Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.033 0.093 -9999.0 0.0 -0.181 67.0 67.0 epithelial cell differentiation -0.001 0.098 -9999.0 0.0 -0.157 66.0 66.0 CYFIP2 0.015 0.066 0.122 3.0 -0.316 9.0 12.0 ENAH -0.046 0.065 0.267 1.0 -0.224 4.0 5.0 EGFR 0.025 0.056 -9999.0 0.0 -0.316 5.0 5.0 EPHA2 0.019 0.059 -9999.0 0.0 -0.316 7.0 7.0 MYO6 -0.047 0.077 0.21 5.0 -0.288 1.0 6.0 CTNNB1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.043 0.049 -9999.0 0.0 -0.18 9.0 9.0 AQP5 -0.026 0.093 0.427 1.0 -0.424 5.0 6.0 CTNND1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.044 0.074 0.208 5.0 -9999.0 0.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.043 0.079 0.221 5.0 -0.284 2.0 7.0 EGF -0.029 0.14 -9999.0 0.0 -0.316 45.0 45.0 NCKAP1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.05 0.118 0.384 1.0 -0.346 22.0 23.0 cortical microtubule organization -0.001 0.098 -9999.0 0.0 -0.157 66.0 66.0 GO:0000145 -0.044 0.069 0.197 5.0 -0.145 63.0 68.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.002 0.101 -9999.0 0.0 -0.158 66.0 66.0 MLLT4 0.022 0.032 -9999.0 0.0 -0.316 2.0 2.0 ARF6/GDP -0.054 0.058 -9999.0 0.0 -0.15 61.0 61.0 ARF6 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.056 0.048 -9999.0 0.0 -0.167 7.0 7.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.033 0.068 0.21 4.0 -9999.0 0.0 4.0 PVRL2 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.042 0.072 0.216 4.0 -9999.0 0.0 4.0 ARF6/GTP 0.061 0.049 -9999.0 0.0 -0.157 7.0 7.0 CDH1 -0.062 0.157 0.122 12.0 -0.316 66.0 78.0 EGFR/EGFR/EGF/EGF -0.038 0.113 -9999.0 0.0 -0.173 90.0 90.0 RhoA/GDP 0.0 0.096 -9999.0 0.0 -0.152 66.0 66.0 actin cytoskeleton organization -0.048 0.074 0.194 5.0 -0.159 57.0 62.0 IGF-1R heterotetramer 0.025 0.032 -9999.0 0.0 -0.315 2.0 2.0 GIT1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.025 0.032 -9999.0 0.0 -0.316 2.0 2.0 IGF1 0.007 0.087 0.122 5.0 -0.316 16.0 21.0 DIAPH1 -0.03 0.212 -9999.0 0.0 -0.531 34.0 34.0 Wnt receptor signaling pathway 0.001 0.098 0.157 66.0 -9999.0 0.0 66.0 RHOA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.055 0.058 -9999.0 0.0 -0.151 58.0 58.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.049 0.076 0.196 5.0 -0.162 57.0 62.0 EFNA1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.049 0.072 0.202 5.0 -9999.0 0.0 5.0 Ephrin A1/EPHA2 -0.009 0.09 -9999.0 0.0 -0.153 65.0 65.0 SEC6/SEC8 -0.048 0.059 -9999.0 0.0 -0.15 52.0 52.0 MGAT3 -0.043 0.08 0.222 5.0 -0.288 2.0 7.0 HGF/MET -0.024 0.106 -9999.0 0.0 -0.169 77.0 77.0 HGF 0.015 0.076 0.122 13.0 -0.316 11.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.033 0.093 -9999.0 0.0 -0.183 67.0 67.0 actin cable formation -0.017 0.106 0.278 12.0 -0.266 5.0 17.0 KIAA1543 -0.047 0.073 0.198 5.0 -0.151 66.0 71.0 KIFC3 -0.048 0.072 0.235 3.0 -9999.0 0.0 3.0 NCK1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.047 0.075 0.21 5.0 -9999.0 0.0 5.0 NCK1/GIT1 0.04 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.001 0.098 -9999.0 0.0 -0.157 66.0 66.0 EXOC4 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.045 0.075 0.21 5.0 -0.154 64.0 69.0 PIP5K1C -0.045 0.075 0.21 5.0 -9999.0 0.0 5.0 LIMA1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.034 0.095 0.445 3.0 -0.226 1.0 4.0 adherens junction assembly -0.045 0.087 0.32 2.0 -0.306 7.0 9.0 IGF-1R heterotetramer/IGF1 -0.018 0.101 -9999.0 0.0 -0.159 77.0 77.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.034 0.028 -9999.0 0.0 -0.219 2.0 2.0 MET -0.001 0.099 0.122 8.0 -0.316 21.0 29.0 PLEKHA7 -0.047 0.079 0.21 5.0 -0.158 63.0 68.0 mol:GTP 0.054 0.047 -9999.0 0.0 -0.166 7.0 7.0 establishment of epithelial cell apical/basal polarity -0.018 0.108 0.322 7.0 -9999.0 0.0 7.0 cortical actin cytoskeleton stabilization -0.033 0.093 -9999.0 0.0 -0.181 67.0 67.0 regulation of cell-cell adhesion -0.048 0.074 0.194 5.0 -0.159 57.0 62.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.033 0.093 -9999.0 0.0 -0.183 67.0 67.0