rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(18), AKT1(1), ATM(8), BAX(1), CDKN1A(2), CPB2(3), CSNK1A1(2), CSNK1D(2), FHL2(1), GADD45A(1), HIF1A(1), IGFBP3(2), MAPK8(3), MDM2(2), NFKBIB(1), TP53(147)	5514084	195	151	146	10	27	58	18	40	50	2	2.80e-10	<1.00e-15	<1.50e-13
2	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(17), DAXX(3), HRAS(5), PAX3(4), RARA(1), RB1(12), SIRT1(1), SP100(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TP53(147)	5020302	197	147	147	17	17	59	21	42	58	0	7.74e-08	<1.00e-15	<1.50e-13
3	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(8), CDC25B(2), CDC25C(1), CHEK1(5), MYT1(4), RB1(12), TP53(147), WEE1(4)	4677103	183	146	134	10	18	53	19	36	57	0	9.29e-09	<1.00e-15	<1.50e-13
4	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	IFNG(1), IFNGR1(4), IFNGR2(1), IKBKB(2), JAK2(4), LIN7A(1), NFKB1(2), RB1(12), RELA(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TP53(147), USH1C(7), WT1(4)	4825619	192	144	143	16	19	51	21	43	58	0	1.07e-07	<1.00e-15	<1.50e-13
5	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(8), ATR(13), CDC25C(1), CHEK1(5), CHEK2(3), TP53(147)	4260894	177	146	128	10	18	52	20	37	50	0	2.15e-07	1.22e-15	1.50e-13
6	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	ARF1(1), CCND1(1), CDKN1A(2), CDKN2A(26), CFL1(2), E2F1(2), MDM2(2), NXT1(1), PRB1(5), TP53(147)	2143952	189	149	137	12	18	56	19	37	59	0	2.48e-10	2.22e-15	2.05e-13
7	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(3), CDKN2A(26), E2F1(2), MDM2(2), MYC(1), PIK3CA(29), PIK3R1(2), POLR1A(3), POLR1B(2), POLR1D(1), RAC1(1), RB1(12), TBX2(3), TP53(147), TWIST1(1)	5361306	235	155	170	19	43	60	19	44	69	0	1.72e-09	2.55e-15	2.05e-13
8	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(2), EIF2S2(1), MAP3K14(1), NFKB1(2), RELA(3), TP53(147)	2611540	156	141	107	10	11	43	18	34	50	0	1.74e-07	2.66e-15	2.05e-13
9	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(3), ATM(8), ATR(13), CCNA1(1), CCND1(1), CCNE1(3), CDKN1A(2), CDKN2A(26), CDKN2B(1), E2F1(2), HDAC1(2), RB1(12), SKP2(2), TFDP1(3), TGFB1(1), TGFB2(3), TP53(147)	7994705	230	156	178	17	29	69	22	40	70	0	2.61e-09	3.00e-15	2.05e-13
10	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(4), ATM(8), BAX(1), CCND1(1), CCNE1(3), CDKN1A(2), E2F1(2), GADD45A(1), MDM2(2), RB1(12), TP53(147)	4817072	183	149	134	8	17	53	18	38	57	0	4.33e-10	3.77e-15	2.11e-13
11	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(1), EGFR(7), IGF1R(1), MYC(1), POLR2A(2), PRKCA(5), RB1(12), TEP1(8), TERF1(3), TERT(3), TNKS(7), TP53(147), XRCC5(2)	7492174	199	149	149	17	24	56	18	42	59	0	1.35e-08	3.77e-15	2.11e-13
12	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(2), MYC(1), SP1(2), SP3(1), TP53(147), WT1(4)	1863398	157	146	108	12	10	45	19	36	47	0	8.63e-07	4.55e-15	2.34e-13
13	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(3), ATM(8), BRCA1(12), CDKN1A(2), CHEK1(5), CHEK2(3), GADD45A(1), JUN(3), MAPK8(3), MDM2(2), MRE11A(1), NFKB1(2), RAD50(3), RAD51(1), RBBP8(1), RELA(3), TP53(147)	7908840	200	144	150	16	28	56	19	42	55	0	5.26e-07	1.55e-14	7.37e-13
14	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	CREB1(1), FOS(2), JUN(3), KEAP1(24), MAPK1(1), MAPK14(1), MAPK8(3), NFE2L2(28), PRKCA(5)	2338729	68	60	51	3	36	18	3	7	4	0	1.89e-05	8.13e-13	3.58e-11
15	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(1), APAF1(4), ATM(8), BAX(1), BCL2L1(1), CASP7(2), CASP9(3), PRKCA(5), PTK2(6), PXN(3), STAT1(2), TLN1(6), TP53(147)	7279788	189	149	139	20	25	54	21	40	49	0	1.49e-05	6.12e-11	2.51e-09
16	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(8), ATR(13), BRCA1(12), CCNB1(2), CDC25B(2), CDC25C(1), CDKN1A(2), CHEK1(5), CHEK2(3), EP300(9), GADD45A(1), MDM2(2), MYT1(4), PRKDC(12), RPS6KA1(2), TP53(147), WEE1(4), YWHAQ(1)	11278058	230	152	180	19	32	71	23	47	57	0	5.33e-08	2.48e-10	9.56e-09
17	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(1), CCNA2(1), CCND1(1), CCNE1(3), CCNE2(2), CDKN2A(26), E2F1(2), PRB1(5)	2289648	41	39	38	2	11	12	3	2	13	0	0.00147	1.54e-05	0.000557
18	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(3), CKS1B(1), CUL1(4), E2F1(2), RB1(12), RBX1(1), SKP2(2), TFDP1(3), UBE2M(1)	2280104	29	27	29	1	6	10	0	3	10	0	0.00869	0.00920	0.315
19	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(3), CUL1(4), E2F1(2), FBXW7(11), RB1(12), TFDP1(3)	2194468	35	34	33	4	7	10	3	2	13	0	0.0913	0.0138	0.448
20	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(1), CCNB1(2), CCND1(1), CCND2(3), CCND3(1), CCNE1(3), CDK7(1), CDKN1A(2), CDKN2A(26), CDKN2B(1), CDKN2C(1), E2F1(2), RB1(12), RBL1(5), TFDP1(3)	4229528	64	54	61	5	14	15	5	7	23	0	0.00238	0.0172	0.530
21	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(1), CCNE1(3), CUL1(4), E2F1(2), RB1(12), SKP2(2), TFDP1(3)	2267909	27	25	27	1	7	9	0	2	9	0	0.0107	0.0261	0.766
22	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(3)	134908	3	3	3	1	0	1	0	2	0	0	0.809	0.0409	1.000
23	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(8), ATR(13), BRCA1(12), BRCA2(12), CHEK1(5), CHEK2(3), FANCA(5), FANCC(2), FANCF(3), FANCG(3), MRE11A(1), RAD1(2), RAD17(2), RAD50(3), RAD51(1), RAD9A(2), TP53(147), TREX1(1)	11712417	225	149	176	24	36	61	22	49	57	0	2.42e-05	0.0827	1.000
24	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYB(1), RB1(12), SP1(2), SP3(1)	1763653	17	17	17	1	1	5	0	2	9	0	0.119	0.0935	1.000
25	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(9), CYP2C9(3)	536360	12	10	12	3	5	4	0	2	1	0	0.484	0.101	1.000
26	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(1), CCND1(1), CCNE1(3), CDKN1A(2), E2F1(2), HRAS(5), MAPK1(1), MAPK3(1), NFKB1(2), PAK1(2), PIK3CA(29), PIK3R1(2), RAC1(1), RAF1(1), RB1(12), RELA(3), TFDP1(3)	5363789	71	58	57	6	30	16	2	13	10	0	0.000660	0.181	1.000
27	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(1), AKT3(3), BPNT1(1), ILK(2), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(29), PIK3CD(4), PTEN(16), RBL2(8), SHC1(2), SOS1(11)	5402509	80	64	66	8	33	16	1	18	12	0	0.00130	0.204	1.000
28	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(3), CYP11A1(2), CYP11B1(15), CYP11B2(7), CYP17A1(2), CYP21A2(2), HSD11B1(3), HSD11B2(1), HSD3B1(6), HSD3B2(3)	2339282	45	40	45	7	9	22	1	12	1	0	0.0158	0.240	1.000
29	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(1), AKR1D1(3), CYP11A1(2), CYP11B1(15), CYP11B2(7), CYP17A1(2), CYP21A2(2), HSD11B1(3), HSD11B2(1), HSD3B1(6), HSD3B2(3)	2339282	45	40	45	7	9	22	1	12	1	0	0.0158	0.240	1.000
30	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25B(2), CDK7(1), CDKN1A(2), CHEK1(5), NEK1(3), WEE1(4)	1849805	17	17	17	1	7	5	1	3	1	0	0.101	0.245	1.000
31	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(13), PDXP(1), PSAT1(3)	1279971	17	16	17	2	6	5	0	5	1	0	0.134	0.282	1.000
32	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(2)	191569	2	2	2	0	0	1	0	0	1	0	0.503	0.358	1.000
33	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(4), PGLYRP2(2)	477868	6	5	6	0	1	4	1	0	0	0	0.150	0.372	1.000
34	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(2), HLCS(5), SPCS1(1), SPCS3(2)	816418	10	9	10	2	2	2	2	0	4	0	0.402	0.492	1.000
35	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(7), GABRA2(13), GABRA3(4), GABRA4(5), GABRA5(6), GABRA6(8), PRKCE(3)	2092435	46	38	46	9	5	18	6	11	6	0	0.180	0.494	1.000
36	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(3), FOS(2), HRAS(5), IGF1(3), IGF1R(1), IRS1(7), JUN(3), MAP2K1(2), MAPK3(1), MAPK8(3), PIK3CA(29), PIK3R1(2), PTPN11(3), RAF1(1), RASA1(8), SHC1(2), SOS1(11), SRF(2)	6550634	88	69	73	8	38	26	2	12	10	0	0.000158	0.514	1.000
37	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	CREB1(1), HBXIP(1), HRAS(5), SHC1(2), SOS1(11)	2332935	20	19	19	1	3	9	2	4	2	0	0.0289	0.532	1.000
38	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(6), GOT2(3), TAT(1), TYR(10)	1245159	20	18	20	4	2	12	0	3	3	0	0.215	0.535	1.000
39	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(1), IFNG(1), IL12A(1), IL12B(3)	791855	6	6	6	1	3	1	0	0	2	0	0.523	0.540	1.000
40	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(1), GH1(2), GHR(3), HRAS(5), IGF1(3), IGF1R(1), PIK3CA(29), PIK3R1(2), SHC1(2), SOD2(1)	3519496	49	42	35	6	26	15	2	6	0	0	0.0129	0.570	1.000
41	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(1), BCAR1(6), ILK(2), ITGB1(5), MAPK1(1), MAPK3(1), PDK2(2), PDPK1(1), PIK3CA(29), PIK3R1(2), PTEN(16), PTK2(6), SHC1(2), SOS1(11)	5104711	85	65	71	10	34	19	2	19	11	0	0.00515	0.585	1.000
42	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(2), ASL(4), CPS1(30), GLS(4), GLUD1(4)	2063965	44	37	43	7	6	22	2	10	4	0	0.0722	0.626	1.000
43	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(2), SUCLA2(2)	557526	4	4	4	0	1	1	0	2	0	0	0.314	0.638	1.000
44	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(3), PLCD1(1), PRKCA(5), TGM2(1)	1305943	10	10	10	1	2	3	1	3	1	0	0.236	0.686	1.000
45	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDFT1(1), FDPS(1), GGPS1(2), IDI1(1), IDI2(2), SQLE(3)	1145747	10	9	10	0	3	3	0	4	0	0	0.0725	0.693	1.000
46	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(1), HRAS(5), IGF1R(1), IRS1(7), MAP2K1(2), MAPK1(1), MAPK3(1), PIK3CA(29), PIK3R1(2), RAF1(1), SHC1(2), SOS1(11)	5026832	63	52	49	6	27	20	2	11	3	0	0.00138	0.705	1.000
47	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(2), ACADM(1), ACADS(2), ACAT1(2), ECHS1(1), HADHA(2)	1439001	10	10	10	1	0	4	1	3	2	0	0.267	0.720	1.000
48	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(1), TGDS(1), UGDH(2), UXS1(4)	1040874	8	7	8	1	4	1	0	2	1	0	0.348	0.724	1.000
49	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(3)	453710	3	3	3	1	0	2	1	0	0	0	0.744	0.736	1.000
50	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDFT1(1), FDPS(1), IDI1(1), SQLE(3)	859199	6	6	6	0	1	2	0	3	0	0	0.207	0.756	1.000
51	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD3D(1), CD80(3), CD86(3), CTLA4(1), HLA-DRA(1), HLA-DRB1(2), ICOS(2), ITK(2), LCK(3), PIK3CA(29), PIK3R1(2), PTPN11(3)	3390321	52	45	39	8	29	7	2	10	4	0	0.0589	0.761	1.000
52	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCR3(1), HLA-DRA(1), HLA-DRB1(2), IL3(1)	804618	5	5	5	0	2	1	0	0	2	0	0.263	0.768	1.000
53	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	ASNS(5), CA12(2), CA14(1), CA3(4), CA4(1), CA5A(2), CA5B(2), CA6(2), CA7(3), CA9(1), CPS1(30), GLS(4), GLS2(1), GLUD1(4), GLUL(4), HAL(2)	5030899	68	51	67	8	15	31	3	14	5	0	0.00227	0.804	1.000
54	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(1), TGDS(1), UGDH(2), UGP2(4), UXS1(4)	1319800	12	11	12	2	5	2	0	3	2	0	0.351	0.810	1.000
55	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(1)	302729	1	1	1	0	0	0	0	1	0	0	0.787	0.824	1.000
56	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	FUT2(1), FUT3(3), FUT5(4), FUT6(2)	1347433	10	9	10	2	0	5	4	1	0	0	0.297	0.826	1.000
57	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD4(1), CD80(3), HLA-DRA(1), HLA-DRB1(2), IL10(2), IL4(2)	1054491	11	10	11	3	4	1	1	3	2	0	0.512	0.848	1.000
58	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(4), GLS2(1), GLUD1(4), GLUD2(9)	1203525	18	17	18	4	5	7	0	3	3	0	0.453	0.850	1.000
59	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	MTMR1(1), MTMR2(2), MTMR6(5), NFS1(2), TPK1(5)	1697224	15	14	15	2	5	5	1	3	1	0	0.243	0.851	1.000
60	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCR3(1), CD4(1), HLA-DRA(1), HLA-DRB1(2), IL1B(1), IL4(2), IL5RA(3), IL6(1)	1418962	12	11	12	2	2	6	0	1	3	0	0.271	0.855	1.000
61	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(1), PIK3CA(29), PIK3R1(2), PLCB1(8), PLCG1(3), PRKCA(5), VAV1(7)	3403944	55	47	42	9	32	13	2	7	1	0	0.0688	0.873	1.000
62	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(2), CBS(4), MUT(4)	1293204	10	9	10	0	3	4	0	1	2	0	0.0668	0.877	1.000
63	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(4), ATM(8), ATR(13), BAI1(11), BAX(1), CASP8(2), CASP9(3), CCNB1(2), CCNB2(1), CCNB3(11), CCND1(1), CCND2(3), CCND3(1), CCNE1(3), CCNE2(2), CCNG1(1), CD82(2), CDKN1A(2), CDKN2A(26), CHEK1(5), CHEK2(3), DDB2(3), EI24(1), FAS(1), GADD45A(1), GADD45B(1), GADD45G(1), GTSE1(4), IGF1(3), IGFBP3(2), LRDD(1), MDM2(2), PPM1D(1), PTEN(16), RFWD2(5), RPRM(1), RRM2(1), RRM2B(3), SERPINB5(2), SESN1(3), SESN2(2), SESN3(3), SFN(2), SIAH1(1), STEAP3(2), THBS1(1), TNFRSF10B(1), TP53(147), TSC2(5)	17283296	321	163	267	37	61	91	31	55	83	0	1.95e-08	0.915	1.000
64	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ERBB4(13), NRG2(3), NRG3(9), PRKCA(5), PSEN1(3)	2379756	33	31	33	6	7	12	3	4	7	0	0.225	0.935	1.000
65	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ARPC1A(4), CDC42(1), PAK1(2), PDGFRA(10), PIK3CA(29), PIK3R1(2), RAC1(1), WASL(2)	3550818	51	43	37	7	31	11	1	8	0	0	0.0457	0.949	1.000
66	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD4(1), HLA-DRA(1), HLA-DRB1(2)	632428	4	4	4	2	2	0	0	0	2	0	0.783	0.956	1.000
67	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(3), FOS(2), HRAS(5), INSR(10), IRS1(7), JUN(3), MAP2K1(2), MAPK3(1), MAPK8(3), PIK3CA(29), PIK3R1(2), PTPN11(3), RAF1(1), RASA1(8), SHC1(2), SLC2A4(2), SOS1(11), SRF(2)	6731065	96	72	81	11	39	28	2	15	12	0	0.000405	0.959	1.000
68	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT2(3), TAT(1)	695155	4	4	4	2	1	2	0	1	0	0	0.812	0.964	1.000
69	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(2), EPHX2(3), RDH11(1), RDH12(2), RDH13(1)	1272837	9	8	9	2	2	3	0	3	1	0	0.403	0.978	1.000
70	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(1), TPI1(3)	431229	4	4	4	2	2	1	0	1	0	0	0.841	0.978	1.000
71	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(1), HRAS(5), KLK2(2), NTRK1(4), PIK3CA(29), PIK3R1(2), PLCG1(3), PRKCA(5), SHC1(2), SOS1(11)	4134481	64	50	50	10	30	17	3	9	5	0	0.0333	0.979	1.000
72	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(8), GOT2(3), LDHB(3), LDHC(3)	1794526	17	16	17	4	3	4	1	7	2	0	0.453	0.980	1.000
73	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	CASP8(2), CFL1(2), CFLAR(2)	1021642	6	6	6	2	1	2	0	1	2	0	0.725	0.981	1.000
74	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(2), ACO2(3), AFMID(1), GRHPR(2), HAO1(7), MDH1(1), MDH2(1), MTHFD1(4), MTHFD1L(2), MTHFD2(4)	3548938	27	25	27	4	10	8	1	4	4	0	0.0735	0.984	1.000
75	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(1), GSTZ1(2), HGD(4)	595240	7	7	7	4	2	3	0	1	1	0	0.889	0.984	1.000
76	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(2), CD3D(1), CD4(1)	856259	4	4	4	3	0	1	0	1	2	0	0.941	0.984	1.000
77	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(2), ACOX3(5), FADS2(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5)	2697863	30	27	30	6	8	11	6	0	5	0	0.160	0.986	1.000
78	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(1), GRIA2(7), JUND(2), PPP1R1B(1)	995583	11	9	11	7	1	5	1	1	3	0	0.926	0.986	1.000
79	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(2), ACO2(3), GRHPR(2), HAO1(7), MDH1(1), MDH2(1), MTHFD1(4), MTHFD1L(2), MTHFD2(4)	3388767	26	24	26	4	10	8	1	4	3	0	0.0893	0.987	1.000
80	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(2), CLOCK(5), CRY1(3), CRY2(2), PER1(6)	2232341	18	16	18	3	5	6	3	3	1	0	0.253	0.987	1.000
81	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	ACAT1(2), CSF1(2), IL6(1), LDLR(4), LPL(3)	1412543	12	12	12	3	5	6	0	1	0	0	0.422	0.989	1.000
82	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(3), CHAT(9), CHKA(4), PDHA1(3), PDHA2(8), SLC18A3(8)	1839111	35	30	35	9	7	14	4	9	1	0	0.272	0.993	1.000
83	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(3), NDUFB5(2), NDUFB6(1), NDUFB7(2), NDUFS1(4), NDUFV1(2), NDUFV2(2)	1837039	16	15	16	4	3	4	4	3	2	0	0.553	0.994	1.000
84	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	JAK1(2), JAK2(4), JAK3(7), PIAS1(5), PIAS3(3), PTPRU(7), REG1A(12), SOAT1(1)	3656481	41	32	41	8	13	9	5	10	4	0	0.147	0.994	1.000
85	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(2), DHRS2(2), DHRSX(4), PON1(7), PON2(1), PON3(1), RDH11(1), RDH12(2), RDH13(1)	2386466	21	17	21	4	6	5	1	7	2	0	0.192	0.995	1.000
86	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(3), FOS(2), HRAS(5), JUN(3), KLK2(2), MAP2K1(2), MAPK3(1), MAPK8(3), NGFR(1), PIK3CA(29), PIK3R1(2), PLCG1(3), RAF1(1), SHC1(2), SOS1(11)	5061371	70	55	55	10	36	19	2	11	2	0	0.0131	0.996	1.000
87	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(3), FOS(2), HRAS(5), JAK2(4), JUN(3), MAP2K1(2), MAPK3(1), MPL(2), PIK3CA(29), PIK3R1(2), PLCG1(3), PRKCA(5), RAF1(1), RASA1(8), SHC1(2), SOS1(11), STAT1(2), STAT3(2), STAT5A(2)	7920539	89	69	74	11	39	19	5	14	12	0	0.00352	0.996	1.000
88	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMPR1A(3), BMPR1B(1), BMPR2(1)	1652105	5	5	5	1	0	2	1	2	0	0	0.581	0.996	1.000
89	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(8), CDC25B(2), CDC25C(1), CHEK1(5), MYT1(4), WEE1(4)	3662407	24	22	24	3	8	9	2	3	2	0	0.147	0.997	1.000
90	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(4), APOBEC1(7), APOBEC2(2), APOBEC3F(1), APOBEC4(3)	1951950	17	16	17	4	3	7	0	4	3	0	0.453	0.997	1.000
91	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	ASNS(5), CA12(2), CA13(1), CA14(1), CA3(4), CA4(1), CA5A(2), CA5B(2), CA6(2), CA7(3), CA9(1), CPS1(30), GLS(4), GLS2(1), GLUD1(4), GLUD2(9), GLUL(4), HAL(2)	5626259	78	57	77	11	18	36	3	14	7	0	0.00459	0.997	1.000
92	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(11), GGT1(1)	1104238	12	10	12	5	2	3	3	2	2	0	0.725	0.997	1.000
93	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	FABP6(1), LDLR(4), NR0B2(1), NR1H3(2), NR1H4(8), RXRA(2)	1443617	18	18	18	5	6	4	1	4	3	0	0.516	0.998	1.000
94	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(3), ADORA2A(5), ADORA3(1), P2RY1(3), P2RY2(3), P2RY6(2)	1574980	17	14	17	5	4	9	1	2	1	0	0.203	0.998	1.000
95	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	DLL1(1), FURIN(1), NOTCH1(18), PSEN1(3)	2426479	23	19	23	9	1	9	1	4	8	0	0.719	0.998	1.000
96	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GSR(4), GSS(2), NFKB1(2), NOX1(2), RELA(3), TNF(1), XDH(11)	2642844	25	19	25	5	5	11	2	4	3	0	0.177	0.999	1.000
97	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(2), F13B(13), HSD17B1(1), HSD17B4(1), HSD17B7(1), HSD3B1(6), HSD3B2(3)	2147171	27	24	27	7	10	8	1	7	1	0	0.393	0.999	1.000
98	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	FUT2(1), FUT9(5), GBGT1(2), GLA(2), HEXA(5), NAGA(1), ST3GAL1(4), ST3GAL4(2), ST8SIA1(3)	2683176	25	21	25	5	7	9	1	7	1	0	0.174	0.999	1.000
99	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(2), FOSL1(1), FOSL2(1), IFNAR1(2), IFNB1(2), MAPK8(3), NFKB1(2), RELA(3), TNFRSF11A(2), TNFSF11(1), TRAF6(5)	2940852	24	20	24	4	10	10	1	1	2	0	0.208	0.999	1.000
100	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(1), AASDHPPT(1), AASS(11), KARS(3)	1250104	16	13	16	5	2	9	1	2	2	0	0.709	0.999	1.000
101	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(3), PARK2(10), SNCAIP(3), UBE2E2(2), UBE2G1(1), UBE2G2(1), UBE2L6(1)	1698416	21	20	21	5	5	3	3	6	4	0	0.465	0.999	1.000
102	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(3), EGF(6), EGFR(7), HGS(3), TF(6), TFRC(2)	3406063	27	24	26	4	10	10	0	5	2	0	0.143	0.999	1.000
103	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(2), CD3D(1), GZMB(1), HLA-A(7), ICAM1(2), ITGAL(1), ITGB2(5), PRF1(2)	2307379	21	19	21	9	4	5	0	6	5	1	0.682	0.999	1.000
104	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	CNR1(5), CNR2(2), DNMT1(4), MTNR1A(1), MTNR1B(10), PTAFR(3), PTGDR(6), PTGER2(2), PTGER4(2), PTGFR(5), PTGIR(1), TBXA2R(2)	2950758	43	38	43	10	9	18	4	11	1	0	0.102	0.999	1.000
105	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(18), ABCB11(6), ABCB4(8), ABCC1(5), ABCC3(3), GSTP1(1)	3806542	41	29	41	9	14	15	5	5	1	1	0.0977	0.999	1.000
106	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(2), CYP11A1(2), CYP11B2(7), CYP17A1(2), HSD11B1(3), HSD11B2(1), HSD3B1(6), HSD3B2(3)	1839040	26	23	26	8	6	11	0	8	1	0	0.362	0.999	1.000
107	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	ECHS1(1), EHHADH(1), HADHA(2), SDS(2)	1289139	6	6	6	7	1	1	1	1	2	0	0.995	0.999	1.000
108	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(1), CHPT1(1), LCMT1(2), LCMT2(1), METTL2B(1), METTL6(2), PCYT1B(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), WBSCR22(3)	3725202	31	27	31	5	7	13	2	3	6	0	0.0839	1.000	1.000
109	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(1), DCN(1), FMOD(2), LUM(2)	963183	6	6	5	3	3	3	0	0	0	0	0.725	1.000	1.000
110	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	IL6(1), IL6R(1), JAK1(2), JAK2(4), JAK3(7), PIAS3(3), PTPRU(7), REG1A(12), STAT3(2)	4044532	39	32	39	8	12	10	5	7	5	0	0.143	1.000	1.000
111	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2)	2110033	12	11	12	3	3	8	0	0	1	0	0.370	1.000	1.000
112	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2)	2110033	12	11	12	3	3	8	0	0	1	0	0.370	1.000	1.000
113	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CD36(1), FOS(2), FYN(5), JUN(3), MAPK14(1), THBS1(1)	1948766	13	11	12	3	6	2	1	4	0	0	0.489	1.000	1.000
114	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH7(1), ADHFE1(2)	1495071	9	9	9	3	2	6	0	1	0	0	0.684	1.000	1.000
115	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(2), ALDH18A1(3), ARG1(2), ASL(4), CKM(2), CKMT2(3), CPS1(30), GATM(1), GLUD1(4), NAGS(1), OAT(1), ODC1(1), OTC(3), PYCR1(1), SMS(2)	4623209	60	47	59	10	12	24	4	11	9	0	0.0260	1.000	1.000
116	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	FUT2(1), FUT9(5), GCNT2(2), ST8SIA1(3)	1627540	11	11	11	4	3	3	0	4	1	0	0.707	1.000	1.000
117	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(1), DHRS2(2), DHRSX(4), LCMT1(2), LCMT2(1), METTL2B(1), METTL6(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), WBSCR22(3)	3971100	34	29	34	6	10	13	2	3	6	0	0.0759	1.000	1.000
118	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(3), ARG1(2), GLS(4), GLUD1(4), OAT(1), PRODH(1)	1468000	15	14	15	6	2	6	0	5	2	0	0.833	1.000	1.000
119	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A2(4), BCMO1(2), RDH5(1)	1031666	7	7	7	4	2	4	0	0	1	0	0.865	1.000	1.000
120	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	GBA(4), GBA3(11), GGT1(1)	1473049	16	14	16	6	3	4	4	3	2	0	0.687	1.000	1.000
121	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(1), IFNGR1(4), IFNGR2(1), JAK1(2), JAK2(4), STAT1(2)	2175126	14	13	14	4	7	1	2	2	2	0	0.659	1.000	1.000
122	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(1), AASDH(6), AASDHPPT(1), AASS(11), KARS(3)	1845412	22	18	22	7	3	9	2	5	3	0	0.749	1.000	1.000
123	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(5), GBA3(11), LPO(2), MPO(4), PRDX1(1), PRDX6(2), TPO(10), TYR(10)	2553458	45	37	45	11	9	18	7	7	4	0	0.197	1.000	1.000
124	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(2), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(2), POLRMT(2)	3554341	15	14	15	2	4	5	0	2	4	0	0.152	1.000	1.000
125	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(2), ACP2(1), ACPT(2), ENPP1(8), ENPP3(6), FLAD1(2), TYR(10)	2541512	31	25	31	9	4	17	3	1	6	0	0.510	1.000	1.000
126	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(1), AKT3(3), CDKN1A(2), HRAS(5), MAP2K1(2), MAP2K2(1), NGFR(1), NTRK1(4), PIK3CA(29), PIK3CD(4), SHC1(2), SOS1(11)	4288230	65	52	51	13	27	22	2	10	4	0	0.0611	1.000	1.000
127	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(3), GPD2(2), SDHA(3), SDHB(2)	1754928	10	9	10	3	5	2	0	2	1	0	0.646	1.000	1.000
128	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(1), HADH(1), HADHA(2), HADHB(3), HSD17B4(1), PPT1(1), PPT2(1)	2245979	11	11	11	3	4	3	0	2	2	0	0.552	1.000	1.000
129	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(2), ACO2(3), FH(2), IDH1(2), MDH1(1), MDH2(1), SDHB(2), SUCLA2(2)	2360197	15	14	15	4	5	6	1	1	2	0	0.495	1.000	1.000
130	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNB1(2), JAK1(2), PTPRU(7), REG1A(12), STAT1(2), STAT2(1), TYK2(8)	3304772	36	32	36	9	12	11	5	3	5	0	0.273	1.000	1.000
131	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	IFNG(1), IFNGR1(4), JAK1(2), JAK2(4), PLA2G2A(1), PTPRU(7), REG1A(12), STAT1(2)	3036479	33	28	33	8	14	4	6	5	4	0	0.403	1.000	1.000
132	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	CPOX(2), FECH(2), PPOX(1), UROD(1), UROS(1)	2007489	7	7	7	2	3	3	0	0	1	0	0.566	1.000	1.000
133	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(1), CD34(2), CD3D(1), CD4(1), CD58(1), CD8A(2), IL3(1), IL6(1)	1650191	10	9	10	6	1	4	0	3	2	0	0.924	1.000	1.000
134	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(1), BIRC3(3), CASP8(2), FADD(1), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1)	2226973	12	10	12	6	4	3	1	0	4	0	0.859	1.000	1.000
135	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CSF1(2), IL1B(1), MST1(2), MST1R(3), TNF(1)	1722648	9	9	9	3	3	5	0	1	0	0	0.549	1.000	1.000
136	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(8), CARS2(1), GOT2(3), LDHAL6A(2), LDHAL6B(1), LDHB(3), LDHC(3), SDS(2), SULT1B1(4), SULT1C2(4), SULT1C4(1)	3303954	32	25	32	7	11	5	4	9	3	0	0.309	1.000	1.000
137	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	12	CPO(1), FECH(2), GATA1(3), HBB(2), UROD(1), UROS(1)	2078525	10	10	10	3	2	5	0	1	2	0	0.542	1.000	1.000
