Molecular subtypes CN_CNMF METHLYATION_CNMF MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nCNV (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Chi-square test_P Chi-square test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Amp Peak 1(1p36.22) 0 (0%) 270 1.1915e-07 6.02e-05 0.0030392 0.845 0.013782 1 0.24924 1 0.20806 1 0.10516 1 0.74119 1 0.070597 1 Amp Peak 2(1q21.3) 0 (0%) 198 4.5492e-20 2.7e-17 4.3167e-11 2.39e-08 4.8009e-08 2.46e-05 0.0022228 0.638 1.8124e-08 9.39e-06 2.284e-09 1.22e-06 6.8512e-07 0.000334 1.4763e-08 7.68e-06 Amp Peak 3(1q42.3) 0 (0%) 201 5.5225e-14 3.18e-11 1.152e-07 5.83e-05 1.103e-05 0.00494 0.017014 1 2.4133e-09 1.28e-06 1.9545e-09 1.04e-06 2.377e-05 0.0103 1.0203e-06 0.000496 Amp Peak 4(3q27.1) 0 (0%) 203 1.2062e-05 0.00537 0.0036338 0.974 0.28945 1 0.12858 1 0.053729 1 0.0042664 1 0.68741 1 0.0050346 1 Amp Peak 5(5p13.1) 0 (0%) 219 1.645e-14 9.54e-12 2.0918e-07 0.000105 5.9517e-05 0.0247 0.031849 1 0.00051422 0.174 2.4627e-06 0.00117 0.0004273 0.147 2.4345e-06 0.00116 Amp Peak 6(6p21.1) 0 (0%) 226 3.0956e-17 1.83e-14 2.191e-10 1.2e-07 0.00068661 0.228 0.11385 1 1.7666e-05 0.0077 5.5651e-07 0.000274 2.4314e-05 0.0105 3.9014e-07 0.000193 Amp Peak 7(6q12) 0 (0%) 246 2.9755e-09 1.57e-06 2.3067e-08 1.19e-05 0.00015986 0.0611 0.002902 0.819 8.1202e-05 0.0331 2.7086e-05 0.0116 0.00033998 0.12 2.1125e-05 0.00917 Amp Peak 8(6q21) 0 (0%) 250 4.3813e-09 2.3e-06 1.68e-05 0.00736 0.004324 1 0.013569 1 0.0079835 1 0.0058986 1 0.001422 0.435 0.00085784 0.275 Amp Peak 9(7p22.3) 0 (0%) 149 8.2502e-14 4.74e-11 1.739e-05 0.0076 0.011562 1 0.62546 1 0.019979 1 0.00033246 0.118 0.077273 1 0.00024503 0.0902 Amp Peak 10(7p11.2) 0 (0%) 163 4.2298e-12 2.37e-09 0.0099491 1 0.063523 1 0.81642 1 0.11998 1 0.010224 1 0.086589 1 0.0039373 1 Amp Peak 11(7q21.2) 0 (0%) 169 2.3593e-11 1.31e-08 0.019553 1 0.27644 1 0.82814 1 0.30082 1 0.042023 1 0.38688 1 0.1286 1 Amp Peak 12(8p23.1) 0 (0%) 185 3.3948e-13 1.94e-10 0.0029823 0.832 0.45355 1 0.0082619 1 0.046643 1 0.32573 1 0.24805 1 0.050258 1 Amp Peak 13(8q24.21) 0 (0%) 101 2.6319e-06 0.00125 4.4627e-05 0.0187 0.05759 1 0.031773 1 0.002896 0.819 0.00038772 0.135 0.0057629 1 6.7943e-05 0.028 Amp Peak 14(9p24.1) 0 (0%) 257 0.36393 1 0.08784 1 0.63334 1 0.30612 1 0.27658 1 0.30315 1 0.29669 1 0.04479 