rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	15	CCND1(1), CDK4(5), CDKN1A(4), CDKN1B(1), CDKN2A(34), CFL1(1), E2F1(5), E2F2(4), MDM2(3), NXT1(2), PRB1(29), TP53(39)	2837450	128	80	100	16	62	3	6	17	40	0	2.23e-09	2.74e-06	0.00169
2	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	12	BRAF(123), CAMP(1), CREB3(1), CREB5(9), MAPK1(4), RAF1(8), SNX13(1), SRC(1), TERF2IP(1)	3751054	149	130	43	30	28	4	6	107	4	0	0.0204	0.000156	0.0480
3	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	13	CCNA1(13), CCND1(1), CCNE1(4), CCNE2(12), CDK4(5), CDKN1B(1), CDKN2A(34), E2F1(5), E2F2(4), E2F4(1), PRB1(29)	3023744	109	77	83	17	61	0	4	19	25	0	2.36e-06	0.0239	1.000
4	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(10)	240807	10	10	10	2	7	1	1	1	0	0	0.124	0.109	1.000
5	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	7	HDAC1(1), MYC(5), SP1(5), SP3(1), TP53(39), WT1(5)	2379389	56	44	50	8	26	2	7	6	15	0	0.000785	0.239	1.000
6	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	16	ABL1(12), CDKN2A(34), E2F1(5), MDM2(3), MYC(5), PIK3CA(8), PIK3R1(3), POLR1A(11), POLR1B(8), POLR1C(1), RAC1(17), RB1(8), TBX2(6), TP53(39), TWIST1(1)	6784714	161	96	127	24	84	8	6	17	43	3	8.21e-10	0.465	1.000
7	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(4)	172740	4	4	4	1	4	0	0	0	0	0	0.482	0.466	1.000
8	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(4), FOSB(5), GRIA2(34), JUND(1), PPP1R1B(2)	1226014	46	39	43	15	28	3	2	6	7	0	0.0690	0.828	1.000
9	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(6), GOT2(5), TAT(17)	883649	28	18	27	7	21	2	2	1	2	0	0.0148	0.883	1.000
10	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(6), DCN(17), FMOD(4), KERA(14), LUM(11)	1178331	52	38	48	16	41	4	3	1	3	0	0.00183	0.888	1.000
11	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(4), IL8(1), SLPI(6)	576974	11	11	11	4	5	1	0	4	1	0	0.437	0.919	1.000
12	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(5), CHRNA1(5), SNAP25(6), STX1A(2)	1097766	18	15	15	3	12	1	0	1	4	0	0.0101	0.946	1.000
13	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2), LIPT1(2)	519728	4	3	4	0	0	2	0	1	1	0	0.334	0.953	1.000
14	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(3), ALDOA(2), ALDOB(12), ALDOC(3)	1324868	20	15	17	4	15	2	0	1	2	0	0.0140	0.973	1.000
15	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(3)	556442	3	3	2	1	2	0	0	1	0	0	0.552	0.984	1.000
16	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(5), CD3E(2), CD3G(1)	377095	8	6	8	5	7	0	0	0	1	0	0.701	0.993	1.000
17	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	16	APAF1(6), ATM(12), BAX(3), BCL2(2), CCND1(1), CCNE1(4), CDK4(5), CDKN1A(4), E2F1(5), MDM2(3), PCNA(2), RB1(8), TIMP3(5), TP53(39)	6033930	99	70	91	19	38	7	8	18	26	2	0.000721	0.994	1.000
18	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	9	CHUK(2), DNAJC3(2), EIF2S1(1), MAP3K14(3), NFKB1(7), NFKBIA(2), RELA(4), TP53(39)	3246095	60	50	54	13	28	4	5	8	15	0	0.00906	0.996	1.000
19	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	12	ACTA1(4), ACTR2(3), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(2), RAC1(17), WASF1(4), WASL(5)	2725894	43	37	34	9	31	2	1	5	4	0	0.0120	0.998	1.000
20	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	8	OXA1L(7), SEC61A2(7), SRP19(6), SRP54(3), SRP68(7), SRP72(1), SRP9(1), SRPR(2)	2568197	34	28	30	9	14	0	3	10	7	0	0.276	0.999	1.000
21	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(2), CASP3(2), CASP8(8), CFL1(1), CFLAR(4), PDE6D(2)	1311615	19	17	19	7	8	1	2	6	2	0	0.523	1.000	1.000
22	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(2), TGDS(1), UGDH(1), UXS1(4)	1296567	8	8	8	9	3	0	1	0	4	0	0.985	1.000	1.000
23	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(3), ECHS1(2), EHHADH(6), HADHA(8), SDS(2)	1624136	21	19	19	8	13	2	0	5	1	0	0.244	1.000	1.000
24	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYB(3), NFYC(1), RB1(8), SP1(5), SP3(1)	2236930	19	16	19	5	2	2	2	6	5	2	0.349	1.000	1.000
25	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(4), ALDH1A2(11), BCMO1(15), RDH5(2)	1310017	32	28	29	11	22	2	1	4	3	0	0.0561	1.000	1.000
26	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	22	CCNA1(13), CCND1(1), CCND2(5), CCND3(2), CCNE1(4), CCNH(2), CDC25A(8), CDK4(5), CDK6(2), CDKN1A(4), CDKN1B(1), CDKN2A(34), CDKN2C(1), E2F1(5), RB1(8), RBL1(10), TFDP1(2)	5417889	107	74	88	24	50	3	6	16	30	2	0.000121	1.000	1.000
27	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(4), IFNG(2), IL12A(3), IL12B(3), IL18(2), IL2(4)	986629	18	9	18	7	12	2	0	2	2	0	0.258	1.000	1.000
28	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(4), NFKB1(7), NFKBIA(2), PLCB1(48), PRKCA(10), RELA(4)	2743472	75	54	70	25	58	3	2	7	5	0	0.0274	1.000	1.000
29	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH6(11), ADH7(13), ADHFE1(5)	1891393	108	71	90	31	83	8	5	9	3	0	0.000740	1.000	1.000
30	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(3), IDI1(1), SQLE(4)	1066021	8	8	8	3	4	1	1	2	0	0	0.478	1.000	1.000
31	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(4), ACADM(5), ACADS(4), ECHS1(2), HADHA(8)	1842666	23	21	23	7	14	2	1	6	0	0	0.263	1.000	1.000
32	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(2), BCKDK(2), CBS(6), CTH(1), MUT(5)	1707246	16	16	16	6	10	2	1	2	1	0	0.356	1.000	1.000
33	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	CAMP(1), DAG1(5), GNAQ(4), ITPKB(7)	2011071	17	17	17	7	11	0	1	1	4	0	0.308	1.000	1.000
34	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(3), HLCS(6)	1038760	9	9	9	9	6	0	1	1	1	0	0.913	1.000	1.000
35	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(13), GAD1(13), HDC(19), PNMT(4), TH(9), TPH1(5)	1997200	63	47	60	26	52	2	2	2	5	0	0.0110	1.000	1.000
36	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(11), LPL(3), NR3C1(7), PPARG(11), RETN(3), RXRA(4), TNF(1)	1954008	40	32	38	14	27	2	0	6	5	0	0.0644	1.000	1.000
37	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), ECHS1(2), EHHADH(6), GCDH(5), HADHA(8), SDHB(1), SDS(2)	2619327	25	21	24	8	17	3	0	4	1	0	0.131	1.000	1.000
38	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1), HMGCL(4), OXCT1(4)	1128896	9	9	9	5	6	1	0	1	1	0	0.721	1.000	1.000
39	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	7	ABO(6), B3GNT1(2), FUT1(3), FUT2(3), FUT9(22), ST8SIA1(1)	2005382	37	33	36	16	27	3	2	4	1	0	0.124	1.000	1.000
40	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(4), MTMR2(2), MTMR6(2), NFS1(3), TPK1(8)	2144617	20	18	19	7	14	1	2	1	1	1	0.383	1.000	1.000
41	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(3), MMP14(2), MMP2(7), MMP9(7), RECK(11), TIMP1(1), TIMP2(1), TIMP3(5), TIMP4(6)	2489661	43	35	41	14	25	3	2	10	3	0	0.0792	1.000	1.000
42	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCR3(10), CSF2(2), HLA-DRA(11), HLA-DRB1(3), IL3(3), IL5(4)	1015009	34	26	33	16	28	1	0	3	2	0	0.0677	1.000	1.000
43	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(2), GLS2(3), GLUD1(2), GLUD2(4)	1523529	11	9	11	7	3	3	1	1	3	0	0.801	1.000	1.000
44	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(12), GOT1(6), GOT2(5), TAT(17), TYR(8)	1576532	48	30	47	20	36	4	3	1	4	0	0.112	1.000	1.000
45	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(4), CDC34(4), CUL1(5), E2F1(5), FBXW7(11), RB1(8), TFDP1(2)	2727106	39	31	38	12	16	2	5	6	8	2	0.129	1.000	1.000
46	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB11A(1), RAB1A(1), RAB27A(3), RAB3A(2), RAB5A(1)	1413500	12	10	12	6	9	1	1	1	0	0	0.515	1.000	1.000
47	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(11), IARS(8), LARS(10), LARS2(4), PDHA1(3), PDHA2(17), PDHB(1)	3377570	54	39	50	13	36	6	1	6	5	0	0.0190	1.000	1.000
48	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(5), AASDHPPT(3), AASS(3), KARS(4)	1559878	15	15	15	5	13	0	0	2	0	0	0.381	1.000	1.000
49	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF2(2), CSF3(4), EPO(5), FLT3(31), IGF1(11), IL11(2), IL1A(4), IL3(3), IL6(2), IL9(1), KITLG(8), TGFB1(1), TGFB2(1), TGFB3(3)	2757762	78	51	73	29	51	7	4	10	6	0	0.0154	1.000	1.000
50	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(3), ACP2(2), ACP5(3), ACPP(8), ENPP1(11), ENPP3(14), FLAD1(9), TYR(8)	3236729	58	42	56	16	37	5	2	5	9	0	0.0201	1.000	1.000
51	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(9), PARK2(8), SNCA(2), SNCAIP(47), UBE2E2(4), UBE2F(4), UBE2G2(1), UBE2L6(2)	2156876	77	56	70	26	58	9	1	4	5	0	0.0245	1.000	1.000
52	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(5), PSMA2(1), PSMA4(1), PSMA5(3), PSMA6(4), PSMB1(1), PSMB10(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMB8(5)	2958849	27	21	27	9	14	2	2	6	3	0	0.342	1.000	1.000
53	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(5), ALAS1(1), ALAS2(5), CPOX(4), FECH(3), HMBS(1), PPOX(3), UROS(1)	2536645	23	20	23	9	15	2	1	2	3	0	0.256	1.000	1.000
54	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(8), CDC25B(4), CDKN1A(4), CHEK1(2), NEK1(8), WEE1(2)	2324381	28	22	28	7	14	5	1	4	4	0	0.164	1.000	1.000
55	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(3), GGPS1(1), IDI1(1), IDI2(1), SQLE(4)	1425377	10	10	10	5	6	1	1	2	0	0	0.588	1.000	1.000
56	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(3), PLCD1(3), PRKCA(10), TGM2(8)	1666546	24	18	23	10	19	2	0	0	3	0	0.0483	1.000	1.000
57	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(2), HADHA(8), HADHB(4), HSD17B10(2), HSD17B4(6), MECR(5), PPT1(4), PPT2(8)	2845585	40	38	38	14	17	4	4	12	3	0	0.277	1.000	1.000
58	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	6	LDLR(14), NR0B2(6), NR1H3(3), NR1H4(13), RXRA(4)	1822148	40	28	40	15	25	7	3	2	3	0	0.0380	1.000	1.000
59	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	12	ATM(12), CDC25A(8), CDC25B(4), CDC25C(4), CDK4(5), CHEK1(2), MYT1(21), RB1(8), TP53(39), WEE1(2)	5889400	105	70	96	28	52	5	6	15	25	2	0.0115	1.000	1.000
60	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(8), ALPL(9), ALPP(9), ALPPL2(11), FPGS(3), GGH(2), SPR(2)	2132193	44	31	41	18	35	5	2	1	1	0	0.0216	1.000	1.000
61	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(6), BAX(3), BCL10(3), BCL2(2), BCL2L11(5), CASP8AP2(7), CASP9(3), CES1(16)	3615720	45	32	44	13	28	6	2	3	6	0	0.0919	1.000	1.000
62	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	13	CREBBP(20), DAXX(9), HRAS(3), PAX3(3), PML(3), RARA(3), RB1(8), SP100(8), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TP53(39)	6290213	103	67	97	29	45	8	10	15	23	2	0.0102	1.000	1.000
63	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(13), CCNE1(4), CDC34(4), CUL1(5), E2F1(5), RB1(8), SKP2(2), TFDP1(2)	2852159	43	35	43	15	24	2	4	6	5	2	0.115	1.000	1.000
64	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(4), DPM2(1), EGR1(4), HRAS(3), KLK2(2), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), NGFR(7), RAF1(8)	2713240	47	41	41	22	24	4	2	10	7	0	0.262	1.000	1.000
65	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(2), CASP7(4), DFFA(2), DFFB(3), GZMB(3), HMGB1(1), HMGB2(1), TOP2A(10), TOP2B(8)	2999482	34	26	34	10	22	1	4	5	2	0	0.232	1.000	1.000
66	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(3), ECHS1(2), EHHADH(6), HADHA(8), HSD17B10(2), HSD17B4(6), NTAN1(1), SIRT2(1), SIRT5(7), SIRT7(2), VNN2(14)	3970064	52	41	50	14	33	5	3	9	2	0	0.0269	1.000	1.000
67	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(9), CS(2), MDH1(1), ME1(19), PC(12), PDHA1(3), SLC25A11(2)	3123056	48	34	47	19	28	5	2	9	4	0	0.0811	1.000	1.000
68	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), CYCS(1), GPD2(2), SDHA(1), SDHB(1), SDHC(2), SDHD(1), UQCRC1(3)	2230829	12	12	12	5	8	0	1	1	2	0	0.477	1.000	1.000
69	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	13	CD2(23), CD34(4), CD3D(5), CD3E(2), CD3G(1), CD4(6), CD58(1), CD8A(2), CSF3(4), IL3(3), IL6(2), IL8(1), KITLG(8)	2055622	62	40	57	27	45	4	2	7	4	0	0.0710	1.000	1.000
70	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	18	DNAJA3(4), IFNG(2), IFNGR1(4), IFNGR2(4), IKBKB(3), JAK2(9), LIN7A(13), NFKB1(7), NFKBIA(2), RB1(8), RELA(4), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TP53(39), USH1C(18), WT1(5)	6047725	129	78	118	34	61	6	8	19	33	2	0.00144	1.000	1.000
71	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(5), AASDH(5), AASDHPPT(3), AASS(3), KARS(4)	2313755	20	18	20	7	17	0	0	2	1	0	0.392	1.000	1.000
72	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(3), ACP2(2), ACP5(3), ACP6(11), ACPP(8), ENPP1(11), ENPP3(14), FLAD1(9), LHPP(1), MTMR1(4), MTMR2(2), MTMR6(2), TYR(8)	5021300	78	51	75	20	49	6	6	7	10	0	0.00523	1.000	1.000
73	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(9), CTH(1), GOT1(6), GOT2(5), LDHA(5), LDHB(2), LDHC(5), MPST(2)	2303403	35	27	33	13	26	1	5	2	1	0	0.118	1.000	1.000
74	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(3), PAPSS2(5), SULT1A2(2), SULT1E1(12), SULT2A1(7), SUOX(4)	2044636	33	19	32	11	26	1	0	2	4	0	0.105	1.000	1.000
75	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(2), NDUFA4(1), NDUFB2(3), NDUFB5(3), NDUFB6(2), NDUFS2(2), NDUFV1(2)	2347626	15	15	15	6	10	0	1	3	1	0	0.551	1.000	1.000
76	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(11), COASY(3), DPYD(56), DPYS(22), ENPP1(11), ENPP3(14), PANK1(2), PANK2(3), PANK3(3), PANK4(6), PPCS(3), UPB1(6)	4653241	140	79	126	38	100	10	4	16	10	0	0.000218	1.000	1.000
77	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(9), CARS2(2), CDO1(5), CTH(1), GOT1(6), GOT2(5), LDHA(5), LDHAL6A(4), LDHAL6B(7), LDHB(2), LDHC(5), MPST(2), SDS(2), SULT1B1(11), SULT1C2(5), SULT1C4(12), SULT4A1(8)	4209458	91	60	87	29	63	3	9	7	9	0	0.00385	1.000	1.000
78	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(4), ENO2(4), ENO3(4), FARS2(4), GOT1(6), GOT2(5), PAH(8), TAT(17), YARS(1)	2799697	53	39	50	21	40	5	2	3	3	0	0.0250	1.000	1.000
79	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(6), CPS1(21), GLS(2), GLUD1(2), GOT1(6)	2558390	38	27	36	15	24	3	2	7	2	0	0.248	1.000	1.000
80	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(4), CDKN1B(1), CUL1(5), E2F1(5), NEDD8(1), RB1(8), SKP2(2), TFDP1(2), UBE2M(1)	2879255	29	28	29	12	11	2	4	4	6	2	0.355	1.000	1.000
81	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(3), AKT2(8), AKT3(4), CDKN1A(4), ELK1(2), GRB2(2), HRAS(3), MAP2K1(10), MAP2K2(3), NGFR(7), NTRK1(15), PIK3CA(8), PIK3CD(7), SHC1(1), SOS1(8)	5331617	85	59	78	28	42	13	2	18	10	0	0.0492	1.000	1.000
82	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(6), CD8A(2), CSF1(10), CSF2(2), CSF3(4), EPO(5), IL11(2), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(5), IL8(1), IL9(1)	2024094	52	35	51	28	37	4	1	4	6	0	0.125	1.000	1.000
83	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(4), FARSA(6), FARSB(5), GOT1(6), GOT2(5), PAH(8), TAT(17), YARS(1), YARS2(2)	2921402	54	39	51	22	39	6	2	2	5	0	0.0514	1.000	1.000
84	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(6), BAX(3), BCL2(2), BIK(2), BIRC2(5), BIRC3(7), CASP3(2), CASP7(4), CASP8(8), CASP9(3), CYCS(1), DFFA(2), DFFB(3), DIABLO(1)	4522355	49	38	49	15	26	5	6	7	5	0	0.149	1.000	1.000
85	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(11), BCAT2(1), COASY(3), DPYD(56), DPYS(22), ENPP1(11), ENPP3(14), ILVBL(4), PANK1(2), PANK2(3), PANK3(3), PANK4(6), PPCS(3), UPB1(6), VNN1(7)	5774266	152	81	138	43	110	10	4	17	11	0	6.21e-05	1.000	1.000
86	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	9	ACO1(5), ACO2(4), FH(3), IDH1(12), IDH2(2), MDH1(1), MDH2(4), SDHB(1)	3008924	32	25	22	14	23	0	2	4	3	0	0.258	1.000	1.000
87	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	247	ACVR1B(3), ACVR1C(9), AKT1(3), AKT2(8), AKT3(4), ARRB1(3), ARRB2(6), ATF2(5), ATF4(7), BDNF(3), BRAF(123), CACNA1A(32), CACNA1B(26), CACNA1C(43), CACNA1D(29), CACNA1E(97), CACNA1F(20), CACNA1G(30), CACNA1H(23), CACNA1I(33), CACNA1S(46), CACNA2D1(10), CACNA2D2(14), CACNA2D3(45), CACNA2D4(18), CACNB1(4), CACNB2(12), CACNB3(2), CACNB4(11), CACNG1(3), CACNG2(9), CACNG3(19), CACNG4(3), CACNG5(10), CACNG6(5), CACNG7(5), CACNG8(1), CASP3(2), CD14(5), CDC25B(4), CDC42(2), CHP(3), CHUK(2), CRK(2), CRKL(2), DAXX(9), DDIT3(2), DUSP10(6), DUSP14(2), DUSP16(4), DUSP2(1), DUSP3(1), DUSP4(1), DUSP5(2), DUSP6(1), DUSP7(2), DUSP8(3), DUSP9(3), ECSIT(2), EGF(18), EGFR(22), ELK1(2), ELK4(7), FAS(5), FASLG(14), FGF1(1), FGF10(2), FGF11(2), FGF12(12), FGF13(6), FGF14(5), FGF16(7), FGF17(2), FGF18(2), FGF19(3), FGF2(2), FGF21(4), FGF23(8), FGF3(5), FGF4(2), FGF5(5), FGF6(6), FGF7(7), FGF8(1), FGF9(4), FGFR1(11), FGFR2(31), FGFR3(9), FGFR4(9), FLNA(15), FLNB(38), FLNC(56), FOS(2), GADD45B(2), GNA12(3), GRB2(2), HRAS(3), IKBKB(3), IL1A(4), IL1B(6), IL1R1(11), IL1R2(7), JUN(1), JUND(1), KRAS(4), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K5(3), MAP2K6(3), MAP2K7(4), MAP3K1(2), MAP3K10(8), MAP3K12(3), MAP3K13(10), MAP3K14(3), MAP3K2(6), MAP3K3(6), MAP3K4(17), MAP3K5(16), MAP3K6(6), MAP3K7(1), MAP4K1(9), MAP4K2(6), MAP4K3(8), MAP4K4(7), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK7(4), MAPK8(1), MAPK8IP1(4), MAPK8IP2(7), MAPK8IP3(8), MAPK9(5), MAPKAPK2(7), MAPKAPK3(3), MAPKAPK5(1), MAPT(10), MEF2C(2), MKNK1(5), MKNK2(2), MOS(5), MRAS(1), MYC(5), NF1(40), NFATC2(9), NFATC4(13), NFKB1(7), NFKB2(4), NLK(5), NR4A1(3), NRAS(67), NTF3(6), NTRK1(15), NTRK2(9), PAK1(4), PAK2(8), PDGFA(1), PDGFB(3), PDGFRA(27), PDGFRB(16), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PPM1A(3), PPM1B(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PPP5C(2), PRKACA(3), PRKACB(4), PRKACG(8), PRKCA(10), PRKCG(13), PRKX(3), PTPN5(11), PTPN7(2), PTPRR(24), RAC1(17), RAC2(1), RAF1(8), RAP1A(2), RAP1B(1), RAPGEF2(9), RASA1(4), RASA2(14), RASGRF1(20), RASGRF2(19), RASGRP1(7), RASGRP2(6), RASGRP3(13), RASGRP4(10), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KA4(4), RPS6KA5(4), RPS6KA6(15), RRAS(1), SOS1(8), SOS2(11), SRF(2), STK4(3), STMN1(3), TAOK1(11), TAOK2(24), TAOK3(3), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(8), TNF(1), TNFRSF1A(3), TP53(39), TRAF2(2), TRAF6(4), ZAK(6)	94257387	2098	218	1846	1096	1274	175	92	350	202	5	0.0208	1.000	1.000