138	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(19), GNA12(2), PRKACB(3), PRKACG(1), PRKAR2B(3)	2666246	28	25	28	6	8	13	0	6	1	0	0.280	1.000	1.000
139	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(2), GAD1(5), HDC(6), PNMT(2), TH(2), TPH1(2)	1589560	19	18	19	6	6	10	1	1	1	0	0.402	1.000	1.000
140	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(5), MMP14(2), MMP2(3), MMP9(5), RECK(3), TIMP2(1), TIMP4(1)	1987015	20	17	19	5	2	13	2	2	1	0	0.353	1.000	1.000
141	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(1), CD8A(2), CSF1(2), IL3(1), IL4(2), IL6(1), IL7(1)	1620210	10	9	10	7	0	6	0	2	2	0	0.931	1.000	1.000
142	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(3), PLCG1(3), PRKCA(5)	1778924	11	11	11	4	3	4	2	1	1	0	0.706	1.000	1.000
143	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	FUT2(1), FUT9(5), GBGT1(2), GLA(2), HEXA(5), NAGA(1), ST3GAL1(4), ST8SIA1(3)	2848570	23	20	23	5	6	9	1	6	1	0	0.213	1.000	1.000
144	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(2), GPI(5), HK1(2), PFKL(2), PGK1(2), PKLR(4), TPI1(3)	2444355	20	16	20	6	5	8	0	3	4	0	0.344	1.000	1.000
145	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(1), AKT1(1), AKT3(3), BTK(7), CDKN2A(26), GSK3A(3), IARS(3), INPP5D(8), PDK1(1), PIK3CA(29), PPP1R13B(5), PTEN(16), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), RPS6KB1(1), SFN(2), SHC1(2), SOS1(11), SOS2(7), TEC(4), YWHAB(1), YWHAQ(1)	9542176	142	93	125	21	52	32	5	20	33	0	0.00380	1.000	1.000
146	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(2), PSMC3(2), PSMD14(3), RPN1(1), UBE2A(2), UBE3A(6)	3424451	19	19	19	4	6	10	0	1	2	0	0.340	1.000	1.000
147	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO2(1), ENO3(1), FARS2(2), GOT2(3), PAH(3), TAT(1), YARS(1)	2200189	12	11	12	4	3	5	0	3	1	0	0.581	1.000	1.000
148	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(2), IFNG(1), IL10(2), IL12A(1), IL12B(3), IL16(5), IL1A(1), IL3(1), IL4(2), IL6(1), LTA(2), TNF(1)	2630179	23	21	23	6	7	8	1	6	1	0	0.409	1.000	1.000
149	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT1(2), ECHS1(1), EHHADH(1), GCDH(2), HADHA(2), SDHB(2), SDS(2)	2074543	12	11	12	9	3	2	2	2	3	0	0.988	1.000	1.000
150	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(2), JAK2(4), JAK3(7), MAPK1(1), MAPK3(1), STAT3(2), TYK2(8)	3098001	25	22	25	6	6	8	1	6	4	0	0.291	1.000	1.000
151	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(2), CSAD(2), GAD1(5), GAD2(6), GGT1(1)	1529828	16	13	16	9	7	6	0	2	1	0	0.895	1.000	1.000
152	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(5), HK1(2), HK2(5), HK3(5), IMPA1(2), PGM1(1), TGDS(1)	2708377	21	19	21	5	7	9	0	3	2	0	0.269	1.000	1.000
153	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), MIOX(1), UGDH(2)	2252196	12	12	12	4	5	6	0	0	1	0	0.528	1.000	1.000
154	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(8), CKM(2), FBL(2), GPT(1), LDHB(3), LDHC(3), MAPK14(1), NCL(1)	2350356	21	19	21	5	6	9	1	3	2	0	0.363	1.000	1.000
155	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(1), CAPN1(2), CAPNS2(1), CDK5(1), CDK5R1(1), CSNK1A1(2), CSNK1D(2), MAPT(4)	2464708	14	14	14	4	5	5	0	0	4	0	0.581	1.000	1.000
156	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(1), ST3GAL1(4), ST3GAL4(2), ST3GAL5(2), ST6GALNAC4(1), ST8SIA1(3)	1496006	13	12	13	6	5	5	1	1	1	0	0.728	1.000	1.000
157	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(1), AKR1D1(3), ARSB(2), ARSD(1), ARSE(2), CYP11B1(15), CYP11B2(7), HSD11B1(3), HSD11B2(1), HSD3B1(6), HSD3B2(3), SRD5A1(2), SRD5A2(2), STS(6), SULT1E1(1), SULT2A1(3), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(4), UGT1A9(3), UGT2B15(3), UGT2B4(8)	7240661	87	62	87	15	15	37	5	24	6	0	0.0101	1.000	1.000
158	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(1), EIF2B5(3), EIF2S2(1), IGF1(3), IGF1R(1), INPPL1(4), PDK2(2), PDPK1(1), PIK3CA(29), PIK3R1(2), PTEN(16), RPS6(1), RPS6KB1(1)	5228879	65	55	51	11	32	11	2	8	12	0	0.0645	1.000	1.000
159	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(5), ICAM1(2), ITGA4(4), ITGAL(1), ITGB1(5), ITGB2(5), SELE(4), SELL(2)	3220732	28	21	28	6	6	10	1	9	2	0	0.265	1.000	1.000
160	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	BPNT1(1), PAPSS2(1), SULT1A2(2), SULT1E1(1), SULT2A1(3)	1619951	8	8	8	4	2	3	0	2	1	0	0.882	1.000	1.000
161	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(1), CYP2A13(1), CYP2A6(5), CYP2A7(1), NAT2(2), XDH(11)	2120048	21	19	21	7	4	10	1	3	3	0	0.447	1.000	1.000
162	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(2), GHR(3), HRAS(5), INSR(10), IRS1(7), JAK2(4), MAP2K1(2), MAPK1(1), MAPK3(1), PIK3CA(29), PIK3R1(2), PLCG1(3), PRKCA(5), RAF1(1), RPS6KA1(2), SHC1(2), SLC2A4(2), SOS1(11), SRF(2), STAT5A(2)	8751025	96	73	82	16	36	32	6	15	7	0	0.00690	1.000	1.000
163	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(1), LDLR(4), MBTPS1(3), MBTPS2(3), SCAP(4), SREBF1(2), SREBF2(3)	3140491	20	19	20	5	9	5	1	4	1	0	0.328	1.000	1.000
164	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL13RA2(1), IL4R(2), JAK1(2), JAK2(4), TYK2(8)	2764965	19	18	19	6	6	5	3	1	4	0	0.626	1.000	1.000
165	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13RA1(2), IL13RA2(1), IL4R(2), JAK1(2), JAK2(4), TYK2(8)	2764965	19	18	19	6	6	5	3	1	4	0	0.626	1.000	1.000
166	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RANBP2(14), RANGAP1(4)	2241521	18	16	18	5	4	5	2	4	3	0	0.822	1.000	1.000
167	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(10), GNAS(6), GNB1(1), PRKAR1A(2)	1729256	19	18	19	8	6	5	2	5	1	0	0.855	1.000	1.000
168	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(1), CD4(1), FYN(5), HLA-DRA(1), HLA-DRB1(2), LCK(3), PTPRC(7), ZAP70(5)	2400965	25	20	25	7	8	5	3	7	2	0	0.557	1.000	1.000
169	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	NFKB1(2), PLCB1(8), PRKCA(5), RELA(3)	2182673	18	15	18	8	5	6	2	3	2	0	0.887	1.000	1.000
170	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	DAG1(2), ITPKA(1), ITPKB(6)	1596363	9	9	9	5	3	3	1	1	1	0	0.853	1.000	1.000
171	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(5), HK1(2), HK2(5), HK3(5), IMPA1(2), PGM1(1), TGDS(1)	3086344	21	19	21	5	7	9	0	3	2	0	0.249	1.000	1.000
172	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(8), G6PD(1), GCLC(2), GCLM(1), GGT1(1), GPX5(2), GSS(2), GSTA1(3), GSTA2(2), GSTA4(1), GSTM3(1), GSTM4(3), GSTM5(3), GSTP1(1), GSTZ1(2), IDH1(2), MGST1(2), PGD(1)	4764221	38	35	38	8	8	22	1	6	1	0	0.0906	1.000	1.000
173	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(2), GNAS(6), GNB1(1), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5)	2524765	25	24	25	9	9	7	1	5	3	0	0.829	1.000	1.000
174	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(10), AKT1(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CREB1(1), GNAS(6), HRAS(5), MAPK1(1), MAPK14(1), MAPK3(1), PIK3CA(29), PIK3R1(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), RAC1(1), RPS6KA1(2), RPS6KA5(4), SOS1(11)	7675854	95	74	81	16	38	24	6	21	6	0	0.0279	1.000	1.000
175	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(1), ACAA2(1), ACAT1(2), ECHS1(1), EHHADH(1), HADHA(2), HADHB(3), SDS(2)	2220067	13	13	13	7	3	4	1	3	2	0	0.933	1.000	1.000
176	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(1), ALPL(3), ALPP(3), ALPPL2(1), FPGS(2), GCH1(2), GGH(2)	1710521	14	12	14	9	5	6	0	2	1	0	0.906	1.000	1.000
177	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(5), ICAM1(2), ITGAL(1), ITGAM(7), ITGB2(5), SELE(4), SELL(2)	2773710	26	23	26	7	7	8	2	7	2	0	0.363	1.000	1.000
178	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(5), GBA(4), GBA3(11), LPO(2), MPO(4), PRDX6(2), TPO(10)	2222900	38	32	38	11	9	12	7	8	2	0	0.393	1.000	1.000
179	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(2), SEC61A2(1), SRP54(1), SRP72(2), SRPR(2)	1995421	8	8	8	3	2	3	2	1	0	0	0.810	1.000	1.000
180	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(4), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3)	3994474	25	23	25	8	6	5	2	5	7	0	0.615	1.000	1.000
181	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(4), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3)	3994474	25	23	25	8	6	5	2	5	7	0	0.615	1.000	1.000
182	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP6V0A1(4), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3)	3994474	25	23	25	8	6	5	2	5	7	0	0.615	1.000	1.000
183	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(1), CSF1(2), HLA-DRA(1), HLA-DRB1(2), IFNA1(1), IFNB1(2), IFNG(1), IL10(2), IL12A(1), IL12B(3), IL1A(1), IL3(1), IL4(2), IL6(1), IL7(1), LTA(2), TGFB1(1), TGFB2(3), TNF(1)	3532592	29	26	29	8	9	9	1	6	4	0	0.363	1.000	1.000
184	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CCNB1(2), CDC25B(2), CDC25C(1), PRKCA(5)	2442594	10	10	10	4	3	2	2	1	2	0	0.829	1.000	1.000
185	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	UBE2A(2), UBE2C(1), UBE2D1(1), UBE2D2(2), UBE2E3(2), UBE2G1(1), UBE2G2(1), UBE2J1(2), UBE2L6(1), UBE2M(1), UBE3A(6)	2775361	20	19	20	6	5	9	0	3	3	0	0.639	1.000	1.000
186	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(2), GCK(5), GFPT1(1), GNE(2), GNPDA2(4), HEXA(5), HK1(2), HK2(5), HK3(5), RENBP(2), UAP1(2)	4479741	35	28	35	8	9	15	0	5	6	0	0.228	1.000	1.000
187	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(2), GABARAP(1), GABRA1(7), GABRA2(13), GABRA3(4), GABRA4(5), GABRA5(6), GABRA6(8), GPHN(2), NSF(2), UBQLN1(2)	3164391	52	42	52	12	9	18	6	12	7	0	0.296	1.000	1.000
188	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(3), ARPC1A(4), CDC42(1), RAC1(1), WASF1(1), WASL(2)	2152294	12	12	11	9	5	5	0	1	1	0	0.992	1.000	1.000
189	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(5), FOS(2), HRAS(5), IL3(1), JAK2(4), MAP2K1(2), MAPK3(1), RAF1(1), SHC1(2), SOS1(11), STAT5A(2)	4680668	36	33	35	8	7	15	3	7	4	0	0.228	1.000	1.000
190	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(6), EGFR(7), ERBB3(4), NRG1(3), UBE2D1(1)	2703897	21	19	20	6	5	7	0	6	3	0	0.538	1.000	1.000
191	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(2), CPT1A(5), LEPR(15), PRKAA2(5), PRKAB2(1), PRKAG2(4)	3837576	32	28	32	7	6	10	4	7	5	0	0.346	1.000	1.000
192	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP6V0A1(4), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), FDXR(3)	4248967	28	25	28	8	7	7	2	5	7	0	0.473	1.000	1.000
193	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(1), GUSB(2), UCHL3(1), UGDH(2), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(4), UGT1A9(3), UGT2B15(3), UGT2B4(8)	4657758	35	30	35	8	4	15	4	11	1	0	0.309	1.000	1.000
194	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD3D(1), IFNG(1), IL4(2), TGFB1(1), TGFB2(3), TGFBR2(3), TGFBR3(8)	2812125	19	17	19	9	7	5	0	4	3	0	0.875	1.000	1.000
195	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(1), ADSS(1), HPRT1(1), IMPDH1(2), MTHFD2(4), POLB(1), POLD1(2), POLG(2), PRPS2(1), RRM1(1)	3304059	16	14	16	4	4	5	0	6	1	0	0.426	1.000	1.000
196	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNB1(2), CDC25B(2), CDC25C(1), CDK7(1), SHH(2), XPO1(2)	2295546	10	10	10	4	2	2	1	4	1	0	0.861	1.000	1.000
197	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(2), FARSA(5), GOT2(3), PAH(3), TAT(1), YARS(1), YARS2(2)	2309679	17	15	17	6	4	9	0	3	1	0	0.616	1.000	1.000
198	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(2), HLA-A(7), ITGB1(5), KLRC1(1), KLRC3(2), KLRD1(1), MAP2K1(2), MAPK3(1), PAK1(2), PIK3CA(29), PIK3R1(2), RAC1(1), SYK(1), VAV1(7)	4925605	63	51	50	12	32	12	1	12	5	1	0.0861	1.000	1.000
199	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(3), EPOR(2), FOS(2), HRAS(5), JAK2(4), JUN(3), MAP2K1(2), MAPK3(1), MAPK8(3), PLCG1(3), RAF1(1), SHC1(2), SOS1(11), STAT5A(2)	5686152	44	36	42	9	14	15	3	8	4	0	0.150	1.000	1.000
200	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(2), IFNB1(2), JAK1(2), STAT1(2), STAT2(1), TYK2(8)	2863741	18	18	18	6	6	7	1	1	3	0	0.608	1.000	1.000
201	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(2), PSMB8(2)	2307764	7	7	7	3	4	2	0	0	1	0	0.802	1.000	1.000
202	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(3), F13A1(6), F2R(2), FGA(5), FGB(4), FGG(2), PLAT(1), PLAU(2), PLG(2), SERPINB2(4)	3549422	31	25	31	8	6	11	4	6	3	1	0.471	1.000	1.000
203	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(13), CD38(2), ENPP1(8), ENPP3(6), NADSYN1(7), NMNAT2(2), NNT(10), NT5E(2)	3850423	50	39	50	11	13	19	2	10	6	0	0.185	1.000	1.000
204	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BRAF(8), CREB1(1), CREB3(2), CREB5(3), MAPK1(1), RAF1(1), SNX13(5)	2985230	21	19	21	7	8	6	1	3	3	0	0.719	1.000	1.000
205	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(10), AKT1(1), BAX(1), BCL2L1(1), CSF2RB(5), IGF1(3), IGF1R(1), IL3(1), KIT(7), PIK3CA(29), PIK3R1(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3)	5809382	72	58	59	15	34	18	2	15	3	0	0.0590	1.000	1.000
206	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	64	ATM(8), CCNA1(1), CCNB1(2), CCND1(1), CCND2(3), CCND3(1), CCNE1(3), CCNE2(2), CDK7(1), CDKN1A(2), CDKN2A(26), CDKN2B(1), CDKN2C(1), CREB3(2), CREB3L3(1), CREB3L4(2), E2F1(2), E2F5(2), GADD45A(1), MCM2(1), MCM3(1), MCM4(5), MCM5(6), MCM6(3), MCM7(3), MDM2(2), MYC(1), MYT1(4), ORC1L(3), ORC2L(1), ORC3L(2), ORC5L(3), POLE(7), POLE2(2), PRIM1(3), RB1(12), RBL1(5), RPA1(1), RPA2(1), TFDP1(3), TFDP2(3), TNXB(19), TP53(147), WEE1(4)	20348018	304	159	252	39	53	91	24	54	82	0	2.65e-07	1.000	1.000
207	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	10	CASP7(2), DFFB(2), GZMB(1), HMGB2(1), TOP2A(2), TOP2B(4)	2467278	12	11	12	6	3	4	2	2	1	0	0.954	1.000	1.000
208	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(1), CBS(4), GGT1(1), MARS(1), MAT1A(1), PAPSS2(1), SCLY(1), SEPHS1(3)	3276787	13	11	13	7	4	5	0	0	4	0	0.873	1.000	1.000
209	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(1), EIF4A1(5), EIF4A2(2), EIF4B(5), EIF4G1(10), EIF4G2(3), EIF4G3(4), PDK2(2), PDPK1(1), PIK3CA(29), PIK3R1(2), PTEN(16), RPS6(1), RPS6KB1(1), TSC1(5), TSC2(5)	7345129	92	68	78	16	43	18	4	12	15	0	0.0568	1.000	1.000
210	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(1), IARS(3), LARS(1), LARS2(3), PDHA1(3), PDHA2(8)	2655435	19	17	19	7	4	7	2	5	1	0	0.810	1.000	1.000
211	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(3), FH(2), MDH1(1), OGDH(3), SDHA(3), SUCLA2(2)	2485493	14	14	14	7	3	6	1	3	1	0	0.879	1.000	1.000
212	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), ECHS1(1), EHHADH(1), HADHA(2), SDS(2)	3220279	18	16	18	8	4	9	1	1	3	0	0.782	1.000	1.000
213	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	BPNT1(1), CHST11(2), CHST12(1), PAPSS2(1), SULT1A1(2), SULT1A2(2), SULT1E1(1), SULT2A1(3)	2459677	13	13	13	6	2	5	0	5	1	0	0.827	1.000	1.000
214	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(8), EIF2AK4(7), EIF2B5(3), EIF2S2(1), EIF5(3), PPP1CA(1)	3074286	23	22	23	7	9	9	0	3	2	0	0.638	1.000	1.000
215	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	19	APAF1(4), BAK1(1), BAX(1), BCL2L1(1), BIRC2(1), BIRC3(3), CASP7(2), CASP8(2), CASP9(3), DFFB(2)	3602132	20	17	19	7	6	4	1	5	4	0	0.820	1.000	1.000
216	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(3), EGF(6), EGFR(7), FOS(2), HRAS(5), JAK1(2), JUN(3), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK3(1), MAPK8(3), PIK3CA(29), PIK3R1(2), PLCG1(3), PRKCA(5), RAF1(1), RASA1(8), SHC1(2), SOS1(11), SRF(2), STAT1(2), STAT3(2), STAT5A(2)	9917603	107	78	91	16	45	28	4	17	13	0	0.00570	1.000	1.000
217	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	CREBBP(17), EP300(9), FYN(5), IL2RG(1), IL7(1), IL7R(8), JAK1(2), JAK3(7), LCK(3), NMI(2), PIK3CA(29), PIK3R1(2), STAT5A(2)	7405427	88	63	73	17	31	21	4	24	8	0	0.0489	1.000	1.000
218	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(1), CDKN1A(2), EPOR(2), GRIN1(1), HIF1A(1), JAK2(4), NFKB1(2), RELA(3), SOD2(1)	3335902	17	13	17	6	2	6	2	4	3	0	0.678	1.000	1.000
219	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM2(1), CAMK1G(3), CAMK2A(1), CAMK2B(2), CAMK2D(1), CAMK4(3), CAMKK2(1), CREB1(1), SYT1(4)	3046636	17	16	17	9	3	6	4	2	2	0	0.951	1.000	1.000
220	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(1), IL2RG(1), IL4(2), IL4R(2), IRS1(7), JAK1(2), JAK3(7), RPS6KB1(1), SHC1(2), STAT6(2)	3929436	27	22	27	9	5	12	1	5	4	0	0.546	1.000	1.000
221	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(3), FOS(2), HRAS(5), JAK1(2), JUN(3), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK3(1), MAPK8(3), PDGFRA(10), PIK3CA(29), PIK3R1(2), PLCG1(3), PRKCA(5), RAF1(1), RASA1(8), SHC1(2), SOS1(11), SRF(2), STAT1(2), STAT3(2), STAT5A(2)	9234474	104	75	89	18	45	28	5	15	11	0	0.0200	1.000	1.000
222	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(1), ACOX1(2), ACOX3(5), ELOVL5(2), ELOVL6(1), FADS1(1), FADS2(1), FASN(2), HADHA(2), HSD17B12(2), PECR(1), SCD(2)	3804969	22	18	22	9	5	8	3	2	4	0	0.632	1.000	1.000
223	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), IL10(2), IL10RA(2), IL1A(1), IL6(1), JAK1(2), STAT1(2), STAT3(2), STAT5A(2), TNF(1)	3239749	17	16	17	8	6	6	1	2	2	0	0.800	1.000	1.000
224	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(8), G6PD(1), GCLC(2), GCLM(1), GGT1(1), GPX5(2), GPX6(2), GSR(4), GSS(2), GSTA1(3), GSTA2(2), GSTA4(1), GSTA5(2), GSTM3(1), GSTM4(3), GSTM5(3), GSTP1(1), GSTZ1(2), IDH1(2), MGST1(2), OPLAH(5)	5769397	50	46	50	10	11	27	0	10	2	0	0.0454	1.000	1.000
225	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(2), IKBKAP(4), IKBKB(2), MAP3K1(3), MAP3K14(1), NFKB1(2), RELA(3), TNFAIP3(5), TRAF3(3), TRAF6(5)	4813758	30	26	30	9	5	10	1	8	6	0	0.629	1.000	1.000
226	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(1), BCL2L1(1), CASP9(3), CDC42(1), CHUK(2), H2AFX(1), HRAS(5), MAP2K1(2), MAPK3(1), NFKB1(2), PIK3CA(29), PIK3R1(2), RAC1(1), RAF1(1), RALA(3), RALBP1(1), RALGDS(1), RELA(3)	5066031	60	48	45	12	31	12	2	12	3	0	0.114	1.000	1.000
227	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLB(1), POLD1(2), POLD2(1), POLE(7), POLG(2), POLL(2), POLQ(19)	4432425	34	27	34	8	11	13	1	7	2	0	0.236	1.000	1.000
228	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(4), BAK1(1), BAX(1), BCL2L1(1), CASP8AP2(6), CASP9(3), CES1(2)	2975887	18	14	17	6	6	3	2	6	1	0	0.822	1.000	1.000
229	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(2), ACADM(1), ACADS(2), ACADVL(1), ACSL1(2), ACSL3(2), ACSL4(2), CPT1A(5), CPT2(2), DCI(1), EHHADH(1), HADHA(2), PECR(1), SCP2(1), SLC25A20(1)	4455792	26	26	26	7	4	7	2	8	5	0	0.494	1.000	1.000
230	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(3), FOS(2), HRAS(5), IL6(1), IL6R(1), IL6ST(1), JAK1(2), JAK2(4), JAK3(7), JUN(3), MAP2K1(2), MAPK3(1), PTPN11(3), RAF1(1), SHC1(2), SOS1(11), SRF(2), STAT3(2)	6320392	53	44	51	10	16	17	3	11	6	0	0.0955	1.000	1.000
231	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(3), FDFT1(1), FDPS(1), HMGCR(1), IDI1(1), LSS(2), MVD(1), PMVK(1), SC5DL(1), SQLE(3)	2935905	15	14	15	5	2	7	0	6	0	0	0.639	1.000	1.000
232	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(2), ATG7(6), BECN1(2), GABARAP(1), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), IFNG(1), PIK3C3(5), PIK3R4(7), PRKAA2(5), ULK1(4), ULK2(5)	5589918	53	44	52	10	21	12	4	8	8	0	0.148	1.000	1.000
233	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2)	3514241	19	19	19	7	5	12	0	1	1	0	0.650	1.000	1.000
234	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(1), CREB1(1), HRAS(5), MAPK1(1), MAPK3(1), MAPK7(1), MEF2A(3), MEF2C(4), MEF2D(3), NTRK1(4), PIK3CA(29), PIK3R1(2), PLCG1(3), RPS6KA1(2), SHC1(2)	5026194	62	50	48	14	30	19	2	8	3	0	0.118	1.000	1.000
235	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(1), ATF2(3), CDC42(1), DLD(2), DUSP10(5), DUSP4(2), DUSP8(1), GAB1(3), GADD45A(1), GCK(5), IL1R1(1), JUN(3), MAP2K4(1), MAP2K5(1), MAP2K7(1), MAP3K1(3), MAP3K11(2), MAP3K12(4), MAP3K13(5), MAP3K3(1), MAP3K4(4), MAP3K5(4), MAP3K7(2), MAP3K9(4), MAPK10(1), MAPK7(1), MAPK8(3), MAPK9(1), MYEF2(4), NFATC3(6), NR2C2(3), PAPPA(8), SHC1(2), TP53(147), TRAF6(5)	13319207	241	153	191	37	47	79	20	44	51	0	0.000262	1.000	1.000
236	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(10), ARHGEF1(2), F2R(2), F2RL3(1), GNA12(2), GNA13(1), GNAI1(3), GNB1(1), MAP3K7(2), PIK3CA(29), PIK3R1(2), PLCB1(8), PPP1R12B(5), PRKCA(5), ROCK1(5)	6834498	78	60	65	16	36	20	4	15	3	0	0.0939	1.000	1.000
237	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(5), ICAM1(2), ITGA4(4), ITGAL(1), ITGAM(7), ITGB1(5), ITGB2(5), SELE(4), SELL(2), SELP(11)	4238792	46	32	46	11	11	17	2	11	5	0	0.249	1.000	1.000
238	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(11), AP2A1(2), AP2M1(1), CALM2(1), DNM1(2), EPN1(3), EPS15(5), PICALM(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), SYNJ1(4), SYNJ2(4), SYT1(4)	5731532	51	45	50	10	17	15	4	6	9	0	0.167	1.000	1.000
239	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACO1(2), ACO2(3), ACSS1(3), FH(2), IDH1(2), MDH1(1), MDH2(1), SUCLA2(2)	3521600	16	16	16	7	5	7	1	2	1	0	0.799	1.000	1.000
240	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(3), ARG1(2), ASL(4), CKM(2), CKMT2(3), CPS1(30), DAO(2), EPRS(12), GATM(1), GLUD1(4), GLUD2(9), GOT2(3), LAP3(1), NOS1(11), NOS3(2), OAT(1), OTC(3), P4HA1(2), P4HA2(3), P4HA3(3), PARS2(4), PRODH(1), PYCR1(1), RARS(4), RARS2(2)	9507485	113	75	112	23	27	47	4	18	17	0	0.0223	1.000	1.000
241	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(1), AKR1D1(3), ARSD(1), ARSE(2), CARM1(1), CYP11B1(15), CYP11B2(7), CYP19A1(4), HSD11B1(3), HSD11B2(1), HSD17B1(1), HSD17B12(2), HSD17B7(1), HSD3B1(6), HSD3B2(3), LCMT1(2), LCMT2(1), METTL2B(1), METTL6(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), SRD5A1(2), SRD5A2(2), STS(6), SULT1E1(1), SULT2A1(3), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(4), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(4), UGT2B11(5), UGT2B15(3), UGT2B28(5), UGT2B4(8), UGT2B7(2), WBSCR22(3)	13038741	146	85	146	25	31	55	11	34	15	0	0.00146	1.000	1.000
242	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(1), EIF4A1(5), EIF4A2(2), EIF4G1(10), EIF4G2(3), EIF4G3(4), GHR(3), IRS1(7), MAPK1(1), MAPK14(1), MAPK3(1), PABPC1(4), PDK2(2), PDPK1(1), PIK3CA(29), PIK3R1(2), PRKCA(5), PTEN(16), RPS6KB1(1)	7463396	98	71	84	18	43	22	6	15	12	0	0.0874	1.000	1.000
243	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA4(1), PSMA5(1), PSMB3(1), PSMB4(2), PSMC2(4), PSMC3(2), PSMD1(4), PSMD11(1), PSMD12(1), PSMD13(1), PSMD2(1)	4216158	19	16	19	9	4	10	1	3	1	0	0.901	1.000	1.000
244	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM2(1), CD3D(1), FOS(2), FYN(5), HRAS(5), JUN(3), LCK(3), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK3(1), MAPK8(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NFKB1(2), PIK3CA(29), PIK3R1(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(5), PTPN7(1), RAC1(1), RAF1(1), RASA1(8), RELA(3), SHC1(2), SOS1(11), SYT1(4), VAV1(7), ZAP70(5)	12625808	139	86	124	25	54	40	9	22	14	0	0.0111	1.000	1.000
245	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(1), AKT3(3), IARS(3), IL13RA1(2), IL2RG(1), IL4(2), IL4R(2), INPP5D(8), JAK1(2), JAK2(4), JAK3(7), NR0B2(1), PI3(1), PIK3CA(29), PPP1R13B(5), RPS6KB1(1), SERPINA4(7), SHC1(2), SOS1(11), SOS2(7), STAT6(2), TYK2(8)	9782296	109	76	96	22	42	29	4	21	13	0	0.0403	1.000	1.000
246	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARF1(1), ARFGAP1(1), ARFGEF2(4), CLTA(1), COPA(8), GBF1(6), GPLD1(1), KDELR2(1)	4288103	23	20	23	9	10	6	0	6	1	0	0.772	1.000	1.000
247	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(3), ACVR1C(4), AKT1(1), AKT3(3), ARRB1(2), ATF2(3), ATF4(2), BDNF(1), BRAF(8), CACNA1A(11), CACNA1B(10), CACNA1C(18), CACNA1D(6), CACNA1E(19), CACNA1F(10), CACNA1G(7), CACNA1H(5), CACNA1I(12), CACNA1S(7), CACNA2D1(10), CACNA2D2(3), CACNA2D3(3), CACNA2D4(8), CACNB1(1), CACNB2(5), CACNB3(2), CACNB4(1), CACNG2(1), CACNG3(4), CACNG4(1), CACNG6(1), CACNG7(4), CACNG8(2), CD14(2), CDC25B(2), CDC42(1), CHP(2), CHUK(2), CRKL(1), DAXX(3), DUSP10(5), DUSP16(2), DUSP4(2), DUSP5(5), DUSP6(2), DUSP7(1), DUSP8(1), DUSP9(2), EGF(6), EGFR(7), ELK4(1), FAS(1), FASLG(1), FGF10(2), FGF12(3), FGF14(2), FGF18(1), FGF19(1), FGF2(2), FGF22(1), FGF23(2), FGF3(1), FGF5(3), FGF6(2), FGF8(1), FGFR1(1), FGFR2(4), FGFR3(4), FGFR4(2), FLNA(14), FLNB(3), FLNC(16), FOS(2), GADD45A(1), GADD45B(1), GADD45G(1), GNA12(2), GNG12(1), HRAS(5), IKBKB(2), IL1A(1), IL1B(1), IL1R1(1), IL1R2(3), JUN(3), JUND(2), KRAS(2), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP2K5(1), MAP2K6(2), MAP2K7(1), MAP3K1(3), MAP3K12(4), MAP3K13(5), MAP3K14(1), MAP3K3(1), MAP3K4(4), MAP3K5(4), MAP3K6(1), MAP3K7(2), MAP4K1(3), MAP4K2(1), MAP4K3(7), MAP4K4(6), MAPK1(1), MAPK10(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8(3), MAPK8IP1(2), MAPK8IP3(4), MAPK9(1), MAPKAPK2(2), MAPKAPK3(1), MAPKAPK5(3), MAPT(4), MEF2C(4), MKNK2(1), MOS(4), MRAS(2), MYC(1), NF1(22), NFATC2(4), NFATC4(2), NFKB1(2), NFKB2(2), NLK(2), NR4A1(4), NRAS(1), NTF3(3), NTRK1(4), NTRK2(1), PAK1(2), PAK2(1), PDGFB(1), PDGFRA(10), PDGFRB(6), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PPM1A(2), PPM1B(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), PTPN5(1), PTPN7(1), PTPRR(9), RAC1(1), RAF1(1), RAP1A(1), RAP1B(1), RAPGEF2(8), RASA1(8), RASA2(3), RASGRF1(7), RASGRF2(7), RASGRP1(1), RASGRP2(1), RASGRP3(8), RASGRP4(5), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), RPS6KA4(2), RPS6KA5(4), RPS6KA6(5), RRAS2(2), SOS1(11), SOS2(7), SRF(2), STK3(2), STK4(2), TAOK1(7), TAOK2(5), TAOK3(4), TGFB1(1), TGFB2(3), TGFBR2(3), TNF(1), TNFRSF1A(2), TP53(147), TRAF6(5)	75847612	830	174	773	229	195	298	57	141	139	0	0.0127	1.000	1.000