1 Amp Peak 15(9q34.3) 0 (0%) 232 2.8621e-07 0.000143 0.0051731 1 0.022009 1 0.54972 1 0.050514 1 0.19085 1 0.068552 1 0.030136 1 Amp Peak 16(10q22.2) 0 (0%) 250 9.4116e-08 4.78e-05 0.074625 1 0.0055022 1 0.0094961 1 0.072997 1 0.056734 1 0.0068258 1 0.03792 1 Amp Peak 17(10q26.13) 0 (0%) 245 1.1825e-05 0.00527 0.0012812 0.395 0.0086906 1 0.017741 1 0.12349 1 0.0049281 1 0.23127 1 0.0087423 1 Amp Peak 18(11p13) 0 (0%) 252 0.0065816 1 0.1863 1 0.016608 1 0.0052935 1 0.00026617 0.0972 0.00038663 0.135 0.14717 1 0.0086216 1 Amp Peak 19(11q13.3) 0 (0%) 238 3.2708e-05 0.0139 0.19377 1 0.48273 1 0.29728 1 0.0018206 0.535 0.013216 1 0.0027082 0.769 0.16329 1 Amp Peak 20(12p12.1) 0 (0%) 220 0.00030362 0.109 0.011401 1 0.3876 1 0.79822 1 0.13002 1 0.060622 1 0.0052193 1 0.1152 1 Amp Peak 21(12q15) 0 (0%) 229 0.0080306 1 0.00048876 0.167 0.47928 1 0.41193 1 0.030134 1 0.019075 1 0.07569 1 0.22078 1 Amp Peak 22(13q12.3) 0 (0%) 190 7.0689e-10 3.82e-07 4.545e-06 0.00212 0.043159 1 0.79605 1 0.00037042 0.129 0.0001188 0.047 0.0035835 0.964 0.00016115 0.0614 Amp Peak 23(13q22.1) 0 (0%) 185 1.5441e-08 8.01e-06 4.1325e-05 0.0174 0.0016812 0.5 0.040302 1 2.9805e-07 0.000148 6.0113e-07 0.000295 0.0019278 0.559 1.4788e-06 0.000716 Amp Peak 24(15q26.1) 0 (0%) 237 1.0316e-13 5.91e-11 0.00044114 0.151 7.5946e-05 0.0311 0.00088255 0.281 0.045226 1 0.008776 1 0.029306 1 0.020857 1 Amp Peak 25(17q12) 0 (0%) 214 9.5399e-13 5.39e-10 2.6762e-06 0.00127 5.7556e-05 0.024 0.00071741 0.235 6.0868e-06 0.00279 5.9154e-06 0.00272 0.086189 1 0.0061564 1 Amp Peak 26(18q11.2) 0 (0%) 216 3.3105e-06 0.00156 0.00030593 0.11 0.021393 1 0.0942 1 0.0062983 1 0.017095 1 0.19627 1 0.07314 1 Amp Peak 27(19q12) 0 (0%) 216 1.6674e-15 9.79e-13 1.0052e-10 5.54e-08 1.1953e-09 6.43e-07 2.9769e-06 0.00141 8.1336e-12 4.53e-09 1.6521e-13 9.45e-11 0.00058285 0.195 7.1636e-13 4.07e-10 Amp Peak 28(20q13.2) 0 (0%) 105 5.6288e-21 3.34e-18 4.2366e-12 2.37e-09 5.1812e-07 0.000255 9.0402e-06 0.0041 5.5259e-10 3e-07 2.1521e-12 1.21e-09 0.0036425 0.974 6.9078e-09 3.62e-06 Amp Peak 29(Xq27.3) 0 (0%) 246 0.00015507 0.0594 0.19077 1 0.066741 1 0.73576 1 0.11105 1 0.61518 1 0.0046258 1 0.0085816 1 Del Peak 1(1p36.11) 0 (0%) 223 4.2015e-15 2.45e-12 0.0003959 0.137 0.00088296 0.281 0.0088707 1 0.00012859 0.0499 0.00011945 0.0472 