88	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	203	ACTN1(5), ACTN2(21), ACTN3(7), ACTN4(5), APC(19), APC2(9), ARAF(4), ARHGEF1(1), ARHGEF12(11), ARHGEF4(4), ARHGEF6(10), ARHGEF7(3), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), ARPC5(1), BAIAP2(5), BCAR1(4), BDKRB1(5), BDKRB2(9), BRAF(123), CD14(5), CDC42(2), CFL1(1), CHRM1(5), CHRM2(18), CHRM3(19), CHRM4(6), CHRM5(4), CRK(2), CRKL(2), CSK(1), CYFIP1(7), CYFIP2(23), DIAPH1(6), DIAPH2(7), DIAPH3(11), DOCK1(15), EGF(18), EGFR(22), EZR(1), F2(9), F2R(6), FGD1(3), FGD3(8), FGF1(1), FGF10(2), FGF11(2), FGF12(12), FGF13(6), FGF14(5), FGF16(7), FGF17(2), FGF18(2), FGF19(3), FGF2(2), FGF21(4), FGF23(8), FGF3(5), FGF4(2), FGF5(5), FGF6(6), FGF7(7), FGF8(1), FGF9(4), FGFR1(11), FGFR2(31), FGFR3(9), FGFR4(9), FN1(21), GIT1(4), GNA12(3), GNA13(1), GRLF1(12), GSN(6), HRAS(3), IQGAP1(10), IQGAP2(22), IQGAP3(10), ITGA1(18), ITGA10(7), ITGA11(16), ITGA2(11), ITGA2B(10), ITGA3(7), ITGA4(36), ITGA5(20), ITGA6(8), ITGA7(23), ITGA8(36), ITGA9(13), ITGAD(24), ITGAE(16), ITGAL(24), ITGAM(21), ITGAV(9), ITGAX(18), ITGB1(4), ITGB2(13), ITGB3(11), ITGB4(20), ITGB5(6), ITGB6(11), ITGB7(6), ITGB8(17), KRAS(4), LIMK1(4), LIMK2(9), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), MOS(5), MRAS(1), MSN(1), MYH10(13), MYH14(17), MYH9(12), MYL2(5), MYL5(1), MYL7(2), MYL9(2), MYLK(39), MYLK2(10), MYLPF(2), NCKAP1(5), NCKAP1L(30), NRAS(67), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PDGFA(1), PDGFB(3), PDGFRA(27), PDGFRB(16), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PIP4K2A(5), PIP4K2B(3), PIP4K2C(3), PIP5K1A(6), PIP5K1B(18), PIP5K1C(8), PPP1CA(1), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PPP1R12B(8), PTK2(8), PXN(3), RAC1(17), RAC2(1), RAF1(8), RDX(1), RHOA(1), ROCK1(5), ROCK2(12), RRAS(1), SCIN(7), SLC9A1(3), SOS1(8), SOS2(11), SSH1(14), SSH2(7), SSH3(3), TIAM1(25), TIAM2(27), TMSL3(2), VAV1(15), VAV2(3), VAV3(9), VCL(7), WAS(7), WASF1(4), WASF2(4), WASL(5)	91792193	1830	216	1599	829	1118	111	85	357	155	4	3.15e-06	1.000	1.000
89	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	192	ACTB(7), ACTG1(5), ACTN1(5), ACTN2(21), ACTN3(7), ACTN4(5), AKT1(3), AKT2(8), AKT3(4), ARHGAP5(11), BCAR1(4), BCL2(2), BIRC2(5), BIRC3(7), BRAF(123), CAPN2(6), CAV1(1), CCND1(1), CCND2(5), CCND3(2), CDC42(2), CHAD(3), COL11A1(58), COL11A2(36), COL1A1(41), COL1A2(39), COL2A1(29), COL3A1(64), COL4A1(57), COL4A2(30), COL4A4(91), COL4A6(32), COL5A1(63), COL5A2(41), COL5A3(67), COL6A1(8), COL6A2(21), COL6A3(57), COL6A6(53), COMP(7), CRK(2), CRKL(2), CTNNB1(11), DIAPH1(6), DOCK1(15), EGF(18), EGFR(22), ELK1(2), ERBB2(7), FARP2(5), FIGF(4), FLNA(15), FLNB(38), FLNC(56), FLT1(33), FN1(21), FYN(6), GRB2(2), GRLF1(12), GSK3B(2), HGF(23), HRAS(3), IBSP(7), IGF1(11), IGF1R(10), ITGA1(18), ITGA10(7), ITGA11(16), ITGA2(11), ITGA2B(10), ITGA3(7), ITGA4(36), ITGA5(20), ITGA6(8), ITGA7(23), ITGA8(36), ITGA9(13), ITGAV(9), ITGB1(4), ITGB3(11), ITGB4(20), ITGB5(6), ITGB6(11), ITGB7(6), ITGB8(17), JUN(1), KDR(42), LAMA1(37), LAMA2(56), LAMA3(56), LAMA4(11), LAMA5(27), LAMB1(9), LAMB2(11), LAMB3(23), LAMB4(37), LAMC1(10), LAMC2(20), LAMC3(6), MAP2K1(10), MAPK1(4), MAPK10(8), MAPK3(1), MAPK8(1), MAPK9(5), MET(19), MYL2(5), MYL5(1), MYL7(2), MYL9(2), MYLK(39), MYLK2(10), MYLPF(2), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PARVA(1), PARVB(3), PARVG(3), PDGFA(1), PDGFB(3), PDGFC(16), PDGFD(6), PDGFRA(27), PDGFRB(16), PDPK1(4), PGF(1), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PIP5K1C(8), PPP1CA(1), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PRKCA(10), PRKCG(13), PTEN(18), PTK2(8), PXN(3), RAC1(17), RAC2(1), RAF1(8), RAP1A(2), RAP1B(1), RAPGEF1(10), RELN(70), RHOA(1), ROCK1(5), ROCK2(12), SHC1(1), SHC2(7), SHC3(11), SHC4(2), SOS1(8), SOS2(11), SPP1(7), SRC(1), THBS1(27), THBS2(9), THBS3(10), THBS4(11), TLN1(12), TLN2(23), TNC(32), TNN(46), TNR(70), TNXB(132), VASP(3), VAV1(15), VAV2(3), VAV3(9), VCL(7), VEGFA(5), VEGFB(1), VEGFC(19), VTN(7), VWF(49), ZYX(6)	123923966	3091	215	2849	1274	2147	203	90	392	256	3	1.31e-10	1.000	1.000
90	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	74	ARAF(4), BRAF(123), C7orf16(1), CACNA1A(32), CRH(3), CRHR1(6), GNA11(7), GNA12(3), GNA13(1), GNAI1(1), GNAI2(5), GNAI3(2), GNAO1(2), GNAQ(4), GNAS(19), GNAZ(6), GRIA1(39), GRIA2(34), GRIA3(23), GRID2(51), GRM1(16), GRM5(13), GUCY1A2(18), GUCY1A3(29), GUCY1B3(7), GUCY2C(32), GUCY2D(8), GUCY2F(15), HRAS(3), IGF1(11), IGF1R(10), ITPR1(29), ITPR2(17), ITPR3(6), KRAS(4), LYN(6), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), NOS1(58), NOS3(16), NPR1(16), NPR2(14), NRAS(67), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(6), PRKCA(10), PRKCG(13), PRKG1(12), PRKG2(13), RAF1(8), RYR1(87)	36474688	1131	212	895	548	692	65	56	236	81	1	0.000497	1.000	1.000
91	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	126	ARAF(4), BRAF(123), CASP3(2), CD244(8), CD247(3), CD48(4), CHP(3), CSF2(2), FAS(5), FASLG(14), FCER1G(1), FCGR3A(8), FCGR3B(2), FYN(6), GRB2(2), GZMB(3), HLA-A(6), HLA-B(5), HLA-C(1), HLA-E(1), HLA-G(3), HRAS(3), ICAM1(2), ICAM2(4), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(9), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(5), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IFNG(2), IFNGR1(4), IFNGR2(4), ITGAL(24), ITGB2(13), KIR2DL1(21), KIR2DL3(6), KIR2DL4(3), KIR3DL1(17), KIR3DL2(2), KLRC1(4), KLRC2(1), KLRC3(11), KLRD1(5), KLRK1(5), KRAS(4), LAT(1), LCK(12), LCP2(9), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), MICA(3), MICB(3), NCR1(13), NCR2(11), NCR3(3), NFAT5(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NRAS(67), PAK1(4), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PLCG1(9), PLCG2(25), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PRF1(11), PRKCA(10), PRKCG(13), PTK2B(10), PTPN11(9), PTPN6(3), RAC1(17), RAC2(1), RAF1(8), SH2D1A(2), SH2D1B(3), SH3BP2(2), SHC1(1), SHC2(7), SHC3(11), SHC4(2), SOS1(8), SOS2(11), SYK(14), TNF(1), TNFRSF10A(5), TNFRSF10B(2), TNFRSF10C(4), TNFRSF10D(7), TNFSF10(7), TYROBP(4), ULBP1(2), ULBP3(5), VAV1(15), VAV2(3), VAV3(9), ZAP70(8)	37669578	945	210	741	363	525	53	58	244	64	1	1.91e-05	1.000	1.000
92	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(16), ADORA1(6), ADORA2A(2), ADORA2B(1), ADORA3(12), ADRA1A(8), ADRA1B(3), ADRA2A(3), ADRA2B(9), ADRA2C(2), ADRB1(5), ADRB2(2), AGTR1(10), AGTR2(9), AVPR1A(4), AVPR1B(9), AVPR2(1), BDKRB1(5), BDKRB2(9), BRS3(5), C3AR1(4), C5AR1(9), CALCR(15), CALCRL(14), CCKAR(9), CCKBR(10), CGA(1), CHRM1(5), CHRM2(18), CHRM3(19), CHRM4(6), CHRM5(4), CNR1(9), CNR2(4), CRHR1(6), CRHR2(2), CTSG(4), CYSLTR1(4), CYSLTR2(2), DRD1(8), DRD2(15), DRD3(5), DRD4(1), DRD5(22), EDNRA(8), EDNRB(4), F2(9), F2R(6), F2RL1(15), F2RL2(6), F2RL3(3), FPR1(18), FSHB(4), FSHR(15), GABBR1(7), GABBR2(10), GABRA1(16), GABRA2(15), GABRA3(19), GABRA4(12), GABRA5(2), GABRA6(22), GABRB1(16), GABRB2(19), GABRB3(17), GABRD(5), GABRE(20), GABRG1(28), GABRG2(14), GABRG3(7), GABRP(12), GABRQ(7), GABRR1(7), GABRR2(1), GALR1(5), GALR3(2), GH1(3), GH2(10), GHR(25), GHRHR(4), GHSR(8), GIPR(2), GLP1R(11), GLP2R(14), GLRA1(11), GLRA2(5), GLRA3(12), GLRB(26), GNRHR(2), GPR156(10), GPR35(3), GPR50(17), GPR63(6), GPR83(13), GRIA1(39), GRIA2(34), GRIA3(23), GRIA4(23), GRID1(22), GRID2(51), GRIK1(22), GRIK2(20), GRIK3(28), GRIK4(11), GRIK5(10), GRIN1(7), GRIN2A(86), GRIN2B(53), GRIN2C(8), GRIN2D(6), GRIN3A(40), GRIN3B(4), GRM1(16), GRM2(7), GRM3(49), GRM4(19), GRM5(13), GRM6(24), GRM7(32), GRM8(43), GRPR(5), GZMA(11), HCRTR1(2), HCRTR2(26), HRH1(14), HRH2(3), HRH3(4), HRH4(5), HTR1A(8), HTR1B(1), HTR1D(3), HTR1E(5), HTR1F(7), HTR2A(8), HTR2B(2), HTR2C(10), HTR4(9), HTR5A(16), HTR6(1), HTR7(8), LEP(2), LEPR(22), LHCGR(24), LTB4R(1), LTB4R2(1), MAS1(3), MC2R(5), MC3R(7), MC4R(1), MC5R(7), MCHR1(3), MCHR2(14), MLNR(1), MTNR1A(8), MTNR1B(7), NMBR(6), NMUR1(6), NMUR2(14), NPBWR1(2), NPBWR2(10), NPFFR1(1), NPFFR2(11), NPY1R(25), NPY2R(12), NPY5R(22), NR3C1(7), NTSR1(6), NTSR2(3), OPRD1(2), OPRK1(21), OPRL1(5), OPRM1(5), OXTR(5), P2RX1(3), P2RX2(2), P2RX3(9), P2RX4(2), P2RX5(8), P2RX7(5), P2RY1(4), P2RY10(6), P2RY13(4), P2RY14(8), P2RY2(8), P2RY6(1), P2RY8(6), PARD3(15), PPYR1(12), PRL(1), PRLHR(1), PRLR(29), PRSS1(25), PRSS3(4), PTAFR(2), PTGDR(9), PTGER2(6), PTGER3(3), PTGER4(1), PTGFR(20), PTGIR(5), PTH2R(14), RXFP1(15), RXFP2(22), SCTR(7), SSTR1(10), SSTR2(5), SSTR3(11), SSTR4(3), SSTR5(3), TAAR1(2), TAAR2(9), TAAR5(3), TAAR6(11), TAAR8(7), TAAR9(3), TACR1(7), TACR2(7), TACR3(25), TBXA2R(4), THRA(2), THRB(14), TRHR(19), TRPV1(2), TSHB(6), TSHR(8), UTS2R(1), VIPR1(4), VIPR2(5)	73362745	2385	209	2212	1473	1692	196	78	221	196	2	7.95e-09	1.000	1.000
93	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	67	ADCY1(26), ADCY8(45), ARAF(4), ATF4(7), BRAF(123), CACNA1C(43), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CAMK4(10), CHP(3), CREBBP(20), EP300(14), GNAQ(4), GRIA1(39), GRIA2(34), GRIN1(7), GRIN2A(86), GRIN2B(53), GRIN2C(8), GRIN2D(6), GRM1(16), GRM5(13), HRAS(3), ITPR1(29), ITPR2(17), ITPR3(6), KRAS(4), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), NRAS(67), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PPP1CA(1), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PPP1R1A(4), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PRKACA(3), PRKACB(4), PRKACG(8), PRKCA(10), PRKCG(13), PRKX(3), RAF1(8), RAP1A(2), RAP1B(1), RAPGEF3(12), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KA6(15)	32848314	989	207	770	477	571	66	57	232	62	1	0.00741	1.000	1.000
94	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	131	ACACA(21), ACACB(17), AKT1(3), AKT2(8), AKT3(4), ARAF(4), BRAF(123), CALM1(1), CALM2(1), CALML3(6), CBL(8), CBLB(16), CBLC(14), CRK(2), CRKL(2), EIF4EBP1(1), ELK1(2), EXOC7(8), FASN(17), FBP1(2), FBP2(2), FLOT1(2), FOXO1(6), G6PC(5), G6PC2(4), GCK(17), GRB2(2), GSK3B(2), GYS1(3), GYS2(20), HRAS(3), IKBKB(3), INPP5D(31), INSR(20), IRS1(5), IRS2(2), IRS4(12), KRAS(4), LIPE(8), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK10(8), MAPK3(1), MAPK8(1), MAPK9(5), MKNK1(5), MKNK2(2), NRAS(67), PCK1(23), PCK2(4), PDE3A(24), PDE3B(6), PDPK1(4), PFKL(4), PFKM(1), PHKA1(19), PHKA2(7), PHKB(7), PHKG1(1), PHKG2(2), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PKLR(11), PKM2(5), PPARGC1A(20), PPP1CA(1), PPP1CB(5), PPP1CC(2), PPP1R3A(55), PPP1R3B(6), PPP1R3C(3), PPP1R3D(3), PRKAA1(1), PRKAA2(24), PRKAB1(2), PRKAB2(2), PRKACA(3), PRKACB(4), PRKACG(8), PRKAG1(2), PRKAG2(7), PRKAG3(10), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCI(8), PRKCZ(5), PRKX(3), PTPN1(4), PTPRF(27), PYGB(2), PYGL(7), PYGM(10), RAF1(8), RAPGEF1(10), RHEB(1), RHOQ(1), RPS6(1), RPS6KB1(2), RPS6KB2(3), SH2B2(4), SHC1(1), SHC2(7), SHC3(11), SHC4(2), SLC2A4(8), SOCS2(2), SOCS3(2), SOCS4(3), SORBS1(13), SOS1(8), SOS2(11), SREBF1(5), TRIP10(4), TSC1(5), TSC2(11)	53356679	1075	207	874	411	609	65	65	255	79	2	5.33e-07	1.000	1.000
95	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	85	ABL1(12), ABL2(10), AKT1(3), AKT2(8), AKT3(4), ARAF(4), AREG(7), BRAF(123), BTC(2), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CBL(8), CBLB(16), CBLC(14), CDKN1A(4), CDKN1B(1), CRK(2), CRKL(2), EGF(18), EGFR(22), EIF4EBP1(1), ELK1(2), ERBB2(7), ERBB3(5), ERBB4(47), EREG(4), GAB1(4), GRB2(2), GSK3B(2), HBEGF(1), HRAS(3), JUN(1), KRAS(4), MAP2K1(10), MAP2K2(3), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK3(1), MAPK8(1), MAPK9(5), MYC(5), NCK1(1), NCK2(4), NRAS(67), NRG1(14), NRG2(7), NRG3(20), NRG4(1), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PLCG1(9), PLCG2(25), PRKCA(10), PRKCG(13), PTK2(8), RAF1(8), RPS6KB1(2), RPS6KB2(3), SHC1(1), SHC2(7), SHC3(11), SHC4(2), SOS1(8), SOS2(11), SRC(1), STAT5A(2), STAT5B(4), TGFA(2)	34254343	806	205	608	278	415	45	57	235	53	1	1.15e-05	1.000	1.000
96	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(7), ACTG1(5), CHAD(3), COL11A1(58), COL11A2(36), COL17A1(27), COL1A1(41), COL1A2(39), COL2A1(29), COL3A1(64), COL4A1(57), COL4A2(30), COL4A4(91), COL4A6(32), COL5A1(63), COL5A2(41), COL5A3(67), COL6A1(8), COL6A2(21), COL6A3(57), COL6A6(53), COMP(7), DES(8), DSC1(42), DSC2(36), DSC3(37), DSG1(56), DSG2(21), DSG3(60), DSG4(56), FN1(21), GJA1(7), GJA10(13), GJA3(1), GJA4(4), GJA5(7), GJA8(18), GJA9(3), GJB1(1), GJB2(3), GJB3(3), GJB4(6), GJB5(6), GJB6(6), GJB7(2), GJC1(6), GJC3(1), GJD2(5), IBSP(7), INA(4), ITGA6(8), ITGB4(20), KRT1(19), KRT10(14), KRT12(11), KRT13(11), KRT14(2), KRT15(10), KRT16(11), KRT17(8), KRT18(3), KRT2(17), KRT20(7), KRT23(8), KRT24(7), KRT25(10), KRT27(5), KRT28(10), KRT3(13), KRT31(8), KRT32(10), KRT33A(5), KRT33B(3), KRT34(10), KRT35(8), KRT36(16), KRT37(11), KRT38(8), KRT39(12), KRT4(17), KRT40(6), KRT5(15), KRT6A(16), KRT6B(8), KRT6C(13), KRT7(5), KRT71(15), KRT72(11), KRT73(15), KRT74(13), KRT75(14), KRT76(12), KRT77(13), KRT78(19), KRT79(8), KRT8(6), KRT81(3), KRT82(8), KRT83(14), KRT84(10), KRT85(7), KRT86(7), KRT9(19), LAMA1(37), LAMA2(56), LAMA3(56), LAMA4(11), LAMA5(27), LAMB1(9), LAMB2(11), LAMB3(23), LAMB4(37), LAMC1(10), LAMC2(20), LAMC3(6), LMNA(8), LMNB1(2), LMNB2(4), NES(21), PRPH(1), RELN(70), SPP1(7), THBS1(27), THBS2(9), THBS3(10), THBS4(11), TNC(32), TNN(46), TNR(70), TNXB(132), VIM(5), VTN(7), VWF(49)	83420384	2649	204	2524	1115	1992	194	62	206	194	1	3.07e-11	1.000	1.000
97	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	168	ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY7(10), ADCY8(45), ADCY9(9), ADORA2A(2), ADORA2B(1), ADRA1A(8), ADRA1B(3), ADRA1D(4), ADRB1(5), ADRB2(2), AGTR1(10), ATP2A1(9), ATP2A2(12), ATP2A3(14), ATP2B1(6), ATP2B2(24), ATP2B3(9), ATP2B4(15), AVPR1A(4), AVPR1B(9), BDKRB1(5), BDKRB2(9), BST1(1), CACNA1A(32), CACNA1B(26), CACNA1C(43), CACNA1D(29), CACNA1E(97), CACNA1F(20), CACNA1G(30), CACNA1H(23), CACNA1I(33), CACNA1S(46), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CAMK4(10), CCKAR(9), CCKBR(10), CD38(4), CHP(3), CHRM1(5), CHRM2(18), CHRM3(19), CHRM5(4), CHRNA7(3), CYSLTR1(4), CYSLTR2(2), DRD1(8), EDNRA(8), EDNRB(4), EGFR(22), ERBB2(7), ERBB3(5), ERBB4(47), F2R(6), GNA11(7), GNA14(5), GNA15(5), GNAL(2), GNAQ(4), GNAS(19), GRIN1(7), GRIN2A(86), GRIN2C(8), GRIN2D(6), GRM1(16), GRM5(13), GRPR(5), HRH1(14), HRH2(3), HTR2A(8), HTR2B(2), HTR2C(10), HTR4(9), HTR5A(16), HTR6(1), HTR7(8), ITPKB(7), ITPR1(29), ITPR2(17), ITPR3(6), LHCGR(24), LTB4R2(1), MYLK(39), MYLK2(10), NOS1(58), NOS3(16), NTSR1(6), OXTR(5), P2RX1(3), P2RX2(2), P2RX3(9), P2RX4(2), P2RX5(8), P2RX7(5), PDE1A(35), PDE1B(12), PDE1C(41), PDGFRA(27), PDGFRB(16), PHKA1(19), PHKA2(7), PHKB(7), PHKG1(1), PHKG2(2), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PLCD1(3), PLCD3(3), PLCD4(2), PLCE1(48), PLCG1(9), PLCG2(25), PLCZ1(20), PPID(1), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PRKACA(3), PRKACB(4), PRKACG(8), PRKCA(10), PRKCG(13), PRKX(3), PTAFR(2), PTGER3(3), PTGFR(20), PTK2B(10), RYR1(87), RYR2(84), RYR3(81), SLC25A6(2), SLC8A1(27), SLC8A2(9), SLC8A3(34), SPHK1(1), SPHK2(7), TACR1(7), TACR2(7), TACR3(25), TBXA2R(4), TNNC1(2), TNNC2(3), TRHR(19), TRPC1(5), VDAC1(1), VDAC2(1), VDAC3(1)	88839491	2270	203	2142	1481	1631	161	76	198	200	4	0.0192	1.000	1.000
98	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	250	ACVR1(2), ACVR1B(3), ACVR2A(3), ACVR2B(3), AMHR2(15), BMP2(4), BMP7(2), BMPR1A(2), BMPR1B(3), BMPR2(5), CCL1(1), CCL11(1), CCL14(2), CCL15(3), CCL16(1), CCL18(1), CCL2(1), CCL20(2), CCL21(2), CCL22(1), CCL24(3), CCL25(1), CCL26(1), CCL27(2), CCL28(1), CCL7(4), CCL8(3), CCR1(9), CCR2(16), CCR3(10), CCR4(7), CCR5(7), CCR6(2), CCR7(3), CCR8(6), CCR9(5), CD27(3), CD40(4), CD40LG(2), CLCF1(1), CNTF(1), CNTFR(3), CSF1(10), CSF1R(12), CSF2(2), CSF2RA(17), CSF2RB(17), CSF3(4), CSF3R(6), CX3CL1(4), CX3CR1(13), CXCL10(3), CXCL11(1), CXCL12(2), CXCL13(1), CXCL14(1), CXCL3(1), CXCL5(2), CXCL6(1), CXCL9(2), CXCR3(4), CXCR4(3), CXCR6(4), EDA(2), EDA2R(3), EDAR(5), EGF(18), EGFR(22), EPO(5), EPOR(1), FAS(5), FASLG(14), FLT1(33), FLT3(31), FLT3LG(2), FLT4(23), GDF5(13), GH1(3), GH2(10), GHR(25), HGF(23), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(9), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(5), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IFNG(2), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(4), IL10(3), IL10RA(7), IL10RB(5), IL11(2), IL11RA(3), IL12A(3), IL12B(3), IL12RB1(15), IL12RB2(3), IL13(2), IL13RA1(3), IL15(3), IL15RA(6), IL17A(9), IL17B(3), IL17RA(4), IL17RB(2), IL18(2), IL18R1(17), IL18RAP(16), IL19(2), IL1A(4), IL1B(6), IL1R1(11), IL1R2(7), IL1RAP(4), IL2(4), IL20(4), IL20RA(9), IL21(6), IL21R(17), IL22(1), IL22RA1(11), IL22RA2(1), IL23A(2), IL23R(7), IL25(2), IL26(3), IL28A(1), IL28B(4), IL28RA(4), IL29(1), IL2RA(4), IL2RB(7), IL2RG(3), IL3(3), IL3RA(7), IL4(1), IL4R(13), IL5(4), IL5RA(12), IL6(2), IL6R(4), IL6ST(10), IL7(5), IL7R(27), IL8(1), IL9(1), IL9R(5), INHBA(16), INHBB(7), INHBC(11), INHBE(3), KDR(42), KIT(9), KITLG(8), LEP(2), LEPR(22), LIF(2), LIFR(33), LTA(2), LTB(2), MET(19), MPL(7), NGFR(7), OSM(5), OSMR(35), PDGFB(3), PDGFC(16), PDGFRA(27), PDGFRB(16), PLEKHO2(5), PPBP(5), PRL(1), PRLR(29), RELT(2), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(8), TNF(1), TNFRSF10A(5), TNFRSF10B(2), TNFRSF10C(4), TNFRSF10D(7), TNFRSF11A(5), TNFRSF11B(10), TNFRSF12A(1), TNFRSF13B(8), TNFRSF14(2), TNFRSF17(6), TNFRSF18(4), TNFRSF19(2), TNFRSF1A(3), TNFRSF1B(3), TNFRSF21(10), TNFRSF25(5), TNFRSF4(4), TNFRSF6B(2), TNFRSF8(17), TNFRSF9(4), TNFSF10(7), TNFSF11(4), TNFSF12(1), TNFSF13B(1), TNFSF14(7), TNFSF15(7), TNFSF18(7), TNFSF4(3), TNFSF8(3), TNFSF9(1), TPO(40), TSLP(1), VEGFA(5), VEGFB(1), VEGFC(19), XCL1(1), XCL2(2), XCR1(4)	58991422	1471	202	1414	799	1055	101	38	131	146	0	0.0221	1.000	1.000
