rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(4), ANAPC11(1), ANAPC2(1), ANAPC4(1), ANAPC5(1), ANAPC7(2), BTRC(2), CDC16(2), CDC20(1), CDC23(2), CDC27(3), CUL1(3), CUL2(1), CUL3(5), FBXW11(1), FBXW7(1), FZR1(4), SKP2(1), SMURF2(3), TCEB1(4), TCEB2(1), UBA1(1), UBE2D1(2), UBE2D3(1), UBE2E2(1), VHL(233), WWP2(2)	25294181	284	241	183	21	12	16	29	88	138	1	1.11e-07	<1.00e-15	<3.08e-13
2	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(1), ASPH(3), COPS5(1), EP300(6), HIF1A(3), JUN(2), NOS3(2), VHL(233)	10473682	251	228	153	15	10	11	29	71	129	1	1.12e-08	<1.00e-15	<3.08e-13
3	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(1), EIF1(1), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF2S2(1), EIF2S3(1), FLT1(4), FLT4(6), HIF1A(3), HRAS(1), KDR(5), NOS3(2), PIK3CA(12), PIK3R1(2), PTK2(1), SHC1(2), VHL(233)	21044758	280	238	179	21	15	20	30	81	133	1	1.78e-08	1.89e-15	3.88e-13
4	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(2), AKT2(3), AKT3(2), GRB2(1), ILK(1), MAPK3(1), PDK1(1), PIK3CA(12), PTEN(20), PTK2B(2), RBL2(2), SHC1(2), SOS1(6)	12480838	55	50	52	3	3	13	5	17	16	1	0.000257	8.50e-08	1.31e-05
5	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(2), AKT2(3), AKT3(2), CDKN1A(1), ELK1(1), GRB2(1), HRAS(1), NGFR(1), NTRK1(4), PIK3CA(12), SHC1(2), SOS1(6)	9746239	36	35	33	1	1	11	5	17	2	0	0.000274	1.70e-05	0.00209
6	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(1), ARPC1B(1), ARPC2(1), CDC42(1), PAK1(1), PDGFRA(7), PIK3CA(12), PIK3R1(2), RAC1(1), WASL(6)	8358184	33	32	30	2	0	9	3	17	4	0	0.00810	8.07e-05	0.00829
7	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(2), BCAR1(3), GRB2(1), ILK(1), ITGB1(3), MAPK3(1), PDK2(1), PIK3CA(12), PIK3R1(2), PTEN(20), PTK2(1), SHC1(2), SOS1(6)	11771993	55	50	52	6	3	11	4	19	17	1	0.0177	0.000129	0.0114
8	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(2), HLA-DRA(1), HLA-DRB1(12)	1276465	16	13	14	3	4	1	3	6	2	0	0.297	0.000216	0.0167
9	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	17	ABCB1(4), AKT1(2), ATM(15), CDKN1A(1), CSNK1A1(1), FHL2(1), HIF1A(3), IGFBP3(1), NFKBIB(1), TP53(10)	12308769	39	35	39	2	2	5	7	13	12	0	0.00367	0.00208	0.143
10	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(2), EIF4A2(3), EIF4E(1), EIF4G1(2), EIF4G2(3), EIF4G3(3), MKNK1(1), PDK2(1), PIK3CA(12), PIK3R1(2), PPP2CA(1), PTEN(20), RPS6KB1(1), TSC1(2), TSC2(5)	17176831	59	55	56	6	2	10	5	21	20	1	0.00631	0.00971	0.598
11	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(2), EIF2B5(1), EIF2S2(1), EIF2S3(1), EIF4E(1), INPPL1(2), PDK2(1), PIK3CA(12), PIK3R1(2), PPP2CA(1), PTEN(20), RPS6KB1(1)	12147172	45	43	42	5	1	9	2	13	19	1	0.0238	0.0119	0.664
12	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(1), AKT1(2), AKT2(3), AKT3(2), BTK(1), CDKN2A(5), GRB2(1), GSK3A(2), IARS(4), INPP5D(1), PDK1(1), PIK3CA(12), PPP1R13B(3), PTEN(20), RPS6KA1(2), RPS6KB1(1), SHC1(2), SOS1(6), SOS2(1), TEC(5), YWHAE(1)	22183202	76	67	73	9	4	15	6	27	23	1	0.00728	0.0133	0.669
13	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(2), MAX(3), MYC(1), SP3(1), TP53(10), WT1(3)	4260168	20	18	20	3	2	2	2	10	4	0	0.246	0.0147	0.669
14	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(2), HLA-DRA(1), HLA-DRB1(12), IL4(1)	2269336	17	14	15	4	4	1	4	6	2	0	0.387	0.0152	0.669
15	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	HLA-DRA(1), HLA-DRB1(12), IL3(1)	1672187	14	11	12	3	3	0	3	6	2	0	0.451	0.0166	0.682
16	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(1), CPS1(6), GLS(4), GOT1(3)	4816366	15	15	15	1	0	2	1	8	4	0	0.180	0.0218	0.805
17	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(2), GOT1(3), GOT2(2), TYR(3)	2929848	10	10	10	1	0	0	3	2	5	0	0.444	0.0222	0.805
18	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(7), PDXK(1), PDXP(1), PSAT1(1)	2946049	10	10	10	0	1	1	0	6	2	0	0.144	0.0240	0.821
19	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	48	AKT1(2), AKT2(3), AKT3(2), BRD4(6), CAP1(1), CBL(1), CDC42(1), CDKN2A(5), F2RL2(1), GRB2(1), GSK3A(2), INPPL1(2), IRS1(3), IRS4(1), LNPEP(3), MAPK3(1), PARD3(2), PARD6A(2), PDK1(1), PIK3CA(12), PIK3R1(2), PPYR1(2), PTEN(20), PTPN1(1), RPS6KA1(2), RPS6KB1(1), SHC1(2), SLC2A4(1), SORBS1(1), SOS1(6), SOS2(1), YWHAE(1)	35289010	92	84	87	8	8	15	10	31	27	1	0.000214	0.0302	0.978
20	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(3), CD28(1), CD3E(2), CD3G(1), CD4(2)	2024848	9	7	8	0	1	2	1	5	0	0	0.0704	0.0344	0.987
21	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(4), CDKN2A(5), E2F1(1), MYC(1), PIK3CA(12), PIK3R1(2), POLR1A(3), POLR1B(2), POLR1C(3), RAC1(1), RB1(1), TP53(10)	12131686	45	41	41	5	4	12	4	18	7	0	0.00904	0.0364	0.987
22	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(2), CHUK(1), GHR(1), NFKB1(1), PIK3CA(12), PIK3R1(2), PPP2CA(1), RELA(1)	8733545	21	21	18	0	0	9	2	7	3	0	0.00147	0.0365	0.987
23	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(5), EGF(4), EGFR(7), HGS(2), RAB5A(1)	7898260	19	19	18	0	3	1	5	5	5	0	0.0101	0.0375	0.987
24	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNGR1(2), IFNGR2(1), JAK1(4), JAK2(5), STAT1(4)	5136758	16	16	16	2	1	0	1	10	4	0	0.398	0.0384	0.987
25	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(4), CTH(1), GOT1(3), GOT2(2), LDHB(1), LDHC(1), MPST(2)	4180017	14	14	14	2	1	0	2	6	5	0	0.471	0.0460	1.000
26	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(1), GBA3(2), MPO(4), PRDX1(1), PRDX5(1), TPO(3), TYR(3)	5954630	15	15	15	1	1	2	5	5	2	0	0.0766	0.0500	1.000
27	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(4), EGFR(7), ERBB3(3), NRG1(4), UBE2D1(2)	6368227	20	20	19	3	2	1	4	8	5	0	0.241	0.0679	1.000
28	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(1), DNAJC3(2), EIF2S2(1), MAP3K14(1), NFKB1(1), RELA(1), TP53(10)	6262124	17	16	17	2	2	5	2	4	4	0	0.135	0.0695	1.000
29	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CD4(2), HLA-DRA(1), HLA-DRB1(12), IL4(1)	3130229	16	13	14	4	3	1	4	6	2	0	0.484	0.0818	1.000
30	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(2), GGT1(2), SHMT1(2), SHMT2(3)	2522169	9	9	9	2	0	1	3	2	3	0	0.523	0.0869	1.000
31	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(3), GOT2(2)	1638319	5	5	5	1	0	0	2	0	3	0	0.685	0.103	1.000
32	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(4), FUT1(1), GCNT2(4), ST8SIA1(2)	3625939	11	11	9	2	1	1	1	3	5	0	0.593	0.105	1.000
33	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(7), CD38(1), ENPP3(1), NMNAT2(1), NNMT(1), NNT(6), NT5M(2), QPRT(1)	8974205	20	20	20	1	0	3	3	12	2	0	0.0354	0.130	1.000
34	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(3), CYP2E1(1), NR1I3(1), PTGS1(1), PTGS2(4)	3264531	10	10	10	2	1	1	1	4	3	0	0.529	0.130	1.000
35	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AASDH(3), AASDHPPT(2), AASS(4), KARS(1)	4362596	10	10	10	1	0	2	0	3	5	0	0.418	0.156	1.000
36	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3E(2), CD3G(1)	724975	3	2	3	0	0	1	1	1	0	0	0.376	0.166	1.000
37	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(1), GNAS(4), GNB1(2), PPP2CA(1), PRKACB(4), PRKACG(2), PRKAG1(1), PRKAG2(4), PRKAR1A(2), PRKAR2B(1)	9330868	22	22	22	2	2	2	1	14	3	0	0.126	0.170	1.000
38	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AASDHPPT(2), AASS(4), KARS(1)	2965715	7	7	7	1	0	1	0	2	4	0	0.574	0.173	1.000
39	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ5(2), COQ6(2), NDUFA13(2)	2543806	6	6	6	0	2	1	0	2	1	0	0.182	0.186	1.000
40	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(4), FUT1(1), FUT6(3), ST3GAL3(1)	2904083	9	9	6	2	2	0	0	0	7	0	0.905	0.196	1.000
41	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), FPGS(2)	3715075	12	11	12	2	1	3	1	6	1	0	0.241	0.199	1.000
42	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(5), PRKACB(4), PRKACG(2), PRKAG1(1), PRKAR2B(1)	6208875	13	13	13	1	2	2	2	7	0	0	0.107	0.206	1.000
43	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREM(1), JUN(2), MAPK3(1), POLR2A(6), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1)	7845704	19	18	19	2	4	2	2	9	2	0	0.0923	0.207	1.000
44	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3E(2), CD3G(1), IL2RA(2), IL4(1), TGFB2(2), TGFB3(1), TGFBR2(1), TGFBR3(1), TOB1(2), TOB2(3)	6625463	17	16	17	2	1	3	4	7	2	0	0.167	0.212	1.000
45	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD3E(2), CD3G(1), CD86(1), GRB2(1), HLA-DRA(1), HLA-DRB1(12), ITK(1), PIK3CA(12), PIK3R1(2), PTPN11(1)	7740259	35	30	30	6	4	9	6	12	4	0	0.103	0.233	1.000
46	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(1), CDC25A(1), CDC25C(2), SHH(1), XPO1(6)	5348304	11	11	11	1	0	0	4	6	1	0	0.206	0.244	1.000
47	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GALNS(2), GLB1(4), GNS(1), GUSB(6), HEXA(3), IDS(2), IDUA(1), LCT(2)	8830693	22	18	20	2	4	2	4	10	2	0	0.0329	0.248	1.000
48	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(5), AOC2(3), AOC3(1), CES1(2)	3505264	11	10	11	2	0	2	2	6	1	0	0.360	0.250	1.000
49	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(2), EHHADH(3), HADHA(1)	3042194	6	6	6	0	1	2	1	1	1	0	0.153	0.258	1.000
50	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(1), CSF1R(5), EGF(4), EGFR(7), GRB2(1), MET(3), PDGFRA(7), SH3GLB1(1), SH3GLB2(1), SH3KBP1(3), SRC(2)	12092696	35	33	33	5	1	6	4	16	8	0	0.124	0.269	1.000
51	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD34(1), CD3E(2), CD3G(1), CD4(2), IL3(1), KITLG(2)	3881708	9	8	9	1	0	2	1	5	1	0	0.349	0.271	1.000
52	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(2), EHHADH(3), HADH(1), HADHA(1), HSD17B4(1), SIRT1(4), SIRT5(1), SIRT7(1)	7386124	14	13	14	1	2	4	3	2	3	0	0.0801	0.273	1.000
53	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADM(1), ACADS(2), ECHS1(2), HADHA(1)	3351862	6	6	5	0	3	0	2	1	0	0	0.105	0.277	1.000
54	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	ARHGAP5(9), ARHGDIB(1), CASP1(1), CASP10(3), JUN(2), PRF1(1)	7740063	17	15	15	2	0	4	2	7	3	1	0.188	0.282	1.000
55	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(1)	450414	1	1	1	0	0	0	1	0	0	0	0.751	0.285	1.000
56	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(1), HBXIP(1), HRAS(1), PTK2B(2), SHC1(2), SOS1(6), SRC(2)	5343368	15	15	15	3	1	6	2	6	0	0	0.277	0.287	1.000
57	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3E(2), CD3G(1), CD4(2), FYN(1), HLA-DRA(1), HLA-DRB1(12), PTPRC(6)	5358108	25	20	23	5	3	2	4	13	3	0	0.348	0.291	1.000
58	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(1), ARG1(1), GLS(4), PRODH(1)	3471066	7	7	7	1	0	1	2	3	1	0	0.433	0.301	1.000
59	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(4), GLS2(2)	2752495	6	6	6	0	0	1	0	5	0	0	0.272	0.305	1.000
60	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(4), B3GNT2(2), B3GNT3(1), B3GNT5(1), B4GALT3(1), B4GALT4(2), FUT1(1), FUT6(3), GCNT2(4), ST3GAL6(1), ST8SIA1(2)	9346872	22	21	19	3	2	3	3	5	9	0	0.291	0.320	1.000
61	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(12), MAP2(2), PPP2CA(1), PRKACB(4), PRKACG(2), PRKAG1(1), PRKAR2B(1), PRKCE(4)	11238170	27	25	26	3	4	1	0	15	7	0	0.232	0.321	1.000
62	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GALNS(2), GLB1(4), GNS(1), GUSB(6), HEXA(3), HGSNAT(1), HPSE(2), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(2), SPAM1(4)	12652402	34	27	32	4	6	5	5	15	3	0	0.0155	0.322	1.000
63	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(2), ENO2(1), GOT1(3), GOT2(2), PAH(3), YARS(1)	5167192	12	12	12	2	0	0	4	4	4	0	0.457	0.324	1.000
64	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	DRD1(1), DRD2(1), GRM1(4), PLCB1(1), PPP1R1B(1), PPP2CA(1), PPP3CA(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1)	9796405	19	19	19	1	3	0	0	12	4	0	0.0483	0.333	1.000
65	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CD3E(2), CD3G(1), CD4(2), CREBBP(4), CSK(2), GNAS(4), GNB1(2), HLA-DRA(1), HLA-DRB1(12), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PTPRC(6)	13758110	46	36	44	6	5	5	5	27	4	0	0.0545	0.335	1.000
66	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(1), CD3E(2), CD3G(1), CD4(2), CREBBP(4), CSK(2), GNAS(4), GNB1(2), HLA-DRA(1), HLA-DRB1(12), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PTPRC(6)	13758110	46	36	44	6	5	5	5	27	4	0	0.0545	0.335	1.000
67	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(4), EGFR(7), MAP3K1(5), MAPK14(1), NCOR2(4), RARA(4), THRA(2)	10677896	27	27	26	4	1	3	7	9	7	0	0.138	0.340	1.000
68	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(3), STX1A(1)	1996435	4	4	4	1	0	0	0	2	2	0	0.856	0.348	1.000
69	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(2), EPHX2(1), RDH11(3)	2927708	6	6	6	1	1	0	1	4	0	0	0.463	0.352	1.000
70	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(1), CHUK(1), IL4(1), JUN(2), MAP3K1(5), MAP3K5(5), MAP4K5(4), MAPK14(1), NFKB1(1), RELA(1), TNFRSF9(1), TNFSF9(1)	12202915	24	23	24	2	0	3	1	14	6	0	0.151	0.361	1.000
71	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	NRF1(1), UBE2A(2), UBE2D1(2), UBE2D3(1), UBE2H(2), UBE2J1(1), UBE2J2(1), UBE2N(1), UBE3A(1)	6501222	12	12	12	1	1	1	1	5	4	0	0.250	0.363	1.000
72	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(1), ADRB2(2), GNAS(4), PLCE1(3), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RAP2B(2)	8918662	21	21	21	3	2	1	2	11	5	0	0.363	0.366	1.000
73	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(2), GRB2(1), IL4(1), IL4R(2), IRS1(3), JAK1(4), JAK3(4), RPS6KB1(1), SHC1(2), STAT6(4)	8845567	24	24	23	4	3	3	2	9	7	0	0.271	0.369	1.000
74	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(2), CDC42(1), CHUK(1), ELK1(1), HRAS(1), MAPK3(1), NFKB1(1), PIK3CA(12), PIK3R1(2), RAC1(1), RALBP1(1), RELA(1)	11917286	25	25	22	3	1	10	2	9	3	0	0.0590	0.388	1.000
75	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	DCN(3), FMOD(2), LUM(1)	2235482	6	6	6	2	0	1	0	4	1	0	0.681	0.389	1.000
76	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(2), EIF4A2(3), EIF4E(1), EIF4G1(2), EIF4G2(3), EIF4G3(3), GHR(1), IRS1(3), MAPK14(1), MAPK3(1), MKNK1(1), PABPC1(20), PDK2(1), PIK3CA(12), PIK3R1(2), PTEN(20), RPS6KB1(1)	17233400	77	71	68	13	5	16	6	27	22	1	0.0545	0.396	1.000
77	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), CAT(2), EPX(1), MPO(4), PRDX1(1), PRDX5(1), SHMT1(2), SHMT2(3), TPO(3)	7260897	18	18	18	3	1	3	4	7	3	0	0.240	0.397	1.000
78	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	PGLYRP2(2)	1069531	2	2	2	0	0	1	0	1	0	0	0.498	0.408	1.000
79	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(1), AKT1(2), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), GNAS(4), GRB2(1), HRAS(1), MAPK14(1), MAPK3(1), PIK3CA(12), PIK3R1(2), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RAC1(1), RPS6KA1(2), SOS1(6)	17831564	48	47	45	7	4	10	4	27	3	0	0.0559	0.427	1.000
80	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(4), DAXX(4), HRAS(1), PAX3(1), PML(3), RARA(4), RB1(1), SIRT1(4), SP100(1), TNFRSF1A(1), TP53(10)	11424579	34	31	34	5	3	5	7	15	4	0	0.0744	0.436	1.000
81	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(1), MMP14(1), MMP2(4), MMP9(1), RECK(1)	4647674	8	8	8	1	0	2	1	3	2	0	0.375	0.438	1.000
82	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNGR1(2), JAK1(4), JAK2(5), PTPRU(4), STAT1(4)	7072431	19	17	19	3	1	0	1	13	4	0	0.445	0.443	1.000
83	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(15), ATR(5), CDC25C(2), CHEK2(3), TP53(10)	9985565	35	30	34	5	2	3	7	13	10	0	0.160	0.461	1.000
84	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(2), BCR(1), GRB2(1), HRAS(1), JAK2(5), JUN(2), MAP3K1(5), MAPK3(1), MYC(1), PIK3CA(12), PIK3R1(2), SOS1(6), STAT1(4), STAT5B(1)	16989027	44	42	41	6	2	9	4	25	4	0	0.0418	0.464	1.000
85	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDOA(2), ALDOB(3), TPI1(1)	2389282	6	6	6	4	0	0	1	1	4	0	0.993	0.471	1.000
86	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTR2(1), ARPC1B(1), ARPC2(1), CDC42(1), RAC1(1), WASL(6)	5054098	11	11	11	2	0	3	0	8	0	0	0.439	0.473	1.000
87	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(2), APC(6), AXIN1(2), CTNNB1(1), DVL1(1), FZD1(2), GJA1(2), GNAI1(1), IRAK1(3), LBP(1), LEF1(1), LY96(1), NFKB1(1), PIK3CA(12), PIK3R1(2), PPP2CA(1), RELA(1), TLR4(2)	18561496	42	42	38	5	2	12	6	16	6	0	0.00712	0.475	1.000
88	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), CD3E(2), CD3G(1), CD4(2), ITGAL(4), ITGB2(1), PTPRC(6)	6984514	17	15	17	3	2	3	2	9	1	0	0.253	0.475	1.000
89	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ECHS1(2), EHHADH(3), HADHA(1), HADHB(2)	5239709	8	8	8	0	1	3	2	1	1	0	0.0751	0.477	1.000
90	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), CAT(2), EPX(1), MPO(4), MTHFR(1), SHMT1(2), SHMT2(3), TPO(3)	7138474	17	17	17	3	1	3	3	7	3	0	0.287	0.477	1.000
91	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(1), GNAS(4), GNB1(2), PRKACA(1), PRKAR1A(2)	3885215	10	10	10	2	0	1	0	8	1	0	0.676	0.479	1.000
92	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), MST1(1), MST1R(4)	3737496	6	6	5	1	0	0	4	1	1	0	0.523	0.495	1.000
93	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALE(1), GALT(2), UGP2(1), UXS1(1)	3135576	5	5	5	1	0	0	3	2	0	0	0.562	0.513	1.000
94	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(1), CAMK1(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CAMKK1(1), CAMKK2(2), SYT1(1)	7152685	12	12	12	0	1	1	1	7	2	0	0.0891	0.514	1.000
95	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALE(1), GALT(2), UXS1(1)	2482167	4	4	4	1	0	0	2	2	0	0	0.701	0.516	1.000
96	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	GNAS(4), GNB1(2), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1)	5851185	15	15	15	3	2	1	0	11	1	0	0.564	0.524	1.000
97	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CREBBP(4), EP300(6), NCOA3(5), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RARA(4)	12711401	28	28	28	4	2	1	7	17	1	0	0.0971	0.529	1.000
98	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(2), BMPR1B(1), BMPR2(4)	3811083	7	6	7	0	0	0	1	4	2	0	0.162	0.533	1.000
99	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(11), RANGAP1(1)	5254489	13	10	13	2	1	5	2	5	0	0	0.224	0.536	1.000
100	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	BHMT(1), CTH(1), DNMT1(6), DNMT3A(5), DNMT3B(1), MARS(2), MARS2(3)	10707151	19	19	19	2	2	2	5	6	4	0	0.114	0.538	1.000
101	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CR1(7), CR2(1), HLA-DRA(1), HLA-DRB1(12), ITGAL(4), ITGB2(1), PTPRC(6)	9271803	32	28	30	6	5	1	4	17	5	0	0.282	0.541	1.000
102	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	25	AKT1(2), AKT2(3), AKT3(2), GRB2(1), GSK3A(2), IL4R(2), IRS1(3), JAK1(4), JAK3(4), MAP4K1(1), MAPK3(1), PDK1(1), PIK3CA(12), PIK3R1(2), PPP1R13B(3), SHC1(2), SOS1(6), SOS2(1), STAT6(4)	21627513	56	53	52	8	4	13	6	23	10	0	0.0252	0.552	1.000
103	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ECHS1(2), EHHADH(3), HADHA(1), SDHB(1)	4874713	7	7	7	0	1	2	2	1	1	0	0.110	0.554	1.000
104	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG3(2), ATG7(3), BECN1(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), PIK3C3(1), PIK3R4(3), ULK1(1), ULK2(1), ULK3(3)	13185203	23	23	23	2	1	3	1	13	5	0	0.120	0.567	1.000
105	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(2), HLA-DRA(1), HLA-DRB1(12), IFNA1(2), IFNB1(2), IL15(1), IL3(1), IL4(1), LTA(1), TGFB2(2), TGFB3(1)	7932143	26	23	24	5	3	5	4	12	2	0	0.176	0.575	1.000
106	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	4	FOSB(1), GRIA2(3), PPP1R1B(1)	2194172	5	5	5	2	1	1	0	3	0	0	0.747	0.579	1.000
107	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(2), AKT1(2), CALM2(1), GNAS(4), GNB1(2), NFKB1(1), NOS3(2), NPPA(1), PIK3CA(12), PIK3R1(2), RELA(1), SYT1(1)	10975684	31	31	28	5	1	11	3	13	3	0	0.117	0.585	1.000
108	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(2), MAP2K3(9), MAP2K6(1), MAP3K1(5), MAPK14(1), MAPK3(1), NFKB1(1), PIK3CA(12), PIK3R1(2), RB1(1), RELA(1)	12208236	36	35	29	6	5	10	2	16	3	0	0.0815	0.595	1.000
109	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(2), GRB2(1), HRAS(1), MAPK3(1), MEF2A(2), MEF2D(1), NTRK1(4), PIK3CA(12), PIK3R1(2), RPS6KA1(2), SHC1(2)	11780934	30	30	27	5	4	8	4	11	3	0	0.0830	0.600	1.000
110	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	CTH(1), GGT1(2), MARS(2), MARS2(3), PAPSS1(3), PAPSS2(2), SEPHS1(1)	7505152	14	14	14	2	2	0	4	5	3	0	0.240	0.607	1.000
111	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTR2(1), ARPC1B(1), ARPC2(1), NCKAP1(1), NTRK1(4), RAC1(1), WASF2(1), WASF3(1), WASL(6)	9435096	17	17	17	2	0	3	1	12	1	0	0.229	0.612	1.000
112	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), HPRT1(1), IMPDH1(1), POLB(1), POLD1(3), POLG(2), PRPS2(2), RRM1(2)	7707287	13	13	13	2	2	3	1	5	2	0	0.215	0.614	1.000
113	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(1), CNR2(1), DNMT1(6), MTNR1B(1), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(2), PTGIR(1), TBXA2R(1)	6477318	17	17	17	4	1	2	4	7	3	0	0.473	0.616	1.000
114	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(1), CSAD(1), GAD2(1), GGT1(2)	3484980	5	5	5	1	0	1	2	1	1	0	0.469	0.627	1.000
115	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ECHS1(2), HADH(1), HADHA(1), HADHB(2), HSD17B4(1), MECR(1)	5191321	8	7	8	0	1	1	4	2	0	0	0.0635	0.627	1.000