248	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(1), ACTG1(2), ACTN1(2), ACTN2(10), ACTN3(2), ACTN4(5), AKT1(1), AKT3(3), ARHGAP5(2), BCAR1(6), BIRC2(1), BIRC3(3), BRAF(8), CAPN2(2), CAV2(1), CAV3(1), CCND1(1), CCND2(3), CCND3(1), CDC42(1), COL11A1(46), COL11A2(13), COL1A1(11), COL1A2(15), COL2A1(12), COL3A1(16), COL4A1(11), COL4A2(14), COL4A4(11), COL4A6(10), COL5A1(8), COL5A2(14), COL5A3(13), COL6A1(1), COL6A2(7), COL6A3(13), COL6A6(21), COMP(2), CRKL(1), CTNNB1(4), DIAPH1(1), DOCK1(4), EGF(6), EGFR(7), ERBB2(2), FARP2(7), FIGF(2), FLNA(14), FLNB(3), FLNC(16), FLT1(11), FN1(21), FYN(5), GRLF1(13), HGF(10), HRAS(5), IBSP(6), IGF1(3), IGF1R(1), ILK(2), ITGA1(4), ITGA10(8), ITGA11(6), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGA7(4), ITGA8(14), ITGA9(2), ITGAV(4), ITGB1(5), ITGB3(4), ITGB4(8), ITGB6(1), ITGB7(1), ITGB8(5), JUN(3), KDR(16), LAMA1(17), LAMA2(23), LAMA3(11), LAMA4(17), LAMA5(7), LAMB1(6), LAMB2(3), LAMB3(3), LAMB4(6), LAMC1(7), LAMC2(5), LAMC3(5), MAP2K1(2), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(3), MAPK9(1), MET(4), MYL2(2), MYL9(1), MYLK(8), MYLK2(4), MYLPF(1), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(6), PARVB(1), PARVG(2), PDGFB(1), PDGFC(2), PDGFD(1), PDGFRA(10), PDGFRB(6), PDPK1(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PIP5K1C(2), PPP1CA(1), PRKCA(5), PRKCG(9), PTEN(16), PTK2(6), PXN(3), RAC1(1), RAF1(1), RAP1A(1), RAP1B(1), RAPGEF1(4), RELN(34), ROCK1(5), ROCK2(3), SHC1(2), SHC2(5), SHC3(2), SHC4(5), SOS1(11), SOS2(7), SPP1(1), THBS1(1), THBS2(16), THBS3(3), THBS4(1), TLN1(6), TLN2(14), TNC(14), TNN(21), TNR(26), TNXB(19), VASP(2), VAV1(7), VAV2(4), VAV3(1), VCL(2), VEGFC(6), VWF(17), ZYX(1)	98378517	1071	173	1052	313	301	414	67	164	125	0	0.143	1.000	1.000
249	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	235	ADCYAP1R1(9), ADORA1(3), ADORA2A(5), ADORA3(1), ADRA1A(2), ADRA1B(3), ADRA2B(6), ADRA2C(2), ADRB1(1), ADRB2(4), AGTR1(5), AGTR2(3), AVPR1A(3), AVPR1B(2), AVPR2(3), BDKRB1(3), BDKRB2(3), C3AR1(2), C5AR1(4), CALCR(10), CALCRL(4), CCKAR(2), CCKBR(2), CGA(2), CHRM2(9), CHRM3(5), CHRM4(1), CHRM5(3), CNR1(5), CNR2(2), CRHR1(4), CRHR2(3), CTSG(3), CYSLTR1(2), CYSLTR2(1), DRD1(1), DRD2(4), DRD3(5), DRD4(1), DRD5(5), EDNRA(1), EDNRB(5), F2R(2), F2RL1(3), F2RL2(1), F2RL3(1), FPR1(1), FSHB(2), FSHR(15), GABBR1(5), GABBR2(3), GABRA1(7), GABRA2(13), GABRA3(4), GABRA4(5), GABRA5(6), GABRA6(8), GABRB1(4), GABRB2(6), GABRB3(11), GABRD(2), GABRE(4), GABRG1(15), GABRG2(4), GABRG3(10), GABRP(3), GABRQ(7), GABRR1(4), GABRR2(4), GALR1(5), GH1(2), GH2(5), GHR(3), GHRHR(4), GHSR(4), GLP1R(1), GLP2R(5), GLRA1(2), GLRA2(5), GLRA3(3), GLRB(3), GPR156(4), GPR35(1), GPR50(5), GPR63(4), GPR83(2), GRIA1(9), GRIA2(7), GRIA3(11), GRIA4(10), GRID1(15), GRID2(15), GRIK1(5), GRIK2(9), GRIK3(10), GRIK4(4), GRIK5(2), GRIN1(1), GRIN2A(16), GRIN2B(18), GRIN2C(3), GRIN2D(4), GRIN3A(10), GRIN3B(4), GRM1(13), GRM2(3), GRM3(14), GRM4(3), GRM5(12), GRM6(6), GRM7(10), GRM8(14), GRPR(3), GZMA(4), HCRTR2(3), HRH1(3), HRH2(2), HRH3(1), HRH4(4), HTR1A(8), HTR1B(3), HTR1E(5), HTR1F(3), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(3), HTR5A(4), HTR6(2), HTR7(4), LEPR(15), LHB(1), LHCGR(9), LTB4R2(1), MAS1(3), MC2R(2), MC3R(2), MC4R(2), MC5R(3), MCHR1(2), MCHR2(6), MLNR(2), MTNR1A(1), MTNR1B(10), NMBR(3), NMUR2(2), NPBWR1(4), NPBWR2(3), NPFFR2(8), NPY1R(3), NPY2R(4), NPY5R(4), NR3C1(1), NTSR1(4), NTSR2(4), OPRD1(2), OPRK1(1), OPRL1(2), OPRM1(6), OXTR(1), P2RX2(4), P2RX3(5), P2RX4(1), P2RX5(1), P2RX7(2), P2RY1(3), P2RY10(5), P2RY13(1), P2RY14(3), P2RY2(3), P2RY4(3), P2RY6(2), P2RY8(2), PARD3(8), PPYR1(4), PRL(1), PRLHR(2), PRLR(6), PRSS1(4), PRSS3(2), PTAFR(3), PTGDR(6), PTGER2(2), PTGER3(5), PTGER4(2), PTGFR(5), PTGIR(1), PTH2R(6), RXFP1(8), RXFP2(3), SCTR(1), SSTR1(3), SSTR2(2), SSTR3(2), SSTR4(2), SSTR5(1), TAAR1(5), TAAR2(4), TAAR5(5), TAAR6(5), TAAR8(3), TAAR9(3), TACR1(3), TACR2(1), TACR3(4), TBXA2R(2), THRA(1), THRB(2), TRHR(2), TRPV1(3), TSHR(5), VIPR2(3)	58501687	917	170	914	312	200	387	79	155	96	0	0.0567	1.000	1.000
250	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(9), APC2(2), AXIN2(2), BTRC(1), CACYBP(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CCND1(1), CCND2(3), CCND3(1), CER1(2), CHD8(9), CHP(2), CREBBP(17), CSNK1A1(2), CSNK1A1L(5), CSNK2A1(3), CTBP1(2), CTNNB1(4), CUL1(4), CXXC4(1), DAAM1(1), DAAM2(7), DKK1(4), DKK2(1), DKK4(1), DVL1(3), DVL3(2), EP300(9), FBXW11(1), FOSL1(1), FZD1(1), FZD10(2), FZD2(1), FZD3(5), FZD4(1), FZD6(3), FZD7(3), FZD8(1), FZD9(2), JUN(3), LEF1(3), LRP5(6), LRP6(6), MAP3K7(2), MAPK10(1), MAPK8(3), MAPK9(1), MYC(1), NFAT5(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NKD1(2), NKD2(2), NLK(2), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PORCN(2), PPARD(2), PPP2R1A(8), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRICKLE1(7), PRICKLE2(3), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), PSEN1(3), RAC1(1), RBX1(1), ROCK1(5), ROCK2(3), RUVBL1(4), SENP2(3), SFRP1(1), SFRP4(4), SFRP5(1), SIAH1(1), SKP1(1), SMAD2(2), SMAD3(1), SMAD4(5), TBL1XR1(2), TBL1Y(2), TCF7(1), TCF7L2(1), TP53(147), VANGL1(1), VANGL2(2), WIF1(6), WNT1(1), WNT10A(1), WNT10B(4), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT3A(2), WNT5A(1), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT9A(1), WNT9B(1)	42805750	487	170	436	130	96	185	42	77	87	0	0.0782	1.000	1.000
251	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY7(7), ADCY8(18), ADCY9(3), ADORA2A(5), ADRA1A(2), ADRA1B(3), ADRA1D(3), ADRB1(1), ADRB2(4), AGTR1(5), ATP2A1(1), ATP2A2(3), ATP2A3(3), ATP2B1(4), ATP2B2(7), ATP2B3(3), ATP2B4(3), AVPR1A(3), AVPR1B(2), BDKRB1(3), BDKRB2(3), BST1(1), CACNA1A(11), CACNA1B(10), CACNA1C(18), CACNA1D(6), CACNA1E(19), CACNA1F(10), CACNA1G(7), CACNA1H(5), CACNA1I(12), CACNA1S(7), CALM2(1), CALML6(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CAMK4(3), CCKAR(2), CCKBR(2), CD38(2), CHP(2), CHRM2(9), CHRM3(5), CHRM5(3), CHRNA7(1), CYSLTR1(2), CYSLTR2(1), DRD1(1), EDNRA(1), EDNRB(5), EGFR(7), ERBB2(2), ERBB3(4), ERBB4(13), F2R(2), GNA11(1), GNA14(3), GNA15(1), GNAL(1), GNAS(6), GRIN1(1), GRIN2A(16), GRIN2C(3), GRIN2D(4), GRM1(13), GRM5(12), GRPR(3), HRH1(3), HRH2(2), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(3), HTR5A(4), HTR6(2), HTR7(4), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(14), ITPR3(4), LHCGR(9), LTB4R2(1), MYLK(8), MYLK2(4), NOS1(11), NOS3(2), NTSR1(4), OXTR(1), P2RX2(4), P2RX3(5), P2RX4(1), P2RX5(1), P2RX7(2), PDE1A(2), PDE1B(3), PDE1C(13), PDGFRA(10), PDGFRB(6), PHKA1(6), PHKA2(4), PHKB(6), PHKG1(2), PHKG2(1), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLCD1(1), PLCD3(1), PLCE1(14), PLCG1(3), PLCG2(5), PLCZ1(5), PLN(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), PTAFR(3), PTGER3(5), PTGFR(5), RYR1(28), RYR2(120), RYR3(52), SLC25A5(1), SLC25A6(1), SLC8A1(15), SLC8A2(3), SLC8A3(3), SPHK2(1), TACR1(3), TACR2(1), TACR3(4), TBXA2R(2), TNNC1(1), TRHR(2), TRPC1(6), VDAC1(1)	71573339	877	169	872	272	196	381	56	150	92	2	0.0135	1.000	1.000
252	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(1), ACTG1(2), COL11A1(46), COL11A2(13), COL17A1(4), COL1A1(11), COL1A2(15), COL2A1(12), COL3A1(16), COL4A1(11), COL4A2(14), COL4A4(11), COL4A6(10), COL5A1(8), COL5A2(14), COL5A3(13), COL6A1(1), COL6A2(7), COL6A3(13), COL6A6(21), COMP(2), DES(3), DSC1(8), DSC2(1), DSC3(6), DSG1(9), DSG2(3), DSG3(4), DSG4(8), FN1(21), GJA1(4), GJA10(7), GJA4(1), GJA5(1), GJA8(4), GJA9(4), GJB2(1), GJB4(3), GJC1(3), GJC2(1), GJC3(1), GJD2(2), GJD4(2), IBSP(6), INA(2), ITGA6(7), ITGB4(8), KRT1(1), KRT10(1), KRT12(3), KRT13(4), KRT14(3), KRT15(1), KRT16(3), KRT17(2), KRT18(2), KRT2(5), KRT20(2), KRT23(4), KRT24(3), KRT27(2), KRT28(2), KRT3(2), KRT31(2), KRT32(2), KRT33A(1), KRT35(1), KRT36(2), KRT37(2), KRT39(1), KRT4(2), KRT40(2), KRT5(1), KRT6A(2), KRT6B(3), KRT6C(1), KRT71(3), KRT72(4), KRT73(6), KRT74(2), KRT75(1), KRT76(3), KRT77(5), KRT79(2), KRT8(1), KRT81(3), KRT82(2), KRT83(2), KRT84(4), KRT85(2), KRT86(1), KRT9(2), LAMA1(17), LAMA2(23), LAMA3(11), LAMA4(17), LAMA5(7), LAMB1(6), LAMB2(3), LAMB3(3), LAMB4(6), LAMC1(7), LAMC2(5), LAMC3(5), LMNA(1), NES(13), PRPH(3), RELN(34), SPP1(1), THBS1(1), THBS2(16), THBS3(3), THBS4(1), TNC(14), TNN(21), TNR(26), TNXB(19), VIM(7), VWF(17)	65915247	757	168	755	231	206	303	57	108	83	0	0.265	1.000	1.000
253	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	109	ABL1(3), ANAPC1(6), ANAPC4(3), ANAPC5(5), ATM(8), ATR(13), BUB1(4), BUB1B(6), BUB3(2), CCNA1(1), CCNA2(1), CCNB1(2), CCNB2(1), CCNB3(11), CCND1(1), CCND2(3), CCND3(1), CCNE1(3), CCNE2(2), CDC14A(1), CDC14B(2), CDC16(1), CDC20(1), CDC23(1), CDC25B(2), CDC25C(1), CDC27(3), CDC6(6), CDC7(3), CDK7(1), CDKN1A(2), CDKN2A(26), CDKN2B(1), CDKN2C(1), CHEK1(5), CHEK2(3), CREBBP(17), CUL1(4), DBF4(4), E2F1(2), EP300(9), ESPL1(4), GADD45A(1), GADD45B(1), GADD45G(1), HDAC1(2), MAD1L1(7), MAD2L1(2), MCM2(1), MCM3(1), MCM4(5), MCM5(6), MCM6(3), MCM7(3), MDM2(2), ORC1L(3), ORC2L(1), ORC3L(2), ORC5L(3), PKMYT1(1), PLK1(2), PRKDC(12), PTTG1(2), PTTG2(2), RB1(12), RBL1(5), RBL2(8), RBX1(1), SFN(2), SKP1(1), SKP2(2), SMAD2(2), SMAD3(1), SMAD4(5), SMC1A(2), SMC1B(9), TFDP1(3), TGFB1(1), TGFB2(3), TP53(147), WEE1(4), YWHAB(1), YWHAQ(1)	36188500	449	166	396	72	106	129	36	77	101	0	7.71e-06	1.000	1.000
254	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	81	AIFM1(1), AKT1(1), AKT3(3), APAF1(4), ATM(8), BAX(1), BCL2L1(1), BIRC2(1), BIRC3(3), CAPN1(2), CAPN2(2), CASP10(3), CASP7(2), CASP8(2), CASP9(3), CFLAR(2), CHP(2), CHUK(2), CSF2RB(5), DFFB(2), FADD(1), FAS(1), FASLG(1), IKBKB(2), IL1A(1), IL1B(1), IL1R1(1), IL1RAP(2), IL3(1), IRAK1(4), IRAK2(1), IRAK3(4), MAP3K14(1), NFKB1(2), NFKB2(2), NTRK1(4), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), RELA(3), TNF(1), TNFRSF10A(1), TNFRSF10B(1), TNFRSF1A(2), TP53(147), TRADD(1)	22180288	327	166	264	67	75	96	25	59	72	0	0.00364	1.000	1.000
255	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTB(1), ACTG1(2), ACTN1(2), ACTN2(10), ACTN3(2), ACTN4(5), AKT1(1), AKT3(3), AMOTL1(3), ASH1L(9), CASK(2), CDC42(1), CGN(5), CLDN1(2), CLDN10(4), CLDN11(1), CLDN16(4), CLDN17(1), CLDN18(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN4(1), CLDN5(1), CLDN6(1), CLDN8(1), CLDN9(3), CSDA(5), CSNK2A1(3), CTNNA1(1), CTNNA2(27), CTNNA3(17), CTNNB1(4), CTTN(5), EPB41(3), EPB41L1(3), EPB41L2(3), EPB41L3(20), EXOC3(3), EXOC4(3), F11R(1), GNAI1(3), GNAI3(1), HCLS1(3), HRAS(5), IGSF5(2), INADL(13), JAM2(2), KRAS(2), LLGL1(1), LLGL2(3), MAGI1(8), MAGI2(12), MAGI3(2), MLLT4(4), MPDZ(6), MPP5(4), MRAS(2), MYH1(24), MYH10(1), MYH11(8), MYH13(12), MYH14(6), MYH15(18), MYH2(33), MYH3(6), MYH4(21), MYH6(14), MYH7(13), MYH7B(8), MYH8(24), MYH9(13), MYL2(2), MYL9(1), MYLPF(1), NRAS(1), PARD3(8), PARD6A(1), PARD6G(1), PPM1J(1), PPP2R1A(8), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), PPP2R3A(3), PPP2R4(1), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCI(5), PRKCQ(4), PRKCZ(1), PTEN(16), RAB3B(2), RRAS2(2), SPTAN1(4), SYMPK(8), TJAP1(4), TJP1(9), TJP2(3), TJP3(2), VAPA(1), YES1(1)	51510780	557	165	554	160	158	193	39	92	75	0	0.201	1.000	1.000
256	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(3), ATM(8), BUB1(4), BUB1B(6), BUB3(2), CCNA1(1), CCNA2(1), CCNB1(2), CCNB2(1), CCNB3(11), CCND2(3), CCND3(1), CCNE1(3), CCNE2(2), CDAN1(3), CDC14A(1), CDC14B(2), CDC20(1), CDC25B(2), CDC25C(1), CDC6(6), CDC7(3), CDH1(3), CDKN1A(2), CDKN2A(26), CHEK1(5), CHEK2(3), DTX4(2), E2F1(2), E2F5(2), EP300(9), ESPL1(4), GADD45A(1), HDAC1(2), HDAC3(1), HDAC4(5), HDAC5(1), HDAC8(1), MAD1L1(7), MAD2L1(2), MCM2(1), MCM3(1), MCM4(5), MCM5(6), MCM6(3), MCM7(3), MDM2(2), MPEG1(6), MPL(2), ORC1L(3), ORC2L(1), ORC3L(2), ORC5L(3), PLK1(2), PRKDC(12), PTTG1(2), PTTG2(2), RB1(12), RBL1(5), SKP2(2), SMAD4(5), TBC1D8(1), TFDP1(3), TGFB1(1), TP53(147), WEE1(4)	29286580	381	163	328	57	76	112	32	66	95	0	1.22e-06	1.000	1.000
257	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), ADRA1A(2), ADRA1B(3), ADRA1D(3), ADRB1(1), ADRB2(4), ANXA6(5), ARRB1(2), ATP1A4(6), ATP1B2(1), ATP1B3(1), ATP2A2(3), ATP2A3(3), ATP2B1(4), ATP2B2(7), ATP2B3(3), CACNA1A(11), CACNA1B(10), CACNA1C(18), CACNA1D(6), CACNA1E(19), CACNA1S(7), CACNB1(1), CACNB3(2), CALM2(1), CALR(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CAMK4(3), CASQ1(1), CASQ2(3), CHRM2(9), CHRM3(5), CHRM4(1), CHRM5(3), GJA1(4), GJA4(1), GJA5(1), GJB2(1), GJB4(3), GNA11(1), GNAI3(1), GNAZ(3), GNB1(1), GNB2(2), GNB3(2), GNB4(3), GNB5(1), GNG12(1), GNG4(2), GNG5(1), GRK4(1), GRK5(1), GRK6(1), ITPR1(6), ITPR2(14), ITPR3(4), KCNB1(1), KCNJ3(11), KCNJ5(2), MIB1(2), NME7(3), PEA15(1), PKIB(1), PLCB3(4), PLN(1), PRKACB(3), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCQ(4), PRKCZ(1), PRKD1(11), RGS1(3), RGS10(1), RGS11(1), RGS16(1), RGS17(2), RGS18(1), RGS19(1), RGS20(1), RGS3(6), RGS5(3), RGS6(5), RGS7(14), RGS9(2), RYR1(28), RYR2(120), RYR3(52), SFN(2), SLC8A1(15), SLC8A3(3), USP5(2), YWHAB(1), YWHAQ(1)	50047107	615	161	611	189	136	257	41	114	65	2	0.0517	1.000	1.000
258	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(4), CD36(1), CD44(5), CD47(2), COL11A1(46), COL11A2(13), COL1A1(11), COL1A2(15), COL2A1(12), COL3A1(16), COL4A1(11), COL4A2(14), COL4A4(11), COL4A6(10), COL5A1(8), COL5A2(14), COL5A3(13), COL6A1(1), COL6A2(7), COL6A3(13), COL6A6(21), DAG1(2), FN1(21), FNDC1(8), FNDC3A(1), GP5(4), GP6(2), GP9(2), HMMR(2), HSPG2(11), IBSP(6), ITGA1(4), ITGA10(8), ITGA11(6), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGA7(4), ITGA8(14), ITGA9(2), ITGAV(4), ITGB1(5), ITGB3(4), ITGB4(8), ITGB6(1), ITGB7(1), ITGB8(5), LAMA1(17), LAMA2(23), LAMA3(11), LAMA4(17), LAMA5(7), LAMB1(6), LAMB2(3), LAMB3(3), LAMB4(6), LAMC1(7), LAMC2(5), LAMC3(5), RELN(34), SDC2(2), SDC3(2), SPP1(1), SV2A(3), SV2B(4), SV2C(4), THBS1(1), THBS2(16), THBS3(3), THBS4(1), TNC(14), TNN(21), TNR(26), TNXB(19), VWF(17)	59383761	672	160	670	199	180	272	43	102	75	0	0.264	1.000	1.000
259	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(3), BAK1(1), BAX(1), BTK(7), CAD(11), CASP10(3), CASP8(2), CASP8AP2(6), CD7(1), CDK2AP1(1), CSNK1A1(2), DAXX(3), EGFR(7), EPHB2(6), FADD(1), FAF1(1), FAIM2(1), IL1A(1), MAP2K4(1), MAP2K7(1), MAP3K1(3), MAP3K5(4), MAPK1(1), MAPK10(1), MAPK8(3), MAPK8IP1(2), MAPK8IP3(4), MAPK9(1), MET(4), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NFKBIL2(5), NR0B2(1), PFN2(1), PTPN13(9), RALBP1(1), ROCK1(5), SMPD1(4), TNFRSF6B(1), TP53(147), TPX2(1), TUFM(1)	19416390	270	160	220	46	41	85	25	55	64	0	0.000494	1.000	1.000
260	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ACTN1(2), ACTN2(10), ACTN3(2), ACTN4(5), APC(9), APC2(2), ARAF(3), ARHGEF1(2), ARHGEF12(5), ARHGEF4(3), ARHGEF6(2), ARHGEF7(3), ARPC1A(4), BAIAP2(2), BCAR1(6), BDKRB1(3), BDKRB2(3), BRAF(8), CD14(2), CDC42(1), CFL1(2), CFL2(1), CHRM2(9), CHRM3(5), CHRM4(1), CHRM5(3), CRKL(1), CYFIP1(5), CYFIP2(6), DIAPH1(1), DIAPH2(4), DIAPH3(5), DOCK1(4), EGF(6), EGFR(7), F2R(2), FGD1(3), FGD3(2), FGF10(2), FGF12(3), FGF14(2), FGF18(1), FGF19(1), FGF2(2), FGF22(1), FGF23(2), FGF3(1), FGF5(3), FGF6(2), FGF8(1), FGFR1(1), FGFR2(4), FGFR3(4), FGFR4(2), FN1(21), GIT1(1), GNA12(2), GNA13(1), GNG12(1), GRLF1(13), GSN(2), HRAS(5), IQGAP1(8), IQGAP2(6), IQGAP3(11), ITGA1(4), ITGA10(8), ITGA11(6), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGA7(4), ITGA8(14), ITGA9(2), ITGAD(7), ITGAE(4), ITGAL(1), ITGAM(7), ITGAV(4), ITGAX(9), ITGB1(5), ITGB2(5), ITGB3(4), ITGB4(8), ITGB6(1), ITGB7(1), ITGB8(5), KRAS(2), LIMK2(3), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MOS(4), MRAS(2), MSN(4), MYH10(1), MYH14(6), MYH9(13), MYL2(2), MYL9(1), MYLK(8), MYLK2(4), MYLPF(1), NCKAP1(7), NCKAP1L(12), NRAS(1), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(6), PDGFB(1), PDGFRA(10), PDGFRB(6), PFN2(1), PFN3(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PIP4K2A(3), PIP4K2B(2), PIP4K2C(3), PIP5K1A(4), PIP5K1B(2), PIP5K1C(2), PPP1CA(1), PPP1R12B(5), PTK2(6), PXN(3), RAC1(1), RAF1(1), RDX(2), ROCK1(5), ROCK2(3), RRAS2(2), SCIN(1), SLC9A1(3), SOS1(11), SOS2(7), SSH1(1), SSH2(8), SSH3(1), TIAM1(11), TIAM2(5), VAV1(7), VAV2(4), VAV3(1), VCL(2), WAS(3), WASF1(1), WASL(2)	73224440	653	157	635	189	206	219	28	127	73	0	0.106	1.000	1.000
261	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(3), ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), ARRB1(2), ATF2(3), ATF3(1), ATF4(2), ATP2A2(3), ATP2A3(3), CACNB3(2), CALM2(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CNN1(2), CORIN(11), CREB3(2), CRHR1(4), DGKZ(4), FOS(2), GABPA(2), GABPB2(2), GJA1(4), GNB1(1), GNB2(2), GNB3(2), GNB4(3), GNB5(1), GNG12(1), GNG4(2), GNG5(1), GRK4(1), GRK5(1), GRK6(1), GSTO1(1), GUCY1A3(7), IGFBP3(2), IGFBP6(2), IL1B(1), IL6(1), ITPR1(6), ITPR2(14), ITPR3(4), JUN(3), MIB1(2), MYL2(2), MYL4(1), MYLK2(4), NFKB1(2), NOS1(11), NOS3(2), OXTR(1), PDE4B(3), PDE4D(2), PKIB(1), PLCB3(4), PLCD1(1), PLCG1(3), PLCG2(5), PRKACB(3), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCQ(4), PRKCZ(1), PRKD1(11), RAMP2(1), RGS1(3), RGS10(1), RGS11(1), RGS16(1), RGS17(2), RGS18(1), RGS19(1), RGS20(1), RGS3(6), RGS5(3), RGS6(5), RGS7(14), RGS9(2), RYR1(28), RYR2(120), RYR3(52), SFN(2), SLC8A1(15), SP1(2), TNXB(19), USP5(2), YWHAB(1), YWHAQ(1)	46011111	549	157	543	164	135	216	40	99	57	2	0.0718	1.000	1.000
262	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(3), ABLIM1(2), ABLIM2(2), ABLIM3(3), ARHGEF12(5), CDC42(1), CDK5(1), CFL1(2), CFL2(1), CHP(2), CXCR4(5), DCC(15), DPYSL2(1), DPYSL5(8), EFNA3(1), EFNB1(3), EFNB2(2), EPHA1(3), EPHA2(2), EPHA3(11), EPHA4(1), EPHA5(16), EPHA6(14), EPHA7(9), EPHA8(6), EPHB1(13), EPHB2(6), EPHB3(8), EPHB4(3), EPHB6(5), FYN(5), GNAI1(3), GNAI3(1), HRAS(5), ITGB1(5), KRAS(2), L1CAM(2), LIMK2(3), LRRC4C(19), MAPK1(1), MAPK3(1), MET(4), NCK1(2), NCK2(2), NFAT5(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NGEF(1), NRAS(1), NRP1(5), NTN1(3), NTN4(2), NTNG1(1), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(6), PLXNA1(11), PLXNA2(3), PLXNA3(5), PLXNB1(3), PLXNB2(4), PLXNB3(4), PLXNC1(9), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PTK2(6), RAC1(1), RASA1(8), RGS3(6), ROBO1(10), ROBO2(9), ROBO3(8), ROCK1(5), ROCK2(3), SEMA3A(4), SEMA3B(1), SEMA3C(5), SEMA3D(3), SEMA3E(5), SEMA3F(2), SEMA3G(3), SEMA4A(1), SEMA4B(1), SEMA4C(2), SEMA4D(1), SEMA4F(6), SEMA5A(9), SEMA5B(6), SEMA6B(1), SEMA6C(5), SEMA6D(8), SEMA7A(1), SLIT1(5), SLIT2(15), SLIT3(10), SRGAP1(5), SRGAP2(5), SRGAP3(5), UNC5A(5), UNC5B(2), UNC5C(8), UNC5D(19)	52059313	505	156	504	192	111	199	34	92	68	1	0.941	1.000	1.000
263	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(3), ADORA2A(5), ADORA3(1), ADRA1A(2), ADRA1B(3), ADRA1D(3), ADRA2C(2), ADRB1(1), ADRB2(4), AGTR1(5), AGTR2(3), AVPR1A(3), AVPR1B(2), AVPR2(3), BDKRB1(3), BDKRB2(3), C3AR1(2), CCBP2(4), CCKAR(2), CCKBR(2), CCR1(3), CCR10(1), CCR2(1), CCR3(1), CCR4(3), CCR5(2), CCR6(2), CCR8(1), CCR9(1), CCRL1(3), CCRL2(1), CHML(2), CHRM2(9), CHRM3(5), CHRM4(1), CHRM5(3), CMKLR1(2), CNR1(5), CNR2(2), CX3CR1(3), CXCR3(1), CXCR4(5), DRD1(1), DRD2(4), DRD3(5), DRD4(1), DRD5(5), EDNRA(1), EDNRB(5), F2R(2), F2RL1(3), F2RL2(1), F2RL3(1), FPR1(1), FSHR(15), GALR1(5), GALT(1), GHSR(4), GPR17(4), GPR173(1), GPR174(6), GPR27(1), GPR35(1), GPR37(3), GPR37L1(2), GPR50(5), GPR6(2), GPR63(4), GPR77(2), GPR83(2), GPR85(2), GPR87(4), GRPR(3), HCRTR2(3), HRH1(3), HRH2(2), HRH3(1), HTR1A(8), HTR1B(3), HTR1E(5), HTR1F(3), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(3), HTR5A(4), HTR6(2), HTR7(4), LHCGR(9), MAS1(3), MC3R(2), MC4R(2), MC5R(3), MLNR(2), MTNR1A(1), MTNR1B(10), NMBR(3), NMUR2(2), NPY1R(3), NPY2R(4), NPY5R(4), NTSR1(4), NTSR2(4), OPN1SW(3), OPN3(2), OPRD1(2), OPRK1(1), OPRL1(2), OPRM1(6), OR10A5(2), OR11A1(4), OR12D3(4), OR1C1(9), OR1F1(1), OR1Q1(2), OR2H1(2), OR5V1(3), OR8B8(6), OXTR(1), P2RY1(3), P2RY10(5), P2RY13(1), P2RY14(3), P2RY2(3), P2RY6(2), PPYR1(4), PTAFR(3), PTGDR(6), PTGER2(2), PTGER4(2), PTGFR(5), PTGIR(1), RGR(1), RHO(1), SSTR1(3), SSTR2(2), SSTR3(2), SSTR4(2), SUCNR1(2), TBXA2R(2), TRHR(2)	32079932	423	154	423	160	84	180	28	86	45	0	0.266	1.000	1.000
264	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(4), BAK1(1), BAX(1), BCL2L1(1), BIRC2(1), BIRC3(3), CASP1(1), CASP10(3), CASP2(1), CASP4(4), CASP7(2), CASP8(2), CASP9(3), CHUK(2), DFFB(2), FADD(1), FAS(1), FASLG(1), GZMB(1), IKBKB(2), IRF1(1), IRF3(1), IRF4(2), IRF6(6), JUN(3), LTA(2), MAP2K4(1), MAP3K1(3), MAPK10(1), MDM2(2), MYC(1), NFKB1(2), NFKBIB(1), NFKBIE(1), PRF1(2), RELA(3), TNF(1), TNFRSF10B(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(3), TP53(147), TRADD(1), TRAF1(4), TRAF3(3)	15181256	232	153	181	42	33	62	23	49	65	0	0.00376	1.000	1.000
265	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(3), ACTN2(10), ACTN3(2), ACTN4(5), DES(3), DMD(34), FAM48A(2), MYBPC1(9), MYBPC3(6), MYH3(6), MYH6(14), MYH7(13), MYH8(24), MYL1(3), MYL2(2), MYL3(2), MYL4(1), MYL9(1), MYOM1(12), NEB(30), TNNI2(2), TNNI3(2), TNNT1(1), TNNT2(2), TNNT3(3), TPM1(1), TPM3(1), TTN(334), VIM(7)	36469866	535	150	533	173	142	200	36	100	54	3	0.949	1.000	1.000
266	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(4), BAK1(1), BAX(1), BCL2L1(1), BIRC2(1), BIRC3(3), CASP2(1), CASP7(2), CASP8(2), CASP9(3), FADD(1), FAS(1), FASLG(1), GZMB(1), JUN(3), MAP2K4(1), MAP3K1(3), MAP3K14(1), MAPK10(1), MCL1(2), MDM2(2), MYC(1), NFKB1(2), PARP1(3), PRF1(2), RELA(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TP53(147), TRADD(1), TRAF1(4)	9926909	203	148	152	39	29	56	20	42	56	0	0.0162	1.000	1.000
267	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), ADSL(1), ADSS(1), ADSSL1(2), AK2(1), AK5(7), AK7(3), ALLC(3), AMPD1(4), AMPD2(1), AMPD3(7), ATIC(1), CANT1(1), DCK(1), ENPP1(8), ENPP3(6), ENTPD1(1), ENTPD2(2), ENTPD3(1), ENTPD5(1), ENTPD6(4), ENTPD8(1), GART(3), GDA(7), GUCY1A2(12), GUCY1A3(7), GUCY1B3(4), GUCY2C(5), GUCY2D(2), GUCY2F(6), GUK1(2), HPRT1(1), IMPDH1(2), IMPDH2(1), NME4(1), NME7(3), NPR1(3), NPR2(4), NT5C1A(2), NT5C1B(2), NT5C2(3), NT5C3(3), NT5E(2), NUDT9(2), PAPSS2(1), PDE10A(9), PDE11A(12), PDE1A(2), PDE1C(13), PDE2A(4), PDE3B(5), PDE4A(1), PDE4B(3), PDE4C(4), PDE4D(2), PDE5A(4), PDE6H(3), PDE7A(1), PDE7B(1), PDE8A(5), PDE8B(3), PDE9A(2), PFAS(5), PKLR(4), PKM2(3), PNPT1(2), POLA1(7), POLD1(2), POLD2(1), POLD3(1), POLE(7), POLE2(2), POLE4(1), POLR1A(3), POLR1B(2), POLR1D(1), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(2), POLR3A(1), POLR3B(2), POLR3G(1), POLR3H(2), PPAT(2), PRIM1(3), PRIM2(16), PRPS1(2), PRPS1L1(3), PRPS2(1), RFC5(1), RRM1(1), RRM2(1), RRM2B(3), XDH(11)	43376730	382	142	381	138	96	148	21	60	57	0	0.863	1.000	1.000
268	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), ADRB1(1), CSNK1D(2), DRD1(1), DRD2(4), EGF(6), EGFR(7), GJA1(4), GJD2(2), GNA11(1), GNAI1(3), GNAI3(1), GNAS(6), GRM1(13), GRM5(12), GUCY1A2(12), GUCY1A3(7), GUCY1B3(4), GUCY2C(5), GUCY2D(2), GUCY2F(6), HRAS(5), HTR2A(3), HTR2B(1), HTR2C(5), ITPR1(6), ITPR2(14), ITPR3(4), KRAS(2), MAP2K1(2), MAP2K2(1), MAP2K5(1), MAPK1(1), MAPK3(1), MAPK7(1), NPR1(3), NPR2(4), NRAS(1), PDGFB(1), PDGFC(2), PDGFD(1), PDGFRA(10), PDGFRB(6), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKG1(6), PRKG2(4), PRKX(1), RAF1(1), SOS1(11), SOS2(7), TJP1(9), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(9), TUBA3D(2), TUBA3E(5), TUBA4A(1), TUBA8(1), TUBAL3(3), TUBB(1), TUBB1(1), TUBB2A(2), TUBB3(2), TUBB4(4), TUBB4Q(2), TUBB8(1)	35068163	364	141	361	108	86	134	29	71	44	0	0.159	1.000	1.000
269	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(1), AKT3(3), BCL2L1(1), CBL(3), CBLB(7), CCND1(1), CCND2(3), CCND3(1), CNTFR(1), CREBBP(17), CSF2RA(7), CSF2RB(5), CSF3R(7), EP300(9), EPOR(2), GH1(2), GH2(5), GHR(3), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IFNG(1), IFNGR1(4), IFNGR2(1), IL10(2), IL10RA(2), IL11RA(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), IL13RA1(2), IL13RA2(1), IL19(1), IL20RA(1), IL21(1), IL21R(3), IL22(2), IL22RA1(1), IL22RA2(1), IL23R(2), IL28B(2), IL28RA(1), IL2RB(2), IL2RG(1), IL3(1), IL4(2), IL4R(2), IL5RA(3), IL6(1), IL6R(1), IL6ST(1), IL7(1), IL7R(8), IL9R(6), JAK1(2), JAK2(4), JAK3(7), LEPR(15), LIFR(3), MPL(2), MYC(1), OSMR(5), PIAS1(5), PIAS2(2), PIAS3(3), PIAS4(2), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PIM1(2), PRL(1), PRLR(6), PTPN11(3), SOCS2(2), SOCS3(1), SOCS4(2), SOCS5(3), SOS1(11), SOS2(7), SPRED1(3), SPRED2(1), SPRY2(1), SPRY3(4), STAM(3), STAM2(2), STAT1(2), STAT2(1), STAT3(2), STAT4(5), STAT5A(2), STAT6(2), TPO(10), TYK2(8)	38492876	366	141	350	116	120	109	26	68	43	0	0.642	1.000	1.000
