E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.012 0.1 -9999.0 0.0 -0.35 13.0 13.0 KLHL20 -0.008 0.074 0.174 1.0 -0.228 22.0 23.0 CYFIP2 0.014 0.067 -9999.0 0.0 -0.403 9.0 9.0 Rac1/GDP 0.002 0.075 -9999.0 0.0 -0.271 10.0 10.0 ENAH -0.018 0.1 -9999.0 0.0 -0.348 14.0 14.0 AP1M1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.025 0.001 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.023 0.023 -9999.0 0.0 -0.403 1.0 1.0 CDC42/GTP 0.018 0.035 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.021 0.045 -9999.0 0.0 -0.156 23.0 23.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.046 0.054 -9999.0 0.0 -0.216 12.0 12.0 RAPGEF1 -0.007 0.08 -9999.0 0.0 -0.336 8.0 8.0 CTNND1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.009 0.108 -9999.0 0.0 -0.291 42.0 42.0 CRK -0.008 0.083 -9999.0 0.0 -0.358 8.0 8.0 E-cadherin/gamma catenin/alpha catenin 0.039 0.048 -9999.0 0.0 -0.325 5.0 5.0 alphaE/beta7 Integrin 0.029 0.043 -9999.0 0.0 -0.285 6.0 6.0 IQGAP1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.048 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.01 0.097 -9999.0 0.0 -0.358 13.0 13.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.001 0.03 -9999.0 0.0 -0.202 3.0 3.0 MLLT4 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.039 0.041 -9999.0 0.0 -0.215 8.0 8.0 PI3K 0.002 0.039 -9999.0 0.0 -0.261 3.0 3.0 ARF6 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.027 0.051 -9999.0 0.0 -0.378 5.0 5.0 TIAM1 0.016 0.063 -9999.0 0.0 -0.403 8.0 8.0 E-cadherin(dimer)/Ca2+ 0.048 0.039 -9999.0 0.0 -0.203 6.0 6.0 AKT1 -0.009 0.025 0.099 1.0 -0.163 2.0 3.0 PIK3R1 0.003 0.091 -9999.0 0.0 -0.403 17.0 17.0 CDH1 0.017 0.05 -9999.0 0.0 -0.403 5.0 5.0 RhoA/GDP 0.004 0.073 -9999.0 0.0 -0.269 9.0 9.0 actin cytoskeleton organization -0.004 0.056 0.169 2.0 -0.169 20.0 22.0 CDC42/GDP 0.005 0.074 -9999.0 0.0 -0.266 11.0 11.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.012 0.039 -9999.0 0.0 -0.289 5.0 5.0 ITGB7 0.017 0.055 -9999.0 0.0 -0.403 6.0 6.0 RAC1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.052 0.042 -9999.0 0.0 -0.216 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.035 0.035 -9999.0 0.0 -0.2 6.0 6.0 mol:GDP -0.011 0.08 -9999.0 0.0 -0.307 11.0 11.0 CDC42/GTP/IQGAP1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.022 0.032 -9999.0 0.0 -0.403 2.0 2.0 p120 catenin/RhoA/GDP 0.011 0.076 -9999.0 0.0 -0.272 9.0 9.0 RAC1/GTP/IQGAP1 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.001 0.051 0.137 3.0 -0.166 18.0 21.0 NME1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.007 0.093 -9999.0 0.0 -0.287 33.0 33.0 regulation of cell-cell adhesion 0.011 0.03 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.001 0.031 -9999.0 0.0 -0.113 3.0 3.0 Rap1/GTP 0.022 0.044 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.055 0.061 -9999.0 0.0 -0.24 11.0 11.0 CCND1 -0.002 0.062 0.157 3.0 -0.206 18.0 21.0 VAV2 -0.037 0.185 -9999.0 0.0 -0.611 26.0 26.0 RAP1/GDP 0.019 0.065 0.206 1.0 -0.294 3.0 4.0 adherens junction assembly -0.006 0.091 -9999.0 0.0 -0.28 33.0 33.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.039 0.056 -9999.0 0.0 -0.228 12.0 12.0 E-cadherin/beta catenin 0.007 0.039 -9999.0 0.0 -0.288 6.0 6.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.014 0.102 -9999.0 0.0 -0.348 15.0 15.0 PIK3CA 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.027 0.11 -9999.0 0.0 -0.355 26.0 26.0 E-cadherin/beta catenin/alpha catenin 0.04 0.04 -9999.0 0.0 -0.237 6.0 6.0 ITGAE 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.01 0.109 -9999.0 0.0 -0.296 42.0 42.0