Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.036 0.179 -9999.0 0.0 -0.528 22.0 22.0 IHH -0.003 0.057 -9999.0 0.0 -0.245 7.0 7.0 SHH Np/Cholesterol/GAS1 0.002 0.051 -9999.0 0.0 -0.163 20.0 20.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.002 0.051 0.162 20.0 -9999.0 0.0 20.0 SMO/beta Arrestin2 -0.032 0.144 -9999.0 0.0 -0.382 22.0 22.0 SMO -0.04 0.15 -9999.0 0.0 -0.379 26.0 26.0 AKT1 -0.004 0.078 -9999.0 0.0 -0.244 9.0 9.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.012 0.088 -9999.0 0.0 -0.306 19.0 19.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.04 0.148 -9999.0 0.0 -0.364 28.0 28.0 STIL -0.009 0.097 -9999.0 0.0 -0.271 19.0 19.0 DHH N/PTCH2 -0.023 0.093 -9999.0 0.0 -0.208 45.0 45.0 DHH N/PTCH1 -0.031 0.131 -9999.0 0.0 -0.321 27.0 27.0 PIK3CA 0.01 0.038 -9999.0 0.0 -0.41 2.0 2.0 DHH -0.035 0.116 -9999.0 0.0 -0.299 37.0 37.0 PTHLH -0.05 0.237 -9999.0 0.0 -0.728 22.0 22.0 determination of left/right symmetry -0.04 0.148 -9999.0 0.0 -0.364 28.0 28.0 PIK3R1 0.01 0.038 -9999.0 0.0 -0.41 2.0 2.0 skeletal system development -0.049 0.234 -9999.0 0.0 -0.719 22.0 22.0 IHH N/Hhip -0.006 0.066 -9999.0 0.0 -0.216 18.0 18.0 DHH N/Hhip -0.029 0.093 -9999.0 0.0 -0.201 51.0 51.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.04 0.148 -9999.0 0.0 -0.364 28.0 28.0 pancreas development -0.011 0.071 -9999.0 0.0 -0.258 18.0 18.0 HHAT 0.005 0.06 -9999.0 0.0 -0.41 5.0 5.0 PI3K 0.015 0.044 -9999.0 0.0 -0.363 3.0 3.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.004 0.063 -9999.0 0.0 -0.385 6.0 6.0 somite specification -0.04 0.148 -9999.0 0.0 -0.364 28.0 28.0 SHH Np/Cholesterol/PTCH1 -0.013 0.102 -9999.0 0.0 -0.281 21.0 21.0 SHH Np/Cholesterol/PTCH2 0.0 0.054 -9999.0 0.0 -0.158 23.0 23.0 SHH Np/Cholesterol/Megalin -0.094 0.106 -9999.0 0.0 -0.17 143.0 143.0 SHH -0.001 0.054 -9999.0 0.0 -0.209 14.0 14.0 catabolic process -0.015 0.122 -9999.0 0.0 -0.359 20.0 20.0 SMO/Vitamin D3 -0.024 0.121 -9999.0 0.0 -0.326 24.0 24.0 SHH Np/Cholesterol/Hhip -0.005 0.057 -9999.0 0.0 -0.176 17.0 17.0 LRP2 -0.182 0.176 -9999.0 0.0 -0.325 139.0 139.0 receptor-mediated endocytosis -0.087 0.146 -9999.0 0.0 -0.342 42.0 42.0 SHH Np/Cholesterol/BOC -0.006 0.059 -9999.0 0.0 -0.166 22.0 22.0 SHH Np/Cholesterol/CDO 0.005 0.051 -9999.0 0.0 -0.24 7.0 7.0 mesenchymal cell differentiation 0.005 0.057 0.175 17.0 -9999.0 0.0 17.0 mol:Vitamin D3 -0.011 0.103 -9999.0 0.0 -0.282 21.0 21.0 IHH N/PTCH2 0.002 0.065 -9999.0 0.0 -0.263 11.0 11.0 CDON 0.008 0.047 -9999.0 0.0 -0.41 3.0 3.0 IHH N/PTCH1 -0.013 0.123 -9999.0 0.0 -0.361 20.0 20.0 Megalin/LRPAP1 -0.116 0.124 -9999.0 0.0 -0.216 139.0 139.0 PTCH2 -0.0 0.068 -9999.0 0.0 -0.319 10.0 10.0 SHH Np/Cholesterol 0.001 0.04 -9999.0 0.0 -0.155 14.0 14.0 PTCH1 -0.015 0.122 -9999.0 0.0 -0.36 20.0 20.0 HHIP -0.011 0.071 -9999.0 0.0 -0.259 18.0 18.0