270	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1B(3), ACVR2A(4), AMHR2(7), BMPR1A(3), BMPR1B(1), BMPR2(1), CCL14(2), CCL16(1), CCL20(1), CCL26(2), CCL28(1), CCL3(2), CCL7(1), CCR1(3), CCR2(1), CCR3(1), CCR4(3), CCR5(2), CCR6(2), CCR8(1), CCR9(1), CD27(1), CD40(2), CD40LG(3), CNTFR(1), CSF1(2), CSF1R(3), CSF2RA(7), CSF2RB(5), CSF3R(7), CX3CR1(3), CXCL14(1), CXCL5(2), CXCR3(1), CXCR4(5), EDA2R(1), EDAR(2), EGF(6), EGFR(7), EPOR(2), FAS(1), FASLG(1), FLT1(11), FLT3(7), FLT4(5), GDF5(4), GH1(2), GH2(5), GHR(3), HGF(10), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IFNG(1), IFNGR1(4), IFNGR2(1), IL10(2), IL10RA(2), IL11RA(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), IL13RA1(2), IL17A(1), IL17RA(6), IL18R1(2), IL18RAP(4), IL19(1), IL1A(1), IL1B(1), IL1R1(1), IL1R2(3), IL1RAP(2), IL20RA(1), IL21(1), IL21R(3), IL22(2), IL22RA1(1), IL22RA2(1), IL23R(2), IL28B(2), IL28RA(1), IL2RB(2), IL2RG(1), IL3(1), IL4(2), IL4R(2), IL5RA(3), IL6(1), IL6R(1), IL6ST(1), IL7(1), IL7R(8), IL9R(6), INHBA(5), INHBB(1), INHBC(1), KDR(16), KIT(7), LEPR(15), LIFR(3), LTA(2), LTB(1), LTBR(1), MET(4), MPL(2), NGFR(1), OSMR(5), PDGFB(1), PDGFC(2), PDGFRA(10), PDGFRB(6), PF4(1), PLEKHO2(5), PRL(1), PRLR(6), TGFB1(1), TGFB2(3), TGFBR2(3), TNF(1), TNFRSF10A(1), TNFRSF10B(1), TNFRSF11A(2), TNFRSF11B(1), TNFRSF13B(2), TNFRSF17(1), TNFRSF18(1), TNFRSF19(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF21(3), TNFRSF6B(1), TNFRSF8(1), TNFRSF9(1), TNFSF11(1), TNFSF13(1), TNFSF14(1), TNFSF15(1), TNFSF18(1), TPO(10), VEGFC(6), XCL1(1), XCR1(2)	46853372	407	140	404	163	97	150	24	84	51	1	0.990	1.000	1.000
271	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(3), CADM1(2), CADM3(4), CD2(1), CD22(6), CD226(5), CD276(2), CD34(2), CD4(1), CD40(2), CD40LG(3), CD58(1), CD6(2), CD80(3), CD86(3), CD8A(2), CD8B(1), CD99(2), CDH1(3), CDH15(2), CDH2(10), CDH3(1), CDH4(6), CDH5(3), CLDN1(2), CLDN10(4), CLDN11(1), CLDN16(4), CLDN17(1), CLDN18(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN4(1), CLDN5(1), CLDN6(1), CLDN8(1), CLDN9(3), CNTN1(12), CNTN2(1), CNTNAP1(4), CNTNAP2(32), CTLA4(1), ESAM(4), F11R(1), GLG1(3), HLA-A(7), HLA-B(1), HLA-C(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(1), HLA-DOB(1), HLA-DPA1(2), HLA-DQA2(1), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), HLA-G(2), ICAM1(2), ICAM3(2), ICOS(2), ITGA4(4), ITGA6(7), ITGA8(14), ITGA9(2), ITGAL(1), ITGAM(7), ITGAV(4), ITGB1(5), ITGB2(5), ITGB7(1), ITGB8(5), JAM2(2), L1CAM(2), MADCAM1(1), MAG(4), NCAM1(4), NCAM2(15), NEGR1(2), NEO1(8), NFASC(7), NLGN1(15), NLGN2(1), NLGN3(4), NRCAM(6), NRXN1(23), NRXN2(10), NRXN3(10), PDCD1(2), PTPRC(7), PTPRF(7), PTPRM(6), PVR(1), PVRL1(3), PVRL3(3), SDC2(2), SDC3(2), SELE(4), SELL(2), SELP(11), SELPLG(1), SIGLEC1(9), VCAM1(5), VCAN(23)	39075264	438	139	437	176	138	151	32	77	39	1	0.983	1.000	1.000
272	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(2), ACACB(9), AKT1(1), AKT3(3), ARAF(3), BRAF(8), CALM2(1), CALML6(1), CBL(3), CBLB(7), CRKL(1), EXOC7(1), FASN(2), FBP2(1), FLOT1(1), FLOT2(1), G6PC(3), G6PC2(3), GCK(5), GYS1(1), GYS2(4), HRAS(5), IKBKB(2), INPP5D(8), INSR(10), IRS1(7), IRS2(2), IRS4(3), KRAS(2), LIPE(1), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(3), MAPK9(1), MKNK2(1), NRAS(1), PCK1(3), PCK2(1), PDE3A(8), PDE3B(5), PDPK1(1), PFKL(2), PFKM(6), PFKP(2), PHKA1(6), PHKA2(4), PHKB(6), PHKG1(2), PHKG2(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PKLR(4), PKM2(3), PPARGC1A(5), PPP1CA(1), PPP1R3A(16), PPP1R3C(2), PPP1R3D(2), PRKAA2(5), PRKAB2(1), PRKACB(3), PRKACG(1), PRKAG2(4), PRKAG3(3), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCI(5), PRKCZ(1), PRKX(1), PTPN1(1), PTPRF(7), PYGB(4), PYGL(3), PYGM(6), RAF1(1), RAPGEF1(4), RHEB(1), RPS6(1), RPS6KB1(1), RPS6KB2(1), SH2B2(1), SHC1(2), SHC2(5), SHC3(2), SHC4(5), SLC2A4(2), SOCS2(2), SOCS3(1), SOCS4(2), SORBS1(5), SOS1(11), SOS2(7), SREBF1(2), TRIP10(2), TSC1(5), TSC2(5)	42393088	379	139	365	123	121	131	23	52	51	1	0.478	1.000	1.000
273	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), ATF4(2), CACNA1C(18), CACNA1D(6), CACNA1F(10), CACNA1S(7), CALM2(1), CALML6(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CDC42(1), CGA(2), EGFR(7), FSHB(2), GNA11(1), GNAS(6), HBEGF(1), HRAS(5), ITPR1(6), ITPR2(14), ITPR3(4), JUN(3), KRAS(2), LHB(1), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP2K7(1), MAP3K1(3), MAP3K3(1), MAP3K4(4), MAPK1(1), MAPK10(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPK7(1), MAPK8(3), MAPK9(1), MMP14(2), MMP2(3), NRAS(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLD1(7), PLD2(2), PRKACB(3), PRKACG(1), PRKCA(5), PRKCD(2), PRKX(1), RAF1(1), SOS1(11), SOS2(7)	33804548	298	136	294	101	70	123	20	55	30	0	0.562	1.000	1.000
274	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(2), ACTN2(10), ACTN3(2), ACTN4(5), ARHGAP5(2), BCAR1(6), CD99(2), CDC42(1), CDH5(3), CLDN1(2), CLDN10(4), CLDN11(1), CLDN16(4), CLDN17(1), CLDN18(1), CLDN19(1), CLDN2(1), CLDN22(1), CLDN3(1), CLDN4(1), CLDN5(1), CLDN6(1), CLDN8(1), CLDN9(3), CTNNA1(1), CTNNA2(27), CTNNA3(17), CTNNB1(4), CTNND1(4), CXCR4(5), CYBB(6), ESAM(4), F11R(1), GNAI1(3), GNAI3(1), GRLF1(13), ICAM1(2), ITGA4(4), ITGAL(1), ITGAM(7), ITGB1(5), ITGB2(5), ITK(2), JAM2(2), MAPK11(2), MAPK13(2), MAPK14(1), MLLT4(4), MMP2(3), MMP9(5), MSN(4), MYL2(2), MYL9(1), MYLPF(1), NCF2(3), NCF4(1), NOX1(2), NOX3(6), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG1(3), PLCG2(5), PRKCA(5), PRKCG(9), PTK2(6), PTPN11(3), PXN(3), RAC1(1), RAP1A(1), RAP1B(1), RAPGEF3(1), RAPGEF4(6), RASSF5(1), RHOH(4), ROCK1(5), ROCK2(3), THY1(2), TXK(3), VASP(2), VAV1(7), VAV2(4), VAV3(1), VCAM1(5), VCL(2)	32908753	357	135	344	112	112	136	21	56	32	0	0.389	1.000	1.000
275	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM2(1), CALML6(1), CDS1(2), DGKA(3), DGKB(6), DGKD(6), DGKE(4), DGKG(3), DGKI(13), DGKQ(1), DGKZ(4), FN3K(1), IMPA1(2), INPP1(1), INPP4A(5), INPP4B(6), INPP5A(4), INPP5B(7), INPP5D(8), INPP5E(2), INPPL1(4), ITPK1(3), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(14), ITPR3(4), OCRL(8), PI4KA(8), PI4KB(1), PIK3C2A(7), PIK3C2B(7), PIK3C2G(8), PIK3C3(5), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PIP4K2A(3), PIP4K2B(2), PIP4K2C(3), PIP5K1A(4), PIP5K1B(2), PIP5K1C(2), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLCD1(1), PLCD3(1), PLCE1(14), PLCG1(3), PLCG2(5), PLCZ1(5), PRKCA(5), PRKCG(9), PTEN(16), SYNJ1(4), SYNJ2(4)	33122627	335	134	319	82	106	115	15	51	48	0	0.0119	1.000	1.000
276	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(10), ADCY8(18), ARAF(3), ATF4(2), BRAF(8), CACNA1C(18), CALM2(1), CALML6(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CAMK4(3), CHP(2), CREBBP(17), EP300(9), GRIA1(9), GRIA2(7), GRIN1(1), GRIN2A(16), GRIN2B(18), GRIN2C(3), GRIN2D(4), GRM1(13), GRM5(12), HRAS(5), ITPR1(6), ITPR2(14), ITPR3(4), KRAS(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PPP1CA(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), RAF1(1), RAP1A(1), RAP1B(1), RAPGEF3(1), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), RPS6KA6(5)	26447306	294	134	290	101	64	119	29	48	34	0	0.648	1.000	1.000
277	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(3), BRAF(8), C7orf16(2), CACNA1A(11), CRHR1(4), GNA11(1), GNA12(2), GNA13(1), GNAI1(3), GNAI3(1), GNAS(6), GNAZ(3), GRIA1(9), GRIA2(7), GRIA3(11), GRID2(15), GRM1(13), GRM5(12), GUCY1A2(12), GUCY1A3(7), GUCY1B3(4), GUCY2C(5), GUCY2D(2), GUCY2F(6), HRAS(5), IGF1(3), IGF1R(1), ITPR1(6), ITPR2(14), ITPR3(4), KRAS(2), LYN(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NOS1(11), NOS3(2), NPR1(3), NPR2(4), NRAS(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PPP2R1A(8), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), PRKCA(5), PRKCG(9), PRKG1(6), PRKG2(4), RAF1(1), RYR1(28)	29214472	324	133	322	98	81	118	28	52	45	0	0.218	1.000	1.000
278	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(3), ACTN1(2), AKT1(1), AKT3(3), ARHGEF6(2), ARHGEF7(3), BCAR1(6), BRAF(8), CDC42(1), CDKN2A(26), CSE1L(4), DOCK1(4), EPHB2(6), FYN(5), GRLF1(13), ILK(2), ITGA1(4), ITGA10(8), ITGA11(6), ITGA2(5), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGA7(4), ITGA8(14), ITGA9(2), ITGB3BP(1), MAP2K4(1), MAP2K7(1), MAP3K11(2), MAPK1(1), MAPK10(1), MAPK8(3), MAPK8IP1(2), MAPK8IP3(4), MAPK9(1), MRAS(2), MYLK(8), MYLK2(4), P4HB(5), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(6), PIK3CA(29), PIK3CB(4), PKLR(4), PLCG1(3), PLCG2(5), PTEN(16), PTK2(6), RAF1(1), RALA(3), RHO(1), ROCK1(5), ROCK2(3), SHC1(2), SOS1(11), SOS2(7), TLN1(6), TLN2(14), VASP(2), WAS(3), ZYX(1)	32497462	320	133	303	88	106	93	13	58	50	0	0.191	1.000	1.000
279	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(11), ABCA10(10), ABCA12(7), ABCA13(34), ABCA2(10), ABCA3(4), ABCA4(12), ABCA5(5), ABCA6(7), ABCA7(4), ABCA8(6), ABCA9(13), ABCB1(18), ABCB10(6), ABCB11(6), ABCB4(8), ABCB5(14), ABCB6(3), ABCB7(2), ABCB8(1), ABCB9(3), ABCC1(5), ABCC10(8), ABCC11(6), ABCC12(15), ABCC2(6), ABCC3(3), ABCC4(1), ABCC5(8), ABCC6(1), ABCC8(6), ABCC9(10), ABCD1(3), ABCD2(12), ABCD4(1), ABCG1(1), ABCG2(2), ABCG4(4), ABCG5(2), ABCG8(7), CFTR(8), TAP1(3), TAP2(1)	31371140	297	130	295	102	81	98	18	69	29	2	0.546	1.000	1.000
280	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	125	ARAF(3), BRAF(8), CD244(3), CHP(2), FAS(1), FASLG(1), FCER1G(1), FCGR3A(4), FCGR3B(2), FYN(5), GZMB(1), HLA-A(7), HLA-B(1), HLA-C(1), HLA-G(2), HRAS(5), ICAM1(2), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IFNG(1), IFNGR1(4), IFNGR2(1), ITGAL(1), ITGB2(5), KIR2DL1(2), KIR2DL3(4), KIR2DL4(1), KIR3DL1(6), KIR3DL2(1), KLRC1(1), KLRC3(2), KLRD1(1), KRAS(2), LCK(3), LCP2(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NCR1(6), NCR2(1), NFAT5(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NRAS(1), PAK1(2), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG1(3), PLCG2(5), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRF1(2), PRKCA(5), PRKCG(9), PTPN11(3), RAC1(1), RAF1(1), SH2D1A(2), SHC1(2), SHC2(5), SHC3(2), SHC4(5), SOS1(11), SOS2(7), SYK(1), TNF(1), TNFRSF10A(1), TNFRSF10B(1), TYROBP(3), ULBP1(2), ULBP3(1), VAV1(7), VAV2(4), VAV3(1), ZAP70(5)	29854704	308	129	293	89	103	110	16	44	34	1	0.176	1.000	1.000
281	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1B(3), ACVRL1(3), AKT1(1), BMPR1A(3), BMPR2(1), BUB1(4), CDKL1(1), CDKL2(2), CDS1(2), CLK1(3), CLK2(2), CLK4(2), COL4A3BP(3), CSNK2A1(3), DGKA(3), DGKB(6), DGKD(6), DGKE(4), DGKG(3), DGKQ(1), DGKZ(4), IMPA1(2), INPP1(1), INPP4A(5), INPP4B(6), INPP5A(4), INPPL1(4), ITPKA(1), ITPKB(6), MOS(4), NEK1(3), OCRL(8), PAK4(1), PIK3C2A(7), PIK3C2B(7), PIK3C2G(8), PIK3CA(29), PIK3CB(4), PIK3CG(19), PIM2(2), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLCD1(1), PLCG1(3), PLCG2(5), PLK3(3), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCQ(4), PRKCZ(1), PRKD1(11), PRKG1(6), RAF1(1), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), RPS6KA4(2), RPS6KB1(1), STK11(3), VRK1(1)	30000877	287	129	273	74	93	97	19	46	32	0	0.0941	1.000	1.000
282	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(2), ACTB(1), ACTG1(2), ACTN1(2), ACTN2(10), ACTN3(2), ACTN4(5), ACVR1B(3), ACVR1C(4), BAIAP2(2), CDC42(1), CDH1(3), CREBBP(17), CSNK2A1(3), CTNNA1(1), CTNNA2(27), CTNNA3(17), CTNNB1(4), CTNND1(4), EGFR(7), EP300(9), ERBB2(2), FARP2(7), FER(3), FGFR1(1), FYN(5), IGF1R(1), INSR(10), IQGAP1(8), LEF1(3), LMO7(7), MAP3K7(2), MAPK1(1), MAPK3(1), MET(4), MLLT4(4), NLK(2), PARD3(8), PTPN1(1), PTPRB(17), PTPRF(7), PTPRJ(4), PTPRM(6), PVRL1(3), PVRL3(3), PVRL4(6), RAC1(1), SMAD2(2), SMAD3(1), SMAD4(5), SNAI1(4), SNAI2(3), SORBS1(5), SSX2IP(2), TCF7(1), TCF7L2(1), TGFBR2(3), TJP1(9), VCL(2), WAS(3), WASF1(1), WASF3(1), WASL(2), YES1(1)	31739977	289	128	287	95	79	95	19	61	35	0	0.784	1.000	1.000
283	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADSL(1), ADSS(1), AK2(1), AK5(7), ALLC(3), AMPD1(4), AMPD2(1), AMPD3(7), ATIC(1), ATP5A1(3), ATP5B(2), ATP5C1(3), ATP5G2(2), ATP5G3(1), CANT1(1), DCK(1), ENPP1(8), ENPP3(6), ENTPD1(1), ENTPD2(2), GART(3), GDA(7), GUCY1A2(12), GUCY1A3(7), GUCY1B3(4), GUCY2C(5), GUCY2D(2), GUCY2F(6), GUK1(2), HPRT1(1), IMPDH1(2), IMPDH2(1), NPR1(3), NPR2(4), NT5E(2), PAPSS2(1), PDE1A(2), PDE4A(1), PDE4B(3), PDE4C(4), PDE4D(2), PDE5A(4), PDE6B(3), PDE6C(1), PDE7B(1), PDE8A(5), PDE9A(2), PFAS(5), PKLR(4), PKM2(3), POLB(1), POLD1(2), POLD2(1), POLE(7), POLG(2), POLL(2), POLQ(19), POLR1B(2), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(2), POLRMT(2), PPAT(2), PRPS1(2), PRPS1L1(3), PRPS2(1), RRM1(1), RRM2(1)	34024956	285	128	285	93	75	105	16	54	35	0	0.504	1.000	1.000
284	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), AKAP1(2), AKAP11(8), AKAP12(4), AKAP3(8), AKAP4(6), AKAP5(1), AKAP6(15), AKAP7(2), AKAP8(5), AKAP9(11), ARHGEF1(2), CALM2(1), CHMP1B(1), GNA11(1), GNA12(2), GNA13(1), GNA14(3), GNA15(1), GNAI3(1), GNAL(1), GNAZ(3), GNB1(1), GNB2(2), GNB3(2), GNB5(1), GNG12(1), GNG4(2), GNG5(1), HRAS(5), ITPR1(6), KCNJ3(11), KRAS(2), NRAS(1), PDE1A(2), PDE1B(3), PDE1C(13), PDE4A(1), PDE4B(3), PDE4C(4), PDE4D(2), PDE7A(1), PDE7B(1), PDE8A(5), PDE8B(3), PLCB3(4), PPP3CA(4), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCI(5), PRKCQ(4), PRKCZ(1), PRKD1(11), PRKD3(2), SLC9A1(3), USP5(2)	31035628	291	125	289	68	84	103	19	50	35	0	0.0108	1.000	1.000
285	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	108	A4GNT(6), ALG1(1), ALG10B(1), ALG12(1), ALG13(8), ALG2(3), ALG6(2), ALG8(1), ALG9(1), B3GNT2(1), B3GNT6(1), B3GNT7(1), B4GALT1(1), B4GALT3(3), B4GALT4(3), B4GALT5(2), C1GALT1C1(1), CHPF(2), CHST1(3), CHST11(2), CHST12(1), CHST2(5), CHST3(2), CHST4(2), CHST6(5), CHSY1(2), DDOST(1), EXT1(2), EXT2(1), EXTL1(5), EXTL2(1), EXTL3(1), FUT8(2), GALNT1(2), GALNT10(3), GALNT11(2), GALNT12(3), GALNT13(14), GALNT14(4), GALNT2(2), GALNT3(3), GALNT5(7), GALNT6(2), GALNT8(3), GALNT9(1), GALNTL1(4), GALNTL4(4), GALNTL5(3), GANAB(5), GCNT1(3), GCNT3(2), HS3ST2(2), HS3ST3A1(1), HS3ST5(4), HS6ST1(5), HS6ST3(3), MAN1A1(4), MAN1A2(5), MAN1C1(3), MAN2A1(5), MGAT1(2), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(6), MGAT5B(3), NDST1(4), NDST2(2), NDST3(4), NDST4(13), OGT(2), RPN1(1), ST3GAL1(4), ST3GAL4(2), ST6GAL1(2), ST6GALNAC1(3), STT3B(1), UST(1), WBSCR17(12), XYLT1(6)	29153233	250	125	248	87	67	103	18	39	23	0	0.612	1.000	1.000
286	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	67	A2M(9), BDKRB1(3), BDKRB2(3), C1QA(2), C1QB(2), C1R(3), C1S(3), C2(2), C3(5), C3AR1(2), C4BPA(2), C5(1), C5AR1(4), C6(18), C7(12), C8A(7), C8B(4), C9(3), CD46(2), CD55(1), CFB(3), CFH(7), CFI(3), CPB2(3), CR1(7), CR2(12), F10(3), F11(3), F12(1), F13A1(6), F13B(13), F2R(2), F3(1), F5(19), F7(2), F8(10), F9(7), FGA(5), FGB(4), FGG(2), KLKB1(7), KNG1(9), MASP1(10), MASP2(1), MBL2(4), PLAT(1), PLAU(2), PLAUR(2), PLG(2), PROS1(5), SERPINA1(1), SERPINA5(3), SERPINC1(7), SERPIND1(2), SERPINF2(3), SERPING1(3), VWF(17)	24083078	280	125	280	84	73	108	22	49	27	1	0.447	1.000	1.000
287	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(1), AKT3(3), BCL2L1(1), CDC42(1), CDKN2A(26), CREB1(1), CREB3(2), CREB5(3), EBP(1), ERBB4(13), F2RL2(1), GAB1(3), GADD45A(1), GSK3A(3), IGF1(3), INPPL1(4), IRS1(7), IRS2(2), IRS4(3), MET(4), MYC(1), NOLC1(4), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(6), PARD3(8), PARD6A(1), PDK1(1), PIK3CA(29), PIK3CD(4), PPP1R13B(5), PREX1(14), PTEN(16), PTK2(6), PTPN1(1), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), RPS6KB1(1), SFN(2), SHC1(2), SLC2A4(2), SOS1(11), SOS2(7), TSC1(5), TSC2(5), YWHAB(1), YWHAQ(1)	20439040	232	124	215	59	76	68	10	35	43	0	0.142	1.000	1.000
288	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(6), AMY2B(7), ASCC3(10), ATP13A2(1), DDX18(2), DDX19A(1), DDX23(3), DDX4(2), DDX41(2), DDX50(1), DDX51(1), DDX52(1), DDX54(3), DDX55(1), DDX56(1), ENPP1(8), ENPP3(6), ENTPD7(2), EP400(9), ERCC3(1), G6PC(3), G6PC2(3), GANC(4), GBA(4), GBA3(11), GBE1(2), GCK(5), GPI(5), GUSB(2), GYS1(1), GYS2(4), HK1(2), HK2(5), HK3(5), IFIH1(4), MGAM(5), MOV10L1(7), NUDT8(1), PGM1(1), PYGB(4), PYGL(3), PYGM(6), RAD54L(1), SETX(12), SI(46), SKIV2L2(2), SMARCA2(4), TREH(1), UGDH(2), UGP2(4), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(4), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(4), UGT2B11(5), UGT2B15(3), UGT2B28(5), UGT2B4(8), UGT2B7(2), UXS1(4)	32566251	285	123	285	80	69	104	26	53	33	0	0.277	1.000	1.000
289	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(9), ASH2L(4), CARM1(1), CTCFL(2), DOT1L(5), EED(2), EHMT1(5), EHMT2(1), EZH1(4), EZH2(4), FBXO11(6), HCFC1(1), HSF4(1), JMJD6(1), KDM6A(7), MEN1(3), MLL(5), MLL2(42), MLL3(30), MLL4(10), MLL5(4), NSD1(10), OGT(2), PPP1CA(1), PRDM2(6), PRDM7(1), PRDM9(14), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), RBBP5(1), SATB1(4), SETD1A(8), SETD2(5), SETD8(1), SETDB1(3), SMYD3(1), STK38(4), SUV39H1(2), SUV39H2(2), SUV420H1(6), SUZ12(4), WHSC1(1), WHSC1L1(16)	31533699	252	122	251	61	69	77	11	37	57	1	0.158	1.000	1.000
290	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(1), AKT3(3), BCAR1(6), CAPN1(2), CAPN10(4), CAPN11(2), CAPN2(2), CAPN3(8), CAPN5(2), CAPN6(7), CAPN7(1), CAPN9(2), CAV2(1), CAV3(1), CDC42(1), DOCK1(4), FYN(5), ILK(2), ITGA10(8), ITGA11(6), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGA7(4), ITGA8(14), ITGA9(2), ITGAD(7), ITGAE(4), ITGAL(1), ITGAM(7), ITGAV(4), ITGAX(9), ITGB1(5), ITGB2(5), ITGB3(4), ITGB4(8), ITGB6(1), ITGB7(1), ITGB8(5), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K6(2), MAPK10(1), MAPK4(2), MAPK6(4), MAPK7(1), MYLK2(4), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PDPK1(1), PIK3R2(4), PTK2(6), PXN(3), RAC1(1), RAP1B(1), RAPGEF1(4), RHO(1), ROCK1(5), ROCK2(3), SDCCAG8(6), SHC1(2), SHC3(2), SORBS1(5), SOS1(11), TLN1(6), TNS1(5), VASP(2), VAV2(4), VAV3(1), VCL(2), ZYX(1)	35619810	272	122	271	102	77	103	20	47	25	0	0.884	1.000	1.000
291	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(10), ADCY2(18), ADCY3(7), ADCY4(4), ADCY5(2), ADCY6(2), ADCY7(7), ADCY8(18), ADCY9(3), CALM2(1), CALML6(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CREB1(1), CREB3(2), CREB3L2(2), CREB3L3(1), CREB3L4(2), CREBBP(17), CTNNB1(4), DCT(4), DVL1(3), DVL3(2), EDNRB(5), EP300(9), FZD1(1), FZD10(2), FZD2(1), FZD3(5), FZD4(1), FZD6(3), FZD7(3), FZD8(1), FZD9(2), GNAI1(3), GNAI3(1), GNAS(6), HRAS(5), KIT(7), KRAS(2), LEF1(3), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), POMC(2), PRKACB(3), PRKACG(1), PRKCA(5), PRKCG(9), PRKX(1), RAF1(1), TCF7(1), TCF7L2(1), TYR(10), TYRP1(2), WNT1(1), WNT10A(1), WNT10B(4), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT3A(2), WNT5A(1), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT9A(1), WNT9B(1)	28796144	270	119	268	86	53	114	25	53	25	0	0.336	1.000	1.000
292	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1B(3), ACVR1C(4), ACVR2A(4), ACVRL1(3), AMHR2(7), BMP4(1), BMP5(8), BMPR1A(3), BMPR1B(1), BMPR2(1), CDKN2B(1), CHRD(6), COMP(2), CREBBP(17), CUL1(4), DCN(1), E2F5(2), EP300(9), GDF5(4), GDF6(3), ID2(1), ID4(1), IFNG(1), INHBA(5), INHBB(1), INHBC(1), LEFTY2(3), LTBP1(16), MAPK1(1), MAPK3(1), MYC(1), NODAL(3), PITX2(3), PPP2R1A(8), PPP2R1B(2), PPP2R2A(1), PPP2R2B(1), PPP2R2C(2), RBL1(5), RBL2(8), RBX1(1), ROCK1(5), ROCK2(3), RPS6KB1(1), RPS6KB2(1), SKP1(1), SMAD1(3), SMAD2(2), SMAD3(1), SMAD4(5), SMAD7(2), SMAD9(1), SMURF1(2), SP1(2), TFDP1(3), TGFB1(1), TGFB2(3), TGFBR2(3), THBS1(1), THBS2(16), THBS3(3), THBS4(1), TNF(1), ZFYVE16(3), ZFYVE9(6)	26188844	220	118	218	66	62	76	14	38	30	0	0.496	1.000	1.000
293	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(3), ABL2(7), AKT1(1), AKT3(3), ARAF(3), AREG(3), BRAF(8), BTC(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CBL(3), CBLB(7), CDKN1A(2), CRKL(1), EGF(6), EGFR(7), ERBB2(2), ERBB3(4), ERBB4(13), EREG(1), GAB1(3), HBEGF(1), HRAS(5), JUN(3), KRAS(2), MAP2K1(2), MAP2K2(1), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(3), MAPK9(1), MYC(1), NCK1(2), NCK2(2), NRAS(1), NRG1(3), NRG2(3), NRG3(9), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(6), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG1(3), PLCG2(5), PRKCA(5), PRKCG(9), PTK2(6), RAF1(1), RPS6KB1(1), RPS6KB2(1), SHC1(2), SHC2(5), SHC3(2), SHC4(5), SOS1(11), SOS2(7), STAT5A(2), TGFA(1)	27210270	270	116	254	74	92	97	11	39	31	0	0.146	1.000	1.000
294	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(1), AKT3(3), CARD11(5), CBL(3), CBLB(7), CD3D(1), CD4(1), CD40LG(3), CD8A(2), CD8B(1), CDC42(1), CHP(2), CHUK(2), CTLA4(1), FOS(2), FYN(5), GRAP2(1), HRAS(5), ICOS(2), IFNG(1), IKBKB(2), IL10(2), IL4(2), ITK(2), JUN(3), KRAS(2), LCK(3), LCP2(2), MALT1(1), MAP3K14(1), NCK1(2), NCK2(2), NFAT5(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NRAS(1), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(6), PDCD1(2), PDK1(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRKCQ(4), PTPRC(7), RASGRP1(1), SOS1(11), SOS2(7), TEC(4), TNF(1), VAV1(7), VAV2(4), VAV3(1), ZAP70(5)	26889196	249	113	234	63	88	76	16	40	29	0	0.0940	1.000	1.000
295	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(1), AKT3(3), BLNK(1), BTK(7), CARD11(5), CD19(2), CD22(6), CD79A(1), CD81(2), CHP(2), CHUK(2), CR2(12), FCGR2B(3), FOS(2), HRAS(5), IKBKB(2), INPP5D(8), JUN(3), KRAS(2), LILRB3(4), LYN(2), MALT1(1), NFAT5(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NRAS(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLCG2(5), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), RAC1(1), RASGRP3(8), SYK(1), VAV1(7), VAV2(4), VAV3(1)	19725860	209	112	194	55	70	65	13	31	30	0	0.134	1.000	1.000
296	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(1), AKT3(3), BTK(7), FCER1A(4), FCER1G(1), FYN(5), GAB2(1), HRAS(5), IL3(1), IL4(2), INPP5D(8), KRAS(2), LCP2(2), LYN(2), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(3), MAPK9(1), MS4A2(4), NRAS(1), PDK1(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLCG1(3), PLCG2(5), PRKCA(5), PRKCD(2), PRKCE(3), RAC1(1), RAF1(1), SOS1(11), SOS2(7), SYK(1), TNF(1), VAV1(7), VAV2(4), VAV3(1)	19091815	212	112	198	52	68	73	17	27	27	0	0.0570	1.000	1.000
297	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	FN3K(1), IMPA1(2), INPP1(1), INPP4A(5), INPP4B(6), INPP5A(4), INPP5B(7), INPP5E(2), INPPL1(4), IPMK(2), ITPK1(3), ITPKA(1), ITPKB(6), MIOX(1), OCRL(8), PI4KA(8), PI4KB(1), PIK3C3(5), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIP4K2A(3), PIP4K2B(2), PIP4K2C(3), PIP5K1A(4), PIP5K1B(2), PIP5K1C(2), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLCD1(1), PLCD3(1), PLCE1(14), PLCG1(3), PLCG2(5), PLCZ1(5), PTEN(16), SYNJ1(4), SYNJ2(4)	19697222	216	110	201	52	72	66	7	38	33	0	0.0376	1.000	1.000
298	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(8), CD14(2), CD19(2), CD1A(5), CD1B(6), CD1C(5), CD1D(4), CD1E(4), CD2(1), CD22(6), CD33(3), CD34(2), CD36(1), CD37(3), CD38(2), CD3D(1), CD4(1), CD44(5), CD5(2), CD55(1), CD7(1), CD8A(2), CD8B(1), CD9(1), CR1(7), CR2(12), CSF1(2), CSF1R(3), CSF2RA(7), CSF3R(7), DNTT(2), EPOR(2), FCER2(1), FCGR1A(1), FLT3(7), GP5(4), GP9(2), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), IL11RA(1), IL1A(1), IL1B(1), IL1R1(1), IL1R2(3), IL3(1), IL4(2), IL4R(2), IL5RA(3), IL6(1), IL6R(1), IL7(1), IL7R(8), IL9R(6), ITGA1(4), ITGA2(5), ITGA2B(2), ITGA3(1), ITGA4(4), ITGA5(2), ITGA6(7), ITGAM(7), ITGB3(4), KIT(7), MME(10), MS4A1(2), TFRC(2), TNF(1), TPO(10)	21663912	231	109	230	81	51	86	11	56	27	0	0.830	1.000	1.000
299	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(1), AKT3(3), BCR(2), BTK(7), CD19(2), CDKN2A(26), FLOT1(1), FLOT2(1), GAB1(3), ITPR1(6), ITPR2(14), ITPR3(4), LYN(2), NR0B2(1), PDK1(1), PHF11(2), PIK3CA(29), PITX2(3), PLCG2(5), PPP1R13B(5), PREX1(14), PTEN(16), PTPRC(7), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), RPS6KB1(1), SYK(1), TEC(4), VAV1(7)	14690086	178	109	160	43	62	47	8	27	34	0	0.0875	1.000	1.000
300	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(1), AKT3(3), CASP8(2), CCL3(2), CD14(2), CD40(2), CD80(3), CD86(3), CHUK(2), FADD(1), FOS(2), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), IFNAR1(2), IFNB1(2), IKBKB(2), IKBKE(3), IL12A(1), IL12B(3), IL1B(1), IL6(1), IRAK1(4), IRF3(1), JUN(3), LBP(4), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP2K7(1), MAP3K7(2), MAPK1(1), MAPK10(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(3), MAPK9(1), NFKB1(2), NFKB2(2), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), RAC1(1), RELA(3), SPP1(1), STAT1(2), TBK1(3), TLR1(2), TLR2(3), TLR3(2), TLR4(10), TLR5(2), TLR7(3), TLR8(4), TLR9(2), TNF(1), TOLLIP(1), TRAF3(3), TRAF6(5)	23722982	206	107	191	65	80	57	11	34	24	0	0.480	1.000	1.000
301	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(3), AKT1(1), BDKRB2(3), CALM2(1), CHRNA1(4), FLT1(11), FLT4(5), KDR(16), NOS3(2), PDE2A(4), PDE3A(8), PDE3B(5), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKG1(6), PRKG2(4), RYR2(120), SLC7A1(4), SYT1(4)	10823358	212	107	210	62	45	84	18	37	27	1	0.266	1.000	1.000