0.012807 1 0.0019149 0.557 Del Peak 2(1p13.2) 0 (0%) 247 5.3952e-12 3.01e-09 0.0066913 1 0.0034417 0.929 0.013125 1 0.00028019 0.102 0.0013406 0.412 0.24083 1 0.015134 1 Del Peak 3(1q44) 0 (0%) 283 0.018536 1 0.0074751 1 0.57281 1 0.65077 1 0.12983 1 0.079051 1 0.12292 1 0.082569 1 Del Peak 4(2q32.1) 0 (0%) 264 0.0089459 1 0.10796 1 0.46005 1 0.89987 1 0.033332 1 0.13314 1 0.57061 1 0.74247 1 Del Peak 5(2q37.2) 0 (0%) 259 0.0001908 0.0717 0.0073601 1 0.064203 1 0.44964 1 0.001678 0.5 8.7564e-05 0.0355 0.07059 1 0.0040206 1 Del Peak 6(3p26.1) 0 (0%) 222 2.6431e-10 1.44e-07 0.0003067 0.11 0.0019934 0.576 0.1604 1 0.00014336 0.0552 6.3217e-05 0.0261 0.19036 1 0.00071926 0.235 Del Peak 7(3p14.2) 0 (0%) 204 9.3271e-13 5.28e-10 1.2366e-06 6e-04 0.00050183 0.171 0.0017691 0.524 7.4534e-06 0.0034 1.7526e-06 0.000841 0.032786 1 4.1728e-06 0.00196 Del Peak 8(3q26.31) 0 (0%) 272 4.23e-06 0.00198 0.00010717 0.0427 0.00026711 0.0972 0.0093143 1 0.00052135 0.176 0.021139 1 0.03276 1 0.0068655 1 Del Peak 9(4p16.3) 0 (0%) 194 2.8949e-10 1.57e-07 0.00099107 0.311 9.8703e-05 0.0394 0.00062418 0.208 1.5872e-05 0.00697 0.00021172 0.079 2.5663e-05 0.011 1.2511e-05 0.00555 Del Peak 10(4q22.1) 0 (0%) 171 6.7225e-19 3.98e-16 3.8453e-07 0.000191 0.041935 1 0.034178 1 9.2007e-06 0.00415 0.00036895 0.129 0.0057841 1 0.00096207 0.304 Del Peak 11(4q34.3) 0 (0%) 179 1.0706e-14 6.22e-12 1.8722e-06 0.000897 0.00010919 0.0433 0.0091478 1 1.6944e-06 0.000815 1.8388e-05 0.008 0.0012599 0.391 4.7053e-06 0.00219 Del Peak 12(5q11.2) 0 (0%) 203 6.544e-28 3.93e-25 2.4868e-14 1.44e-11 8.0171e-10 4.33e-07 6.0186e-08 3.08e-05 8.4455e-12 4.7e-09 4.0237e-10 2.18e-07 3.7047e-08 1.9e-05 3.5286e-15 2.06e-12 Del Peak 13(5q23.2) 0 (0%) 213 2.4759e-23 1.48e-20 2.2928e-12 1.29e-09 1.0319e-09 5.56e-07 1.8734e-07 9.44e-05 1.017e-12 5.74e-10 1.9281e-09 1.03e-06 4.8446e-09 2.54e-06 4.7467e-14 2.73e-11 Del Peak 14(6p25.3) 0 (0%) 237 5.0068e-07 0.000247 0.00057609 0.194 0.0046583 1 0.026837 1 9.7208e-05 0.0389 0.00033695 0.119 0.056099 1 0.026274 1 Del Peak 15(6q26) 0 (0%) 244 0.00012761 0.0496 0.071103 1 0.00012381 0.0487 7.495e-05 0.0308 0.14871 1 0.035561 1 0.32949 1 0.33864 1 Del Peak 16(7q31.1) 0 (0%) 262 3.1075e-07 0.000154 0.0011647 0.362 0.14443 1 0.33723 1 0.02201 1 0.2474 1 0.00086279 0.276 0.059102 1 Del