99	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(12), CD36(4), CD44(5), CD47(1), CHAD(3), COL11A1(58), COL11A2(36), COL1A1(41), COL1A2(39), COL2A1(29), COL3A1(64), COL4A1(57), COL4A2(30), COL4A4(91), COL4A6(32), COL5A1(63), COL5A2(41), COL5A3(67), COL6A1(8), COL6A2(21), COL6A3(57), COL6A6(53), DAG1(5), FN1(21), FNDC1(32), FNDC3A(9), FNDC4(5), FNDC5(3), GP5(4), GP6(5), GP9(6), HMMR(4), HSPG2(24), IBSP(7), ITGA1(18), ITGA10(7), ITGA11(16), ITGA2(11), ITGA2B(10), ITGA3(7), ITGA4(36), ITGA5(20), ITGA6(8), ITGA7(23), ITGA8(36), ITGA9(13), ITGAV(9), ITGB1(4), ITGB3(11), ITGB4(20), ITGB5(6), ITGB6(11), ITGB7(6), ITGB8(17), LAMA1(37), LAMA2(56), LAMA3(56), LAMA4(11), LAMA5(27), LAMB1(9), LAMB2(11), LAMB3(23), LAMB4(37), LAMC1(10), LAMC2(20), LAMC3(6), RELN(70), SDC1(3), SDC2(2), SDC3(6), SDC4(3), SPP1(7), SV2A(16), SV2B(29), SV2C(14), THBS1(27), THBS2(9), THBS3(10), THBS4(11), TNC(32), TNN(46), TNR(70), TNXB(132), VTN(7), VWF(49)	74870946	2072	202	1988	871	1552	121	61	170	167	1	0.000160	1.000	1.000
100	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	127	ABL1(12), ABLIM1(12), ABLIM2(6), ABLIM3(7), ARHGEF12(11), CDC42(2), CDK5(4), CFL1(1), CHP(3), CXCL12(2), CXCR4(3), DCC(76), DPYSL2(4), DPYSL5(11), EFNA2(1), EFNA4(2), EFNA5(3), EFNB1(1), EFNB3(2), EPHA1(15), EPHA2(15), EPHA3(25), EPHA4(17), EPHA5(7), EPHA6(60), EPHA7(42), EPHA8(16), EPHB1(25), EPHB2(29), EPHB3(14), EPHB4(10), EPHB6(22), FES(5), FYN(6), GNAI1(1), GNAI2(5), GNAI3(2), GSK3B(2), HRAS(3), ITGB1(4), KRAS(4), L1CAM(8), LIMK1(4), LIMK2(9), LRRC4C(39), MAPK1(4), MAPK3(1), MET(19), NCK1(1), NCK2(4), NFAT5(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NGEF(13), NRAS(67), NRP1(18), NTN4(16), NTNG1(14), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PLXNA1(14), PLXNA2(9), PLXNA3(10), PLXNB1(20), PLXNB2(16), PLXNB3(6), PLXNC1(16), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PTK2(8), RAC1(17), RAC2(1), RASA1(4), RGS3(12), RHOA(1), RHOD(2), RND1(5), ROBO1(22), ROBO2(33), ROBO3(14), ROCK1(5), ROCK2(12), SEMA3A(11), SEMA3B(2), SEMA3C(3), SEMA3D(11), SEMA3E(22), SEMA3F(10), SEMA3G(13), SEMA4A(8), SEMA4B(4), SEMA4C(7), SEMA4D(9), SEMA4F(6), SEMA4G(8), SEMA5A(18), SEMA5B(16), SEMA6A(8), SEMA6B(7), SEMA6C(8), SEMA6D(4), SEMA7A(3), SLIT1(16), SLIT2(56), SLIT3(45), SRGAP1(6), SRGAP2(7), SRGAP3(32), UNC5A(8), UNC5B(9), UNC5C(16), UNC5D(23)	65059039	1479	198	1344	733	988	109	61	200	119	2	0.00143	1.000	1.000
101	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	78	ABL1(12), ACTN1(5), ACTR2(3), ACTR3(2), AKT1(3), AKT2(8), AKT3(4), ANGPTL2(2), ARHGEF6(10), ARHGEF7(3), BCAR1(4), BRAF(123), CAV1(1), CDC42(2), CDKN2A(34), CRK(2), CSE1L(5), DOCK1(15), EPHB2(29), FYN(6), GRB2(2), GRB7(5), GRLF1(12), ITGA1(18), ITGA10(7), ITGA11(16), ITGA2(11), ITGA3(7), ITGA4(36), ITGA5(20), ITGA6(8), ITGA7(23), ITGA8(36), ITGA9(13), ITGB3BP(2), MAP2K4(4), MAP2K7(4), MAP3K11(6), MAPK1(4), MAPK10(8), MAPK8(1), MAPK8IP1(4), MAPK8IP2(7), MAPK8IP3(8), MAPK9(5), MRAS(1), MYLK(39), MYLK2(10), P4HB(2), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PIK3CA(8), PIK3CB(21), PKLR(11), PLCG1(9), PLCG2(25), PTEN(18), PTK2(8), RAF1(8), RALA(1), RHO(2), ROCK1(5), ROCK2(12), SHC1(1), SOS1(8), SOS2(11), SRC(1), TERF2IP(1), TLN1(12), TLN2(23), VASP(3), WAS(7), ZYX(6)	40640738	869	198	712	322	478	52	34	209	96	0	2.40e-06	1.000	1.000
102	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	131	ACTB(7), ACTG1(5), ACTN1(5), ACTN2(21), ACTN3(7), ACTN4(5), AKT1(3), AKT2(8), AKT3(4), AMOTL1(2), ASH1L(26), CASK(4), CDC42(2), CDK4(5), CGN(8), CLDN1(5), CLDN10(5), CLDN11(4), CLDN14(5), CLDN16(7), CLDN17(5), CLDN18(7), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(1), CLDN4(10), CLDN6(8), CLDN7(2), CLDN8(3), CLDN9(1), CRB3(1), CSDA(3), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(23), CTNNA3(28), CTNNB1(11), CTTN(2), EPB41(8), EPB41L1(10), EPB41L2(18), EPB41L3(6), EXOC3(3), EXOC4(9), F11R(5), GNAI1(1), GNAI2(5), GNAI3(2), HCLS1(9), HRAS(3), IGSF5(10), INADL(39), JAM2(10), JAM3(2), KRAS(4), LLGL1(4), LLGL2(13), MAGI1(26), MAGI2(22), MAGI3(12), MLLT4(13), MPDZ(12), MPP5(1), MRAS(1), MYH1(85), MYH10(13), MYH11(26), MYH13(36), MYH14(17), MYH15(53), MYH2(77), MYH3(21), MYH4(80), MYH6(32), MYH7(43), MYH7B(25), MYH8(52), MYH9(12), MYL2(5), MYL5(1), MYL7(2), MYL9(2), MYLPF(2), NRAS(67), OCLN(4), PARD3(15), PARD6A(1), PARD6B(1), PARD6G(3), PPM1J(1), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(6), PPP2R3A(7), PPP2R3B(4), PPP2R4(2), PRKCA(10), PRKCD(4), PRKCE(6), PRKCG(13), PRKCH(10), PRKCI(8), PRKCQ(16), PRKCZ(5), PTEN(18), RAB3B(1), RHOA(1), RRAS(1), SPTAN1(7), SRC(1), SYMPK(5), TJAP1(3), TJP1(11), TJP2(8), TJP3(18), VAPA(1), YES1(5), ZAK(6)	64527617	1376	195	1254	817	897	115	68	176	117	3	0.335	1.000	1.000
103	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	28	BRAF(123), CPEB1(8), EGFR(22), ERBB2(7), ERBB4(47), ETS1(4), ETS2(8), ETV6(11), ETV7(3), FMN2(72), GRB2(2), KRAS(4), MAP2K1(10), MAPK1(4), MAPK3(1), NOTCH1(6), NOTCH2(41), NOTCH3(23), NOTCH4(54), PIWIL1(20), PIWIL2(11), PIWIL3(13), PIWIL4(4), RAF1(8), SOS1(8), SOS2(11), SPIRE1(2), SPIRE2(6)	17539175	533	194	405	173	290	24	18	167	34	0	0.000701	1.000	1.000
104	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(3), AKT2(8), AKT3(4), CBL(8), CBLB(16), CBLC(14), CCND1(1), CCND2(5), CCND3(2), CISH(3), CLCF1(1), CNTF(1), CNTFR(3), CREBBP(20), CSF2(2), CSF2RA(17), CSF2RB(17), CSF3(4), CSF3R(6), EP300(14), EPO(5), EPOR(1), GH1(3), GH2(10), GHR(25), GRB2(2), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(9), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(5), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IFNG(2), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(4), IL10(3), IL10RA(7), IL10RB(5), IL11(2), IL11RA(3), IL12A(3), IL12B(3), IL12RB1(15), IL12RB2(3), IL13(2), IL13RA1(3), IL13RA2(3), IL15(3), IL15RA(6), IL19(2), IL2(4), IL20(4), IL20RA(9), IL21(6), IL21R(17), IL22(1), IL22RA1(11), IL22RA2(1), IL23A(2), IL23R(7), IL26(3), IL28A(1), IL28B(4), IL28RA(4), IL29(1), IL2RA(4), IL2RB(7), IL2RG(3), IL3(3), IL3RA(7), IL4(1), IL4R(13), IL5(4), IL5RA(12), IL6(2), IL6R(4), IL6ST(10), IL7(5), IL7R(27), IL9(1), IL9R(5), IRF9(1), JAK1(6), JAK2(9), JAK3(6), LEP(2), LEPR(22), LIF(2), LIFR(33), MPL(7), MYC(5), OSM(5), OSMR(35), PIAS1(5), PIAS2(5), PIAS3(5), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PIM1(1), PRL(1), PRLR(29), PTPN11(9), PTPN6(3), SOCS2(2), SOCS3(2), SOCS4(3), SOCS5(5), SOCS7(4), SOS1(8), SOS2(11), SPRED1(5), SPRED2(2), SPRY1(7), SPRY2(4), SPRY3(11), SPRY4(1), STAM(4), STAM2(1), STAT1(4), STAT2(8), STAT3(10), STAT4(22), STAT5A(2), STAT5B(4), STAT6(7), TPO(40), TSLP(1), TYK2(7)	48583509	963	191	929	451	638	75	37	117	95	1	0.0199	1.000	1.000
105	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADCY9(9), ADRA1A(8), ADRA1B(3), ADRA1D(4), ADRB1(5), ADRB2(2), ANXA6(6), ARRB1(3), ARRB2(6), ATP1A4(12), ATP1B1(1), ATP1B3(1), ATP2A2(12), ATP2A3(14), ATP2B1(6), ATP2B2(24), ATP2B3(9), CACNA1A(32), CACNA1B(26), CACNA1C(43), CACNA1D(29), CACNA1E(97), CACNA1S(46), CACNB1(4), CACNB3(2), CALM1(1), CALM2(1), CALR(1), CAMK1(4), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CAMK4(10), CASQ1(8), CASQ2(4), CHRM1(5), CHRM2(18), CHRM3(19), CHRM4(6), CHRM5(4), GJA1(7), GJA4(4), GJA5(7), GJB1(1), GJB2(3), GJB3(3), GJB4(6), GJB5(6), GJB6(6), GNA11(7), GNAI2(5), GNAI3(2), GNAO1(2), GNAQ(4), GNAZ(6), GNB2(1), GNB3(7), GNB4(3), GNB5(2), GNG2(3), GNG4(2), GNG7(2), GRK4(8), GRK5(4), GRK6(3), ITPR1(29), ITPR2(17), ITPR3(6), KCNB1(31), KCNJ3(18), KCNJ5(12), MIB1(5), NME7(4), PKIA(3), PKIB(1), PKIG(1), PLCB3(4), PRKACA(3), PRKACB(4), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), PRKCD(4), PRKCE(6), PRKCG(13), PRKCH(10), PRKCQ(16), PRKCZ(5), PRKD1(3), RGS1(3), RGS11(2), RGS14(3), RGS16(2), RGS18(8), RGS20(2), RGS3(12), RGS4(2), RGS5(2), RGS6(14), RGS7(36), RGS9(10), RYR1(87), RYR2(84), RYR3(81), SFN(1), SLC8A1(27), SLC8A3(34), USP5(4), YWHAB(1), YWHAQ(3)	62094424	1357	190	1285	967	943	126	54	117	114	3	0.817	1.000	1.000
106	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(4), ACTA2(4), ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADCY9(9), ARRB1(3), ARRB2(6), ATF1(4), ATF2(5), ATF4(7), ATF5(7), ATP2A2(12), ATP2A3(14), CACNB3(2), CALCA(2), CALM1(1), CALM2(1), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CNN1(5), CNN2(2), CORIN(26), CREB3(1), CRH(3), CRHR1(6), DGKZ(7), ETS2(8), FOS(2), GABPA(1), GABPB2(8), GBA2(2), GJA1(7), GNAQ(4), GNB2(1), GNB3(7), GNB4(3), GNB5(2), GNG2(3), GNG4(2), GNG7(2), GRK4(8), GRK5(4), GRK6(3), GSTO1(2), GUCA2A(1), GUCA2B(1), GUCY1A3(29), IGFBP1(3), IGFBP2(2), IGFBP3(2), IGFBP6(2), IL1B(6), IL6(2), ITPR1(29), ITPR2(17), ITPR3(6), JUN(1), MIB1(5), MYL2(5), MYL4(5), MYLK2(10), NFKB1(7), NOS1(58), NOS3(16), OXTR(5), PDE4B(7), PDE4D(7), PKIA(3), PKIB(1), PKIG(1), PLCB3(4), PLCD1(3), PLCG1(9), PLCG2(25), PRKACA(3), PRKACB(4), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), PRKCD(4), PRKCE(6), PRKCH(10), PRKCQ(16), PRKCZ(5), PRKD1(3), RAMP1(1), RAMP2(1), RAMP3(2), RGS1(3), RGS11(2), RGS14(3), RGS16(2), RGS18(8), RGS20(2), RGS3(12), RGS4(2), RGS5(2), RGS6(14), RGS7(36), RGS9(10), RLN1(3), RYR1(87), RYR2(84), RYR3(81), SFN(1), SLC8A1(27), SP1(5), TNXB(132), USP5(4), YWHAB(1), YWHAQ(3)	58018431	1206	190	1142	717	851	101	42	114	95	3	0.0599	1.000	1.000
107	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	92	ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADCY9(9), ADRB1(5), CSNK1D(1), DRD1(8), DRD2(15), EGF(18), EGFR(22), GJA1(7), GJD2(5), GNA11(7), GNAI1(1), GNAI2(5), GNAI3(2), GNAQ(4), GNAS(19), GRB2(2), GRM1(16), GRM5(13), GUCY1A2(18), GUCY1A3(29), GUCY1B3(7), GUCY2C(32), GUCY2D(8), GUCY2F(15), HRAS(3), HTR2A(8), HTR2B(2), HTR2C(10), ITPR1(29), ITPR2(17), ITPR3(6), KRAS(4), MAP2K1(10), MAP2K2(3), MAP2K5(3), MAP3K2(6), MAPK1(4), MAPK3(1), MAPK7(4), NPR1(16), NPR2(14), NRAS(67), PDGFA(1), PDGFB(3), PDGFC(16), PDGFD(6), PDGFRA(27), PDGFRB(16), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PRKACA(3), PRKACB(4), PRKACG(8), PRKCA(10), PRKCG(13), PRKG1(12), PRKG2(13), PRKX(3), RAF1(8), SOS1(8), SOS2(11), SRC(1), TJP1(11), TUBA1A(2), TUBA1B(4), TUBA1C(2), TUBA3C(21), TUBA3D(11), TUBA3E(3), TUBA4A(6), TUBA8(3), TUBAL3(11), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(5), TUBB4(3), TUBB4Q(9), TUBB6(10), TUBB8(13)	43876921	1006	189	888	541	653	75	62	139	76	1	0.00952	1.000	1.000
108	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	37	ACTA1(4), ACTA2(4), ACTN2(21), ACTN3(7), ACTN4(5), DES(8), DMD(31), FAM48A(1), MYBPC1(19), MYBPC2(17), MYBPC3(15), MYH3(21), MYH6(32), MYH7(43), MYH8(52), MYL1(12), MYL2(5), MYL3(2), MYL4(5), MYL9(2), MYOM1(23), NEB(107), TCAP(1), TNNC2(3), TNNI1(1), TNNI2(2), TNNI3(2), TNNT1(3), TNNT2(4), TNNT3(3), TPM1(3), TPM2(3), TPM3(2), TPM4(2), TTN(1051), VIM(5)	44331174	1521	189	1416	654	1131	106	51	140	82	11	5.87e-07	1.000	1.000
109	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	144	APC(19), APC2(9), AXIN1(10), AXIN2(3), BTRC(4), CACYBP(2), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CCND1(1), CCND2(5), CCND3(2), CER1(12), CHD8(21), CHP(3), CREBBP(20), CSNK1A1(2), CSNK1A1L(5), CSNK1E(4), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), CTBP2(1), CTNNB1(11), CTNNBIP1(1), CUL1(5), CXXC4(1), DAAM1(5), DAAM2(5), DKK1(2), DKK2(14), DKK4(3), DVL2(3), DVL3(7), EP300(14), FBXW11(5), FZD1(4), FZD10(2), FZD2(5), FZD4(1), FZD5(2), FZD6(2), FZD7(4), FZD8(4), FZD9(1), GSK3B(2), JUN(1), LEF1(3), LRP5(18), LRP6(21), MAP3K7(1), MAPK10(8), MAPK8(1), MAPK9(5), MMP7(4), MYC(5), NFAT5(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NKD1(8), NKD2(5), NLK(5), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PORCN(4), PPARD(3), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(6), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PRICKLE1(9), PRICKLE2(5), PRKACA(3), PRKACB(4), PRKACG(8), PRKCA(10), PRKCG(13), PRKX(3), PSEN1(1), RAC1(17), RAC2(1), RHOA(1), ROCK1(5), ROCK2(12), RUVBL1(1), SENP2(11), SFRP1(2), SFRP2(9), SFRP4(6), SMAD2(3), SMAD3(2), SMAD4(2), SOX17(6), TBL1X(5), TBL1XR1(1), TBL1Y(7), TCF7(1), TCF7L1(3), TCF7L2(7), TP53(39), VANGL1(2), VANGL2(8), WIF1(7), WNT1(2), WNT10A(7), WNT10B(5), WNT11(4), WNT16(1), WNT2(7), WNT2B(4), WNT3(5), WNT3A(6), WNT4(2), WNT5A(5), WNT5B(5), WNT6(2), WNT7A(13), WNT7B(6), WNT8A(7), WNT8B(7), WNT9A(3), WNT9B(3)	53606927	870	186	826	406	552	69	39	117	92	1	0.0148	1.000	1.000
110	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	84	ATF2(5), BRAF(123), CHUK(2), DAXX(9), ELK1(2), FOS(2), GRB2(2), HRAS(3), IKBKB(3), JUN(1), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K5(3), MAP2K6(3), MAP2K7(4), MAP3K1(2), MAP3K10(8), MAP3K11(6), MAP3K12(3), MAP3K13(10), MAP3K14(3), MAP3K2(6), MAP3K3(6), MAP3K4(17), MAP3K5(16), MAP3K6(6), MAP3K7(1), MAP3K9(22), MAP4K1(9), MAP4K2(6), MAP4K3(8), MAP4K4(7), MAP4K5(3), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK4(15), MAPK6(6), MAPK7(4), MAPK8(1), MAPK9(5), MAPKAPK2(7), MAPKAPK3(3), MAPKAPK5(1), MEF2A(5), MEF2B(2), MEF2C(2), MEF2D(4), MKNK1(5), MKNK2(2), MYC(5), NFKB1(7), NFKBIA(2), PAK1(4), PAK2(8), RAC1(17), RAF1(8), RELA(4), RIPK1(1), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KA4(4), RPS6KA5(4), RPS6KB1(2), RPS6KB2(3), SHC1(1), SP1(5), STAT1(4), TGFB1(1), TGFB2(1), TGFB3(3), TRAF2(2)	31555937	512	184	384	196	248	42	21	163	38	0	0.0349	1.000	1.000
111	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	34	AKT1(3), AKT2(8), AKT3(4), BRAF(123), DAG1(5), DRD2(15), EGFR(22), EPHB2(29), GRB2(2), ITPKB(7), ITPR1(29), ITPR2(17), ITPR3(6), KCNJ3(18), KCNJ5(12), KCNJ9(4), MAPK1(4), PI3(6), PIK3CB(21), PITX2(4), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), RAF1(8), RGS20(2), SHC1(1), SOS1(8), SOS2(11), SRC(1), STAT3(10), TERF2IP(1)	19539910	511	184	377	203	266	32	27	151	34	1	0.00165	1.000	1.000
112	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(6), ADORA2A(2), ADORA2B(1), ADORA3(12), ADRA1A(8), ADRA1B(3), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(2), AGTR1(10), AGTR2(9), AVPR1A(4), AVPR1B(9), AVPR2(1), BDKRB1(5), BDKRB2(9), BRS3(5), C3AR1(4), CCBP2(8), CCKAR(9), CCKBR(10), CCR1(9), CCR10(2), CCR2(16), CCR3(10), CCR4(7), CCR5(7), CCR6(2), CCR7(3), CCR8(6), CCR9(5), CCRL2(5), CHML(4), CHRM1(5), CHRM2(18), CHRM3(19), CHRM4(6), CHRM5(4), CMKLR1(12), CNR1(9), CNR2(4), CX3CR1(13), CXCR3(4), CXCR4(3), DRD1(8), DRD2(15), DRD3(5), DRD4(1), DRD5(22), EDNRA(8), EDNRB(4), F2R(6), F2RL1(15), F2RL2(6), F2RL3(3), FPR1(18), FSHR(15), GALR1(5), GALR3(2), GALT(2), GHSR(8), GNB2L1(3), GPR17(1), GPR173(1), GPR174(12), GPR27(2), GPR3(2), GPR35(3), GPR37(9), GPR37L1(6), GPR4(4), GPR50(17), GPR6(6), GPR63(6), GPR77(5), GPR83(13), GPR85(5), GPR87(4), GRPR(5), HCRTR1(2), HCRTR2(26), HRH1(14), HRH2(3), HRH3(4), HTR1A(8), HTR1B(1), HTR1D(3), HTR1E(5), HTR1F(7), HTR2A(8), HTR2B(2), HTR2C(10), HTR4(9), HTR5A(16), HTR6(1), HTR7(8), LHCGR(24), LTB4R(1), MAS1(3), MC3R(7), MC4R(1), MC5R(7), MLNR(1), MTNR1A(8), MTNR1B(7), NMBR(6), NMUR1(6), NMUR2(14), NPY1R(25), NPY2R(12), NPY5R(22), NTSR1(6), NTSR2(3), OPN1SW(2), OPN3(3), OPRD1(2), OPRK1(21), OPRL1(5), OPRM1(5), OR10A5(7), OR11A1(6), OR12D3(5), OR1C1(9), OR1F1(5), OR1Q1(7), OR2H1(7), OR5V1(9), OR7A5(2), OR7C1(2), OR8B8(10), OXTR(5), P2RY1(4), P2RY10(6), P2RY12(3), P2RY13(4), P2RY14(8), P2RY2(8), P2RY6(1), PPYR1(12), PTAFR(2), PTGDR(9), PTGER2(6), PTGER4(1), PTGFR(20), PTGIR(5), RGR(5), RHO(2), RRH(1), SSTR1(10), SSTR2(5), SSTR3(11), SSTR4(3), SUCNR1(9), TBXA2R(4), TRHR(19)	40407007	1101	183	1042	822	750	110	36	128	77	0	0.00224	1.000	1.000
113	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	130	ALCAM(5), CADM1(3), CADM3(17), CD2(23), CD22(22), CD226(6), CD274(1), CD276(6), CD28(1), CD34(4), CD4(6), CD40(4), CD40LG(2), CD58(1), CD6(7), CD80(4), CD86(19), CD8A(2), CD8B(7), CD99(1), CDH1(5), CDH15(9), CDH2(12), CDH4(28), CDH5(9), CLDN1(5), CLDN10(5), CLDN11(4), CLDN14(5), CLDN16(7), CLDN17(5), CLDN18(7), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(1), CLDN4(10), CLDN6(8), CLDN7(2), CLDN8(3), CLDN9(1), CNTN1(22), CNTN2(14), CNTNAP1(11), CNTNAP2(76), CTLA4(2), ESAM(3), F11R(5), GLG1(5), HLA-A(6), HLA-B(5), HLA-C(1), HLA-DMA(4), HLA-DMB(7), HLA-DOA(4), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(7), HLA-DQB1(5), HLA-DRA(11), HLA-DRB1(3), HLA-DRB5(1), HLA-E(1), HLA-F(6), HLA-G(3), ICAM1(2), ICAM2(4), ICAM3(2), ICOS(3), ICOSLG(2), ITGA4(36), ITGA6(8), ITGA8(36), ITGA9(13), ITGAL(24), ITGAM(21), ITGAV(9), ITGB1(4), ITGB2(13), ITGB7(6), ITGB8(17), JAM2(10), JAM3(2), L1CAM(8), MADCAM1(1), MAG(11), MPZ(4), MPZL1(1), NCAM1(10), NCAM2(8), NEGR1(6), NEO1(12), NFASC(39), NLGN1(10), NLGN2(5), NLGN3(6), NRCAM(8), NRXN1(44), NRXN2(15), NRXN3(27), OCLN(4), PDCD1(3), PDCD1LG2(3), PTPRC(30), PTPRF(27), PTPRM(7), PVR(3), PVRL1(4), PVRL2(5), PVRL3(5), SDC1(3), SDC2(2), SDC3(6), SDC4(3), SELE(34), SELL(8), SELP(30), SELPLG(8), SIGLEC1(24), SPN(5), VCAM1(16), VCAN(34)	48830368	1182	183	1129	556	827	89	44	130	92	0	2.86e-05	1.000	1.000
114	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	142	ADA(2), ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADCY9(9), ADK(4), ADSL(6), ADSS(2), ADSSL1(8), AK1(1), AK2(3), AK5(6), AK7(22), ALLC(7), AMPD1(28), AMPD2(5), AMPD3(22), APRT(3), ATIC(5), CANT1(9), DGUOK(4), ENPP1(11), ENPP3(14), ENTPD1(10), ENTPD2(4), ENTPD3(6), ENTPD4(4), ENTPD5(1), ENTPD6(4), ENTPD8(2), FHIT(2), GART(9), GDA(12), GMPR2(1), GMPS(4), GUCY1A2(18), GUCY1A3(29), GUCY1B3(7), GUCY2C(32), GUCY2D(8), GUCY2F(15), GUK1(2), IMPDH1(2), IMPDH2(1), NME6(2), NME7(4), NPR1(16), NPR2(14), NT5C1A(3), NT5C1B(22), NT5C2(3), NT5C3(2), NT5E(4), NT5M(2), NUDT5(2), NUDT9(2), PAICS(1), PAPSS1(3), PAPSS2(5), PDE10A(12), PDE11A(17), PDE1A(35), PDE1C(41), PDE2A(13), PDE3B(6), PDE4A(9), PDE4B(7), PDE4C(16), PDE4D(7), PDE5A(8), PDE6D(2), PDE6G(2), PDE7A(1), PDE7B(16), PDE8A(2), PDE8B(21), PDE9A(9), PFAS(8), PKLR(11), PKM2(5), PNPT1(1), POLA1(2), POLA2(8), POLD1(6), POLD2(2), POLD3(4), POLE(15), POLE2(3), POLR1A(11), POLR1B(8), POLR1C(1), POLR2A(11), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(4), POLR3B(17), POLR3G(1), POLR3GL(1), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(15), PRPS1(2), PRPS1L1(13), PRPS2(3), PRUNE(1), RRM1(3), RRM2(2), RRM2B(2), XDH(50)	54586382	1006	181	962	503	691	81	48	102	84	0	0.00223	1.000	1.000