302	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(1), AKT3(3), CASP9(3), CDC42(1), CHP(2), HRAS(5), KDR(16), KRAS(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPKAPK2(2), MAPKAPK3(1), NFAT5(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NOS3(2), NRAS(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLCG1(3), PLCG2(5), PPP3CA(4), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(4), PRKCA(5), PRKCG(9), PTGS2(1), PTK2(6), PXN(3), RAC1(1), RAF1(1), SH2D2A(2), SHC2(5), SPHK2(1)	19054474	212	106	197	64	76	74	12	24	26	0	0.289	1.000	1.000
303	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	91	CD2BP2(3), CDC40(2), CLK2(2), CLK3(1), CLK4(2), COL2A1(12), CPSF1(4), CPSF2(3), CPSF3(2), CPSF4(2), CSTF2(2), CSTF2T(3), CSTF3(1), DDX1(6), DHX15(3), DHX16(3), DHX38(2), DHX8(2), DHX9(5), DICER1(13), FUS(1), METTL3(1), NCBP1(2), NONO(1), NXF1(2), PAPOLA(1), POLR2A(2), PPM1G(1), PRPF3(1), PRPF4(2), PRPF4B(6), PRPF8(7), PSKH1(1), PTBP2(3), RBM17(1), RBM5(2), RNMT(2), RNPS1(1), SF3A1(1), SF3A2(2), SF3A3(2), SF3B1(4), SF3B2(4), SF3B4(1), SF4(4), SFRS12(1), SFRS14(5), SFRS2(2), SFRS6(1), SFRS7(2), SFRS8(2), SFRS9(1), SNRPA(2), SNRPA1(1), SNRPB(3), SNRPD1(2), SNRPD2(1), SNRPD3(1), SNRPF(1), SNRPN(5), SPOP(1), SRPK1(3), SRPK2(1), SRRM1(4), SUPT5H(2), U2AF2(1), XRN2(3)	27886092	173	106	171	44	46	63	11	34	19	0	0.293	1.000	1.000
304	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(5), AGTR2(3), ATP8A1(10), AVPR1A(3), AVPR1B(2), AVPR2(3), BDKRB1(3), BDKRB2(3), C3AR1(2), CCKAR(2), CCKBR(2), CCR1(3), CCR10(1), CCR2(1), CCR3(1), CCR4(3), CCR5(2), CCR6(2), CCR8(1), CX3CR1(3), CXCR3(1), CXCR4(5), EDNRA(1), EDNRB(5), FPR1(1), FSHR(15), GALR1(5), GALT(1), GHSR(4), GPR77(2), GRPR(3), LHCGR(9), MC2R(2), MC3R(2), MC4R(2), MC5R(3), NMBR(3), NPY1R(3), NPY2R(4), NPY5R(4), NTSR1(4), NTSR2(4), OPRD1(2), OPRK1(1), OPRL1(2), OPRM1(6), OXTR(1), PPYR1(4), SSTR1(3), SSTR2(2), SSTR3(2), SSTR4(2), TACR1(3), TACR2(1), TACR3(4), TRHR(2), TSHR(5)	13793598	178	105	178	70	30	72	11	37	28	0	0.597	1.000	1.000
305	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(1), AKT3(3), BRD4(3), CAP1(2), CBL(3), CDC42(1), CDKN2A(26), F2RL2(1), FLOT1(1), FLOT2(1), GSK3A(3), INPPL1(4), IRS1(7), IRS2(2), IRS4(3), LNPEP(2), MAPK1(1), MAPK3(1), PARD3(8), PARD6A(1), PDK1(1), PIK3CA(29), PIK3CD(4), PIK3R1(2), PPYR1(4), PTEN(16), PTPN1(1), RAF1(1), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), RPS6KB1(1), SERPINB6(4), SFN(2), SHC1(2), SLC2A4(2), SORBS1(5), SOS1(11), SOS2(7), YWHAB(1), YWHAQ(1)	15695994	178	104	161	37	65	44	7	28	34	0	0.0339	1.000	1.000
306	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	53	ADORA3(1), ALG6(2), CCKBR(2), CCR2(1), CCR3(1), CCR5(2), CELSR1(11), CELSR2(8), CELSR3(9), CHRM2(9), CHRM3(5), CXCR3(1), DRD4(1), EDNRA(1), EMR2(4), EMR3(5), F2R(2), FSHR(15), GHRHR(4), GPR116(5), GPR132(1), GPR133(3), GPR135(2), GPR143(2), GPR17(4), GPR18(2), GPR55(1), GPR56(1), GPR61(2), GPR77(2), GRM1(13), GRPR(3), HRH4(4), LGR6(1), LPHN2(7), LPHN3(17), LTB4R2(1), NTSR1(4), OR2M4(4), OR8G2(3), P2RY13(1), PTGFR(5), SMO(1), SSTR2(2), TAAR5(5), TSHR(5), VN1R1(4)	17564572	189	102	189	65	52	66	14	39	18	0	0.273	1.000	1.000
307	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(1), AKT3(3), BCR(2), BLNK(1), BTK(7), CD19(2), CD22(6), CD81(2), CR2(12), DAG1(2), FLOT1(1), FLOT2(1), GSK3A(3), INPP5D(8), ITPR1(6), ITPR2(14), ITPR3(4), LYN(2), MAP4K1(3), MAPK1(1), MAPK3(1), NFATC1(3), NFATC2(4), NR0B2(1), PDK1(1), PIK3CA(29), PIK3CD(4), PIK3R1(2), PLCG2(5), PPP1R13B(5), PPP3CA(4), PPP3CB(4), PPP3CC(2), PTPRC(7), RAF1(1), SHC1(2), SOS1(11), SOS2(7), SYK(1), VAV1(7)	19644866	182	102	168	59	62	58	8	31	23	0	0.553	1.000	1.000
308	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	AKT1(1), AKT3(3), ARHGAP1(1), ARHGAP4(2), ARHGEF11(8), BTK(7), CDC42(1), CFL1(2), CFL2(1), GDI1(2), GDI2(2), INPPL1(4), ITPR1(6), ITPR2(14), ITPR3(4), MYLK(8), MYLK2(4), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(6), PDK1(1), PIK3CA(29), PIK3CD(4), PIK3CG(19), PIK3R1(2), PITX2(3), PPP1R13B(5), PTEN(16), RACGAP1(3), RHO(1), ROCK1(5), ROCK2(3), WASF1(1), WASL(2)	18670087	176	101	160	46	52	59	8	28	29	0	0.141	1.000	1.000
309	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(1), CABIN1(5), CALM2(1), CAMK2B(2), CAMK4(3), CDKN1A(2), CNR1(5), CREBBP(17), CSNK2A1(3), CTLA4(1), EGR2(6), EGR3(2), EP300(9), FCER1A(4), FCGR3A(4), FKBP1B(1), FOS(2), FOSL1(1), GATA3(6), GRLF1(13), GSK3A(3), HRAS(5), ICOS(2), IFNA1(1), IFNB1(2), IFNG(1), IL10(2), IL1B(1), IL3(1), IL4(2), IL6(1), ITK(2), KPNA5(2), MAP2K7(1), MAPK14(1), MAPK8(3), MAPK9(1), MEF2A(3), MEF2D(3), MYF5(7), NCK2(2), NFAT5(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NPPB(1), NUP214(5), OPRD1(2), P2RX7(2), PAK1(2), PPP3CB(4), PPP3CC(2), PPP3R1(1), PTPRC(7), RELA(3), SFN(2), SLA(2), SP1(2), SP3(1), TGFB1(1), TNF(1), TRPV6(3), VAV1(7), VAV2(4), VAV3(1), XPO5(2)	24071734	211	100	209	62	54	79	15	37	26	0	0.366	1.000	1.000
310	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(6), AMY2B(7), ENPP1(8), ENPP3(6), G6PC(3), GANAB(5), GBA3(11), GBE1(2), GCK(5), GPI(5), GUSB(2), GYS1(1), GYS2(4), HK1(2), HK2(5), HK3(5), MGAM(5), PGM1(1), PYGB(4), PYGL(3), PYGM(6), SI(46), UCHL3(1), UGDH(2), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(4), UGT1A9(3), UGT2B15(3), UGT2B4(8), UXS1(4)	15136397	178	97	178	39	38	72	12	35	21	0	0.0198	1.000	1.000
311	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(3), BRAF(8), CHUK(2), CREB1(1), DAXX(3), FOS(2), HRAS(5), IKBKB(2), JUN(3), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP2K5(1), MAP2K6(2), MAP2K7(1), MAP3K1(3), MAP3K11(2), MAP3K12(4), MAP3K13(5), MAP3K14(1), MAP3K3(1), MAP3K4(4), MAP3K5(4), MAP3K6(1), MAP3K7(2), MAP3K9(4), MAP4K1(3), MAP4K2(1), MAP4K3(7), MAP4K4(6), MAP4K5(1), MAPK1(1), MAPK10(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPK4(2), MAPK6(4), MAPK7(1), MAPK8(3), MAPK9(1), MAPKAPK2(2), MAPKAPK3(1), MAPKAPK5(3), MEF2A(3), MEF2C(4), MEF2D(3), MKNK2(1), MYC(1), NFKB1(2), PAK1(2), PAK2(1), RAC1(1), RAF1(1), RELA(3), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), RPS6KA4(2), RPS6KA5(4), RPS6KB1(1), RPS6KB2(1), SHC1(2), SP1(2), STAT1(2), TGFB1(1), TGFB2(3), TRADD(1)	25334500	165	96	162	68	53	62	8	22	20	0	0.969	1.000	1.000
312	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(9), ACSL1(2), ACSL3(2), ACSL4(2), ACSL6(2), ADIPOQ(2), ADIPOR2(4), AKT1(1), AKT3(3), CAMKK2(1), CD36(1), CHUK(2), CPT1A(5), CPT1B(3), CPT1C(3), CPT2(2), G6PC(3), G6PC2(3), IKBKB(2), IRS1(7), IRS2(2), IRS4(3), JAK1(2), JAK2(4), JAK3(7), LEPR(15), MAPK10(1), MAPK8(3), MAPK9(1), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), PCK1(3), PCK2(1), POMC(2), PPARA(1), PPARGC1A(5), PRKAA2(5), PRKAB2(1), PRKAG2(4), PRKAG3(3), PRKCQ(4), PTPN11(3), RELA(3), RXRA(2), RXRG(7), SLC2A1(1), SLC2A4(2), SOCS3(1), STAT3(2), STK11(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TYK2(8)	21924435	169	95	168	51	44	61	10	25	29	0	0.286	1.000	1.000
313	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(2), APOA2(1), CD36(1), CITED2(1), CPT1B(3), CREBBP(17), EHHADH(1), EP300(9), FABP1(1), HSD17B4(1), JUN(3), LPL(3), MAPK1(1), MAPK3(1), ME1(2), MRPL11(1), MYC(1), NCOA1(6), NCOR1(9), NCOR2(7), NR0B2(1), NR1H3(2), NRIP1(3), PIK3CA(29), PIK3R1(2), PPARA(1), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), PTGS2(1), RB1(12), RELA(3), RXRA(2), SP1(2), STAT5A(2), TNF(1)	16730642	148	94	133	46	50	44	5	28	21	0	0.617	1.000	1.000
314	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(1), AKT3(3), BRAF(8), CAB39(1), DDIT4(2), EIF4B(5), FIGF(2), HIF1A(1), IGF1(3), MAPK1(1), MAPK3(1), PDPK1(1), PIK3CA(29), PIK3CB(4), PIK3CD(4), PIK3CG(19), PIK3R1(2), PIK3R2(4), PIK3R3(2), PIK3R5(2), PRKAA2(5), RHEB(1), RICTOR(3), RPS6(1), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), RPS6KA6(5), RPS6KB1(1), RPS6KB2(1), STK11(3), TSC1(5), TSC2(5), ULK1(4), ULK2(5), VEGFC(6)	14063036	150	93	136	32	55	44	11	18	22	0	0.0449	1.000	1.000
315	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(8), CPEB1(1), EGFR(7), ERBB2(2), ERBB4(13), ETS1(2), ETV6(4), FMN2(29), KRAS(2), MAP2K1(2), MAPK1(1), MAPK3(1), NOTCH1(18), NOTCH2(10), NOTCH3(7), NOTCH4(4), PIWIL1(8), PIWIL2(4), PIWIL3(4), RAF1(1), SOS1(11), SOS2(7), SPIRE1(2), SPIRE2(6)	13750291	154	93	152	47	36	57	7	29	24	1	0.569	1.000	1.000
316	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(3), CRKL(1), DOCK1(4), FOS(2), GAB1(3), HGF(10), HRAS(5), ITGA1(4), ITGB1(5), JUN(3), MAP2K1(2), MAP2K2(1), MAP4K1(3), MAPK1(1), MAPK3(1), MAPK8(3), MET(4), PAK1(2), PIK3CA(29), PIK3R1(2), PTEN(16), PTK2(6), PTPN11(3), PXN(3), RAF1(1), RAP1A(1), RAP1B(1), RASA1(8), SOS1(11), STAT3(2)	11740469	140	93	124	38	54	32	4	25	25	0	0.486	1.000	1.000
317	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(1), APC(9), AR(6), BRAF(8), CCL16(1), DAG1(2), EGFR(7), GNA11(1), GNA15(1), GNAI1(3), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(14), ITPR3(4), KCNJ3(11), KCNJ5(2), KCNJ9(3), MAPK1(1), MAPK10(1), MAPK14(1), PHKA2(4), PIK3CA(29), PIK3CD(4), PIK3R1(2), PITX2(3), PTX3(2), RAF1(1)	14155785	134	93	119	27	48	44	6	25	11	0	0.0136	1.000	1.000
318	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), AGPAT3(1), AGPAT4(1), AGPAT6(1), AKR1B1(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), CEL(1), DAK(1), DGAT1(1), DGAT2(3), DGKA(3), DGKB(6), DGKD(6), DGKE(4), DGKG(3), DGKI(13), DGKQ(1), DGKZ(4), GK(4), GK2(6), GLA(2), GPAM(3), LCT(18), LIPA(2), LIPC(2), LIPF(1), LIPG(3), LPL(3), MGLL(1), PNLIP(11), PNLIPRP1(4), PNLIPRP2(4), PNPLA3(1), PPAP2B(1)	15560990	135	91	135	55	37	59	3	26	10	0	0.881	1.000	1.000
319	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(2), INPP1(1), INPP4A(5), INPP4B(6), INPP5A(4), INPPL1(4), ITPKA(1), ITPKB(6), MIOX(1), OCRL(8), PIK3C2A(7), PIK3C2B(7), PIK3C2G(8), PIK3CA(29), PIK3CB(4), PIK3CG(19), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), PLCD1(1), PLCG1(3), PLCG2(5)	11951420	145	91	132	37	51	47	8	21	18	0	0.132	1.000	1.000
320	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(3), AGT(1), AKT1(1), CALM2(1), CALR(1), CAMK1G(3), CAMK4(3), CREBBP(17), CSNK1A1(2), ELSPBP1(1), FGF2(2), HAND1(1), HAND2(2), HRAS(5), IGF1(3), MAP2K1(2), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(3), MEF2C(4), MYH2(33), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NKX2-5(2), PIK3CA(29), PIK3R1(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), RAF1(1), RPS6KB1(1), SYT1(4)	13373979	166	91	152	48	56	60	9	27	14	0	0.361	1.000	1.000
321	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(2), CAD(11), CANT1(1), CDA(1), CTPS(3), CTPS2(2), DCK(1), DCTD(1), DPYD(9), DPYS(6), DTYMK(1), ENTPD1(1), ENTPD3(1), ENTPD5(1), ENTPD6(4), ENTPD8(1), NME4(1), NME7(3), NT5C1A(2), NT5C1B(2), NT5C2(3), NT5C3(3), NT5E(2), PNPT1(2), POLA1(7), POLD1(2), POLD2(1), POLD3(1), POLE(7), POLE2(2), POLE4(1), POLR1A(3), POLR1B(2), POLR1D(1), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(2), POLR3A(1), POLR3B(2), POLR3G(1), POLR3H(2), PRIM1(3), PRIM2(16), RFC5(1), RRM1(1), RRM2(1), RRM2B(3), TXNRD1(2), TXNRD2(3), UMPS(2), UPP1(3), UPP2(1), UPRT(1)	21538795	145	89	143	61	39	51	8	20	27	0	0.982	1.000	1.000
322	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(1), AKT3(3), BCR(2), BLNK(1), BTK(7), CD19(2), DAG1(2), EPHB2(6), ITPKA(1), ITPKB(6), LYN(2), MAP2K1(2), MAP2K2(1), MAPK1(1), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NFKBIL2(5), PI3(1), PIK3CA(29), PIK3CD(4), PIK3R1(2), PLCG2(5), PPP1R13B(5), RAF1(1), SERPINA4(7), SHC1(2), SOS1(11), SOS2(7), SYK(1), VAV1(7)	13969273	135	88	122	42	49	41	7	24	14	0	0.520	1.000	1.000
323	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(1), ACADL(2), ACADM(1), ACOX1(2), ACOX2(1), ACOX3(5), ACSL1(2), ACSL3(2), ACSL4(2), ACSL6(2), ADIPOQ(2), ANGPTL4(1), APOA2(1), APOA5(3), APOC3(2), AQP7(1), CD36(1), CPT1A(5), CPT1B(3), CPT1C(3), CPT2(2), CYP27A1(1), CYP4A22(2), CYP7A1(6), CYP8B1(1), DBI(2), EHHADH(1), FABP1(1), FABP5(1), FABP6(1), FABP7(1), FADS2(1), GK(4), GK2(6), HMGCS2(3), ILK(2), LPL(3), ME1(2), MMP1(3), NR1H3(2), PCK1(3), PCK2(1), PDPK1(1), PLTP(2), PPARA(1), PPARD(2), RXRA(2), RXRG(7), SCD(2), SCP2(1), SLC27A1(1), SLC27A2(5), SLC27A4(2), SLC27A5(4), SLC27A6(5), SORBS1(5), UBC(1), UCP1(2)	17311035	134	86	134	55	26	53	10	29	16	0	0.928	1.000	1.000
324	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(4), ADC(1), ALDH4A1(3), ALDH5A1(1), CAD(11), CPS1(30), EARS2(3), EPRS(12), GAD1(5), GAD2(6), GCLC(2), GCLM(1), GFPT1(1), GFPT2(4), GLS(4), GLS2(1), GLUD1(4), GLUD2(9), GLUL(4), GOT2(3), GPT(1), GPT2(4), GSR(4), GSS(2), NADSYN1(7), NAGK(2), PPAT(2)	10490270	131	85	130	31	30	60	6	24	11	0	0.0652	1.000	1.000
325	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP4(1), BMP5(8), BTRC(1), CSNK1A1(2), CSNK1A1L(5), CSNK1D(2), CSNK1G1(2), CSNK1G2(1), DHH(1), FBXW11(1), GLI1(3), GLI2(6), GLI3(9), HHIP(3), IHH(1), LRP2(41), PRKACB(3), PRKACG(1), PRKX(1), PTCH1(5), PTCH2(5), SHH(2), SMO(1), STK36(5), SUFU(2), WNT1(1), WNT10A(1), WNT10B(4), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT3A(2), WNT5A(1), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1), WNT8A(2), WNT9A(1), WNT9B(1), ZIC2(1)	15992445	142	85	141	61	33	52	16	25	16	0	0.947	1.000	1.000
326	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(1), AKT3(3), BRAF(8), DAG1(2), DRD2(4), EGFR(7), EPHB2(6), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(14), ITPR3(4), KCNJ3(11), KCNJ5(2), KCNJ9(3), MAPK1(1), PI3(1), PIK3CB(4), PITX2(3), PLCB1(8), PLCB2(5), PLCB3(4), PLCB4(7), RAF1(1), RGS20(1), SHC1(2), SOS1(11), SOS2(7), STAT3(2)	15553925	135	85	133	38	35	50	6	25	19	0	0.244	1.000	1.000
327	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(3), ACTB(1), ACTG1(2), ARHGEF2(7), CD14(2), CDC42(1), CDH1(3), CLDN1(2), CTNNB1(4), CTTN(5), FYN(5), HCLS1(3), ITGB1(5), KRT18(2), NCK1(2), NCK2(2), NCL(1), PRKCA(5), ROCK1(5), ROCK2(3), TLR4(10), TLR5(2), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(9), TUBA3D(2), TUBA3E(5), TUBA4A(1), TUBA8(1), TUBAL3(3), TUBB(1), TUBB1(1), TUBB2A(2), TUBB3(2), TUBB4(4), TUBB4Q(2), TUBB8(1), WAS(3), WASL(2), YWHAQ(1)	13917671	119	84	118	33	34	38	11	18	18	0	0.278	1.000	1.000
328	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(3), ACTB(1), ACTG1(2), ARHGEF2(7), CD14(2), CDC42(1), CDH1(3), CLDN1(2), CTNNB1(4), CTTN(5), FYN(5), HCLS1(3), ITGB1(5), KRT18(2), NCK1(2), NCK2(2), NCL(1), PRKCA(5), ROCK1(5), ROCK2(3), TLR4(10), TLR5(2), TUBA1A(1), TUBA1B(1), TUBA1C(2), TUBA3C(9), TUBA3D(2), TUBA3E(5), TUBA4A(1), TUBA8(1), TUBAL3(3), TUBB(1), TUBB1(1), TUBB2A(2), TUBB3(2), TUBB4(4), TUBB4Q(2), TUBB8(1), WAS(3), WASL(2), YWHAQ(1)	13917671	119	84	118	33	34	38	11	18	18	0	0.278	1.000	1.000
329	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(11), COL4A2(14), COL4A3(10), COL4A4(11), COL4A5(4), COL4A6(10), F10(3), F11(3), F12(1), F2R(2), F5(19), F8(10), F9(7), FGA(5), FGB(4), FGG(2), KLKB1(7), PROS1(5), SERPINC1(7), SERPING1(3)	11776850	138	84	138	32	33	61	7	21	16	0	0.253	1.000	1.000
330	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(2), APAF1(4), ARHGDIB(2), BAG4(1), BIRC2(1), BIRC3(3), CASP2(1), CASP7(2), CASP8(2), CASP9(3), CFLAR(2), CHUK(2), CRADD(1), DAXX(3), DFFB(2), FADD(1), GSN(2), LMNA(1), MAP2K7(1), MAP3K1(3), MAP3K14(1), MAP3K5(4), MAPK8(3), MDM2(2), NFKB1(2), NUMA1(5), PAK2(1), PRKCD(2), PRKDC(12), PSEN1(3), PSEN2(3), PTK2(6), RASA1(8), RB1(12), RELA(3), SPTAN1(4), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF1(4)	18474435	119	83	118	37	28	36	4	21	30	0	0.631	1.000	1.000
331	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(1), ABP1(5), ACAT1(2), ACMSD(1), AFMID(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), AOC2(2), AOC3(3), AOX1(13), ASMT(1), CARM1(1), CYP1A1(7), CYP1A2(1), CYP1B1(1), DDC(6), ECHS1(1), EHHADH(1), GCDH(2), HADH(1), HADHA(2), HSD17B4(1), INMT(3), KMO(3), KYNU(3), LCMT1(2), LCMT2(1), LNX1(2), METTL2B(1), METTL6(2), NFX1(2), OGDH(3), OGDHL(6), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), TDO2(2), TPH1(2), TPH2(6), WARS(4), WARS2(2), WBSCR22(3)	16031150	127	83	127	47	27	44	6	33	17	0	0.794	1.000	1.000
332	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(7), CALM2(1), FCER1A(4), FCER1G(1), FOS(2), HRAS(5), JUN(3), LYN(2), MAP2K1(2), MAP2K4(1), MAP2K7(1), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), PAK2(1), PIK3CA(29), PIK3R1(2), PLA2G4A(7), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), RAF1(1), SHC1(2), SOS1(11), SYK(1), SYT1(4), VAV1(7)	11363498	130	82	115	35	53	43	8	16	10	0	0.362	1.000	1.000
333	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), AKR1C2(1), AKR1C3(1), AKR1C4(1), ALDH3A1(2), ALDH3B2(1), CYP1A1(7), CYP1A2(1), CYP1B1(1), CYP2B6(4), CYP2C18(2), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2F1(3), CYP2S1(1), CYP3A4(1), CYP3A43(4), CYP3A7(1), GSTA1(3), GSTA2(2), GSTA4(1), GSTA5(2), GSTM3(1), GSTM4(3), GSTM5(3), GSTP1(1), GSTZ1(2), MGST1(2), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(4), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(4), UGT2B11(5), UGT2B15(3), UGT2B28(5), UGT2B4(8), UGT2B7(2)	14910265	129	82	129	39	31	45	11	32	10	0	0.443	1.000	1.000
334	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(3), CD3D(1), CTLA4(1), DAG1(2), DTYMK(1), EPHB2(6), FBXW7(11), GRAP2(1), ITK(2), ITPKA(1), ITPKB(6), LCK(3), LCP2(2), MAPK1(1), NCK1(2), NFAT5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NFKBIL2(5), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(6), PLCG1(3), PTPRC(7), RAF1(1), RASGRP1(1), RASGRP2(1), RASGRP3(8), RASGRP4(5), SOS1(11), SOS2(7), VAV1(7), ZAP70(5)	14847334	127	82	124	42	33	42	12	23	17	0	0.720	1.000	1.000
335	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(3), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3B2(1), ALDH7A1(1), ALDH9A1(2), ALDOA(1), ALDOB(2), BPGM(1), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(3), G6PC2(3), GAPDH(2), GAPDHS(1), GCK(5), GPI(5), HK1(2), HK2(5), HK3(5), LDHAL6A(2), LDHAL6B(1), LDHB(3), LDHC(3), PDHA1(3), PDHA2(8), PFKL(2), PFKM(6), PFKP(2), PGAM2(1), PGAM4(1), PGK1(2), PGK2(4), PGM1(1), PKLR(4), PKM2(3), TPI1(3)	15386973	113	81	113	49	30	43	8	19	13	0	0.928	1.000	1.000
336	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(1), BRAF(8), CREB1(1), CREB3(2), CREB5(3), CREBBP(17), CRKL(1), DAG1(2), EGR1(2), EGR2(6), EGR3(2), FRS2(4), JUN(3), MAP1B(4), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK3(1), MAPK8(3), MAPK8IP1(2), MAPK8IP3(4), MAPK9(1), NTRK1(4), OPN1LW(3), PIK3C2G(8), PIK3CA(29), PIK3CD(4), PIK3R1(2), PTPN11(3), RPS6KA3(1), SHC1(2), TH(2)	13630389	129	81	115	43	49	45	7	18	10	0	0.637	1.000	1.000
337	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(9), CCND1(1), CCND2(3), CCND3(1), CTNNB1(4), DVL1(3), DVL3(2), FOSL1(1), FZD1(1), FZD10(2), FZD2(1), FZD3(5), FZD6(3), FZD7(3), FZD8(1), FZD9(2), JUN(3), LDLR(4), MAPK10(1), MAPK9(1), MYC(1), PAFAH1B1(1), PLAU(2), PPP2R5C(6), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCI(5), PRKCQ(4), PRKCZ(1), PRKD1(11), RAC1(1), SFRP4(4), TCF7(1), WNT1(1), WNT10A(1), WNT10B(4), WNT11(1), WNT2(3), WNT2B(3), WNT3(2), WNT5A(1), WNT5B(1), WNT6(2), WNT7A(3), WNT7B(1)	15854150	130	81	129	40	40	56	8	18	8	0	0.336	1.000	1.000
338	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(5), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), ALDH3A1(2), ALDH3B2(1), AOC2(2), AOC3(3), AOX1(13), CARM1(1), DBH(2), DCT(4), DDC(6), ECH1(1), ESCO1(2), ESCO2(1), FAH(1), GOT2(3), GSTZ1(2), HGD(4), HPD(1), LCMT1(2), LCMT2(1), METTL2B(1), METTL6(2), MYST3(11), MYST4(4), PNMT(2), PNPLA3(1), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), SH3GLB1(1), TAT(1), TH(2), TPO(10), TYR(10), TYRP1(2), WBSCR22(3)	15738617	135	79	135	43	31	54	5	27	18	0	0.470	1.000	1.000
339	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	ABP1(5), ACAT1(2), ACMSD(1), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), AOC2(2), AOC3(3), AOX1(13), ASMT(1), CYP19A1(4), CYP1A1(7), CYP1A2(1), CYP2A13(1), CYP2A6(5), CYP2A7(1), CYP2B6(4), CYP2C18(2), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2D6(3), CYP2F1(3), CYP2J2(1), CYP3A4(1), CYP3A7(1), CYP4B1(3), CYP4F8(4), DDC(6), ECHS1(1), EHHADH(1), GCDH(2), HADHA(2), KMO(3), KYNU(3), SDS(2), TDO2(2), TPH1(2), WARS(4), WARS2(2)	14600619	124	79	124	52	36	41	6	32	9	0	0.924	1.000	1.000
340	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH7(1), ADHFE1(2), AGPAT3(1), AGPAT4(1), AKR1B1(1), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), CEL(1), DGAT1(1), DGKA(3), DGKB(6), DGKD(6), DGKE(4), DGKG(3), DGKQ(1), DGKZ(4), GK(4), GLA(2), LCT(18), LIPC(2), LIPF(1), LIPG(3), LPL(3), PNLIP(11), PNLIPRP1(4), PNLIPRP2(4), PPAP2B(1)	12775167	106	78	106	46	29	46	3	20	8	0	0.922	1.000	1.000
341	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(7), ATP4A(6), ATP4B(2), ATP5A1(3), ATP5B(2), ATP5C1(3), ATP5G2(2), ATP5G3(1), ATP5L(1), ATP6V0A1(4), ATP6V0A2(6), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), COX10(2), COX4I1(1), COX4I2(1), COX6B1(2), COX6C(1), COX7B2(3), CYC1(5), NDUFA10(3), NDUFA13(2), NDUFA7(1), NDUFA9(1), NDUFAB1(1), NDUFB1(1), NDUFB5(2), NDUFB6(1), NDUFB7(2), NDUFB8(2), NDUFB9(1), NDUFS1(4), NDUFS6(1), NDUFS8(1), NDUFV1(2), NDUFV2(2), PPA2(1), SDHA(3), SDHB(2), UQCRB(1), UQCRC2(1), UQCRFS1(2)	14780080	112	78	112	33	28	30	13	26	15	0	0.452	1.000	1.000
342	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	64	ACHE(3), AGPAT3(1), AGPAT4(1), AGPAT6(1), CDS1(2), CHAT(9), CHKA(4), CHPT1(1), CRLS1(2), DGKA(3), DGKB(6), DGKD(6), DGKE(4), DGKG(3), DGKI(13), DGKQ(1), DGKZ(4), ESCO1(2), ESCO2(1), ETNK1(3), GNPAT(2), GPAM(3), GPD1(2), GPD1L(1), GPD2(2), LYPLA1(3), MYST3(11), MYST4(4), PCYT1B(2), PISD(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLD1(7), PLD2(2), PNPLA3(1), PPAP2B(1), PTDSS1(4), SH3GLB1(1)	17375860	139	78	139	55	36	55	9	22	17	0	0.907	1.000	1.000
343	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	CREBBP(17), CTBP1(2), DLL1(1), DLL3(1), DLL4(1), DTX2(3), DTX3(2), DTX3L(3), DTX4(2), DVL1(3), DVL3(2), EP300(9), HDAC1(2), JAG1(1), JAG2(2), LFNG(1), MAML1(3), MAML2(7), MFNG(1), NCOR2(7), NCSTN(3), NOTCH1(18), NOTCH2(10), NOTCH3(7), NOTCH4(4), PSEN1(3), PSEN2(3), PSENEN(1), SNW1(2)	18305930	121	78	120	49	18	45	11	26	21	0	0.954	1.000	1.000
344	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(28), B3GALT4(1), CDR1(4), DGKI(13), IL6ST(1), MRPL19(1), PIGK(1), RPL13(1), RPL14(1), RPL19(1), RPL28(1), RPL32(1), RPL37(1), RPL3L(2), RPL4(1), RPL5(2), RPL7(1), RPL7A(1), RPL8(2), RPLP0(3), RPS11(1), RPS12(1), RPS18(1), RPS19(1), RPS2(1), RPS20(1), RPS21(1), RPS26(1), RPS6(1), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), RPS6KA6(5), RPS6KB1(1), RPS6KB2(1), RPS8(2), SLC36A2(2), TBC1D10C(3), TSPAN9(1), UBB(2), UBC(1)	13868005	104	78	104	42	29	34	7	26	8	0	0.921	1.000	1.000
345	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	AKT1(1), DAG1(2), DGKA(3), ETFA(3), GCA(2), ITGA9(2), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(14), ITPR3(4), MAP2K1(2), MAPK1(1), MAPK3(1), NR1I3(1), PAK1(2), PDE3A(8), PDE3B(5), PI3(1), PIK3C2G(8), PIK3CA(29), PIK3CD(4), PIK3R1(2), RIPK3(1), SGCB(3), VASP(2)	12969096	114	78	100	35	44	38	4	16	11	1	0.379	1.000	1.000
346	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(5), AGMAT(1), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH4A1(3), ALDH9A1(2), AMD1(1), AOC2(2), AOC3(3), ARG1(2), ASL(4), CKM(2), CKMT2(3), CPS1(30), DAO(2), GATM(1), GLUD1(4), GOT2(3), NOS1(11), NOS3(2), OAT(1), ODC1(1), OTC(3), P4HA1(2), P4HA2(3), P4HA3(3), P4HB(5), PYCR1(1), RARS(4), SMS(2)	11693515	116	77	115	32	22	49	4	24	17	0	0.184	1.000	1.000
347	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(3), F11(3), F12(1), F13B(13), F5(19), F7(2), F8(10), F9(7), FGA(5), FGB(4), FGG(2), LPA(15), PLAT(1), PLAU(2), PLG(2), SERPINB2(4), SERPINF2(3), VWF(17)	9325627	113	76	113	25	35	41	8	18	11	0	0.0943	1.000	1.000
348	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(6), ADCY4(4), ADCY6(2), ADCY8(18), CACNA1A(11), CACNA1B(10), GNAS(6), GNAT3(1), GNB1(1), GNB3(2), GRM4(3), ITPR3(4), KCNB1(1), PDE1A(2), PLCB2(5), PRKACB(3), PRKACG(1), PRKX(1), SCNN1A(1), SCNN1B(1), SCNN1G(3), TAS1R1(3), TAS1R3(3), TAS2R1(4), TAS2R10(3), TAS2R16(4), TAS2R3(2), TAS2R38(2), TAS2R39(2), TAS2R4(1), TAS2R40(3), TAS2R41(5), TAS2R42(2), TAS2R5(1), TAS2R60(8), TAS2R7(1), TAS2R8(1), TAS2R9(3), TRPM5(1)	15086884	135	76	135	54	37	45	8	34	11	0	0.816	1.000	1.000
349	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(2), ACTG2(6), AKT1(1), CDC42(1), CFL1(2), CFL2(1), FLNA(14), FLNC(16), FSCN2(1), FSCN3(2), GDI1(2), GDI2(2), MYH2(33), MYLK(8), MYLK2(4), PAK1(2), PAK2(1), PAK3(1), PAK4(1), PAK6(1), PAK7(6), PFN2(1), RHO(1), ROCK1(5), ROCK2(3), VASP(2), WASF1(1), WASL(2)	12714411	122	76	122	45	29	54	7	19	13	0	0.727	1.000	1.000