116	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	BHMT(1), CTH(1), DNMT1(6), DNMT3A(5), DNMT3B(1), MARS(2), MARS2(3), MTAP(2)	12789093	21	21	21	2	2	2	6	7	4	0	0.0802	0.630	1.000
117	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(2), GLI2(4), GLI3(3), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), SHH(1), SMO(3)	9620228	22	21	22	4	4	1	2	13	2	0	0.291	0.631	1.000
118	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(1), HLA-DRA(1), HLA-DRB1(12), IFNGR1(2), IFNGR2(1), IL12RB1(1), IL12RB2(2), IL18R1(1), IL2RA(2), IL4(1), IL4R(2)	7709460	27	23	25	6	6	1	4	13	3	0	0.327	0.637	1.000
119	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(4), B3GALT2(2), B3GNT5(1), FUT1(1), ST3GAL3(1)	4324396	9	9	7	3	1	0	1	1	6	0	0.933	0.637	1.000
120	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(1), CREM(1), FHL5(2), GNAS(4), XPO1(6)	5753041	14	14	14	3	2	1	3	7	1	0	0.521	0.638	1.000
121	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(1), GBA(2), GBA3(2), MPO(4), TPO(3)	5150129	12	12	12	3	1	2	4	5	0	0	0.390	0.640	1.000
122	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(4), CARS2(2), CTH(1), GOT1(3), GOT2(2), LDHAL6B(1), LDHB(1), LDHC(1), MPST(2), SULT1B1(1), SULT4A1(1)	7728778	19	19	19	4	1	0	2	9	7	0	0.707	0.645	1.000
123	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDK(1), CTH(1), MUT(2)	3013227	4	4	4	0	1	0	1	0	2	0	0.467	0.645	1.000
124	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD28(1), CD3E(2), CD3G(1), ITGAL(4), ITGB2(1), PTPRC(6)	6594819	15	13	15	3	2	2	2	8	1	0	0.356	0.646	1.000
125	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARSA(1), GOT1(3), GOT2(2), PAH(3), YARS(1)	5406809	10	10	10	2	0	0	3	3	4	0	0.568	0.654	1.000
126	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), CDKN1A(1), GRIN1(2), HIF1A(3), JAK2(5), NFKB1(1), RELA(1)	7829958	14	13	14	2	0	4	1	6	3	0	0.238	0.669	1.000
127	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(4), LARS(3), LARS2(1), PDHA1(1), PDHA2(1), PDHB(1)	6247357	12	11	11	2	0	2	1	5	4	0	0.456	0.672	1.000
128	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(1), IDI1(1), IDI2(2)	2721446	4	4	4	1	0	0	0	3	1	0	0.831	0.676	1.000
129	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(1)	1038575	1	1	1	0	0	0	0	1	0	0	0.838	0.678	1.000
130	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(1), MTMR2(1), NFS1(2), TPK1(1)	4001753	5	5	5	0	2	0	0	3	0	0	0.310	0.685	1.000
131	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2)	3513076	6	6	5	2	1	0	0	3	2	0	0.896	0.694	1.000
132	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(4), CPT1A(1), LEP(1), LEPR(1), PRKAG1(1), PRKAG2(4)	9049850	12	12	12	1	0	3	3	3	3	0	0.0937	0.696	1.000
133	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(3), GABBR1(1), GPRC5A(1), GPRC5B(1), GPRC5C(1), GRM1(4), GRM2(2), GRM3(2), GRM4(3), GRM5(4), GRM7(1), GRM8(2)	11996305	25	25	25	4	4	5	1	13	2	0	0.125	0.700	1.000
134	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(1)	953417	1	1	1	1	0	0	0	1	0	0	0.943	0.713	1.000
135	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3E(2), CD3G(1), HLA-A(4), ITGAL(4), ITGB2(1), PRF1(1)	5137727	15	12	15	4	1	5	2	5	2	0	0.383	0.714	1.000
136	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(4), ABCB11(1), ABCB4(1), ABCC1(2), ABCC3(7)	9082866	15	15	15	2	1	1	4	7	2	0	0.227	0.718	1.000
137	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(3), POLR1B(2), POLR1C(3), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLR3A(4), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1)	14511885	32	30	29	4	0	8	3	15	6	0	0.0483	0.722	1.000
138	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(1), GSS(1), NFKB1(1), NOX1(2), RELA(1), XDH(2)	6077631	8	8	8	1	0	2	2	4	0	0	0.251	0.723	1.000
139	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MAPKAPK5(1), NFKB1(1), NFKBIB(1), NFKBIL1(1), PIK3CA(12), PIK3R1(2), SYT1(1), TRAF3(1), TRAF5(3), TRAF6(1)	20255215	36	34	33	3	4	9	3	16	4	0	0.00313	0.727	1.000
140	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	RAB1A(1), RAB3A(1), RAB5A(1)	2650758	3	3	3	0	1	0	1	0	1	0	0.378	0.730	1.000
141	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(1), FLT3(2), IL3(1), KITLG(2), TGFB2(2), TGFB3(1)	5170275	9	9	9	2	0	1	1	6	1	0	0.663	0.732	1.000
142	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	16	ADAM10(4), ANKRD1(1), EIF4E(1), IFRD1(1), IL1R1(1), NR4A3(2), WDR1(1)	6617914	11	11	11	2	0	3	2	3	3	0	0.443	0.735	1.000
143	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(1), CCR5(3), CD28(1), CD4(2), CXCR4(1), IFNGR1(2), IFNGR2(1), IL12RB1(1), IL12RB2(2), IL18R1(1), IL4(1), IL4R(2), TGFB2(2), TGFB3(1)	12475000	21	19	20	2	3	2	2	13	1	0	0.0670	0.742	1.000
144	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(7), CD38(1), ENPP3(1), NMNAT2(1), NMNAT3(2), NNMT(1), NNT(6), NT5C1B(1), NT5C2(1), NT5C3(1), NT5M(2), NUDT12(1), QPRT(1)	13268381	26	25	26	4	0	3	4	14	5	0	0.234	0.743	1.000
145	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	ATM(15), CCNE1(2), CDK2(2), CDK4(1), CDKN1A(1), E2F1(1), PCNA(3), RB1(1), TP53(10)	11322059	36	27	36	6	3	5	6	12	10	0	0.162	0.746	1.000
146	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(1), F13B(2), HSD17B1(1), HSD17B4(1), HSD3B1(1)	5022413	6	6	6	1	1	0	3	2	0	0	0.435	0.756	1.000
147	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA3(2), PSMA4(2), PSMA6(3), PSMB4(1), PSMB5(1), PSMB7(1), RPN1(2), RPN2(1), UBE2A(2), UBE3A(1)	8192549	16	16	16	3	0	1	2	8	5	0	0.536	0.759	1.000
148	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(1), ABP1(5), AOC2(3), AOC3(1), CES1(2), DDHD1(2), ESCO1(2), ESCO2(1), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1)	15496342	28	25	28	2	1	3	4	15	5	0	0.0494	0.761	1.000
149	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	ALAS1(4), ALAS2(3), CPO(1), FECH(2), GATA1(1), HBB(3)	5009016	14	14	12	4	0	1	2	9	2	0	0.642	0.770	1.000
150	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(1), ESCO1(2), ESCO2(1), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1)	10184606	15	14	15	1	1	1	3	8	2	0	0.131	0.772	1.000
151	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(6), C5(4), C7(2)	7970191	12	12	12	2	1	2	1	6	2	0	0.330	0.773	1.000
152	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(2), GBA3(2), GGT1(2), SHMT1(2), SHMT2(3)	3431600	11	11	11	4	0	1	3	4	3	0	0.757	0.777	1.000
153	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(2), HTR2C(1), PLCB1(1), TUB(2)	4389203	6	6	6	1	0	0	0	5	1	0	0.622	0.779	1.000
154	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CFL1(1), CFLAR(1)	2379318	2	2	2	1	0	0	1	0	1	0	0.893	0.785	1.000
155	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(1), CLOCK(1), PER1(4)	5237843	6	6	6	1	0	0	2	3	0	1	0.422	0.786	1.000
156	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	HGD(1)	1401723	1	1	1	1	0	0	1	0	0	0	0.902	0.786	1.000
157	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(1), HDAC9(2), MEF2A(2), MEF2D(1)	5073214	6	6	6	0	1	0	1	2	2	0	0.326	0.787	1.000
158	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(6), RPE(1), UCHL3(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2)	10943629	21	17	19	3	1	5	4	5	6	0	0.171	0.791	1.000
159	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGEF2(5), COPA(4), GBF1(6), GPLD1(1), KDELR2(2), KDELR3(2)	10108847	21	20	21	4	0	1	4	11	4	1	0.455	0.795	1.000
160	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(2), CHRNB1(1), PIK3CA(12), PIK3R1(2), PTK2(1), PTK2B(2), SRC(2), TERT(4)	10201486	26	26	23	5	2	12	2	8	2	0	0.115	0.802	1.000
161	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(4), CCNE1(2), CDK2(2), CUL1(3), E2F1(1), RB1(1), SKP2(1)	5427994	14	13	14	4	1	3	2	3	5	0	0.602	0.803	1.000
162	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(1), CAMK1(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), ESRRA(2), MEF2A(2), MEF2D(1), PPP3CA(1), PPP3CC(1), SLC2A4(1), SYT1(1)	12743303	17	17	16	1	2	1	2	7	5	0	0.133	0.808	1.000
163	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CYP11A1(1), CYP11B2(2), CYP17A1(1), HSD3B1(1)	4223555	5	5	5	0	0	0	1	4	0	0	0.364	0.811	1.000
164	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(5), AGXT(1), AGXT2(1), AKR1B10(2), ALAS1(4), ALAS2(3), AOC2(3), AOC3(1), BHMT(1), CHDH(2), CHKB(1), CTH(1), DAO(1), DLD(2), DMGDH(4), GATM(2), GLDC(1), GNMT(2), MAOA(1), PHGDH(2), PIPOX(1), PISD(1), PSAT1(1), RDH11(3), SARDH(2), SARS(3), SHMT1(2), SHMT2(3), TARS(2), TARS2(3)	26493557	61	57	60	8	5	10	13	27	6	0	0.00495	0.817	1.000
165	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(1), CDC42(1), DAXX(4), ELK1(1), GRB2(1), HRAS(1), HSPB2(1), MAP2K6(1), MAP3K1(5), MAP3K5(5), MAP3K7(1), MAP3K9(1), MAPK14(1), MAPKAPK2(2), MAPKAPK5(1), MAX(3), MEF2A(2), MEF2D(1), MKNK1(1), MYC(1), PLA2G4A(1), RAC1(1), RIPK1(1), SHC1(2), STAT1(4), TGFB2(2), TGFB3(1), TRADD(1)	22702665	48	46	47	6	4	3	3	28	10	0	0.0778	0.820	1.000
166	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(1), CDKN1A(1), NEK1(2), WEE1(1)	4601050	5	5	5	1	0	1	0	3	1	0	0.707	0.827	1.000
167	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(3), AP2A1(1), BIN1(3), CALM2(1), DNM1(1), EPN1(1), EPS15(2), PICALM(1), PPP3CA(1), PPP3CC(1), SYNJ1(4), SYNJ2(5), SYT1(1)	13786023	25	25	23	4	1	5	1	15	3	0	0.223	0.834	1.000
168	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B2(2), CYP17A1(1), CYP21A2(2), HSD3B1(1)	5740192	7	7	7	0	0	0	1	5	1	0	0.303	0.844	1.000
169	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	CYP11A1(1), CYP11B2(2), CYP17A1(1), CYP21A2(2), HSD3B1(1)	5740192	7	7	7	0	0	0	1	5	1	0	0.303	0.844	1.000
170	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	FYN(1), JUN(2), MAPK14(1), THBS1(6)	4457452	10	10	10	3	0	0	2	7	1	0	0.790	0.850	1.000
171	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(1), IDI1(1)	2048015	2	2	2	1	0	0	0	1	1	0	0.951	0.850	1.000
172	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(2), DHRS2(1), PON3(2), RDH11(3)	5499382	8	8	8	2	1	0	3	4	0	0	0.550	0.853	1.000
173	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(3), ENO1(2), HK1(4), PFKL(1), PGAM1(1), PGK1(2), TPI1(1)	5618781	14	12	14	4	2	2	2	4	4	0	0.551	0.853	1.000
174	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACOX1(1), ACOX3(2), ELOVL2(1), ELOVL5(1), FADS2(2), FASN(3), HADHA(1), PECR(1)	8764661	12	11	12	2	3	1	3	5	0	0	0.205	0.854	1.000
175	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(1), CHIA(2), CHIT1(6), CTBS(1), CYB5R1(2), CYB5R3(2), GFPT1(1), GFPT2(1), GNPDA1(1), HEXA(3), HK1(4), MTMR1(1), MTMR2(1), NAGK(2), NANS(2), NPL(1), RENBP(2)	17800239	33	31	32	4	5	3	5	13	7	0	0.0622	0.854	1.000
176	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(1), EXT2(1), EXTL1(1), EXTL3(2), GLCE(2), HS2ST1(1), HS3ST5(1), NDST1(2), NDST2(2), NDST4(3)	12515265	16	16	16	1	2	3	5	6	0	0	0.0312	0.861	1.000
177	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(4), IDH1(2), MDH1(1), SDHB(1)	5550156	8	8	8	2	1	0	1	5	1	0	0.570	0.862	1.000
178	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	ELK1(1), GRB2(1), HRAS(1), INSR(3), IRS1(3), JUN(2), MAPK3(1), PIK3CA(12), PIK3R1(2), PTPN11(1), RASA1(3), SHC1(2), SLC2A4(1), SOS1(6), SRF(1)	15351307	40	38	37	8	3	14	5	16	2	0	0.0831	0.864	1.000
179	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(1), AKT1(2), AKT2(3), AKT3(2), ARHGAP1(1), ARHGEF11(3), BTK(1), CDC42(1), CFL1(1), INPPL1(2), ITPR1(2), ITPR2(8), ITPR3(3), MYLK(4), MYLK2(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PDK1(1), PIK3CA(12), PIK3CG(3), PIK3R1(2), PITX2(1), PPP1R13B(3), PTEN(20), RACGAP1(1), RHO(1), ROCK1(4), ROCK2(3), SAG(2), WASL(6)	43511786	102	85	99	11	4	24	10	37	26	1	0.000101	0.868	1.000
180	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(1)	1256994	1	1	1	1	0	0	0	1	0	0	0.940	0.874	1.000
181	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(6), CDH1(2), CREBBP(4), EP300(6), MAP3K7(1), MAPK3(1), SKIL(1), TGFB2(2), TGFB3(1), TGFBR2(1)	15938463	25	25	25	3	1	3	7	13	1	0	0.0575	0.875	1.000
182	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	DHRS2(1), ECHS1(2), EHHADH(3), ESCO1(2), ESCO2(1), FN3K(1), HADHA(1), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1), YOD1(1)	15997725	23	22	23	2	2	3	4	9	5	0	0.0835	0.877	1.000
183	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(4), CCNE1(2), CDK2(2), CDK4(1), CDKN2A(5), E2F1(1), PRB1(7)	5508148	22	21	21	9	2	3	3	8	6	0	0.796	0.877	1.000
184	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(1), FUCA2(1), GLB1(4), HEXA(3), LCT(2), MAN2C1(5), NEU1(1)	9707266	17	16	17	3	2	2	2	10	1	0	0.305	0.878	1.000
185	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F2(3), F5(4), F7(1), FGA(1), FGG(1), PROC(4), PROS1(4), TFPI(1)	10095035	19	19	19	4	0	2	1	11	5	0	0.573	0.887	1.000
186	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	CTH(1), GGT1(2), LCMT1(1), LCMT2(3), MARS(2), MARS2(3), PAPSS1(3), PAPSS2(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), SEPHS1(1), SEPHS2(2)	15122744	26	25	26	3	3	2	7	10	4	0	0.0713	0.893	1.000
187	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(1), EGF(4), EGFR(7), GRB2(1), HRAS(1), MAPK3(1), PTPRB(3), RASA1(3), SHC1(2), SOS1(6), SPRY2(2), SPRY4(2), SRC(2)	15443263	35	32	34	6	4	11	5	10	5	0	0.0905	0.893	1.000
188	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(2), GREB1(10), HSPB2(1), MTA1(1), MTA3(1)	6525181	15	14	14	4	0	1	2	11	1	0	0.654	0.894	1.000
189	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(1), GPR171(1), GPR39(1), GPR45(3), GPR65(1), GPR75(1)	6086980	8	8	8	2	1	1	0	4	2	0	0.304	0.894	1.000
190	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA3(2), PSMA4(2), PSMA6(3), PSMB4(1), PSMB5(1), PSMB7(1)	5188358	10	10	10	3	0	1	1	5	3	0	0.807	0.894	1.000
191	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(1), AKT1(2), CSF2RB(1), IL3(1), KIT(3), KITLG(2), PIK3CA(12), PIK3R1(2), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1)	13399418	33	33	30	7	3	7	3	18	2	0	0.177	0.895	1.000
192	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	FUT1(1), GBGT1(2), HEXA(3), ST3GAL1(1), ST8SIA1(2)	6518339	9	9	9	2	2	1	1	5	0	0	0.414	0.897	1.000
193	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(2), FDPS(1), IDI1(1), LSS(2), PMVK(1), SC5DL(1)	6858053	8	8	8	1	0	0	1	6	1	0	0.517	0.898	1.000
194	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLRMT(1)	8092237	15	14	15	3	0	4	3	4	4	0	0.252	0.898	1.000
195	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(2), JAK1(4), JAK2(5), TYK2(3)	6430629	15	15	15	4	1	0	2	7	5	0	0.754	0.898	1.000
196	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(1), IL4R(2), JAK1(4), JAK2(5), TYK2(3)	6430629	15	15	15	4	1	0	2	7	5	0	0.754	0.898	1.000
197	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(1), MAP3K14(1), MAPK14(1), NFKB1(1), RELA(1), TNFRSF13B(1), TNFRSF17(1), TRAF3(1), TRAF5(3), TRAF6(1)	9068511	12	12	12	2	0	3	0	6	3	0	0.500	0.899	1.000
198	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(2), FDPS(1), HMGCS1(1), IDI1(1), LSS(2), PMVK(1), SC4MOL(1), SC5DL(1)	8180078	10	10	10	1	0	0	1	7	2	0	0.447	0.899	1.000
199	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(1), ALDH1A2(1), RDH5(2)	2390471	4	4	4	2	0	0	2	1	1	0	0.861	0.902	1.000
200	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(3), CYP2A13(2), NAT1(1), NAT2(2), XDH(2)	4930345	10	10	10	3	1	1	2	5	1	0	0.592	0.902	1.000
201	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	DAXX(4), FAS(1), FASLG(1), HSPB2(1), MAPKAPK2(2)	6815254	9	9	8	2	1	1	1	4	2	0	0.625	0.903	1.000
202	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	OXCT1(1)	2114168	1	1	1	1	0	0	0	0	1	0	0.967	0.905	1.000
203	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(2), EIF2AK4(3), EIF2B5(1), EIF2S2(1), EIF2S3(1), EIF5(2)	7115245	10	10	10	2	1	1	2	3	3	0	0.563	0.919	1.000
204	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(2), CCNE1(2), CDK2(2), CDK4(1), CDKN1A(1), E2F1(1), HRAS(1), MAPK3(1), NFKB1(1), PAK1(1), PIK3CA(12), PIK3R1(2), RAC1(1), RB1(1), RELA(1)	12535134	30	29	27	6	2	10	3	11	4	0	0.165	0.920	1.000
205	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(3), POLE(4), POLG(2), POLL(2), POLQ(5)	10216827	17	17	17	3	2	0	0	11	4	0	0.428	0.923	1.000
206	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(1), PDHA1(1), PDHA2(1), SLC18A3(1)	4103632	4	4	4	1	0	0	0	2	2	0	0.868	0.926	1.000
207	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	AGT(1), AKT1(2), CALM2(1), CALR(1), CAMK1(1), CAMK4(1), CREBBP(4), CSNK1A1(1), ELSPBP1(1), F2(3), FGF2(1), GATA4(1), HRAS(1), MAPK14(1), MAPK3(1), MYH2(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NPPA(1), PIK3CA(12), PIK3R1(2), PPP3CA(1), PPP3CC(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RPS6KB1(1), SYT1(1)	30760856	65	60	62	9	6	11	7	29	12	0	0.0138	0.926	1.000
208	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	DHRS2(1), LCMT1(1), LCMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1)	9112464	11	10	11	1	1	2	2	5	1	0	0.212	0.927	1.000
209	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1)	1903259	1	1	1	0	0	0	0	1	0	0	0.855	0.929	1.000
210	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	DPM2(1), ELK1(1), GRB2(1), HRAS(1), JUN(2), KLK2(1), MAPK3(1), NGFR(1), PIK3CA(12), PIK3R1(2), SHC1(2), SOS1(6)	11480316	31	30	28	7	2	10	3	15	1	0	0.259	0.932	1.000
211	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(2), CDK2(2), CUL1(3), E2F1(1), RB1(1), SKP2(1)	5409612	10	9	10	3	1	2	1	2	4	0	0.675	0.933	1.000
212	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), CFL1(1), CHN1(2), MAP3K1(5), MYL2(1), MYLK(4), NCF2(1), PAK1(1), PDGFRA(7), PIK3CA(12), PIK3R1(2), PLD1(2), RAC1(1), RALBP1(1), RPS6KB1(1), TRIO(2), VAV1(2)	21681433	46	41	43	6	1	7	4	23	11	0	0.0614	0.935	1.000
213	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(1), ITGAL(4), ITGAM(3), ITGB2(1), SELE(4)	6658595	13	13	13	4	1	4	3	3	2	0	0.583	0.940	1.000
214	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(2), IFNAR1(1), IFNB1(2), JAK1(4), STAT1(4), STAT2(3), TYK2(3)	6655388	19	19	19	5	1	4	2	7	5	0	0.427	0.941	1.000
215	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(1), HMOX1(2), JAK1(4), STAT1(4), STAT3(1)	7417728	12	12	12	3	1	0	0	7	4	0	0.769	0.942	1.000
216	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(2), AKT2(3), AKT3(2), BRAF(1), FIGF(3), HIF1A(3), MAPK3(1), PGF(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), RHEB(4), RICTOR(3), RPS6KA1(2), RPS6KA6(1), RPS6KB1(1), RPS6KB2(1), STK11(1), TSC1(2), TSC2(5), ULK1(1), ULK2(1), ULK3(3)	32763066	64	61	58	8	5	13	8	28	10	0	0.00489	0.945	1.000
217	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(1), GABRA3(2), GABRA4(2), GABRA5(1), PRKCE(4)	4893734	10	10	9	4	0	0	1	5	4	0	0.939	0.945	1.000
218	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(1), TOP2A(3), TOP2B(1)	6310068	5	5	5	0	2	1	0	2	0	0	0.278	0.948	1.000
219	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	SPCS1(1)	1919062	1	1	1	1	0	0	0	1	0	0	0.937	0.950	1.000
220	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	CAPN1(2), CSNK1A1(1), MAPT(1), PPP2CA(1)	5781880	5	5	5	0	0	0	1	1	3	0	0.368	0.951	1.000
221	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(1), ABP1(5), ACADM(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOC2(3), AOC3(1), CNDP1(3), DPYD(1), DPYS(2), ECHS1(2), EHHADH(3), GAD2(1), HADHA(1), MLYCD(1), SMS(2), UPB1(2)	16448248	35	33	35	7	3	5	11	10	6	0	0.163	0.956	1.000
222	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(2), DPM2(1), GRB2(1), HRAS(1), KLK2(1), NTRK1(4), PIK3CA(12), PIK3R1(2), SHC1(2), SOS1(6)	9495902	32	30	29	8	1	10	4	15	2	0	0.336	0.957	1.000
223	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CHPT1(1), LCMT1(1), LCMT2(3), PCYT1B(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1)	8602143	12	11	12	2	1	2	1	7	1	0	0.436	0.960	1.000
224	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(1), ACP2(1), ACP5(2), ENPP3(1), FLAD1(2), TYR(3)	6009360	10	10	10	3	0	3	0	4	3	0	0.725	0.960	1.000
225	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM2(1), CHUK(1), EGR2(1), EGR3(1), MAP3K1(5), MYC(1), NFATC1(1), NFATC2(1), NFKB1(1), PPP3CA(1), PPP3CC(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RELA(1), SYT1(1)	16701000	26	26	26	4	4	4	0	14	4	0	0.165	0.961	1.000
226	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(2), IFNB1(2), IL15(1), IL16(4), IL3(1), IL4(1), LTA(1)	5980500	12	12	12	4	0	5	1	6	0	0	0.533	0.963	1.000
227	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(1), C1R(3), C1S(1), C2(1), C3(6), C5(4), C7(2)	10747686	18	18	18	4	2	5	1	8	2	0	0.345	0.964	1.000
228	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(6), AXIN1(2), BTRC(2), CREBBP(4), CSNK1A1(1), CTBP1(1), CTNNB1(1), DVL1(1), FZD1(2), HDAC1(2), MAP3K7(1), MYC(1), PPARD(1), PPP2CA(1), TLE1(1), WIF1(1)	18016701	28	27	27	4	2	3	5	16	2	0	0.0782	0.966	1.000
229	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(1), FUCA2(1), GLB1(4), HEXA(3), LCT(2), MAN2B2(2), MAN2C1(5), NEU1(1)	12025433	19	17	19	3	2	2	3	11	1	0	0.223	0.967	1.000
230	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(2), ATIC(1), GART(1), MTHFD1(4), MTHFD1L(2), MTHFR(1), SHMT1(2), SHMT2(3)	11147479	16	16	16	3	3	2	0	7	4	0	0.392	0.967	1.000