115	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	92	ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADCY9(9), AKAP1(9), AKAP10(3), AKAP11(12), AKAP12(4), AKAP3(16), AKAP4(16), AKAP6(35), AKAP7(3), AKAP8(6), AKAP9(27), ARHGEF1(1), CALM1(1), CALM2(1), CHMP1B(1), GNA11(7), GNA12(3), GNA13(1), GNA14(5), GNA15(5), GNAI2(5), GNAI3(2), GNAL(2), GNAO1(2), GNAQ(4), GNAZ(6), GNB2(1), GNB3(7), GNB5(2), GNG4(2), GNG7(2), GNGT2(4), HRAS(3), ITPR1(29), KCNJ3(18), KRAS(4), NRAS(67), PDE1A(35), PDE1B(12), PDE1C(41), PDE4A(9), PDE4B(7), PDE4C(16), PDE4D(7), PDE7A(1), PDE7B(16), PDE8A(2), PDE8B(21), PLCB3(4), PPP3CA(5), PPP3CC(2), PRKACA(3), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), PRKCD(4), PRKCE(6), PRKCG(13), PRKCH(10), PRKCI(8), PRKCQ(16), PRKCZ(5), PRKD1(3), PRKD3(4), RHOA(1), RRAS(1), SLC9A1(3), USP5(4)	39008154	733	180	646	401	463	55	54	111	50	0	0.258	1.000	1.000
116	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	66	A2M(22), BDKRB1(5), BDKRB2(9), C1QA(4), C1QB(3), C1QC(7), C1R(13), C1S(15), C2(14), C3(46), C3AR1(4), C4BPA(16), C4BPB(6), C5(14), C5AR1(9), C6(56), C7(43), C8A(37), C8B(43), C8G(1), C9(19), CD55(4), CD59(1), CFB(32), CFH(43), CFI(13), CPB2(1), CR1(53), CR2(32), F10(8), F11(12), F12(1), F13A1(26), F13B(23), F2(9), F2R(6), F5(30), F7(7), F8(43), F9(12), FGA(38), FGB(10), FGG(7), KLKB1(23), KNG1(11), MASP1(8), MASP2(9), MBL2(12), PLAT(3), PLAU(3), PLAUR(2), PLG(30), PROC(8), PROS1(13), SERPINA1(7), SERPINA5(9), SERPINC1(7), SERPIND1(4), SERPINE1(5), SERPINF2(6), SERPING1(12), TFPI(8), THBD(3), VWF(49)	30124361	1029	180	962	433	729	77	42	99	80	2	8.26e-05	1.000	1.000
117	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	95	ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADCY9(9), ATF4(7), CACNA1C(43), CACNA1D(29), CACNA1F(20), CACNA1S(46), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CDC42(2), CGA(1), EGFR(22), ELK1(2), FSHB(4), GNA11(7), GNAQ(4), GNAS(19), GNRH2(2), GNRHR(2), GRB2(2), HBEGF(1), HRAS(3), ITPR1(29), ITPR2(17), ITPR3(6), JUN(1), KRAS(4), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K6(3), MAP2K7(4), MAP3K1(2), MAP3K2(6), MAP3K3(6), MAP3K4(17), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK7(4), MAPK8(1), MAPK9(5), MMP14(2), MMP2(7), NRAS(67), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PLD1(11), PLD2(5), PRKACA(3), PRKACB(4), PRKACG(8), PRKCA(10), PRKCD(4), PRKX(3), PTK2B(10), RAF1(8), SOS1(8), SOS2(11), SRC(1)	42051633	870	179	765	518	543	74	59	123	70	1	0.374	1.000	1.000
118	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	99	ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADCY9(9), ASIP(2), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CREB3(1), CREB3L1(4), CREB3L2(7), CREB3L3(9), CREB3L4(5), CREBBP(20), CTNNB1(11), DCT(3), DVL2(3), DVL3(7), EDN1(8), EDNRB(4), EP300(14), FZD1(4), FZD10(2), FZD2(5), FZD4(1), FZD5(2), FZD6(2), FZD7(4), FZD8(4), FZD9(1), GNAI1(1), GNAI2(5), GNAI3(2), GNAO1(2), GNAQ(4), GNAS(19), GSK3B(2), HRAS(3), KIT(9), KITLG(8), KRAS(4), LEF1(3), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), MITF(4), NRAS(67), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), POMC(3), PRKACA(3), PRKACB(4), PRKACG(8), PRKCA(10), PRKCG(13), PRKX(3), RAF1(8), TCF7(1), TCF7L1(3), TCF7L2(7), TYR(8), TYRP1(8), WNT1(2), WNT10A(7), WNT10B(5), WNT11(4), WNT16(1), WNT2(7), WNT2B(4), WNT3(5), WNT3A(6), WNT4(2), WNT5A(5), WNT5B(5), WNT6(2), WNT7A(13), WNT7B(6), WNT8A(7), WNT8B(7), WNT9A(3), WNT9B(3)	36024624	729	178	632	388	436	58	54	115	65	1	0.0656	1.000	1.000
119	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	110	ABL1(12), ANAPC1(16), ANAPC10(1), ANAPC2(4), ANAPC4(4), ANAPC5(6), ANAPC7(6), ATM(12), ATR(20), BUB1(3), BUB1B(9), CCNA1(13), CCNB2(3), CCNB3(28), CCND1(1), CCND2(5), CCND3(2), CCNE1(4), CCNE2(12), CCNH(2), CDC14A(4), CDC14B(1), CDC16(1), CDC20(1), CDC23(3), CDC25A(8), CDC25B(4), CDC25C(4), CDC27(13), CDC6(1), CDC7(2), CDK4(5), CDK6(2), CDKN1A(4), CDKN1B(1), CDKN2A(34), CDKN2C(1), CHEK1(2), CHEK2(3), CREBBP(20), CUL1(5), DBF4(5), E2F1(5), E2F2(4), E2F3(5), EP300(14), ESPL1(14), FZR1(6), GADD45B(2), GSK3B(2), HDAC1(1), HDAC2(1), MAD1L1(5), MAD2L1(1), MAD2L2(1), MCM2(10), MCM3(10), MCM4(5), MCM5(4), MCM6(4), MDM2(3), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), PKMYT1(3), PLK1(3), PRKDC(19), PTTG1(1), PTTG2(5), RB1(8), RBL1(10), RBL2(4), SFN(1), SKP2(2), SMAD2(3), SMAD3(2), SMAD4(2), SMC1A(3), SMC1B(20), TFDP1(2), TGFB1(1), TGFB2(1), TGFB3(3), TP53(39), WEE1(2), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3)	45656226	539	177	499	181	284	40	38	93	82	2	4.27e-05	1.000	1.000
120	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	44	AKT1(3), AKT2(8), AKT3(4), BRAF(123), CAB39(1), EIF4B(4), EIF4EBP1(1), FIGF(4), HIF1A(5), IGF1(11), MAPK1(4), MAPK3(1), PDPK1(4), PGF(1), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PRKAA1(1), PRKAA2(24), RHEB(1), RICTOR(10), RPS6(1), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KA6(15), RPS6KB1(2), RPS6KB2(3), STK11(3), TSC1(5), TSC2(11), ULK1(7), ULK2(6), ULK3(1), VEGFA(5), VEGFB(1), VEGFC(19)	17601437	387	175	265	115	170	19	16	150	30	2	0.000189	1.000	1.000
121	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	80	AGL(17), AMY2A(5), AMY2B(10), ASCC3(10), ATP13A2(9), DDX18(4), DDX19A(1), DDX23(5), DDX4(11), DDX41(6), DDX47(1), DDX50(4), DDX51(5), DDX52(3), DDX54(2), DDX55(3), DDX56(3), DHX58(4), ENPP1(11), ENPP3(14), ENTPD7(2), EP400(22), ERCC2(2), ERCC3(4), G6PC(5), G6PC2(4), GAA(7), GANC(5), GBA(3), GBA3(14), GBE1(8), GCK(17), GPI(3), GUSB(3), GYS1(3), GYS2(20), HK1(3), HK2(12), HK3(13), IFIH1(13), MGAM(133), MOV10L1(26), NUDT5(2), NUDT8(1), PGM1(4), PGM3(1), PYGB(2), PYGL(7), PYGM(10), RAD54B(6), RUVBL2(4), SETX(17), SI(71), SKIV2L2(4), SMARCA2(11), SMARCA5(5), TREH(3), UGDH(1), UGP2(1), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(8), UGT1A9(10), UGT2A1(18), UGT2A3(24), UGT2B10(36), UGT2B11(19), UGT2B15(25), UGT2B28(24), UGT2B4(31), UGT2B7(17), UXS1(4)	41015142	879	174	822	395	603	73	37	83	82	1	0.00140	1.000	1.000
122	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	92	AKT1(3), AKT2(8), AKT3(4), BCL10(3), CARD11(32), CBL(8), CBLB(16), CBLC(14), CD247(3), CD28(1), CD3D(5), CD3E(2), CD3G(1), CD4(6), CD40LG(2), CD8A(2), CD8B(7), CDC42(2), CDK4(5), CHP(3), CHUK(2), CSF2(2), CTLA4(2), FOS(2), FYN(6), GRAP2(4), GRB2(2), HRAS(3), ICOS(3), IFNG(2), IKBKB(3), IL10(3), IL2(4), IL4(1), IL5(4), ITK(20), JUN(1), KRAS(4), LAT(1), LCK(12), LCP2(9), MALT1(7), MAP3K14(3), NCK1(1), NCK2(4), NFAT5(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NRAS(67), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PDCD1(3), PDK1(2), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PRKCQ(16), PTPN6(3), PTPRC(30), RASGRP1(7), RHOA(1), SOS1(8), SOS2(11), TEC(10), TNF(1), VAV1(15), VAV2(3), VAV3(9), ZAP70(8)	33870226	679	174	596	283	395	47	51	132	53	1	0.00679	1.000	1.000
123	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	42	AKT1(3), ATF1(4), BRAF(123), CAMP(1), CREB3(1), CREB5(9), CREBBP(20), CRKL(2), DAG1(5), EGR1(4), EGR2(4), EGR3(2), EGR4(5), ELK1(2), FRS2(4), GNAQ(4), JUN(1), MAP1B(21), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK3(1), MAPK8(1), MAPK8IP1(4), MAPK8IP2(7), MAPK8IP3(8), MAPK9(5), NTRK1(15), OPN1LW(4), PIK3C2G(43), PIK3CA(8), PIK3CD(7), PIK3R1(3), PTPN11(9), RPS6KA3(2), SHC1(1), SRC(1), TERF2IP(1), TH(9)	17075815	364	174	248	122	175	18	13	133	24	1	0.00414	1.000	1.000
124	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	110	ACTN1(5), ACTN2(21), ACTN3(7), ACTN4(5), ARHGAP5(11), BCAR1(4), CD99(1), CDC42(2), CDH5(9), CLDN1(5), CLDN10(5), CLDN11(4), CLDN14(5), CLDN16(7), CLDN17(5), CLDN18(7), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(1), CLDN4(10), CLDN6(8), CLDN7(2), CLDN8(3), CLDN9(1), CTNNA1(2), CTNNA2(23), CTNNA3(28), CTNNB1(11), CTNND1(9), CXCL12(2), CXCR4(3), CYBA(1), CYBB(7), ESAM(3), EZR(1), F11R(5), GNAI1(1), GNAI2(5), GNAI3(2), GRLF1(12), ICAM1(2), ITGA4(36), ITGAL(24), ITGAM(21), ITGB1(4), ITGB2(13), ITK(20), JAM2(10), JAM3(2), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MLLT4(13), MMP2(7), MMP9(7), MSN(1), MYL2(5), MYL5(1), MYL7(2), MYL9(2), MYLPF(2), NCF1(1), NCF2(7), NCF4(4), NOX1(11), NOX3(6), OCLN(4), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PLCG1(9), PLCG2(25), PRKCA(10), PRKCG(13), PTK2(8), PTK2B(10), PTPN11(9), PXN(3), RAC1(17), RAC2(1), RAP1A(2), RAP1B(1), RAPGEF3(12), RAPGEF4(12), RASSF5(5), RHOA(1), RHOH(5), ROCK1(5), ROCK2(12), SIPA1(8), THY1(1), TXK(9), VASP(3), VAV1(15), VAV2(3), VAV3(9), VCAM1(16), VCL(7)	41240476	784	173	740	382	525	53	25	105	73	3	0.00254	1.000	1.000
125	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	69	ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), AKR1C1(2), AKR1C2(4), AKR1C3(9), AKR1C4(9), ALDH1A3(2), ALDH3A1(5), ALDH3B1(2), ALDH3B2(7), CYP1A1(10), CYP1A2(10), CYP1B1(2), CYP2B6(16), CYP2C18(26), CYP2C19(35), CYP2C8(30), CYP2C9(35), CYP2E1(13), CYP2F1(11), CYP2S1(9), CYP3A4(19), CYP3A43(15), CYP3A5(10), CYP3A7(18), DHDH(5), EPHX1(2), GSTA1(5), GSTA2(2), GSTA3(1), GSTA5(3), GSTK1(2), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTP1(2), GSTT1(1), MGST1(2), MGST2(2), MGST3(1), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(8), UGT1A9(10), UGT2A1(18), UGT2A3(24), UGT2B10(36), UGT2B11(19), UGT2B15(25), UGT2B28(24), UGT2B4(31), UGT2B7(17)	19104501	729	172	665	306	535	51	38	48	56	1	3.71e-09	1.000	1.000
126	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	83	ANPEP(17), CD14(5), CD19(7), CD1A(11), CD1B(12), CD1C(23), CD1D(8), CD1E(19), CD2(23), CD22(22), CD33(17), CD34(4), CD36(4), CD37(3), CD38(4), CD3D(5), CD3E(2), CD3G(1), CD4(6), CD44(5), CD5(6), CD55(4), CD59(1), CD8A(2), CD8B(7), CR1(53), CR2(32), CSF1(10), CSF1R(12), CSF2(2), CSF2RA(17), CSF3(4), CSF3R(6), DNTT(9), EPO(5), EPOR(1), FCER2(3), FCGR1A(6), FLT3(31), FLT3LG(2), GP5(4), GP9(6), GYPA(7), HLA-DRA(11), HLA-DRB1(3), HLA-DRB5(1), IL11(2), IL11RA(3), IL1A(4), IL1B(6), IL1R1(11), IL1R2(7), IL2RA(4), IL3(3), IL3RA(7), IL4(1), IL4R(13), IL5(4), IL5RA(12), IL6(2), IL6R(4), IL7(5), IL7R(27), IL9R(5), ITGA1(18), ITGA2(11), ITGA2B(10), ITGA3(7), ITGA4(36), ITGA5(20), ITGA6(8), ITGAM(21), ITGB3(11), KIT(9), KITLG(8), MME(19), MS4A1(7), TFRC(4), THPO(7), TNF(1), TPO(40)	27135790	800	171	754	373	582	44	28	60	86	0	0.00134	1.000	1.000
127	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	73	CALM1(1), CALM2(1), CALML3(6), CDS1(9), CDS2(4), DGKA(3), DGKB(22), DGKD(9), DGKE(6), DGKG(16), DGKH(8), DGKI(23), DGKQ(6), DGKZ(7), IMPA1(1), IMPA2(2), INPP1(2), INPP4A(5), INPP4B(2), INPP5A(4), INPP5B(6), INPP5D(31), INPPL1(15), ITPK1(6), ITPKB(7), ITPR1(29), ITPR2(17), ITPR3(6), OCRL(4), PI4KA(18), PI4KB(4), PIK3C2A(6), PIK3C2B(13), PIK3C2G(43), PIK3C3(3), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PIP4K2A(5), PIP4K2B(3), PIP4K2C(3), PIP5K1A(6), PIP5K1B(18), PIP5K1C(8), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PLCD1(3), PLCD3(3), PLCD4(2), PLCE1(48), PLCG1(9), PLCG2(25), PLCZ1(20), PRKCA(10), PRKCG(13), PTEN(18), SYNJ1(20), SYNJ2(15)	41324218	787	169	733	367	537	41	32	97	78	2	0.000853	1.000	1.000
128	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	34	AKT1(3), APC(19), AR(7), BRAF(123), CAMP(1), CCL15(3), CCL16(1), DAG1(5), EGFR(22), GNA11(7), GNA15(5), GNAI1(1), GNAQ(4), ITPKB(7), ITPR1(29), ITPR2(17), ITPR3(6), KCNJ3(18), KCNJ5(12), KCNJ9(4), MAPK1(4), MAPK10(8), MAPK14(5), PHKA2(7), PIK3CA(8), PIK3CD(7), PIK3R1(3), PITX2(4), PTX3(1), RAF1(8), SRC(1)	17737330	350	169	236	140	152	20	18	131	28	1	0.0787	1.000	1.000
129	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	62	AKT1(3), AKT2(8), AKT3(4), BCL10(3), BLNK(12), BTK(15), CARD11(32), CD19(7), CD22(22), CD72(4), CD79A(2), CD79B(1), CD81(2), CHP(3), CHUK(2), CR2(32), FCGR2B(3), FOS(2), GSK3B(2), HRAS(3), IKBKB(3), INPP5D(31), JUN(1), KRAS(4), LILRB3(6), LYN(6), MALT1(7), NFAT5(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NRAS(67), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PLCG2(25), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PTPN6(3), RAC1(17), RAC2(1), RASGRP3(13), SYK(14), VAV1(15), VAV2(3), VAV3(9)	24892274	555	166	474	199	316	29	49	110	50	1	5.40e-06	1.000	1.000
130	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	74	AKT1(3), AKT2(8), AKT3(4), BTK(15), CSF2(2), FCER1A(12), FCER1G(1), FYN(6), GAB2(4), GRB2(2), HRAS(3), IL13(2), IL3(3), IL4(1), IL5(4), INPP5D(31), KRAS(4), LAT(1), LCP2(9), LYN(6), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K6(3), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK8(1), MAPK9(5), MS4A2(10), NRAS(67), PDK1(2), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PLCG1(9), PLCG2(25), PRKCA(10), PRKCD(4), PRKCE(6), RAC1(17), RAC2(1), RAF1(8), SOS1(8), SOS2(11), SYK(14), TNF(1), VAV1(15), VAV2(3), VAV3(9)	24101050	542	166	454	196	307	30	42	114	48	1	1.38e-05	1.000	1.000
131	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	90	AKT1(3), AKT3(4), BCAR1(4), CAPN1(4), CAPN10(7), CAPN11(9), CAPN2(6), CAPN3(9), CAPN5(4), CAPN6(13), CAPN7(1), CAPN9(12), CAPNS1(1), CAV1(1), CDC42(2), CRK(2), CSK(1), DOCK1(15), FYN(6), GIT2(8), GRB2(2), ITGA10(7), ITGA11(16), ITGA2(11), ITGA2B(10), ITGA3(7), ITGA4(36), ITGA5(20), ITGA6(8), ITGA7(23), ITGA8(36), ITGA9(13), ITGAD(24), ITGAE(16), ITGAL(24), ITGAM(21), ITGAV(9), ITGAX(18), ITGB1(4), ITGB2(13), ITGB3(11), ITGB4(20), ITGB5(6), ITGB6(11), ITGB7(6), ITGB8(17), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K6(3), MAPK10(8), MAPK12(1), MAPK4(15), MAPK6(6), MAPK7(4), MYLK2(10), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PDPK1(4), PIK3R2(5), PTK2(8), PXN(3), RAC1(17), RAC2(1), RAP1B(1), RAPGEF1(10), RHO(2), ROCK1(5), ROCK2(12), SDCCAG8(3), SEPP1(1), SHC1(1), SHC3(11), SORBS1(13), SOS1(8), SRC(1), TLN1(12), TNS1(9), VASP(3), VAV2(3), VAV3(9), VCL(7), ZYX(6)	44347329	752	166	722	337	512	53	26	96	64	1	0.000192	1.000	1.000
132	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(11), ABCA10(21), ABCA12(59), ABCA13(60), ABCA2(9), ABCA3(17), ABCA4(49), ABCA5(8), ABCA6(25), ABCA7(11), ABCA8(30), ABCA9(18), ABCB1(35), ABCB10(5), ABCB11(45), ABCB4(17), ABCB5(36), ABCB6(2), ABCB7(6), ABCB8(3), ABCB9(6), ABCC1(12), ABCC10(12), ABCC11(17), ABCC12(23), ABCC2(9), ABCC3(25), ABCC4(11), ABCC5(8), ABCC6(24), ABCC8(37), ABCC9(56), ABCD2(17), ABCD3(9), ABCD4(1), ABCG1(9), ABCG2(6), ABCG4(6), ABCG5(6), ABCG8(15), CFTR(44), TAP1(1), TAP2(13)	39346443	834	165	795	484	561	68	29	91	85	0	0.0301	1.000	1.000
133	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	98	AKT1(3), AKT2(8), AKT3(4), CASP8(8), CD14(5), CD40(4), CD80(4), CD86(19), CHUK(2), CXCL10(3), CXCL11(1), CXCL9(2), FOS(2), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(9), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(5), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IKBKB(3), IKBKE(9), IL12A(3), IL12B(3), IL1B(6), IL6(2), IL8(1), IRAK1(4), IRAK4(3), IRF3(3), IRF5(4), IRF7(7), JUN(1), LBP(8), LY96(4), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K6(3), MAP2K7(4), MAP3K7(1), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK8(1), MAPK9(5), MYD88(3), NFKB1(7), NFKB2(4), NFKBIA(2), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), RAC1(17), RELA(4), RIPK1(1), SPP1(7), STAT1(4), TBK1(5), TICAM1(9), TIRAP(1), TLR1(10), TLR2(15), TLR3(9), TLR4(31), TLR5(18), TLR6(5), TLR7(15), TLR8(8), TLR9(14), TNF(1), TOLLIP(1), TRAF3(5), TRAF6(4)	29902530	528	164	501	235	339	32	25	83	48	1	0.00181	1.000	1.000
134	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	82	ABL1(12), ATM(12), BUB1(3), BUB1B(9), CCNA1(13), CCNB2(3), CCNB3(28), CCND2(5), CCND3(2), CCNE1(4), CCNE2(12), CCNH(2), CDAN1(5), CDC14A(4), CDC14B(1), CDC20(1), CDC25A(8), CDC25B(4), CDC25C(4), CDC6(1), CDC7(2), CDH1(5), CDK4(5), CDKN1A(4), CDKN2A(34), CHEK1(2), CHEK2(3), DTX4(4), E2F1(5), E2F2(4), E2F3(5), E2F4(1), E2F5(1), EP300(14), ESPL1(14), GSK3B(2), HDAC1(1), HDAC2(1), HDAC3(5), HDAC4(10), HDAC5(6), HDAC6(2), HDAC8(3), MAD1L1(5), MAD2L1(1), MAD2L2(1), MCM2(10), MCM3(10), MCM4(5), MCM5(4), MCM6(4), MDM2(3), MPEG1(6), MPL(7), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), PLK1(3), PRKDC(19), PTPRA(7), PTTG1(1), PTTG2(5), RB1(8), RBL1(10), SKP2(2), SMAD4(2), TBC1D8(8), TFDP1(2), TGFB1(1), TP53(39), WEE1(2)	36699195	446	163	413	160	247	37	23	70	67	2	0.000122	1.000	1.000
135	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	69	AKT1(3), AKT2(8), AKT3(4), CASP9(3), CDC42(2), CHP(3), HRAS(3), KDR(42), KRAS(4), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPKAPK2(7), MAPKAPK3(3), NFAT5(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NOS3(16), NRAS(67), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PLCG1(9), PLCG2(25), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PRKCA(10), PRKCG(13), PTGS2(10), PTK2(8), PXN(3), RAC1(17), RAC2(1), RAF1(8), SH2D2A(3), SHC2(7), SPHK1(1), SPHK2(7), SRC(1), VEGFA(5)	24071138	533	163	446	200	306	24	37	117	48	1	6.81e-05	1.000	1.000
136	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(6), ALG1(2), ALG10(4), ALG10B(4), ALG12(1), ALG13(8), ALG14(2), ALG2(4), ALG3(4), ALG6(2), ALG8(6), ALG9(5), B3GNT1(2), B3GNT2(2), B3GNT7(4), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), B4GALT5(2), C1GALT1(6), C1GALT1C1(2), CHPF(3), CHST1(9), CHST11(5), CHST12(4), CHST13(3), CHST14(3), CHST2(4), CHST3(1), CHST4(9), CHST6(4), CHSY1(8), DAD1(1), DDOST(2), DPAGT1(2), EXT1(2), EXT2(6), EXTL1(2), EXTL3(10), FUT11(3), FUT8(8), GALNT1(4), GALNT10(6), GALNT11(2), GALNT12(8), GALNT13(25), GALNT14(27), GALNT2(6), GALNT3(3), GALNT4(4), GALNT5(9), GALNT6(15), GALNT7(5), GALNT8(23), GALNT9(5), GALNTL1(4), GALNTL2(19), GALNTL4(6), GALNTL5(14), GANAB(5), GCNT1(6), GCNT3(5), GCNT4(4), HS2ST1(1), HS3ST1(10), HS3ST2(7), HS3ST3A1(4), HS3ST3B1(2), HS3ST5(8), HS6ST1(3), HS6ST2(2), HS6ST3(12), MAN1A1(15), MAN1A2(4), MAN1B1(4), MAN1C1(7), MAN2A1(10), MGAT1(3), MGAT2(2), MGAT3(10), MGAT4A(8), MGAT4B(1), MGAT5(4), MGAT5B(9), NDST1(4), NDST2(2), NDST3(23), NDST4(45), OGT(10), RPN2(2), ST3GAL1(6), ST3GAL2(1), ST3GAL3(1), ST3GAL4(1), ST6GAL1(5), ST6GALNAC1(5), STT3B(5), WBSCR17(37), XYLT1(10), XYLT2(3)	36482472	655	161	628	349	444	51	27	70	63	0	0.0812	1.000	1.000
