E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.094 0.188 -9999.0 0.0 -0.383 71.0 71.0 KLHL20 -0.018 0.082 -9999.0 0.0 -0.205 12.0 12.0 CYFIP2 -0.009 0.093 -9999.0 0.0 -0.377 14.0 14.0 Rac1/GDP -0.035 0.118 -9999.0 0.0 -0.214 67.0 67.0 ENAH -0.098 0.19 -9999.0 0.0 -0.388 71.0 71.0 AP1M1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.012 0.017 -9999.0 0.0 -0.259 1.0 1.0 RAP1A 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.043 0.062 -9999.0 0.0 -0.267 1.0 1.0 ABI1/Sra1/Nap1 -0.033 0.046 -9999.0 0.0 -0.148 16.0 16.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.057 0.122 -9999.0 0.0 -0.218 80.0 80.0 RAPGEF1 -0.073 0.167 -9999.0 0.0 -0.33 71.0 71.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.101 0.193 -9999.0 0.0 -0.398 71.0 71.0 CRK -0.084 0.179 -9999.0 0.0 -0.36 71.0 71.0 E-cadherin/gamma catenin/alpha catenin -0.061 0.122 -9999.0 0.0 -0.237 71.0 71.0 alphaE/beta7 Integrin 0.001 0.074 -9999.0 0.0 -0.274 16.0 16.0 IQGAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.023 0.025 -9999.0 0.0 -0.206 2.0 2.0 DLG1 -0.093 0.188 -9999.0 0.0 -0.383 71.0 71.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.032 0.046 -9999.0 0.0 -0.185 2.0 2.0 MLLT4 0.009 0.042 -9999.0 0.0 -0.359 3.0 3.0 ARF6/GTP/NME1/Tiam1 0.011 0.057 -9999.0 0.0 -0.206 15.0 15.0 PI3K -0.04 0.058 -9999.0 0.0 -0.237 2.0 2.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.083 0.143 -9999.0 0.0 -0.267 87.0 87.0 TIAM1 -0.014 0.103 -9999.0 0.0 -0.4 16.0 16.0 E-cadherin(dimer)/Ca2+ -0.04 0.1 -9999.0 0.0 -0.188 71.0 71.0 AKT1 -0.023 0.034 -9999.0 0.0 -0.136 2.0 2.0 PIK3R1 0.01 0.038 -9999.0 0.0 -0.41 2.0 2.0 CDH1 -0.126 0.193 -9999.0 0.0 -0.386 84.0 84.0 RhoA/GDP -0.035 0.118 -9999.0 0.0 -0.214 67.0 67.0 actin cytoskeleton organization -0.012 0.062 -9999.0 0.0 -0.15 12.0 12.0 CDC42/GDP -0.035 0.118 -9999.0 0.0 -0.214 67.0 67.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.052 0.105 -9999.0 0.0 -0.209 71.0 71.0 ITGB7 -0.014 0.103 -9999.0 0.0 -0.4 16.0 16.0 RAC1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.042 0.107 -9999.0 0.0 -0.201 71.0 71.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.047 0.099 -9999.0 0.0 -0.193 71.0 71.0 mol:GDP -0.048 0.132 -9999.0 0.0 -0.248 71.0 71.0 CDC42/GTP/IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.006 0.052 -9999.0 0.0 -0.309 6.0 6.0 p120 catenin/RhoA/GDP -0.036 0.119 -9999.0 0.0 -0.217 67.0 67.0 RAC1/GTP/IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.006 0.047 -9999.0 0.0 -0.128 11.0 11.0 NME1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.097 0.189 -9999.0 0.0 -0.385 71.0 71.0 regulation of cell-cell adhesion -0.038 0.055 -9999.0 0.0 -0.235 1.0 1.0 WASF2 -0.017 0.025 -9999.0 0.0 -0.102 3.0 3.0 Rap1/GTP -0.022 0.089 -9999.0 0.0 -0.304 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.05 0.12 -9999.0 0.0 -0.206 80.0 80.0 CCND1 -0.008 0.056 -9999.0 0.0 -0.156 11.0 11.0 VAV2 -0.093 0.203 -9999.0 0.0 -0.382 75.0 75.0 RAP1/GDP -0.027 0.099 -9999.0 0.0 -0.269 2.0 2.0 adherens junction assembly -0.094 0.184 -9999.0 0.0 -0.374 71.0 71.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.044 0.114 -9999.0 0.0 -0.347 10.0 10.0 E-cadherin/beta catenin -0.084 0.142 -9999.0 0.0 -0.301 71.0 71.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.094 0.189 -9999.0 0.0 -0.385 71.0 71.0 PIK3CA 0.01 0.038 -9999.0 0.0 -0.41 2.0 2.0 Rac1/GTP -0.068 0.099 -9999.0 0.0 -0.314 14.0 14.0 E-cadherin/beta catenin/alpha catenin -0.056 0.117 -9999.0 0.0 -0.229 71.0 71.0 ITGAE 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.103 0.197 -9999.0 0.0 -0.407 71.0 71.0