Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	47.0	329.0	7.0	-0.043	-0.0	1000.0	-1000.0	-0.0	-1000.0
E-cadherin signaling events	43.0	216.0	5.0	-0.062	0.028	1000.0	-1000.0	0.02	-1000.0
TCR signaling in naïve CD8+ T cells	37.0	3490.0	93.0	-0.204	0.127	1000.0	-1000.0	-0.027	-1000.0
IL23-mediated signaling events	37.0	2238.0	60.0	-0.29	0.028	1000.0	-1000.0	-0.037	-1000.0
IL4-mediated signaling events	33.0	3036.0	91.0	-0.488	0.374	1000.0	-1000.0	-0.088	-1000.0
E-cadherin signaling in the nascent adherens junction	33.0	2561.0	76.0	-0.122	0.044	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	33.0	2624.0	78.0	-0.194	0.064	1000.0	-1000.0	-0.038	-1000.0
Angiopoietin receptor Tie2-mediated signaling	31.0	2762.0	88.0	-0.207	0.038	1000.0	-1000.0	-0.05	-1000.0
Signaling events regulated by Ret tyrosine kinase	30.0	2498.0	82.0	-0.053	0.033	1000.0	-1000.0	-0.03	-1000.0
Syndecan-1-mediated signaling events	29.0	996.0	34.0	-0.053	0.028	1000.0	-1000.0	-0.014	-1000.0
Endothelins	29.0	2850.0	96.0	-0.112	0.052	1000.0	-1000.0	-0.026	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	29.0	2037.0	68.0	-0.294	0.085	1000.0	-1000.0	-0.052	-1000.0
IL12-mediated signaling events	28.0	2476.0	87.0	-0.271	0.061	1000.0	-1000.0	-0.034	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	27.0	2021.0	74.0	-0.062	0.061	1000.0	-1000.0	-0.039	-1000.0
E-cadherin signaling in keratinocytes	26.0	1159.0	43.0	-0.069	0.031	1000.0	-1000.0	-0.012	-1000.0
BCR signaling pathway	25.0	2526.0	99.0	-0.144	0.035	1000.0	-1000.0	-0.056	-1000.0
LPA receptor mediated events	24.0	2449.0	102.0	-0.078	0.031	1000.0	-1000.0	-0.055	-1000.0
TCGA08_retinoblastoma	23.0	188.0	8.0	-0.008	0.049	1000.0	-1000.0	-0.004	-1000.0
Nectin adhesion pathway	22.0	1401.0	63.0	-0.093	0.044	1000.0	-1000.0	-0.036	-1000.0
Integrins in angiogenesis	22.0	1875.0	84.0	-0.105	0.051	1000.0	-1000.0	-0.016	-1000.0
Wnt signaling	22.0	158.0	7.0	-0.026	0.025	1000.0	-1000.0	-0.001	-1000.0
Osteopontin-mediated events	21.0	832.0	38.0	-0.049	0.031	1000.0	-1000.0	-0.018	-1000.0
Thromboxane A2 receptor signaling	20.0	2131.0	105.0	-0.075	0.034	1000.0	-1000.0	-0.024	-1000.0
p75(NTR)-mediated signaling	20.0	2544.0	125.0	-0.054	0.072	1000.0	-1000.0	-0.035	-1000.0
Glypican 1 network	20.0	986.0	48.0	-0.037	0.042	1000.0	-1000.0	-0.021	-1000.0
Signaling mediated by p38-alpha and p38-beta	20.0	886.0	44.0	-0.061	0.028	1000.0	-1000.0	-0.008	-1000.0
EPHB forward signaling	20.0	1763.0	85.0	-0.051	0.051	1000.0	-1000.0	-0.039	-1000.0
Glypican 2 network	20.0	81.0	4.0	0.009	0.013	1000.0	-1000.0	0.021	-1000.0
IL27-mediated signaling events	20.0	1050.0	51.0	-0.163	0.1	1000.0	-1000.0	-0.024	-1000.0
EGFR-dependent Endothelin signaling events	20.0	428.0	21.0	-0.037	0.041	1000.0	-1000.0	-0.029	-1000.0
S1P4 pathway	20.0	517.0	25.0	-0.032	0.036	1000.0	-1000.0	-0.012	-1000.0
FAS signaling pathway (CD95)	19.0	936.0	47.0	-0.022	0.037	1000.0	-1000.0	-0.034	-1000.0
Caspase cascade in apoptosis	18.0	1355.0	74.0	-0.06	0.038	1000.0	-1000.0	-0.026	-1000.0