231	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(1), IKBKAP(2), MAP3K1(5), MAP3K14(1), NFKB1(1), RELA(1), TRAF3(1), TRAF6(1)	11335637	13	12	13	2	0	3	0	4	6	0	0.405	0.967	1.000
232	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(2), CDK2(2), CUL1(3), E2F1(1), FBXW7(1), RB1(1)	5264017	10	9	10	4	1	2	1	2	4	0	0.852	0.968	1.000
233	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(2), AKT2(3), AKT3(2), GRB2(1), IARS(4), IL13RA1(1), IL4(1), IL4R(2), INPP5D(1), JAK1(4), JAK2(5), JAK3(4), PIK3CA(12), PPP1R13B(3), RPS6KB1(1), SHC1(2), SOS1(6), SOS2(1), SRC(2), STAT6(4), TYK2(3)	22603626	64	58	60	11	2	14	9	26	13	0	0.0744	0.969	1.000
234	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(2), IL3(1), IL4(1)	3759317	4	4	4	2	0	1	1	2	0	0	0.848	0.969	1.000
235	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	ASAH1(1), ITPKA(1), ITPKB(2)	3566789	4	4	4	2	1	0	0	1	2	0	0.926	0.969	1.000
236	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(2), ATIC(1), FTCD(1), GART(1), MTHFD1(4), MTHFD1L(2), MTHFR(1), SHMT1(2), SHMT2(3)	11799824	17	17	17	3	3	2	0	8	4	0	0.358	0.969	1.000
237	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(6), EIF4E(1), FBL(1), GPT(1), LDHB(1), LDHC(1), MAPK14(1), NCL(3)	5538188	15	15	15	6	0	0	4	7	4	0	0.938	0.970	1.000
238	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(5), ALDH3B1(1), ALDH3B2(2), AOC2(3), AOC3(1), DDC(2), EPX(1), GOT1(3), GOT2(2), MAOA(1), MPO(4), PRDX1(1), PRDX5(1), TPO(3)	13461982	30	26	30	6	2	4	9	11	4	0	0.207	0.971	1.000
239	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	CREBBP(4), PRF1(1)	6511345	5	5	5	0	0	2	1	2	0	0	0.193	0.973	1.000
240	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	11	CHST11(1), CHST12(1), PAPSS1(3), PAPSS2(2), SULT1A1(1), SULT2A1(1), SUOX(2)	5320563	11	11	11	4	2	0	4	1	4	0	0.827	0.974	1.000
241	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(15), ATR(5), BRCA1(6), CDC25A(1), CDC25C(2), CDKN1A(1), CHEK2(3), EP300(6), MYT1(2), PRKDC(7), RPS6KA1(2), TP53(10), WEE1(1)	26752095	61	53	59	9	3	6	11	29	12	0	0.0555	0.975	1.000
242	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(4), EP300(6), LPL(1), NCOA1(2), NCOA2(2), PPARG(1)	11432703	16	16	16	3	2	2	4	7	1	0	0.261	0.975	1.000
243	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(2), ALDOB(3), FBP1(1), GOT1(3), GOT2(2), GPT(1), GPT2(1), MDH1(1), ME1(1), ME2(2), ME3(2), PGK1(2), PKM2(1), RPE(1), TPI1(1)	10998103	24	23	24	6	0	3	4	6	11	0	0.608	0.975	1.000
244	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(1), IFNA1(2), IFNB1(2), IL1R1(1), IL1RAP(4), IRAK1(3), IRAK3(2), JUN(2), MAP2K3(9), MAP2K6(1), MAP3K1(5), MAP3K14(1), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(1), TGFB2(2), TGFB3(1), TRAF6(1)	18348027	41	38	36	7	7	8	0	19	7	0	0.128	0.976	1.000
245	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), XYLT1(1), XYLT2(2)	3640818	4	4	4	2	1	2	0	1	0	0	0.656	0.976	1.000
246	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(1), XYLT1(1), XYLT2(2)	3640818	4	4	4	2	1	2	0	1	0	0	0.656	0.976	1.000
247	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), MIOX(2)	5230020	8	8	8	3	0	2	0	3	3	0	0.822	0.976	1.000
248	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	IL4(1), JUNB(2), MAF(1), MAP2K3(9), MAPK14(1), NFATC1(1), NFATC2(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1)	6884313	25	22	21	8	7	0	1	16	1	0	0.537	0.977	1.000
249	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(1), ST3GAL5(1), ST6GALNAC2(2), ST8SIA1(2)	3382326	7	7	7	3	0	2	1	4	0	0	0.684	0.978	1.000
250	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(3), PAPSS2(2), SULT2A1(1), SUOX(2)	3799740	8	8	8	3	1	0	4	1	2	0	0.701	0.978	1.000
251	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), DHRS2(1), ESCO1(2), ESCO2(1), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1)	15436406	23	22	22	4	2	2	3	12	4	0	0.369	0.980	1.000
252	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	12	AKT1(2), CAT(2), GHR(1), HRAS(1), PIK3CA(12), PIK3R1(2), SHC1(2)	8024432	22	22	19	6	1	7	3	9	2	0	0.407	0.981	1.000
253	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(1), ARSB(1), FUCA2(1), GALNS(2), GBA(2), GLB1(4), GNS(1), GUSB(6), HEXA(3), HGSNAT(1), HPSE(2), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(2), MAN2B2(2), MAN2C1(5), NEU1(1), SPAM1(4)	20800172	46	37	44	8	7	6	7	22	4	0	0.0524	0.981	1.000
254	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(2), APC(6), AR(1), ASAH1(1), BRAF(1), EGFR(7), GNA15(1), GNAI1(1), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(8), ITPR3(3), KCNJ3(3), MAPK10(1), MAPK14(1), PHKA2(3), PIK3CA(12), PIK3R1(2), PITX2(1), SRC(2)	33003649	61	51	57	7	5	15	10	25	6	0	0.00118	0.982	1.000
255	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	DPM2(1), EGR1(2), HRAS(1), KLK2(1), MAPK3(1), NGFR(1)	4965774	7	7	7	3	2	1	0	4	0	0	0.757	0.982	1.000
256	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(2), AKT2(3), AKT3(2), BCR(1), BTK(1), CD19(1), CDKN2A(5), GAB1(1), ITPR1(2), ITPR2(8), ITPR3(3), PDK1(1), PHF11(1), PIK3CA(12), PITX2(1), PLCG2(1), PPP1R13B(3), PREX1(6), PTEN(20), PTPRC(6), RPS6KA1(2), RPS6KB1(1), SAG(2), SYK(1), TEC(5), VAV1(2)	34254072	93	83	90	15	7	18	9	33	25	1	0.00664	0.982	1.000
257	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(1), CLOCK(1), PER1(4), PER2(3), PER3(2)	10468412	11	11	11	2	1	0	4	4	1	1	0.324	0.982	1.000
258	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(1), ADRB2(2), CFTR(4), GNAS(4), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1)	7871603	20	20	20	5	2	2	0	13	3	0	0.758	0.983	1.000
259	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), TH(1), TPH1(1)	3613727	4	4	4	2	0	1	1	1	1	0	0.864	0.983	1.000
260	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(1), LDLR(1), LPL(1)	3253171	3	3	3	2	0	2	0	1	0	0	0.850	0.984	1.000
261	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(4), JAK2(5), JAK3(4), MAPK3(1), STAT3(1), TYK2(3)	7221566	18	18	18	8	1	0	3	9	5	0	0.939	0.985	1.000
262	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(2), ALDOB(3), FBP1(1), GOT1(3), GOT2(2), GPT(1), GPT2(1), MDH1(1), ME1(1), ME3(2), PGK1(2), PKM2(1), RPE(1), TKTL1(1), TKTL2(3), TPI1(1)	12309174	26	26	26	6	0	2	4	8	12	0	0.612	0.985	1.000
263	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	CAPN1(2), EGF(4), EGFR(7), HRAS(1), ITGA1(3), ITGB1(3), MAPK3(1), MYL2(1), MYLK(4), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PTK2(1), TLN1(4)	20377128	40	39	39	7	6	4	4	18	8	0	0.200	0.985	1.000
264	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(2), B3GAT2(1), B3GAT3(1), CHST11(1), CHST12(1), CHST7(1), CHSY1(3), DSE(1), XYLT1(1), XYLT2(2)	7571863	14	14	14	4	2	4	0	5	3	0	0.433	0.986	1.000
265	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT1(1), GBGT1(2), HEXA(3), ST3GAL1(1), ST8SIA1(2)	6143964	9	9	9	3	2	1	1	5	0	0	0.600	0.986	1.000
266	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	IFNAR1(1), IFNB1(2), NFKB1(1), RELA(1), TRAF6(1)	6682612	6	6	6	2	0	4	0	1	1	0	0.664	0.988	1.000
267	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	26	ABP1(5), ALDH3B1(1), ALDH3B2(2), AOC2(3), AOC3(1), DDC(2), EPX(1), ESCO1(2), ESCO2(1), GOT1(3), GOT2(2), MAOA(1), MPO(4), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1), TPO(3)	20920218	42	37	42	7	3	5	10	18	6	0	0.0994	0.989	1.000
268	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(15), CDC25A(1), CDC25C(2), CDK2(2), CDK4(1), MYT1(2), RB1(1), TP53(10), WEE1(1)	11054004	35	29	35	9	2	4	6	14	9	0	0.502	0.990	1.000
269	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(2), RIPK1(1), TNFRSF1A(1), TRADD(1)	4852865	6	6	6	3	0	3	1	1	1	0	0.770	0.990	1.000
270	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT3(1), B4GALT5(1), ST3GAL1(1), ST3GAL3(1)	4775395	4	4	4	4	0	0	1	1	2	0	0.986	0.991	1.000
271	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(3), CD3E(2), CD3G(1), CD4(2), IL12RB1(1), IL12RB2(2), JAK2(5), STAT4(1), TYK2(3)	9171081	20	18	19	5	1	2	3	12	2	0	0.499	0.991	1.000
272	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(1), IFNB1(2), JAK1(4), PTPRU(4), STAT1(4), STAT2(3), TYK2(3)	7631359	21	21	21	6	1	2	2	11	5	0	0.560	0.992	1.000
273	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA2A(1), ADORA2B(1), P2RY2(1), P2RY6(1)	3391119	4	4	4	5	0	0	0	3	1	0	0.986	0.992	1.000
274	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15B(2), ALOX5(2), GGT1(2), LTA4H(4), PLA2G6(2), PTGDS(1), PTGES(1), PTGS1(1), PTGS2(4), TBXAS1(1)	9356670	20	19	19	5	1	3	6	6	4	0	0.386	0.993	1.000
275	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(15), CDC25A(1), CDC25C(2), MYT1(2), WEE1(1)	8602771	21	18	21	5	0	2	3	10	6	0	0.561	0.993	1.000
276	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	EGF(4), EGFR(7), ELK1(1), GRB2(1), HRAS(1), JAK1(4), JUN(2), MAP3K1(5), MAPK3(1), PIK3CA(12), PIK3R1(2), RASA1(3), SHC1(2), SOS1(6), SRF(1), STAT1(4), STAT3(1)	23032826	57	55	53	10	4	12	6	25	10	0	0.0859	0.994	1.000
277	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(6), CD33(1), CD7(3), IFNA1(2), IFNB1(2), IL3(1), IL4(1), ITGAX(2), TLR2(2), TLR4(2), TLR7(2), TLR9(1)	11312503	25	25	25	7	2	5	5	9	3	1	0.568	0.994	1.000
278	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(2), B3GNT7(1), B4GALT3(1), B4GALT4(2), CHST1(1), CHST4(1), ST3GAL1(1), ST3GAL3(1)	7106875	10	10	10	4	0	3	2	1	4	0	0.798	0.995	1.000
279	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ADCY1(1), CAP1(1), CDC25C(2), GNAI1(1), GNAS(4), GNB1(2), HRAS(1), MAPK3(1), MYT1(2), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RPS6KA1(2), SRC(2)	12410831	28	27	28	7	4	3	0	18	3	0	0.519	0.995	1.000
280	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	BIRC2(3), BIRC3(2), CASP10(3), CASP7(1), PRF1(1), SCAP(1), SREBF1(2), SREBF2(3)	10984503	16	16	16	4	1	5	1	6	3	0	0.495	0.996	1.000
281	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(1), GRB2(1), HRAS(1), IL3(1), JAK2(5), MAPK3(1), PTPN6(3), SHC1(2), SOS1(6), STAT5B(1)	10810069	22	21	22	5	3	3	3	11	2	0	0.377	0.996	1.000
282	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(4), ATM(15), ATR(5), CCNA1(4), CCNE1(2), CDC25A(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(5), E2F1(1), HDAC1(2), RB1(1), SKP2(1), TGFB2(2), TGFB3(1), TP53(10)	18505183	58	47	58	11	5	9	7	22	15	0	0.160	0.996	1.000
283	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(4), JAK2(5), JAK3(4), PIAS1(2), PTPRU(4)	8521358	19	16	19	5	0	1	3	10	5	0	0.656	0.996	1.000
284	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(2), GRB2(1), HRAS(1), IRS1(3), MAPK3(1), PIK3CA(12), PIK3R1(2), SHC1(2), SOS1(6)	11398430	30	29	27	8	3	10	3	13	1	0	0.273	0.997	1.000
285	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(1), NOTCH1(5)	5132206	6	6	6	3	2	1	0	3	0	0	0.799	0.997	1.000
286	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	BDH1(1), BDH2(1), HMGCS1(1), HMGCS2(1), OXCT1(1)	4476618	5	5	5	3	0	1	0	3	1	0	0.949	0.997	1.000
287	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	17	DNAJA3(1), IFNGR1(2), IFNGR2(1), JAK2(5), NFKB1(1), RB1(1), RELA(1), TNFRSF1A(1), TP53(10), USH1C(3), WT1(3)	11014022	29	27	29	9	2	5	4	11	7	0	0.654	0.997	1.000
288	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(2), NDUFB6(1), NDUFS1(4), NDUFS2(1), NDUFV2(1)	4381376	9	9	9	4	0	0	1	7	1	0	0.921	0.997	1.000
289	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(3), ADRBK2(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CLCA4(2), CNGA3(3), CNGA4(2), CNGB1(2), GUCA1B(1), PDC(1), PDE1C(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKG1(2), PRKG2(2)	19142752	33	31	33	6	4	5	3	18	3	0	0.202	0.997	1.000
290	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(1), GTF2E2(2), GTF2F1(1), GTF2F2(1), GTF2H1(2), GTF2I(3), GTF2IRD1(1), STON1(1), TAF1(5), TAF13(1), TAF1L(4), TAF2(2), TAF4(2), TAF4B(2), TAF5(2), TAF5L(2), TAF6(1), TAF7L(4)	22125447	37	36	37	6	2	4	4	22	5	0	0.160	0.998	1.000
291	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR7(2), FDPS(1), IDI1(1), IDI2(2), LSS(2), PMVK(1), SC4MOL(1), SC5DL(1), TM7SF2(1)	11924405	12	12	12	2	0	0	1	8	3	0	0.591	0.998	1.000
292	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(2), AGT(1), AGTR1(1), BDKRB2(1), KNG1(2), NOS3(2), REN(1)	5996482	10	9	10	4	1	2	2	4	1	0	0.701	0.998	1.000
293	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	BCL10(1), BID(1), CASP8AP2(4), CES1(2)	7145394	8	8	8	3	0	1	0	4	3	0	0.874	0.998	1.000
294	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAS1(4), ALAS2(3), CPOX(1), FECH(2)	4773876	10	10	9	4	0	0	2	7	1	0	0.833	0.998	1.000
295	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CYB5R3(2), GFPT1(1), GNPDA1(1), HEXA(3), HK1(4), RENBP(2)	10526097	13	12	13	3	3	0	2	6	2	0	0.488	0.998	1.000
296	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	ELK1(1), GRB2(1), HRAS(1), JAK1(4), JUN(2), MAP3K1(5), MAPK3(1), PDGFRA(7), PIK3CA(12), PIK3R1(2), RASA1(3), SHC1(2), SOS1(6), SRF(1), STAT1(4), STAT3(1)	21462996	53	51	50	10	3	11	4	26	9	0	0.122	0.998	1.000
297	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(1), ACP2(1), ACP5(2), ACP6(1), ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), CYP3A7(1), DHRS2(1), PON3(2)	10895365	19	18	19	5	1	5	2	9	2	0	0.407	0.998	1.000
298	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	DAB1(3), FYN(1), LRP8(1), RELN(3), VLDLR(2)	8652493	10	10	10	3	0	3	0	5	2	0	0.822	0.998	1.000
299	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(5), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(1), ALDH3B2(2), AOC2(3), AOC3(1), ASPA(1), CNDP1(3), DDC(2), HARS(1), MAOA(1), PRPS1(1), PRPS2(2)	15001144	30	28	30	7	2	6	7	12	3	0	0.269	0.998	1.000
300	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(1), SRP19(1), SRP68(2), SRP72(2), SRP9(1)	4691704	7	7	7	3	0	2	1	4	0	0	0.825	0.998	1.000
301	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(4), CCND2(1), CCNE1(2), CCNH(1), CDC25A(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(5), CDKN2C(1), E2F1(1), RB1(1)	9811377	21	20	21	7	2	3	2	8	6	0	0.744	0.998	1.000
302	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AIFM1(3), AKT1(2), AKT2(3), AKT3(2), ATM(15), BID(1), BIRC2(3), BIRC3(2), CAPN1(2), CASP10(3), CASP7(1), CFLAR(1), CHUK(1), CSF2RB(1), FAS(1), FASLG(1), IL1R1(1), IL1RAP(4), IL3(1), IRAK1(3), IRAK3(2), IRAK4(1), MAP3K14(1), NFKB1(1), NTRK1(4), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RELA(1), RIPK1(1), TNFRSF1A(1), TNFSF10(1), TP53(10), TRADD(1)	51677192	111	99	106	16	8	21	15	49	18	0	0.00245	0.998	1.000
303	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1)	8252375	13	13	12	5	1	1	0	7	4	0	0.910	0.998	1.000
304	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	F2(3), FGA(1), FGG(1), PLAT(2), PLAU(4), PLG(5)	8404887	16	16	16	5	0	1	3	8	4	0	0.737	0.998	1.000
305	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(1), IKBKAP(2), LTA(1), MAP3K1(5), MAP3K14(1), NFKB1(1), RELA(1), RIPK1(1), TANK(1), TRAF3(1)	13819333	15	14	15	3	1	3	0	5	6	0	0.418	0.999	1.000
306	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1)	4892942	7	7	7	5	0	1	1	4	1	0	0.971	0.999	1.000
307	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1)	4892942	7	7	7	5	0	1	1	4	1	0	0.971	0.999	1.000
308	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(1), ABP1(5), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), AOC2(3), AOC3(1), CNDP1(3), DPYD(1), DPYS(2), ECHS1(2), EHHADH(3), GAD2(1), HADHA(1), MLYCD(1), SMS(2), UPB1(2)	17731273	36	34	36	9	3	5	12	11	5	0	0.307	0.999	1.000
309	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	65	ATM(15), ATR(5), BAI1(1), BID(1), CCNB2(5), CCNB3(6), CCND2(1), CCNE1(2), CCNG2(1), CD82(2), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(5), CHEK2(3), FAS(1), GTSE1(2), IGFBP3(1), LRDD(1), PTEN(20), RFWD2(2), RRM2(1), SERPINB5(3), STEAP3(2), THBS1(6), TP53(10), TP53I3(4), TP73(3), TSC2(5)	39981246	112	90	111	18	10	13	16	35	37	1	0.0147	0.999	1.000
310	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(2), CALCR(1), CD97(3), CRHR2(1), ELTD1(2), EMR1(1), EMR2(2), GIPR(1), GLP1R(1), GLP2R(2), GPR64(2), LPHN1(1), LPHN2(2), LPHN3(7), SCTR(1), VIPR1(1)	17047766	30	28	30	6	3	4	3	16	4	0	0.186	0.999	1.000
311	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(2), ATM(15), BID(1), CASP7(1), PTK2(1), STAT1(4), TLN1(4), TP53(10)	17122645	38	33	38	8	4	5	5	16	8	0	0.271	0.999	1.000
312	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(1), PLCB1(1), RELA(1)	5102963	3	3	3	3	0	2	0	0	1	0	0.921	0.999	1.000
313	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	JAK1(4), JAK2(5), JAK3(4), PTPRU(4), SRC(2), STAT3(1)	9373255	20	18	20	8	0	2	2	11	5	0	0.917	0.999	1.000
314	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(4), APOBEC1(1), APOBEC3B(1), APOBEC4(1)	4578285	7	6	7	5	1	0	2	3	1	0	0.951	0.999	1.000
315	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(1), CREBBP(4), EP300(6), NFKB1(1), RELA(1), RIPK1(1), TNFRSF1A(1), TRADD(1), TRAF6(1)	13582745	17	17	17	4	0	4	5	5	3	0	0.397	0.999	1.000
316	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACADM(1), ACADS(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), AOX1(7), BCAT1(1), ECHS1(2), EHHADH(3), HADHA(1), HADHB(2), HIBADH(1), IVD(1), MCCC1(2), MCCC2(4), MCEE(1), MUT(2), OXCT1(1), PCCA(1), PCCB(2)	22330728	41	41	40	9	3	7	8	17	6	0	0.270	0.999	1.000
317	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(4), KHK(4), LCT(2), MPI(1), PYGL(1), PYGM(2), TPI1(1), TREH(2)	8385889	17	16	16	5	3	0	4	6	4	0	0.611	0.999	1.000
318	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(1), ACP2(1), ACP5(2), ACP6(1), ENPP3(1), FLAD1(2), MTMR1(1), MTMR2(1), TYR(3)	9325297	13	13	13	4	0	3	0	7	3	0	0.754	0.999	1.000
319	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(8), ITPR3(3), NFAT5(7), PDE6A(1), PDE6B(2), PDE6C(2), SLC6A13(2)	22326766	35	31	34	6	4	3	6	17	5	0	0.121	0.999	1.000
320	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	12	JUN(2), KEAP1(2), MAPK14(1), NFE2L2(6)	5381736	11	11	11	5	0	1	2	7	1	0	0.864	0.999	1.000
321	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(5), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(1), ALDH3B2(2), ALDH7A1(1), AMDHD1(1), AOC2(3), AOC3(1), ASPA(1), CNDP1(3), DDC(2), FTCD(1), HARS(1), HARS2(1), LCMT1(1), LCMT2(3), MAOA(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), PRPS1(1), PRPS2(2), UROC1(1)	24273581	43	37	43	7	3	10	8	17	5	0	0.0534	0.999	1.000
322	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(3), CS(2), MDH1(1), ME1(1), PC(1), PDHA1(1)	5716800	9	9	9	4	0	3	1	4	1	0	0.700	0.999	1.000
323	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	24	ATM(15), BMPR1B(1), CCND2(1), CDK4(1), EGR1(2), ESR2(1), GJA4(1), MLH1(1), NCOR1(5), NRIP1(6), PGR(1), PRLR(2), PTGER2(1), SMPD1(1), VDR(1), ZP2(1)	21016551	41	36	41	7	2	7	6	17	9	0	0.0872	0.999	1.000
324	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(1), ACADM(1), ACADS(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOX1(7), BCAT1(1), DLD(2), ECHS1(2), EHHADH(3), HADH(1), HADHA(1), HADHB(2), HIBADH(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), IVD(1), MCCC1(2), MCCC2(4), MCEE(1), MUT(2), OXCT1(1), PCCA(1), PCCB(2)	26726464	47	47	46	9	4	7	10	19	7	0	0.140	0.999	1.000
325	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(6), AXIN1(2), BTRC(2), CTNNB1(1), DLL1(1), DVL1(1), FZD1(2), NOTCH1(5)	12458770	20	20	19	5	3	3	3	11	0	0	0.350	0.999	1.000
326	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), GLB1(4), HEXA(3), LCT(2), SLC33A1(2), ST3GAL1(1), ST3GAL5(1), ST6GALNAC3(2), ST6GALNAC5(2), ST8SIA1(2), ST8SIA5(1)	9926916	21	20	21	6	2	4	2	10	3	0	0.425	0.999	1.000
327	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(2), HLA-A(4), ITGB1(3), KLRC1(2), KLRC2(4), MAPK3(1), PAK1(1), PIK3CA(12), PIK3R1(2), PTK2B(2), PTPN6(3), RAC1(1), SYK(1), VAV1(2)	11559475	40	36	36	10	2	12	5	12	9	0	0.338	0.999	1.000
328	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(6), RPE(1), UGP2(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B10(1), UGT2B11(2), UGT2B15(1), UGT2B28(1), UGT2B4(2), UGT2B7(2), XYLB(1)	16942394	33	29	31	8	2	5	6	13	7	0	0.404	0.999	1.000
329	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(3), CD3E(2), CD3G(1), IL12RB1(1), IL12RB2(2), IL18R1(1), JAK2(5), JUN(2), MAP2K6(1), MAPK14(1), STAT4(1), TYK2(3)	11604034	23	21	22	6	1	1	3	16	2	0	0.619	0.999	1.000
330	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR2(1), ITPKA(1), PDE1A(1), PDE1B(2), PLCB1(1), PLCB2(2)	6781922	8	8	8	5	1	1	0	4	2	0	0.932	0.999	1.000
331	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(1), C1R(3), C1S(1), C2(1), C3(6), C5(4), C7(2), C8B(2), MASP1(1)	12799458	21	21	21	5	4	5	1	9	2	0	0.321	0.999	1.000
332	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), CYP2C19(1), DHRS2(1), ECHS1(2), EHHADH(3), ESCO1(2), ESCO2(1), HADHA(1), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1), YOD1(1)	19051907	29	27	29	5	2	4	4	13	6	0	0.245	0.999	1.000
333	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(1), MBTPS1(2), SCAP(1), SREBF1(2), SREBF2(3)	7158734	10	10	10	4	1	3	1	2	3	0	0.785	0.999	1.000
