0 0 0.943 1.000 1.000