137	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	110	ADA(2), ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADK(4), ADSL(6), ADSS(2), AK1(1), AK2(3), AK5(6), ALLC(7), AMPD1(28), AMPD2(5), AMPD3(22), APRT(3), ATIC(5), ATP1B1(1), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(6), ATP5G2(1), ATP5H(1), ATP5J(2), CANT1(9), DGUOK(4), ENPP1(11), ENPP3(14), ENTPD1(10), ENTPD2(4), FHIT(2), GART(9), GDA(12), GMPS(4), GUCY1A2(18), GUCY1A3(29), GUCY1B3(7), GUCY2C(32), GUCY2D(8), GUCY2F(15), GUK1(2), IMPDH1(2), IMPDH2(1), NPR1(16), NPR2(14), NT5E(4), NT5M(2), PAICS(1), PAPSS1(3), PAPSS2(5), PDE1A(35), PDE4A(9), PDE4B(7), PDE4C(16), PDE4D(7), PDE5A(8), PDE6B(13), PDE6C(23), PDE6G(2), PDE7B(16), PDE8A(2), PDE9A(9), PFAS(8), PKLR(11), PKM2(5), POLD1(6), POLD2(2), POLE(15), POLG(8), POLL(7), POLQ(23), POLR1B(8), POLR2A(11), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(2), PRPS1(2), PRPS1L1(13), PRPS2(3), PRUNE(1), RRM1(3), RRM2(2)	42704099	762	161	721	390	530	62	26	74	70	0	0.00578	1.000	1.000
138	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	41	AGL(17), AMY2A(5), AMY2B(10), ENPP1(11), ENPP3(14), G6PC(5), GAA(7), GANAB(5), GBA3(14), GBE1(8), GCK(17), GPI(3), GUSB(3), GYS1(3), GYS2(20), HK1(3), HK2(12), HK3(13), MGAM(133), PGM1(4), PGM3(1), PYGB(2), PYGL(7), PYGM(10), SI(71), UCHL1(4), UCHL3(2), UGDH(1), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(8), UGT1A9(10), UGT2B15(25), UGT2B4(31), UXS1(4)	18938008	546	160	507	237	381	56	23	44	41	1	0.000730	1.000	1.000
139	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	75	ACP1(3), ACTB(7), ACTG1(5), ACTN1(5), ACTN2(21), ACTN3(7), ACTN4(5), ACVR1B(3), ACVR1C(9), BAIAP2(5), CDC42(2), CDH1(5), CREBBP(20), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(23), CTNNA3(28), CTNNB1(11), CTNND1(9), EGFR(22), EP300(14), ERBB2(7), FARP2(5), FER(3), FGFR1(11), FYN(6), IGF1R(10), INSR(20), IQGAP1(10), LEF1(3), LMO7(26), MAP3K7(1), MAPK1(4), MAPK3(1), MET(19), MLLT4(13), NLK(5), PARD3(15), PTPN1(4), PTPN6(3), PTPRB(79), PTPRF(27), PTPRJ(8), PTPRM(7), PVRL1(4), PVRL2(5), PVRL3(5), PVRL4(7), RAC1(17), RAC2(1), RHOA(1), SMAD2(3), SMAD3(2), SMAD4(2), SNAI1(2), SNAI2(4), SORBS1(13), SRC(1), SSX2IP(5), TCF7(1), TCF7L1(3), TCF7L2(7), TGFBR2(8), TJP1(11), VCL(7), WAS(7), WASF1(4), WASF2(4), WASF3(12), WASL(5), YES1(5)	40168883	642	159	606	309	432	46	25	70	66	3	0.117	1.000	1.000
140	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(26), ASH2L(3), CARM1(6), CTCFL(20), DOT1L(8), EED(3), EHMT1(7), EHMT2(9), EZH1(5), EZH2(10), FBXO11(6), HCFC1(15), JMJD4(4), JMJD6(1), KDM6A(3), MEN1(2), MLL(39), MLL2(47), MLL3(61), MLL4(34), MLL5(12), NSD1(16), OGT(10), PAXIP1(3), PPP1CA(1), PPP1CB(5), PPP1CC(2), PRDM2(13), PRDM7(6), PRDM9(47), PRMT1(1), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), RBBP5(5), SATB1(14), SETD1A(23), SETD2(14), SETD7(2), SETD8(1), SETDB1(10), SETDB2(4), SETMAR(4), SMYD3(2), STK38(4), SUV39H1(1), SUV39H2(1), SUV420H1(7), SUV420H2(1), SUZ12(2), WHSC1(9), WHSC1L1(6)	39478641	552	157	534	195	355	56	21	70	50	0	0.00190	1.000	1.000
141	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(2), ACVR1B(3), ACVRL1(9), AKT1(3), AURKB(2), BMPR1A(2), BMPR2(5), BUB1(3), CDKL1(5), CDKL2(2), CDS1(9), CDS2(4), CLK1(4), CLK2(6), COL4A3BP(3), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), DGKA(3), DGKB(22), DGKD(9), DGKE(6), DGKG(16), DGKH(8), DGKQ(6), DGKZ(7), IMPA1(1), INPP1(2), INPP4A(5), INPP4B(2), INPP5A(4), INPPL1(15), ITPKB(7), MAP3K10(8), MOS(5), NEK1(8), NEK3(2), OCRL(4), PAK4(4), PIK3C2A(6), PIK3C2B(13), PIK3C2G(43), PIK3CA(8), PIK3CB(21), PIK3CG(24), PIM2(4), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PLCD1(3), PLCG1(9), PLCG2(25), PLK3(2), PRKACA(3), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), PRKCD(4), PRKCE(6), PRKCG(13), PRKCH(10), PRKCQ(16), PRKCZ(5), PRKD1(3), PRKG1(12), RAF1(8), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KA4(4), RPS6KB1(2), STK11(3)	37505174	633	155	595	346	434	33	24	78	63	1	0.598	1.000	1.000
142	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(10), AGTR2(9), ATP8A1(22), AVPR1A(4), AVPR1B(9), AVPR2(1), BDKRB1(5), BDKRB2(9), BRS3(5), C3AR1(4), CCKAR(9), CCKBR(10), CCR1(9), CCR10(2), CCR2(16), CCR3(10), CCR4(7), CCR5(7), CCR6(2), CCR7(3), CCR8(6), CX3CR1(13), CXCR3(4), CXCR4(3), CXCR6(4), EDNRA(8), EDNRB(4), FPR1(18), FSHR(15), GALR1(5), GALR3(2), GALT(2), GHSR(8), GNB2L1(3), GNRHR(2), GPR77(5), GRPR(5), LHCGR(24), MC2R(5), MC3R(7), MC4R(1), MC5R(7), NMBR(6), NPY1R(25), NPY2R(12), NPY5R(22), NTSR1(6), NTSR2(3), OPRD1(2), OPRK1(21), OPRL1(5), OPRM1(5), OXTR(5), PPYR1(12), SSTR1(10), SSTR2(5), SSTR3(11), SSTR4(3), TACR1(7), TACR2(7), TACR3(25), TRHR(19), TSHR(8)	17484509	523	154	497	348	365	46	20	55	37	0	0.000644	1.000	1.000
143	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	80	AIFM1(1), AKT1(3), AKT2(8), AKT3(4), APAF1(6), ATM(12), BAX(3), BCL2(2), BIRC2(5), BIRC3(7), CAPN1(4), CAPN2(6), CASP10(4), CASP3(2), CASP7(4), CASP8(8), CASP9(3), CFLAR(4), CHP(3), CHUK(2), CSF2RB(17), CYCS(1), DFFA(2), DFFB(3), FAS(5), FASLG(14), IKBKB(3), IL1A(4), IL1B(6), IL1R1(11), IL1RAP(4), IL3(3), IL3RA(7), IRAK1(4), IRAK2(14), IRAK3(7), IRAK4(3), MAP3K14(3), MYD88(3), NFKB1(7), NFKB2(4), NFKBIA(2), NTRK1(15), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PRKACA(3), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RELA(4), RIPK1(1), TNF(1), TNFRSF10A(5), TNFRSF10B(2), TNFRSF10C(4), TNFRSF10D(7), TNFRSF1A(3), TNFSF10(7), TP53(39), TRAF2(2)	27775183	434	153	419	208	259	27	22	71	54	1	0.221	1.000	1.000
144	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	29	ATF1(4), BRAF(123), CREB3(1), CREB5(9), DUSP4(1), DUSP6(1), DUSP9(3), EEF2K(5), GRB2(2), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), MKNK1(5), MKNK2(2), MOS(5), NFKB1(7), RAP1A(2), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), SHC1(1), SOS1(8), SOS2(11), TRAF3(5)	9836533	228	153	115	65	84	9	9	117	9	0	0.0251	1.000	1.000
145	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(2), ACVR1B(3), ACVR1C(9), ACVR2A(3), ACVR2B(3), ACVRL1(9), AMHR2(15), BMP2(4), BMP4(3), BMP5(25), BMP6(10), BMP7(2), BMP8A(2), BMP8B(1), BMPR1A(2), BMPR1B(3), BMPR2(5), CHRD(14), COMP(7), CREBBP(20), CUL1(5), DCN(17), E2F4(1), E2F5(1), EP300(14), FST(4), GDF5(13), GDF6(2), GDF7(2), ID2(2), IFNG(2), INHBA(16), INHBB(7), INHBC(11), INHBE(3), LEFTY1(7), LEFTY2(3), LTBP1(43), MAPK1(4), MAPK3(1), MYC(5), NODAL(2), NOG(1), PITX2(4), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(6), RBL1(10), RBL2(4), RHOA(1), ROCK1(5), ROCK2(12), RPS6KB1(2), RPS6KB2(3), SMAD1(5), SMAD2(3), SMAD3(2), SMAD4(2), SMAD5(3), SMAD6(7), SMAD7(2), SMAD9(10), SMURF1(1), SMURF2(9), SP1(5), TFDP1(2), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(8), THBS1(27), THBS2(9), THBS3(10), THBS4(11), TNF(1), ZFYVE16(4), ZFYVE9(8)	33158853	505	152	489	248	333	44	19	58	51	0	0.352	1.000	1.000
146	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	54	AKR1C4(9), AKR1D1(17), ARSD(3), ARSE(5), CARM1(6), CYP11B1(13), CYP11B2(13), CYP19A1(10), HEMK1(4), HSD11B1(11), HSD11B2(2), HSD17B12(2), HSD17B2(9), HSD17B3(5), HSD17B7(1), HSD3B1(10), HSD3B2(10), LCMT1(4), METTL2B(7), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), SRD5A1(2), SRD5A2(6), STS(7), SULT1E1(12), SULT2A1(7), SULT2B1(6), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(8), UGT1A9(10), UGT2A1(18), UGT2A3(24), UGT2B10(36), UGT2B11(19), UGT2B15(25), UGT2B28(24), UGT2B4(31), UGT2B7(17), WBSCR22(1)	16660968	483	151	449	202	333	45	24	33	47	1	1.10e-05	1.000	1.000
147	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), AGK(6), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPAT6(2), AKR1A1(3), AKR1B1(2), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), CEL(11), DAK(3), DGAT1(1), DGAT2(6), DGKA(3), DGKB(22), DGKD(9), DGKE(6), DGKG(16), DGKH(8), DGKI(23), DGKQ(6), DGKZ(7), GK(6), GK2(35), GLA(1), GLB1(8), GPAM(5), LCT(40), LIPA(4), LIPC(8), LIPF(15), LIPG(6), LPL(3), MGLL(6), PNLIP(7), PNLIPRP1(10), PNLIPRP2(2), PNPLA3(2), PPAP2B(6), PPAP2C(8)	19674345	467	150	426	202	320	43	17	54	33	0	0.000171	1.000	1.000
148	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	47	IMPA1(1), IMPA2(2), INPP1(2), INPP4A(5), INPP4B(2), INPP5A(4), INPP5B(6), INPPL1(15), IPMK(2), ISYNA1(1), ITPK1(6), ITPKB(7), MINPP1(1), MIOX(3), OCRL(4), PI4KA(18), PI4KB(4), PIK3C3(3), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIP4K2A(5), PIP4K2B(3), PIP4K2C(3), PIP5K1A(6), PIP5K1B(18), PIP5K1C(8), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PLCD1(3), PLCD3(3), PLCD4(2), PLCE1(48), PLCG1(9), PLCG2(25), PLCZ1(20), PTEN(18), SYNJ1(20), SYNJ2(15)	24640675	482	150	452	210	315	24	24	70	48	1	0.00215	1.000	1.000
149	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(57), COL4A2(30), COL4A3(37), COL4A4(91), COL4A5(53), COL4A6(32), F10(8), F11(12), F12(1), F2(9), F2R(6), F5(30), F8(43), F9(12), FGA(38), FGB(10), FGG(7), KLKB1(23), PROC(8), PROS1(13), SERPINC1(7), SERPING1(12)	14839385	539	150	509	166	412	37	20	44	26	0	0.0537	1.000	1.000
150	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	65	ATM(12), CCNA1(13), CCND1(1), CCND2(5), CCND3(2), CCNE1(4), CCNE2(12), CCNH(2), CDC25A(8), CDK4(5), CDKN1A(4), CDKN1B(1), CDKN2A(34), CDKN2C(1), CREB3(1), CREB3L1(4), CREB3L3(9), CREB3L4(5), E2F1(5), E2F2(4), E2F3(5), E2F4(1), E2F5(1), GBA2(2), MCM2(10), MCM3(10), MCM4(5), MCM5(4), MCM6(4), MDM2(3), MNAT1(2), MYC(5), MYT1(21), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), POLA2(8), POLE(15), POLE2(3), PRIM1(3), RB1(8), RBL1(10), RPA1(3), RPA2(2), RPA3(1), TFDP1(2), TFDP2(4), TNXB(132), TP53(39), WEE1(2)	26441315	452	149	411	163	258	27	16	75	74	2	0.000150	1.000	1.000
151	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	64	APAF1(6), ATM(12), ATR(20), BAI1(14), BAX(3), CASP3(2), CASP8(8), CASP9(3), CCNB2(3), CCNB3(28), CCND1(1), CCND2(5), CCND3(2), CCNE1(4), CCNE2(12), CCNG1(1), CDK4(5), CDK6(2), CDKN1A(4), CDKN2A(34), CHEK1(2), CHEK2(3), CYCS(1), DDB2(3), EI24(3), FAS(5), GADD45B(2), GTSE1(9), IGF1(11), IGFBP3(2), LRDD(4), MDM2(3), MDM4(2), PERP(2), PPM1D(2), PTEN(18), RFWD2(4), RPRM(1), RRM2(2), RRM2B(2), SERPINB5(8), SERPINE1(5), SESN2(6), SESN3(1), SFN(1), STEAP3(6), THBS1(27), TNFRSF10B(2), TP53(39), TP53I3(2), TP73(5), TSC2(11), ZMAT3(1)	21678631	364	148	329	135	190	22	25	54	72	1	0.00428	1.000	1.000
152	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(2), CDC40(4), CLK2(6), CLK3(2), COL2A1(29), CPSF1(6), CPSF2(2), CPSF3(4), CSTF1(5), CSTF2(4), CSTF2T(3), CSTF3(5), DDIT3(2), DDX1(2), DDX20(8), DHX15(4), DHX16(8), DHX38(9), DHX8(11), DHX9(10), DICER1(17), DNAJC8(2), GIPC1(4), LOC440563(21), LSM2(2), LSM7(1), METTL3(2), NCBP1(1), NONO(8), NUDT21(3), NXF1(4), PABPN1(1), PAPOLA(4), PHF5A(1), POLR2A(11), PPM1G(2), PRPF18(4), PRPF3(4), PRPF4(3), PRPF4B(5), PRPF8(12), PSKH1(2), PTBP1(1), PTBP2(7), RBM17(1), RBM5(8), RNGTT(1), RNMT(8), RNPS1(1), SF3A1(7), SF3A2(5), SF3A3(4), SF3B1(14), SF3B2(9), SF3B4(5), SF4(8), SFRS12(2), SFRS14(13), SFRS16(5), SFRS4(2), SFRS5(3), SFRS6(2), SFRS7(2), SFRS8(7), SFRS9(2), SNRPA(2), SNRPA1(1), SNRPB(5), SNRPB2(1), SNRPD1(1), SNRPE(2), SNRPN(5), SNURF(2), SPOP(2), SRPK1(8), SRPK2(2), SRRM1(7), SUPT5H(7), TXNL4A(1), U2AF2(3), XRN2(5)	35579573	411	148	403	179	246	37	22	57	49	0	0.467	1.000	1.000
153	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ABP1(18), ACAT2(1), ACMSD(10), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2), AOC2(7), AOC3(8), AOX1(21), ASMT(6), CAT(5), CYP19A1(10), CYP1A1(10), CYP1A2(10), CYP2A13(11), CYP2A6(11), CYP2A7(8), CYP2B6(16), CYP2C18(26), CYP2C19(35), CYP2C8(30), CYP2C9(35), CYP2D6(1), CYP2E1(13), CYP2F1(11), CYP2J2(5), CYP3A4(19), CYP3A5(10), CYP3A7(18), CYP4B1(20), CYP4F8(15), CYP51A1(1), DDC(12), ECHS1(2), EHHADH(6), GCDH(5), HAAO(3), HADHA(8), KMO(8), KYNU(11), MAOA(3), MAOB(13), SDS(2), TDO2(5), TPH1(5), WARS(4), WARS2(4)	18324675	521	148	492	295	394	34	21	38	34	0	0.0497	1.000	1.000
154	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	63	AKT1(3), AKT2(8), AKT3(4), CDC42(2), CDKN1B(1), CDKN2A(34), CREB3(1), CREB5(9), ERBB4(47), F2RL2(6), GAB1(4), GRB2(2), GSK3B(2), IFI27(2), IGF1(11), IGFBP1(3), INPPL1(15), IRS1(5), IRS2(2), IRS4(12), MET(19), MYC(5), NOLC1(4), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PARD3(15), PARD6A(1), PDK1(2), PIK3CA(8), PIK3CD(7), PPP1R13B(6), PREX1(7), PTEN(18), PTK2(8), PTPN1(4), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(1), SLC2A4(8), SOS1(8), SOS2(11), TSC1(5), TSC2(11), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3)	25832927	421	146	386	183	235	36	20	57	72	1	0.0461	1.000	1.000
155	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(7), BCL2(2), CABIN1(9), CALM1(1), CALM2(1), CAMK2B(4), CAMK4(10), CD3E(2), CD3G(1), CD69(4), CDKN1A(4), CNR1(9), CREBBP(20), CSF2(2), CSNK2A1(1), CSNK2B(1), CTLA4(2), EGR2(4), EGR3(2), EP300(14), FCER1A(12), FCGR3A(8), FOS(2), GATA3(8), GATA4(2), GRLF1(12), GSK3B(2), HRAS(3), ICOS(3), IFNA1(1), IFNB1(6), IFNG(2), IL10(3), IL13(2), IL1B(6), IL2(4), IL2RA(4), IL3(3), IL4(1), IL6(2), IL8(1), ITK(20), KPNA5(1), MAP2K7(4), MAPK14(5), MAPK8(1), MAPK9(5), MEF2A(5), MEF2B(2), MEF2D(4), MYF5(13), NCK2(4), NFAT5(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB2(4), NFKBIB(1), NPPB(5), NUP214(12), OPRD1(2), P2RX7(5), PAK1(4), PIN1(1), PPIA(1), PPP3CB(4), PPP3CC(2), PPP3R1(1), PTPRC(30), RELA(4), RPL13A(2), SFN(1), SLA(2), SP1(5), SP3(1), TGFB1(1), TNF(1), TRAF2(2), TRPV6(29), VAV1(15), VAV2(3), VAV3(9), XPO5(7)	30429423	458	145	441	228	307	30	21	49	51	0	0.181	1.000	1.000
156	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(12), ALG6(2), CCKBR(10), CCR2(16), CCR3(10), CCR5(7), CELSR1(25), CELSR2(23), CELSR3(31), CHRM2(18), CHRM3(19), CXCR3(4), DRD4(1), EDNRA(8), EMR2(4), EMR3(18), F2R(6), FSHR(15), GHRHR(4), GNRHR(2), GPR116(33), GPR132(3), GPR133(13), GPR143(3), GPR17(1), GPR18(5), GPR55(4), GPR56(4), GPR61(8), GPR77(5), GPR84(8), GRM1(16), GRPR(5), HRH4(5), LGR6(17), LPHN2(34), LPHN3(20), LTB4R2(1), NTSR1(6), OR2M4(12), OR8G2(16), P2RY13(4), PTGFR(20), SMO(10), SSTR2(5), TAAR5(3), TSHR(8)	22218291	504	145	484	324	333	43	21	66	40	1	0.150	1.000	1.000
157	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(5), ACADL(4), ACADM(5), ACOX1(7), ACOX2(7), ACOX3(11), ACSL1(4), ACSL3(6), ACSL4(2), ACSL5(20), ACSL6(13), ADIPOQ(3), ANGPTL4(4), APOA1(2), APOA5(6), AQP7(3), CD36(4), CPT1A(10), CPT1B(10), CPT1C(13), CPT2(1), CYP27A1(4), CYP4A11(23), CYP4A22(19), CYP7A1(8), CYP8B1(12), DBI(1), EHHADH(6), FABP1(6), FABP2(6), FABP3(1), FABP4(1), FADS2(3), GK(6), GK2(35), HMGCS2(17), LPL(3), ME1(19), MMP1(11), NR1H3(3), OLR1(5), PCK1(23), PCK2(4), PDPK1(4), PLTP(1), PPARA(6), PPARD(3), PPARG(11), RXRA(4), RXRB(4), RXRG(5), SCD(3), SCP2(2), SLC27A1(3), SLC27A2(12), SLC27A4(4), SLC27A5(6), SLC27A6(27), SORBS1(13), UBC(6), UCP1(4)	21943687	474	144	451	247	339	38	17	40	39	1	0.0637	1.000	1.000
158	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	33	AKT1(3), AKT2(8), AKT3(4), BCR(10), BTK(15), CD19(7), CDKN2A(34), DAPP1(5), FLOT1(2), GAB1(4), ITPR1(29), ITPR2(17), ITPR3(6), LYN(6), NR0B2(6), PDK1(2), PIK3CA(8), PITX2(4), PLCG2(25), PPP1R13B(6), PREX1(7), PTEN(18), PTPRC(30), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KB1(2), SAG(9), SYK(14), TEC(10), VAV1(15)	18383228	321	141	285	158	191	19	19	33	59	0	0.0570	1.000	1.000
159	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	48	ACCN1(11), ADCY4(4), ADCY6(6), ADCY8(45), CACNA1A(32), CACNA1B(26), GNAS(19), GNAT3(3), GNB3(7), GRM4(19), ITPR3(6), KCNB1(31), PDE1A(35), PLCB2(9), PRKACA(3), PRKACB(4), PRKACG(8), PRKX(3), SCNN1A(7), SCNN1B(13), SCNN1G(26), TAS1R1(10), TAS1R2(23), TAS1R3(2), TAS2R1(8), TAS2R10(7), TAS2R13(2), TAS2R14(2), TAS2R16(8), TAS2R3(1), TAS2R38(14), TAS2R39(10), TAS2R4(3), TAS2R40(4), TAS2R41(12), TAS2R42(2), TAS2R43(1), TAS2R46(2), TAS2R5(3), TAS2R50(1), TAS2R60(16), TAS2R7(3), TAS2R8(4), TAS2R9(6), TRPM5(13)	18901366	474	140	444	389	325	35	19	54	41	0	0.927	1.000	1.000
160	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	59	ALG2(4), BAX(3), BTK(15), CAD(15), CASP10(4), CASP3(2), CASP8(8), CASP8AP2(7), CDK2AP1(2), CSNK1A1(2), DAXX(9), DEDD(1), DEDD2(3), DFFA(2), DIABLO(1), EGFR(22), EPHB2(29), FAF1(7), FAIM2(5), HSPB1(2), IL1A(4), IL8(1), MAP2K4(4), MAP2K7(4), MAP3K1(2), MAP3K5(16), MAPK1(4), MAPK10(8), MAPK8(1), MAPK8IP1(4), MAPK8IP2(7), MAPK8IP3(8), MAPK9(5), MET(19), NFAT5(7), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), NR0B2(6), PTPN13(12), RALBP1(2), RIPK1(1), ROCK1(5), SMPD1(3), TNFRSF6B(2), TP53(39), TPX2(9), TRAF2(2), TUFM(5)	24257139	344	140	331	172	199	23	21	49	52	0	0.460	1.000	1.000
161	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACSS2(4), ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), AKR1A1(3), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH7A1(9), ALDH9A1(2), ALDOA(2), ALDOB(12), ALDOC(3), BPGM(2), DLAT(2), DLD(2), ENO1(4), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(5), G6PC2(4), GALM(2), GAPDH(1), GAPDHS(1), GCK(17), GPI(3), HK1(3), HK2(12), HK3(13), LDHA(5), LDHAL6A(4), LDHAL6B(7), LDHB(2), LDHC(5), PDHA1(3), PDHA2(17), PDHB(1), PFKL(4), PFKM(1), PGAM2(3), PGK1(4), PGK2(27), PGM1(4), PGM3(1), PKLR(11), PKM2(5)	19458510	364	138	329	165	254	31	18	38	23	0	0.000275	1.000	1.000