JNK signaling in the CD4+ TCR pathway	18.0	316.0	17.0	-0.087	0.038	1000.0	-1000.0	-0.024	-1000.0
Noncanonical Wnt signaling pathway	18.0	484.0	26.0	-0.036	0.027	1000.0	-1000.0	-0.019	-1000.0
Glucocorticoid receptor regulatory network	18.0	2064.0	114.0	-0.233	0.114	1000.0	-1000.0	-0.038	-1000.0
Calcium signaling in the CD4+ TCR pathway	18.0	570.0	31.0	-0.083	0.029	1000.0	-1000.0	-0.028	-1000.0
a4b1 and a4b7 Integrin signaling	17.0	86.0	5.0	0.001	0.019	1000.0	-1000.0	0.016	-1000.0
Arf6 signaling events	17.0	1070.0	62.0	-0.029	0.056	1000.0	-1000.0	-0.033	-1000.0
BMP receptor signaling	17.0	1437.0	81.0	-0.048	0.049	1000.0	-1000.0	-0.014	-1000.0
Effects of Botulinum toxin	17.0	444.0	26.0	-0.018	0.041	1000.0	-1000.0	-0.0	-1000.0
Syndecan-4-mediated signaling events	17.0	1187.0	67.0	-0.048	0.037	1000.0	-1000.0	-0.026	-1000.0
Class IB PI3K non-lipid kinase events	17.0	51.0	3.0	-0.007	0.007	1000.0	-1000.0	-0.021	-1000.0
HIF-1-alpha transcription factor network	16.0	1216.0	76.0	-0.022	0.065	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by PTP1B	16.0	1254.0	76.0	-0.057	0.043	1000.0	-1000.0	-0.023	-1000.0
Reelin signaling pathway	16.0	940.0	56.0	-0.024	0.058	1000.0	-1000.0	-0.017	-1000.0
TRAIL signaling pathway	16.0	776.0	48.0	-0.024	0.043	1000.0	-1000.0	-0.011	-1000.0
Ephrin B reverse signaling	16.0	811.0	48.0	-0.049	0.039	1000.0	-1000.0	-0.029	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	15.0	1307.0	85.0	-0.029	0.039	1000.0	-1000.0	-0.026	-1000.0
amb2 Integrin signaling	15.0	1234.0	82.0	-0.029	0.045	1000.0	-1000.0	-0.018	-1000.0
Ceramide signaling pathway	15.0	1157.0	76.0	-0.037	0.051	1000.0	-1000.0	-0.017	-1000.0
IL2 signaling events mediated by PI3K	15.0	872.0	58.0	-0.087	0.042	1000.0	-1000.0	-0.03	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	15.0	688.0	45.0	-0.044	0.058	1000.0	-1000.0	-0.018	-1000.0
Plasma membrane estrogen receptor signaling	15.0	1291.0	86.0	-0.113	0.084	1000.0	-1000.0	-0.032	-1000.0
Signaling events mediated by the Hedgehog family	14.0	740.0	52.0	-0.029	0.045	1000.0	-1000.0	-0.014	-1000.0
Fc-epsilon receptor I signaling in mast cells	14.0	1380.0	97.0	-0.043	0.049	1000.0	-1000.0	-0.041	-1000.0
S1P5 pathway	14.0	246.0	17.0	-0.026	0.033	1000.0	-1000.0	-0.003	-1000.0
Class I PI3K signaling events	14.0	1035.0	73.0	-0.095	0.05	1000.0	-1000.0	-0.019	-1000.0
Ras signaling in the CD4+ TCR pathway	14.0	240.0	17.0	-0.021	0.051	1000.0	-1000.0	-0.012	-1000.0
ErbB2/ErbB3 signaling events	13.0	862.0	65.0	-0.032	0.041	1000.0	-1000.0	-0.05	-1000.0
ceramide signaling pathway	13.0	660.0	49.0	-0.026	0.041	1000.0	-1000.0	-0.014	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	13.0	726.0	52.0	-0.051	0.058	1000.0	-1000.0	-0.02	-1000.0
IFN-gamma pathway	12.0	867.0	68.0	-0.033	0.038	1000.0	-1000.0	-0.03	-1000.0
Signaling mediated by p38-gamma and p38-delta	12.0	186.0	15.0	-0.017	0.027	1000.0	-1000.0	-0.018	-1000.0
IL2 signaling events mediated by STAT5	12.0	269.0	22.0	-0.037	0.029	1000.0	-1000.0	-0.013	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	12.0	1453.0	120.0	-0.076	0.07	1000.0	-1000.0	-0.029	-1000.0