334	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CHUK(1), ELK1(1), IRAK1(3), JUN(2), LY96(1), MAP2K3(9), MAP2K6(1), MAP3K1(5), MAP3K14(1), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(1), TLR10(1), TLR2(2), TLR4(2), TLR6(1), TLR7(2), TLR9(1), TRAF6(1)	22241562	38	34	34	7	5	6	1	18	8	0	0.201	0.999	1.000
335	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(9), ARHGEF1(1), GNA13(4), GNB1(2), MYL2(1), MYLK(4), PLCB1(1), ROCK1(4)	12616665	26	24	24	7	0	3	2	14	6	1	0.567	1.000	1.000
336	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(1), ARHGEF1(1), F2(3), GNA13(4), GNAI1(1), GNB1(2), MAP3K7(1), PIK3CA(12), PIK3R1(2), PLCB1(1), PTK2B(2), ROCK1(4)	15834125	34	33	31	8	0	8	3	16	7	0	0.311	1.000	1.000
337	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(4), CS(2), GRHPR(2), MDH1(1), MTHFD1(4), MTHFD1L(2)	7967216	15	15	15	5	3	1	2	8	1	0	0.605	1.000	1.000
338	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(1), DLG4(1), GRIN1(2), GRIN2A(4), GRIN2B(5), NOS1(8), PPP3CA(1), PPP3CC(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), SYT1(1)	15677959	33	32	33	9	6	7	1	19	0	0	0.362	1.000	1.000
339	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(1), C1R(3), C1S(1), C2(1), C3(6), C5(4), C7(2), MASP1(1), MASP2(1), MBL2(1)	13155421	21	21	21	5	3	6	1	9	2	0	0.307	1.000	1.000
340	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(1), DPYD(1), DPYS(2), ENPP3(1), PANK1(2), PANK2(3), PANK3(1), PANK4(1), UPB1(2)	8506571	15	14	15	5	1	3	4	5	2	0	0.587	1.000	1.000
341	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(3), ACO1(4), ACSS1(3), ACSS2(3), IDH1(2), MDH1(1)	8259902	16	15	16	7	1	3	2	7	3	0	0.849	1.000	1.000
342	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), SHMT1(2)	9429484	13	13	13	6	0	1	3	5	4	0	0.925	1.000	1.000
343	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), SHMT1(2)	9429484	13	13	13	6	0	1	3	5	4	0	0.925	1.000	1.000
344	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), SHMT1(2)	9429484	13	13	13	6	0	1	3	5	4	0	0.925	1.000	1.000
345	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(1), CDC25C(2), CSK(2), GRB2(1), PTPRA(1), SRC(2)	5682399	9	9	9	4	0	4	0	5	0	0	0.731	1.000	1.000
346	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	CS(2), MDH1(1), OGDH(3), SDHA(1)	5886443	7	7	7	6	1	1	1	3	1	0	0.985	1.000	1.000
347	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(4), CS(2), GRHPR(2), MDH1(1), MTHFD1(4), MTHFD1L(2)	8361460	15	15	15	5	3	1	2	8	1	0	0.604	1.000	1.000
348	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(1), GABRA1(1), GABRA3(2), GABRA4(2), GABRA5(1), GPHN(3), SRC(2), UBQLN1(1)	7410165	13	13	13	5	0	4	3	4	2	0	0.751	1.000	1.000
349	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	HK1(4)	6297228	4	3	4	3	2	0	0	1	1	0	0.925	1.000	1.000
350	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ECHS1(2), EHHADH(3), HADHA(1)	7514224	13	13	13	5	1	3	2	5	2	0	0.764	1.000	1.000
351	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	FAU(1), MRPS7(1), RPL10A(1), RPL11(1), RPL18(2), RPL18A(1), RPL19(1), RPL22L1(1), RPL27(2), RPL28(1), RPL3(1), RPL30(2), RPL31(1), RPL34(1), RPL3L(1), RPL7(1), RPS11(1), RPS13(1), RPS2(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1)	14030803	32	31	32	7	2	3	6	17	4	0	0.290	1.000	1.000
352	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), IARS(4), IARS2(2), ILVBL(1), LARS(3), LARS2(1), PDHA1(1), PDHA2(1), PDHB(1), VARS(2), VARS2(1)	10458655	18	16	17	7	0	4	1	8	5	0	0.836	1.000	1.000
353	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(4), EP300(6), FYN(1), JAK1(4), JAK3(4), PIK3CA(12), PIK3R1(2), PTK2B(2), STAT5B(1)	17367079	36	34	33	9	0	9	7	15	5	0	0.381	1.000	1.000
354	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	37	ANPEP(6), G6PD(2), GGT1(2), GPX3(2), GPX4(1), GPX5(1), GPX6(1), GSR(1), GSS(1), GSTA3(1), GSTA4(1), GSTM1(1), GSTM5(1), IDH1(2), MGST3(2), OPLAH(4), TXNDC12(1)	13487704	30	28	28	9	2	0	7	12	9	0	0.838	1.000	1.000
355	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(1), ITGA4(1), ITGAL(4), ITGB1(3), ITGB2(1), SELE(4)	7632567	14	14	14	5	1	4	4	3	2	0	0.647	1.000	1.000
356	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), SHMT1(2)	9951143	13	13	13	6	0	1	3	5	4	0	0.924	1.000	1.000
357	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(1), DBH(2), DDC(2), GAD2(1), MAOA(1), PAH(3), SLC18A3(1), TH(1), TPH1(1)	8603208	13	12	13	6	0	2	4	4	3	0	0.881	1.000	1.000
358	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(2), PIK3CA(12), PIK3R1(2), PLCB1(1), VAV1(2)	7995805	19	19	16	8	1	7	3	6	2	0	0.685	1.000	1.000
359	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(1), CA14(2), CA5B(2), CA7(1), CA9(2), CPS1(6), CTH(1), GLS(4), GLS2(2)	11750482	21	21	21	6	1	3	3	14	0	0	0.542	1.000	1.000
360	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(1), IL1R1(1), IRAK1(3), MAP3K1(5), MAP3K14(1), MAP3K7(1), NFKB1(1), RELA(1), RIPK1(1), TLR4(2), TNFRSF1A(1), TRADD(1), TRAF6(1)	14751144	20	18	20	6	1	5	1	5	8	0	0.621	1.000	1.000
361	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(2), ALDOB(3), FBP1(1), G6PD(2), PFKM(2), PRPS1(1), PRPS1L1(1), PRPS2(2), RPE(1), TALDO1(2)	12255271	17	17	17	9	0	3	2	6	6	0	0.954	1.000	1.000
362	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(6), ATF2(1), AXIN1(2), BMP2(1), BMP5(1), BMP7(2), BMPR2(4), CHRD(2), CTNNB1(1), DVL1(1), FZD1(2), GATA4(1), MAP3K7(1), MYL2(1), NPPA(1), NPPB(1), RFC1(4), TGFB2(2), TGFB3(1), TGFBR2(1), TGFBR3(1)	22030650	37	35	37	7	2	6	3	23	3	0	0.168	1.000	1.000
363	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT1(2), AKT2(3), AKT3(2), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(8), ITPR3(3), NFKB1(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(1), PITX2(1), PLD1(2), PLD2(2), PLD3(3)	27547566	40	33	40	6	3	8	6	16	7	0	0.0323	1.000	1.000
364	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(4), CS(2), DLD(2), DLST(1), IDH1(2), IDH3B(1), IDH3G(1), MDH1(1), PC(1), PCK1(4), SDHA(1), SDHB(1), SUCLG1(5), SUCLG2(1)	12807968	27	26	27	9	3	1	4	13	6	0	0.767	1.000	1.000
365	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	HK1(4), IMPA2(2)	7125667	6	5	6	4	3	0	0	2	1	0	0.924	1.000	1.000
366	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(2), ADCY6(1), ADCY8(6), CACNA1A(5), CACNA1B(4), GNAS(4), GNB1(2), GNG3(1), GRM4(3), ITPR3(3), PDE1A(1), PLCB2(2), PRKACA(1), PRKACB(4), PRKACG(2), SCNN1A(2), SCNN1B(2), SCNN1G(1), TAS1R1(1), TAS1R2(4), TAS1R3(2), TAS2R1(1), TAS2R13(1), TAS2R16(1), TAS2R3(2), TAS2R38(3), TAS2R39(1), TAS2R42(1), TAS2R43(1), TAS2R46(1), TAS2R50(1), TAS2R60(1), TAS2R8(1), TAS2R9(1), TRPM5(1)	35196925	70	62	69	12	13	4	7	29	16	1	0.0977	1.000	1.000
367	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(6), AXIN1(2), CREBBP(4), CTNNB1(1), DVL1(1), EP300(6), FZD1(2), HDAC1(2), LDB1(1), LEF1(1), PITX2(1), TRRAP(3)	20298608	30	29	30	6	1	3	7	18	1	0	0.209	1.000	1.000
368	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	ASAH1(1), BFAR(1), BRAF(1), SNX13(2), SRC(2)	7140864	7	7	7	5	0	3	0	3	1	0	0.948	1.000	1.000
369	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	ALOX5(2), CBR1(2), CYP4F2(1), EPX(1), GGT1(2), LTA4H(4), MPO(4), PLA2G4A(1), PLA2G6(2), PRDX1(1), PRDX5(1), PTGDS(1), PTGS1(1), PTGS2(4), TBXAS1(1), TPO(3)	17084735	31	31	30	8	4	5	8	10	4	0	0.280	1.000	1.000
370	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(2), CABIN1(6), CALM2(1), CAMK1(1), INSR(3), MAP2K6(1), MAPK14(1), MEF2A(2), MEF2D(1), NFATC1(1), NFATC2(1), PIK3CA(12), PIK3R1(2), PPP3CA(1), PPP3CC(1), SYT1(1)	21068820	37	37	34	9	3	10	5	14	5	0	0.233	1.000	1.000
371	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(1), ITGA4(1), ITGAL(4), ITGAM(3), ITGB1(3), ITGB2(1), SELE(4), SELP(1)	10101136	18	18	18	7	1	5	5	4	3	0	0.750	1.000	1.000
372	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA3(2), PSMA4(2), PSMA6(3), PSMB4(1), PSMB5(1), PSMB7(1), PSMD11(1), PSMD2(2), PSMD6(1)	9978802	14	14	14	6	1	2	1	7	3	0	0.913	1.000	1.000
373	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(1), ABAT(1), ADSL(1), AGXT(1), AGXT2(1), ASL(1), ASNS(1), ASPA(1), CAD(4), CRAT(1), DARS(1), GAD2(1), GOT1(3), GOT2(2), GPT(1), GPT2(1), PC(1)	16111652	23	22	23	7	1	2	7	4	9	0	0.613	1.000	1.000
374	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	ARSB(1), ARSD(7), ARSE(1), CYP11B2(2), HSD17B8(1), HSD3B1(1), SULT2A1(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2)	16843009	25	22	23	9	2	2	3	9	9	0	0.831	1.000	1.000
375	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(2), CASP2(1), CHUK(1), JUN(2), LTA(1), MAP2K3(9), MAP2K6(1), MAP3K1(5), MAP3K14(1), MAP4K2(1), MAPK14(1), NFKB1(1), RELA(1), RIPK1(1), TANK(1), TNFRSF1A(1), TRADD(1)	14782944	31	28	27	9	5	3	1	16	6	0	0.669	1.000	1.000
376	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(6), C5(4), C7(2), ITGA4(1), ITGAL(4), ITGB1(3), ITGB2(1), SELP(1), SELPLG(1), VCAM1(1)	15393560	24	24	24	7	2	4	4	10	4	0	0.507	1.000	1.000
377	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(1), CA14(2), CA5B(2), CA7(1), CA9(2), CPS1(6), CTH(1), GLS(4), GLS2(2)	13113172	21	21	21	6	1	3	3	14	0	0	0.539	1.000	1.000
378	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(1), BCR(1), ELK1(1), GRB2(1), HRAS(1), JUN(2), MAP3K1(5), MAPK3(1), MAPK8IP3(1), PAPPA(1), RAC1(1), RPS6KA1(2), SHC1(2), SOS1(6), SYK(1), VAV1(2), VAV2(4)	19485389	33	30	33	8	4	5	3	18	3	0	0.312	1.000	1.000
379	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	MAP3K1(5), MAPK3(1), NFKB1(1), NSMAF(3), RELA(1), RIPK1(1), SMPD1(1), TNFRSF1A(1), TRADD(1)	12585853	15	15	15	5	1	4	1	4	5	0	0.564	1.000	1.000
380	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(4), ATM(15), BRCA1(6), CDKN1A(1), CHEK2(3), JUN(2), NFKB1(1), RAD50(4), RAD51(2), RELA(1), TP53(10), TP73(3)	18215089	52	46	51	11	4	8	9	21	10	0	0.216	1.000	1.000
381	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(2), ALDOB(3), FBP1(1), G6PD(2), PFKL(1), PFKM(2), PRPS1(1), PRPS1L1(1), PRPS2(2), RPE(1), TALDO1(2), TKTL1(1), TKTL2(3)	14777530	22	22	22	9	0	4	2	9	7	0	0.880	1.000	1.000
382	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), COASY(1), DPYD(1), DPYS(2), ENPP3(1), ILVBL(1), PANK1(2), PANK2(3), PANK3(1), PANK4(1), UPB1(2), VNN1(1)	10603495	17	16	17	7	1	3	4	6	3	0	0.801	1.000	1.000
383	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(2), CD44(1), SPN(1), TGFB2(2), TNFRSF1A(1), TNFSF8(1)	8078902	8	8	8	5	2	3	0	2	1	0	0.875	1.000	1.000
384	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	EPHB1(1), FYN(1), ITGA1(3), ITGB1(3), L1CAM(4), SELP(1)	9750850	13	13	13	8	2	2	1	6	2	0	0.963	1.000	1.000
385	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(5), ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2), ALDH3B1(1), ALDH3B2(2), AOC2(3), AOC3(1), AOX1(7), DBH(2), DCT(4), DDC(2), GOT1(3), GOT2(2), HGD(1), MAOA(1), TH(1), TPO(3), TYR(3)	19435512	47	41	46	12	3	5	8	20	11	0	0.533	1.000	1.000
386	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(1), ALG5(1), B4GALT3(1), B4GALT5(1), DPAGT1(2), DPM1(1), MAN1A1(2), MGAT4A(2), MGAT4B(1), MGAT5(2), RPN1(2), RPN2(1)	11842267	17	17	17	9	0	4	0	9	4	0	0.951	1.000	1.000
387	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	31	ADRA1A(1), ADRB2(2), CHRM2(2), CHRM3(2), CHRM5(2), DRD1(1), DRD2(1), DRD3(2), DRD5(1), HRH2(1), HTR1A(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(1)	15295241	26	25	26	8	4	3	2	13	4	0	0.559	1.000	1.000
388	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	AKT1(2), BDKRB2(1), CALM2(1), CHRNA1(3), FLT1(4), FLT4(6), KDR(5), NOS3(2), PDE2A(1), PDE3A(4), PDE3B(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PRKG1(2), PRKG2(2), RYR2(10), SLC7A1(1), SYT1(1), TNNI1(1)	25547675	56	52	56	12	11	8	6	25	6	0	0.117	1.000	1.000
389	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	62	AKT1(2), AKT2(3), AKT3(2), CDC42(1), CDK2(2), CDKN2A(5), ERBB4(6), F2RL2(1), GAB1(1), GRB2(1), GSK3A(2), INPPL1(2), IRS1(3), IRS4(1), MET(3), MYC(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PARD3(2), PARD6A(2), PDK1(1), PIK3CA(12), PPP1R13B(3), PREX1(6), PTEN(20), PTK2(1), PTPN1(1), RPS6KA1(2), RPS6KB1(1), SHC1(2), SLC2A4(1), SOS1(6), SOS2(1), TSC1(2), TSC2(5), YWHAE(1)	46422402	113	98	109	21	8	18	9	48	29	1	0.0646	1.000	1.000
390	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADM(1), ACADS(2), ACSL3(1), ACSL4(1), CPT1A(1), EHHADH(3), HADHA(1), PECR(1), SCP2(2)	10425285	13	13	12	5	2	4	2	3	2	0	0.624	1.000	1.000
391	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(5), AGXT(1), AGXT2(1), ALAS1(4), ALAS2(3), AOC2(3), AOC3(1), BHMT(1), CHDH(2), CHKB(1), CTH(1), DAO(1), DLD(2), DMGDH(4), GATM(2), GLDC(1), MAOA(1), PISD(1), PLCB2(2), PLCG2(1), SARDH(2), SARS(3), SHMT1(2), SHMT2(3), TARS(2)	26059364	50	47	49	10	3	7	12	22	6	0	0.123	1.000	1.000
392	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(1), CREBBP(4), EP300(6), MAP2K3(9), MAP2K6(1), MAP3K14(1), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(1), TGFBR2(1), TLR2(2)	18349352	29	28	25	7	4	3	4	14	4	0	0.468	1.000	1.000
393	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(2), ABCC2(1), BCHE(2), CES1(2), CES2(2), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2)	14211148	17	15	17	5	1	3	3	5	5	0	0.688	1.000	1.000
394	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	ELK1(1), GRB2(1), HRAS(1), IL2RA(2), IL2RB(1), JAK1(4), JAK3(4), JUN(2), MAPK3(1), SHC1(2), SOS1(6), STAT5B(1), SYK(1)	14274671	27	26	27	9	3	4	2	13	5	0	0.743	1.000	1.000
395	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1R(5), DDX20(4), E2F1(1), HRAS(1), JUN(2), NCOR2(4), RBL2(2), SIN3A(2), SIN3B(1)	16312283	22	22	22	6	0	3	3	12	4	0	0.492	1.000	1.000
396	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(2), ATF2(1), CDC42(1), DLD(2), DUSP10(1), DUSP4(1), DUSP8(1), GAB1(1), IL1R1(1), JUN(2), MAP2K5(2), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K11(1), MAP3K12(3), MAP3K13(1), MAP3K2(2), MAP3K4(5), MAP3K5(5), MAP3K7(1), MAP3K9(1), MAPK10(1), MAPK9(2), NFATC3(3), NR2C2(1), PAPPA(1), SHC1(2), TP53(10), TRAF6(1), ZAK(1)	30785255	65	59	64	12	6	5	11	31	12	0	0.115	1.000	1.000
397	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ALDH18A1(1), ARG1(1), ASL(1), CPS1(6), GATM(2), ODC1(1), OTC(1), PYCR1(1), SMS(2)	10815043	16	16	16	7	0	1	3	10	2	0	0.917	1.000	1.000
398	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), HRAS(1), JUN(2), MAPK3(1), MYC(1), NFKB1(1), PLCB1(1), RELA(1)	9302000	10	10	10	5	3	2	0	4	1	0	0.787	1.000	1.000
399	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(15), ATR(5), BRCA1(6), BRCA2(8), CHEK2(3), FANCA(4), FANCD2(2), FANCE(2), FANCF(2), FANCG(3), HUS1(2), RAD17(1), RAD50(4), RAD51(2), TP53(10), TREX1(1)	27398816	70	58	68	13	4	11	11	31	13	0	0.135	1.000	1.000
400	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(4), EP300(6), MAPK3(1), PELP1(1), SRC(2)	9176202	14	14	14	5	1	3	4	5	1	0	0.666	1.000	1.000
401	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	34	ACTG1(2), ACTR2(1), AKT1(2), CDC42(1), CFL1(1), FLNA(3), FLNC(4), FSCN1(3), MYH2(7), MYLK(4), MYLK2(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PFN2(1), RHO(1), ROCK1(4), ROCK2(3), WASL(6)	28974920	52	46	52	10	3	12	3	22	12	0	0.136	1.000	1.000
402	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(1), CASP10(3), CASP7(1), CFLAR(1), DAXX(4), JUN(2), LMNB1(1), MAP3K1(5), MAP3K7(1), PAK1(1), PRKDC(7), PTPN13(7), RB1(1), RIPK2(1), SPTAN1(5)	26303460	41	36	40	8	2	4	4	21	10	0	0.323	1.000	1.000
403	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), BAAT(1), HADHB(2), SOAT2(3)	14365999	19	18	18	8	1	2	2	10	4	0	0.942	1.000	1.000
404	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(1), CPOX(1), EPRS(2), FECH(2), GUSB(6), HCCS(1), HMOX1(2), HMOX2(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2)	16974408	27	24	25	8	2	4	4	12	5	0	0.625	1.000	1.000
405	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(1), GOSR1(1), SNAP23(1), STX10(1), STX16(1), STX19(1), STX2(1), STX4(1), STX7(2), STX8(1), TSNARE1(2)	10379706	13	12	13	6	1	2	1	8	1	0	0.797	1.000	1.000
406	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(4), ACACB(3), FASN(3), OXSM(1)	9684314	11	11	11	5	1	0	4	5	1	0	0.827	1.000	1.000
407	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	ABAT(1), ACADS(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ECHS1(2), EHHADH(3), GAD2(1), HADHA(1), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(1), PDHB(1), SDHB(1)	15916381	23	22	22	8	4	3	4	7	5	0	0.676	1.000	1.000
408	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(1), AGT(1), EDNRB(1), EGF(4), EGFR(7), HRAS(1), JUN(2), MYC(1), NFKB1(1), RELA(1)	12588662	20	20	19	8	1	3	4	9	3	0	0.802	1.000	1.000
409	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(1), ACP2(1), ACP5(2), ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), CYP19A1(2), CYP1A1(1), CYP1A2(3), CYP2A13(2), CYP2B6(1), CYP2C19(1), CYP2D6(1), CYP2E1(1), CYP2J2(2), CYP3A7(1), CYP4B1(3)	17764358	32	29	32	9	4	9	1	15	3	0	0.296	1.000	1.000
410	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	55	ABP1(5), ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), ALDH3B1(1), ALDH3B2(2), AOC2(3), AOC3(1), AOX1(7), DBH(2), DCT(4), DDC(2), ECH1(1), ESCO1(2), ESCO2(1), GOT1(3), GOT2(2), HGD(1), LCMT1(1), LCMT2(3), MAOA(1), MYST3(4), MYST4(4), PNPLA3(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), SH3GLB1(1), TH(1), TPO(3), TYR(3), TYRP1(1)	36430512	74	62	73	15	5	8	13	34	14	0	0.201	1.000	1.000
411	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), AGTR1(1), ATF2(1), CALM2(1), EGFR(7), ELK1(1), GRB2(1), HRAS(1), JUN(2), MAP3K1(5), MAPK3(1), MEF2A(2), MEF2D(1), PAK1(1), PTK2(1), PTK2B(2), RAC1(1), SHC1(2), SOS1(6), SRC(2), SYT1(1)	20918023	41	38	40	10	5	9	6	17	4	0	0.318	1.000	1.000
412	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(2), BRAF(1), DUSP4(1), DUSP9(1), EIF4E(1), GRB2(1), MAPK3(1), MKNK1(1), MKNK2(1), NFKB1(1), RAP1A(1), RPS6KA1(2), SHC1(2), SOS1(6), SOS2(1), TRAF3(1)	18245304	24	24	24	7	3	3	3	13	2	0	0.606	1.000	1.000
413	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(2), AKT2(3), AKT3(2), CCL3(1), CD86(1), CHUK(1), CXCL11(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), IFNAR1(1), IFNB1(2), IKBKE(2), IRAK1(3), IRAK4(1), JUN(2), LBP(1), LY96(1), MAP2K3(9), MAP2K6(1), MAP2K7(1), MAP3K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), NFKB1(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), RAC1(1), RELA(1), RIPK1(1), SPP1(2), STAT1(4), TICAM1(3), TLR1(1), TLR2(2), TLR4(2), TLR5(2), TLR6(1), TLR7(2), TLR8(4), TLR9(1), TRAF3(1), TRAF6(1)	54642634	104	91	96	17	9	21	12	54	8	0	0.00543	1.000	1.000
414	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	BCL2A1(2), CASP1(1), CASP10(3), CASP2(1), CASP7(1), DAXX(4), FAS(1), FASLG(1), IKBKE(2), LTA(1), NFKB1(1), NGFR(1), NTRK1(4), PTPN13(7), RIPK1(1), TNFRSF1A(1), TRADD(1), TRAF3(1), TRAF6(1)	26758848	35	34	35	8	2	5	4	18	6	0	0.398	1.000	1.000
415	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(1), PGAP1(1), PIGB(1), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(1), PIGN(1), PIGO(1), PIGP(1), PIGQ(5), PIGS(1), PIGT(2), PIGU(1), PIGV(1), PIGZ(1)	15100204	24	23	24	9	2	4	4	11	2	1	0.736	1.000	1.000
416	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(1), POLB(1), POLD1(3), POLD3(1), POLE(4), POLE2(1), POLG(2), POLG2(4), POLH(4), POLI(5), POLK(2), POLL(2), POLM(1), POLQ(5), PRIM1(2), PRIM2(5), REV1(1), REV3L(2), RFC5(1)	25562950	47	44	45	10	4	3	4	21	12	3	0.485	1.000	1.000
417	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	ARHGDIB(1), BIRC2(3), BIRC3(2), CASP1(1), CASP10(3), CASP2(1), CASP7(1), LMNB1(1), PRF1(1)	11766669	14	14	14	5	0	4	2	7	1	0	0.724	1.000	1.000
418	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AASDH(3), AASDHPPT(2), AASS(4), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), BBOX1(2), DLST(1), DOT1L(2), ECHS1(2), EHHADH(3), EHMT1(1), EHMT2(3), HADHA(1), PLOD1(1), PLOD2(4), PLOD3(2), SHMT1(2), SHMT2(3), TMLHE(1)	21926674	44	39	44	11	4	8	4	16	12	0	0.356	1.000	1.000
419	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(7), ELK1(1), GNAS(4), GNB1(2), GRB2(1), HRAS(1), ITGB1(3), KLK2(1), MAPK3(1), MKNK1(1), MKNK2(1), MYC(1), NGFR(1), PDGFRA(7), PPP2CA(1), PTPRR(3), RPS6KA1(2), SHC1(2), SOS1(6), SRC(2), STAT3(1)	20205250	50	47	49	13	4	10	6	25	5	0	0.342	1.000	1.000
420	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	39	ARNTL(1), BTG1(2), CBX3(1), CLOCK(1), EIF4G2(3), ETV6(1), HERPUD1(1), HSPA8(6), IDI1(1), KLF9(2), MYF6(2), NCKAP1(1), NCOA4(3), NR1D2(1), PER1(4), PER2(3), PPP1R3C(1), PPP2CB(1), PSMA4(2), SF3A3(2), TOB1(2), TUBB3(3), UGP2(1), ZFR(7)	22468697	52	46	52	12	1	8	10	19	13	1	0.270	1.000	1.000
421	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	33	AKT1(2), CBL(1), CFLAR(1), E2F1(1), GRB2(1), HRAS(1), IL2RA(2), IL2RB(1), IRS1(3), JAK1(4), JAK3(4), MAPK3(1), MYC(1), PIK3CA(12), PIK3R1(2), PTPN6(3), RPS6KB1(1), SHC1(2), SOS1(6), STAT5B(1), SYK(1)	21772478	51	49	48	13	4	13	6	19	9	0	0.241	1.000	1.000
422	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(1), BAG4(1), CASP2(1), JUN(2), LMNB1(1), MADD(4), MAP3K1(5), MAP3K7(1), PAK1(1), PRKDC(7), RB1(1), RIPK1(1), SPTAN1(5), TNFRSF1A(1), TRADD(1)	24293467	33	32	32	8	1	6	4	13	9	0	0.466	1.000	1.000
