Clinical Features	MRNA_CNMF		MRNA_CHIERARCHICAL		CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Chi-square test_P	Chi-square test_Q	Fisher's exact test_P	Fisher's exact test_Q	Chi-square test_P	Chi-square test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
PPP2R1A	27 (11%)	221	0.075984	1	0.0518	1	0.021488	1	0.021262	1	0.1409	1	0.31271	1	0.0025094	0.911	0.0021451	0.783	0.013857	1	0.0019384	0.709	0.22506	1	0.044815	1
PIK3CA	132 (53%)	116	0.85887	1	0.20272	1	0.54225	1	0.69196	1	0.36637	1	0.36468	1	0.77158	1	0.76557	1	0.19455	1	0.43994	1	0.29269	1	0.33119	1
CTNNB1	74 (30%)	174	4.9035e-07	0.000189	0.0011513	0.426	5.2999e-06	0.00204	0.0041642	1	1.289e-10	5.05e-08	0.11185	1	1.1794e-15	4.69e-13	8.4501e-30	3.44e-27	2.1166e-14	8.38e-12	3.3752e-07	0.000131	0.061905	1	0.39034	1
PIK3R1	83 (33%)	165	0.06672	1	0.02209	1	0.0017725	0.651	3.9942e-05	0.0151	0.6489	1	0.87686	1	1.1483e-05	0.0044	0.000937	0.348	0.025108	1	0.022529	1	0.15313	1	0.027391	1
PRKAR1B	4 (2%)	244	NA	NA	NA	NA	0.96324	1	0.50611	1	0.88699	1	1	1	0.69757	1	0.4171	1	0.83178	1	0.1991	1	0.78556	1	0.30299	1
PTEN	161 (65%)	87	0.0042787	1	0.0003568	0.133	3.4264e-21	1.38e-18	3.3538e-12	1.32e-09	0.025685	1	0.18335	1	7.0384e-22	2.84e-19	6.6915e-16	2.67e-13	1.5424e-14	6.12e-12	3.0738e-16	1.23e-13	1.4924e-08	5.82e-06	3.962e-11	1.56e-08
RPL22	31 (12%)	217	0.053072	1	0.16015	1	0.01014	1	0.0091252	1	0.015268	1	0.26035	1	0.40737	1	0.12054	1	0.3423	1	0.0101	1	0.58423	1	0.43824	1
KRAS	53 (21%)	195	0.203	1	0.00074173	0.276	0.002258	0.822	0.14274	1	0.29674	1	0.85484	1	0.54312	1	0.00027895	0.105	0.11727	1	0.032614	1	0.12296	1	0.41738	1
TP53	69 (28%)	179	3.8766e-05	0.0147	1.7188e-07	6.67e-05	8.505e-31	3.47e-28	3.6096e-12	1.42e-09	2.0063e-05	0.00766	0.0014012	0.517	5.7593e-26	2.33e-23	1.2712e-27	5.16e-25	9.8108e-18	3.93e-15	2.8954e-22	1.17e-19	2.2367e-09	8.75e-07	2.0821e-08	8.1e-06
FBXW7	39 (16%)	209	0.225	1	0.69213	1	0.2015	1	0.1319	1	0.10644	1	0.10694	1	0.067952	1	0.00012369	0.0466	0.76088	1	0.18611	1	0.14371	1	0.11541	1
CTCF	45 (18%)	203	0.14875	1	0.42097	1	9.1942e-05	0.0348	0.052815	1	0.078376	1	0.84803	1	0.00033386	0.125	0.00015821	0.0595	0.0055466	1	0.0086157	1	0.009008	1	0.035202	1
ARID1A	83 (33%)	165	0.26532	1	0.011471	1	3.8073e-06	0.00147	0.22496	1	0.02713	1	1	1	0.042119	1	0.08357	1	0.035674	1	0.01254	1	0.04651	1	0.0052779	1
SPOP	21 (8%)	227	0.34932	1	1	1	0.4833	1	0.32618	1	0.83433	1	0.41497	1	0.74243	1	1	1	0.95807	1	0.73247	1	0.66574	1	0.87638	1
ARID5B	29 (12%)	219	0.96088	1	0.45933	1	0.034374	1	0.13684	1	0.16398	1	0.1818	1	0.32572	1	0.05735	1	0.33335	1	0.20567	1	0.8591	1	0.25043	1
FGFR2	31 (12%)	217	0.38513	1	0.29313	1	0.38861	1	0.89754	1	0.96987	1	0.82869	1	0.91241	1	0.068531	1	0.45732	1	0.23521	1	0.73214	1	1	1