LPA4-mediated signaling events	11.0	134.0	12.0	-0.041	0.006	1000.0	-1000.0	-0.017	-1000.0
Syndecan-2-mediated signaling events	11.0	793.0	69.0	-0.014	0.043	1000.0	-1000.0	-0.026	-1000.0
IGF1 pathway	11.0	641.0	57.0	-0.025	0.06	1000.0	-1000.0	-0.02	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	10.0	559.0	54.0	-0.022	0.04	1000.0	-1000.0	-0.019	-1000.0
PDGFR-alpha signaling pathway	10.0	453.0	44.0	-0.019	0.055	1000.0	-1000.0	-0.016	-1000.0
IL1-mediated signaling events	10.0	663.0	62.0	-0.009	0.073	1000.0	-1000.0	-0.019	-1000.0
S1P1 pathway	10.0	375.0	36.0	-0.058	0.028	1000.0	-1000.0	-0.021	-1000.0
TCGA08_p53	10.0	73.0	7.0	-0.01	0.024	1000.0	-1000.0	-0.003	-1000.0
Regulation of p38-alpha and p38-beta	10.0	554.0	54.0	-0.056	0.058	1000.0	-1000.0	-0.033	-1000.0
Regulation of nuclear SMAD2/3 signaling	9.0	1256.0	136.0	-0.293	0.07	1000.0	-1000.0	-0.026	-1000.0
Cellular roles of Anthrax toxin	9.0	387.0	39.0	-0.03	0.028	1000.0	-1000.0	-0.022	-1000.0
Presenilin action in Notch and Wnt signaling	9.0	556.0	61.0	-0.01	0.072	1000.0	-1000.0	-0.034	-1000.0
FOXA2 and FOXA3 transcription factor networks	9.0	448.0	46.0	-0.161	0.034	1000.0	-1000.0	-0.056	-1000.0
EPO signaling pathway	9.0	513.0	55.0	-0.001	0.049	1000.0	-1000.0	-0.018	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	9.0	367.0	37.0	-0.032	0.047	1000.0	-1000.0	-0.022	-1000.0
Paxillin-dependent events mediated by a4b1	9.0	341.0	36.0	-0.037	0.047	1000.0	-1000.0	-0.021	-1000.0
Canonical Wnt signaling pathway	9.0	487.0	51.0	-0.023	0.063	1000.0	-1000.0	-0.022	-1000.0
Nongenotropic Androgen signaling	9.0	488.0	52.0	-0.05	0.043	1000.0	-1000.0	-0.017	-1000.0
S1P3 pathway	9.0	382.0	42.0	-0.025	0.045	1000.0	-1000.0	-0.021	-1000.0
PDGFR-beta signaling pathway	9.0	967.0	97.0	-0.056	0.062	1000.0	-1000.0	-0.032	-1000.0
Visual signal transduction: Rods	9.0	486.0	52.0	-0.0	0.046	1000.0	-1000.0	-0.008	-1000.0
Sphingosine 1-phosphate (S1P) pathway	8.0	242.0	28.0	-0.026	0.043	1000.0	-1000.0	-0.01	-1000.0
Rapid glucocorticoid signaling	8.0	178.0	20.0	-0.008	0.028	1000.0	-1000.0	-0.0	-1000.0
FOXM1 transcription factor network	8.0	427.0	51.0	-0.016	0.081	1000.0	-1000.0	-0.049	-1000.0
Regulation of Androgen receptor activity	8.0	613.0	70.0	-0.102	0.037	1000.0	-1000.0	-0.029	-1000.0
Coregulation of Androgen receptor activity	7.0	573.0	76.0	-0.071	0.048	1000.0	-1000.0	-0.026	-1000.0
ErbB4 signaling events	7.0	506.0	69.0	-0.07	0.067	1000.0	-1000.0	-0.019	-1000.0
Hedgehog signaling events mediated by Gli proteins	7.0	479.0	65.0	-0.046	0.067	1000.0	-1000.0	-0.025	-1000.0
mTOR signaling pathway	7.0	395.0	53.0	-0.035	0.032	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by HDAC Class III	7.0	315.0	40.0	-0.054	0.046	1000.0	-1000.0	-0.038	-1000.0
Retinoic acid receptors-mediated signaling	7.0	435.0	58.0	-0.039	0.054	1000.0	-1000.0	-0.024	-1000.0
Atypical NF-kappaB pathway	7.0	231.0	31.0	-0.017	0.036	1000.0	-1000.0	-0.004	-1000.0