Peak 17(7q36.3) 0 (0%) 248 1.8187e-14 1.05e-11 1.3075e-05 0.00579 0.00067715 0.225 0.0046314 1 0.00078106 0.253 3.0573e-05 0.013 0.010853 1 9.56e-05 0.0383 Del Peak 18(8p23.2) 0 (0%) 229 4.3014e-14 2.48e-11 8.1061e-06 0.00368 0.0031363 0.869 0.0002321 0.0859 5.921e-05 0.0246 1.5805e-05 0.00695 0.040747 1 9.2321e-06 0.00415 Del Peak 19(9p23) 0 (0%) 186 2.6605e-15 1.56e-12 8.7608e-05 0.0355 0.00012689 0.0495 0.001267 0.392 0.0014528 0.443 5.5478e-05 0.0232 0.075755 1 0.0022152 0.638 Del Peak 20(9p21.3) 0 (0%) 188 6.2942e-16 3.7e-13 1.9238e-10 1.05e-07 2.5816e-07 0.000129 0.0001949 0.0731 0.00018835 0.071 6.2271e-06 0.00285 0.0070417 1 8.9911e-05 0.0362 Del Peak 21(9q21.11) 0 (0%) 233 2.9745e-08 1.53e-05 0.00022338 0.0829 0.011224 1 0.018466 1 0.025822 1 0.00036267 0.127 0.0010053 0.314 2.2544e-05 0.00976 Del Peak 22(10p15.1) 0 (0%) 268 0.00012398 0.0487 0.27709 1 0.29077 1 0.62744 1 0.23814 1 0.34574 1 0.079397 1 0.15594 1 Del Peak 23(10q22.3) 0 (0%) 257 2.4321e-09 1.29e-06 0.0007179 0.235 0.026603 1 0.078866 1 0.0032908 0.901 0.00016834 0.0638 0.020347 1 0.00028473 0.103 Del Peak 24(10q23.31) 0 (0%) 233 2.7184e-12 1.53e-09 5.2253e-06 0.00242 0.013634 1 0.017926 1 3.0702e-05 0.013 1.1649e-05 0.00521 0.00031546 0.112 0.00031004 0.111 Del Peak 25(11p15.4) 0 (0%) 247 2.9626e-08 1.53e-05 8.053e-06 0.00366 0.10151 1 0.037404 1 0.0016707 0.5 0.0015584 0.474 0.22194 1 0.0032879 0.901 Del Peak 26(11q23.2) 0 (0%) 244 0.0002643 0.0967 0.001666 0.5 0.00078019 0.253 0.10265 1 0.28695 1 0.43085 1 0.9349 1 0.20175 1 Del Peak 27(12p13.31) 0 (0%) 256 1.4888e-10 8.16e-08 5.6975e-06 0.00263 4.6428e-06 0.00216 0.00029689 0.107 0.00038876 0.135 0.0022193 0.638 0.019228 1 0.0001539 0.0591 Del Peak 28(13q12.11) 0 (0%) 262 2.323e-06 0.00111 0.12644 1 0.17578 1 0.012354 1 0.54075 1 0.23983 1 0.061936 1 0.11323 1 Del Peak 29(14q21.1) 0 (0%) 235 7.6857e-07 0.000374 0.015925 1 0.0008371 0.27 0.00017534 0.0663 0.00014164 0.0547 0.00016216 0.0616 0.036311 1 0.00023581 0.087 Del Peak 30(14q32.33) 0 (0%) 217 9.2439e-09 4.83e-06 0.042169 1 0.01113 1 8.2413e-05 0.0335 0.034742 1 0.018323 1 0.02744 1 0.0062314 1 Del Peak 31(15q15.1) 0 (0%) 227 6.4387e-13 3.66e-10 2.1075e-07 0.000106 6.0843e-05 0.0252 6.2604e-07 0.000307 1.9828e-09 1.06e-06 2.8166e-08 1.45e-05 0.00055166 0.186 1.0637e-05 0.00478 