Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.091 0.308 -9999.0 0.0 -0.872 24.0 24.0 IHH -0.076 0.215 -9999.0 0.0 -0.601 29.0 29.0 SHH Np/Cholesterol/GAS1 -0.046 0.159 -9999.0 0.0 -0.64 7.0 7.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.063 0.15 0.633 7.0 -9999.0 0.0 7.0 SMO/beta Arrestin2 -0.048 0.191 -9999.0 0.0 -0.673 8.0 8.0 SMO -0.056 0.201 -9999.0 0.0 -0.585 16.0 16.0 AKT1 -0.007 0.092 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.006 0.117 -9999.0 0.0 -0.741 5.0 5.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.055 0.198 -9999.0 0.0 -0.575 16.0 16.0 STIL -0.115 0.259 -9999.0 0.0 -0.611 35.0 35.0 DHH N/PTCH2 -0.103 0.244 -9999.0 0.0 -0.654 33.0 33.0 DHH N/PTCH1 -0.046 0.176 -9999.0 0.0 -0.636 8.0 8.0 PIK3CA 0.007 0.06 -9999.0 0.0 -0.863 1.0 1.0 DHH 0.002 0.082 -9999.0 0.0 -0.659 3.0 3.0 PTHLH -0.088 0.295 -9999.0 0.0 -1.023 11.0 11.0 determination of left/right symmetry -0.055 0.198 -9999.0 0.0 -0.575 16.0 16.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.087 0.292 -9999.0 0.0 -1.006 11.0 11.0 IHH N/Hhip -0.154 0.264 -9999.0 0.0 -0.524 66.0 66.0 DHH N/Hhip -0.118 0.188 -9999.0 0.0 -0.411 60.0 60.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.055 0.198 -9999.0 0.0 -0.575 16.0 16.0 pancreas development -0.146 0.254 -9999.0 0.0 -0.557 58.0 58.0 HHAT 0.006 0.055 -9999.0 0.0 -0.558 2.0 2.0 PI3K -0.003 0.046 -9999.0 0.0 -0.67 1.0 1.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.019 0.147 -9999.0 0.0 -0.693 9.0 9.0 somite specification -0.055 0.198 -9999.0 0.0 -0.575 16.0 16.0 SHH Np/Cholesterol/PTCH1 -0.072 0.203 -9999.0 0.0 -0.609 16.0 16.0 SHH Np/Cholesterol/PTCH2 -0.108 0.222 -9999.0 0.0 -0.562 32.0 32.0 SHH Np/Cholesterol/Megalin -0.096 0.205 -9999.0 0.0 -0.559 25.0 25.0 SHH -0.043 0.157 -9999.0 0.0 -0.421 30.0 30.0 catabolic process -0.052 0.186 -9999.0 0.0 -0.626 9.0 9.0 SMO/Vitamin D3 -0.071 0.214 -9999.0 0.0 -0.64 16.0 16.0 SHH Np/Cholesterol/Hhip -0.116 0.208 -9999.0 0.0 -0.614 18.0 18.0 LRP2 -0.096 0.276 -9999.0 0.0 -0.787 28.0 28.0 receptor-mediated endocytosis -0.135 0.205 -9999.0 0.0 -0.62 21.0 21.0 SHH Np/Cholesterol/BOC -0.039 0.142 -9999.0 0.0 -0.561 6.0 6.0 SHH Np/Cholesterol/CDO -0.044 0.154 -9999.0 0.0 -0.584 8.0 8.0 mesenchymal cell differentiation 0.129 0.197 0.609 18.0 -9999.0 0.0 18.0 mol:Vitamin D3 -0.071 0.205 -9999.0 0.0 -0.612 16.0 16.0 IHH N/PTCH2 -0.142 0.276 -9999.0 0.0 -0.557 58.0 58.0 CDON -0.014 0.146 -9999.0 0.0 -0.863 6.0 6.0 IHH N/PTCH1 -0.052 0.188 -9999.0 0.0 -0.634 9.0 9.0 Megalin/LRPAP1 -0.08 0.21 -9999.0 0.0 -0.602 28.0 28.0 PTCH2 -0.115 0.305 -9999.0 0.0 -0.843 31.0 31.0 SHH Np/Cholesterol -0.047 0.118 -9999.0 0.0 -0.328 30.0 30.0 PTCH1 -0.052 0.187 -9999.0 0.0 -0.628 9.0 9.0 HHIP -0.146 0.255 -9999.0 0.0 -0.558 58.0 58.0