423	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(2), ALOX5(2), CYP1A2(3), CYP2C19(1), CYP2E1(1), CYP2J2(2), CYP3A7(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), RDH11(3)	14822445	19	19	19	8	3	2	2	10	2	0	0.754	1.000	1.000
424	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC2(3), BIRC3(2), CFLAR(1), JUN(2), MAP3K7(1), NFKB1(1), NFKBIB(1), NFKBIL1(1), NR2C2(1), RALBP1(1), RIPK1(1), TNFRSF1A(1), TRADD(1)	16105509	18	18	18	8	0	5	3	7	3	0	0.803	1.000	1.000
425	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(7), LCAT(1), LDLR(1), LIPC(1), LPL(1), LRP1(10), SCARB1(2)	16773628	23	23	23	8	2	4	3	10	4	0	0.761	1.000	1.000
426	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAD8(1), ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), AKR1B10(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), BAAT(1), HADHB(2), RDH11(3), SLC27A5(2), SOAT2(3)	19572845	27	26	26	9	3	3	2	14	5	0	0.767	1.000	1.000
427	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	BID(1), BIRC2(3), BIRC3(2), CASP10(3), CASP7(1), CFLAR(1), CHUK(1), GAS2(2), MAP3K14(1), NFKB1(1), RELA(1), RIPK1(1), SPTAN1(5), TNFSF10(1), TRADD(1)	20635809	25	24	25	8	1	4	3	11	6	0	0.711	1.000	1.000
428	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(6), CALM2(1), EP300(6), HDAC1(2), MEF2D(1), NFATC1(1), NFATC2(1), PPP3CA(1), PPP3CC(1), SYT1(1)	14635976	21	20	21	8	3	2	3	11	2	0	0.764	1.000	1.000
429	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	ELK1(1), GRB2(1), HRAS(1), JAK2(5), JUN(2), MAPK3(1), PTPN6(3), SHC1(2), SOS1(6), STAT5B(1)	13158828	23	22	23	8	2	4	3	12	2	0	0.729	1.000	1.000
430	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(2), AKT2(3), AKT3(2), ARHGEF11(3), CDC42(1), DLG4(1), GNA13(4), LPA(2), MAP3K1(5), MAP3K5(5), NFKB1(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(1), PLD1(2), PLD2(2), PLD3(3), PTK2(1), RDX(1), ROCK1(4), ROCK2(3), SRF(1), TBXA2R(1)	30052384	54	49	54	11	2	6	6	28	12	0	0.239	1.000	1.000
431	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(2), AKT2(3), AKT3(2), BCR(1), BTK(1), CD19(1), CSK(2), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(2), NFAT5(7), NFKB1(1), NFKBIB(1), NFKBIL1(1), PIK3CA(12), PIK3R1(2), PLCG2(1), PPP1R13B(3), SHC1(2), SOS1(6), SOS2(1), SYK(1), VAV1(2)	31896980	57	49	53	12	4	16	6	24	7	0	0.0641	1.000	1.000
432	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(1), CARS(4), DARS(1), EPRS(2), HARS(1), IARS(4), KARS(1), LARS(3), LARS2(1), MARS(2), MARS2(3), SARS(3), TARS(2), WARS2(1), YARS(1)	19909360	30	28	29	9	0	4	5	16	5	0	0.659	1.000	1.000
433	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	ANKHD1(3), EEF1A2(1), EEF1D(1), EEF1G(1), EIF2AK1(2), EIF2AK2(4), EIF2AK3(2), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF2S2(1), EIF2S3(1), EIF4A2(3), EIF4E(1), EIF4G1(2), EIF4G3(3), EIF5(2), EIF5A(2), ETF1(3), KIAA0664(3), PABPC1(20), PABPC3(11), PAIP1(2), SLC35A4(2)	27332007	75	66	67	19	7	14	9	27	18	0	0.342	1.000	1.000
434	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	DOCK1(1), ELK1(1), GAB1(1), GRB2(1), HGF(1), HRAS(1), ITGA1(3), ITGB1(3), JUN(2), MAP4K1(1), MAPK3(1), MET(3), PAK1(1), PIK3CA(12), PIK3R1(2), PTEN(20), PTK2(1), PTK2B(2), PTPN11(1), RAP1A(1), RASA1(3), SOS1(6), SRC(2), STAT3(1)	27908220	71	62	68	18	3	18	4	24	21	1	0.416	1.000	1.000
435	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(4), CANT1(1), CTPS(1), DCTD(1), DPYD(1), DPYS(2), NT5M(2), POLB(1), POLD1(3), POLE(4), POLG(2), POLL(2), POLQ(5), POLR1B(2), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLRMT(1), RRM1(2), RRM2(1), TK1(1), TK2(1), UCK1(1), UCK2(1), UMPS(1), UNG(1), UPB1(2)	35180639	55	52	55	11	2	10	11	19	13	0	0.0717	1.000	1.000
436	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	AKT1(2), APC(6), ASAH1(1), DLG4(1), EPHB2(1), GNAI1(1), ITPR1(2), ITPR2(8), ITPR3(3), KCNJ3(3), PITX2(1), RAC1(1), RHO(1), RYR1(11)	28105820	42	39	42	10	7	6	6	19	4	0	0.182	1.000	1.000
437	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	BFAR(1), BTK(1), CAD(4), CASP10(3), CASP8AP2(4), CD7(3), CSNK1A1(1), DAXX(4), DEDD(2), EGFR(7), EPHB2(1), FAIM2(1), MAP2K7(1), MAP3K1(5), MAP3K5(5), MAPK10(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MET(3), NFAT5(7), NFKB1(1), NFKBIB(1), NFKBIL1(1), PFN2(1), PTPN13(7), RALBP1(1), RIPK1(1), ROCK1(4), SMPD1(1), TP53(10), TPX2(1)	45034795	89	75	87	18	8	8	9	44	19	1	0.152	1.000	1.000
438	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(2), AKT2(3), AKT3(2), ANKRD6(2), APC(6), AXIN1(2), AXIN2(1), CER1(1), CSNK1A1(1), CTNNB1(1), DACT1(1), DKK2(1), DVL1(1), FSTL1(1), GSK3A(2), LRP1(10), MVP(3), NKD1(2), NKD2(1), PTPRA(1), SFRP1(2), WIF1(1)	24960163	47	45	46	12	4	8	7	21	7	0	0.375	1.000	1.000
439	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(2), ATF1(2), CDC42(1), DUSP10(1), EIF4E(1), ELK1(1), IL1R1(1), MAP2K3(9), MAP2K6(1), MAP3K10(3), MAP3K4(5), MAP3K5(5), MAP3K7(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPKAPK2(2), MAPKAPK5(1), MKNK1(1), MKNK2(1), NFKB1(1), NR2C2(1), SRF(1), TRAF6(1)	20630113	45	40	40	13	5	6	0	26	8	0	0.599	1.000	1.000
440	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(3), BDKRB1(1), BDKRB2(1), C1QA(1), C1R(3), C1S(1), C2(1), C3(6), C3AR1(1), C4BPA(2), C5(4), C7(2), C8B(2), C8G(1), CD55(1), CFB(1), CFH(5), CR1(7), CR2(1), F11(1), F12(3), F13B(2), F2(3), F5(4), F7(1), F8(3), F9(1), FGA(1), FGG(1), KLKB1(1), KNG1(2), MASP1(1), MASP2(1), MBL2(1), PLAT(2), PLAU(4), PLAUR(3), PLG(5), PROC(4), PROS1(4), SERPINA1(2), SERPINF2(2), SERPING1(2), TFPI(1), VWF(6)	55525696	105	93	105	21	8	17	9	54	17	0	0.0747	1.000	1.000
441	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(9), B3GALT4(1), FAU(1), IL6ST(3), PIGK(1), RPL11(1), RPL18(2), RPL18A(1), RPL19(1), RPL22(2), RPL27(2), RPL28(1), RPL3(1), RPL30(2), RPL31(1), RPL34(1), RPL3L(1), RPL4(2), RPL5(3), RPL7(1), RPLP0(1), RPS11(1), RPS13(1), RPS2(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS27A(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS6KA1(2), RPS6KA6(1), RPS6KB1(1), RPS6KB2(1), SLC36A2(1), TSPAN9(1), UBC(2)	32558147	61	56	60	13	5	5	15	25	11	0	0.140	1.000	1.000
442	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	51	ALG6(1), CCKBR(2), CCR5(3), CELSR1(7), CELSR2(6), CELSR3(4), CHRM2(2), CHRM3(2), CIDEB(1), EMR2(2), EMR3(5), GPR116(3), GPR133(2), GPR17(1), GPR61(1), GPR77(1), GPR84(2), GRM1(4), HRH4(1), LGR6(2), LPHN2(2), LPHN3(7), NTSR1(1), OR8G1(2), OR8G2(2), P2RY11(1), P2RY13(1), PTGFR(2), SMO(3)	39661521	73	60	71	16	9	14	6	33	11	0	0.0725	1.000	1.000
443	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(9), DIAPH1(1), FYN(1), GSN(1), HRAS(1), ITGA1(3), ITGB1(3), MAPK3(1), MYL2(1), MYLK(4), PIK3CA(12), PIK3R1(2), PTK2(1), ROCK1(4), SHC1(2), SRC(2), TLN1(4)	23047889	52	49	47	14	4	14	6	19	8	1	0.366	1.000	1.000
444	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(2), ASAH1(1), ATF1(2), BRAF(1), CREBBP(4), EGR1(2), EGR2(1), EGR3(1), ELK1(1), FRS2(2), JUN(2), MAP1B(3), MAP2K7(1), MAPK10(1), MAPK3(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), NTRK1(4), PIK3C2G(2), PIK3CA(12), PIK3R1(2), PTPN11(1), SHC1(2), SRC(2), TH(1)	31430907	57	51	54	15	6	14	5	24	8	0	0.259	1.000	1.000
445	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(1), BRAF(1), CHUK(1), DAXX(4), ELK1(1), GRB2(1), HRAS(1), JUN(2), MAP2K3(9), MAP2K5(2), MAP2K6(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K11(1), MAP3K12(3), MAP3K13(1), MAP3K14(1), MAP3K2(2), MAP3K4(5), MAP3K5(5), MAP3K6(2), MAP3K7(1), MAP3K9(1), MAP4K1(1), MAP4K2(1), MAP4K3(4), MAP4K4(1), MAP4K5(4), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(1), MAPK9(2), MAPKAPK2(2), MAPKAPK5(1), MAX(3), MEF2A(2), MEF2D(1), MKNK1(1), MKNK2(1), MYC(1), NFKB1(1), PAK1(1), RAC1(1), RELA(1), RIPK1(1), RPS6KA1(2), RPS6KB1(1), RPS6KB2(1), SHC1(2), STAT1(4), TGFB2(2), TGFB3(1), TRADD(1)	59454728	105	89	99	20	14	10	8	50	23	0	0.0871	1.000	1.000
446	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F11(1), F12(3), F13B(2), F2(3), F5(4), F7(1), F8(3), F9(1), FGA(1), FGG(1), LPA(2), PLAT(2), PLAU(4), PLG(5), SERPINF2(2), VWF(6)	21610381	41	41	41	12	2	3	8	19	9	0	0.551	1.000	1.000
447	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(2), AKT2(3), AKT3(2), ASAH1(1), BRAF(1), DRD2(1), EGFR(7), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(8), ITPR3(3), KCNJ3(3), PIK3CB(1), PITX2(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), SHC1(2), SOS1(6), SOS2(1), SRC(2), STAT3(1)	36079091	60	53	59	14	7	11	8	28	6	0	0.136	1.000	1.000
448	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(1), IMPA2(2), INPP4A(2), INPP4B(2), INPP5A(1), INPP5B(2), INPP5E(2), INPPL1(2), ITPKA(1), ITPKB(2), MIOX(2), OCRL(1), PI4KA(8), PI4KB(1), PIK3C3(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIP4K2A(1), PIP5K1A(2), PIP5K1C(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLCD3(1), PLCD4(3), PLCE1(3), PLCG2(1), PTEN(20), PTPMT1(1), SYNJ1(4), SYNJ2(5)	45816746	97	84	93	22	5	15	8	34	34	1	0.285	1.000	1.000
449	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), F2(3), FYN(1), GNAI1(1), GNB1(2), GRB2(1), HRAS(1), JAK2(5), MAPK14(1), MAPK3(1), MAPT(1), MYLK(4), PTK2B(2), SHC1(2), SOS1(6), STAT1(4), STAT3(1), SYT1(1)	25864845	44	41	44	12	4	6	6	23	5	0	0.464	1.000	1.000
450	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(2), AKT2(3), AKT3(2), BCR(1), BTK(1), CD19(1), CD22(1), CR2(1), CSK(2), GRB2(1), GSK3A(2), INPP5D(1), ITPR1(2), ITPR2(8), ITPR3(3), MAP4K1(1), MAPK3(1), NFATC1(1), NFATC2(1), PDK1(1), PIK3CA(12), PIK3R1(2), PLCG2(1), PPP1R13B(3), PPP3CA(1), PPP3CC(1), PTPRC(6), SHC1(2), SOS1(6), SOS2(1), SYK(1), VAV1(2)	45144059	74	64	71	16	6	18	8	32	10	0	0.0522	1.000	1.000
451	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(2), AKT2(3), AKT3(2), BCL10(1), BTK(1), CARD11(4), CD19(1), CD22(1), CHUK(1), CR2(1), HRAS(1), INPP5D(1), JUN(2), KRAS(1), LILRB3(4), MALT1(2), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NFKB1(1), NFKBIB(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PTPN6(3), RAC1(1), RAC3(1), RASGRP3(1), SYK(1), VAV1(2), VAV2(4)	45555185	86	80	81	20	2	19	11	42	12	0	0.180	1.000	1.000
452	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	24	GHR(1), GRB2(1), HRAS(1), INSR(3), IRS1(3), JAK2(5), MAPK3(1), PIK3CA(12), PIK3R1(2), PTPN6(3), RPS6KA1(2), SHC1(2), SLC2A4(1), SOS1(6), SRF(1), STAT5B(1)	20117940	45	42	42	13	4	11	7	20	3	0	0.340	1.000	1.000
453	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(1), ARHGAP1(1), ARHGAP5(9), ARHGAP6(1), ARHGEF1(1), ARHGEF11(3), ARHGEF5(3), ARPC1B(1), ARPC2(1), CFL1(1), DIAPH1(1), GSN(1), MYL2(1), MYLK(4), OPHN1(1), PIP5K1A(2), ROCK1(4), SRC(2), TLN1(4), VCL(2)	28107592	44	41	41	11	1	8	6	19	9	1	0.385	1.000	1.000
454	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(1), CPEB1(3), EGFR(7), ERBB2(4), ERBB4(6), ETV6(1), FMN2(13), GRB2(1), KRAS(1), MAPK3(1), NOTCH1(5), NOTCH2(9), NOTCH3(6), NOTCH4(1), PIWIL1(2), PIWIL2(2), PIWIL3(3), PIWIL4(1), SOS1(6), SOS2(1), SPIRE1(1), SPIRE2(2)	30577295	77	71	73	21	8	9	8	34	18	0	0.657	1.000	1.000
455	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(1), AARS2(1), ABAT(1), ADSL(1), ADSSL1(1), AGXT(1), AGXT2(1), ASL(1), ASNS(1), ASPA(1), ASS1(2), CAD(4), CRAT(1), DARS(1), DLAT(2), DLD(2), GAD2(1), GOT1(3), GOT2(2), GPT(1), GPT2(1), NARS2(4), PC(1), PDHA1(1), PDHA2(1), PDHB(1)	23391226	38	32	38	11	2	2	9	12	13	0	0.573	1.000	1.000
456	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(1), COL4A2(1), COL4A3(4), COL4A4(1), COL4A5(7), COL4A6(4), F11(1), F12(3), F2(3), F5(4), F8(3), F9(1), FGA(1), FGG(1), KLKB1(1), PROC(4), PROS1(4), SERPING1(2)	27873892	46	43	46	14	4	12	3	19	8	0	0.478	1.000	1.000
457	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACADM(1), ACADS(2), ACOX1(1), ACOX3(2), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(4), ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), CPT1A(1), CYP4A11(4), CYP4A22(1), ECHS1(2), EHHADH(3), HADH(1), HADHA(1), HADHB(2), HSD17B4(1), PECI(1)	30408563	43	43	41	12	5	6	8	16	8	0	0.410	1.000	1.000
458	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(1), CAD(4), CANT1(1), CTPS(1), DCTD(1), DPYD(1), DPYS(2), NT5C1B(1), NT5C2(1), NT5C3(1), NT5M(2), POLA1(1), POLD1(3), POLD3(1), POLE(4), POLE2(1), POLR1A(3), POLR1B(2), POLR1C(3), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLR3A(4), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(5), RFC5(1), RRM1(2), RRM2(1), TK1(1), TK2(1), TXNRD2(1), UCK1(1), UCK2(1), UMPS(1), UPB1(2), UPP2(2), UPRT(1)	50635943	80	71	76	18	2	17	13	28	17	3	0.0958	1.000	1.000
459	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(1), ADC(1), ALDH4A1(1), CAD(4), CPS1(6), EPRS(2), GAD2(1), GFPT1(1), GFPT2(1), GLS(4), GLS2(2), GOT1(3), GOT2(2), GPT(1), GPT2(1), GSR(1), GSS(1), NAGK(2)	24484622	35	31	35	10	2	4	7	15	7	0	0.574	1.000	1.000
460	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(1), AKT1(2), GCA(1), ITGA9(1), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(8), ITPR3(3), MAPK3(1), NR1I3(1), PAK1(1), PDE3A(4), PDE3B(1), PIK3C2G(2), PIK3CA(12), PIK3R1(2)	30345000	45	40	42	12	4	11	5	19	6	0	0.239	1.000	1.000
461	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), AGK(5), AGPAT6(1), AKR1B1(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), DAK(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), GK2(1), GLB1(4), GPAM(1), LCT(2), LIPC(1), LIPF(1), LPL(1), PNLIP(3), PNLIPRP2(1), PNPLA3(2), PPAP2B(1), PPAP2C(2)	36385524	50	46	49	13	5	8	8	19	10	0	0.372	1.000	1.000
462	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAS1(4), ALAS2(3), BLVRA(1), COX15(1), CPOX(1), EPRS(2), FECH(2), FTMT(2), GUSB(6), HCCS(1), HMOX1(2), HMOX2(1), MMAB(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B10(1), UGT2B11(2), UGT2B15(1), UGT2B28(1), UGT2B4(2), UGT2B7(2)	26178342	49	45	46	14	3	7	7	25	7	0	0.517	1.000	1.000
463	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTG1(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(1), AKT1(2), AKT2(3), AKT3(2), ARHGAP5(9), BCAR1(3), BIRC2(3), BIRC3(2), BRAF(1), CCND2(1), CDC42(1), CHAD(2), COL11A1(9), COL11A2(2), COL1A1(1), COL1A2(6), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(1), COL4A6(4), COL5A1(3), COL5A2(4), COL5A3(11), COL6A1(2), COL6A2(5), COL6A3(9), COL6A6(12), CTNNB1(1), DIAPH1(1), DOCK1(1), EGF(4), EGFR(7), ELK1(1), ERBB2(4), FARP2(2), FIGF(3), FLNA(3), FLNB(2), FLNC(4), FLT1(4), FN1(4), FYN(1), GRB2(1), GRLF1(6), HGF(1), HRAS(1), IBSP(1), ILK(1), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(1), ITGA9(1), ITGB1(3), ITGB3(1), ITGB4(1), ITGB5(3), ITGB6(2), ITGB7(2), ITGB8(1), JUN(2), KDR(5), LAMA1(7), LAMA2(6), LAMA3(6), LAMA4(5), LAMA5(5), LAMB1(2), LAMB2(3), LAMB3(1), LAMB4(4), LAMC1(3), LAMC2(5), LAMC3(4), MAPK10(1), MAPK3(1), MAPK9(2), MET(3), MYL2(1), MYL7(1), MYL9(1), MYLK(4), MYLK2(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PARVG(1), PDGFC(1), PDGFD(1), PDGFRA(7), PDGFRB(1), PGF(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP5K1C(2), PPP1R12A(1), PRKCG(1), PTEN(20), PTK2(1), RAC1(1), RAC3(1), RAP1A(1), RAPGEF1(2), RELN(3), ROCK1(4), ROCK2(3), SHC1(2), SHC2(1), SHC3(1), SOS1(6), SOS2(1), SPP1(2), SRC(2), THBS1(6), THBS2(1), THBS3(6), THBS4(3), TLN1(4), TLN2(6), TNC(5), TNN(3), TNR(8), TNXB(2), VAV1(2), VAV2(4), VCL(2), VTN(1), VWF(6), ZYX(1)	227635775	431	254	423	142	39	67	52	179	92	2	0.818	1.000	1.000
464	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	246	ACVR1B(4), ACVR1C(1), AKT1(2), AKT2(3), AKT3(2), ATF2(1), ATF4(2), BRAF(1), CACNA1A(5), CACNA1B(4), CACNA1C(8), CACNA1D(4), CACNA1E(2), CACNA1F(3), CACNA1G(7), CACNA1H(3), CACNA1I(4), CACNA1S(7), CACNA2D1(3), CACNA2D2(1), CACNA2D4(3), CACNB1(1), CACNB2(1), CACNG3(2), CACNG5(2), CACNG6(1), CACNG7(1), CACNG8(1), CDC42(1), CHUK(1), DAXX(4), DUSP10(1), DUSP3(1), DUSP4(1), DUSP5(2), DUSP8(1), DUSP9(1), ECSIT(2), EGF(4), EGFR(7), ELK1(1), ELK4(1), FAS(1), FASLG(1), FGF13(1), FGF14(1), FGF19(1), FGF2(1), FGF20(1), FGF3(1), FGF6(1), FGF7(1), FGFR1(4), FGFR2(3), FGFR3(6), FGFR4(3), FLNA(3), FLNB(2), FLNC(4), GNG12(1), GRB2(1), HRAS(1), IL1R1(1), JUN(2), KRAS(1), MAP2K3(9), MAP2K5(2), MAP2K6(1), MAP2K7(1), MAP3K1(5), MAP3K10(3), MAP3K12(3), MAP3K13(1), MAP3K14(1), MAP3K2(2), MAP3K4(5), MAP3K5(5), MAP3K6(2), MAP3K7(1), MAP4K1(1), MAP4K2(1), MAP4K3(4), MAP4K4(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MAPKAPK2(2), MAPKAPK5(1), MAPT(1), MAX(3), MKNK1(1), MKNK2(1), MRAS(1), MYC(1), NF1(7), NFATC2(1), NFATC4(4), NFKB1(1), NR4A1(1), NTRK1(4), PAK1(1), PDGFRA(7), PDGFRB(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PPM1B(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PPP5C(2), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), PTPN5(2), PTPN7(1), PTPRR(3), RAC1(1), RAC3(1), RAP1A(1), RAPGEF2(6), RASA1(3), RASA2(1), RASGRF1(3), RASGRF2(2), RASGRP2(2), RASGRP3(1), RASGRP4(2), RPS6KA1(2), RPS6KA6(1), SOS1(6), SOS2(1), SRF(1), TAOK2(3), TGFB2(2), TGFB3(1), TGFBR2(1), TNFRSF1A(1), TP53(10), TRAF6(1), ZAK(1)	178314331	325	223	315	89	32	40	37	149	67	0	0.372	1.000	1.000
465	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(1), ADCY2(3), ADCY3(3), ADCY7(1), ADCY8(6), ADCY9(3), ADORA2A(1), ADORA2B(1), ADRA1A(1), ADRB2(2), AGTR1(1), ATP2A1(6), ATP2A2(4), ATP2B1(1), ATP2B2(1), ATP2B3(1), ATP2B4(1), AVPR1A(1), BDKRB1(1), BDKRB2(1), CACNA1A(5), CACNA1B(4), CACNA1C(8), CACNA1D(4), CACNA1E(2), CACNA1F(3), CACNA1G(7), CACNA1H(3), CACNA1I(4), CACNA1S(7), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CCKAR(2), CCKBR(2), CD38(1), CHRM2(2), CHRM3(2), CHRM5(2), CHRNA7(1), CYSLTR1(1), DRD1(1), EDNRB(1), EGFR(7), ERBB2(4), ERBB3(3), ERBB4(6), GNA15(1), GNAS(4), GRIN1(2), GRIN2A(4), GRM1(4), GRM5(4), HRH2(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(1), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(8), ITPR3(3), MYLK(4), MYLK2(1), NOS1(8), NOS3(2), NTSR1(1), P2RX1(2), P2RX2(3), P2RX3(1), PDE1A(1), PDE1B(2), PDE1C(1), PDGFRA(7), PDGFRB(1), PHKA1(3), PHKA2(3), PHKB(3), PHKG1(3), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLCD3(1), PLCD4(3), PLCE1(3), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), PTAFR(1), PTGFR(2), PTK2B(2), RYR1(11), RYR2(10), RYR3(11), SLC25A4(2), SLC25A5(3), SLC25A6(1), SLC8A1(1), SLC8A2(2), SLC8A3(3), SPHK2(1), TACR1(2), TACR2(1), TACR3(2), TBXA2R(1), TRHR(2), TRPC1(1)	167992818	302	219	299	94	43	39	27	142	51	0	0.497	1.000	1.000
466	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ABI2(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(1), APC(6), APC2(4), ARHGEF1(1), ARHGEF6(1), ARHGEF7(3), ARPC1B(1), ARPC2(1), ARPC5L(1), BCAR1(3), BDKRB1(1), BDKRB2(1), BRAF(1), C3orf10(2), CDC42(1), CFL1(1), CHRM2(2), CHRM3(2), CHRM5(2), CSK(2), CYFIP1(4), CYFIP2(5), DIAPH1(1), DIAPH2(2), DIAPH3(3), DOCK1(1), EGF(4), EGFR(7), F2(3), FGD1(3), FGF13(1), FGF14(1), FGF19(1), FGF2(1), FGF20(1), FGF3(1), FGF6(1), FGF7(1), FGFR1(4), FGFR2(3), FGFR3(6), FGFR4(3), FN1(4), GIT1(2), GNA13(4), GNG12(1), GRLF1(6), GSN(1), HRAS(1), IQGAP1(5), IQGAP2(3), IQGAP3(3), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(1), ITGA9(1), ITGAD(2), ITGAE(3), ITGAL(4), ITGAM(3), ITGAX(2), ITGB1(3), ITGB2(1), ITGB3(1), ITGB4(1), ITGB5(3), ITGB6(2), ITGB7(2), ITGB8(1), KRAS(1), LIMK2(2), MAPK3(1), MRAS(1), MSN(2), MYH14(3), MYH9(2), MYL2(1), MYL7(1), MYL9(1), MYLK(4), MYLK2(1), NCKAP1(1), NCKAP1L(2), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PDGFRA(7), PDGFRB(1), PFN2(1), PFN4(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP4K2A(1), PIP5K1A(2), PIP5K1C(2), PPP1R12A(1), PTK2(1), RAC1(1), RAC3(1), RDX(1), ROCK1(4), ROCK2(3), SCIN(1), SLC9A1(2), SOS1(6), SOS2(1), SSH1(2), SSH2(5), SSH3(1), TIAM1(2), TIAM2(2), VAV1(2), VAV2(4), VCL(2), WASF2(1), WASL(6)	172722076	296	206	287	83	21	43	40	137	55	0	0.401	1.000	1.000
467	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTG1(2), CHAD(2), COL11A1(9), COL11A2(2), COL17A1(3), COL1A1(1), COL1A2(6), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(1), COL4A6(4), COL5A1(3), COL5A2(4), COL5A3(11), COL6A1(2), COL6A2(5), COL6A3(9), COL6A6(12), DSC2(3), DSG1(3), DSG2(2), DSG3(1), DSG4(1), FN1(4), GJA1(2), GJA10(1), GJA3(1), GJA4(1), GJA5(3), GJA8(2), GJA9(1), GJB1(1), GJB3(1), GJB6(2), GJC1(1), GJC2(1), GJD2(1), IBSP(1), ITGA6(4), ITGB4(1), KRT1(7), KRT10(1), KRT12(2), KRT13(3), KRT15(2), KRT16(1), KRT17(1), KRT19(1), KRT2(3), KRT23(1), KRT24(2), KRT27(1), KRT28(1), KRT3(3), KRT31(1), KRT35(1), KRT36(2), KRT38(1), KRT4(4), KRT5(1), KRT6A(1), KRT6B(1), KRT6C(1), KRT7(1), KRT71(2), KRT72(1), KRT73(1), KRT74(1), KRT75(3), KRT77(1), KRT78(1), KRT79(2), KRT82(2), KRT83(1), KRT84(1), KRT85(2), KRT86(1), LAMA1(7), LAMA2(6), LAMA3(6), LAMA4(5), LAMA5(5), LAMB1(2), LAMB2(3), LAMB3(1), LAMB4(4), LAMC1(3), LAMC2(5), LAMC3(4), LMNB1(1), NES(5), PRPH(1), RELN(3), SPP1(2), THBS1(6), THBS2(1), THBS3(6), THBS4(3), TNC(5), TNN(3), TNR(8), TNXB(2), VTN(1), VWF(6)	150895233	289	203	281	110	30	38	31	114	76	0	0.987	1.000	1.000