Del Peak 32(16p13.3) 0 (0%) 248 7.4186e-11 4.1e-08 4.1382e-05 0.0174 1.4599e-05 0.00644 0.00022228 0.0827 1.3938e-05 0.00616 0.0006855 0.228 2.9145e-06 0.00138 1.5289e-06 0.000738 Del Peak 33(16q23.1) 0 (0%) 188 2.2174e-07 0.000111 0.0028933 0.819 0.037893 1 0.058842 1 0.01205 1 0.012873 1 0.01078 1 0.00088065 0.281 Del Peak 34(17p12) 0 (0%) 191 1.8098e-23 1.08e-20 3.2797e-11 1.82e-08 3.9355e-06 0.00185 1.6771e-06 0.000808 6.2053e-08 3.16e-05 1.1496e-07 5.83e-05 9.0532e-06 0.0041 4.0759e-09 2.15e-06 Del Peak 35(17q24.3) 0 (0%) 251 1.3158e-10 7.24e-08 0.00025131 0.0922 0.001839 0.539 0.020431 1 0.0049043 1 0.0064756 1 0.020516 1 0.021227 1 Del Peak 36(18q21.2) 0 (0%) 173 4.4882e-13 2.56e-10 0.0025647 0.731 0.018528 1 0.029398 1 0.0071591 1 0.0041511 1 0.071747 1 0.015916 1 Del Peak 37(19p13.3) 0 (0%) 207 2.3542e-27 1.41e-24 2.3307e-16 1.37e-13 9.1137e-13 5.17e-10 2.023e-15 1.19e-12 2.3894e-22 1.42e-19 9.6904e-24 5.79e-21 3.9687e-05 0.0168 6.1297e-17 3.62e-14 Del Peak 38(19q13.11) 0 (0%) 263 2.6898e-09 1.42e-06 8.4859e-05 0.0345 0.0017907 0.528 0.0029404 0.823 2.4413e-05 0.0105 6.4167e-07 0.000314 0.01404 1 4.8894e-06 0.00227 Del Peak 39(20p12.1) 0 (0%) 254 1.2075e-08 6.3e-06 0.00070056 0.23 0.0033025 0.901 0.040699 1 0.001656 0.5 0.0043534 1 0.050376 1 0.0053136 1 Del Peak 40(20p12.1) 0 (0%) 254 1.2075e-08 6.3e-06 0.00070056 0.23 0.0033025 0.901 0.040699 1 0.001656 0.5 0.0043534 1 0.050376 1 0.0053136 1 Del Peak 41(21q11.2) 0 (0%) 198 1.3864e-10 7.61e-08 2.7064e-05 0.0116 0.00049608 0.169 8.9804e-05 0.0362 0.0018853 0.551 0.00012529 0.049 0.0031953 0.879 0.010788 1 Del Peak 42(21q22.13) 0 (0%) 191 1.5619e-09 8.37e-07 0.00036168 0.127 0.0058892 1 0.00019731 0.0738 0.00069252 0.229 8.025e-05 0.0328 0.10654 1 0.006323 1 Del Peak 43(22q13.31) 0 (0%) 205 9.6794e-15 5.63e-12 0.00013549 0.0524 0.00099263 0.311 0.0031687 0.875 4.364e-05 0.0183 6.4688e-06 0.00296 0.078726 1 0.0001225 0.0483 Del Peak 44(Xp22.2) 0 (0%) 245 1.4414e-09 7.74e-07 0.0016225 0.492 0.05171 1 0.14633 1 0.022794 1 0.00098358 0.31 0.2316 1 0.014215 1 Del Peak 45(Xp21.1) 0 (0%) 254 6.2238e-08 3.17e-05 0.0040678 1 0.17179 1 0.13874 1 0.22161 1 0.36584 1 0.71969 1 0.25932 1 Del Peak 46(Xq21.33) 0 (0%) 264 5.7705e-06 0.00266 0.035216 1 0.074569 1 0.013956 1 0.070249 1 0.21165 1 0.079047 1 0.061823 1