162	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(18), ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), ALDH1A3(2), ALDH3A1(5), ALDH3B1(2), ALDH3B2(7), AOC2(7), AOC3(8), AOX1(21), CARM1(6), COMT(3), DBH(13), DCT(3), DDC(12), ECH1(1), ESCO1(1), ESCO2(2), FAH(4), GOT1(6), GOT2(5), HEMK1(4), HGD(12), HPD(5), LCMT1(4), MAOA(3), MAOB(13), METTL2B(7), METTL6(2), MYST3(15), MYST4(14), NAT6(2), PNMT(4), PNPLA3(2), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), SH3GLB1(2), TAT(17), TH(9), TPO(40), TYR(8), TYRP1(8), WBSCR22(1)	19850042	433	136	407	215	313	37	22	39	22	0	0.0387	1.000	1.000
163	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	44	ACTR2(3), ACTR3(2), AKT1(3), AKT2(8), AKT3(4), ANGPTL2(2), ARHGAP1(2), ARHGAP4(2), ARHGEF11(17), BTK(15), CDC42(2), CFL1(1), GDI1(1), GDI2(2), INPPL1(15), ITPR1(29), ITPR2(17), ITPR3(6), LIMK1(4), MYLK(39), MYLK2(10), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PDK1(2), PIK3CA(8), PIK3CD(7), PIK3CG(24), PIK3R1(3), PITX2(4), PPP1R13B(6), PTEN(18), RACGAP1(3), RHO(2), ROCK1(5), ROCK2(12), SAG(9), WASF1(4), WASL(5)	23350780	372	135	349	163	234	31	15	52	39	1	0.00703	1.000	1.000
164	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(7), AGT(5), AGTR1(10), AGTR2(9), CMA1(5), COL4A1(57), COL4A2(30), COL4A3(37), COL4A4(91), COL4A5(53), COL4A6(32), REN(9)	8428727	345	134	324	102	282	17	8	23	15	0	0.490	1.000	1.000
165	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(5), ACAA2(1), ACADL(4), ACADM(5), ACADS(4), ACADSB(6), ACADVL(1), ACAT2(1), ACOX1(7), ACOX3(11), ACSL1(4), ACSL3(6), ACSL4(2), ACSL5(20), ACSL6(13), ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), CPT1A(10), CPT1B(10), CPT1C(13), CPT2(1), CYP4A11(23), CYP4A22(19), DCI(2), ECHS1(2), EHHADH(6), GCDH(5), HADHA(8), HADHB(4), HSD17B10(2), HSD17B4(6), PECI(2)	16451812	346	134	319	150	247	29	18	27	24	1	0.00271	1.000	1.000
166	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(1), APH1A(2), CREBBP(20), CTBP2(1), DLL1(2), DLL3(6), DLL4(6), DTX1(8), DTX2(3), DTX3(4), DTX3L(6), DTX4(4), DVL2(3), DVL3(7), EP300(14), HDAC1(1), HDAC2(1), HES1(2), JAG1(8), JAG2(7), LFNG(3), MAML1(4), MAML2(6), MAML3(7), MFNG(7), NCOR2(24), NCSTN(4), NOTCH1(6), NOTCH2(41), NOTCH3(23), NOTCH4(54), NUMB(4), NUMBL(4), PSEN1(1), PSEN2(2), PTCRA(3), RBPJ(4), RBPJL(3), SNW1(2)	22959459	308	134	301	161	180	29	11	60	28	0	0.775	1.000	1.000
167	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(12), ACTB(7), ACTG1(5), ARHGEF2(17), ARPC5(1), CD14(5), CDC42(2), CDH1(5), CLDN1(5), CTNNB1(11), CTTN(2), EZR(1), FYN(6), HCLS1(9), ITGB1(4), KRT18(3), LY96(4), NCK1(1), NCK2(4), NCL(6), OCLN(4), PRKCA(10), RHOA(1), ROCK1(5), ROCK2(12), TLR4(31), TLR5(18), TUBA1A(2), TUBA1B(4), TUBA1C(2), TUBA3C(21), TUBA3D(11), TUBA3E(3), TUBA4A(6), TUBA8(3), TUBAL3(11), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(5), TUBB4(3), TUBB4Q(9), TUBB6(10), TUBB8(13), WAS(7), WASL(5), YWHAQ(3)	17522016	316	134	303	129	206	32	11	35	32	0	0.000576	1.000	1.000
168	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(12), ACTB(7), ACTG1(5), ARHGEF2(17), ARPC5(1), CD14(5), CDC42(2), CDH1(5), CLDN1(5), CTNNB1(11), CTTN(2), EZR(1), FYN(6), HCLS1(9), ITGB1(4), KRT18(3), LY96(4), NCK1(1), NCK2(4), NCL(6), OCLN(4), PRKCA(10), RHOA(1), ROCK1(5), ROCK2(12), TLR4(31), TLR5(18), TUBA1A(2), TUBA1B(4), TUBA1C(2), TUBA3C(21), TUBA3D(11), TUBA3E(3), TUBA4A(6), TUBA8(3), TUBAL3(11), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(5), TUBB4(3), TUBB4Q(9), TUBB6(10), TUBB8(13), WAS(7), WASL(5), YWHAQ(3)	17522016	316	134	303	129	206	32	11	35	32	0	0.000576	1.000	1.000
169	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(3), ACP2(2), ACP5(3), ACPP(8), ALPI(8), ALPL(9), ALPP(9), ALPPL2(11), CYP19A1(10), CYP1A1(10), CYP1A2(10), CYP2A13(11), CYP2A6(11), CYP2A7(8), CYP2B6(16), CYP2C18(26), CYP2C19(35), CYP2C8(30), CYP2C9(35), CYP2D6(1), CYP2E1(13), CYP2F1(11), CYP2J2(5), CYP3A4(19), CYP3A5(10), CYP3A7(18), CYP4B1(20), CYP4F8(15), CYP51A1(1), PON1(14)	9717151	382	133	353	210	303	21	12	18	28	0	0.00151	1.000	1.000
170	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	86	AICDA(9), CAD(15), CANT1(9), CDA(2), CTPS(2), CTPS2(3), DCTD(2), DHODH(3), DPYD(56), DPYS(22), ENTPD1(10), ENTPD3(6), ENTPD4(4), ENTPD5(1), ENTPD6(4), ENTPD8(2), NME6(2), NME7(4), NT5C1A(3), NT5C1B(22), NT5C2(3), NT5C3(2), NT5E(4), NT5M(2), PNPT1(1), POLA1(2), POLA2(8), POLD1(6), POLD2(2), POLD3(4), POLE(15), POLE2(3), POLR1A(11), POLR1B(8), POLR1C(1), POLR2A(11), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(4), POLR3B(17), POLR3G(1), POLR3GL(1), POLR3H(1), POLR3K(1), PRIM1(3), PRIM2(15), RRM1(3), RRM2(2), RRM2B(2), TK2(1), TXNRD1(5), TXNRD2(3), TYMS(1), UCK1(2), UMPS(1), UPB1(6), UPP2(5), UPRT(1)	27093083	360	133	341	181	231	33	17	51	28	0	0.230	1.000	1.000
171	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH6(11), ADH7(13), ADHFE1(5), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AKR1A1(3), AKR1B1(2), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2), CEL(11), DGAT1(1), DGKA(3), DGKB(22), DGKD(9), DGKE(6), DGKG(16), DGKH(8), DGKQ(6), DGKZ(7), GK(6), GLA(1), GLB1(8), LCT(40), LIPC(8), LIPF(15), LIPG(6), LPL(3), PNLIP(7), PNLIPRP1(10), PNLIPRP2(2), PPAP2B(6), PPAP2C(8)	16139244	378	132	346	176	268	36	13	39	22	0	0.00369	1.000	1.000
172	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(17), ACSL1(4), ACSL3(6), ACSL4(2), ACSL5(20), ACSL6(13), ADIPOQ(3), ADIPOR1(5), ADIPOR2(1), AGRP(1), AKT1(3), AKT2(8), AKT3(4), CAMKK1(3), CAMKK2(7), CD36(4), CHUK(2), CPT1A(10), CPT1B(10), CPT1C(13), CPT2(1), G6PC(5), G6PC2(4), IKBKB(3), IRS1(5), IRS2(2), IRS4(12), JAK1(6), JAK2(9), JAK3(6), LEP(2), LEPR(22), MAPK10(8), MAPK8(1), MAPK9(5), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NPY(4), PCK1(23), PCK2(4), POMC(3), PPARA(6), PPARGC1A(20), PRKAA1(1), PRKAA2(24), PRKAB1(2), PRKAB2(2), PRKAG1(2), PRKAG2(7), PRKAG3(10), PRKCQ(16), PTPN11(9), RELA(4), RXRA(4), RXRB(4), RXRG(5), SLC2A1(4), SLC2A4(8), SOCS3(2), STAT3(10), STK11(3), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF2(2), TYK2(7)	27751707	434	132	419	244	270	44	22	47	51	0	0.569	1.000	1.000
173	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(4), AGT(5), AKT1(3), CALM1(1), CALM2(1), CALR(1), CAMK1(4), CAMK1G(9), CAMK4(10), CREBBP(20), CSNK1A1(2), EDN1(8), ELSPBP1(4), F2(9), FGF2(2), FKBP1A(2), GATA4(2), GSK3B(2), HAND1(2), HAND2(5), HRAS(3), IGF1(11), LIF(2), MAP2K1(10), MAPK1(4), MAPK14(5), MAPK3(1), MAPK8(1), MEF2C(2), MYH2(77), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NKX2-5(1), NPPA(3), PIK3CA(8), PIK3R1(3), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RAF1(8), RPS6KB1(2), SYT1(19)	16985356	335	131	313	183	235	26	15	33	25	1	0.494	1.000	1.000
174	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(4), AKT1(3), BDKRB2(9), CALM1(1), CALM2(1), CAV1(1), CHRM1(5), CHRNA1(5), FLT1(33), FLT4(23), KDR(42), NOS3(16), PDE2A(13), PDE3A(24), PDE3B(6), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKG1(12), PRKG2(13), RYR2(84), SLC7A1(3), SYT1(19), TNNI1(1)	13607606	340	130	321	197	240	26	10	32	31	1	0.338	1.000	1.000
175	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	58	APC(19), AXIN1(10), CCND1(1), CCND2(5), CCND3(2), CSNK1E(4), CTNNB1(11), DVL2(3), DVL3(7), FBXW2(2), FZD1(4), FZD10(2), FZD2(5), FZD5(2), FZD6(2), FZD7(4), FZD8(4), FZD9(1), GSK3B(2), JUN(1), LDLR(14), MAPK10(8), MAPK9(5), MYC(5), PAFAH1B1(4), PLAU(3), PPP2R5C(4), PPP2R5E(4), PRKCA(10), PRKCD(4), PRKCE(6), PRKCG(13), PRKCH(10), PRKCI(8), PRKCQ(16), PRKCZ(5), PRKD1(3), RAC1(17), RHOA(1), SFRP4(6), TCF7(1), WNT1(2), WNT10A(7), WNT10B(5), WNT11(4), WNT16(1), WNT2(7), WNT2B(4), WNT3(5), WNT4(2), WNT5A(5), WNT5B(5), WNT6(2), WNT7A(13), WNT7B(6)	19914701	306	130	291	162	196	29	8	36	37	0	0.204	1.000	1.000
176	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	41	ALAD(5), ALAS1(1), ALAS2(5), BLVRA(2), BLVRB(1), COX10(5), COX15(4), CP(11), CPOX(4), EPRS(9), FECH(3), FTH1(3), FTMT(7), GUSB(3), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), MMAB(2), PPOX(3), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(8), UGT1A9(10), UGT2A1(18), UGT2A3(24), UGT2B10(36), UGT2B11(19), UGT2B15(25), UGT2B28(24), UGT2B4(31), UGT2B7(17), UROS(1)	14078252	349	129	325	136	239	30	19	22	38	1	0.000315	1.000	1.000
177	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(4), BMP4(3), BMP5(25), BMP6(10), BMP7(2), BMP8A(2), BMP8B(1), BTRC(4), CSNK1A1(2), CSNK1A1L(5), CSNK1D(1), CSNK1E(4), CSNK1G1(4), CSNK1G2(2), CSNK1G3(3), DHH(1), FBXW11(5), GLI1(14), GLI2(36), GLI3(15), GSK3B(2), HHIP(21), IHH(2), LRP2(87), PRKACA(3), PRKACB(4), PRKACG(8), PRKX(3), PTCH1(8), PTCH2(16), RAB23(1), SHH(4), SMO(10), STK36(13), SUFU(2), WNT1(2), WNT10A(7), WNT10B(5), WNT11(4), WNT16(1), WNT2(7), WNT2B(4), WNT3(5), WNT3A(6), WNT4(2), WNT5A(5), WNT5B(5), WNT6(2), WNT7A(13), WNT7B(6), WNT8A(7), WNT8B(7), WNT9A(3), WNT9B(3), ZIC2(2)	20127806	423	129	402	208	292	37	19	41	34	0	0.0342	1.000	1.000
178	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	49	AKT1(3), AKT2(8), AKT3(4), BRD4(19), CAP1(1), CBL(8), CDC42(2), CDKN2A(34), F2RL2(6), FLOT1(2), GRB2(2), GSK3B(2), IGFBP1(3), INPPL1(15), IRS1(5), IRS2(2), IRS4(12), LNPEP(10), MAPK1(4), MAPK3(1), PARD3(15), PARD6A(1), PDK1(2), PIK3CA(8), PIK3CD(7), PIK3R1(3), PPYR1(12), PTEN(18), PTPN1(4), RAF1(8), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KB1(2), SERPINB6(4), SFN(1), SHC1(1), SLC2A4(8), SORBS1(13), SOS1(8), SOS2(11), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3)	19950917	290	129	267	120	143	27	16	45	58	1	0.111	1.000	1.000
179	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	38	AKT1(3), ATF2(5), CDC42(2), DLD(2), DUSP10(6), DUSP4(1), DUSP8(3), GAB1(4), GCK(17), IL1R1(11), JUN(1), MAP2K4(4), MAP2K5(3), MAP2K7(4), MAP3K1(2), MAP3K10(8), MAP3K11(6), MAP3K12(3), MAP3K13(10), MAP3K2(6), MAP3K3(6), MAP3K4(17), MAP3K5(16), MAP3K7(1), MAP3K9(22), MAPK10(8), MAPK7(4), MAPK8(1), MAPK9(5), MYEF2(4), NFATC3(9), NR2C2(2), PAPPA(50), SHC1(1), TP53(39), TRAF6(4), ZAK(6)	16804869	296	129	281	118	195	22	11	32	35	1	0.0682	1.000	1.000
180	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(3), AKT2(8), AKT3(4), BCL2(2), BCR(10), BLNK(12), BTK(15), CD19(7), CD22(22), CD81(2), CR2(32), CSK(1), DAG1(5), FLOT1(2), GRB2(2), GSK3B(2), INPP5D(31), ITPR1(29), ITPR2(17), ITPR3(6), LYN(6), MAP4K1(9), MAPK1(4), MAPK3(1), NFATC1(15), NFATC2(9), NR0B2(6), PDK1(2), PIK3CA(8), PIK3CD(7), PIK3R1(3), PLCG2(25), PPP1R13B(6), PPP3CA(5), PPP3CB(4), PPP3CC(2), PTPRC(30), RAF1(8), SHC1(1), SOS1(8), SOS2(11), SYK(14), VAV1(15)	24674181	411	128	396	195	268	30	24	45	43	1	0.0198	1.000	1.000
181	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH6(11), ADH7(13), ADHFE1(5), AKR1A1(3), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH9A1(2), ALDOA(2), ALDOB(12), ALDOC(3), BPGM(2), DLAT(2), DLD(2), ENO1(4), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(5), GAPDH(1), GCK(17), GPI(3), HK1(3), HK2(12), HK3(13), LDHA(5), LDHB(2), LDHC(5), PDHA1(3), PDHA2(17), PDHB(1), PFKM(1), PGK1(4), PGM1(4), PGM3(1), PKLR(11), PKM2(5)	16333330	310	127	282	133	218	30	14	29	19	0	0.000102	1.000	1.000
182	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH6(11), ADH7(13), ADHFE1(5), AKR1A1(3), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH9A1(2), ALDOA(2), ALDOB(12), ALDOC(3), BPGM(2), DLAT(2), DLD(2), ENO1(4), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(5), GAPDH(1), GCK(17), GPI(3), HK1(3), HK2(12), HK3(13), LDHA(5), LDHB(2), LDHC(5), PDHA1(3), PDHA2(17), PDHB(1), PFKM(1), PGK1(4), PGM1(4), PGM3(1), PKLR(11), PKM2(5)	16333330	310	127	282	133	218	30	14	29	19	0	0.000102	1.000	1.000
183	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(5), CALR(1), CANX(1), CD4(6), CD74(6), CD8A(2), CD8B(7), CIITA(15), CTSL1(1), CTSS(6), HLA-A(6), HLA-B(5), HLA-C(1), HLA-DMA(4), HLA-DMB(7), HLA-DOA(4), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(7), HLA-DQB1(5), HLA-DRA(11), HLA-DRB1(3), HLA-DRB5(1), HLA-E(1), HLA-F(6), HLA-G(3), HSP90AA1(2), HSP90AB1(5), HSPA5(5), IFI30(2), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(9), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(5), IFNA8(3), KIR2DL1(21), KIR2DL3(6), KIR2DL4(3), KIR2DS4(15), KIR3DL1(17), KIR3DL2(2), KIR3DL3(6), KLRC1(4), KLRC2(1), KLRC3(11), KLRC4(5), KLRD1(5), LGMN(5), LTA(2), NFYA(1), NFYB(3), NFYC(1), PDIA3(3), PSME2(4), RFX5(5), RFXANK(1), RFXAP(1), TAP1(1), TAP2(13), TAPBP(2)	15365062	319	127	308	179	212	29	15	34	29	0	0.293	1.000	1.000
184	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	65	ADAM10(7), ADAM17(1), ATP6AP1(2), ATP6V0A1(9), ATP6V0A2(4), ATP6V0A4(19), ATP6V0D2(8), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), CASP3(2), CDC42(2), CHUK(2), CSK(1), EGFR(22), F11R(5), GIT1(4), HBEGF(1), IGSF5(10), IKBKB(3), IL8(1), JAM2(10), JAM3(2), JUN(1), LYN(6), MAP2K4(4), MAP3K14(3), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK8(1), MAPK9(5), MET(19), NFKB1(7), NFKB2(4), NFKBIA(2), NOD1(6), PAK1(4), PLCG1(9), PLCG2(25), PTPN11(9), PTPRZ1(22), RAC1(17), RELA(4), SRC(1), TCIRG1(3), TJP1(11)	23541661	334	124	320	195	214	28	16	48	28	0	0.779	1.000	1.000
185	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(57), COL4A2(30), COL4A3(37), COL4A4(91), COL4A5(53), COL4A6(32), P4HB(2), SLC23A1(4), SLC23A2(4), SLC2A1(4), SLC2A3(7)	8332233	321	124	302	86	265	14	9	20	13	0	0.0976	1.000	1.000
186	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	25	AKR1B1(2), GUSB(3), UGDH(1), UGP2(1), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(8), UGT1A9(10), UGT2A1(18), UGT2A3(24), UGT2B10(36), UGT2B11(19), UGT2B15(25), UGT2B28(24), UGT2B4(31), UGT2B7(17), XYLB(4)	9088625	286	123	263	117	202	23	15	17	28	1	0.00314	1.000	1.000
187	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP1(2), INPP4A(5), INPP4B(2), INPP5A(4), INPPL1(15), ITPKB(7), MIOX(3), OCRL(4), PIK3C2A(6), PIK3C2B(13), PIK3C2G(43), PIK3CA(8), PIK3CB(21), PIK3CG(24), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PLCD1(3), PLCG1(9), PLCG2(25)	14902285	325	123	297	140	226	14	14	39	31	1	0.00633	1.000	1.000
188	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(8), CD28(1), CD3D(5), CSK(1), CTLA4(2), DAG1(5), EPHB2(29), FBXW7(11), GRAP2(4), GRB2(2), ITK(20), ITPKB(7), LAT(1), LCK(12), LCP2(9), MAPK1(4), NCK1(1), NFAT5(7), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PLCG1(9), PTPRC(30), RAF1(8), RASGRP1(7), RASGRP2(6), RASGRP3(13), RASGRP4(10), SOS1(8), SOS2(11), VAV1(15), ZAP70(8)	18516307	351	123	336	165	220	29	18	47	37	0	0.113	1.000	1.000
189	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(5), ACTG2(4), ACTR2(3), ACTR3(2), AKT1(3), ANGPTL2(2), CDC42(2), CFL1(1), FLNA(15), FLNC(56), FSCN1(4), FSCN2(2), FSCN3(10), GDI1(1), GDI2(2), LIMK1(4), MYH2(77), MYLK(39), MYLK2(10), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), RHO(2), ROCK1(5), ROCK2(12), VASP(3), WASF1(4), WASL(5)	15936697	349	122	324	185	241	44	9	33	22	0	0.0356	1.000	1.000
190	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(18), ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH6(11), ADH7(13), ADHFE1(5), ALDH1A3(2), ALDH3A1(5), ALDH3B1(2), ALDH3B2(7), AOC2(7), AOC3(8), AOX1(21), COMT(3), DBH(13), DCT(3), DDC(12), FAH(4), GOT1(6), GOT2(5), HGD(12), HPD(5), MAOA(3), MAOB(13), PNMT(4), TAT(17), TH(9), TPO(40), TYR(8)	10557864	335	122	311	161	255	26	17	21	16	0	0.00158	1.000	1.000
191	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	66	APAF1(6), BAX(3), BCL2(2), BCL2L11(5), BIRC2(5), BIRC3(7), BIRC5(1), BNIP3L(2), CASP1(4), CASP10(4), CASP2(1), CASP3(2), CASP4(1), CASP7(4), CASP8(8), CASP9(3), CHUK(2), CYCS(1), DFFA(2), DFFB(3), FAS(5), FASLG(14), GZMB(3), HELLS(5), IKBKB(3), IRF1(1), IRF2(5), IRF3(3), IRF4(3), IRF5(4), IRF6(13), IRF7(7), JUN(1), LTA(2), MAP2K4(4), MAP3K1(2), MAPK10(8), MDM2(3), MYC(5), NFKB1(7), NFKBIA(2), NFKBIB(1), PLEKHG5(10), PRF1(11), RELA(4), RIPK1(1), TNF(1), TNFRSF10B(2), TNFRSF1A(3), TNFRSF1B(3), TNFRSF21(10), TNFRSF25(5), TNFSF10(7), TP53(39), TP73(5), TRAF1(6), TRAF2(2), TRAF3(5)	19106983	281	121	273	133	178	26	17	28	32	0	0.161	1.000	1.000
192	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(9), ALOX12(5), ALOX12B(13), ALOX15(8), ALOX15B(8), ALOX5(8), CBR3(1), CYP2B6(16), CYP2C18(26), CYP2C19(35), CYP2C8(30), CYP2C9(35), CYP2E1(13), CYP2J2(5), CYP2U1(1), CYP4A11(23), CYP4A22(19), CYP4F2(12), CYP4F3(19), EPHX2(4), GGT1(6), GPX1(7), GPX3(3), GPX5(12), GPX6(15), LTA4H(4), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PTGDS(2), PTGES2(1), PTGIS(12), PTGS1(17), PTGS2(10), TBXAS1(11)	12915262	447	121	419	284	355	27	6	27	31	1	0.168	1.000	1.000
193	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(3), AKT2(8), AKT3(4), BCR(10), BLNK(12), BTK(15), CD19(7), CSK(1), DAG1(5), EPHB2(29), GRB2(2), ITPKB(7), LYN(6), MAP2K1(10), MAP2K2(3), MAPK1(4), NFAT5(7), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PI3(6), PIK3CA(8), PIK3CD(7), PIK3R1(3), PLCG2(25), PPP1R13B(6), RAF1(8), SERPINA4(14), SHC1(1), SOS1(8), SOS2(11), SYK(14), VAV1(15)	17654407	280	121	268	148	173	21	15	41	29	1	0.429	1.000	1.000
194	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	23	ADRB1(5), AKT1(3), APC(19), CAMP(1), DAG1(5), DLG4(4), EPHB2(29), GNAI1(1), GNAQ(4), ITPR1(29), ITPR2(17), ITPR3(6), KCNJ3(18), KCNJ5(12), KCNJ9(4), MAPK1(4), PITX2(4), PTX3(1), RAC1(17), RHO(2), RYR1(87)	15208720	272	121	254	170	191	25	12	21	23	0	0.382	1.000	1.000
195	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	37	CALM1(1), CALM2(1), CAMK1(4), CAMK1G(9), ELK1(2), FPR1(18), GNA15(5), HRAS(3), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K6(3), MAP3K1(2), MAPK1(4), MAPK14(5), MAPK3(1), NCF1(1), NCF2(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB1(7), NFKBIA(2), PAK1(4), PIK3C2G(43), PLCB1(48), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAC1(17), RAF1(8), RELA(4), SYT1(19)	12717102	295	120	263	120	213	15	9	30	28	0	0.00799	1.000	1.000