468	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	235	ADCYAP1R1(2), ADORA2A(1), ADORA2B(1), ADRA1A(1), ADRA2B(2), ADRB2(2), AGTR1(1), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CALCR(1), CCKAR(2), CCKBR(2), CHRM2(2), CHRM3(2), CHRM5(2), CNR1(1), CNR2(1), CRHR2(1), CYSLTR1(1), DRD1(1), DRD2(1), DRD3(2), DRD5(1), EDNRB(1), F2(3), F2RL1(1), F2RL2(1), FPR1(1), GABBR1(1), GABRA1(1), GABRA3(2), GABRA4(2), GABRA5(1), GABRB1(3), GABRB3(1), GABRE(4), GABRG1(2), GABRG2(4), GABRQ(4), GABRR1(2), GALR1(1), GH2(1), GHR(1), GIPR(1), GLP1R(1), GLP2R(2), GLRA2(1), GLRB(1), GPR35(1), GPR50(3), GPR63(1), GPR83(1), GRIA1(4), GRIA2(3), GRIA4(2), GRID1(3), GRID2(4), GRIK1(3), GRIK2(4), GRIK3(2), GRIK5(3), GRIN1(2), GRIN2A(4), GRIN2B(5), GRIN3B(3), GRM1(4), GRM2(2), GRM3(2), GRM4(3), GRM5(4), GRM6(3), GRM7(1), GRM8(2), HCRTR2(1), HRH2(1), HRH4(1), HTR1A(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(1), LEP(1), LEPR(1), MAS1(1), MC2R(2), MC3R(2), MC4R(1), MC5R(1), MCHR2(2), MTNR1B(1), NMBR(1), NMUR2(4), NPBWR1(1), NPBWR2(1), NPFFR2(2), NPY1R(1), NTSR1(1), OPRD1(3), OPRM1(2), P2RX1(2), P2RX2(3), P2RX3(1), P2RY10(1), P2RY11(1), P2RY13(1), P2RY14(1), P2RY2(1), P2RY6(1), P2RY8(3), PARD3(2), PPYR1(2), PRLR(2), PRSS1(3), PRSS3(2), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(2), PTGIR(1), RXFP1(1), SCTR(1), SSTR1(2), SSTR3(1), SSTR4(1), TAAR2(1), TAAR9(1), TACR1(2), TACR2(1), TACR3(2), TBXA2R(1), THRA(2), TRHR(2), VIPR1(1)	133299208	243	181	239	75	37	39	20	108	39	0	0.401	1.000	1.000
469	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(5), CD44(1), CHAD(2), COL11A1(9), COL11A2(2), COL1A1(1), COL1A2(6), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(1), COL4A6(4), COL5A1(3), COL5A2(4), COL5A3(11), COL6A1(2), COL6A2(5), COL6A3(9), COL6A6(12), FN1(4), FNDC1(2), FNDC3A(2), GP6(2), HMMR(1), HSPG2(8), IBSP(1), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(1), ITGA9(1), ITGB1(3), ITGB3(1), ITGB4(1), ITGB5(3), ITGB6(2), ITGB7(2), ITGB8(1), LAMA1(7), LAMA2(6), LAMA3(6), LAMA4(5), LAMA5(5), LAMB1(2), LAMB2(3), LAMB3(1), LAMB4(4), LAMC1(3), LAMC2(5), LAMC3(4), RELN(3), SDC3(1), SPP1(2), SV2C(2), THBS1(6), THBS2(1), THBS3(6), THBS4(3), TNC(5), TNN(3), TNR(8), TNXB(2), VTN(1), VWF(6)	136421267	238	180	236	89	26	32	29	93	58	0	0.959	1.000	1.000
470	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	130	ACTG1(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(1), AKT1(2), AKT2(3), AKT3(2), AMOTL1(1), ASH1L(3), CASK(1), CDC42(1), CDK4(1), CGN(1), CLDN10(2), CLDN16(1), CLDN18(1), CLDN2(2), CLDN4(1), CLDN7(1), CLDN9(1), CSDA(3), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(4), CTNNA3(2), CTNNB1(1), EPB41L1(1), EPB41L2(2), EPB41L3(3), EXOC4(2), F11R(1), GNAI1(1), GNAI2(1), GNAI3(1), HCLS1(1), HRAS(1), INADL(3), KRAS(1), LLGL1(3), LLGL2(2), MAGI1(2), MAGI2(4), MAGI3(4), MLLT4(5), MPDZ(4), MPP5(1), MRAS(1), MYH1(4), MYH11(6), MYH13(4), MYH14(3), MYH15(2), MYH2(7), MYH3(5), MYH4(6), MYH6(3), MYH7(2), MYH7B(4), MYH8(1), MYH9(2), MYL2(1), MYL7(1), MYL9(1), PARD3(2), PARD6A(2), PARD6B(3), PPM1J(2), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), PPP2R3A(1), PPP2R3B(1), PPP2R4(1), PRKCD(2), PRKCE(4), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(3), PRKCZ(2), PTEN(20), SPTAN1(5), SRC(2), TJAP1(1), TJP1(2), TJP2(2), YES1(1), ZAK(1)	120418292	214	160	212	72	20	23	14	86	69	2	0.939	1.000	1.000
471	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY7(1), ADCY8(6), ADCY9(3), ADRA1A(1), ADRB2(2), ANXA6(1), ATP1A4(3), ATP2A2(4), ATP2B1(1), ATP2B2(1), ATP2B3(1), CACNA1A(5), CACNA1B(4), CACNA1C(8), CACNA1D(4), CACNA1E(2), CACNA1S(7), CACNB1(1), CALM2(1), CALR(1), CAMK1(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CASQ1(2), CASQ2(2), CHRM2(2), CHRM3(2), CHRM5(2), GJA1(2), GJA4(1), GJA5(3), GJB1(1), GJB3(1), GJB6(2), GNAI2(1), GNAI3(1), GNAO1(1), GNAZ(1), GNB1(2), GNB5(1), GNG12(1), GNG3(1), GRK5(1), GRK6(3), ITPR1(2), ITPR2(8), ITPR3(3), KCNJ3(3), MYCBP(1), PKIA(1), PLCB3(1), PRKACA(1), PRKACB(4), PRKAR1A(2), PRKAR2B(1), PRKCD(2), PRKCE(4), PRKCG(1), PRKCH(2), PRKCQ(3), PRKCZ(2), PRKD1(3), RGS11(1), RGS17(2), RGS18(1), RGS19(1), RGS2(1), RGS3(5), RGS6(2), RGS7(1), RGS9(3), RYR1(11), RYR2(10), RYR3(11), SLC8A1(1), SLC8A3(3), USP5(1)	118094932	206	158	204	59	29	23	17	93	44	0	0.424	1.000	1.000
472	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1B(4), ACVR2A(1), ACVR2B(1), AMHR2(2), BMP2(1), BMP7(2), BMPR1B(1), BMPR2(4), CCL2(1), CCL27(1), CCL3(1), CCR5(3), CCR6(1), CCR9(1), CD27(1), CLCF1(1), CSF1R(5), CSF2RA(3), CSF2RB(1), CSF3R(2), CXCL11(1), CXCR4(1), CXCR6(1), EDA(1), EGF(4), EGFR(7), FAS(1), FASLG(1), FLT1(4), FLT3(2), FLT4(6), GDF5(1), GH2(1), GHR(1), HGF(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), IFNAR1(1), IFNB1(2), IFNGR1(2), IFNGR2(1), IFNK(1), IL12RB1(1), IL12RB2(2), IL13RA1(1), IL15(1), IL15RA(2), IL17RA(1), IL17RB(1), IL18R1(1), IL18RAP(3), IL19(2), IL1R1(1), IL1RAP(4), IL21(1), IL21R(2), IL22(1), IL22RA1(1), IL23A(1), IL23R(1), IL25(2), IL28A(1), IL28B(2), IL2RA(2), IL2RB(1), IL3(1), IL4(1), IL4R(2), IL6ST(3), IL9R(3), INHBA(2), INHBB(1), INHBC(1), INHBE(1), KDR(5), KIT(3), KITLG(2), LEP(1), LEPR(1), LIFR(2), LTA(1), LTBR(2), MET(3), NGFR(1), OSMR(1), PDGFC(1), PDGFRA(7), PDGFRB(1), PF4(1), PLEKHO2(1), PRLR(2), RELT(1), TGFB2(2), TGFB3(1), TGFBR2(1), TNFRSF13B(1), TNFRSF17(1), TNFRSF1A(1), TNFRSF4(1), TNFRSF9(1), TNFSF10(1), TNFSF14(2), TNFSF15(1), TNFSF8(1), TNFSF9(1), TPO(3), XCL1(2), XCR1(1)	108952487	192	154	189	46	12	32	24	102	22	0	0.0988	1.000	1.000
473	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(4), ABLIM1(3), ABLIM3(2), CDC42(1), CFL1(1), CXCR4(1), DCC(3), DPYSL2(2), EFNA3(1), EPHA1(3), EPHA3(2), EPHA5(3), EPHA6(2), EPHA7(1), EPHA8(5), EPHB1(1), EPHB2(1), EPHB4(3), EPHB6(5), FES(1), FYN(1), GNAI1(1), GNAI2(1), GNAI3(1), HRAS(1), ITGB1(3), KRAS(1), L1CAM(4), LIMK2(2), MAPK3(1), MET(3), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NRP1(1), NTN4(2), NTNG1(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PLXNA1(2), PLXNA2(2), PLXNA3(3), PLXNB1(5), PLXNB2(3), PLXNC1(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PTK2(1), RAC1(1), RAC3(1), RASA1(3), RGS3(5), RND1(3), ROBO1(2), ROBO2(4), ROBO3(1), ROCK1(4), ROCK2(3), SEMA3A(2), SEMA3B(1), SEMA3C(1), SEMA3D(3), SEMA3E(2), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4C(1), SEMA4D(1), SEMA4F(1), SEMA4G(2), SEMA5A(1), SEMA6C(1), SEMA6D(2), SLIT1(1), SLIT2(3), SLIT3(5), SRGAP1(4), SRGAP2(1), SRGAP3(2), UNC5A(2), UNC5B(2), UNC5C(1), UNC5D(2)	119700033	185	146	183	69	17	27	19	86	36	0	0.964	1.000	1.000
474	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	137	ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY7(1), ADCY8(6), ADCY9(3), ATF1(2), ATF2(1), ATF4(2), ATF5(1), ATP2A2(4), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CNN2(1), CORIN(1), DGKZ(2), GABPA(1), GBA2(4), GJA1(2), GNB1(2), GNB5(1), GNG12(1), GNG3(1), GRK5(1), GRK6(3), GSTO1(1), GUCA2A(1), GUCY1A3(2), IGFBP2(1), IGFBP3(1), IGFBP4(1), IGFBP6(1), ITPR1(2), ITPR2(8), ITPR3(3), JUN(2), MYL2(1), MYLK2(1), NFKB1(1), NOS1(8), NOS3(2), PDE4B(2), PDE4D(1), PKIA(1), PLCB3(1), PLCG2(1), PRKACA(1), PRKACB(4), PRKAR1A(2), PRKAR2B(1), PRKCD(2), PRKCE(4), PRKCH(2), PRKCQ(3), PRKCZ(2), PRKD1(3), RAMP1(1), RAMP3(1), RGS11(1), RGS17(2), RGS18(1), RGS19(1), RGS2(1), RGS3(5), RGS6(2), RGS7(1), RGS9(3), RLN1(1), RYR1(11), RYR2(10), RYR3(11), SLC8A1(1), TNXB(2), USP5(1)	106310346	179	145	177	53	23	24	16	82	34	0	0.642	1.000	1.000
475	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	57	ASH1L(3), ASH2L(2), CTCFL(1), DOT1L(2), EHMT1(1), EHMT2(3), EZH1(1), EZH2(3), FBXO11(2), HCFC1(5), HSF4(2), JMJD4(1), JMJD6(4), KDM6A(4), MEN1(1), MLL(5), MLL2(14), MLL3(16), MLL4(4), MLL5(6), NSD1(4), OGT(4), PRDM2(3), PRDM6(1), PRDM7(2), PRDM9(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), RBBP5(3), SETD1A(2), SETD1B(1), SETD2(52), SETDB1(4), SETMAR(1), SUV39H2(3), SUZ12(5), WHSC1(2), WHSC1L1(5)	75331297	178	143	176	39	11	18	22	53	73	1	0.126	1.000	1.000
476	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(6), APC2(4), AXIN1(2), AXIN2(1), BTRC(2), CACYBP(2), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CCND2(1), CER1(1), CHD8(2), CREBBP(4), CSNK1A1(1), CSNK2A2(1), CSNK2B(1), CTBP1(1), CTBP2(1), CTNNB1(1), CUL1(3), CXXC4(1), DAAM1(2), DKK2(1), DVL1(1), EP300(6), FBXW11(1), FZD1(2), FZD10(2), FZD3(1), FZD4(3), FZD5(1), JUN(2), LEF1(1), LRP5(2), LRP6(2), MAP3K7(1), MAPK10(1), MAPK9(2), MMP7(1), MYC(1), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NKD1(2), NKD2(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PORCN(1), PPARD(1), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRICKLE1(2), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), RAC1(1), RAC3(1), ROCK1(4), ROCK2(3), SFRP1(2), SFRP4(4), SMAD2(2), SMAD3(1), SMAD4(1), TBL1X(2), TBL1XR1(3), TCF7(2), TCF7L2(1), TP53(10), VANGL1(1), VANGL2(1), WIF1(1), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(1)	97713874	175	141	170	54	14	15	27	84	35	0	0.738	1.000	1.000
477	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	ALCAM(2), CADM1(1), CADM3(1), CD22(1), CD28(1), CD34(1), CD4(2), CD6(2), CD86(1), CD99(1), CDH1(2), CDH2(5), CDH3(2), CDH4(4), CDH5(1), CLDN10(2), CLDN16(1), CLDN18(1), CLDN2(2), CLDN4(1), CLDN7(1), CLDN9(1), CNTN1(2), CNTN2(1), CNTNAP1(5), CNTNAP2(4), ESAM(1), F11R(1), GLG1(4), HLA-A(4), HLA-B(5), HLA-C(2), HLA-DPA1(1), HLA-DPB1(2), HLA-DQB1(4), HLA-DRA(1), HLA-DRB1(12), HLA-DRB5(8), HLA-E(2), HLA-F(1), ITGA4(1), ITGA6(4), ITGA9(1), ITGAL(4), ITGAM(3), ITGB1(3), ITGB2(1), ITGB7(2), ITGB8(1), L1CAM(4), MADCAM1(4), MPZL1(1), NCAM1(2), NCAM2(2), NEGR1(2), NEO1(2), NFASC(4), NRCAM(3), NRXN1(5), NRXN2(4), NRXN3(3), PTPRC(6), PTPRF(3), PTPRM(3), PVRL2(2), PVRL3(2), SDC3(1), SELE(4), SELP(1), SELPLG(1), SIGLEC1(1), SPN(1), VCAM1(1), VCAN(6)	88453477	184	140	177	80	14	26	28	86	30	0	0.990	1.000	1.000
478	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(4), ACACB(3), AKT1(2), AKT2(3), AKT3(2), BRAF(1), CALM2(1), CBL(1), CBLB(2), CBLC(1), ELK1(1), EXOC7(1), FASN(3), FBP1(1), FOXO1(2), G6PC(2), GRB2(1), GYS1(1), GYS2(1), HRAS(1), INPP5D(1), INSR(3), IRS1(3), IRS4(1), KRAS(1), LIPE(4), MAPK10(1), MAPK3(1), MAPK9(2), MKNK1(1), MKNK2(1), PCK1(4), PCK2(1), PDE3A(4), PDE3B(1), PFKL(1), PFKM(2), PHKA1(3), PHKA2(3), PHKB(3), PHKG1(3), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PKM2(1), PPARGC1A(3), PPP1R3A(3), PPP1R3C(1), PPP1R3D(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKAG1(1), PRKAG2(4), PRKAR1A(2), PRKAR2B(1), PRKCI(1), PRKCZ(2), PTPN1(1), PTPRF(3), PYGB(2), PYGL(1), PYGM(2), RAPGEF1(2), RHEB(4), RHOQ(1), RPS6KB1(1), RPS6KB2(1), SH2B2(1), SHC1(2), SHC2(1), SHC3(1), SLC2A4(1), SOCS4(1), SORBS1(1), SOS1(6), SOS2(1), SREBF1(2), TRIP10(1), TSC1(2), TSC2(5)	97539146	171	138	165	31	14	29	21	85	22	0	0.00404	1.000	1.000
479	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	150	AKT1(2), AKT2(3), AKT3(2), CBL(1), CBLB(2), CBLC(1), CCND2(1), CLCF1(1), CREBBP(4), CSF2RA(3), CSF2RB(1), CSF3R(2), EP300(6), GH2(1), GHR(1), GRB2(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), IFNAR1(1), IFNB1(2), IFNGR1(2), IFNGR2(1), IFNK(1), IL12RB1(1), IL12RB2(2), IL13RA1(1), IL15(1), IL15RA(2), IL19(2), IL21(1), IL21R(2), IL22(1), IL22RA1(1), IL23A(1), IL23R(1), IL28A(1), IL28B(2), IL2RA(2), IL2RB(1), IL3(1), IL4(1), IL4R(2), IL6ST(3), IL9R(3), IRF9(2), JAK1(4), JAK2(5), JAK3(4), LEP(1), LEPR(1), LIFR(2), MYC(1), OSMR(1), PIAS1(2), PIAS2(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PRLR(2), PTPN11(1), PTPN6(3), SOCS4(1), SOS1(6), SOS2(1), SPRED1(5), SPRED2(1), SPRY2(2), SPRY4(2), STAM(2), STAT1(4), STAT2(3), STAT3(1), STAT4(1), STAT5B(1), STAT6(4), TPO(3), TYK2(3)	89448315	172	135	167	46	9	32	28	81	22	0	0.247	1.000	1.000
480	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY7(1), ADCY8(6), ADCY9(3), ADSL(1), ADSSL1(1), AK2(1), AK5(1), AK7(1), ALLC(2), AMPD1(1), AMPD2(1), AMPD3(3), ATIC(1), CANT1(1), ENPP3(1), ENTPD2(1), GART(1), GDA(1), GMPR(1), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(1), GUCY2F(2), HPRT1(1), IMPDH1(1), IMPDH2(1), NPR1(3), NPR2(2), NT5C1B(1), NT5C2(1), NT5C3(1), NT5M(2), NUDT9(1), PAPSS1(3), PAPSS2(2), PDE10A(1), PDE11A(3), PDE1A(1), PDE1C(1), PDE2A(1), PDE3B(1), PDE4A(2), PDE4B(2), PDE4C(6), PDE4D(1), PDE5A(1), PDE8A(2), PDE8B(1), PFAS(1), PKM2(1), POLA1(1), POLD1(3), POLD3(1), POLE(4), POLE2(1), POLR1A(3), POLR1B(2), POLR1C(3), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLR3A(4), POLR3B(5), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(5), PRPS1(1), PRPS1L1(1), PRPS2(2), PRUNE(2), RFC5(1), RRM1(2), RRM2(1), XDH(2)	101616272	152	127	148	36	10	23	15	66	35	3	0.226	1.000	1.000
481	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY7(1), ADCY8(6), ADCY9(3), ATF4(2), CACNA1C(8), CACNA1D(4), CACNA1F(3), CACNA1S(7), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CDC42(1), EGFR(7), ELK1(1), GNAS(4), GRB2(1), HRAS(1), ITPR1(2), ITPR2(8), ITPR3(3), JUN(2), KRAS(1), MAP2K3(9), MAP2K6(1), MAP2K7(1), MAP3K1(5), MAP3K2(2), MAP3K4(5), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), MMP14(1), MMP2(4), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLD1(2), PLD2(2), PRKACA(1), PRKACB(4), PRKACG(2), PRKCD(2), PTK2B(2), SOS1(6), SOS2(1), SRC(2)	80046947	153	121	148	46	21	20	14	78	20	0	0.513	1.000	1.000
482	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(4), ANAPC1(4), ANAPC11(1), ANAPC2(1), ANAPC4(1), ANAPC5(1), ANAPC7(2), ATM(15), ATR(5), BUB3(1), CCNA1(4), CCNB2(5), CCNB3(6), CCND2(1), CCNE1(2), CCNH(1), CDC14A(3), CDC16(2), CDC20(1), CDC23(2), CDC25A(1), CDC25C(2), CDC27(3), CDC7(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(5), CDKN2C(1), CHEK2(3), CREBBP(4), CUL1(3), E2F1(1), EP300(6), ESPL1(7), FZR1(4), HDAC1(2), MAD2L1(1), MCM2(3), MCM5(1), MCM6(2), MCM7(4), ORC1L(1), ORC2L(1), PCNA(3), PRKDC(7), RB1(1), RBL2(2), SKP2(1), SMAD2(2), SMAD3(1), SMAD4(1), SMC1A(2), SMC1B(2), TGFB2(2), TGFB3(1), TP53(10), WEE1(1), YWHAE(1)	85002005	159	118	157	38	10	22	24	67	36	0	0.171	1.000	1.000
483	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(2), AKT3(2), BCAR1(3), CAPN1(2), CAPN11(3), CAPN3(3), CAPN5(1), CAPN6(1), CAPN7(1), CAPN9(2), CDC42(1), CSK(2), DOCK1(1), FYN(1), GIT2(1), GRB2(1), ILK(1), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(1), ITGA9(1), ITGAD(2), ITGAE(3), ITGAL(4), ITGAM(3), ITGAX(2), ITGB1(3), ITGB2(1), ITGB3(1), ITGB4(1), ITGB5(3), ITGB6(2), ITGB7(2), ITGB8(1), MAP2K3(9), MAP2K6(1), MAPK10(1), MAPK12(1), MAPK4(1), MYLK2(1), PAK1(1), PAK4(2), PAK6(4), PIK3R2(2), PTK2(1), RAC1(1), RAC3(1), RAPGEF1(2), RHO(1), ROCK1(4), ROCK2(3), SDCCAG8(1), SEPP1(1), SHC1(2), SHC3(1), SORBS1(1), SOS1(6), SRC(2), TLN1(4), TNS1(5), VAV2(4), VCL(2), ZYX(1)	83668064	138	116	132	48	12	22	19	63	22	0	0.807	1.000	1.000
484	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(1), ARHGAP5(9), BCAR1(3), CD99(1), CDC42(1), CDH5(1), CLDN10(2), CLDN16(1), CLDN18(1), CLDN2(2), CLDN4(1), CLDN7(1), CLDN9(1), CTNNA1(2), CTNNA2(4), CTNNA3(2), CTNNB1(1), CTNND1(4), CXCR4(1), ESAM(1), F11R(1), GNAI1(1), GNAI2(1), GNAI3(1), GRLF1(6), ITGA4(1), ITGAL(4), ITGAM(3), ITGB1(3), ITGB2(1), ITK(1), MAPK12(1), MAPK13(1), MAPK14(1), MLLT4(5), MMP2(4), MMP9(1), MSN(2), MYL2(1), MYL7(1), MYL9(1), NCF1(1), NCF2(1), NOX1(2), NOX3(2), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG2(1), PRKCG(1), PTK2(1), PTK2B(2), PTPN11(1), RAC1(1), RAP1A(1), RAPGEF3(2), RAPGEF4(1), ROCK1(4), ROCK2(3), VAV1(2), VAV2(4), VCAM1(1), VCL(2)	76843470	142	115	136	48	10	26	17	58	30	1	0.672	1.000	1.000
485	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	161	ADORA2A(1), ADORA2B(1), ADRA1A(1), ADRB2(2), AGTR1(1), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCBP2(1), CCKAR(2), CCKBR(2), CCR5(3), CCR6(1), CCR9(1), CHML(1), CHRM2(2), CHRM3(2), CHRM5(2), CMKLR1(1), CNR1(1), CNR2(1), CXCR4(1), DRD1(1), DRD2(1), DRD3(2), DRD5(1), EDNRB(1), F2RL1(1), F2RL2(1), FPR1(1), GALR1(1), GALT(2), GPR17(1), GPR173(2), GPR174(2), GPR35(1), GPR37(1), GPR37L1(1), GPR4(1), GPR50(3), GPR63(1), GPR77(1), GPR83(1), GPR85(2), HCRTR2(1), HRH2(1), HTR1A(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(1), MAS1(1), MC3R(2), MC4R(1), MC5R(1), MTNR1B(1), NMBR(1), NMUR2(4), NPY1R(1), NTSR1(1), OPN1SW(1), OPRD1(3), OPRM1(2), OR12D3(1), OR1C1(1), OR1F1(1), OR5V1(2), OR7A5(1), OR7C1(3), OR8B8(2), P2RY10(1), P2RY11(1), P2RY12(1), P2RY13(1), P2RY14(1), P2RY2(1), P2RY6(1), PPYR1(2), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(2), PTGIR(1), RGR(1), RHO(1), SSTR1(2), SSTR3(1), SSTR4(1), TBXA2R(1), TRHR(2)	71443225	131	114	127	37	24	13	15	59	20	0	0.259	1.000	1.000
486	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(1), ACTG1(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(1), ACVR1B(4), ACVR1C(1), CDC42(1), CDH1(2), CREBBP(4), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(4), CTNNA3(2), CTNNB1(1), CTNND1(4), EGFR(7), EP300(6), ERBB2(4), FARP2(2), FGFR1(4), FYN(1), INSR(3), IQGAP1(5), LEF1(1), LMO7(4), MAP3K7(1), MAPK3(1), MET(3), MLLT4(5), PARD3(2), PTPN1(1), PTPN6(3), PTPRB(3), PTPRF(3), PTPRJ(4), PTPRM(3), PVRL2(2), PVRL3(2), RAC1(1), RAC3(1), SMAD2(2), SMAD3(1), SMAD4(1), SNAI1(1), SNAI2(2), SORBS1(1), SRC(2), SSX2IP(3), TCF7(2), TCF7L2(1), TGFBR2(1), TJP1(2), VCL(2), WASF2(1), WASF3(1), WASL(6), YES1(1)	74430827	138	114	136	39	11	15	24	67	21	0	0.480	1.000	1.000
487	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY7(1), ADCY8(6), ADCY9(3), DRD1(1), DRD2(1), EGF(4), EGFR(7), GJA1(2), GJD2(1), GNAI1(1), GNAI2(1), GNAI3(1), GNAS(4), GRB2(1), GRM1(4), GRM5(4), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(1), GUCY2F(2), HRAS(1), HTR2A(1), HTR2C(1), ITPR1(2), ITPR2(8), ITPR3(3), KRAS(1), MAP2K5(2), MAP3K2(2), MAPK3(1), NPR1(3), NPR2(2), PDGFC(1), PDGFD(1), PDGFRA(7), PDGFRB(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), PRKG1(2), PRKG2(2), SOS1(6), SOS2(1), SRC(2), TJP1(2), TUBA1A(1), TUBA3D(1), TUBA4A(2), TUBAL3(2), TUBB(2), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1)	81467808	144	114	141	45	16	19	15	68	26	0	0.675	1.000	1.000
488	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(4), ACTN1(1), ACTR2(1), AKT1(2), AKT2(3), AKT3(2), ARHGEF6(1), ARHGEF7(3), BCAR1(3), BRAF(1), CDC42(1), CDKN2A(5), CSE1L(2), DOCK1(1), EPHB2(1), FYN(1), GRB2(1), GRB7(2), GRLF1(6), ILK(1), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(1), ITGA9(1), MAP2K7(1), MAP3K11(1), MAPK10(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MRAS(1), MYLK(4), MYLK2(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PIK3CA(12), PIK3CB(1), PLCG2(1), PTEN(20), PTK2(1), RHO(1), ROCK1(4), ROCK2(3), SHC1(2), SOS1(6), SOS2(1), SRC(2), TLN1(4), TLN2(6), ZYX(1)	75577526	149	114	146	38	10	31	15	59	33	1	0.194	1.000	1.000
489	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM2(1), CDS2(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), FN3K(1), IMPA2(2), INPP4A(2), INPP4B(2), INPP5A(1), INPP5B(2), INPP5D(1), INPP5E(2), INPPL1(2), ITPKA(1), ITPKB(2), ITPR1(2), ITPR2(8), ITPR3(3), OCRL(1), PI4KA(8), PI4KB(1), PIK3C2B(3), PIK3C2G(2), PIK3C3(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP4K2A(1), PIP5K1A(2), PIP5K1C(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLCD3(1), PLCD4(3), PLCE1(3), PLCG2(1), PRKCG(1), PTEN(20), PTPMT1(1), SYNJ1(4), SYNJ2(5)	77975305	132	109	126	36	9	23	11	51	37	1	0.374	1.000	1.000
490	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTN2(3), ACTN3(1), ACTN4(1), DMD(5), FAM48A(1), MYBPC1(1), MYBPC2(3), MYBPC3(1), MYH3(5), MYH6(3), MYH7(2), MYH8(1), MYL1(1), MYL2(1), MYL9(1), MYOM1(3), NEB(11), TMOD1(2), TNNI1(1), TNNT1(2), TNNT3(1), TPM2(1), TTN(76)	87431342	127	108	127	35	12	22	10	57	24	2	0.427	1.000	1.000
491	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	BID(1), BRAF(1), FAS(1), FASLG(1), FCGR3B(1), FYN(1), GRB2(1), HLA-A(4), HLA-B(5), HLA-C(2), HLA-E(2), HRAS(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), IFNAR1(1), IFNB1(2), IFNGR1(2), IFNGR2(1), ITGAL(4), ITGB2(1), KIR3DL1(1), KLRC1(2), KLRC2(4), KRAS(1), LCP2(1), MAPK3(1), MICA(2), MICB(1), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), PAK1(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRF1(1), PRKCG(1), PTK2B(2), PTPN11(1), PTPN6(3), RAC1(1), RAC3(1), SH3BP2(1), SHC1(2), SHC2(1), SHC3(1), SOS1(6), SOS2(1), SYK(1), TNFSF10(1), ULBP2(1), ULBP3(1), VAV1(2), VAV2(4)	68850097	129	107	123	51	5	27	20	60	17	0	0.950	1.000	1.000
492	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY7(1), ADCY8(6), ADSL(1), AK2(1), AK5(1), ALLC(2), AMPD1(1), AMPD2(1), AMPD3(3), ATIC(1), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), CANT1(1), ENPP3(1), ENTPD2(1), GART(1), GDA(1), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(1), GUCY2F(2), HPRT1(1), IMPDH1(1), IMPDH2(1), NPR1(3), NPR2(2), NT5M(2), PAPSS1(3), PAPSS2(2), PDE1A(1), PDE4A(2), PDE4B(2), PDE4C(6), PDE4D(1), PDE5A(1), PDE6B(2), PDE6C(2), PDE8A(2), PFAS(1), PKM2(1), POLB(1), POLD1(3), POLE(4), POLG(2), POLL(2), POLQ(5), POLR1B(2), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLRMT(1), PRPS1(1), PRPS1L1(1), PRPS2(2), PRUNE(2), RRM1(2), RRM2(1)	79097280	124	107	124	27	13	14	12	57	28	0	0.158	1.000	1.000