CCND1	15 (6%)	233	0.631	1	0.83347	1	0.07025	1	0.49446	1	0.37433	1	0.33848	1	0.48036	1	0.33104	1	0.16896	1	0.12559	1	0.42073	1	0.72613	1
SMTNL2	9 (4%)	239	NA	NA	NA	NA	0.049774	1	0.58865	1	0.60253	1	1	1	0.77603	1	1	1	0.91555	1	0.15804	1	0.78556	1	1	1
NFE2L2	15 (6%)	233	0.090516	1	0.83347	1	0.0033228	1	0.6327	1	0.2479	1	1	1	0.029118	1	0.0034733	1	0.47359	1	0.85032	1	0.33759	1	0.31349	1
CHD4	35 (14%)	213	0.098645	1	0.28356	1	0.62433	1	0.86307	1	0.96961	1	0.28657	1	0.63021	1	0.52357	1	0.36706	1	0.60735	1	0.77959	1	0.65943	1
RBMX	13 (5%)	235	0.1912	1	0.17985	1	0.14483	1	0.38511	1	0.01243	1	1	1	0.82189	1	0.022017	1	1	1	0.13216	1	0.67834	1	0.72613	1
FAM9A	14 (6%)	234	NA	NA	NA	NA	0.74995	1	0.26922	1	0.17795	1	0.022725	1	0.30901	1	0.17382	1	0.78373	1	0.10991	1	0.021755	1	0.070836	1
HPD	7 (3%)	241	NA	NA	NA	NA	0.41933	1	0.77601	1	0.44673	1	0.65085	1	0.37366	1	0.010289	1	0.43954	1	0.22102	1	0.81619	1	1	1
MORC4	20 (8%)	228	0.58319	1	0.17985	1	0.29961	1	0.27914	1	0.21229	1	0.033158	1	0.08349	1	0.30354	1	0.019135	1	0.28327	1	0.23312	1	0.87638	1
CASP8	17 (7%)	231	0.38127	1	0.059544	1	0.094625	1	0.6256	1	0.15421	1	0.26865	1	0.77654	1	0.26293	1	0.46809	1	0.023159	1	0.88463	1	0.68826	1
ABI1	4 (2%)	244	NA	NA	NA	NA	0.69866	1	NA	NA	0.64001	1	0.63688	1	0.55013	1	0.702	1	0.55701	1	0.60612	1	NA	NA	NA	NA
FOXA2	12 (5%)	236	NA	NA	NA	NA	0.90869	1	0.79654	1	0.071861	1	0.74395	1	0.81974	1	0.37053	1	0.19343	1	0.91592	1	0.46714	1	0.4748	1
BRS3	15 (6%)	233	0.53592	1	0.15102	1	0.25424	1	0.5184	1	0.3924	1	0.54035	1	0.057614	1	0.003046	1	0.30987	1	0.047767	1	0.54559	1	0.53259	1
NRAS	9 (4%)	239	NA	NA	NA	NA	0.5597	1	NA	NA	0.31592	1	1	1	0.8433	1	0.96568	1	0.58042	1	0.68026	1	NA	NA	NA	NA
DNER	18 (7%)	230	0.1912	1	0.051469	1	0.0031645	1	0.65463	1	0.021717	1	0.58145	1	0.6352	1	0.013014	1	0.66555	1	0.12809	1	0.67499	1	1	1
TIAL1	11 (4%)	237	0.38127	1	0.4049	1	0.2213	1	0.076575	1	0.56444	1	0.74395	1	0.13156	1	0.046886	1	0.73981	1	0.80898	1	0.8591	1	0.25043	1
RPL14	7 (3%)	241	NA	NA	NA	NA	0.80625	1	0.87459	1	0.47879	1	1	1	0.89951	1	0.59118	1	0.38526	1	0.90277	1	0.85097	1	1	1
SGK1	15 (6%)	233	0.38127	1	0.059544	1	0.25411	1	0.62581	1	0.22598	1	0.095402	1	0.84848	1	0.81086	1	0.29085	1	0.44557	1	0.67834	1	0.72613	1
SLC48A1	5 (2%)	243	NA	NA	NA	NA	0.59804	1	0.63943	1	0.80339	1	0.37153	1	0.62357	1	1	1	0.52559	1	0.59997	1	0.78556	1	0.69326	1
BCOR	30 (12%)	218	0.68711	1	0.4049	1	0.0015902	0.585	0.025079	1	0.51211	1	0.50027	1	0.10688	1	0.2402	1	0.90835	1	0.21342	1	0.59446	1	0.30206	1
ZNF263	8 (3%)	240	0.02425	1	0.059544	1	0.34501	1	0.38511	1	0.61054	1	1	1	0.28434	1	0.092854	1	0.15909	1	0.059785	1	0.42073	1	0.36691	1
RNF43	12 (5%)	236	0.13313	1	0.15102	1	0.35904	1	0.3781	1	0.29629	1	1	1	0.04293	1	2.6386e-05	0.0101	0.054572	1	0.016572	1	0.064321	1	0.057396	1