350	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(4), ATP6V0A1(4), ATP6V0A2(6), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), CDC42(1), CHUK(2), EGFR(7), F11R(1), GIT1(1), HBEGF(1), IGSF5(2), IKBKB(2), JAM2(2), JUN(3), LYN(2), MAP2K4(1), MAP3K14(1), MAPK10(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK8(3), MAPK9(1), MET(4), NFKB1(2), NFKB2(2), NOD1(4), PAK1(2), PLCG1(3), PLCG2(5), PTPN11(3), PTPRZ1(9), RAC1(1), RELA(3), TJP1(9)	18621548	120	75	118	33	31	36	7	23	23	0	0.314	1.000	1.000
351	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(2), AARS2(5), CARS(8), CARS2(1), DARS(1), DARS2(5), EARS2(3), EPRS(12), FARS2(2), FARSA(5), HARS(2), HARS2(2), IARS(3), IARS2(3), KARS(3), LARS(1), LARS2(3), MARS(1), NARS(4), NARS2(2), PARS2(4), RARS(4), RARS2(2), SARS(2), SARS2(3), TARS(3), TARS2(4), VARS(5), VARS2(2), WARS(4), WARS2(2), YARS(1), YARS2(2)	14365230	106	74	106	28	40	33	5	16	12	0	0.237	1.000	1.000
352	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(1), AKT1(1), APC(9), CAV3(1), DAG1(2), DLG4(1), EPHB2(6), GNAI1(3), ITPR1(6), ITPR2(14), ITPR3(4), KCNJ3(11), KCNJ5(2), KCNJ9(3), MAPK1(1), PITX2(3), PTX3(2), RAC1(1), RHO(1), RYR1(28)	12203509	100	74	99	28	22	38	6	20	14	0	0.190	1.000	1.000
353	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(4), ALDH4A1(3), ALDH5A1(1), CAD(11), CPS1(30), EPRS(12), GAD1(5), GAD2(6), GCLC(2), GCLM(1), GFPT1(1), GLS(4), GLS2(1), GLUD1(4), GLUL(4), GOT2(3), GPT(1), GPT2(4), GSS(2), NADSYN1(7), PPAT(2)	8821524	108	73	107	25	22	50	5	23	8	0	0.0918	1.000	1.000
354	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH7(1), ADHFE1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3B2(1), ALDH9A1(2), ALDOA(1), ALDOB(2), BPGM(1), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(3), GAPDH(2), GCK(5), GPI(5), HK1(2), HK2(5), HK3(5), LDHB(3), LDHC(3), PDHA1(3), PDHA2(8), PFKM(6), PFKP(2), PGK1(2), PGM1(1), PKLR(4), PKM2(3), TPI1(3)	12914807	97	72	97	36	26	40	5	17	9	0	0.686	1.000	1.000
355	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH7(1), ADHFE1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3B2(1), ALDH9A1(2), ALDOA(1), ALDOB(2), BPGM(1), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(3), GAPDH(2), GCK(5), GPI(5), HK1(2), HK2(5), HK3(5), LDHB(3), LDHC(3), PDHA1(3), PDHA2(8), PFKM(6), PFKP(2), PGK1(2), PGM1(1), PKLR(4), PKM2(3), TPI1(3)	12914807	97	72	97	36	26	40	5	17	9	0	0.686	1.000	1.000
356	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(3), AGPAT3(1), AGPAT4(1), AGPS(1), CDS1(2), CHAT(9), CHKA(4), CPT1B(3), DGKA(3), DGKB(6), DGKD(6), DGKE(4), DGKG(3), DGKQ(1), DGKZ(4), ETNK1(3), GNPAT(2), GPD1(2), GPD2(2), LGALS13(1), LYPLA1(3), PAFAH1B1(1), PCYT1B(2), PISD(1), PLA2G2A(1), PLA2G2E(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLCB2(5), PLCG1(3), PLCG2(5), PPAP2B(1)	13242836	102	71	102	37	29	40	9	15	9	0	0.677	1.000	1.000
357	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(1), AASDHPPT(1), AASS(11), ACAT1(2), AKR1B10(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), BBOX1(2), DLST(1), DOT1L(5), ECHS1(1), EHHADH(1), EHMT1(5), EHMT2(1), GCDH(2), HADH(1), HADHA(2), HSD17B4(1), NSD1(10), OGDH(3), OGDHL(6), PIPOX(1), PLOD1(4), PLOD2(5), PLOD3(5), RDH11(1), RDH12(2), RDH13(1), SETD1A(8), SETDB1(3), SPCS1(1), SPCS3(2), SUV39H1(2), SUV39H2(2), TMLHE(1)	15332602	105	71	105	43	20	36	7	24	18	0	0.921	1.000	1.000
358	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(2), CALR(1), CANX(2), CD4(1), CD8A(2), CD8B(1), CIITA(3), CREB1(1), CTSL1(3), CTSS(2), HLA-A(7), HLA-B(1), HLA-C(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(1), HLA-DOB(1), HLA-DPA1(2), HLA-DQA2(1), HLA-DRA(1), HLA-DRB1(2), HLA-DRB5(2), HLA-G(2), HSP90AA1(3), HSP90AB1(3), HSPA5(4), IFNA1(1), IFNA10(3), IFNA14(2), IFNA16(2), IFNA17(1), IFNA4(1), IFNA6(1), IFNA7(1), IFNA8(2), KIR2DL1(2), KIR2DL3(4), KIR2DL4(1), KIR2DS4(5), KIR3DL1(6), KIR3DL2(1), KIR3DL3(1), KLRC1(1), KLRC3(2), KLRD1(1), LTA(2), NFYA(1), NFYB(1), PDIA3(2), PSME2(1), TAP1(3), TAP2(1), TAPBP(4)	12292651	104	70	102	44	30	30	8	19	16	1	0.915	1.000	1.000
359	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(2), AARS2(5), ABAT(4), ACY3(2), ADSL(1), ADSS(1), ADSSL1(2), AGXT(2), AGXT2(2), ASL(4), ASNS(5), CAD(11), DARS(1), DARS2(5), DDO(2), DLAT(1), DLD(2), GAD1(5), GAD2(6), GOT2(3), GPT(1), GPT2(4), NARS(4), NARS2(2), PC(2), PDHA1(3), PDHA2(8)	10035740	90	69	90	31	25	30	5	19	11	0	0.629	1.000	1.000
360	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), CDK5(1), CDK5R1(1), CFL1(2), CHN1(2), MAP3K1(3), MYL2(2), MYLK(8), NCF2(3), PAK1(2), PDGFRA(10), PIK3CA(29), PIK3R1(2), PLD1(7), PPP1R12B(5), RAC1(1), RALBP1(1), RPS6KB1(1), TRIO(8), VAV1(7), WASF1(1)	9281494	97	69	84	24	45	28	4	17	3	0	0.200	1.000	1.000
361	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(1), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(3), EIF2S2(1), ELAVL1(1), FLT1(11), FLT4(5), HIF1A(1), HRAS(5), KDR(16), NOS3(2), PIK3CA(29), PIK3R1(2), PLCG1(3), PRKCA(5), PTK2(6), PXN(3), SHC1(2), VHL(1)	8990925	102	69	88	29	43	30	4	15	10	0	0.371	1.000	1.000
362	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(2), DIAPH1(1), FYN(5), GSN(2), HRAS(5), ITGA1(4), ITGB1(5), MAP2K1(2), MAPK1(1), MAPK3(1), MYL2(2), MYLK(8), PIK3CA(29), PIK3R1(2), PTK2(6), PXN(3), RAF1(1), ROCK1(5), SHC1(2), TLN1(6)	9907655	92	68	78	20	41	25	6	17	3	0	0.141	1.000	1.000
363	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(9), CALCR(10), CALCRL(4), CRHR1(4), CRHR2(3), ELTD1(18), EMR1(11), EMR2(4), GHRHR(4), GLP1R(1), GLP2R(5), GPR64(5), LPHN1(3), LPHN2(7), LPHN3(17), SCTR(1), VIPR2(3)	7056676	109	68	109	30	33	33	9	22	12	0	0.165	1.000	1.000
364	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(1), AKT3(3), GSK3A(3), IL4R(2), IRS1(7), IRS2(2), JAK1(2), JAK3(7), MAP4K1(3), MAPK1(1), MAPK3(1), PDK1(1), PIK3CA(29), PIK3CD(4), PIK3R1(2), PPP1R13B(5), RAF1(1), SHC1(2), SOS1(11), SOS2(7), STAT6(2)	9665063	96	68	83	28	36	28	2	20	10	0	0.422	1.000	1.000
365	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(6), CXCR4(5), GNAI1(3), GNB1(1), HRAS(5), MAP2K1(2), MAPK1(1), MAPK3(1), NFKB1(2), PIK3C2G(8), PIK3CA(29), PIK3R1(2), PLCG1(3), PRKCA(5), PTK2(6), PXN(3), RAF1(1), RELA(3)	7359297	86	67	72	23	37	24	5	17	3	0	0.289	1.000	1.000
366	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(10), AKT1(1), GNAI1(3), GNB1(1), ITGAV(4), ITGB3(4), MAPK1(1), MAPK3(1), PDGFRA(10), PIK3CA(29), PIK3R1(2), PLCB1(8), PRKCA(5), PTK2(6), RAC1(1), SMPD1(4), SMPD2(1)	7268583	91	67	78	22	41	24	5	20	1	0	0.169	1.000	1.000
367	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B3GNT6(1), B4GALT5(2), C1GALT1C1(1), GALNT1(2), GALNT10(3), GALNT11(2), GALNT12(3), GALNT13(14), GALNT14(4), GALNT2(2), GALNT3(3), GALNT5(7), GALNT6(2), GALNT8(3), GALNT9(1), GALNTL1(4), GALNTL4(4), GALNTL5(3), GCNT1(3), GCNT3(2), OGT(2), ST3GAL1(4), ST6GALNAC1(3), WBSCR17(12)	8546433	87	67	85	29	20	34	10	14	9	0	0.664	1.000	1.000
368	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(1), ALDOB(2), DLAT(1), DLD(2), ENO2(1), ENO3(1), FBP2(1), G6PC(3), GAPDH(2), GAPDHS(1), GCK(5), GOT2(3), GPI(5), HK1(2), HK2(5), HK3(5), LDHAL6B(1), LDHB(3), LDHC(3), MDH1(1), MDH2(1), PC(2), PCK1(3), PDHA1(3), PDHA2(8), PDHX(1), PFKL(2), PFKM(6), PFKP(2), PGAM2(1), PGK1(2), PGK2(4), PKLR(4), PKM2(3), TPI1(3)	11216771	93	66	93	42	24	35	5	18	11	0	0.924	1.000	1.000
369	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(1), APC(9), CCND1(1), CD14(2), CTNNB1(4), DVL1(3), FZD1(1), GJA1(4), GNAI1(3), IRAK1(4), LBP(4), LEF1(3), NFKB1(2), PDPK1(1), PIK3CA(29), PIK3R1(2), RELA(3), TLR4(10), TOLLIP(1), WNT1(1)	8114514	88	66	75	21	37	19	10	14	8	0	0.273	1.000	1.000
370	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	BLVRA(2), COX10(2), CP(2), CPOX(2), EARS2(3), EPRS(12), FECH(2), FTH1(2), FTMT(7), GUSB(2), HCCS(1), MMAB(1), PPOX(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(4), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(4), UGT2B11(5), UGT2B15(3), UGT2B28(5), UGT2B4(8), UGT2B7(2), UROD(1), UROS(1)	10906565	95	66	95	25	26	34	9	18	8	0	0.303	1.000	1.000
371	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	CHUK(2), DAXX(3), EGF(6), EGFR(7), ETS1(2), FOS(2), HOXA7(2), HRAS(5), IKBKB(2), JUN(3), MAP2K1(2), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP2K7(1), MAP3K1(3), MAP3K14(1), MAP3K5(4), MAPK1(1), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(3), NFKB1(2), PRKCA(5), PRKCD(2), PRKCE(3), PRKCG(9), PRKCQ(4), RAF1(1), RELA(3), SP1(2), TNF(1), TNFRSF1A(2), TNFRSF1B(1)	13005875	94	66	91	29	28	37	6	13	10	0	0.450	1.000	1.000
372	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(11), GABBR1(5), GPRC5A(1), GPRC5C(4), GRM1(13), GRM2(3), GRM3(14), GRM4(3), GRM5(12), GRM7(10), GRM8(14)	5532457	90	65	90	38	17	36	15	14	8	0	0.809	1.000	1.000
373	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(1), AKT3(3), ARHGEF11(8), CDC42(1), DLG4(1), GNA13(1), LPA(15), MAP2K4(1), MAP3K1(3), MAP3K5(4), MAPK8(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NFKBIL2(5), PDK1(1), PHKA2(4), PI3(1), PIK3CB(4), PLD1(7), PLD2(2), PLD3(1), PTK2(6), RDX(2), ROCK1(5), ROCK2(3), SERPINA4(7), SRF(2), TBXA2R(2)	13006015	101	65	100	38	25	37	4	25	10	0	0.867	1.000	1.000
374	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSA(2), ARSD(1), ARSE(2), B4GALT6(2), CERK(6), DEGS1(1), ENPP7(5), GAL3ST1(1), GALC(2), GBA(4), GLA(2), LCT(18), NEU1(3), NEU2(2), NEU4(2), PPAP2B(1), SGMS1(3), SGMS2(1), SGPP1(2), SMPD1(4), SMPD2(1), SMPD3(3), SMPD4(8), SPHK2(1), SPTLC1(1), SPTLC2(3), UGCG(1), UGT8(7)	9449717	89	64	89	28	18	32	7	22	10	0	0.391	1.000	1.000
375	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(2), ADRA1B(3), ADRA1D(3), ADRA2C(2), ADRB1(1), ADRB2(4), CHRM2(9), CHRM3(5), CHRM4(1), CHRM5(3), DRD1(1), DRD2(4), DRD3(5), DRD4(1), DRD5(5), HRH1(3), HRH2(2), HTR1A(8), HTR1B(3), HTR1E(5), HTR1F(3), HTR2A(3), HTR2B(1), HTR2C(5), HTR4(3), HTR5A(4), HTR6(2), HTR7(4)	6774899	95	64	95	40	22	40	7	18	8	0	0.535	1.000	1.000
376	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(4), AR(6), ESR1(6), ESR2(2), HNF4A(2), NR0B1(4), NR1D2(1), NR1H2(1), NR1H3(2), NR1I2(1), NR1I3(1), NR2C2(3), NR2E1(4), NR2F6(1), NR3C1(1), NR4A1(4), NR4A2(4), NR5A2(5), PGR(4), PPARA(1), PPARD(2), RARA(1), RARB(3), RARG(1), ROR1(3), RORA(2), RORC(2), RXRA(2), RXRG(7), THRA(1), THRB(2), VDR(4)	11103406	87	64	87	34	21	35	2	16	13	0	0.767	1.000	1.000
377	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	GORASP1(1), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPK3(1), MAPK8(3), MAPK8IP1(2), MAPK8IP3(4), MAPK9(1), MAPKAPK5(3), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NFKBIL2(5), PIK3CA(29), PIK3CD(4), PIK3R1(2), SYT1(4), TRAF3(3), TRAF5(2), TRAF6(5)	8881361	86	64	73	17	38	27	2	12	7	0	0.0278	1.000	1.000
378	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(4), BAX(1), BCL2A1(2), BCL2L1(1), CASP1(1), CASP10(3), CASP2(1), CASP4(4), CASP7(2), CASP8(2), CASP9(3), CD40(2), CD40LG(3), CRADD(1), DAXX(3), DFFB(2), FADD(1), FAS(1), FASLG(1), IKBKE(3), LTA(2), MCL1(2), NFKB1(2), NGFR(1), NR3C1(1), NTRK1(4), PTPN13(9), SFRS2IP(4), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF1(4), TRAF3(3), TRAF6(5)	11604373	83	63	82	37	26	16	5	18	18	0	0.986	1.000	1.000
379	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(1), AGTR1(5), ATF2(3), CALM2(1), EGFR(7), HRAS(5), JUN(3), MAP2K1(2), MAP2K2(1), MAP2K4(1), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8(3), MEF2A(3), MEF2C(4), MEF2D(3), PAK1(2), PRKCA(5), PTK2(6), RAC1(1), RAF1(1), SHC1(2), SOS1(11), SYT1(4)	8876494	79	63	76	22	22	30	5	17	5	0	0.409	1.000	1.000
380	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(1), AGTR2(3), CALM2(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CDK5(1), FYN(5), GNA11(1), GNAI1(3), GNB1(1), HRAS(5), JAK2(4), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(3), MAPT(4), MYLK(8), PLCG1(3), PRKCA(5), RAF1(1), SHC1(2), SOS1(11), STAT1(2), STAT3(2), STAT5A(2), SYT1(4)	11027890	82	63	81	22	20	28	10	16	8	0	0.367	1.000	1.000
381	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(1), CABIN1(5), CALM2(1), CAMK1G(3), HDAC5(1), IGF1(3), IGF1R(1), INSR(10), MAP2K6(2), MAPK14(1), MAPK7(1), MEF2A(3), MEF2C(4), MEF2D(3), MYOD1(1), NFATC1(3), NFATC2(4), PIK3CA(29), PIK3R1(2), PPP3CA(4), PPP3CB(4), PPP3CC(2), SYT1(4)	9194816	92	63	79	27	42	27	3	13	7	0	0.306	1.000	1.000
382	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(3), ACTN1(2), ACTN2(10), ACTN3(2), BCAR1(6), BCR(2), CAPN1(2), CAPNS2(1), CRKL(1), FYN(5), HRAS(5), ITGA1(4), ITGB1(5), JUN(3), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(3), PPP1R12B(5), PTK2(6), PXN(3), RAF1(1), RAP1A(1), ROCK1(5), SHC1(2), SOS1(11), TLN1(6), VCL(2), ZYX(1)	12459260	102	63	100	32	29	36	5	23	9	0	0.539	1.000	1.000
383	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(11), CANT1(1), CDA(1), CTPS(3), CTPS2(2), DCK(1), DCTD(1), DPYD(9), DPYS(6), DTYMK(1), ENTPD1(1), NT5E(2), POLB(1), POLD1(2), POLD2(1), POLE(7), POLG(2), POLL(2), POLQ(19), POLR1B(2), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(2), POLRMT(2), RRM1(1), RRM2(1), TXNRD1(2), UMPS(2), UPP1(3)	15194434	97	63	97	25	27	39	3	15	13	0	0.205	1.000	1.000
384	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(1), BTK(7), CALM2(1), CD79A(1), FOS(2), HRAS(5), JUN(3), LYN(2), MAP2K1(2), MAP3K1(3), MAPK14(1), MAPK3(1), MAPK8(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(5), RAC1(1), RAF1(1), SHC1(2), SOS1(11), SYK(1), SYT1(4), VAV1(7)	10091050	92	62	90	24	29	35	8	11	9	0	0.313	1.000	1.000
385	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(12), CARM1(1), CCND1(1), CREBBP(17), EP300(9), ERCC3(1), ESR1(6), GRIP1(6), GTF2A1(1), GTF2E1(2), GTF2F1(1), HDAC1(2), HDAC3(1), HDAC4(5), HDAC5(1), MEF2C(4), NCOR2(7), NR0B1(4), NRIP1(3), PELP1(1), POLR2A(2), TBP(1)	12164786	88	62	87	32	19	34	4	20	11	0	0.807	1.000	1.000
386	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(5), ACY3(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3B2(1), ALDH7A1(1), ALDH9A1(2), AMDHD1(1), AOC2(2), AOC3(3), CARM1(1), CNDP1(3), DDC(6), FTCD(3), HAL(2), HARS(2), HARS2(2), HDC(6), HNMT(3), LCMT1(2), LCMT2(1), METTL2B(1), METTL6(2), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), PRPS1(2), PRPS2(1), UROC1(3), WBSCR22(3)	10476733	84	62	84	37	13	38	6	16	11	0	0.885	1.000	1.000
387	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(1), GTF2B(2), GTF2E1(2), GTF2F1(1), GTF2H1(2), GTF2H3(1), GTF2H4(2), GTF2I(2), GTF2IRD1(6), TAF1(15), TAF1L(21), TAF2(10), TAF4(3), TAF4B(4), TAF5(1), TAF5L(2), TAF6L(2), TAF7L(2), TAF9(2), TBPL2(1)	9561342	82	62	82	20	21	30	9	12	10	0	0.320	1.000	1.000
388	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(2), ACTG2(6), ADCY3(7), ADCY9(3), ARF1(1), ARF5(4), ATP6V0A1(4), ATP6V0A2(6), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(2), ATP6V1A(4), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ERO1L(1), GNAS(6), PDIA4(4), PLCG1(3), PLCG2(5), PRKCA(5), SEC61A1(2), SEC61A2(1), SEC61G(2), TRIM23(3)	9798214	84	62	84	24	23	31	7	15	8	0	0.357	1.000	1.000
389	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(6), CDC7(3), DIAPH2(4), GMNN(2), MCM10(4), MCM2(1), MCM3(1), MCM4(5), MCM5(6), MCM6(3), MCM7(3), ORC1L(3), ORC2L(1), ORC3L(2), ORC5L(3), POLD1(2), POLD2(1), POLD3(1), POLE(7), POLE2(2), PRIM1(3), RFC1(1), RFC4(5), RFC5(1), RPA1(1), RPA2(1), RPA4(2), UBB(2), UBC(1)	13479647	77	61	77	28	26	19	1	19	12	0	0.802	1.000	1.000
390	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(1), AKR1B10(2), B4GALT1(1), G6PC(3), G6PC2(3), GALK2(1), GALT(1), GANC(4), GCK(5), GLA(2), HK1(2), HK2(5), HK3(5), LCT(18), MGAM(5), PFKL(2), PFKM(6), PFKP(2), PGM1(1), RDH11(1), RDH12(2), RDH13(1), UGP2(4)	10247970	77	61	77	30	20	25	4	18	10	0	0.721	1.000	1.000
391	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM2(1), DLG4(1), GRIN1(1), GRIN2A(16), GRIN2B(18), GRIN2C(3), GRIN2D(4), NOS1(11), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), SYT1(4)	6750568	85	61	84	31	23	31	7	13	11	0	0.675	1.000	1.000
392	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(2), ACACB(9), ACAT1(2), ACOT12(1), ACSS1(3), AKR1B1(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), DLAT(1), DLD(2), GRHPR(2), HAGHL(1), LDHAL6A(2), LDHAL6B(1), LDHB(3), LDHC(3), LDHD(6), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(2), PC(2), PCK1(3), PCK2(1), PDHA1(3), PDHA2(8), PKLR(4), PKM2(3)	12352756	81	60	81	41	23	29	4	16	9	0	0.989	1.000	1.000
393	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(1), BCL2L1(1), CBL(3), CFLAR(2), CRKL(1), E2F1(2), FOS(2), HRAS(5), IL2RB(2), IL2RG(1), IRS1(7), JAK1(2), JAK3(7), MAPK1(1), MAPK3(1), MYC(1), NMI(2), PIK3CA(29), PIK3R1(2), RAF1(1), RPS6KB1(1), SHC1(2), SOCS3(1), SOS1(11), STAT5A(2), SYK(1)	9576466	91	60	77	24	37	29	2	15	8	0	0.241	1.000	1.000
394	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM2(1), CAMK1G(3), FPR1(1), GNA15(1), GNB1(1), HRAS(5), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K6(2), MAP3K1(3), MAPK1(1), MAPK14(1), MAPK3(1), NCF2(3), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), NFKB1(2), PAK1(2), PIK3C2G(8), PLCB1(8), PPP3CA(4), PPP3CB(4), PPP3CC(2), RAC1(1), RAF1(1), RELA(3), SYT1(4)	10152689	83	59	82	38	20	37	6	14	6	0	0.974	1.000	1.000
395	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	B3GALT1(3), B3GALT2(3), B3GALT4(1), B3GNT2(1), B3GNT3(4), B3GNT4(1), B4GALT1(1), B4GALT3(3), B4GALT4(3), B4GALT6(2), FUT2(1), FUT3(3), FUT5(4), FUT6(2), FUT9(5), GBGT1(2), GCNT2(2), PIGB(1), PIGF(1), PIGG(4), PIGH(1), PIGK(1), PIGL(2), PIGN(1), PIGO(2), PIGQ(1), PIGT(1), PIGX(1), PIGZ(2), ST3GAL1(4), ST3GAL4(2), ST3GAL5(2), ST3GAL6(2), ST6GALNAC3(5), ST6GALNAC4(1), ST6GALNAC5(3), ST8SIA1(3), UGCG(1)	12869860	82	59	82	37	21	31	9	12	9	0	0.892	1.000	1.000
396	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(7), ADRBK2(2), CALM2(1), CALML6(1), CAMK2A(1), CAMK2B(2), CAMK2D(1), CLCA1(7), CLCA2(5), CLCA4(3), CNGA3(6), CNGA4(5), CNGB1(4), GNAL(1), GUCA1A(2), GUCA1C(1), PDE1C(13), PRKACB(3), PRKACG(1), PRKG1(6), PRKG2(4), PRKX(1)	8085363	77	59	77	19	17	36	5	8	11	0	0.155	1.000	1.000
397	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(8), BMPR1B(1), CCND2(3), DAZL(1), DMC1(1), EGR1(2), ESR2(2), FSHR(15), GJA4(1), INHA(3), LHCGR(9), MLH1(2), MSH5(3), NCOR1(9), NRIP1(3), PGR(4), PRLR(6), PTGER2(2), SMPD1(4), VDR(4), ZP2(2)	9271043	85	59	85	33	25	28	4	15	13	0	0.915	1.000	1.000
398	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(1), AKT3(3), ANKRD6(1), APC(9), AXIN2(2), CER1(2), CSNK1A1(2), CTNNB1(4), DACT1(5), DKK1(4), DKK2(1), DKK4(1), DVL1(3), FSTL1(2), GSK3A(3), LRP1(15), MVP(2), NKD1(2), NKD2(2), PSEN1(3), SENP2(3), SFRP1(1), WIF1(6)	10726362	77	59	77	28	13	36	4	13	10	1	0.732	1.000	1.000
399	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(5), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH7(1), ADHFE1(2), ALDH3A1(2), ALDH3B2(1), AOC2(2), AOC3(3), AOX1(13), DBH(2), DCT(4), DDC(6), FAH(1), GOT2(3), GSTZ1(2), HGD(4), HPD(1), PNMT(2), TAT(1), TH(2), TPO(10), TYR(10)	8388822	83	59	83	28	17	38	3	19	6	0	0.481	1.000	1.000
400	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	EGFR(7), GNAS(6), GNB1(1), HRAS(5), IGF1R(1), ITGB1(5), KLK2(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MKNK2(1), MYC(1), NGFR(1), PDGFRA(10), PTPRR(9), RAF1(1), RPS6KA1(2), RPS6KA5(4), SHC1(2), SOS1(11), STAT3(2)	8747044	76	58	74	22	18	32	6	16	4	0	0.423	1.000	1.000
401	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(1), AADAC(3), ABAT(4), ACADS(2), ACAT1(2), ACSM1(5), AKR1B10(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH5A1(1), ALDH7A1(1), ALDH9A1(2), BDH1(4), DDHD1(5), ECHS1(1), EHHADH(1), GAD1(5), GAD2(6), HADH(1), HADHA(2), HMGCL(1), HMGCS1(1), HMGCS2(3), HSD17B4(1), ILVBL(2), OXCT1(3), PDHA1(3), PDHA2(8), PLA1A(6), PRDX6(2), RDH11(1), RDH12(2), RDH13(1)	10754671	88	58	88	36	26	33	2	19	8	0	0.888	1.000	1.000
402	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(1), ALPL(3), ALPP(3), ALPPL2(1), ASCC3(10), ATP13A2(1), DDX18(2), DDX19A(1), DDX23(3), DDX4(2), DDX41(2), DDX50(1), DDX51(1), DDX52(1), DDX54(3), DDX55(1), DDX56(1), ENTPD7(2), EP400(9), ERCC3(1), FPGS(2), GCH1(2), GGH(2), IFIH1(4), MOV10L1(7), NUDT8(1), RAD54L(1), SETX(12), SKIV2L2(2), SMARCA2(4)	16616228	86	58	86	42	26	31	9	11	9	0	0.992	1.000	1.000
403	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(3), ARSB(2), FUCA1(2), FUCA2(1), GALNS(3), GBA(4), GNS(1), GUSB(2), HEXA(5), HGSNAT(1), HPSE(3), HPSE2(2), HYAL1(3), IDS(1), IDUA(2), LCT(18), MAN2B1(2), MAN2B2(3), MAN2C1(6), MANBA(2), NEU1(3), NEU2(2), NEU4(2), SPAM1(7)	9102561	80	58	80	25	19	24	6	23	8	0	0.460	1.000	1.000
404	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(3), CAPN1(2), CAPN2(2), CAPNS2(1), CXCR3(1), EGF(6), EGFR(7), HRAS(5), ITGA1(4), ITGB1(5), MAPK1(1), MAPK3(1), MYL2(2), MYLK(8), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PTK2(6), PXN(3), TLN1(6)	8657950	74	58	72	22	19	27	6	14	8	0	0.462	1.000	1.000
405	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(1), BCR(2), CRKL(1), FOS(2), HRAS(5), JAK2(4), JUN(3), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK3(1), MAPK8(3), MYC(1), PIK3CA(29), PIK3R1(2), RAF1(1), SOS1(11), STAT1(2), STAT5A(2)	7435432	76	57	61	15	38	18	4	13	3	0	0.0984	1.000	1.000
406	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(1), CREB1(1), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K6(2), MAP3K1(3), MAPK1(1), MAPK14(1), MAPK3(1), NFKB1(2), PIK3CA(29), PIK3R1(2), RB1(12), RELA(3), SP1(2)	5137124	66	57	53	15	26	17	1	12	10	0	0.296	1.000	1.000
407	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(4), ACAA1(1), ACAA2(1), ACADM(1), ACADS(2), ACAT1(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH6A1(1), ALDH7A1(1), ALDH9A1(2), AOX1(13), AUH(1), BCAT1(1), BCAT2(2), BCKDHB(2), DBT(1), DLD(2), ECHS1(1), EHHADH(1), HADH(1), HADHA(2), HADHB(3), HIBADH(1), HIBCH(1), HMGCL(1), HMGCS1(1), HMGCS2(3), HSD17B4(1), MCCC1(6), MCCC2(1), MCEE(1), MUT(4), OXCT1(3), PCCA(3), PCCB(6)	11412041	83	57	83	23	24	28	5	16	10	0	0.443	1.000	1.000
408	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(7), ATP4B(2), ATP6V0A1(4), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(4), ATP6V1B1(3), ATP6V1B2(1), ATP6V1C1(1), ATP6V1C2(1), ATP6V1D(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(3), ATP7A(9), ATP7B(2), COX10(2), COX4I1(1), COX6B1(2), COX6C(1), NDUFA10(3), NDUFB5(2), NDUFB6(1), NDUFB7(2), NDUFS1(4), NDUFV1(2), NDUFV2(2), PPA2(1), SDHA(3), SDHB(2), UQCRB(1), UQCRFS1(2)	10101736	76	57	76	21	17	24	7	15	13	0	0.352	1.000	1.000
409	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(1), AKT1(1), AKT3(3), DAG1(2), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(14), ITPR3(4), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NFKBIL2(5), PDK1(1), PHKA2(4), PIK3CB(4), PITX2(3), PLD1(7), PLD2(2), PLD3(1), VN1R1(4)	11908451	77	57	76	27	22	28	3	13	11	0	0.569	1.000	1.000
410	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(11), COL4A2(14), COL4A3(10), COL4A4(11), COL4A5(4), COL4A6(10), P4HB(5), SLC23A1(2), SLC23A2(3), SLC2A1(1), SLC2A3(6)	6655402	77	57	77	18	14	41	1	9	12	0	0.313	1.000	1.000
411	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(3), AGT(1), AGTR1(5), AGTR2(3), CMA1(2), COL4A1(11), COL4A2(14), COL4A3(10), COL4A4(11), COL4A5(4), COL4A6(10)	6707563	74	56	74	20	11	42	1	9	11	0	0.568	1.000	1.000
412	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(2), CASP10(3), CASP7(2), CASP8(2), CFLAR(2), DAXX(3), DFFB(2), FADD(1), FAF1(1), JUN(3), LMNA(1), MAP2K4(1), MAP3K1(3), MAP3K7(2), MAPK8(3), PAK1(2), PAK2(1), PRKDC(12), PTPN13(9), RB1(12), RIPK2(2), SPTAN1(4)	11001119	73	56	72	17	21	19	1	14	18	0	0.332	1.000	1.000
413	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(1), ACAA2(1), ACADL(2), ACADM(1), ACADS(2), ACADVL(1), ACAT1(2), ACOX1(2), ACOX3(5), ACSL1(2), ACSL3(2), ACSL4(2), ACSL6(2), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), CPT1A(5), CPT1B(3), CPT1C(3), CPT2(2), CYP4A22(2), DCI(1), ECHS1(1), EHHADH(1), GCDH(2), HADH(1), HADHA(2), HADHB(3), HSD17B4(1), PECI(1)	12969310	72	56	72	24	16	32	4	12	8	0	0.595	1.000	1.000
414	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(5), C5(1), C6(18), C7(12), ICAM1(2), IL1A(1), IL6(1), ITGA4(4), ITGAL(1), ITGB1(5), ITGB2(5), SELP(11), SELPLG(1), TNF(1), VCAM1(5)	6596132	73	56	73	22	17	28	7	13	8	0	0.504	1.000	1.000
415	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(3), EGF(6), EGFR(7), HRAS(5), MAP2K1(2), MAPK1(1), MAPK3(1), PTPRB(17), RAF1(1), RASA1(8), SHC1(2), SOS1(11), SPRY2(1), SPRY3(4)	6619376	69	56	67	16	16	23	4	13	13	0	0.233	1.000	1.000
416	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(3), EEF1B2(1), EEF1D(1), EEF1G(2), EEF2(2), EEF2K(5), EIF2AK1(1), EIF2AK3(8), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B4(1), EIF2B5(3), EIF2S2(1), EIF4A1(5), EIF4A2(2), EIF4G1(10), EIF4G3(4), EIF5(3), EIF5B(1), ETF1(2), GSPT2(1), KIAA0664(3), PABPC1(4), PABPC3(9), PAIP1(2)	11591787	78	56	78	27	31	19	3	14	11	0	0.868	1.000	1.000
