Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.043 0.099 -9999.0 0.0 -0.195 71.0 71.0 epithelial cell differentiation -0.041 0.098 -9999.0 0.0 -0.186 71.0 71.0 CYFIP2 -0.009 0.093 -9999.0 0.0 -0.377 14.0 14.0 ENAH -0.015 0.078 -9999.0 0.0 -0.223 7.0 7.0 EGFR -0.017 0.095 -9999.0 0.0 -0.296 24.0 24.0 EPHA2 -0.002 0.077 -9999.0 0.0 -0.364 10.0 10.0 MYO6 -0.044 0.097 -9999.0 0.0 -0.177 78.0 78.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.014 0.056 -9999.0 0.0 -0.229 11.0 11.0 AQP5 -0.043 0.101 -9999.0 0.0 -0.493 4.0 4.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.037 0.091 -9999.0 0.0 -0.171 71.0 71.0 regulation of calcium-dependent cell-cell adhesion -0.048 0.101 -9999.0 0.0 -0.187 75.0 75.0 EGF -0.091 0.173 -9999.0 0.0 -0.366 66.0 66.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.055 0.143 -9999.0 0.0 -0.479 17.0 17.0 cortical microtubule organization -0.041 0.098 -9999.0 0.0 -0.186 71.0 71.0 GO:0000145 -0.036 0.086 -9999.0 0.0 -0.163 71.0 71.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.04 0.1 -9999.0 0.0 -0.188 71.0 71.0 MLLT4 0.009 0.042 -9999.0 0.0 -0.359 3.0 3.0 ARF6/GDP -0.049 0.067 -9999.0 0.0 -0.254 4.0 4.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.026 0.042 -9999.0 0.0 -0.201 7.0 7.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.03 0.088 -9999.0 0.0 -0.202 2.0 2.0 PVRL2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.038 0.094 -9999.0 0.0 -0.176 71.0 71.0 ARF6/GTP 0.03 0.039 -9999.0 0.0 -0.181 7.0 7.0 CDH1 -0.126 0.193 -9999.0 0.0 -0.386 84.0 84.0 EGFR/EGFR/EGF/EGF -0.106 0.122 -9999.0 0.0 -0.34 37.0 37.0 RhoA/GDP -0.036 0.092 -9999.0 0.0 -0.172 71.0 71.0 actin cytoskeleton organization -0.039 0.095 -9999.0 0.0 -0.171 72.0 72.0 IGF-1R heterotetramer 0.009 0.042 -9999.0 0.0 -0.359 3.0 3.0 GIT1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.009 0.042 -9999.0 0.0 -0.359 3.0 3.0 IGF1 -0.024 0.116 -9999.0 0.0 -0.377 23.0 23.0 DIAPH1 -0.02 0.124 -9999.0 0.0 -0.583 11.0 11.0 Wnt receptor signaling pathway 0.041 0.098 0.186 71.0 -9999.0 0.0 71.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.049 0.068 -9999.0 0.0 -0.255 4.0 4.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.04 0.096 -9999.0 0.0 -0.175 72.0 72.0 EFNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.035 0.089 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.059 0.08 -9999.0 0.0 -0.293 4.0 4.0 SEC6/SEC8 -0.048 0.066 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.048 0.103 -9999.0 0.0 -0.189 75.0 75.0 HGF/MET -0.089 0.108 -9999.0 0.0 -0.307 30.0 30.0 HGF -0.025 0.11 -9999.0 0.0 -0.326 27.0 27.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.043 0.1 -9999.0 0.0 -0.196 71.0 71.0 actin cable formation -0.004 0.078 -9999.0 0.0 -0.232 4.0 4.0 KIAA1543 -0.071 0.114 -9999.0 0.0 -0.256 36.0 36.0 KIFC3 -0.038 0.092 -9999.0 0.0 -0.173 72.0 72.0 NCK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.017 -9999.0 0.0 -0.259 1.0 1.0 ACTN1 -0.041 0.093 -9999.0 0.0 -0.173 75.0 75.0 NCK1/GIT1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.041 0.098 -9999.0 0.0 -0.186 71.0 71.0 EXOC4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.037 0.092 -9999.0 0.0 -0.173 71.0 71.0 PIP5K1C -0.037 0.092 -9999.0 0.0 -0.173 71.0 71.0 LIMA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.019 0.081 -9999.0 0.0 -0.224 4.0 4.0 adherens junction assembly -0.055 0.112 -9999.0 0.0 -0.287 22.0 22.0 IGF-1R heterotetramer/IGF1 -0.069 0.091 -9999.0 0.0 -0.334 9.0 9.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.017 0.03 -9999.0 0.0 -0.281 2.0 2.0 MET -0.041 0.135 -9999.0 0.0 -0.362 35.0 35.0 PLEKHA7 -0.049 0.104 -9999.0 0.0 -0.188 78.0 78.0 mol:GTP 0.025 0.042 -9999.0 0.0 -0.2 7.0 7.0 establishment of epithelial cell apical/basal polarity -0.017 0.083 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.043 0.099 -9999.0 0.0 -0.195 71.0 71.0 regulation of cell-cell adhesion -0.039 0.095 -9999.0 0.0 -0.171 72.0 72.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.043 0.1 -9999.0 0.0 -0.196 71.0 71.0