TCGA08_rtk_signaling	7.0	206.0	26.0	-0.021	0.062	1000.0	-1000.0	-0.008	-1000.0
IL6-mediated signaling events	7.0	579.0	75.0	-0.033	0.081	1000.0	-1000.0	-0.043	-1000.0
Insulin Pathway	7.0	538.0	74.0	-0.081	0.071	1000.0	-1000.0	-0.038	-1000.0
HIF-2-alpha transcription factor network	6.0	300.0	43.0	-0.108	0.11	1000.0	-1000.0	-0.037	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	6.0	502.0	83.0	-0.034	0.053	1000.0	-1000.0	-0.014	-1000.0
Regulation of Telomerase	6.0	670.0	102.0	-0.09	0.057	1000.0	-1000.0	-0.016	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	6.0	201.0	33.0	-0.002	0.061	1000.0	-1000.0	-0.024	-1000.0
Aurora B signaling	6.0	453.0	67.0	-0.067	0.065	1000.0	-1000.0	-0.033	-1000.0
Visual signal transduction: Cones	5.0	215.0	38.0	-0.012	0.052	1000.0	-1000.0	-0.003	-1000.0
Arf6 downstream pathway	5.0	255.0	43.0	-0.039	0.048	1000.0	-1000.0	-0.031	-1000.0
Syndecan-3-mediated signaling events	5.0	193.0	35.0	-0.0	0.072	1000.0	-1000.0	-0.01	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	5.0	644.0	125.0	-0.014	0.067	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by PRL	5.0	191.0	34.0	-0.023	0.046	1000.0	-1000.0	-0.027	-1000.0
p38 MAPK signaling pathway	5.0	228.0	44.0	-0.039	0.046	1000.0	-1000.0	-0.01	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	4.0	167.0	34.0	-0.042	0.072	1000.0	-1000.0	-0.03	-1000.0
Canonical NF-kappaB pathway	4.0	176.0	39.0	-0.007	0.059	1000.0	-1000.0	-0.016	-1000.0
BARD1 signaling events	4.0	237.0	57.0	-0.054	0.061	1000.0	-1000.0	-0.043	-1000.0
PLK2 and PLK4 events	4.0	14.0	3.0	0.005	-1000.0	1000.0	-1000.0	-0.002	-1000.0
PLK1 signaling events	4.0	416.0	85.0	-0.007	0.051	1000.0	-1000.0	-0.03	-1000.0
Class I PI3K signaling events mediated by Akt	4.0	311.0	68.0	-0.038	0.052	1000.0	-1000.0	-0.016	-1000.0
FoxO family signaling	4.0	319.0	64.0	-0.183	0.041	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by HDAC Class I	3.0	334.0	104.0	-0.053	0.067	1000.0	-1000.0	-0.037	-1000.0
Arf6 trafficking events	3.0	220.0	71.0	-0.039	0.052	1000.0	-1000.0	-0.031	-1000.0
VEGFR1 specific signals	3.0	177.0	56.0	-0.031	0.053	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class II	2.0	179.0	75.0	-0.03	0.07	1000.0	-1000.0	-0.018	-1000.0
Circadian rhythm pathway	2.0	48.0	22.0	-0.007	0.043	1000.0	-1000.0	-0.032	-1000.0
Aurora A signaling	2.0	174.0	60.0	-0.024	0.06	1000.0	-1000.0	-0.004	-1000.0
Aurora C signaling	2.0	15.0	7.0	-0.0	0.047	1000.0	-1000.0	-0.004	-1000.0
Insulin-mediated glucose transport	2.0	86.0	32.0	-0.016	0.05	1000.0	-1000.0	-0.014	-1000.0
Arf1 pathway	1.0	100.0	54.0	-0.001	0.047	1000.0	-1000.0	-0.008	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	16.0	23.0	0.004	0.056	1000.0	-1000.0	-0.005	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	9.0	27.0	-0.01	0.067	1000.0	-1000.0	-0.022	-1000.0
Alternative NF-kappaB pathway	0.0	3.0	13.0	-0.0	0.072	1000.0	-1000.0	-0.0	-1000.0
Total	1780	104811	7203	-7.7544140248	-993.232269628	131000	-131000	-2.98541281093	-131000