417	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(1), B4GALT1(1), FBP2(1), G6PC(3), GALK2(1), GALT(1), GANAB(5), GCK(5), GLA(2), HK1(2), HK2(5), HK3(5), LCT(18), MGAM(5), PFKM(6), PFKP(2), PGM1(1)	8646403	64	55	64	29	18	22	3	13	8	0	0.880	1.000	1.000
418	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(3), BCR(2), BLNK(1), FOS(2), HRAS(5), JUN(3), LYN(2), MAP2K1(2), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8IP3(4), PAPPA(8), RAC1(1), RPS6KA1(2), RPS6KA3(1), SHC1(2), SOS1(11), SYK(1), VAV1(7), VAV2(4), VAV3(1)	8477056	67	55	65	17	20	22	7	12	6	0	0.280	1.000	1.000
419	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(2), AZIN1(1), BTG1(1), CLDN5(1), CLOCK(5), CRY1(3), CRY2(2), EIF4G2(3), ETV6(4), GSTM3(1), GSTP1(1), HERPUD1(1), HSPA8(3), IDI1(1), KLF9(1), MYF6(1), NCKAP1(7), NR1D2(1), PER1(6), PER2(2), PIGF(1), PPP1R3C(2), PSMA4(1), PURA(1), SF3A3(2), TUBB3(2), UCP3(3), UGP2(4), VAPA(1), ZFR(5)	9642096	69	54	69	18	15	21	5	18	10	0	0.426	1.000	1.000
420	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(10), CALM2(1), CREB1(1), FOS(2), GNAI1(3), GNAS(6), GNB1(1), HRAS(5), JUN(3), MAP2K1(2), MAPK3(1), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PRKCA(5), RAF1(1), RPS6KA3(1), SYT1(4)	9193464	85	54	83	28	29	31	7	12	6	0	0.645	1.000	1.000
421	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(5), AGXT(2), AGXT2(2), AKR1B10(2), AOC2(2), AOC3(3), BHMT(2), CBS(4), CHDH(1), CHKA(4), DAO(2), DLD(2), DMGDH(2), GATM(1), GCAT(1), GLDC(4), GNMT(1), PHGDH(2), PIPOX(1), PISD(1), PSAT1(3), PSPH(2), RDH11(1), RDH12(2), RDH13(1), SARDH(6), SARS(2), SARS2(3), SDS(2), TARS(3), TARS2(4)	11290298	73	54	73	25	24	21	4	16	8	0	0.539	1.000	1.000
422	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(6), ANAPC4(3), ANAPC5(5), BTRC(1), CDC16(1), CDC20(1), CDC23(1), CDC27(3), CUL1(4), CUL3(12), FBXW11(1), FBXW7(11), ITCH(2), RBX1(1), SKP1(1), SKP2(2), SMURF1(2), UBA1(3), UBE2C(1), UBE2D1(1), UBE2D2(2), UBE2E2(2), UBE2E3(2), VHL(1), WWP1(3), WWP2(2)	10661306	74	54	72	21	18	19	8	13	16	0	0.660	1.000	1.000
423	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(4), ACE2(3), AGT(1), AGTR1(5), AGTR2(3), ANPEP(8), CMA1(2), CPA3(6), CTSA(3), CTSG(3), ENPEP(11), LNPEP(2), MAS1(3), MME(10), NLN(2), THOP1(1)	5602714	67	54	67	22	14	29	2	12	10	0	0.565	1.000	1.000
424	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(2), ACAT1(2), ADH5(1), AKR1B1(1), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), DLAT(1), DLD(2), GRHPR(2), HAGHL(1), LDHB(3), LDHC(3), LDHD(6), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(2), PC(2), PCK1(3), PDHA1(3), PDHA2(8), PKLR(4), PKM2(3)	9763990	68	54	68	31	18	27	3	13	7	0	0.951	1.000	1.000
425	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(2), CARS(8), DARS(1), EPRS(12), FARS2(2), HARS(2), IARS(3), KARS(3), LARS(1), LARS2(3), MARS(1), NARS(4), RARS(4), SARS(2), TARS(3), WARS(4), WARS2(2), YARS(1)	8494670	58	53	58	15	22	17	3	11	5	0	0.369	1.000	1.000
426	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(2), C1QB(2), C1R(3), C1S(3), C2(2), C3(5), C5(1), C6(18), C7(12), C8A(7), C9(3), MASP1(10), MASP2(1), MBL2(4)	5715871	73	53	73	23	19	25	8	12	9	0	0.582	1.000	1.000
427	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(5), AGXT(2), AGXT2(2), AOC2(2), AOC3(3), BHMT(2), CBS(4), CHDH(1), CHKA(4), CPT1B(3), DAO(2), DLD(2), DMGDH(2), GATM(1), GCAT(1), GLDC(4), PISD(1), PLCB2(5), PLCG1(3), PLCG2(5), PSPH(2), SARDH(6), SARS(2), TARS(3)	11103348	67	53	67	23	24	21	2	14	6	0	0.558	1.000	1.000
428	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(5), ACY1(2), ADC(1), AGMAT(1), ALDH18A1(3), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), AMD1(1), AOC2(2), AOC3(3), ARG1(2), ASL(4), CPS1(30), GATM(1), NAGS(1), ODC1(1), OTC(3), SMS(2)	7788514	71	53	70	19	13	31	5	16	6	0	0.199	1.000	1.000
429	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(7), POLB(1), POLD1(2), POLD2(1), POLD3(1), POLE(7), POLE2(2), POLE4(1), POLG(2), POLG2(2), POLI(3), POLK(3), POLL(2), POLQ(19), PRIM1(3), PRIM2(16), REV1(5), REV3L(4), RFC5(1)	10853991	82	53	81	26	23	25	3	19	12	0	0.765	1.000	1.000
430	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	APC(9), ATF2(3), BMP10(1), BMP4(1), BMP5(8), BMPR1A(3), BMPR2(1), CHRD(6), CTNNB1(4), DVL1(3), FZD1(1), MAP3K7(2), MEF2C(4), MYL2(2), NKX2-5(2), NPPB(1), RFC1(1), TGFB1(1), TGFB2(3), TGFBR2(3), TGFBR3(8), WNT1(1)	9613812	68	52	68	22	21	23	4	11	9	0	0.690	1.000	1.000
431	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(10), CD3D(1), CD4(1), CREBBP(17), GNAS(6), GNB1(1), HLA-DRA(1), HLA-DRB1(2), LCK(3), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PTPRC(7), ZAP70(5)	6064524	65	52	65	23	18	20	6	15	6	0	0.771	1.000	1.000
432	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(2), C1QB(2), C1R(3), C1S(3), C2(2), C3(5), C5(1), C6(18), C7(12), C8A(7), C8B(4), C9(3), MASP1(10)	5581646	72	52	72	25	18	26	8	12	8	0	0.729	1.000	1.000
433	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(10), CD3D(1), CD4(1), CREBBP(17), GNAS(6), GNB1(1), HLA-DRA(1), HLA-DRB1(2), LCK(3), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), PTPRC(7), ZAP70(5)	6064524	65	52	65	23	18	20	6	15	6	0	0.771	1.000	1.000
434	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(5), ALDH3A1(2), ALDH3B2(1), AOC2(2), AOC3(3), DDC(6), EPX(5), ESCO1(2), ESCO2(1), GOT2(3), HPD(1), LPO(2), MPO(4), MYST3(11), MYST4(4), PNPLA3(1), PRDX6(2), SH3GLB1(1), TAT(1), TPO(10)	9053784	67	52	67	35	12	23	5	20	7	0	0.991	1.000	1.000
435	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(1), ALOX12B(1), ALOX15(3), ALOX15B(1), CYP2B6(4), CYP2C18(2), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2J2(1), CYP4A22(2), CYP4F2(3), CYP4F3(2), DHRS4(1), EPHX2(3), GGT1(1), GPX5(2), GPX6(2), LTA4H(2), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PTGES(1), PTGS1(2), PTGS2(1), TBXAS1(2)	10282907	73	52	73	33	23	24	9	9	8	0	0.893	1.000	1.000
436	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ARHGAP1(1), ARHGAP4(2), ARHGAP5(2), ARHGAP6(5), ARHGEF1(2), ARHGEF11(8), ARHGEF5(2), ARPC1A(4), BAIAP2(2), CFL1(2), DIAPH1(1), GSN(2), MYL2(2), MYLK(8), OPHN1(3), PIP5K1A(4), PIP5K1B(2), PPP1R12B(5), ROCK1(5), TLN1(6), VCL(2)	12044969	70	52	68	23	28	21	3	13	5	0	0.643	1.000	1.000
437	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	BRAF(8), CREB1(1), CREB3(2), CREB5(3), DUSP4(2), DUSP6(2), DUSP9(2), EEF2K(5), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), MKNK2(1), MOS(4), NFKB1(2), RAP1A(1), RPS6KA1(2), RPS6KA2(7), RPS6KA3(1), SHC1(2), SOS1(11), SOS2(7), TRAF3(3)	7812826	71	52	70	15	22	20	6	9	14	0	0.147	1.000	1.000
438	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(1), ACAA2(1), ACADL(2), ACADM(1), ACADS(2), ACAT1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH6A1(1), ALDH9A1(2), AOX1(13), BCAT1(1), BCKDHB(2), ECHS1(1), EHHADH(1), HADHA(2), HADHB(3), HIBADH(1), HMGCL(1), MCCC1(6), MCCC2(1), MCEE(1), MUT(4), OXCT1(3), PCCA(3), PCCB(6), SDS(2)	9550784	73	52	73	18	20	25	5	16	7	0	0.291	1.000	1.000
439	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(1), GUSB(2), UGDH(2), UGP2(4), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(4), UGT1A9(3), UGT2A1(3), UGT2A3(6), UGT2B10(4), UGT2B11(5), UGT2B15(3), UGT2B28(5), UGT2B4(8), UGT2B7(2), XYLB(1)	6950041	64	51	64	16	13	21	7	18	5	0	0.351	1.000	1.000
440	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(9), CREBBP(17), CTNNB1(4), DVL1(3), EP300(9), FZD1(1), HDAC1(2), LEF1(3), PITX2(3), TRRAP(14), WNT1(1)	8758785	66	51	65	15	12	25	5	15	9	0	0.204	1.000	1.000
441	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(2), BAG4(1), CASP2(1), CASP8(2), CRADD(1), DFFB(2), FADD(1), JUN(3), LMNA(1), MADD(6), MAP2K4(1), MAP3K1(3), MAP3K7(2), MAPK8(3), PAK1(2), PAK2(1), PRKDC(12), RB1(12), SPTAN1(4), TNF(1), TNFRSF1A(2), TRADD(1)	10424697	64	51	63	24	15	19	0	12	18	0	0.873	1.000	1.000
442	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(1), AKR1B10(2), ALDOA(1), ALDOB(2), FBP2(1), FPGT(4), FUK(2), GMPPA(2), HK1(2), HK2(5), HK3(5), KHK(2), MPI(1), MTMR1(1), MTMR2(2), MTMR6(5), PFKFB1(5), PFKL(2), PFKM(6), PFKP(2), PGM2(4), PMM1(1), RDH11(1), RDH12(2), RDH13(1), SORD(1), TPI1(3)	9849015	66	50	66	22	15	24	5	14	8	0	0.519	1.000	1.000
443	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(3), CHIA(4), CHIT1(5), CMAS(2), CTBS(4), CYB5R1(1), GFPT1(1), GFPT2(4), GNE(2), GNPDA2(4), HEXA(5), HK1(2), HK2(5), HK3(5), MTMR1(1), MTMR2(2), MTMR6(5), NAGK(2), NPL(2), RENBP(2), UAP1(2)	7576689	63	50	63	18	10	28	3	11	11	0	0.435	1.000	1.000
444	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(4), ACACA(2), ACACB(9), ACADM(1), ACAT1(2), ACSS1(3), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH6A1(1), ALDH7A1(1), ALDH9A1(2), ECHS1(1), EHHADH(1), HADHA(2), HIBCH(1), LDHAL6A(2), LDHAL6B(1), LDHB(3), LDHC(3), MCEE(1), MLYCD(1), MUT(4), PCCA(3), PCCB(6), SUCLA2(2), SUCLG2(1)	10492803	63	50	63	22	20	19	4	11	9	0	0.741	1.000	1.000
445	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(1), AASDH(6), AASDHPPT(1), AASS(11), ACAT1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), BBOX1(2), DLST(1), DOT1L(5), ECHS1(1), EHHADH(1), EHMT1(5), EHMT2(1), GCDH(2), HADHA(2), PLOD1(4), PLOD2(5), PLOD3(5), SDS(2), TMLHE(1)	9784000	70	50	70	31	13	25	7	16	9	0	0.944	1.000	1.000
446	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(9), BTRC(1), CCND1(1), CREBBP(17), CSNK1A1(2), CSNK1D(2), CSNK2A1(3), CTBP1(2), CTNNB1(4), DVL1(3), FZD1(1), HDAC1(2), MAP3K7(2), MYC(1), NLK(2), PPARD(2), TLE1(4), WIF1(6), WNT1(1)	7765622	65	50	65	15	18	23	6	9	9	0	0.232	1.000	1.000
447	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(2), ACTN2(10), ACTN3(2), BCAR1(6), CTNNA1(1), CTNNA2(27), CTNNB1(4), PTK2(6), PXN(3), VCL(2)	5049791	63	49	63	29	16	29	3	11	4	0	0.940	1.000	1.000
448	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(8), CD2(1), CD33(3), CD5(2), CD7(1), IFNA1(1), IFNB1(2), IFNG(1), IL10(2), IL12A(1), IL12B(3), IL3(1), IL4(2), ITGAX(9), TLR2(3), TLR4(10), TLR7(3), TLR9(2)	4931288	55	49	54	19	10	23	3	13	6	0	0.556	1.000	1.000
449	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(3), DLAT(1), DLD(2), DLST(1), FH(2), IDH3A(1), IDH3B(4), IDH3G(2), MDH1(1), MDH2(1), OGDH(3), PC(2), PDHA1(3), PDHA2(8), PDHX(1), PDK1(1), PDK2(2), PDK3(3), PDK4(3), PDP2(4), SDHA(3), SDHB(2), SUCLA2(2), SUCLG2(1)	7507034	56	49	56	21	12	22	3	13	6	0	0.781	1.000	1.000
450	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(2), ABAT(4), ADSL(1), ADSS(1), AGXT(2), AGXT2(2), ASL(4), ASNS(5), CAD(11), DARS(1), DDO(2), GAD1(5), GAD2(6), GOT2(3), GPT(1), GPT2(4), NARS(4), PC(2)	6914471	60	48	60	21	17	21	2	14	6	0	0.602	1.000	1.000
451	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCR3(1), CFL1(2), GNAS(6), GNB1(1), HRAS(5), MAP2K1(2), MAPK1(1), MAPK3(1), MYL2(2), NOX1(2), PIK3C2G(8), PLCB1(8), PPP1R12B(5), PRKCA(5), PTK2(6), RAF1(1), ROCK2(3)	6693867	59	48	58	22	14	25	4	11	5	0	0.884	1.000	1.000
452	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(2), ACP2(1), ACPT(2), ALPI(1), ALPL(3), ALPP(3), ALPPL2(1), CYP19A1(4), CYP1A1(7), CYP1A2(1), CYP2A13(1), CYP2A6(5), CYP2A7(1), CYP2B6(4), CYP2C18(2), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2D6(3), CYP2F1(3), CYP2J2(1), CYP3A4(1), CYP3A7(1), CYP4B1(3), CYP4F8(4), PON1(7)	7743427	75	48	75	34	21	24	6	19	5	0	0.922	1.000	1.000
453	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(4), AKT1(1), ANXA1(1), CALM2(1), GNAS(6), GNB1(1), NFKB1(2), NOS3(2), NR3C1(1), PIK3CA(29), PIK3R1(2), RELA(3), SYT1(4)	4733023	57	48	44	15	30	10	4	10	3	0	0.476	1.000	1.000
454	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(1), ACAA2(1), ACAD8(2), ACAD9(3), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), AKR1B10(2), AKR1C4(1), AKR1D1(3), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(1), CYP7A1(6), HADHB(3), LIPA(2), RDH11(1), RDH12(2), RDH13(1), SLC27A5(4), SOAT1(1), SOAT2(2), SRD5A1(2), SRD5A2(2)	8408353	62	48	62	19	15	25	0	15	7	0	0.379	1.000	1.000
455	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(1), ALG10B(1), ALG12(1), ALG13(8), ALG2(3), ALG5(2), ALG6(2), ALG8(1), ALG9(1), B4GALT1(1), B4GALT3(3), DDOST(1), DPM1(1), FUT8(2), GANAB(5), MAN1A1(4), MAN1A2(5), MAN1C1(3), MAN2A1(5), MGAT1(2), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(6), MGAT5B(3), RPN1(1), ST6GAL1(2), STT3B(1)	11216478	74	48	74	28	29	27	2	9	7	0	0.772	1.000	1.000
456	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(13), BST1(1), C9orf95(1), CD38(2), ENPP1(8), ENPP3(6), NADK(1), NADSYN1(7), NMNAT2(2), NMNAT3(1), NNT(10), NT5C1A(2), NT5C1B(2), NT5C2(3), NT5C3(3), NT5E(2), NUDT12(2)	5697708	66	48	66	17	20	24	3	11	8	0	0.290	1.000	1.000
457	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(1), ALOX15(3), CYP4F2(3), CYP4F3(2), EPX(5), GGT1(1), LPO(2), LTA4H(2), MPO(4), PLA2G2A(1), PLA2G2E(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PRDX1(1), PRDX6(2), PTGS1(2), PTGS2(1), TBXAS1(2), TPO(10)	7384189	61	48	61	30	13	23	9	11	5	0	0.950	1.000	1.000
458	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(6), CALM2(1), CRKL(1), HRAS(5), JUN(3), MAP2K1(2), MAP2K2(1), MAP2K3(3), MAP2K4(1), MAP3K1(3), MAPK1(1), MAPK14(1), MAPK3(1), MAPK8(3), PAK1(2), PLCG1(3), PRKCA(5), RAC1(1), RAF1(1), SHC1(2), SOS1(11), SYT1(4)	7514232	61	48	59	21	16	22	5	14	4	0	0.739	1.000	1.000
459	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(2), CHUK(2), FOS(2), IKBKB(2), IRAK1(4), JUN(3), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP3K1(3), MAP3K14(1), MAP3K7(2), MAPK14(1), MAPK8(3), NFKB1(2), PPARA(1), RELA(3), TLR2(3), TLR3(2), TLR4(10), TLR7(3), TLR9(2), TOLLIP(1), TRAF6(5)	9644644	63	48	62	31	18	22	5	9	9	0	0.982	1.000	1.000
460	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(4), ABP1(5), ACADL(2), ACADM(1), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), AOC2(2), AOC3(3), CNDP1(3), DPYD(9), DPYS(6), ECHS1(1), EHHADH(1), GAD1(5), GAD2(6), HADHA(2), MLYCD(1), SDS(2), SMS(2)	7698099	67	47	67	26	14	28	4	13	8	0	0.793	1.000	1.000
461	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(3), CDC42(1), CREB1(1), DAXX(3), HRAS(5), HSPB2(1), MAP2K4(1), MAP2K6(2), MAP3K1(3), MAP3K5(4), MAP3K7(2), MAP3K9(4), MAPK14(1), MAPKAPK2(2), MAPKAPK5(3), MEF2A(3), MEF2C(4), MEF2D(3), MYC(1), PLA2G4A(7), RAC1(1), RPS6KA5(4), SHC1(2), STAT1(2), TGFB1(1), TGFB2(3), TRADD(1)	9723880	68	47	67	28	20	27	4	11	6	0	0.941	1.000	1.000
462	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	ACHE(3), CHAT(9), DBH(2), DDC(6), GAD1(5), GAD2(6), HDC(6), PAH(3), PNMT(2), SLC18A3(8), TH(2), TPH1(2)	3804590	54	46	54	20	13	25	4	9	3	0	0.560	1.000	1.000
463	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(1), CDC42(1), CREB1(1), CREB3(2), CREB5(3), DUSP10(5), EEF2K(5), GADD45A(1), IL1R1(1), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP3K4(4), MAP3K5(4), MAP3K7(2), MAPK1(1), MAPK11(2), MAPK13(2), MAPK14(1), MAPKAPK2(2), MAPKAPK5(3), MKNK2(1), MYEF2(4), NFKB1(2), NR2C2(3), SRF(2), TRAF6(5)	8834077	64	46	64	25	23	21	4	7	9	0	0.868	1.000	1.000
464	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(1), CAMK2B(2), CAMK2D(1), DAG1(2), ITPKA(1), ITPKB(6), ITPR1(6), ITPR2(14), ITPR3(4), NFAT5(3), PDE6A(4), PDE6B(3), PDE6C(1), PDE6H(3), SLC6A13(5), TF(6)	9499351	62	46	61	22	16	24	4	8	10	0	0.637	1.000	1.000
465	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(2), GALNS(3), GNS(1), GUSB(2), HEXA(5), HGSNAT(1), HPSE(3), HPSE2(2), HYAL1(3), IDS(1), IDUA(2), LCT(18), SPAM1(7)	5404724	50	45	50	16	12	17	2	12	7	0	0.519	1.000	1.000
466	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	BLVRA(2), CP(2), CPOX(2), EPRS(12), FECH(2), GUSB(2), HCCS(1), PPOX(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(4), UGT1A9(3), UGT2B15(3), UGT2B4(8), UROD(1), UROS(1)	7265216	55	45	55	16	12	23	5	12	3	0	0.478	1.000	1.000
467	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(7), DLG4(1), EPHB2(6), F2RL1(3), F2RL2(1), F2RL3(1), JUN(3), MAP2K5(1), MAPK1(1), MAPK7(1), MAPK8(3), MYEF2(4), PLD1(7), PLD2(2), PLD3(1), PTK2(6), RAF1(1), RASAL1(8), TEC(4), VAV1(7)	7256214	68	45	67	25	21	27	4	10	6	0	0.717	1.000	1.000
468	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(5), AGT(1), AGTR2(3), EDNRA(1), EDNRB(5), EGF(6), EGFR(7), FOS(2), HRAS(5), JUN(3), MYC(1), NFKB1(2), PLCG1(3), PRKCA(5), RELA(3)	5445118	52	44	49	18	13	19	3	8	9	0	0.638	1.000	1.000
469	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(4), ABP1(5), ACADM(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), AOC2(2), AOC3(3), CNDP1(3), DPYD(9), DPYS(6), ECHS1(1), EHHADH(1), GAD1(5), GAD2(6), HADHA(2), HIBCH(1), MLYCD(1), SMS(2)	7147393	61	44	61	25	13	25	3	12	8	0	0.839	1.000	1.000
470	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(2), CREBBP(17), EP300(9), IKBKB(2), IL1B(1), MAP2K3(3), MAP2K6(2), MAP3K14(1), MAP3K7(2), MAPK11(2), MAPK14(1), NFKB1(2), NR3C1(1), RELA(3), TGFBR2(3), TLR2(3), TNF(1)	7847285	55	44	54	20	11	18	3	12	11	0	0.797	1.000	1.000
471	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(4), ACACA(2), ACADL(2), ACADM(1), ACAT1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH6A1(1), ALDH9A1(2), ECHS1(1), EHHADH(1), HADHA(2), LDHB(3), LDHC(3), MCEE(1), MLYCD(1), MUT(4), PCCA(3), PCCB(6), SDS(2), SUCLA2(2), SUCLG2(1)	8753790	54	44	54	15	15	19	4	9	7	0	0.495	1.000	1.000
472	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(1), CHRNB1(1), CHRNG(4), MUSK(3), PIK3CA(29), PIK3R1(2), PTK2(6), RAPSN(3), TERT(3)	4357633	52	43	39	16	32	12	0	6	2	0	0.352	1.000	1.000
473	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(1), ABAT(4), ACADS(2), ACAT1(2), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH5A1(1), ALDH9A1(2), ECHS1(1), EHHADH(1), GAD1(5), GAD2(6), HADHA(2), HMGCL(1), OXCT1(3), PDHA1(3), PDHA2(8), SDHB(2), SDS(2)	6826931	56	43	56	25	13	25	3	8	7	0	0.921	1.000	1.000
474	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(2), C1QB(2), C1R(3), C1S(3), C2(2), C3(5), C5(1), C6(18), C7(12), C8A(7), C9(3)	4705477	58	43	58	19	14	20	8	8	8	0	0.671	1.000	1.000
475	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(3), EPHA4(1), EPHB1(13), FYN(5), ITGA1(4), ITGB1(5), L1CAM(2), LYN(2), RAP1B(1), SELP(11)	4181179	47	43	47	26	6	18	3	11	9	0	0.995	1.000	1.000
476	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(2), CSF1R(3), E2F1(2), ETS1(2), ETV3(2), FOS(2), HDAC5(1), HRAS(5), JUN(3), NCOR2(7), RBL1(5), RBL2(8), SIN3A(5), SIN3B(3)	6870586	50	43	48	12	17	18	3	7	5	0	0.228	1.000	1.000
477	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(3), ADCY1(10), CAP1(2), CCNB1(2), CDC25C(1), GNAI1(3), GNAS(6), GNB1(1), HRAS(5), MAPK1(1), MAPK3(1), MYT1(4), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), RPS6KA1(2)	5412451	52	43	51	21	12	17	6	13	4	0	0.886	1.000	1.000
478	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(3), ACTN1(2), ACTN2(10), ACTN3(2), CAPN1(2), CAPNS2(1), ITGA1(4), ITGB1(5), ITGB3(4), PTK2(6), PXN(3), RAC1(1), SPTAN1(4), TLN1(6)	7542709	53	43	53	21	13	18	2	14	6	0	0.850	1.000	1.000
479	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM2(1), CHUK(2), EGR2(6), EGR3(2), MAP3K1(3), MYC(1), NFATC1(3), NFATC2(4), NFKB1(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), RELA(3), SYT1(4), VIP(1), VIPR2(3)	7373715	59	43	59	22	14	24	5	9	7	0	0.764	1.000	1.000
480	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(1), CDK5R1(1), CSNK1D(2), DRD1(1), DRD2(4), GRM1(13), PLCB1(8), PPP1CA(1), PPP1R1B(1), PPP3CA(4), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3)	4237842	47	42	47	15	12	20	4	7	4	0	0.495	1.000	1.000
481	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSA(2), ARSB(2), ARSD(1), ARSE(2), GAL3ST1(1), GALC(2), GBA(4), GLA(2), LCT(18), NEU1(3), NEU2(2), NEU4(2), PPAP2B(1), SMPD1(4), SMPD2(1), SPTLC1(1), SPTLC2(3), UGCG(1)	6383971	52	42	52	19	14	19	3	12	4	0	0.657	1.000	1.000
482	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(2), ALOX15(3), CYP1A2(1), CYP2C18(2), CYP2C19(9), CYP2C8(2), CYP2C9(3), CYP2J2(1), CYP3A4(1), CYP3A43(4), CYP3A7(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), RDH11(1), RDH12(2), RDH13(1)	6346784	55	42	55	17	20	17	6	5	7	0	0.404	1.000	1.000
483	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(1), ALDOB(2), FBP2(1), GOT2(3), GPT(1), GPT2(4), MDH1(1), MDH2(1), ME1(2), ME3(2), PGK1(2), PGK2(4), PKLR(4), PKM2(3), RPIA(2), TKT(1), TKTL1(1), TKTL2(12), TPI1(3)	5332929	50	42	50	20	8	20	6	9	7	0	0.763	1.000	1.000
484	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(1), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH7A1(1), ALDH9A1(2), CYP2C19(9), CYP2C9(3), DHRS2(2), DHRSX(4), ECHS1(1), EHHADH(1), ESCO1(2), ESCO2(1), HADHA(2), MYST3(11), MYST4(4), PNPLA3(1), SH3GLB1(1)	8187108	52	42	52	23	15	18	0	10	9	0	0.930	1.000	1.000
485	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(5), ABCC2(6), ABCG2(2), BCHE(12), CES1(2), CES2(1), CYP3A4(1), UGT1A1(1), UGT1A10(2), UGT1A3(1), UGT1A4(1), UGT1A5(3), UGT1A6(1), UGT1A7(2), UGT1A8(4), UGT1A9(3)	6058731	47	42	47	14	9	20	3	13	2	0	0.402	1.000	1.000
486	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(17), EP300(9), LPL(3), NCOA1(6), NCOA2(12), RXRA(2)	4903643	49	42	48	17	10	18	3	11	7	0	0.793	1.000	1.000
487	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(9), CDH1(3), CREBBP(17), EP300(9), MAP2K1(2), MAP3K7(2), MAPK3(1), SKIL(1), TGFB1(1), TGFB2(3), TGFBR2(3)	6794970	51	42	50	14	13	16	2	13	7	0	0.554	1.000	1.000
488	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(5), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH3B2(1), ALDH9A1(2), AOC2(2), AOC3(3), CNDP1(3), DDC(6), HAL(2), HARS(2), HDC(6), HNMT(3), PRPS1(2), PRPS2(1)	6463570	48	41	48	25	6	24	3	12	3	0	0.949	1.000	1.000
489	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(1), ALDOB(2), DERA(1), FBP2(1), G6PD(1), GPI(5), H6PD(3), PFKL(2), PFKM(6), PFKP(2), PGD(1), PGM1(1), PRPS1(2), PRPS1L1(3), PRPS2(1), RBKS(1), RPIA(2), TALDO1(1), TKT(1), TKTL1(1), TKTL2(12)	6439869	50	41	50	18	5	20	6	10	9	0	0.634	1.000	1.000
490	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(2), EXT2(1), EXTL1(5), EXTL2(1), EXTL3(1), HS3ST2(2), HS3ST3A1(1), HS3ST5(4), HS6ST1(5), HS6ST3(3), NDST1(4), NDST2(2), NDST3(4), NDST4(13)	5457456	48	41	48	18	13	18	5	8	4	0	0.681	1.000	1.000
491	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(2), CD3D(1), CXCR3(1), ETV5(1), IFNG(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), IL18R1(2), JAK2(4), JUN(3), MAP2K6(2), MAPK14(1), MAPK8(3), STAT4(5), TYK2(8)	4919124	45	41	44	13	14	18	2	4	7	0	0.533	1.000	1.000
492	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(2), IFNA1(1), IFNB1(2), IKBKB(2), IL1A(1), IL1B(1), IL1R1(1), IL1RAP(2), IL6(1), IRAK1(4), IRAK2(1), IRAK3(4), JUN(3), MAP2K3(3), MAP2K6(2), MAP3K1(3), MAP3K14(1), MAP3K7(2), MAPK14(1), MAPK8(3), NFKB1(2), RELA(3), TGFB1(1), TGFB2(3), TNF(1), TOLLIP(1), TRAF6(5)	7824598	56	41	55	21	17	21	3	9	6	0	0.797	1.000	1.000
493	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(5), ALDH3A1(2), ALDH3B2(1), AOC2(2), AOC3(3), DDC(6), EPX(5), GOT2(3), HPD(1), LPO(2), MPO(4), PRDX1(1), PRDX6(2), TAT(1), TPO(10)	5808702	48	41	48	26	7	19	6	14	2	0	0.972	1.000	1.000
494	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2R(2), F2RL3(1), GNAI1(3), GNB1(1), HRAS(5), ITGA1(4), ITGB1(5), MAP2K1(2), MAPK1(1), MAPK3(1), PLA2G4A(7), PLCB1(8), PRKCA(5), PTGS1(2), PTK2(6), RAF1(1), SYK(1), TBXAS1(2)	6440993	57	41	56	21	14	20	5	13	5	0	0.839	1.000	1.000
495	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(9), CERK(6), CREB1(1), CREB3(2), CREB5(3), DAG1(2), EPHB2(6), FOS(2), ITPKA(1), ITPKB(6), JUN(3), MAP2K4(1), MAP2K7(1), MAPK1(1), MAPK10(1), MAPK8(3), MAPK8IP1(2), MAPK8IP3(4), MAPK9(1)	7529585	55	41	54	19	20	19	4	4	8	0	0.691	1.000	1.000
496	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(3), ABP1(5), AOC2(2), AOC3(3), CES1(2), CES7(2), DDHD1(5), ESCO1(2), ESCO2(1), LIPA(2), MYST3(11), MYST4(4), PLA1A(6), PNPLA3(1), PRDX6(2), SH3GLB1(1)	6727165	52	40	52	23	13	16	1	17	5	0	0.947	1.000	1.000
497	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(3), FOS(2), HRAS(5), IL2RB(2), IL2RG(1), JAK1(2), JAK3(7), JUN(3), LCK(3), MAP2K1(2), MAPK3(1), MAPK8(3), RAF1(1), SHC1(2), SOS1(11), STAT5A(2), SYK(1)	6179385	51	40	49	14	14	18	3	11	5	0	0.383	1.000	1.000
498	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(2), FADD(1), IKBKB(2), IL1A(1), IL1R1(1), IRAK1(4), MAP3K1(3), MAP3K14(1), MAP3K7(2), NFKB1(2), RELA(3), TLR4(10), TNF(1), TNFAIP3(5), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(5)	6444905	47	40	47	21	10	18	6	6	7	0	0.945	1.000	1.000
499	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(1), ANXA4(1), ANXA5(3), ANXA6(5), CYP11A1(2), EDNRA(1), EDNRB(5), HSD11B1(3), HSD11B2(1), PLA2G4A(7), PRL(1), PTGDR(6), PTGER2(2), PTGER4(2), PTGFR(5), PTGIR(1), PTGS1(2), PTGS2(1), TBXAS1(2)	5472131	51	40	51	19	8	20	4	9	10	0	0.724	1.000	1.000
500	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(11), APOA4(3), APOC2(2), APOC3(2), CYP7A1(6), DGAT1(1), HMGCR(1), LDLR(4), LIPC(2), LPL(3), LRP1(15), SCARB1(3), SOAT1(1)	7263820	54	40	54	22	17	21	1	10	5	0	0.745	1.000	1.000