493	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY7(1), ADCY8(6), ADCY9(3), AKAP1(3), AKAP11(1), AKAP12(3), AKAP2(4), AKAP3(1), AKAP4(2), AKAP6(4), AKAP7(1), AKAP9(12), ARHGEF1(1), CALM2(1), CHMP1B(3), GNA13(4), GNA15(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAZ(1), GNB1(2), GNB5(1), GNG12(1), GNG3(1), HRAS(1), IL18BP(1), ITPR1(2), KCNJ3(3), KRAS(1), PDE1A(1), PDE1B(2), PDE1C(1), PDE4A(2), PDE4B(2), PDE4C(6), PDE4D(1), PDE8A(2), PDE8B(1), PLCB3(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PRKCD(2), PRKCE(4), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(3), PRKCZ(2), PRKD1(3), PRKD3(2), SLC9A1(2), USP5(1)	72519872	133	105	130	32	12	18	5	65	33	0	0.345	1.000	1.000
494	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(2), AKT2(3), AKT3(2), BCL10(1), CARD11(4), CBL(1), CBLB(2), CBLC(1), CD28(1), CD3E(2), CD3G(1), CD4(2), CDC42(1), CDK4(1), CHUK(1), FYN(1), GRAP2(1), GRB2(1), HRAS(1), IL4(1), ITK(1), JUN(2), KRAS(1), LCP2(1), MALT1(2), MAP3K14(1), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NFKB1(1), NFKBIB(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PDK1(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCQ(3), PTPN6(3), PTPRC(6), SOS1(6), SOS2(1), TEC(5), VAV1(2), VAV2(4)	61999380	121	101	116	27	4	24	15	64	14	0	0.160	1.000	1.000
495	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(4), AMY2A(1), AMY2B(1), ASCC3(5), ATP13A2(4), DDX18(4), DDX23(2), DDX4(3), DDX47(1), DDX50(5), DDX54(1), DDX55(1), DHX58(1), ENPP3(1), EP400(5), ERCC2(1), ERCC3(1), G6PC(2), GAA(1), GANC(1), GBA(2), GBA3(2), GBE1(1), GUSB(6), GYS1(1), GYS2(1), HK1(4), IFIH1(2), MGAM(4), MOV10L1(3), PYGB(2), PYGL(1), PYGM(2), RAD54L(2), RUVBL2(2), SETX(5), SI(6), SMARCA2(4), SMARCA5(1), TREH(2), UGP2(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B10(1), UGT2B11(2), UGT2B15(1), UGT2B28(1), UGT2B4(2), UGT2B7(2), UXS1(1)	77200858	122	100	118	41	5	20	21	46	30	0	0.755	1.000	1.000
496	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	BRAF(1), CACNA1A(5), GNA13(4), GNAI1(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(4), GNAZ(1), GRIA1(4), GRIA2(3), GRID2(4), GRM1(4), GRM5(4), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(1), GUCY2F(2), HRAS(1), ITPR1(2), ITPR2(8), ITPR3(3), KRAS(1), MAPK3(1), NOS1(8), NOS3(2), NPR1(3), NPR2(2), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), PRKCG(1), PRKG1(2), PRKG2(2), RYR1(11)	68427272	115	100	115	44	17	13	11	55	19	0	0.906	1.000	1.000
497	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(4), ATM(15), BUB3(1), CCNA1(4), CCNB2(5), CCNB3(6), CCND2(1), CCNE1(2), CCNH(1), CDAN1(5), CDC14A(3), CDC20(1), CDC25A(1), CDC25C(2), CDC7(1), CDH1(2), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(5), CHEK2(3), E2F1(1), E2F5(1), EP300(6), ESPL1(7), HDAC1(2), HDAC4(1), HDAC6(4), MAD2L1(1), MCM2(3), MCM5(1), MCM6(2), MCM7(4), ORC1L(1), ORC2L(1), PCNA(3), PRKDC(7), PTPRA(1), RB1(1), SKP2(1), SMAD4(1), TBC1D8(1), TP53(10), WEE1(1)	68936071	127	99	123	35	9	21	24	49	24	0	0.260	1.000	1.000
498	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(4), ABL2(2), AKT1(2), AKT2(3), AKT3(2), BRAF(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CBL(1), CBLB(2), CBLC(1), CDKN1A(1), EGF(4), EGFR(7), ELK1(1), ERBB2(4), ERBB3(3), ERBB4(6), GAB1(1), GRB2(1), HRAS(1), JUN(2), KRAS(1), MAP2K7(1), MAPK10(1), MAPK3(1), MAPK9(2), MYC(1), NRG1(4), NRG2(2), NRG3(2), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG2(1), PRKCG(1), PTK2(1), RPS6KB1(1), RPS6KB2(1), SHC1(2), SHC2(1), SHC3(1), SOS1(6), SOS2(1), SRC(2), STAT5B(1)	63099338	119	99	114	29	9	28	14	57	11	0	0.116	1.000	1.000
499	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1B(4), AKT1(2), AURKB(1), BMPR2(4), CDS2(1), CLK1(4), CLK2(2), CLK4(2), COL4A3BP(1), CSNK2A2(1), CSNK2B(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), INPP4A(2), INPP4B(2), INPP5A(1), INPPL1(2), ITPKA(1), ITPKB(2), MAP3K10(3), NEK1(2), NEK3(2), OCRL(1), PAK4(2), PIK3C2B(3), PIK3C2G(2), PIK3CA(12), PIK3CB(1), PIK3CG(3), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLCG2(1), PLK3(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PRKCD(2), PRKCE(4), PRKCG(1), PRKCH(2), PRKCQ(3), PRKCZ(2), PRKD1(3), PRKG1(2), RPS6KA1(2), RPS6KB1(1), STK11(1)	70509482	115	98	110	30	8	24	7	51	25	0	0.313	1.000	1.000
500	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(7), ABCA10(4), ABCA12(7), ABCA13(12), ABCA2(3), ABCA3(3), ABCA4(5), ABCA5(6), ABCA6(1), ABCA7(6), ABCA8(3), ABCA9(2), ABCB1(4), ABCB11(1), ABCB4(1), ABCB5(3), ABCB6(1), ABCC1(2), ABCC10(3), ABCC11(1), ABCC12(3), ABCC2(1), ABCC3(7), ABCC4(3), ABCC5(6), ABCC6(4), ABCC8(1), ABCC9(4), ABCD2(1), ABCD3(2), ABCD4(3), ABCG1(1), ABCG4(3), ABCG5(1), ABCG8(2), CFTR(4)	72984357	121	94	119	39	6	20	17	60	17	1	0.655	1.000	1.000
501	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY7(1), ADCY8(6), ADCY9(3), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CREB3L1(1), CREB3L2(1), CREB3L3(1), CREB3L4(1), CREBBP(4), CTNNB1(1), DCT(4), DVL1(1), EDNRB(1), EP300(6), FZD1(2), FZD10(2), FZD3(1), FZD4(3), FZD5(1), GNAI1(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(4), HRAS(1), KIT(3), KITLG(2), KRAS(1), LEF1(1), MAPK3(1), MITF(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), TCF7(2), TCF7L2(1), TYR(3), TYRP1(1), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(1)	65676689	108	93	107	30	9	10	13	58	18	0	0.495	1.000	1.000
502	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(1), ALG10(2), ALG10B(2), ALG12(1), ALG13(3), ALG14(1), ALG3(1), ALG6(1), ALG8(2), B3GNT2(2), B3GNT6(1), B3GNT7(1), B4GALT3(1), B4GALT4(2), B4GALT5(1), CHST1(1), CHST11(1), CHST12(1), CHST4(1), CHST7(1), CHSY1(3), DPAGT1(2), EXT1(1), EXT2(1), EXTL1(1), EXTL3(2), FUT11(1), GALNT1(1), GALNT10(1), GALNT11(3), GALNT13(3), GALNT14(1), GALNT2(1), GALNT5(5), GALNT6(1), GALNT7(5), GALNT9(1), GALNTL2(1), GALNTL4(1), GALNTL5(2), GCNT1(2), GCNT4(1), HS2ST1(1), HS3ST5(1), MAN1A1(2), MAN1A2(1), MAN2A1(2), MGAT4A(2), MGAT4B(1), MGAT5(2), MGAT5B(1), NDST1(2), NDST2(2), NDST4(3), OGT(4), RPN1(2), RPN2(1), ST3GAL1(1), ST3GAL3(1), ST6GALNAC1(1), STT3B(2), WBSCR17(4), XYLT1(1), XYLT2(2)	66116349	106	92	106	35	4	20	14	46	22	0	0.773	1.000	1.000
503	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1B(4), ACVR1C(1), ACVR2A(1), ACVR2B(1), AMHR2(2), BMP2(1), BMP5(1), BMP6(1), BMP7(2), BMP8B(1), BMPR1B(1), BMPR2(4), CHRD(2), CREBBP(4), CUL1(3), DCN(3), E2F5(1), EP300(6), GDF5(1), GDF6(1), INHBA(2), INHBB(1), INHBC(1), INHBE(1), LTBP1(2), MAPK3(1), MYC(1), PITX2(1), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), RBL2(2), ROCK1(4), ROCK2(3), RPS6KB1(1), RPS6KB2(1), SMAD2(2), SMAD3(1), SMAD4(1), SMAD9(1), SMURF2(3), TGFB2(2), TGFB3(1), TGFBR2(1), THBS1(6), THBS2(1), THBS3(6), THBS4(3), ZFYVE16(1), ZFYVE9(4)	60246080	106	92	105	28	5	10	15	54	22	0	0.505	1.000	1.000
504	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(1), ADCY8(6), ATF4(2), BRAF(1), CACNA1C(8), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CREBBP(4), EP300(6), GRIA1(4), GRIA2(3), GRIN1(2), GRIN2A(4), GRIN2B(5), GRM1(4), GRM5(4), HRAS(1), ITPR1(2), ITPR2(8), ITPR3(3), KRAS(1), MAPK3(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PPP1R12A(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), RAP1A(1), RAPGEF3(2), RPS6KA1(2), RPS6KA6(1)	62722718	103	90	103	24	13	14	10	53	13	0	0.137	1.000	1.000
505	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	91	CABIN1(6), CALM2(1), CAMK2B(1), CAMK4(1), CD3E(2), CD3G(1), CDKN1A(1), CNR1(1), CREBBP(4), CSNK2B(1), EGR2(1), EGR3(1), EP300(6), GATA4(1), GRLF1(6), GSK3A(2), HRAS(1), IFNA1(2), IFNB1(2), IL2RA(2), IL3(1), IL4(1), ITK(1), JUNB(2), MAP2K7(1), MAPK14(1), MAPK9(2), MEF2A(2), MEF2D(1), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NFKBIB(1), NPPB(1), NUP214(2), OPRD1(3), PAK1(1), PPP3CC(1), PTPRC(6), RELA(1), SP3(1), TRPV6(4), VAV1(2), VAV2(4), XPO5(2)	55354822	100	88	99	26	8	15	14	48	15	0	0.312	1.000	1.000
506	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	84	ANPEP(6), CD19(1), CD1D(3), CD1E(1), CD22(1), CD24(1), CD33(1), CD34(1), CD38(1), CD3E(2), CD3G(1), CD4(2), CD44(1), CD55(1), CD7(3), CR1(7), CR2(1), CSF1R(5), CSF2RA(3), CSF3R(2), DNTT(2), FLT3(2), GYPA(1), HLA-DRA(1), HLA-DRB1(12), HLA-DRB5(8), IL1R1(1), IL2RA(2), IL3(1), IL4(1), IL4R(2), IL9R(3), ITGA1(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGAM(3), ITGB3(1), KIT(3), KITLG(2), MME(3), TPO(3)	50449603	107	88	104	27	8	9	20	50	19	1	0.353	1.000	1.000
507	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CDC40(1), CLK2(2), CLK4(2), COL2A1(5), CPSF1(3), CPSF2(2), CPSF3(2), CPSF4(2), CSTF2T(1), CSTF3(3), DDX1(1), DDX20(4), DHX15(3), DHX8(1), DHX9(4), DICER1(2), FUS(4), LSM7(1), METTL3(4), NONO(2), NUDT21(2), NXF1(1), PABPN1(1), PAPOLA(3), POLR2A(6), PRPF3(1), PRPF4B(1), PRPF8(7), PSKH1(2), PTBP2(1), RBM17(1), RNMT(1), SF3A1(1), SF3A3(2), SF3B1(4), SF3B2(2), SF4(1), SFRS12(1), SFRS16(1), SFRS2(1), SNRPB(1), SNRPN(2), SRPK2(2), SRRM1(1), SUPT5H(5), TXNL4A(1), U2AF2(1), XRN2(3)	65315822	105	87	104	29	4	25	10	45	20	1	0.414	1.000	1.000
508	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(2), AKT2(3), AKT3(2), BTK(1), FYN(1), GAB2(1), GRB2(1), HRAS(1), IL3(1), IL4(1), INPP5D(1), KRAS(1), LCP2(1), MAP2K3(9), MAP2K6(1), MAP2K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), MS4A2(1), PDK1(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCG2(1), PRKCD(2), PRKCE(4), RAC1(1), RAC3(1), SOS1(6), SOS2(1), SYK(1), VAV1(2), VAV2(4)	44675958	87	77	78	29	10	18	11	40	8	0	0.581	1.000	1.000
509	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(15), CCNA1(4), CCND2(1), CCNE1(2), CCNG2(1), CCNH(1), CDC25A(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(5), CDKN2C(1), CREB3L1(1), CREB3L3(1), CREB3L4(1), E2F1(1), E2F5(1), GBA2(4), MCM2(3), MCM5(1), MCM6(2), MCM7(4), MYC(1), MYT1(2), NACA(1), ORC1L(1), ORC2L(1), PCNA(3), POLE(4), POLE2(1), PRIM1(2), RB1(1), RPA2(1), RPA3(1), TFDP2(5), TNXB(2), TP53(10), WEE1(1)	46187944	91	73	91	25	6	11	12	40	22	0	0.506	1.000	1.000
510	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	69	ACACB(3), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(4), AKT1(2), AKT2(3), AKT3(2), CAMKK1(1), CAMKK2(2), CHUK(1), CPT1A(1), G6PC(2), IRS1(3), IRS4(1), JAK1(4), JAK2(5), JAK3(4), LEP(1), LEPR(1), MAPK10(1), MAPK9(2), NFKB1(1), NFKBIB(1), NPY(1), PCK1(4), PCK2(1), PPARGC1A(3), PRKAG1(1), PRKAG2(4), PRKCQ(3), PTPN11(1), RELA(1), RXRB(3), RXRG(2), SLC2A4(1), STAT3(1), STK11(1), TNFRSF1A(1), TRADD(1), TYK2(3)	49830098	80	73	80	22	3	15	12	34	16	0	0.443	1.000	1.000
511	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(2), AKT2(3), AKT3(2), CDC42(1), HRAS(1), KDR(5), KRAS(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPKAPK2(2), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NOS3(2), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCG(1), PTGS2(4), PTK2(1), RAC1(1), RAC3(1), SHC2(1), SPHK2(1), SRC(2)	44021378	82	72	76	30	4	17	10	40	11	0	0.778	1.000	1.000
512	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(2), CALR(1), CANX(1), CD4(2), CD74(1), CIITA(2), CTSB(3), CTSL1(2), CTSS(1), HLA-A(4), HLA-B(5), HLA-C(2), HLA-DPA1(1), HLA-DPB1(2), HLA-DQB1(4), HLA-DRA(1), HLA-DRB1(12), HLA-DRB5(8), HLA-E(2), HLA-F(1), HSP90AA1(4), HSP90AB1(3), HSPA5(2), IFI30(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), KIR2DS4(1), KIR3DL1(1), KIR3DL3(1), KLRC1(2), KLRC2(4), LTA(1), RFX5(1)	25594534	86	71	80	34	7	12	12	38	17	0	0.945	1.000	1.000
513	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	49	ACOX1(1), CREBBP(4), EHHADH(3), EP300(6), FABP1(1), HSD17B4(1), JUN(2), LPL(1), MAPK3(1), ME1(1), MYC(1), NCOA1(2), NCOR1(5), NCOR2(4), NR1H3(1), NRIP1(6), PIK3CA(12), PIK3R1(2), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PTGS2(4), RB1(1), RELA(1), SRA1(3), STAT5B(1)	38546269	73	68	69	19	4	17	11	37	4	0	0.191	1.000	1.000
514	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACADM(1), ACOX1(1), ACOX2(1), ACOX3(2), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(4), ANGPTL4(2), APOA5(2), AQP7(5), CPT1A(1), CYP4A11(4), CYP4A22(1), CYP8B1(3), DBI(1), EHHADH(3), FABP1(1), FADS2(2), GK2(1), HMGCS2(1), ILK(1), LPL(1), ME1(1), MMP1(1), NR1H3(1), PCK1(4), PCK2(1), PLTP(2), PPARD(1), PPARG(1), RXRB(3), RXRG(2), SCP2(2), SLC27A1(2), SLC27A2(1), SLC27A5(2), SLC27A6(5), SORBS1(1), UBC(2), UCP1(1)	39806181	74	66	72	26	5	10	15	31	13	0	0.761	1.000	1.000
515	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(1), BMP5(1), BMP6(1), BMP7(2), BMP8B(1), BTRC(2), CSNK1A1(1), CSNK1G1(1), CSNK1G2(1), CSNK1G3(1), FBXW11(1), GLI1(3), GLI2(4), GLI3(3), HHIP(2), LRP2(13), PRKACA(1), PRKACB(4), PRKACG(2), PTCH1(7), PTCH2(1), SHH(1), SMO(3), STK36(2), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(1)	35583288	68	61	66	21	6	8	8	39	7	0	0.711	1.000	1.000
516	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AASDHPPT(2), AASS(4), AKR1B10(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), BBOX1(2), DLST(1), DOT1L(2), ECHS1(2), EHHADH(3), EHMT1(1), EHMT2(3), HADH(1), HADHA(1), HSD17B4(1), NSD1(4), OGDH(3), OGDHL(2), PIPOX(1), PLOD1(1), PLOD2(4), PLOD3(2), RDH11(3), SETD1A(2), SETDB1(4), SHMT1(2), SHMT2(3), SPCS1(1), SUV39H2(3), TMLHE(1)	34935687	67	59	67	19	6	14	9	23	15	0	0.382	1.000	1.000
517	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(4), CTBP1(1), CTBP2(1), DLL1(1), DLL4(2), DTX1(2), DVL1(1), EP300(6), HDAC1(2), JAG1(1), JAG2(2), MAML1(4), MAML2(2), MAML3(5), NCOR2(4), NCSTN(1), NOTCH1(5), NOTCH2(9), NOTCH3(6), NOTCH4(1), NUMB(2), NUMBL(1), PSEN2(3), PSENEN(1), RBPJ(2), RBPJL(1), SNW1(1)	40444145	71	59	71	31	7	7	14	30	13	0	0.943	1.000	1.000
518	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), ASCC3(5), ATP13A2(4), DDX18(4), DDX23(2), DDX4(3), DDX47(1), DDX50(5), DDX54(1), DDX55(1), DHX58(1), EP400(5), ERCC2(1), ERCC3(1), FPGS(2), IFIH1(2), MOV10L1(3), QDPR(1), RAD54L(2), RUVBL2(2), SETX(5), SMARCA2(4), SMARCA5(1)	38574277	66	58	66	19	1	18	10	21	16	0	0.357	1.000	1.000
519	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(4), ATP4A(3), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), COX15(1), COX17(1), COX6A2(1), COX6B2(1), COX7A2(1), NDUFA10(2), NDUFA13(2), NDUFA3(1), NDUFA4L2(2), NDUFA6(1), NDUFA7(1), NDUFB6(1), NDUFC1(2), NDUFS1(4), NDUFS2(1), NDUFS3(1), NDUFS5(1), NDUFS8(1), NDUFV2(1), PPA2(2), SDHA(1), SDHB(1), SDHD(1), UQCRC2(1), UQCRFS1(3)	34655460	60	56	57	23	5	6	11	26	12	0	0.922	1.000	1.000
520	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(1), DAXX(4), EGF(4), EGFR(7), HRAS(1), JUN(2), MAP2K3(9), MAP2K6(1), MAP2K7(1), MAP3K1(5), MAP3K14(1), MAP3K5(5), MAPK13(1), MAPK14(1), MAPK3(1), NFKB1(1), PPP2CA(1), PRKCD(2), PRKCE(4), PRKCG(1), PRKCH(2), PRKCQ(3), RELA(1), RIPK1(1), TNFRSF1A(1)	30112622	61	56	55	20	8	5	3	29	16	0	0.827	1.000	1.000
521	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(6), AXIN1(2), CCND2(1), CTNNB1(1), DVL1(1), FZD1(2), FZD10(2), FZD3(1), FZD5(1), JUN(2), LDLR(1), MAPK10(1), MAPK9(2), MYC(1), PAFAH1B1(1), PLAU(4), PRKCD(2), PRKCE(4), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(3), PRKCZ(2), PRKD1(3), RAC1(1), SFRP4(4), TCF7(2), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT5B(1), WNT7B(1)	35605677	61	56	58	22	5	11	6	28	11	0	0.791	1.000	1.000
522	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM2(1), CD3E(2), CD3G(1), ELK1(1), FYN(1), GRB2(1), HRAS(1), JUN(2), MAP3K1(5), MAPK3(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NFKB1(1), PIK3CA(12), PIK3R1(2), PPP3CA(1), PPP3CC(1), PTPN7(1), RAC1(1), RASA1(3), RELA(1), SHC1(2), SOS1(6), SYT1(1), VAV1(2)	28912835	59	55	56	17	5	16	7	24	7	0	0.405	1.000	1.000
523	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	ABO(4), B3GALT2(2), B3GALT4(1), B3GNT2(2), B3GNT3(1), B3GNT5(1), B4GALT3(1), B4GALT4(2), B4GALT6(1), FUT1(1), FUT6(3), GBGT1(2), GCNT2(4), PIGB(1), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(1), PIGN(1), PIGO(1), PIGP(1), PIGQ(5), PIGS(1), PIGT(2), PIGU(1), PIGV(1), PIGZ(1), ST3GAL1(1), ST3GAL3(1), ST3GAL5(1), ST3GAL6(1), ST6GALNAC3(2), ST6GALNAC5(2), ST8SIA1(2), ST8SIA5(1)	29538729	57	54	54	17	5	8	8	19	16	1	0.670	1.000	1.000
524	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(2), ARHGDIB(1), BAG4(1), BID(1), BIRC2(3), BIRC3(2), CASP2(1), CASP7(1), CFLAR(1), CHUK(1), DAXX(4), GSN(1), LMNB1(1), MAP2K7(1), MAP3K1(5), MAP3K14(1), MAP3K5(5), NFKB1(1), NUMA1(2), PRKCD(2), PRKDC(7), PSEN2(3), PTK2(1), RASA1(3), RB1(1), RELA(1), RIPK1(1), SPTAN1(5), TNFRSF1A(1), TRADD(1)	42948439	61	52	60	20	2	15	7	26	11	0	0.703	1.000	1.000
525	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(3), ACSS2(3), ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(1), ALDH3B2(2), ALDH7A1(1), ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(2), ENO2(1), FBP1(1), G6PC(2), GALM(2), GAPDHS(1), HK1(4), LDHAL6B(1), LDHB(1), LDHC(1), PDHA1(1), PDHA2(1), PDHB(1), PFKL(1), PFKM(2), PGAM1(1), PGAM2(1), PGK1(2), PKM2(1), TPI1(1)	35889358	59	52	58	19	4	5	7	25	18	0	0.817	1.000	1.000
526	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(4), ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), CDC42(1), CHUK(1), CSK(2), EGFR(7), F11R(1), GIT1(2), JUN(2), MAP3K14(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK9(2), MET(3), NFKB1(1), NOD1(2), PAK1(1), PLCG2(1), PTPN11(1), PTPRZ1(8), RAC1(1), RELA(1), SRC(2), TJP1(2)	43767104	62	52	61	20	3	11	9	30	9	0	0.775	1.000	1.000
527	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	ABP1(5), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOC2(3), AOC3(1), AOX1(7), CAT(2), CYP1A1(1), CYP1A2(3), DDC(2), ECHS1(2), EHHADH(3), HADH(1), HADHA(1), HSD17B4(1), LCMT1(1), LCMT2(3), MAOA(1), NFX1(1), OGDH(3), OGDHL(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), TPH1(1), TPH2(1), WARS2(1)	37332426	58	51	58	16	4	11	9	25	9	0	0.505	1.000	1.000
528	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(5), AGMAT(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH4A1(1), AOC2(3), AOC3(1), ARG1(1), ASL(1), CPS1(6), DAO(1), GATM(2), GOT1(3), GOT2(2), MAOA(1), NOS1(8), NOS3(2), ODC1(1), OTC(1), P4HA1(2), P4HA2(1), P4HA3(1), PYCR1(1), SMS(2)	27134161	55	49	55	20	2	4	13	25	11	0	0.841	1.000	1.000
529	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(1), CALM2(1), ELK1(1), GRB2(1), HRAS(1), JUN(2), MAP2K7(1), MAP3K1(5), MAPK3(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), PIK3CA(12), PIK3R1(2), PLA2G4A(1), PPP3CA(1), PPP3CC(1), SHC1(2), SOS1(6), SYK(1), SYT1(1), VAV1(2)	25935673	52	49	49	16	5	12	6	22	7	0	0.497	1.000	1.000
530	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	BID(1), BIRC2(3), BIRC3(2), CASP1(1), CASP10(3), CASP2(1), CASP7(1), CHUK(1), FAS(1), FASLG(1), HELLS(2), JUN(2), LTA(1), MAP3K1(5), MAPK10(1), MYC(1), NFKB1(1), NFKBIB(1), PRF1(1), RELA(1), RIPK1(1), TNFRSF1A(1), TNFSF10(1), TP53(10), TP73(3), TRADD(1), TRAF3(1)	34651207	49	48	49	15	2	8	7	22	10	0	0.588	1.000	1.000
531	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(4), AMY2A(1), AMY2B(1), ENPP3(1), G6PC(2), GAA(1), GBA3(2), GBE1(1), GUSB(6), GYS1(1), GYS2(1), HK1(4), MGAM(4), PYGB(2), PYGL(1), PYGM(2), RNPC3(2), SI(6), UCHL3(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2), UXS1(1)	35652492	55	48	52	15	4	6	11	21	13	0	0.456	1.000	1.000
532	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTG1(2), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(1), FYN(1), HCLS1(1), ITGB1(3), LY96(1), NCL(3), ROCK1(4), ROCK2(3), TLR4(2), TLR5(2), TUBA1A(1), TUBA3D(1), TUBA4A(2), TUBAL3(2), TUBB(2), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1), WASL(6)	31677284	53	47	53	28	4	12	9	22	6	0	0.981	1.000	1.000
533	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(4), ACTG1(2), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(1), FYN(1), HCLS1(1), ITGB1(3), LY96(1), NCL(3), ROCK1(4), ROCK2(3), TLR4(2), TLR5(2), TUBA1A(1), TUBA3D(1), TUBA4A(2), TUBAL3(2), TUBB(2), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1), WASL(6)	31677284	53	47	53	28	4	12	9	22	6	0	0.981	1.000	1.000
534	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(1), AARS2(1), CARS(4), CARS2(2), DARS(1), EPRS(2), FARSA(1), HARS(1), HARS2(1), IARS(4), IARS2(2), KARS(1), LARS(3), LARS2(1), MARS(2), MARS2(3), NARS2(4), PARS2(2), SARS(3), TARS(2), TARS2(3), VARS(2), VARS2(1), WARS2(1), YARS(1)	32597040	49	46	48	13	1	9	6	25	8	0	0.457	1.000	1.000
535	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	70	ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), AKR1C1(1), ALDH3B1(1), ALDH3B2(2), CYP1A1(1), CYP1A2(3), CYP2B6(1), CYP2C19(1), CYP2E1(1), CYP3A7(1), DHDH(3), EPHX1(4), GSTA3(1), GSTA4(1), GSTM1(1), GSTM5(1), MGST3(2), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B10(1), UGT2B11(2), UGT2B15(1), UGT2B28(1), UGT2B4(2), UGT2B7(2)	35849687	54	46	52	19	5	6	8	22	13	0	0.829	1.000	1.000