196	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(8), F11(12), F12(1), F13B(23), F2(9), F5(30), F7(7), F8(43), F9(12), FGA(38), FGB(10), FGG(7), LPA(47), PLAT(3), PLAU(3), PLG(30), SERPINB2(16), SERPINE1(5), SERPINF2(6), VWF(49)	11731017	359	119	340	146	254	27	22	24	31	1	0.0135	1.000	1.000
197	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(5), AANAT(1), ABP1(18), ACAT2(1), ACMSD(10), AFMID(2), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), AOC2(7), AOC3(8), AOX1(21), ASMT(6), CARM1(6), CAT(5), CYP1A1(10), CYP1A2(10), CYP1B1(2), DDC(12), ECHS1(2), EHHADH(6), GCDH(5), HAAO(3), HADHA(8), HEMK1(4), HSD17B10(2), HSD17B4(6), INMT(8), KMO(8), KYNU(11), LCMT1(4), LNX1(17), MAOA(3), MAOB(13), METTL2B(7), METTL6(2), NFX1(6), OGDH(11), OGDHL(36), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), TDO2(5), TPH1(5), TPH2(12), WARS(4), WARS2(4), WBSCR22(1)	20221639	373	119	359	192	259	30	19	42	23	0	0.0975	1.000	1.000
198	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(48), B3GALT4(2), CDR1(12), DGKI(23), IL6ST(10), MRPL19(1), PIGK(6), RPL10(4), RPL11(2), RPL13A(2), RPL14(1), RPL15(2), RPL18(3), RPL18A(1), RPL19(1), RPL21(1), RPL22(2), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL38(1), RPL39(1), RPL3L(3), RPL4(5), RPL5(6), RPL6(1), RPL7(2), RPL7A(1), RPLP0(1), RPS10(1), RPS11(1), RPS13(1), RPS15(1), RPS16(1), RPS18(1), RPS2(2), RPS20(2), RPS23(1), RPS24(1), RPS27(1), RPS29(1), RPS3A(1), RPS5(1), RPS6(1), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KA6(15), RPS6KB1(2), RPS6KB2(3), RPS7(4), RPS8(1), RPSA(1), SLC36A2(7), TBC1D10C(5), TSPAN9(3), UBB(1), UBC(6)	17346050	233	119	223	135	144	22	13	32	22	0	0.712	1.000	1.000
199	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(18), AGMAT(3), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH4A1(6), ALDH9A1(2), AOC2(7), AOC3(8), ARG1(1), ARG2(1), ASL(6), CKM(2), CKMT1A(1), CKMT2(5), CPS1(21), DAO(10), GAMT(4), GATM(5), GLUD1(2), GOT1(6), GOT2(5), MAOA(3), MAOB(13), NOS1(58), NOS3(16), OAT(3), ODC1(3), OTC(4), P4HA1(9), P4HA2(4), P4HA3(12), P4HB(2), PYCR1(1), RARS(7), SMS(5)	14710616	289	117	277	166	190	33	15	24	27	0	0.304	1.000	1.000
200	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	13	C1QA(4), C1QB(3), C1R(13), C1S(15), C2(14), C3(46), C5(14), C6(56), C7(43), C8A(37), C8B(43), C9(19), MASP1(8)	6886281	315	117	279	130	242	15	9	28	20	1	0.00182	1.000	1.000
201	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(12), BMPR1B(3), CCND2(5), CDK4(5), CDKN1B(1), DAZL(4), DMC1(10), EGR1(4), ESR2(6), FSHR(15), GJA4(4), INHA(4), LHCGR(24), MLH1(6), MSH5(14), NCOR1(19), NR5A1(7), NRIP1(8), PGR(15), PRLR(29), PTGER2(6), SMPD1(3), VDR(2), ZP2(13)	11659638	219	117	198	114	151	15	4	26	23	0	0.616	1.000	1.000
202	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), CALM2(1), DLG4(4), GRIN1(7), GRIN2A(86), GRIN2B(53), GRIN2C(8), GRIN2D(6), NOS1(58), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), SYT1(19)	8505068	286	116	268	181	213	28	5	19	21	0	0.332	1.000	1.000
203	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	14	C1QA(4), C1QB(3), C1R(13), C1S(15), C2(14), C3(46), C5(14), C6(56), C7(43), C8A(37), C9(19), MASP1(8), MASP2(9), MBL2(12)	7058231	293	115	261	120	226	13	5	26	22	1	0.00201	1.000	1.000
204	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(9), ABP1(18), ACADL(4), ACADM(5), ACADSB(6), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2), AOC2(7), AOC3(8), CNDP1(8), DPYD(56), DPYS(22), ECHS1(2), EHHADH(6), GAD1(13), GAD2(7), HADHA(8), MLYCD(2), SDS(2), SMS(5), UPB1(6)	9726245	232	114	218	113	155	21	12	29	15	0	0.112	1.000	1.000
205	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(2), ALDOB(12), ALDOC(3), DLAT(2), DLD(2), ENO1(4), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(5), GAPDH(1), GAPDHS(1), GCK(17), GOT1(6), GOT2(5), GPI(3), HK1(3), HK2(12), HK3(13), LDHA(5), LDHAL6B(7), LDHB(2), LDHC(5), MDH1(1), MDH2(4), PC(12), PCK1(23), PDHA1(3), PDHA2(17), PDHB(1), PDHX(2), PFKL(4), PFKM(1), PGAM2(3), PGK1(4), PGK2(27), PKLR(11), PKM2(5), TNFAIP1(1)	14224075	241	113	226	117	175	18	12	20	16	0	0.00273	1.000	1.000
206	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(6), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPAT6(2), CDS1(9), CDS2(4), CHAT(14), CHKA(2), CHKB(3), CHPT1(1), CRLS1(1), DGKA(3), DGKB(22), DGKD(9), DGKE(6), DGKG(16), DGKH(8), DGKI(23), DGKQ(6), DGKZ(7), ESCO1(1), ESCO2(2), ETNK1(4), GNPAT(2), GPAM(5), GPD1(8), GPD1L(2), GPD2(2), LYPLA1(1), LYPLA2(1), MYST3(15), MYST4(14), NAT6(2), PCYT1A(3), PCYT1B(7), PEMT(2), PISD(2), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PLD1(11), PLD2(5), PNPLA3(2), PPAP2B(6), PPAP2C(8), PTDSS2(1), SH3GLB1(2)	21827869	325	113	310	183	211	29	9	42	34	0	0.630	1.000	1.000
207	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(46), C5(14), C6(56), C7(43), ICAM1(2), IL1A(4), IL6(2), IL8(1), ITGA4(36), ITGAL(24), ITGB1(4), ITGB2(13), SELP(30), SELPLG(8), TNF(1), VCAM1(16)	8229017	300	113	272	125	220	9	14	26	30	1	0.00185	1.000	1.000
208	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	35	ACTA1(4), CRK(2), CRKL(2), DOCK1(15), ELK1(2), FOS(2), GAB1(4), GRB2(2), HGF(23), HRAS(3), ITGA1(18), ITGB1(4), JUN(1), MAP2K1(10), MAP2K2(3), MAP4K1(9), MAPK1(4), MAPK3(1), MAPK8(1), MET(19), PAK1(4), PIK3CA(8), PIK3R1(3), PTEN(18), PTK2(8), PTK2B(10), PTPN11(9), PXN(3), RAF1(8), RAP1A(2), RAP1B(1), RASA1(4), SOS1(8), SRC(1), STAT3(10)	14596238	226	113	212	103	130	16	10	37	32	1	0.582	1.000	1.000
209	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	33	A1BG(2), AKT1(3), AKT2(8), AKT3(4), BTK(15), CDKN2A(34), DAPP1(5), GRB2(2), GSK3B(2), IARS(8), IGFBP1(3), INPP5D(31), PDK1(2), PIK3CA(8), PPP1R13B(6), PTEN(18), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(1), SOS1(8), SOS2(11), TEC(10), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3)	12047509	205	113	177	60	107	11	14	26	47	0	0.00144	1.000	1.000
210	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(2), C1GALT1(6), C1GALT1C1(2), GALNT1(4), GALNT10(6), GALNT11(2), GALNT12(8), GALNT13(25), GALNT14(27), GALNT2(6), GALNT3(3), GALNT4(4), GALNT5(9), GALNT6(15), GALNT7(5), GALNT8(23), GALNT9(5), GALNTL1(4), GALNTL2(19), GALNTL4(6), GALNTL5(14), GCNT1(6), GCNT3(5), GCNT4(4), OGT(10), ST3GAL1(6), ST3GAL2(1), ST6GALNAC1(5), WBSCR17(37)	10798624	269	112	253	129	202	13	6	24	24	0	0.121	1.000	1.000
211	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(15), CANT1(9), CDA(2), CTPS(2), CTPS2(3), DCTD(2), DHODH(3), DPYD(56), DPYS(22), ENTPD1(10), NT5E(4), NT5M(2), POLD1(6), POLD2(2), POLE(15), POLG(8), POLL(7), POLQ(23), POLR1B(8), POLR2A(11), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(2), RRM1(3), RRM2(2), TK2(1), TXNRD1(5), TYMS(1), UCK1(2), UMPS(1), UNG(3), UPB1(6)	19182339	257	112	241	115	164	23	11	36	23	0	0.0399	1.000	1.000
212	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	30	AKR1C4(9), AKR1D1(17), ARSB(1), ARSD(3), ARSE(5), CYP11B1(13), CYP11B2(13), HSD11B1(11), HSD11B2(2), HSD17B2(9), HSD17B3(5), HSD3B1(10), HSD3B2(10), SRD5A1(2), SRD5A2(6), STS(7), SULT1E1(12), SULT2A1(7), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(8), UGT1A9(10), UGT2B15(25), UGT2B4(31)	9103797	279	111	259	129	187	29	17	17	28	1	0.00421	1.000	1.000
213	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(15), CALM1(1), CALM2(1), ELK1(2), FCER1A(12), FCER1G(1), FOS(2), GRB2(2), HRAS(3), JUN(1), LYN(6), MAP2K1(10), MAP2K4(4), MAP2K7(4), MAP3K1(2), MAPK1(4), MAPK3(1), MAPK8(1), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PAK2(8), PIK3CA(8), PIK3R1(3), PLA2G4A(11), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAF1(8), SHC1(1), SOS1(8), SYK(14), SYT1(19), VAV1(15)	14341253	233	111	221	106	152	12	12	34	22	1	0.349	1.000	1.000
214	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(5), ACAA2(1), ACAD8(1), ACAD9(1), ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), AKR1B10(8), AKR1C4(9), AKR1D1(17), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), BAAT(10), CEL(11), CYP27A1(4), CYP7A1(8), HADHB(4), HSD3B7(3), LIPA(4), RDH11(2), RDH12(2), RDH13(3), SLC27A5(6), SOAT1(3), SOAT2(6), SRD5A1(2), SRD5A2(6)	10626059	259	111	234	119	171	28	19	23	18	0	0.00809	1.000	1.000
215	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(9), ABP1(18), ACADM(5), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), AOC2(7), AOC3(8), CNDP1(8), DPYD(56), DPYS(22), ECHS1(2), EHHADH(6), GAD1(13), GAD2(7), HADHA(8), HIBCH(1), MLYCD(2), SMS(5), UPB1(6)	9047075	215	111	200	110	142	20	13	27	13	0	0.211	1.000	1.000
216	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(8), ALOX15(8), ALOX5(8), CYP1A2(10), CYP2C18(26), CYP2C19(35), CYP2C8(30), CYP2C9(35), CYP2E1(13), CYP2J2(5), CYP3A4(19), CYP3A43(15), CYP3A5(10), CYP3A7(18), HSD3B7(3), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), RDH11(2), RDH12(2), RDH13(3)	7978158	307	111	287	173	244	12	9	14	28	0	0.0428	1.000	1.000
217	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	42	CALM1(1), CALM2(1), CD3D(5), CD3E(2), CD3G(1), ELK1(2), FOS(2), FYN(6), GRB2(2), HRAS(3), JUN(1), LAT(1), LCK(12), MAP2K1(10), MAP2K4(4), MAP3K1(2), MAPK3(1), MAPK8(1), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB1(7), NFKBIA(2), PIK3CA(8), PIK3R1(3), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(10), PTPN7(2), RAC1(17), RAF1(8), RASA1(4), RELA(4), SHC1(1), SOS1(8), SYT1(19), VAV1(15), ZAP70(8)	15938879	239	111	219	101	158	20	9	32	19	1	0.131	1.000	1.000
218	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(6), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPS(3), CDS1(9), CDS2(4), CHAT(14), CHKA(2), CHKB(3), CLC(3), CPT1B(10), DGKA(3), DGKB(22), DGKD(9), DGKE(6), DGKG(16), DGKH(8), DGKQ(6), DGKZ(7), ETNK1(4), GNPAT(2), GPD1(8), GPD2(2), LGALS13(4), LYPLA1(1), LYPLA2(1), PAFAH1B1(4), PAFAH2(2), PCYT1A(3), PCYT1B(7), PEMT(2), PISD(2), PLA2G1B(1), PLA2G2A(2), PLA2G2E(4), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PLCB2(9), PLCG1(9), PLCG2(25), PPAP2B(6), PPAP2C(8)	16691191	292	110	281	151	204	19	8	36	25	0	0.0666	1.000	1.000
219	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), AKR1B10(8), B4GALT1(2), B4GALT2(2), G6PC(5), G6PC2(4), GAA(7), GALK1(1), GALK2(2), GALT(2), GANC(5), GCK(17), GLA(1), GLB1(8), HK1(3), HK2(12), HK3(13), HSD3B7(3), LALBA(7), LCT(40), MGAM(133), PFKL(4), PFKM(1), PGM1(4), PGM3(1), RDH11(2), RDH12(2), RDH13(3), UGP2(1)	12877943	295	110	279	162	216	27	7	29	16	0	0.0736	1.000	1.000
220	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(5), AGTR2(9), CALM1(1), CALM2(1), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CDK5(4), F2(9), FYN(6), GNA11(7), GNAI1(1), GRB2(2), HRAS(3), JAK2(9), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK14(5), MAPK3(1), MAPK8(1), MAPT(10), MYLK(39), PLCG1(9), PRKCA(10), PTK2B(10), RAF1(8), SHC1(1), SOS1(8), STAT1(4), STAT3(10), STAT5A(2), SYT1(19)	13854901	229	109	213	133	143	20	11	33	22	0	0.719	1.000	1.000
221	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	11	C1QA(4), C1QB(3), C1R(13), C1S(15), C2(14), C3(46), C5(14), C6(56), C7(43), C8A(37), C9(19)	5783841	264	109	234	106	202	11	5	25	20	1	0.00301	1.000	1.000
222	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	25	ABL1(12), ATM(12), ATR(20), CCNA1(13), CCND1(1), CCNE1(4), CDC25A(8), CDK4(5), CDK6(2), CDKN1A(4), CDKN1B(1), CDKN2A(34), E2F1(5), GSK3B(2), HDAC1(1), RB1(8), SKP2(2), TFDP1(2), TGFB1(1), TGFB2(1), TGFB3(3), TP53(39)	10098379	180	109	154	44	87	7	12	22	50	2	5.28e-05	1.000	1.000
223	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(2), B4GALT2(2), FBP2(2), G6PC(5), GAA(7), GALK1(1), GALK2(2), GALT(2), GANAB(5), GCK(17), GLA(1), GLB1(8), HK1(3), HK2(12), HK3(13), LALBA(7), LCT(40), MGAM(133), PFKM(1), PGM1(4), PGM3(1)	10858696	270	108	254	145	198	27	7	25	13	0	0.0582	1.000	1.000
224	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(7), APOA1(2), CD36(4), CPT1B(10), CREBBP(20), EHHADH(6), EP300(14), FABP1(6), HSD17B4(6), JUN(1), LPL(3), MAPK1(4), MAPK3(1), ME1(19), MYC(5), NCOA1(9), NCOR1(19), NCOR2(24), NFKBIA(2), NR0B2(6), NR1H3(3), NR2F1(8), NRIP1(8), PDGFA(1), PIK3CA(8), PIK3R1(3), PPARA(6), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), PTGS2(10), RB1(8), RELA(4), RXRA(4), SP1(5), STAT5A(2), STAT5B(4), TNF(1)	21204376	275	107	267	127	178	20	18	32	24	3	0.192	1.000	1.000
225	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(5), ACAA2(1), ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH6(11), ADH7(13), ADHFE1(5), AKR1C4(9), AKR1D1(17), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2), BAAT(10), CEL(11), CYP27A1(4), CYP7A1(8), HADHB(4), SOAT2(6), SRD5A1(2), SRD5A2(6)	7803745	229	106	206	96	152	24	14	22	17	0	0.00250	1.000	1.000
226	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(3), AKT2(8), AKT3(4), ARHGEF11(17), BCL2(2), CDC42(2), DLG4(4), GNA13(1), LPA(47), MAP2K4(4), MAP3K1(2), MAP3K5(16), MAPK8(1), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PDK1(2), PHKA2(7), PI3(6), PIK3CB(21), PLD1(11), PLD2(5), PLD3(1), PTK2(8), RDX(1), ROCK1(5), ROCK2(12), SERPINA4(14), SRF(2), TBXA2R(4)	16383940	231	106	220	122	128	19	10	45	29	0	0.741	1.000	1.000
227	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(56), GABBR1(7), GPRC5A(4), GPRC5B(5), GPRC5C(8), GPRC5D(2), GRM1(16), GRM2(7), GRM3(49), GRM4(19), GRM5(13), GRM7(32), GRM8(43)	6981213	261	105	243	183	192	18	12	23	16	0	0.227	1.000	1.000
228	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(7), AADAC(14), ABAT(9), ACADS(4), ACAT2(1), ACSM1(25), AKR1B10(8), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH5A1(10), ALDH7A1(9), ALDH9A1(2), BDH1(5), DDHD1(6), ECHS1(2), EHHADH(6), GAD1(13), GAD2(7), HADHA(8), HMGCL(4), HMGCS1(2), HMGCS2(17), HSD17B10(2), HSD17B4(6), HSD3B7(3), ILVBL(4), L2HGDH(3), OXCT1(4), OXCT2(3), PDHA1(3), PDHA2(17), PDHB(1), PLA1A(9), PPME1(1), PRDX6(4), RDH11(2), RDH12(2), RDH13(3)	13600875	247	105	238	123	168	25	13	22	19	0	0.104	1.000	1.000
229	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	60	A4GALT(5), ABO(6), B3GALNT1(6), B3GALT1(11), B3GALT2(1), B3GALT4(2), B3GALT5(1), B3GNT1(2), B3GNT2(2), B3GNT3(6), B3GNT4(3), B3GNT5(1), B4GALNT1(3), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), B4GALT6(1), FUT1(3), FUT2(3), FUT3(4), FUT4(2), FUT5(6), FUT6(4), FUT7(2), FUT9(22), GBGT1(2), PIGA(2), PIGB(4), PIGC(3), PIGF(2), PIGG(10), PIGH(1), PIGK(6), PIGL(2), PIGM(2), PIGN(3), PIGO(12), PIGQ(8), PIGS(1), PIGT(1), PIGU(6), PIGV(7), PIGX(2), PIGZ(3), ST3GAL1(6), ST3GAL2(1), ST3GAL3(1), ST3GAL4(1), ST3GAL5(2), ST3GAL6(2), ST6GALNAC3(5), ST6GALNAC4(1), ST6GALNAC5(7), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(9), UGCG(1)	16171294	221	105	217	118	131	23	12	30	25	0	0.217	1.000	1.000
230	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(3), AKT2(8), AKT3(4), ANKRD6(3), APC(19), AXIN1(10), AXIN2(3), CER1(12), CSNK1A1(2), CTNNB1(11), DACT1(10), DKK1(2), DKK2(14), DKK3(4), DKK4(3), FSTL1(2), GSK3B(2), LRP1(31), MVP(10), NKD1(8), NKD2(5), PIN1(1), PSEN1(1), PTPRA(7), SENP2(11), SFRP1(2), TSHB(6), WIF1(7)	13354987	201	105	197	105	117	25	8	26	25	0	0.520	1.000	1.000
231	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(10), CFL1(1), GNAQ(4), GNAS(19), HRAS(3), LIMK1(4), MAP2K1(10), MAPK1(4), MAPK3(1), MYL2(5), NOX1(11), PIK3C2G(43), PLCB1(48), PPP1R12B(8), PRKCA(10), PTK2(8), RAF1(8), ROCK2(12)	8368659	210	104	191	83	150	7	5	31	17	0	0.0417	1.000	1.000
232	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(5), AASDHPPT(3), AASS(3), ACAT2(1), AKR1B10(8), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), BBOX1(4), DOT1L(8), ECHS1(2), EHHADH(6), EHMT1(7), EHMT2(9), GCDH(5), HADHA(8), HSD17B10(2), HSD17B4(6), HSD3B7(3), NSD1(16), OGDH(11), OGDHL(36), PIPOX(5), PLOD1(5), PLOD2(6), PLOD3(4), RDH11(2), RDH12(2), RDH13(3), SETD1A(23), SETD7(2), SETDB1(10), SHMT1(1), SHMT2(2), SUV39H1(1), SUV39H2(1), TMLHE(1)	19334304	243	104	234	115	157	22	14	33	17	0	0.120	1.000	1.000
233	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	34	BLNK(12), BTK(15), CALM1(1), CALM2(1), CD79A(2), CD79B(1), ELK1(2), FOS(2), GRB2(2), HRAS(3), JUN(1), LYN(6), MAP2K1(10), MAP3K1(2), MAPK14(5), MAPK3(1), MAPK8(1), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(10), RAC1(17), RAF1(8), SHC1(1), SOS1(8), SYK(14), SYT1(19), VAV1(15)	12772019	225	103	205	97	154	10	10	30	21	0	0.135	1.000	1.000
234	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(18), AGXT(10), AGXT2(20), ALAS1(1), ALAS2(5), AMT(1), AOC2(7), AOC3(8), BHMT(8), CBS(6), CHDH(7), CHKA(2), CHKB(3), CPT1B(10), CTH(1), DAO(10), DLD(2), DMGDH(12), GAMT(4), GARS(6), GATM(5), GCAT(4), GLDC(4), MAOA(3), MAOB(13), PEMT(2), PISD(2), PLCB2(9), PLCG1(9), PLCG2(25), PSPH(2), SARDH(19), SARS(10), SHMT1(1), SHMT2(2), TARS(2)	14067327	253	103	243	137	177	17	15	24	20	0	0.107	1.000	1.000
235	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(21), ACACB(17), ACAT2(1), ACOT12(12), ACSS1(1), ACSS2(4), AKR1B1(2), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(2), LDHA(5), LDHAL6A(4), LDHAL6B(7), LDHB(2), LDHC(5), LDHD(1), MDH1(1), MDH2(4), ME1(19), ME2(1), ME3(9), PC(12), PCK1(23), PCK2(4), PDHA1(3), PDHA2(17), PDHB(1), PKLR(11), PKM2(5)	15671151	233	103	224	124	151	18	15	32	17	0	0.265	1.000	1.000
236	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(3), ACTR3(2), AKT1(3), ANGPTL2(2), DAG1(5), DGKA(3), ETFA(2), GCA(3), ITGA9(13), ITPKB(7), ITPR1(29), ITPR2(17), ITPR3(6), MAP2K1(10), MAPK1(4), MAPK3(1), NR1I3(7), PAK1(4), PDE3A(24), PDE3B(6), PI3(6), PIK3C2G(43), PIK3CA(8), PIK3CD(7), PIK3R1(3), RIPK3(11), VASP(3)	16198453	232	103	215	93	160	18	10	22	21	1	0.00105	1.000	1.000