501	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(1), CASP9(3), CHUK(2), GH1(2), GHR(3), NFKB1(2), PDPK1(1), PIK3CA(29), PIK3R1(2), RELA(3)	3741089	48	39	34	12	28	7	3	8	2	0	0.436	1.000	1.000
502	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACO1(2), ACO2(3), CLYBL(1), DLD(2), DLST(1), FH(2), IDH1(2), IDH3A(1), IDH3B(4), IDH3G(2), MDH1(1), MDH2(1), OGDH(3), OGDHL(6), PC(2), PCK1(3), PCK2(1), SDHA(3), SDHB(2), SUCLA2(2), SUCLG2(1)	7895341	45	39	45	25	9	19	1	10	6	0	0.982	1.000	1.000
503	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(3), FUCA1(2), FUCA2(1), HEXA(5), LCT(18), MAN2B1(2), MAN2B2(3), MAN2C1(6), MANBA(2), NEU1(3), NEU2(2), NEU4(2)	5380091	49	39	49	15	12	15	4	14	4	0	0.440	1.000	1.000
504	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(3), F2R(2), F3(1), F5(19), F7(2), FGA(5), FGB(4), FGG(2), PROS1(5), SERPINC1(7)	4338527	50	38	50	13	18	14	6	9	3	0	0.451	1.000	1.000
505	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(1), ALDOA(1), ALDOB(2), FBP2(1), FPGT(4), GCK(5), GMPPA(2), HK1(2), HK2(5), HK3(5), KHK(2), MPI(1), PFKFB1(5), PFKM(6), PFKP(2), PMM1(1), SORD(1), TPI1(3)	6342149	49	38	49	18	15	20	2	8	4	0	0.562	1.000	1.000
506	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(1), GTF2A1(1), GTF2B(2), GTF2E1(2), GTF2F1(1), HDAC3(1), NCOA1(6), NCOA2(12), NCOA3(4), NCOR2(7), POLR2A(2), RARA(1), RXRA(2), TBP(1)	6611801	43	38	43	21	8	18	2	8	7	0	0.963	1.000	1.000
507	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(2), CREBBP(17), EP300(9), FADD(1), HDAC3(1), IKBKB(2), NFKB1(2), RELA(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TRADD(1), TRAF6(5)	5930182	47	38	46	12	11	14	4	10	8	0	0.356	1.000	1.000
508	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(5), C5(1), C6(18), C7(12), C8A(7), C9(3)	3367043	46	37	46	15	9	17	8	6	6	0	0.738	1.000	1.000
509	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(1), CREB1(1), CREBBP(17), EP300(9), NCOA3(4), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), RARA(1), RXRA(2)	5469179	46	37	45	13	9	17	2	13	5	0	0.500	1.000	1.000
510	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(10), CREM(2), FHL5(3), FSHB(2), FSHR(15), GNAS(6), XPO1(2)	2521554	40	37	40	16	11	10	4	13	2	0	0.920	1.000	1.000
511	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(1), HEXA(5), LCT(18), SLC33A1(3), ST3GAL1(4), ST3GAL5(2), ST6GALNAC3(5), ST6GALNAC4(1), ST6GALNAC5(3), ST8SIA1(3)	4350925	45	37	45	15	13	19	2	6	5	0	0.418	1.000	1.000
512	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(5), CALM2(1), CAPN2(2), CAPNS2(1), EP300(9), HDAC1(2), MEF2D(3), NFATC1(3), NFATC2(4), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(5), SYT1(4)	6450147	49	37	48	14	15	16	5	6	7	0	0.506	1.000	1.000
513	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(10), ADRB2(4), GNAS(6), PLCE1(14), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3)	3892558	45	37	44	14	13	16	3	9	4	0	0.590	1.000	1.000
514	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(1), AP2A1(2), AP2M1(1), ARF1(1), BTK(7), EEA1(3), GRASP(1), GSK3A(3), LYN(2), PDPK1(1), PFKL(2), PFKM(6), PFKP(2), PLCG1(3), PRKCE(3), PRKCZ(1), RAC1(1), RPS6KB1(1), VAV2(4)	6624084	45	37	45	20	9	13	7	7	9	0	0.937	1.000	1.000
515	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(1), ACAA2(1), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH7(1), ADHFE1(2), AKR1C4(1), AKR1D1(3), ALDH1A2(4), ALDH1B1(2), ALDH2(2), ALDH3A1(2), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(1), CYP7A1(6), HADHB(3), SOAT2(2), SRD5A1(2), SRD5A2(2)	6160205	46	36	46	14	11	20	0	11	4	0	0.442	1.000	1.000
516	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(3), CSF1R(3), EGF(6), EGFR(7), MET(4), PDGFRA(10), PRKCA(5), SH3GLB1(1), SH3KBP1(4)	5134556	43	36	42	14	13	15	4	5	6	0	0.647	1.000	1.000
517	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(2), BAIAP2(2), CASP1(1), CASP7(2), CASP8(2), GAPDH(2), INSR(10), ITCH(2), MAGI1(8), MAGI2(12), RERE(3), WWP1(3), WWP2(2)	6354020	51	36	51	18	11	16	2	12	10	0	0.779	1.000	1.000
518	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCL3(2), CCR1(3), CCR2(1), CCR3(1), CCR4(3), CCR5(2), CD4(1), CXCR3(1), CXCR4(5), IFNG(1), IFNGR1(4), IFNGR2(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), IL18R1(2), IL4(2), IL4R(2), TGFB1(1), TGFB2(3)	5290782	46	36	46	19	12	14	1	10	9	0	0.833	1.000	1.000
519	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CDK7(1), ERCC3(1), GTF2B(2), GTF2E1(2), GTF2H1(2), GTF2H4(2), ILK(2), POLR1A(3), POLR1B(2), POLR2A(2), POLR2B(6), POLR2E(2), POLR3B(2), POLR3D(2), POLR3E(4), POLR3H(2), TAF5(1), TAF9(2), TBP(1)	9272390	41	36	41	19	12	14	2	5	8	0	0.945	1.000	1.000
520	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(6), DYRK1B(3), GLI2(6), GLI3(9), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3), SHH(2), SMO(1), SUFU(2)	4387307	40	36	40	16	13	15	4	5	3	0	0.765	1.000	1.000
521	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(3), CR1(7), CR2(12), FCGR2B(3), HLA-DRA(1), HLA-DRB1(2), ICAM1(2), ITGAL(1), ITGB2(5), PTPRC(7)	4044777	43	35	43	15	15	12	2	10	4	0	0.725	1.000	1.000
522	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	18	CALM2(1), CDKN1A(2), MARCKS(1), NFATC1(3), NFATC2(4), NFATC3(6), NFATC4(2), PLCG1(3), PPP3CA(4), PPP3CB(4), PPP3CC(2), PRKCA(5), SP1(2), SP3(1), SYT1(4)	5518793	44	35	44	13	14	19	3	4	4	0	0.519	1.000	1.000
523	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(4), BIRC2(1), BIRC3(3), CASP10(3), CASP7(2), CASP8(2), CASP9(3), CFLAR(2), CHUK(2), DFFB(2), FADD(1), GAS2(3), LMNA(1), MAP3K14(1), NFKB1(2), RELA(3), SPTAN1(4), TNFRSF10A(1), TNFRSF10B(1), TRADD(1)	8861633	42	35	41	19	12	8	3	11	8	0	0.939	1.000	1.000
524	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT3(1), AGPAT4(1), AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(7), ENPP6(3), PAFAH1B1(1), PAFAH1B2(1), PLA2G2A(1), PLA2G2E(2), PLA2G2F(2), PLA2G3(2), PLA2G4A(7), PLA2G5(3), PLA2G6(5), PLD1(7), PLD2(2), PPAP2B(1)	6155800	49	35	49	24	12	20	5	6	6	0	0.953	1.000	1.000
525	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(3), FUCA1(2), FUCA2(1), HEXA(5), LCT(18), MAN2C1(6), MANBA(2), NEU1(3), NEU2(2), NEU4(2)	4366068	44	35	44	13	10	14	3	13	4	0	0.436	1.000	1.000
526	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(1), ALDOB(2), FBP2(1), G6PD(1), GPI(5), H6PD(3), PFKM(6), PFKP(2), PGD(1), PGM1(1), PRPS1(2), PRPS1L1(3), PRPS2(1), RBKS(1), RPIA(2), TAL1(4), TALDO1(1), TKT(1)	5409298	38	35	38	16	5	12	4	8	9	0	0.795	1.000	1.000
527	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(1), CARM1(1), CBS(4), GGT1(1), LCMT1(2), LCMT2(1), MARS(1), MAT1A(1), METTL2B(1), METTL6(2), PAPSS2(1), PRMT2(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(6), PRMT8(3), SCLY(1), SEPHS1(3), WBSCR22(3)	6596793	41	34	41	12	11	16	2	2	10	0	0.376	1.000	1.000
528	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(2), ACAD9(3), ADH1A(1), ADH1B(1), ADH1C(1), ADH4(3), ADH5(1), ADH7(1), ADHFE1(2), DHRS2(2), DHRSX(4), ESCO1(2), ESCO2(1), MYST3(11), MYST4(4), PNPLA3(1), SH3GLB1(1)	6626342	41	34	41	17	13	13	0	8	7	0	0.884	1.000	1.000
529	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(2), GALNT10(3), GALNT2(2), GALNT3(3), GALNT6(2), GALNT8(3), GALNT9(1), GCNT1(3), ST3GAL1(4), ST3GAL4(2), WBSCR17(12)	3817187	37	34	36	14	7	15	6	5	4	0	0.761	1.000	1.000
530	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	APC(9), BTRC(1), CTNNB1(4), DLL1(1), DVL1(3), FZD1(1), NOTCH1(18), PSEN1(3), WNT1(1)	5624290	41	34	41	13	7	16	1	6	11	0	0.624	1.000	1.000
531	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(1), BIRC2(1), BIRC3(3), CASP8(2), CFLAR(2), FADD(1), JUN(3), MAP2K4(1), MAP3K3(1), MAP3K7(2), NFKB1(2), NFKB2(2), NFKBIB(1), NFKBIE(1), NFKBIL1(2), NFKBIL2(5), NR2C2(3), RALBP1(1), TNF(1), TNFAIP3(5), TNFRSF1A(2), TNFRSF1B(1), TRADD(1)	7209380	44	34	43	17	14	20	2	3	5	0	0.758	1.000	1.000
532	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(1), ALDOB(2), FBP2(1), GOT2(3), GPT(1), GPT2(4), MDH1(1), MDH2(1), ME1(2), ME2(3), ME3(2), PGK1(2), PKLR(4), PKM2(3), RPIA(2), TKT(1), TPI1(3)	4768734	36	33	36	16	8	12	2	7	7	0	0.829	1.000	1.000
533	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(10), GNAS(6), GNB1(1), PRKAA2(5), PRKAB2(1), PRKACB(3), PRKACG(1), PRKAG2(4), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3)	4039205	38	33	38	12	10	13	5	6	4	0	0.660	1.000	1.000
534	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT1(2), ACOT11(1), DHRS2(2), DHRSX(4), ECHS1(1), EHHADH(1), ESCO1(2), ESCO2(1), FN3K(1), GCDH(2), HADHA(2), MYST3(11), MYST4(4), PNPLA3(1), SH3GLB1(1)	6883700	36	33	36	19	10	9	1	9	7	0	0.981	1.000	1.000
535	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(2), ACP2(1), ACP6(2), ACPT(2), ENPP1(8), ENPP3(6), FLAD1(2), MTMR1(1), MTMR2(2), MTMR6(5), TYR(10)	3953309	41	33	41	12	5	19	4	4	9	0	0.532	1.000	1.000
536	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(2), CD2(1), CD3D(1), CD4(1), CXCR3(1), IFNG(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), JAK2(4), STAT4(5), TYK2(8)	3880627	35	33	35	11	8	12	2	5	8	0	0.627	1.000	1.000
537	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(1), CDK5R1(1), DAB1(6), FYN(5), LRP8(1), RELN(34)	3715868	48	33	48	15	14	12	6	13	3	0	0.700	1.000	1.000
538	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(2), FOS(2), HRAS(5), JUN(3), MAP2K1(2), MAPK1(1), MAPK3(1), MYC(1), NFKB1(2), PLCB1(8), PRKCA(5), RAF1(1), RELA(3), TNF(1)	4110222	37	32	35	15	12	13	4	6	2	0	0.821	1.000	1.000
539	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(10), ADRB2(4), CFTR(8), GNAS(6), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3)	3437821	39	32	39	12	13	13	3	7	3	0	0.564	1.000	1.000
540	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(2), KHK(2), LCT(18), MPI(1), PGM1(1), PYGL(3), PYGM(6), TPI1(3), TREH(1)	3554997	37	32	37	12	8	14	2	7	6	0	0.420	1.000	1.000
541	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(2), GALNS(3), GNS(1), GUSB(2), HEXA(5), IDS(1), IDUA(2), LCT(18)	3778304	34	32	34	12	10	13	1	5	5	0	0.564	1.000	1.000
542	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(1), BCAT2(2), COASY(2), DPYD(9), DPYS(6), ENPP1(8), ENPP3(6), ILVBL(2), PANK1(1), PANK2(1), PANK3(1), PANK4(1), PPCS(1), VNN1(2)	4580363	43	32	43	14	10	16	4	4	9	0	0.618	1.000	1.000
543	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(2), IKBKAP(4), IKBKB(2), LTA(2), MAP3K1(3), MAP3K14(1), NFKB1(2), RELA(3), TANK(4), TNFAIP3(5), TNFRSF1B(1), TRAF1(4), TRAF3(3)	5949035	36	32	36	12	3	10	3	11	9	0	0.722	1.000	1.000
544	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(2), ACO2(3), DLD(2), DLST(1), FH(2), IDH1(2), IDH3A(1), IDH3B(4), IDH3G(2), MDH1(1), MDH2(1), PC(2), PCK1(3), SDHA(3), SDHB(2), SUCLA2(2), SUCLG2(1)	5454441	34	31	34	13	8	14	1	6	5	0	0.739	1.000	1.000
545	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(2), ARHGEF1(2), GNA12(2), GNA13(1), GNB1(1), MYL2(2), MYLK(8), PLCB1(8), PPP1R12B(5), PRKCA(5), ROCK1(5)	5481718	41	31	41	13	15	14	3	6	3	0	0.691	1.000	1.000
546	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM2(1), CAMK1G(3), CAMK2A(1), CAMK2B(2), CAMK2D(1), CAMK4(3), HDAC5(1), MEF2A(3), MEF2C(4), MEF2D(3), PPARA(1), PPP3CA(4), PPP3CB(4), PPP3CC(2), SLC2A4(2), SYT1(4)	5349630	39	31	39	13	11	15	4	4	5	0	0.616	1.000	1.000
547	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(1), AMD1(1), BHMT(2), CBS(4), DNMT1(4), DNMT3A(7), DNMT3B(4), MARS(1), MAT1A(1), MTAP(1), MTR(8), TAT(1)	5477009	35	30	35	13	11	11	1	8	4	0	0.725	1.000	1.000
548	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(17), EP300(9), ESR1(6), MAPK1(1), MAPK3(1), PELP1(1)	3867990	35	30	34	11	4	13	2	12	4	0	0.626	1.000	1.000
549	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	B3GNT2(1), B3GNT3(4), B3GNT4(1), B4GALT1(1), B4GALT3(3), B4GALT4(3), FUT2(1), FUT3(3), FUT5(4), FUT6(2), FUT9(5), GCNT2(2), ST3GAL6(2), ST8SIA1(3)	4260727	35	29	35	14	6	16	5	6	2	0	0.721	1.000	1.000
550	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(5), ATIC(1), FTCD(3), GART(3), MTHFD1(4), MTHFD1L(2), MTHFD2(4), MTHFR(2), MTR(8)	5021303	32	29	32	11	13	9	2	5	3	0	0.632	1.000	1.000
551	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	CASP2(1), CHUK(2), CRADD(1), IKBKB(2), JUN(3), LTA(2), MAP2K3(3), MAP2K4(1), MAP2K6(2), MAP3K1(3), MAP3K14(1), MAP4K2(1), MAPK14(1), MAPK8(3), NFKB1(2), RELA(3), TANK(4), TNF(1), TNFRSF1A(2), TRADD(1)	6394207	39	29	38	19	9	12	2	8	8	0	0.946	1.000	1.000
552	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(2), ACP2(1), ACP6(2), ACPT(2), ALPI(1), ALPL(3), ALPP(3), ALPPL2(1), CMBL(3), CYP3A4(1), CYP3A43(4), CYP3A7(1), DHRS2(2), DHRSX(4), PON1(7), PON2(1), PON3(1)	4754337	39	28	39	17	10	14	3	7	5	0	0.830	1.000	1.000
553	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(2), IL22(2), IL22RA1(1), IL22RA2(1), JAK1(2), JAK2(4), JAK3(7), SOCS3(1), STAT1(2), STAT3(2), STAT5A(2), TYK2(8)	4866410	34	28	34	11	9	14	2	4	5	0	0.436	1.000	1.000
554	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(4), BIRC2(1), BIRC3(3), CASP10(3), CASP7(2), CASP8(2), CASP9(3), DFFB(2), GZMB(1), PRF1(2), SCAP(4), SREBF1(2), SREBF2(3)	4815085	32	28	31	13	10	7	2	9	4	0	0.826	1.000	1.000
555	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(11), MAP2(9), PPP1CA(1), PRKACB(3), PRKACG(1), PRKAR2B(3), PRKCE(3)	4825175	31	27	31	10	8	12	2	5	4	0	0.798	1.000	1.000
556	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(6), EGFR(7), MAP2K1(2), MAP3K1(3), MAPK14(1), NCOR2(7), RARA(1), RXRA(2), THRA(1), THRB(2)	4562313	32	27	31	14	6	14	0	9	3	0	0.858	1.000	1.000
557	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(1), BCAT2(2), IARS(3), IARS2(3), ILVBL(2), LARS(1), LARS2(3), PDHA1(3), PDHA2(8), VARS(5), VARS2(2)	4915355	33	27	33	12	7	15	2	6	3	0	0.712	1.000	1.000
558	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(1), BHMT(2), CBS(4), DNMT1(4), DNMT3A(7), DNMT3B(4), MARS(1), MAT1A(1), MTR(8)	4607304	32	27	32	12	9	11	1	8	3	0	0.730	1.000	1.000
559	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(1), CTSD(2), ESR1(6), GREB1(13), HSPB2(1), MTA1(1), MTA3(2), TUBA8(1)	2906466	27	27	27	15	2	13	2	9	1	0	0.951	1.000	1.000
560	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG5(2), B4GALT1(1), B4GALT3(3), B4GALT5(2), DDOST(1), DPM1(1), FUT8(2), MAN1A1(4), MGAT1(2), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT4B(1), MGAT5(6), RPN1(1), ST6GAL1(2)	5249675	36	27	36	17	12	16	2	4	2	0	0.872	1.000	1.000
561	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(5), ATIC(1), GART(3), MTHFD1(4), MTHFD1L(2), MTHFD2(4), MTHFR(2), MTR(8)	4751037	29	27	29	10	13	8	1	5	2	0	0.623	1.000	1.000
562	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(1), COASY(2), DPYD(9), DPYS(6), ENPP1(8), ENPP3(6), PANK1(1), PANK2(1), PANK3(1), PANK4(1), PPCS(1)	3688257	37	27	37	13	9	13	3	3	9	0	0.747	1.000	1.000
563	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(6), ESR2(2), ITPKA(1), PDE1A(2), PDE1B(3), PLCB1(8), PLCB2(5), PRL(1), VIP(1)	2937008	29	27	29	17	7	15	0	6	1	0	0.981	1.000	1.000
564	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(4), ARHGDIB(2), BIRC2(1), BIRC3(3), CASP1(1), CASP10(3), CASP2(1), CASP4(4), CASP7(2), CASP8(2), CASP9(3), DFFB(2), GZMB(1), LMNA(1), PRF1(2)	5115374	32	26	31	14	9	6	1	9	7	0	0.931	1.000	1.000
565	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT2(1), B3GNT7(1), B4GALT1(1), B4GALT3(3), B4GALT4(3), CHST1(3), CHST2(5), CHST4(2), CHST6(5), FUT8(2), ST3GAL1(4), ST3GAL4(2)	3311497	32	26	32	12	7	21	2	2	0	0	0.477	1.000	1.000
566	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	RPL10L(7), RPL13(1), RPL14(1), RPL19(1), RPL28(1), RPL32(1), RPL37(1), RPL3L(2), RPL7(1), RPL8(2), RPS11(1), RPS12(1), RPS18(1), RPS2(1), RPS20(1), RPS21(1), RPS26(1), RPS6(1), RPS8(2)	6000808	28	26	28	16	11	8	0	7	2	0	0.951	1.000	1.000
567	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(3), CHUK(2), IFNG(1), IKBKB(2), IL4(2), JUN(3), MAP3K1(3), MAP3K5(4), MAP4K5(1), MAPK14(1), MAPK8(3), NFKB1(2), RELA(3), TNFRSF9(1)	5147145	31	25	30	11	10	8	2	7	4	0	0.773	1.000	1.000
568	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(4), AGT(1), AGTR1(5), AGTR2(3), BDKRB2(3), KNG1(9), NOS3(2)	2623263	27	25	27	11	5	12	2	4	4	0	0.699	1.000	1.000
569	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM2(1), CCR5(2), CXCR4(5), FOS(2), JUN(3), MAPK14(1), MAPK8(3), PLCG1(3), PRKCA(5), SYT1(4)	3642690	29	25	28	11	11	10	3	3	2	0	0.730	1.000	1.000
570	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(6), IL4(2), MAF(1), MAP2K3(3), MAPK14(1), NFATC1(3), NFATC2(4), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3)	3178644	31	25	31	17	7	14	2	4	4	0	0.935	1.000	1.000
571	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(1), ASPH(4), COPS5(3), CREB1(1), EP300(9), HIF1A(1), JUN(3), NOS3(2), P4HB(5), VHL(1)	4490412	30	25	28	13	10	7	0	9	4	0	0.921	1.000	1.000
572	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(3), GPLD1(1), PGAP1(5), PIGB(1), PIGF(1), PIGG(4), PIGH(1), PIGK(1), PIGL(2), PIGN(1), PIGO(2), PIGQ(1), PIGT(1), PIGW(2), PIGX(1), PIGZ(2)	6353638	29	25	29	17	5	12	3	4	5	0	0.962	1.000	1.000
573	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1G(3), HDAC9(16), MEF2A(3), MEF2C(4), MEF2D(3), MYOD1(1)	2078409	30	25	30	10	9	13	1	5	2	0	0.612	1.000	1.000
574	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(1), CREBBP(17), DFFB(2), GZMA(4), GZMB(1), HMGB2(1), PRF1(2)	2800041	28	25	28	10	5	10	2	7	4	0	0.713	1.000	1.000
575	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(1), CASP8(2), FADD(1), MAP2K1(2), MAP2K4(1), MAP3K1(3), MAPK1(1), MAPK3(1), MAPK8(3), NFKB1(2), NSMAF(4), RAF1(1), RELA(3), SMPD1(4), TNFRSF1A(2), TRADD(1)	5437653	32	24	32	17	8	10	1	9	4	0	0.968	1.000	1.000
576	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(1), EPX(5), LPO(2), MPO(4), MTHFR(2), PRDX6(2), TPO(10)	3083778	26	24	26	12	8	10	3	5	0	0	0.834	1.000	1.000
577	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(1), EPX(5), LPO(2), MPO(4), PRDX1(1), PRDX6(2), TPO(10)	3125991	25	24	25	13	7	9	4	5	0	0	0.917	1.000	1.000
578	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD86(3), HLA-DRA(1), HLA-DRB1(2), IFNG(1), IFNGR1(4), IFNGR2(1), IL12A(1), IL12B(3), IL12RB1(3), IL12RB2(4), IL18R1(2), IL4(2), IL4R(2)	3366449	29	24	29	10	12	7	0	4	6	0	0.742	1.000	1.000
579	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(3), ARPC1A(4), NCK1(2), NCKAP1(7), NTRK1(4), RAC1(1), WASF1(1), WASF3(1), WASL(2)	4043146	25	23	24	16	6	7	0	6	6	0	0.995	1.000	1.000
580	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS2(2), DHRSX(4), ESCO1(2), ESCO2(1), MYST3(11), MYST4(4), PNPLA3(1), SH3GLB1(1)	4387944	26	23	26	12	8	6	0	7	5	0	0.934	1.000	1.000
581	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BNIP1(2), GOSR1(1), SEC22B(4), SNAP23(1), SNAP25(1), STX10(1), STX11(2), STX16(1), STX19(2), STX2(1), STX5(2), STX7(1), TSNARE1(2), USE1(1), VAMP7(3), YKT6(1)	4401377	26	23	26	14	10	5	3	5	3	0	0.967	1.000	1.000
582	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(2), CLOCK(5), CRY1(3), CRY2(2), CSNK1D(2), NPAS2(2), PER1(6), PER2(2), PER3(2)	4502889	26	23	26	9	7	10	3	5	1	0	0.688	1.000	1.000
583	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	CREB1(1), CREM(2), FOS(2), JUN(3), MAPK3(1), OPRK1(1), POLR2A(2), PRKACB(3), PRKACG(1), PRKAR1A(2), PRKAR1B(2), PRKAR2B(3)	3395542	23	22	22	10	7	8	0	5	3	0	0.817	1.000	1.000
584	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(2), CYSLTR2(1), GPR109B(3), GPR161(2), GPR171(2), GPR18(2), GPR34(1), GPR39(2), GPR45(4), GPR65(3), GPR68(1), GPR75(2), GPR81(1)	2609365	26	22	26	12	8	9	0	8	1	0	0.714	1.000	1.000
585	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(2), MAP3K14(1), MAPK14(1), MAPK8(3), NFKB1(2), RELA(3), TNFRSF13B(2), TNFRSF17(1), TNFSF13(1), TRAF3(3), TRAF5(2), TRAF6(5)	3853892	26	22	26	11	6	7	1	5	7	0	0.882	1.000	1.000
586	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	DHCR7(3), EBP(1), FDFT1(1), FDPS(1), GGPS1(2), HMGCR(1), HSD17B7(1), IDI1(1), IDI2(2), LSS(2), MVD(1), NSDHL(1), PMVK(1), SC5DL(1), SQLE(3), TM7SF2(1)	5112504	23	21	23	7	5	10	1	7	0	0	0.509	1.000	1.000
587	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	16	B3GAT1(2), B3GAT2(2), CHPF(2), CHST11(2), CHST12(1), CHST3(2), CHSY1(2), DSE(4), UST(1), XYLT1(6)	3682842	24	21	24	13	3	9	1	8	3	0	0.928	1.000	1.000
588	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(3), POLR1B(2), POLR1D(1), POLR2A(2), POLR2B(6), POLR2D(1), POLR2E(2), POLR3A(1), POLR3B(2), POLR3G(1), POLR3H(2)	6225063	23	21	23	13	9	7	1	2	4	0	0.952	1.000	1.000
589	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(4), CD44(5), CSF1(2), FCGR3A(4), IL1B(1), IL6R(1), SELL(2), TGFB1(1), TGFB2(3), TNF(1), TNFRSF1A(2), TNFRSF1B(1), TNFRSF8(1)	3534805	28	20	28	11	7	10	2	5	4	0	0.779	1.000	1.000
590	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX15(3), ALOX15B(1), DPEP1(3), GGT1(1), LTA4H(2), PLA2G2A(1), PLA2G6(5), PTGES(1), PTGS1(2), PTGS2(1), TBXAS1(2)	3982745	22	19	22	9	4	14	1	3	0	0	0.625	1.000	1.000
591	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(3), APAF1(4), CASP9(3), DAXX(3), FAS(1), FASLG(1), HSPB2(1), IL1A(1), MAPKAPK2(2), MAPKAPK3(1), TNF(1)	2998501	21	19	20	15	8	5	1	4	3	0	0.997	1.000	1.000
592	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD3D(1), CD8A(2), ICAM1(2), ITGAL(1), ITGB2(5), PTPRC(7), THY1(2)	2844225	21	19	21	11	6	6	1	8	0	0	0.933	1.000	1.000
593	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(1), CD3D(1), CD4(1), ICAM1(2), ITGAL(1), ITGB2(5), PTPRC(7), THY1(2)	2987610	20	19	20	12	6	5	1	7	1	0	0.967	1.000	1.000
594	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(1), CDK5R1(1), EGR1(2), HRAS(5), KLK2(2), MAP2K1(2), MAP2K2(1), MAPK1(1), MAPK3(1), NGFR(1), RAF1(1)	2165029	18	18	17	7	5	9	1	3	0	0	0.581	1.000	1.000
595	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(4), ARHGAP5(2), ARHGDIB(2), CASP1(1), CASP10(3), CASP8(2), CASP9(3), GZMB(1), JUN(3), PRF1(2)	3419095	23	18	21	11	10	2	1	6	4	0	0.951	1.000	1.000
596	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CCL3(2), FLT3(7), IGF1(3), IL1A(1), IL3(1), IL6(1), TGFB1(1), TGFB2(3)	2203477	19	17	19	11	6	7	1	5	0	0	0.959	1.000	1.000
597	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(4), ATF3(1), HBEGF(1), IFNG(1), IL1A(1), IL1R1(1), JUND(2), MYOG(1), NR4A3(3), WDR1(2)	2849921	17	17	17	11	5	7	1	0	4	0	0.989	1.000	1.000
598	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	DHCR7(3), FDFT1(1), FDPS(1), HMGCR(1), HMGCS1(1), IDI1(1), LSS(2), MVD(1), NSDHL(1), PMVK(1), SC5DL(1), SQLE(3)	3497369	17	16	17	6	4	7	0	6	0	0	0.696	1.000	1.000
599	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(2), ACACB(9), FASN(2), MCAT(1), OLAH(2), OXSM(1)	4199649	17	15	17	14	8	5	1	1	2	0	0.990	1.000	1.000
600	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	ECHS1(1), EHHADH(1), HADH(1), HADHA(2), HSD17B4(1), SIRT1(1), SIRT2(3), SIRT7(2), VNN2(5)	3143630	17	15	17	10	2	6	1	4	4	0	0.969	1.000	1.000
601	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B4GALT1(1), B4GALT3(3), B4GALT5(2), FUT8(2), ST3GAL1(4), ST3GAL4(2)	2084891	14	14	14	10	4	7	1	2	0	0	0.973	1.000	1.000
602	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT1(2), BDH1(4), HMGCL(1), HMGCS1(1), HMGCS2(3), OXCT1(3)	1908433	14	12	14	7	6	5	0	3	0	0	0.907	1.000	1.000
603	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	B3GALT1(3), B3GALT2(3), FUT2(1), FUT3(3), ST3GAL4(2)	1910628	12	12	12	6	5	3	2	2	0	0	0.856	1.000	1.000
604	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	GNB1(1), HTR2C(5), PLCB1(8)	1895707	14	12	14	8	4	7	1	2	0	0	0.927	1.000	1.000
605	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(5), AOC2(2), AOC3(3), CES1(2)	1596358	12	11	12	8	0	4	1	7	0	0	0.961	1.000	1.000
606	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(3), LPL(3), NR3C1(1), RXRA(2), TNF(1)	1532756	10	10	10	6	3	5	0	2	0	0	0.897	1.000	1.000
607	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	MDH1(1), ME1(2), PC(2), PDHA1(3), SLC25A11(1)	2451814	9	9	9	10	3	2	0	2	2	0	0.995	1.000	1.000
608	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST2(2), HS3ST3A1(1), XYLT1(6)	1707422	9	8	9	6	1	6	0	2	0	0	0.865	1.000	1.000
609	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	HS3ST2(2), HS3ST3A1(1), XYLT1(6)	1707422	9	8	9	6	1	6	0	2	0	0	0.865	1.000	1.000
610	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(1), ALDOA(1), ALDOB(2), TPI1(3)	1032376	7	7	7	4	2	3	0	2	0	0	0.872	1.000	1.000
611	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(3), RAB11A(1), RAB4A(3)	1138299	7	7	7	13	1	5	0	0	1	0	1.000	1.000	1.000
612	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT1(2), HMGCL(1), OXCT1(3)	897227	6	6	6	3	0	3	0	3	0	0	0.894	1.000	1.000
613	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRNA1(4), SNAP25(1)	864662	5	5	5	3	3	1	0	1	0	0	0.829	1.000	1.000
614	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(1), NR1I3(1), PTGS1(2), PTGS2(1)	1415436	5	4	5	4	1	2	0	2	0	0	0.936	1.000	1.000
615	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ7(1), NDUFA13(2)	1066254	3	3	3	4	1	0	0	2	0	0	0.992	1.000	1.000
616	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2		405624	0	0	0	0	0	0	0	0	0	0	1.000	1.000	1.000
