Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.037 0.132 -9999.0 0.0 -0.463 9.0 9.0 IHH -0.035 0.158 -9999.0 0.0 -0.431 27.0 27.0 SHH Np/Cholesterol/GAS1 -0.011 0.09 -9999.0 0.0 -0.224 29.0 29.0 LRPAP1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.011 0.089 0.223 29.0 -9999.0 0.0 29.0 SMO/beta Arrestin2 -0.03 0.148 -9999.0 0.0 -0.356 28.0 28.0 SMO -0.044 0.141 -9999.0 0.0 -0.37 28.0 28.0 AKT1 -0.028 0.141 -9999.0 0.0 -0.482 13.0 13.0 ARRB2 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.02 0.055 -9999.0 0.0 -0.33 5.0 5.0 ADRBK1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.041 0.14 -9999.0 0.0 -0.365 28.0 28.0 STIL -0.052 0.134 0.183 8.0 -0.375 19.0 27.0 DHH N/PTCH2 0.003 0.092 -9999.0 0.0 -0.213 31.0 31.0 DHH N/PTCH1 -0.016 0.116 -9999.0 0.0 -0.323 12.0 12.0 PIK3CA 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.022 0.046 -9999.0 0.0 -0.355 3.0 3.0 PTHLH -0.047 0.154 -9999.0 0.0 -0.526 10.0 10.0 determination of left/right symmetry -0.041 0.14 -9999.0 0.0 -0.365 28.0 28.0 PIK3R1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.047 0.153 -9999.0 0.0 -0.522 10.0 10.0 IHH N/Hhip -0.079 0.184 -9999.0 0.0 -0.355 59.0 59.0 DHH N/Hhip -0.045 0.14 -9999.0 0.0 -0.276 55.0 55.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.041 0.14 -9999.0 0.0 -0.365 28.0 28.0 pancreas development -0.079 0.18 -9999.0 0.0 -0.387 53.0 53.0 HHAT 0.023 0.041 -9999.0 0.0 -0.388 2.0 2.0 PI3K 0.036 0.015 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.011 0.077 -9999.0 0.0 -0.345 9.0 9.0 somite specification -0.041 0.14 -9999.0 0.0 -0.365 28.0 28.0 SHH Np/Cholesterol/PTCH1 -0.042 0.124 -9999.0 0.0 -0.383 14.0 14.0 SHH Np/Cholesterol/PTCH2 -0.031 0.097 -9999.0 0.0 -0.189 53.0 53.0 SHH Np/Cholesterol/Megalin -0.027 0.099 -9999.0 0.0 -0.202 47.0 47.0 SHH -0.026 0.099 -9999.0 0.0 -0.28 27.0 27.0 catabolic process -0.03 0.119 -9999.0 0.0 -0.281 32.0 32.0 SMO/Vitamin D3 -0.046 0.141 -9999.0 0.0 -0.408 16.0 16.0 SHH Np/Cholesterol/Hhip -0.06 0.137 -9999.0 0.0 -0.256 62.0 62.0 LRP2 -0.019 0.118 -9999.0 0.0 -0.315 28.0 28.0 receptor-mediated endocytosis -0.064 0.144 -9999.0 0.0 -0.405 20.0 20.0 SHH Np/Cholesterol/BOC -0.01 0.087 -9999.0 0.0 -0.214 30.0 30.0 SHH Np/Cholesterol/CDO -0.01 0.084 -9999.0 0.0 -0.209 29.0 29.0 mesenchymal cell differentiation 0.06 0.136 0.255 62.0 -9999.0 0.0 62.0 mol:Vitamin D3 -0.037 0.13 0.196 8.0 -0.384 14.0 22.0 IHH N/PTCH2 -0.038 0.127 -9999.0 0.0 -0.242 56.0 56.0 CDON 0.017 0.054 -9999.0 0.0 -0.291 6.0 6.0 IHH N/PTCH1 -0.023 0.124 -9999.0 0.0 -0.283 32.0 32.0 Megalin/LRPAP1 0.005 0.088 -9999.0 0.0 -0.219 27.0 27.0 PTCH2 -0.017 0.112 -9999.0 0.0 -0.294 29.0 29.0 SHH Np/Cholesterol -0.014 0.077 -9999.0 0.0 -0.211 27.0 27.0 PTCH1 -0.03 0.12 -9999.0 0.0 -0.281 32.0 32.0 HHIP -0.079 0.181 -9999.0 0.0 -0.388 53.0 53.0