E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.099 0.186 0.228 1.0 -0.368 75.0 76.0 KLHL20 -0.03 0.094 0.19 4.0 -0.211 23.0 27.0 CYFIP2 0.015 0.066 0.122 3.0 -0.316 9.0 12.0 Rac1/GDP -0.047 0.118 0.219 2.0 -0.228 56.0 58.0 ENAH -0.095 0.182 0.223 1.0 -0.375 67.0 68.0 AP1M1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.019 0.083 0.138 1.0 -0.154 49.0 50.0 ABI1/Sra1/Nap1 -0.04 0.054 -9999.0 0.0 -0.143 29.0 29.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.007 0.114 -9999.0 0.0 -0.173 74.0 74.0 RAPGEF1 -0.082 0.167 0.22 3.0 -0.335 66.0 69.0 CTNND1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.096 0.195 -9999.0 0.0 -0.374 78.0 78.0 CRK -0.088 0.176 0.215 1.0 -0.351 70.0 71.0 E-cadherin/gamma catenin/alpha catenin -0.012 0.112 -9999.0 0.0 -0.189 66.0 66.0 alphaE/beta7 Integrin 0.027 0.057 -9999.0 0.0 -0.214 12.0 12.0 IQGAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.044 0.028 -9999.0 0.0 -0.154 2.0 2.0 DLG1 -0.098 0.186 -9999.0 0.0 -0.368 76.0 76.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.04 0.047 -9999.0 0.0 -0.121 53.0 53.0 MLLT4 0.022 0.032 -9999.0 0.0 -0.316 2.0 2.0 ARF6/GTP/NME1/Tiam1 0.041 0.049 -9999.0 0.0 -0.164 12.0 12.0 PI3K -0.035 0.069 -9999.0 0.0 -0.152 50.0 50.0 ARF6 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.03 0.122 -9999.0 0.0 -0.224 66.0 66.0 TIAM1 0.011 0.075 -9999.0 0.0 -0.316 12.0 12.0 E-cadherin(dimer)/Ca2+ 0.002 0.101 -9999.0 0.0 -0.158 66.0 66.0 AKT1 -0.025 0.048 0.123 2.0 -0.129 2.0 4.0 PIK3R1 0.025 0.032 -9999.0 0.0 -0.316 2.0 2.0 CDH1 -0.062 0.157 0.122 12.0 -0.316 66.0 78.0 RhoA/GDP -0.044 0.128 0.254 4.0 -0.227 61.0 65.0 actin cytoskeleton organization -0.021 0.071 0.149 5.0 -0.155 23.0 28.0 CDC42/GDP -0.046 0.127 0.254 4.0 -0.227 61.0 65.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.038 0.096 -9999.0 0.0 -0.19 66.0 66.0 ITGB7 0.011 0.075 -9999.0 0.0 -0.316 12.0 12.0 RAC1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.003 0.109 -9999.0 0.0 -0.169 66.0 66.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.008 0.092 -9999.0 0.0 -0.154 66.0 66.0 mol:GDP -0.062 0.135 0.258 4.0 -0.257 61.0 65.0 CDC42/GTP/IQGAP1 0.036 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.027 0.034 0.122 4.0 -0.316 2.0 6.0 p120 catenin/RhoA/GDP -0.04 0.131 0.23 4.0 -0.233 58.0 62.0 RAC1/GTP/IQGAP1 0.033 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.042 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.011 0.055 0.129 8.0 -0.106 23.0 31.0 NME1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.101 0.187 -9999.0 0.0 -0.368 77.0 77.0 regulation of cell-cell adhesion -0.025 0.066 -9999.0 0.0 -0.138 52.0 52.0 WASF2 -0.014 0.04 0.093 3.0 -0.084 21.0 24.0 Rap1/GTP -0.019 0.095 0.188 11.0 -0.167 50.0 61.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.0 0.118 -9999.0 0.0 -0.169 73.0 73.0 CCND1 -0.014 0.065 0.154 7.0 -0.129 23.0 30.0 VAV2 -0.122 0.249 0.354 1.0 -0.439 78.0 79.0 RAP1/GDP -0.025 0.108 0.264 3.0 -0.185 54.0 57.0 adherens junction assembly -0.1 0.182 -9999.0 0.0 -0.357 78.0 78.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.01 0.108 0.208 3.0 -0.166 72.0 75.0 E-cadherin/beta catenin -0.065 0.128 -9999.0 0.0 -0.275 65.0 65.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.097 0.183 0.223 1.0 -0.367 72.0 73.0 PIK3CA 0.025 0.031 -9999.0 0.0 -0.316 2.0 2.0 Rac1/GTP -0.075 0.125 -9999.0 0.0 -0.334 26.0 26.0 E-cadherin/beta catenin/alpha catenin -0.011 0.109 -9999.0 0.0 -0.185 66.0 66.0 ITGAE 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.099 0.198 -9999.0 0.0 -0.382 78.0 78.0