Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.112 0.262 -9999.0 0.0 -0.692 36.0 36.0 IHH -0.207 0.371 -9999.0 0.0 -0.844 122.0 122.0 SHH Np/Cholesterol/GAS1 -0.108 0.208 -9999.0 0.0 -0.518 98.0 98.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.107 0.206 0.514 98.0 -9999.0 0.0 98.0 SMO/beta Arrestin2 -0.098 0.244 -9999.0 0.0 -0.486 125.0 125.0 SMO -0.11 0.256 -9999.0 0.0 -0.517 126.0 126.0 AKT1 -0.028 0.125 -9999.0 0.0 -0.665 2.0 2.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.002 0.113 -9999.0 0.0 -0.823 9.0 9.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.108 0.253 -9999.0 0.0 -0.509 126.0 126.0 STIL -0.08 0.201 -9999.0 0.0 -0.606 18.0 18.0 DHH N/PTCH2 -0.107 0.242 -9999.0 0.0 -0.645 81.0 81.0 DHH N/PTCH1 -0.103 0.229 -9999.0 0.0 -0.456 129.0 129.0 PIK3CA 0.008 0.066 -9999.0 0.0 -0.823 3.0 3.0 DHH 0.006 0.076 -9999.0 0.0 -0.823 4.0 4.0 PTHLH -0.161 0.373 -9999.0 0.0 -1.177 36.0 36.0 determination of left/right symmetry -0.108 0.253 -9999.0 0.0 -0.509 126.0 126.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.159 0.366 -9999.0 0.0 -1.15 36.0 36.0 IHH N/Hhip -0.383 0.401 -9999.0 0.0 -0.739 256.0 256.0 DHH N/Hhip -0.247 0.312 -9999.0 0.0 -0.637 188.0 188.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.108 0.253 -9999.0 0.0 -0.509 126.0 126.0 pancreas development -0.311 0.403 -9999.0 0.0 -0.816 188.0 188.0 HHAT 0.012 0.038 -9999.0 0.0 -0.823 1.0 1.0 PI3K -0.004 0.049 -9999.0 0.0 -0.632 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.154 0.334 -9999.0 0.0 -0.823 97.0 97.0 somite specification -0.108 0.253 -9999.0 0.0 -0.509 126.0 126.0 SHH Np/Cholesterol/PTCH1 -0.09 0.206 -9999.0 0.0 -0.62 18.0 18.0 SHH Np/Cholesterol/PTCH2 -0.089 0.191 -9999.0 0.0 -0.515 80.0 80.0 SHH Np/Cholesterol/Megalin -0.139 0.228 -9999.0 0.0 -0.519 128.0 128.0 SHH 0.007 0.05 -9999.0 0.0 -0.632 1.0 1.0 catabolic process -0.117 0.251 -9999.0 0.0 -0.514 125.0 125.0 SMO/Vitamin D3 -0.094 0.225 -9999.0 0.0 -0.657 18.0 18.0 SHH Np/Cholesterol/Hhip -0.202 0.246 -9999.0 0.0 -0.511 187.0 187.0 LRP2 -0.205 0.368 -9999.0 0.0 -0.823 127.0 127.0 receptor-mediated endocytosis -0.2 0.236 -9999.0 0.0 -0.718 48.0 48.0 SHH Np/Cholesterol/BOC -0.015 0.078 -9999.0 0.0 -0.524 10.0 10.0 SHH Np/Cholesterol/CDO -0.153 0.233 -9999.0 0.0 -0.516 141.0 141.0 mesenchymal cell differentiation 0.2 0.244 0.507 187.0 -9999.0 0.0 187.0 mol:Vitamin D3 -0.09 0.209 -9999.0 0.0 -0.627 18.0 18.0 IHH N/PTCH2 -0.234 0.348 -9999.0 0.0 -0.667 179.0 179.0 CDON -0.228 0.379 -9999.0 0.0 -0.823 140.0 140.0 IHH N/PTCH1 -0.119 0.254 -9999.0 0.0 -0.521 125.0 125.0 Megalin/LRPAP1 -0.165 0.278 -9999.0 0.0 -0.632 127.0 127.0 PTCH2 -0.123 0.309 -9999.0 0.0 -0.823 79.0 79.0 SHH Np/Cholesterol -0.006 0.036 -9999.0 0.0 -0.513 1.0 1.0 PTCH1 -0.117 0.252 -9999.0 0.0 -0.516 125.0 125.0 HHIP -0.311 0.404 -9999.0 0.0 -0.818 188.0 188.0