536	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ABP1(5), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), AOC2(3), AOC3(1), AOX1(7), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(3), CYP2A13(2), CYP2B6(1), CYP2C19(1), CYP2D6(1), CYP2E1(1), CYP2J2(2), CYP3A7(1), CYP4B1(3), DDC(2), ECHS1(2), EHHADH(3), HADHA(1), MAOA(1), TPH1(1), WARS2(1)	33897692	54	46	54	20	4	10	7	26	7	0	0.807	1.000	1.000
537	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(1), ATP8A1(1), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(2), CCR5(3), CCR6(1), CXCR4(1), CXCR6(1), EDNRB(1), FPR1(1), GALR1(1), GALT(2), GPR77(1), MC2R(2), MC3R(2), MC4R(1), MC5R(1), NMBR(1), NPY1R(1), NTSR1(1), OPRD1(3), OPRM1(2), PPYR1(2), SSTR1(2), SSTR3(1), SSTR4(1), TACR1(2), TACR2(1), TACR3(2), TRHR(2)	31235819	52	45	50	16	13	5	5	24	5	0	0.358	1.000	1.000
538	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(1), CD28(1), CSK(2), EPHB2(1), FBXW7(1), GRAP2(1), GRB2(1), ITK(1), ITPKA(1), ITPKB(2), LCP2(1), NFAT5(7), NFKB1(1), NFKBIB(1), NFKBIL1(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PTPRC(6), RASGRP2(2), RASGRP3(1), RASGRP4(2), SOS1(6), SOS2(1), VAV1(2)	34244885	51	45	50	17	6	9	4	25	7	0	0.735	1.000	1.000
539	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTN1(1), ACTN2(3), ACTN3(1), BCAR1(3), BCR(1), CAPN1(2), CSK(2), FYN(1), GRB2(1), HRAS(1), ITGA1(3), ITGB1(3), JUN(2), MAPK3(1), PTK2(1), RAP1A(1), ROCK1(4), SHC1(2), SOS1(6), SRC(2), TLN1(4), VCL(2), ZYX(1)	28961613	48	44	48	15	5	8	2	24	9	0	0.737	1.000	1.000
540	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(6), CREBBP(4), EP300(6), ERCC3(1), GTF2A1(1), GTF2F1(1), HDAC1(2), HDAC4(1), HDAC6(4), NCOR2(4), NRIP1(6), PELP1(1), POLR2A(6), SRA1(3), TBP(1)	28772970	47	43	45	19	0	9	10	22	6	0	0.751	1.000	1.000
541	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC7(1), CDK2(2), CDT1(1), DIAPH2(2), MCM10(1), MCM2(3), MCM5(1), MCM6(2), MCM7(4), NACA(1), ORC1L(1), ORC2L(1), PCNA(3), POLD1(3), POLD3(1), POLE(4), POLE2(1), PRIM1(2), RFC1(4), RFC2(1), RFC4(1), RFC5(1), RPA2(1), RPA3(1), RPA4(1), RPS27A(1), UBC(2)	31494222	47	43	47	18	3	6	6	22	10	0	0.833	1.000	1.000
542	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(2), ENO2(1), FBP1(1), G6PC(2), GAPDHS(1), GOT1(3), GOT2(2), HK1(4), LDHAL6B(1), LDHB(1), LDHC(1), MDH1(1), PC(1), PCK1(4), PDHA1(1), PDHA2(1), PDHB(1), PDHX(1), PFKL(1), PFKM(2), PGAM1(1), PGAM2(1), PGK1(2), PKM2(1), TNFAIP1(1), TPI1(1)	26101135	48	43	48	16	2	4	6	17	19	0	0.808	1.000	1.000
543	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	ARSD(7), ARSE(1), CYP11B2(2), CYP19A1(2), HSD17B1(1), HSD17B8(1), HSD3B1(1), LCMT1(1), LCMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), SULT2A1(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B10(1), UGT2B11(2), UGT2B15(1), UGT2B28(1), UGT2B4(2), UGT2B7(2)	30876617	48	43	46	16	5	5	6	22	10	0	0.783	1.000	1.000
544	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(4), ACACB(3), ACSS1(3), ACSS2(3), AKR1B1(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), DLAT(2), DLD(2), GRHPR(2), HAGH(1), LDHAL6B(1), LDHB(1), LDHC(1), MDH1(1), ME1(1), ME2(2), ME3(2), PC(1), PCK1(4), PCK2(1), PDHA1(1), PDHA2(1), PDHB(1), PKM2(1)	28772098	47	43	47	15	0	7	10	15	15	0	0.726	1.000	1.000
545	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(1), AGPAT6(1), CDS2(1), CHKB(1), CHPT1(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), ESCO1(2), ESCO2(1), ETNK1(2), GPAM(1), LCAT(1), LYPLA1(1), MYST3(4), MYST4(4), PCYT1B(1), PISD(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLD1(2), PLD2(2), PNPLA3(2), PPAP2B(1), PPAP2C(2), PTDSS1(2), SH3GLB1(1)	40535957	47	42	47	11	6	5	9	22	5	0	0.239	1.000	1.000
546	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(1), ACACA(4), ACACB(3), ACADM(1), ACSS1(3), ACSS2(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), ECHS1(2), EHHADH(3), HADHA(1), LDHAL6B(1), LDHB(1), LDHC(1), MCEE(1), MLYCD(1), MUT(2), PCCA(1), PCCB(2), SUCLG1(5), SUCLG2(1)	24582680	43	42	43	15	2	5	12	14	10	0	0.773	1.000	1.000
547	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(4), ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), ATP7A(3), ATP7B(5), COX6A2(1), COX7A2(1), NDUFA10(2), NDUFB6(1), NDUFS1(4), NDUFS2(1), NDUFV2(1), PPA2(2), SDHA(1), SDHB(1), SHMT1(2), UQCRFS1(3)	23852880	43	42	40	16	2	7	9	17	8	0	0.836	1.000	1.000
548	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(1), ALDH3B2(2), ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(2), ENO2(1), FBP1(1), G6PC(2), HK1(4), LDHB(1), LDHC(1), PDHA1(1), PDHA2(1), PDHB(1), PFKM(2), PGAM1(1), PGK1(2), PKM2(1), TPI1(1)	30105215	47	41	46	18	4	2	5	22	14	0	0.933	1.000	1.000
549	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(1), ALDH3B2(2), ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(2), ENO2(1), FBP1(1), G6PC(2), HK1(4), LDHB(1), LDHC(1), PDHA1(1), PDHA2(1), PDHB(1), PFKM(2), PGAM1(1), PGK1(2), PKM2(1), TPI1(1)	30105215	47	41	46	18	4	2	5	22	14	0	0.933	1.000	1.000
550	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM2(1), CAMK1(1), ELK1(1), FPR1(1), GNA15(1), GNB1(2), HRAS(1), MAP2K3(9), MAP2K6(1), MAP3K1(5), MAPK14(1), MAPK3(1), NCF1(1), NCF2(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), NFKB1(1), PAK1(1), PIK3C2G(2), PLCB1(1), PPP3CA(1), PPP3CC(1), RAC1(1), RELA(1), SYT1(1)	23572453	46	40	42	15	8	5	3	21	9	0	0.692	1.000	1.000
551	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(1), ARG1(1), ASL(1), ASS1(2), CPS1(6), DAO(1), EPRS(2), GATM(2), GOT1(3), GOT2(2), LAP3(2), NOS1(8), NOS3(2), OTC(1), P4HA1(2), P4HA2(1), P4HA3(1), PARS2(2), PRODH(1), PYCR1(1), PYCR2(1)	22160264	43	40	43	16	2	3	11	19	8	0	0.807	1.000	1.000
552	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	ALOX15B(2), ALOX5(2), CBR1(2), CYP2B6(1), CYP2C19(1), CYP2E1(1), CYP2J2(2), CYP2U1(1), CYP4A11(4), CYP4A22(1), CYP4F2(1), DHRS4(1), EPHX2(1), GGT1(2), GPX3(2), GPX4(1), GPX5(1), GPX6(1), LTA4H(4), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PTGDS(1), PTGES(1), PTGS1(1), PTGS2(4), TBXAS1(1)	24062020	43	40	42	17	6	5	10	16	6	0	0.713	1.000	1.000
553	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), B4GALT5(1), GALNT1(1), GALNT10(1), GALNT11(3), GALNT13(3), GALNT14(1), GALNT2(1), GALNT5(5), GALNT6(1), GALNT7(5), GALNT9(1), GALNTL2(1), GALNTL4(1), GALNTL5(2), GCNT1(2), GCNT4(1), OGT(4), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(4)	20081807	41	39	41	15	1	6	8	20	6	0	0.845	1.000	1.000
554	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	GRB2(1), HRAS(1), JAK2(5), JUN(2), MAPK3(1), PIK3CA(12), PIK3R1(2), RASA1(3), SHC1(2), SOS1(6), STAT1(4), STAT3(1), STAT5B(1)	18406087	41	39	38	12	3	10	4	21	3	0	0.504	1.000	1.000
555	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	BID(1), BIRC2(3), BIRC3(2), CASP2(1), CASP7(1), FAS(1), FASLG(1), JUN(2), MAP3K1(5), MAP3K14(1), MAPK10(1), MYC(1), NFKB1(1), PARP1(2), PRF1(1), RELA(1), RIPK1(1), TNFRSF1A(1), TNFSF10(1), TP53(10), TRADD(1)	22678554	39	37	39	15	2	8	7	15	7	0	0.811	1.000	1.000
556	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(5), ADC(1), AGMAT(2), ALDH18A1(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOC2(3), AOC3(1), ARG1(1), ASL(1), ASS1(2), CPS1(6), GATM(2), MAOA(1), ODC1(1), OTC(1), SAT1(1), SAT2(1), SMS(2)	18081719	38	37	38	13	0	5	8	19	6	0	0.805	1.000	1.000
557	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	INPP4A(2), INPP4B(2), INPP5A(1), INPPL1(2), ITPKA(1), ITPKB(2), MIOX(2), OCRL(1), PIK3C2B(3), PIK3C2G(2), PIK3CA(12), PIK3CB(1), PIK3CG(3), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLCG2(1)	27910396	43	37	39	16	2	8	3	20	10	0	0.884	1.000	1.000
558	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(1), AKT1(2), ASAH1(1), GNAI1(1), GNB1(2), ITGB3(1), MAPK3(1), PDGFRA(7), PIK3CA(12), PIK3R1(2), PLCB1(1), PTK2(1), RAC1(1), SMPD1(1), SMPD2(2), SRC(2)	16944584	38	36	35	14	1	10	4	16	7	0	0.765	1.000	1.000
559	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2), AKR1B1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), GLB1(4), LCT(2), LIPC(1), LIPF(1), LPL(1), PNLIP(3), PNLIPRP2(1), PPAP2B(1), PPAP2C(2)	29842836	39	36	38	14	5	8	4	15	7	0	0.728	1.000	1.000
560	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(3), ACO1(4), CLYBL(2), CS(2), DLD(2), DLST(1), IDH1(2), IDH3B(1), IDH3G(1), MDH1(1), OGDH(3), OGDHL(2), PC(1), PCK1(4), PCK2(1), SDHA(1), SDHB(1), SDHD(1), SUCLG1(5), SUCLG2(1)	18584106	39	36	39	14	4	5	4	18	8	0	0.815	1.000	1.000
561	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), AKR1B10(2), ALDOA(2), ALDOB(3), FBP1(1), FPGT(1), FUK(1), GMPPB(1), HK1(4), KHK(4), MPI(1), MTMR1(1), MTMR2(1), PFKFB3(1), PFKL(1), PFKM(2), PGM2(2), PMM1(1), RDH11(3), SORD(2), TPI1(1)	23117498	37	36	37	13	5	3	6	14	9	0	0.726	1.000	1.000
562	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG10(2), ALG10B(2), ALG12(1), ALG13(3), ALG14(1), ALG3(1), ALG5(1), ALG6(1), ALG8(2), B4GALT3(1), DOLPP1(2), DPAGT1(2), DPM1(1), MAN1A1(2), MAN1A2(1), MAN2A1(2), MGAT4A(2), MGAT4B(1), MGAT5(2), MGAT5B(1), RFT1(1), RPN1(2), RPN2(1), STT3B(2)	25918113	37	36	37	13	0	8	1	18	10	0	0.843	1.000	1.000
563	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(6), AR(1), ESR2(1), ESRRA(2), NR1D2(1), NR1H3(1), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(1), NR2F2(1), NR4A1(1), NR4A2(1), NR5A2(2), PGR(1), PPARD(1), PPARG(1), RARA(4), RARB(2), RORA(1), RXRB(3), RXRG(2), THRA(2), VDR(1)	24907020	39	36	38	12	3	3	11	13	9	0	0.673	1.000	1.000
564	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(3), CALM2(1), GRB2(1), HRAS(1), JUN(2), MAP2K3(9), MAP3K1(5), MAPK14(1), MAPK3(1), PAK1(1), PTK2B(2), RAC1(1), SHC1(2), SOS1(6), SRC(2), SYT1(1)	17464944	39	36	35	16	7	7	1	20	4	0	0.882	1.000	1.000
565	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(1), ERCC3(1), GTF2E2(2), GTF2F2(1), GTF2H1(2), ILK(1), POLR1A(3), POLR1B(2), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLR3B(5), POLR3H(1), POLR3K(1), TAF13(1), TAF5(2), TAF6(1), TBP(1)	21473327	37	36	35	11	0	8	4	16	9	0	0.500	1.000	1.000
566	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BTK(1), CALM2(1), ELK1(1), GRB2(1), HRAS(1), JUN(2), MAP3K1(5), MAPK14(1), MAPK3(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), PPP3CA(1), PPP3CC(1), RAC1(1), SHC1(2), SOS1(6), SYK(1), SYT1(1), VAV1(2)	23043913	38	35	38	19	5	6	4	17	6	0	0.962	1.000	1.000
567	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(7), ARSE(1), ASAH1(1), B4GALT6(1), DEGS1(2), ENPP7(1), GAL3ST1(2), GALC(1), GBA(2), GLB1(4), LCT(2), NEU1(1), PPAP2B(1), PPAP2C(2), SGPP1(1), SGPP2(2), SMPD1(1), SMPD2(2), SPHK2(1), SPTLC1(1), UGT8(2)	21162933	38	35	36	17	6	5	5	15	7	0	0.909	1.000	1.000
568	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	ELK1(1), GRB2(1), HRAS(1), IRS1(3), JUN(2), MAPK3(1), PIK3CA(12), PIK3R1(2), PTPN11(1), RASA1(3), SHC1(2), SOS1(6), SRF(1)	14889071	36	35	33	12	3	13	3	15	2	0	0.502	1.000	1.000
569	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(1), CALM2(1), ELK1(1), GNAI1(1), GNAS(4), GNB1(2), HRAS(1), JUN(2), MAPK3(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), PPP3CA(1), PPP3CC(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), SYT1(1)	20771360	35	34	35	13	5	4	2	19	5	0	0.861	1.000	1.000
570	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AADAC(1), ABAT(1), ACADS(2), AKR1B10(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), BDH1(1), BDH2(1), DDHD1(2), ECHS1(2), EHHADH(3), GAD2(1), HADH(1), HADHA(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), ILVBL(1), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(1), PDHB(1), RDH11(3)	25117682	36	34	35	13	5	4	5	14	8	0	0.790	1.000	1.000
571	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(4), ADH5(1), AKR1B1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), DLAT(2), DLD(2), GRHPR(2), HAGH(1), LDHB(1), LDHC(1), MDH1(1), ME1(1), ME2(2), ME3(2), PC(1), PCK1(4), PDHA1(1), PDHA2(1), PDHB(1), PKM2(1)	22738541	38	34	38	12	0	5	7	14	12	0	0.719	1.000	1.000
572	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(1), ACACA(4), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ECHS1(2), EHHADH(3), HADHA(1), LDHB(1), LDHC(1), MCEE(1), MLYCD(1), MUT(2), PCCA(1), PCCB(2), SUCLG1(5), SUCLG2(1)	20524915	34	33	34	12	2	3	9	13	7	0	0.767	1.000	1.000
573	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(2), EGFR(7), MYC(1), POLR2A(6), PPP2CA(1), RB1(1), TEP1(2), TERT(4), TNKS(1), TP53(10), XRCC5(2)	17383824	37	33	36	12	5	8	7	12	5	0	0.389	1.000	1.000
574	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), AKR1B10(2), G6PC(2), GAA(1), GALE(1), GALK1(1), GALK2(1), GALT(2), GANC(1), GLB1(4), HK1(4), LALBA(1), LCT(2), MGAM(4), PFKL(1), PFKM(2), RDH11(3), UGP2(1)	23600941	35	32	34	12	3	3	6	16	7	0	0.711	1.000	1.000
575	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	20	ELK1(1), GRB2(1), HRAS(1), IL6ST(3), JAK1(4), JAK2(5), JAK3(4), JUN(2), MAPK3(1), PTPN11(1), SHC1(2), SOS1(6), SRF(1), STAT3(1)	14453573	33	32	33	12	2	4	5	17	5	0	0.860	1.000	1.000
576	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(1), DLG4(1), EPHB2(1), F2(3), F2RL1(1), F2RL2(1), JUN(2), MAP2K5(2), PLD1(2), PLD2(2), PLD3(3), PTK2(1), RASAL1(1), SRC(2), TEC(5), VAV1(2)	16974757	30	29	29	12	2	3	5	15	5	0	0.890	1.000	1.000
577	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(3), CXCR4(1), GNAI1(1), GNB1(2), HRAS(1), MAPK3(1), NFKB1(1), PIK3C2G(2), PIK3CA(12), PIK3R1(2), PTK2(1), PTK2B(2), RELA(1)	17319856	30	28	27	15	1	10	3	13	3	0	0.906	1.000	1.000
578	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	CS(2), DLAT(2), DLD(2), DLST(1), IDH3B(1), IDH3G(1), MDH1(1), OGDH(3), PC(1), PDHA1(1), PDHA2(1), PDHB(1), PDHX(1), PDK1(1), PDK2(1), PDK3(1), PDP2(1), SDHA(1), SDHB(1), SDHD(1), SUCLG1(5), SUCLG2(1)	17658030	31	28	31	12	2	3	5	15	6	0	0.842	1.000	1.000
579	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(1), ALDH4A1(1), CAD(4), CPS1(6), EPRS(2), GAD2(1), GFPT1(1), GLS(4), GLS2(2), GOT1(3), GOT2(2), GPT(1), GPT2(1), GSS(1)	20557233	30	27	30	10	1	4	5	14	6	0	0.729	1.000	1.000
580	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(1), AGPS(1), CDS2(1), CHKB(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), ETNK1(2), LCAT(1), LYPLA1(1), PAFAH1B1(1), PAFAH2(1), PCYT1B(1), PISD(1), PLA2G4A(1), PLA2G6(2), PLCB2(2), PLCG2(1), PPAP2B(1), PPAP2C(2)	30852637	29	27	29	12	5	6	3	11	4	0	0.745	1.000	1.000
581	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), ARF3(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(5), CFL1(1), E2F1(1), PRB1(7), TP53(10)	5102483	30	27	29	10	3	3	5	11	8	0	0.606	1.000	1.000
582	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTN1(1), ACTN2(3), ACTN3(1), CAPN1(2), ITGA1(3), ITGB1(3), ITGB3(1), PTK2(1), RAC1(1), SPTAN1(5), SRC(2), TLN1(4)	17808646	27	27	27	11	3	4	1	12	7	0	0.932	1.000	1.000
583	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(1), ARSD(7), ARSE(1), ASAH1(1), GAL3ST1(2), GALC(1), GBA(2), GLB1(4), LCT(2), NEU1(1), PPAP2B(1), PPAP2C(2), SMPD1(1), SMPD2(2), SPTLC1(1)	14356401	29	26	27	14	3	3	4	13	6	0	0.951	1.000	1.000
584	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(2), ADCY3(3), ADCY9(3), ARF1(1), ARF3(1), ARF6(1), ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1D(1), ERO1L(1), GNAS(4), PLCG2(1), SEC61B(1), TRIM23(2)	22897173	27	26	27	15	1	3	4	14	5	0	0.993	1.000	1.000
585	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(2), AP2A1(1), ARF1(1), BTK(1), EEA1(5), GSK3A(2), PFKL(1), PFKM(2), PRKCE(4), PRKCZ(2), RAB5A(1), RAC1(1), RPS6KB1(1), VAV2(4)	15614399	28	26	27	10	1	5	3	12	7	0	0.807	1.000	1.000
586	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(2), ALDOB(3), FBP1(1), FPGT(1), GMPPB(1), HK1(4), KHK(4), MPI(1), PFKFB3(1), PFKM(2), PMM1(1), SORD(2), TPI1(1)	14906325	26	25	26	12	3	2	4	9	8	0	0.917	1.000	1.000
587	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), G6PC(2), GAA(1), GALE(1), GALK1(1), GALK2(1), GALT(2), GLB1(4), HK1(4), LALBA(1), LCT(2), MGAM(4), PFKM(2)	19923975	27	25	26	11	2	2	4	12	7	0	0.886	1.000	1.000
588	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(1), COL4A2(1), COL4A3(4), COL4A4(1), COL4A5(7), COL4A6(4), SLC23A1(4), SLC23A2(1), SLC2A3(3)	16050674	26	25	26	10	3	10	2	8	3	0	0.632	1.000	1.000
589	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL22(1), IL22RA1(1), JAK1(4), JAK2(5), JAK3(4), STAT1(4), STAT3(1), STAT5B(1), TYK2(3)	11362682	24	24	24	12	1	0	4	14	5	0	0.980	1.000	1.000
590	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2A1(1), GTF2F1(1), NCOA1(2), NCOA2(2), NCOA3(5), NCOR2(4), POLR2A(6), RARA(4), TBP(1)	15541685	27	24	27	16	1	4	6	10	6	0	0.961	1.000	1.000
591	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(2), ACE2(1), AGT(1), AGTR1(1), ANPEP(6), CMA1(1), CTSA(1), ENPEP(4), LNPEP(3), MAS1(1), MME(3), REN(1)	13008111	25	23	24	10	1	2	8	12	2	0	0.874	1.000	1.000
592	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	31	ANPEP(6), G6PD(2), GGT1(2), GPX3(2), GPX4(1), GPX5(1), GSS(1), GSTA3(1), GSTA4(1), GSTM1(1), GSTM5(1), IDH1(2), MGST3(2)	11232717	23	22	22	10	2	0	6	10	5	0	0.956	1.000	1.000
593	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(1), AGT(1), AGTR1(1), CMA1(1), COL4A1(1), COL4A2(1), COL4A3(4), COL4A4(1), COL4A5(7), COL4A6(4), REN(1)	16040168	23	21	23	10	3	9	1	6	4	0	0.786	1.000	1.000
594	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(1), ACTN2(3), ACTN3(1), BCAR1(3), CSK(2), CTNNA1(2), CTNNA2(4), CTNNB1(1), PTK2(1), SRC(2), VCL(2)	11855282	22	21	22	12	4	4	1	10	3	0	0.966	1.000	1.000
595	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(3), GNAI1(1), GNB1(2), HRAS(1), ITGA1(3), ITGB1(3), MAPK3(1), PLA2G4A(1), PLCB1(1), PTGS1(1), PTK2(1), SRC(2), SYK(1), TBXAS1(1)	15086673	22	21	22	13	2	3	3	7	7	0	0.979	1.000	1.000
596	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(6), ASAH1(1), EPHB2(1), ITPKA(1), ITPKB(2), JUN(2), MAP2K7(1), MAPK10(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2)	17169842	21	21	21	10	4	2	3	10	2	0	0.867	1.000	1.000
597	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA3(1), ANXA4(1), ANXA6(1), CYP11A1(1), EDNRB(1), HPGD(1), PLA2G4A(1), PTGDR(1), PTGDS(1), PTGER2(1), PTGER4(1), PTGFR(2), PTGIR(1), PTGS1(1), PTGS2(4), TBXAS1(1)	12538726	20	20	20	12	1	3	3	8	5	0	0.971	1.000	1.000
598	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(2), CASP1(1), CASP7(1), INSR(3), MAGI1(2), MAGI2(4), RERE(3), WWP2(2)	14624161	18	18	17	13	3	2	2	7	4	0	0.998	1.000	1.000
599	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CFL1(1), GNAS(4), GNB1(2), HRAS(1), MAPK3(1), MYL2(1), NOX1(2), PIK3C2G(2), PLCB1(1), PTK2(1), ROCK2(3)	15794685	19	17	19	11	1	2	0	12	4	0	0.993	1.000	1.000
600	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(1), GALNT10(1), GALNT2(1), GALNT6(1), GALNT7(5), GALNT9(1), GCNT1(2), ST3GAL1(1), WBSCR17(4)	9070518	17	17	17	11	0	1	6	6	4	0	0.993	1.000	1.000
601	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(1), PAFAH1B1(1), PAFAH2(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLD1(2), PLD2(2), PPAP2B(1), PPAP2C(2)	14415375	17	16	17	9	1	2	4	10	0	0	0.912	1.000	1.000
602	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM2(1), CDKN1A(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(4), PPP3CA(1), PPP3CC(1), SP3(1), SYT1(1)	12257733	15	15	15	11	2	3	2	5	3	0	0.992	1.000	1.000
603	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(1), CCL2(1), CCR5(3), CXCR4(1), JUN(2), MAPK14(1), PTK2B(2), SYT1(1)	8428473	12	10	11	7	1	3	1	7	0	0	0.930	1.000	1.000
604	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(6), NRG2(2), NRG3(2)	5666673	10	10	10	5	1	3	0	6	0	0	0.850	1.000	1.000
605	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(1), ACOX3(2), FADS2(2), PLA2G12A(1), PLA2G4A(1), PLA2G6(2)	6430723	9	9	9	5	2	1	2	4	0	0	0.805	1.000	1.000
606	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	BID(1), BIRC2(3), BIRC3(2), CASP7(1)	8384011	7	7	7	4	0	2	1	4	0	0	0.862	1.000	1.000
607	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(2), SDHA(1), SDHB(1), SDHD(1)	4061439	5	5	5	3	2	0	1	2	0	0	0.875	1.000	1.000
608	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(1), NR1H3(1), NR1H4(1)	3221997	3	3	3	3	0	1	0	2	0	0	0.974	1.000	1.000
609	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(1), PTK2B(2)	4134066	3	3	3	6	0	2	0	1	0	0	0.997	1.000	1.000
610	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(1), SNCAIP(1), UBE2E2(1)	3943564	3	3	3	3	0	2	1	0	0	0	0.906	1.000	1.000
611	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	RB1(1), SP3(1)	4177849	2	2	2	2	0	2	0	0	0	0	0.962	1.000	1.000
612	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	LPL(1), PPARG(1)	3394881	2	2	2	2	1	1	0	0	0	0	0.902	1.000	1.000
613	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	TPI1(1)	993669	1	1	1	2	0	0	1	0	0	0	0.982	1.000	1.000
614	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(1)	1301999	1	1	1	2	0	0	0	1	0	0	0.989	1.000	1.000
615	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1		316078	0	0	0	1	0	0	0	0	0	0	1.000	1.000	1.000
616	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4		3004629	0	0	0	3	0	0	0	0	0	0	1.000	1.000	1.000
