Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.023 0.079 0.461 11.0 -9999.0 0.0 11.0 EGFR 0.021 0.064 -9999.0 0.0 -0.676 4.0 4.0 EPHA2 0.026 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 0.033 0.069 0.431 12.0 -9999.0 0.0 12.0 CTNNB1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.053 0.013 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 0.001 0.114 -9999.0 0.0 -0.538 19.0 19.0 CTNND1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.025 0.052 0.396 8.0 -9999.0 0.0 8.0 regulation of calcium-dependent cell-cell adhesion -0.009 0.057 0.393 6.0 -9999.0 0.0 6.0 EGF -0.073 0.243 -9999.0 0.0 -0.671 68.0 68.0 NCKAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.043 0.174 -9999.0 0.0 -0.53 50.0 50.0 cortical microtubule organization 0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.014 0.052 0.387 8.0 -9999.0 0.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.061 0.018 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP 0.006 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.062 0.024 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.014 0.028 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.021 0.021 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.067 0.027 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.009 0.143 -9999.0 0.0 -0.358 69.0 69.0 RhoA/GDP 0.057 0.017 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.022 0.056 0.399 9.0 -9999.0 0.0 9.0 IGF-1R heterotetramer 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.13 0.29 -9999.0 0.0 -0.673 107.0 107.0 DIAPH1 0.051 0.045 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway -0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP 0.006 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.022 0.056 0.401 9.0 -9999.0 0.0 9.0 EFNA1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.012 0.054 0.354 3.0 -0.359 6.0 9.0 Ephrin A1/EPHA2 0.047 0.019 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.014 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.01 0.058 0.395 6.0 -9999.0 0.0 6.0 HGF/MET -0.006 0.147 -9999.0 0.0 -0.376 63.0 63.0 HGF -0.075 0.246 -9999.0 0.0 -0.676 69.0 69.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.07 0.137 0.392 50.0 -0.326 1.0 51.0 KIAA1543 0.014 0.053 0.367 8.0 -0.353 1.0 9.0 KIFC3 0.022 0.024 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.025 0.038 0.356 4.0 -9999.0 0.0 4.0 NCK1/GIT1 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.022 0.024 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.026 0.053 0.399 8.0 -9999.0 0.0 8.0 LIMA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.045 0.103 0.431 23.0 -9999.0 0.0 23.0 adherens junction assembly 0.028 0.093 0.48 13.0 -0.562 1.0 14.0 IGF-1R heterotetramer/IGF1 -0.038 0.167 -9999.0 0.0 -0.358 101.0 101.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.029 0.072 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 0.026 0.053 0.376 8.0 -0.37 1.0 9.0 mol:GTP 0.059 0.024 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.033 0.067 0.482 7.0 -9999.0 0.0 7.0 cortical actin cytoskeleton stabilization 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.022 0.056 0.399 9.0 -9999.0 0.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0