Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.017 0.119 -9999.0 0.0 -0.442 13.0 13.0 IHH 0.032 0.052 0.144 6.0 -0.133 17.0 23.0 SHH Np/Cholesterol/GAS1 0.015 0.03 -9999.0 0.0 -0.168 5.0 5.0 LRPAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.015 0.03 0.167 5.0 -9999.0 0.0 5.0 SMO/beta Arrestin2 0.011 0.132 -9999.0 0.0 -0.365 13.0 13.0 SMO -0.013 0.122 -9999.0 0.0 -0.383 14.0 14.0 AKT1 -0.0 0.101 -9999.0 0.0 -0.365 10.0 10.0 ARRB2 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.024 0.059 0.122 13.0 -0.316 6.0 19.0 ADRBK1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.012 0.12 -9999.0 0.0 -0.378 14.0 14.0 STIL 0.022 0.088 0.186 31.0 -0.229 13.0 44.0 DHH N/PTCH2 0.035 0.068 0.179 2.0 -0.219 14.0 16.0 DHH N/PTCH1 0.024 0.109 -9999.0 0.0 -0.336 16.0 16.0 PIK3CA 0.025 0.031 -9999.0 0.0 -0.316 2.0 2.0 DHH 0.024 0.077 -9999.0 0.0 -0.316 10.0 10.0 PTHLH -0.002 0.178 -9999.0 0.0 -0.629 16.0 16.0 determination of left/right symmetry -0.012 0.12 -9999.0 0.0 -0.378 14.0 14.0 PIK3R1 0.025 0.032 -9999.0 0.0 -0.316 2.0 2.0 skeletal system development -0.002 0.176 -9999.0 0.0 -0.623 16.0 16.0 IHH N/Hhip 0.045 0.043 0.188 3.0 -9999.0 0.0 3.0 DHH N/Hhip 0.04 0.062 0.179 4.0 -0.22 10.0 14.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.012 0.12 -9999.0 0.0 -0.378 14.0 14.0 pancreas development 0.032 0.026 0.122 18.0 -9999.0 0.0 18.0 HHAT 0.019 0.049 -9999.0 0.0 -0.316 5.0 5.0 PI3K 0.036 0.038 -9999.0 0.0 -0.279 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.023 0.039 0.122 1.0 -0.316 3.0 4.0 somite specification -0.012 0.12 -9999.0 0.0 -0.378 14.0 14.0 SHH Np/Cholesterol/PTCH1 0.01 0.068 -9999.0 0.0 -0.237 13.0 13.0 SHH Np/Cholesterol/PTCH2 0.018 0.035 0.157 2.0 -0.169 6.0 8.0 SHH Np/Cholesterol/Megalin 0.002 0.102 0.193 12.0 -0.171 52.0 64.0 SHH -0.008 0.028 -9999.0 0.0 -0.223 3.0 3.0 catabolic process 0.011 0.102 -9999.0 0.0 -0.356 16.0 16.0 SMO/Vitamin D3 0.008 0.1 0.242 5.0 -0.283 15.0 20.0 SHH Np/Cholesterol/Hhip 0.016 0.039 0.157 6.0 -0.167 3.0 9.0 LRP2 -0.029 0.172 -9999.0 0.0 -0.316 61.0 61.0 receptor-mediated endocytosis -0.026 0.122 0.212 1.0 -0.342 17.0 18.0 SHH Np/Cholesterol/BOC 0.018 0.039 0.201 1.0 -0.169 7.0 8.0 SHH Np/Cholesterol/CDO 0.014 0.034 -9999.0 0.0 -0.197 5.0 5.0 mesenchymal cell differentiation -0.016 0.038 0.166 3.0 -0.155 6.0 9.0 mol:Vitamin D3 0.037 0.097 0.214 32.0 -0.238 13.0 45.0 IHH N/PTCH2 0.038 0.052 0.201 1.0 -0.237 4.0 5.0 CDON 0.021 0.039 -9999.0 0.0 -0.316 3.0 3.0 IHH N/PTCH1 0.022 0.108 0.226 1.0 -0.347 17.0 18.0 Megalin/LRPAP1 -0.005 0.129 -9999.0 0.0 -0.219 61.0 61.0 PTCH2 0.025 0.047 0.122 6.0 -0.316 4.0 10.0 SHH Np/Cholesterol 0.01 0.021 -9999.0 0.0 -0.165 3.0 3.0 PTCH1 0.011 0.102 -9999.0 0.0 -0.357 16.0 16.0 HHIP 0.032 0.026 0.122 18.0 -9999.0 0.0 18.0