237	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(5), APAF1(6), ARHGDIB(3), BAG4(3), BCL2(2), BIRC2(5), BIRC3(7), CASP2(1), CASP3(2), CASP7(4), CASP8(8), CASP9(3), CFLAR(4), CHUK(2), CRADD(1), CYCS(1), DAXX(9), DFFA(2), DFFB(3), GSN(6), LMNA(8), LMNB1(2), LMNB2(4), MAP2K7(4), MAP3K1(2), MAP3K14(3), MAP3K5(16), MAPK8(1), MDM2(3), NFKB1(7), NFKBIA(2), NUMA1(8), PAK2(8), PRKCD(4), PRKDC(19), PSEN1(1), PSEN2(2), PTK2(8), RASA1(4), RB1(8), RELA(4), RIPK1(1), SPTAN1(7), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF1(6), TRAF2(2)	23135081	218	102	215	100	104	26	14	47	25	2	0.333	1.000	1.000
238	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(24), ATP4A(15), ATP4B(1), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(6), ATP5G2(1), ATP5H(1), ATP5J(2), ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A2(4), ATP6V0A4(19), ATP6V0D2(8), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), COX10(5), COX15(4), COX4I2(4), COX5B(1), COX6A1(1), COX6B1(1), COX6C(1), COX7B(1), COX7B2(2), COX8A(1), COX8C(1), CYC1(4), LHPP(1), NDUFA10(2), NDUFA12(1), NDUFA13(6), NDUFA4(1), NDUFA6(1), NDUFA9(2), NDUFAB1(1), NDUFB2(3), NDUFB3(1), NDUFB5(3), NDUFB6(2), NDUFC2(1), NDUFS2(2), NDUFS3(3), NDUFS4(3), NDUFS5(1), NDUFS6(2), NDUFS7(3), NDUFS8(3), NDUFV1(2), PPA1(1), PPA2(3), SDHA(1), SDHB(1), SDHC(2), SDHD(1), TCIRG1(3), UQCRC1(3), UQCRC2(2), UQCRFS1(2)	18756500	227	102	220	107	135	20	15	35	22	0	0.112	1.000	1.000
239	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	24	ATF2(5), BCR(10), BLNK(12), ELK1(2), FOS(2), GRB2(2), HRAS(3), JUN(1), LYN(6), MAP2K1(10), MAP3K1(2), MAPK1(4), MAPK3(1), MAPK8IP3(8), PAPPA(50), RAC1(17), RPS6KA1(6), RPS6KA3(2), SHC1(1), SOS1(8), SYK(14), VAV1(15), VAV2(3), VAV3(9)	10632679	193	102	172	113	140	12	3	20	17	1	0.716	1.000	1.000
240	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	45	ABP1(18), AGXT(10), AGXT2(20), AKR1B10(8), ALAS1(1), ALAS2(5), AMT(1), AOC2(7), AOC3(8), BHMT(8), CBS(6), CHDH(7), CHKA(2), CHKB(3), CTH(1), DAO(10), DLD(2), DMGDH(12), GAMT(4), GARS(6), GATM(5), GCAT(4), GLDC(4), GNMT(1), HSD3B7(3), MAOA(3), MAOB(13), PEMT(2), PHGDH(13), PIPOX(5), PISD(2), PSAT1(2), PSPH(2), RDH11(2), RDH12(2), RDH13(3), SARDH(19), SARS(10), SARS2(3), SDS(2), SHMT1(1), SHMT2(2), TARS(2), TARS2(7)	14298770	251	101	237	136	169	17	13	26	26	0	0.182	1.000	1.000
241	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(2), CHUK(2), DAXX(9), EGF(18), EGFR(22), ETS1(4), ETS2(8), FOS(2), HOXA7(2), HRAS(3), IKBKB(3), JUN(1), MAP2K1(10), MAP2K3(7), MAP2K4(4), MAP2K6(3), MAP2K7(4), MAP3K1(2), MAP3K14(3), MAP3K5(16), MAPK1(4), MAPK13(4), MAPK14(5), MAPK3(1), MAPK8(1), NFKB1(7), NFKBIA(2), PPP2CA(1), PRKCA(10), PRKCD(4), PRKCE(6), PRKCG(13), PRKCH(10), PRKCQ(16), RAF1(8), RELA(4), RIPK1(1), SP1(5), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF2(2)	16355749	236	101	227	147	148	20	9	37	22	0	0.933	1.000	1.000
242	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(7), EIF2B1(9), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(1), EIF2S1(1), ELAVL1(1), FLT1(33), FLT4(23), HIF1A(5), HRAS(3), KDR(42), NOS3(16), PIK3CA(8), PIK3R1(3), PLCG1(9), PRKCA(10), PTK2(8), PXN(3), SHC1(1), VHL(4)	11418226	192	101	177	98	122	16	3	25	25	1	0.447	1.000	1.000
243	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(5), AARS2(2), ABAT(9), ACY3(3), ADSL(6), ADSS(2), ADSSL1(8), AGXT(10), AGXT2(20), ASL(6), ASNS(8), ASPA(3), ASRGL1(3), ASS1(7), CAD(15), CRAT(5), DARS(4), DARS2(3), DDO(7), DLAT(2), DLD(2), GAD1(13), GAD2(7), GOT1(6), GOT2(5), GPT(3), GPT2(1), NARS(2), NARS2(5), PC(12), PDHA1(3), PDHA2(17), PDHB(1)	12689366	205	100	195	98	145	19	10	21	10	0	0.0460	1.000	1.000
244	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(6), ARG1(1), ARG2(1), ASL(6), ASS1(7), CKM(2), CKMT1A(1), CKMT2(5), CPS1(21), DAO(10), EPRS(9), GAMT(4), GATM(5), GLUD1(2), GLUD2(4), GOT1(6), GOT2(5), LAP3(1), NOS1(58), NOS3(16), OAT(3), OTC(4), P4HA1(9), P4HA2(4), P4HA3(12), PRODH(1), PYCR1(1), PYCR2(1), RARS(7), RARS2(2)	11969795	214	100	204	119	146	22	8	17	21	0	0.314	1.000	1.000
245	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(8), ALPL(9), ALPP(9), ALPPL2(11), ASCC3(10), ATP13A2(9), DDX18(4), DDX19A(1), DDX23(5), DDX4(11), DDX41(6), DDX47(1), DDX50(4), DDX51(5), DDX52(3), DDX54(2), DDX55(3), DDX56(3), DHX58(4), ENTPD7(2), EP400(22), ERCC2(2), ERCC3(4), FPGS(3), GGH(2), IFIH1(13), MOV10L1(26), NUDT5(2), NUDT8(1), QDPR(3), RAD54B(6), RUVBL2(4), SETX(17), SKIV2L2(4), SMARCA2(11), SMARCA5(5), SPR(2)	20864780	237	100	226	132	153	15	12	31	26	0	0.700	1.000	1.000
246	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(27), AR(7), ESR1(5), ESR2(6), ESRRA(2), HNF4A(18), NPM1(3), NR0B1(2), NR1D2(9), NR1H2(3), NR1H3(3), NR1I2(3), NR1I3(7), NR2C2(2), NR2E1(4), NR2F1(8), NR2F2(1), NR2F6(1), NR3C1(7), NR4A1(3), NR4A2(3), NR5A1(7), NR5A2(18), PGR(15), PPARA(6), PPARD(3), PPARG(11), RARA(3), RARB(5), RARG(2), ROR1(10), RORA(4), RORC(7), RXRA(4), RXRB(4), RXRG(5), THRA(2), THRB(14), VDR(2)	13923535	246	100	236	126	180	19	4	24	19	0	0.0944	1.000	1.000
247	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	6	C3(46), C5(14), C6(56), C7(43), C8A(37), C9(19)	4156827	215	99	189	80	168	6	4	18	18	1	0.00296	1.000	1.000
248	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(18), ACY3(3), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH7A1(9), ALDH9A1(2), AMDHD1(4), AOC2(7), AOC3(8), ASPA(3), CARM1(6), CNDP1(8), DDC(12), FTCD(2), HAL(12), HARS(6), HARS2(4), HDC(19), HEMK1(4), HNMT(1), LCMT1(4), MAOA(3), MAOB(13), METTL2B(7), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), PRPS1(2), PRPS2(3), UROC1(11), WBSCR22(1)	13210690	228	99	222	147	150	24	14	21	19	0	0.666	1.000	1.000
249	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(8), ADRA1B(3), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(2), CHRM1(5), CHRM2(18), CHRM3(19), CHRM4(6), CHRM5(4), DRD1(8), DRD2(15), DRD3(5), DRD4(1), DRD5(22), HRH1(14), HRH2(3), HTR1A(8), HTR1B(1), HTR1D(3), HTR1E(5), HTR1F(7), HTR2A(8), HTR2B(2), HTR2C(10), HTR4(9), HTR5A(16), HTR6(1), HTR7(8)	8419362	225	99	209	173	147	25	7	25	21	0	0.123	1.000	1.000
250	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(9), ALOX12(5), ALOX15(8), ALOX5(8), CBR3(1), CYP4F2(12), CYP4F3(19), EPX(7), GGT1(6), LPO(18), LTA4H(4), MPO(11), PLA2G1B(1), PLA2G2A(2), PLA2G2E(4), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PRDX1(2), PRDX2(2), PRDX6(4), PTGDS(2), PTGES2(1), PTGIS(12), PTGS1(17), PTGS2(10), TBXAS1(11), TPO(40)	9318845	253	99	247	149	192	22	3	19	17	0	0.0899	1.000	1.000
251	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	22	ARFIP2(1), CDK5(4), CFL1(1), CHN1(5), LIMK1(4), MAP3K1(2), MYL2(5), MYLK(39), NCF2(7), PAK1(4), PDGFRA(27), PIK3CA(8), PIK3R1(3), PLD1(11), PPP1R12B(8), RAC1(17), RALBP1(2), RPS6KB1(2), TRIO(18), VAV1(15), WASF1(4)	11712950	187	99	171	101	127	10	9	23	17	1	0.613	1.000	1.000
252	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	41	APAF1(6), BAX(3), BCL2(2), BIRC2(5), BIRC3(7), CASP2(1), CASP3(2), CASP7(4), CASP8(8), CASP9(3), CYCS(1), FAS(5), FASLG(14), GZMB(3), JUN(1), MAP2K4(4), MAP3K1(2), MAP3K14(3), MAPK10(8), MCL1(3), MDM2(3), MYC(5), NFKB1(7), NFKBIA(2), PARP1(8), PRF1(11), RELA(4), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TNFSF10(7), TP53(39), TRAF1(6), TRAF2(2)	12452766	187	98	181	69	105	17	15	21	29	0	0.0168	1.000	1.000
253	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(3), ADRBK2(4), ARRB2(6), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CLCA1(6), CLCA2(9), CLCA4(26), CNGA3(24), CNGA4(14), CNGB1(20), GNAL(2), GUCA1A(5), GUCA1B(2), GUCA1C(6), PDC(5), PDE1C(41), PRKACA(3), PRKACB(4), PRKACG(8), PRKG1(12), PRKG2(13), PRKX(3)	10082431	242	98	229	141	168	20	7	28	19	0	0.396	1.000	1.000
254	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(5), AARS2(2), CARS(9), CARS2(2), DARS(4), DARS2(3), EPRS(9), FARS2(4), FARSA(6), FARSB(5), GARS(6), HARS(6), HARS2(4), IARS(8), IARS2(13), KARS(4), LARS(10), LARS2(4), MARS(6), MARS2(4), MTFMT(2), NARS(2), NARS2(5), QARS(6), RARS(7), RARS2(2), SARS(10), SARS2(3), TARS(2), TARS2(7), VARS(18), VARS2(6), WARS(4), WARS2(4), YARS(1), YARS2(2)	18319729	195	97	182	97	119	21	9	25	21	0	0.385	1.000	1.000
255	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(5), CHUK(2), ELK1(2), FOS(2), IKBKB(3), IRAK1(4), JUN(1), LY96(4), MAP2K3(7), MAP2K4(4), MAP2K6(3), MAP3K1(2), MAP3K14(3), MAP3K7(1), MAPK14(5), MAPK8(1), MYD88(3), NFKB1(7), NFKBIA(2), PPARA(6), RELA(4), TIRAP(1), TLR10(11), TLR2(15), TLR3(9), TLR4(31), TLR6(5), TLR7(15), TLR9(14), TOLLIP(1), TRAF6(4)	12116932	177	97	174	88	114	17	9	23	14	0	0.261	1.000	1.000
256	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(9), ACAA1(5), ACAA2(1), ACADM(5), ACADS(4), ACAT2(1), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH6A1(3), ALDH7A1(9), ALDH9A1(2), AOX1(21), AUH(3), BCAT1(11), BCAT2(1), BCKDHA(1), BCKDHB(2), DBT(1), DLD(2), ECHS1(2), EHHADH(6), HADHA(8), HADHB(4), HIBADH(8), HIBCH(1), HMGCL(4), HMGCS1(2), HMGCS2(17), HSD17B10(2), HSD17B4(6), IVD(4), MCCC1(5), MCCC2(2), MCEE(2), MUT(5), OXCT1(4), OXCT2(3), PCCA(3), PCCB(2)	14450538	192	96	184	95	119	19	12	29	13	0	0.459	1.000	1.000
257	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(21), ACAT2(1), ADH5(3), AKR1B1(2), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(2), LDHA(5), LDHB(2), LDHC(5), LDHD(1), MDH1(1), MDH2(4), ME1(19), ME2(1), ME3(9), PC(12), PCK1(23), PDHA1(3), PDHA2(17), PDHB(1), PKLR(11), PKM2(5)	12386901	193	96	187	105	131	16	10	24	12	0	0.423	1.000	1.000
258	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(15), DLG4(4), EPHB2(29), F2(9), F2RL1(15), F2RL2(6), F2RL3(3), JUN(1), MAP2K5(3), MAPK1(4), MAPK7(4), MAPK8(1), MYEF2(4), PLD1(11), PLD2(5), PLD3(1), PTK2(8), RAF1(8), RASAL1(15), SRC(1), TEC(10), VAV1(15)	9149425	172	96	164	106	97	18	6	35	16	0	0.854	1.000	1.000
259	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	33	AGT(5), AGTR1(10), ATF2(5), CALM1(1), CALM2(1), EGFR(22), ELK1(2), GNAQ(4), GRB2(2), HRAS(3), JUN(1), MAP2K1(10), MAP2K2(3), MAP2K4(4), MAP3K1(2), MAPK1(4), MAPK3(1), MAPK8(1), MEF2A(5), MEF2B(2), MEF2C(2), MEF2D(4), PAK1(4), PRKCA(10), PTK2(8), PTK2B(10), RAC1(17), RAF1(8), SHC1(1), SOS1(8), SRC(1), SYT1(19)	11169076	180	95	157	95	121	12	7	24	16	0	0.689	1.000	1.000
260	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(4), ACTN1(5), ACTN2(21), ACTN3(7), BCAR1(4), BCR(10), CAPN1(4), CAPNS1(1), CAV1(1), CRKL(2), CSK(1), FYN(6), GRB2(2), HRAS(3), ITGA1(18), ITGB1(4), JUN(1), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), MAPK8(1), PPP1R12B(8), PTK2(8), PXN(3), RAF1(8), RAP1A(2), ROCK1(5), SHC1(1), SOS1(8), SRC(1), TLN1(12), VCL(7), ZYX(6)	15599260	182	95	174	90	104	20	8	29	20	1	0.256	1.000	1.000
261	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(18), ALDH1A3(2), ALDH3A1(5), ALDH3B1(2), ALDH3B2(7), AOC2(7), AOC3(8), DDC(12), EPX(7), ESCO1(1), ESCO2(2), GOT1(6), GOT2(5), HPD(5), LPO(18), MAOA(3), MAOB(13), MPO(11), MYST3(15), MYST4(14), NAT6(2), PNPLA3(2), PRDX6(4), SH3GLB1(2), TAT(17), TPO(40)	11460378	228	94	222	146	167	21	10	17	13	0	0.744	1.000	1.000
262	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(3), ARSE(5), B4GALT6(1), CERK(1), DEGS1(1), DEGS2(4), ENPP7(6), GAL3ST1(8), GALC(3), GBA(3), GLA(1), GLB1(8), LCT(40), NEU1(7), NEU2(14), NEU3(3), NEU4(9), PPAP2B(6), PPAP2C(8), SGMS1(15), SGMS2(1), SGPP2(6), SMPD1(3), SMPD2(1), SMPD3(8), SMPD4(5), SPHK1(1), SPHK2(7), SPTLC1(1), SPTLC2(6), UGCG(1), UGT8(7)	11837746	193	94	187	123	136	14	5	23	15	0	0.757	1.000	1.000
263	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(9), F2R(6), F2RL3(3), GNAI1(1), HRAS(3), ITGA1(18), ITGB1(4), MAP2K1(10), MAPK1(4), MAPK3(1), PLA2G4A(11), PLCB1(48), PRKCA(10), PTGS1(17), PTK2(8), RAF1(8), SRC(1), SYK(14), TBXAS1(11)	8136189	187	94	173	87	131	13	5	20	18	0	0.131	1.000	1.000
264	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(5), ACAA2(1), ACADL(4), ACADM(5), ACADS(4), ACADSB(6), ACAT2(1), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH6A1(3), ALDH9A1(2), AOX1(21), BCAT1(11), BCKDHA(1), BCKDHB(2), ECHS1(2), EHHADH(6), HADHA(8), HADHB(4), HIBADH(8), HMGCL(4), IVD(4), MCCC1(5), MCCC2(2), MCEE(2), MUT(5), OXCT1(4), PCCA(3), PCCB(2), SDS(2)	12098840	163	94	157	83	103	15	8	23	14	0	0.526	1.000	1.000
265	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(2), APC(19), ATF2(5), AXIN1(10), BMP10(13), BMP2(4), BMP4(3), BMP5(25), BMP7(2), BMPR1A(2), BMPR2(5), CHRD(14), CTNNB1(11), FZD1(4), GATA4(2), GSK3B(2), MAP3K7(1), MEF2C(2), MYL2(5), NKX2-5(1), NOG(1), NPPA(3), NPPB(5), RFC1(5), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(8), TGFBR3(6), WNT1(2)	12084133	167	93	158	84	111	15	6	16	19	0	0.609	1.000	1.000
266	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	22	ADCY1(26), AKT1(3), GNAI1(1), ITGAV(9), ITGB3(11), MAPK1(4), MAPK3(1), PDGFA(1), PDGFRA(27), PIK3CA(8), PIK3R1(3), PLCB1(48), PRKCA(10), PTK2(8), RAC1(17), SMPD1(3), SMPD2(1), SPHK1(1), SRC(1)	9208905	183	93	167	79	132	8	6	21	15	1	0.0311	1.000	1.000
267	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(22), ELK1(2), GNAS(19), GRB2(2), HRAS(3), IGF1R(10), ITGB1(4), KLK2(2), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), MKNK1(5), MKNK2(2), MYC(5), NGFR(7), PDGFRA(27), PPP2CA(1), PTPRR(24), RAF1(8), RPS6KA1(6), RPS6KA5(4), SHC1(1), SOS1(8), SRC(1), STAT3(10)	10987139	192	93	182	99	124	17	9	29	13	0	0.452	1.000	1.000
268	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(3), APC(19), AXIN1(10), CCND1(1), CD14(5), CTNNB1(11), FZD1(4), GJA1(7), GNAI1(1), GSK3B(2), IRAK1(4), LBP(8), LEF1(3), LY96(4), MYD88(3), NFKB1(7), PDPK1(4), PIK3CA(8), PIK3R1(3), PPP2CA(1), RELA(4), TIRAP(1), TLR4(31), TOLLIP(1), WNT1(2)	10153763	147	93	142	74	89	11	9	19	18	1	0.576	1.000	1.000
269	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10(4), ALG10B(4), ALG12(1), ALG13(8), ALG14(2), ALG2(4), ALG3(4), ALG5(2), ALG6(2), ALG8(6), ALG9(5), B4GALT1(2), B4GALT2(2), B4GALT3(2), DAD1(1), DDOST(2), DHDDS(1), DOLPP1(3), DPAGT1(2), DPM1(1), FUT8(8), GANAB(5), MAN1A1(15), MAN1A2(4), MAN1B1(4), MAN1C1(7), MAN2A1(10), MGAT1(3), MGAT2(2), MGAT3(10), MGAT4A(8), MGAT4B(1), MGAT5(4), MGAT5B(9), RFT1(3), RPN2(2), ST6GAL1(5), STT3B(5)	14155561	165	93	161	90	100	17	11	18	19	0	0.426	1.000	1.000
270	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	26	ALAD(5), BLVRA(2), BLVRB(1), CP(11), CPOX(4), EPRS(9), FECH(3), GUSB(3), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), PPOX(3), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(8), UGT1A9(10), UGT2B15(25), UGT2B4(31), UROS(1)	9248770	184	93	174	89	120	18	13	12	20	1	0.168	1.000	1.000
271	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(3), ACTR3(2), ARHGAP1(2), ARHGAP4(2), ARHGAP5(11), ARHGAP6(11), ARHGEF1(1), ARHGEF11(17), ARHGEF5(15), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), BAIAP2(5), CFL1(1), DIAPH1(6), GSN(6), LIMK1(4), MYL2(5), MYLK(39), OPHN1(4), PIP5K1A(6), PIP5K1B(18), PPP1R12B(8), ROCK1(5), SRC(1), TLN1(12), VCL(7)	15047378	197	93	190	94	138	13	7	25	14	0	0.0703	1.000	1.000
272	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	22	ATM(12), ATR(20), BRCA1(9), CDC25A(8), CDC25B(4), CDC25C(4), CDC34(4), CDKN1A(4), CHEK1(2), CHEK2(3), EP300(14), MDM2(3), MYT1(21), PRKDC(19), RPS6KA1(6), TP53(39), WEE1(2), YWHAQ(3)	14072473	177	92	168	61	98	13	12	25	29	0	0.0708	1.000	1.000
273	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(26), CALM1(1), CALM2(1), ELK1(2), FOS(2), GNAI1(1), GNAQ(4), GNAS(19), HRAS(3), JUN(1), MAP2K1(10), MAPK3(1), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), RAF1(8), RPS6KA3(2), SYT1(19)	11605364	198	92	186	113	131	15	10	23	19	0	0.777	1.000	1.000
274	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(4), CR1(53), CR2(32), FCGR2B(3), HLA-DRA(11), HLA-DRB1(3), ICAM1(2), ITGAL(24), ITGB2(13), PTPRC(30)	5023253	175	91	168	68	116	15	5	15	24	0	0.0339	1.000	1.000
275	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(8), EGF(18), EGFR(22), GRB2(2), HRAS(3), MAP2K1(10), MAPK1(4), MAPK3(1), PTPRB(79), RAF1(8), RASA1(4), SHC1(1), SOS1(8), SPRY1(7), SPRY2(4), SPRY3(11), SPRY4(1), SRC(1)	8348128	192	91	176	86	137	16	6	19	14	0	0.271	1.000	1.000
276	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(6), BAX(3), BCL2(2), BCL2A1(1), BCL2L2(2), CASP1(4), CASP10(4), CASP2(1), CASP3(2), CASP4(1), CASP7(4), CASP8(8), CASP9(3), CD40(4), CD40LG(2), CRADD(1), CYCS(1), DAXX(9), DFFA(2), DFFB(3), FAS(5), FASLG(14), IKBKE(9), LTA(2), MCL1(3), NFKB1(7), NFKBIA(2), NGFR(7), NR3C1(7), NTRK1(15), PTPN13(12), RIPK1(1), SFRS2IP(7), TFG(2), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF1(6), TRAF2(2), TRAF3(5), TRAF6(4)	14484803	180	90	179	99	113	15	9	22	21	0	0.757	1.000	1.000
277	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(18), ALDH1A3(2), ALDH3A1(5), ALDH3B1(2), ALDH3B2(7), AOC2(7), AOC3(8), DDC(12), EPX(7), GOT1(6), GOT2(5), HPD(5), LPO(18), MAOA(3), MAOB(13), MPO(11), PRDX1(2), PRDX2(2), PRDX6(4), TAT(17), TPO(40)	7324905	194	90	189	118	147	17	9	10	11	0	0.148	1.000	1.000
278	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(4), ANXA2(2), ANXA3(4), ANXA4(2), ANXA5(1), ANXA6(6), CYP11A1(13), EDN1(8), EDNRA(8), EDNRB(4), HPGD(1), HSD11B1(11), HSD11B2(2), PLA2G4A(11), PRL(1), PTGDR(9), PTGDS(2), PTGER2(6), PTGER4(1), PTGFR(20), PTGIR(5), PTGIS(12), PTGS1(17), PTGS2(10), S100A6(1), SCGB1A1(1), TBXAS1(11)	6837460	173	90	165	73	122	17	3	15	16	0	0.00135	1.000	1.000
279	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	15	AKT1(3), BCL2(2), EGFR(22), IGF1R(10), MYC(5), POLR2A(11), PPP2CA(1), PRKCA(10), RB1(8), TEP1(30), TERF1(2), TERT(6), TNKS(7), TP53(39), XRCC5(2)	9404833	158	90	150	75	92	10	12	18	24	2	0.206	1.000	1.000
280	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(4), CRK(2), CXCL12(2), CXCR4(3), GNAI1(1), GNAQ(4), HRAS(3), MAP2K1(10), MAPK1(4), MAPK3(1), NFKB1(7), PIK3C2G(43), PIK3CA(8), PIK3R1(3), PLCG1(9), PRKCA(10), PTK2(8), PTK2B(10), PXN(3), RAF1(8), RELA(4)	9181105	147	89	134	74	97	9	3	24	13	1	0.464	1.000	1.000
281	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ACAD9(1), ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), DHRS1(3), DHRS2(6), DHRS3(4), DHRS7(1), DHRSX(4), ESCO1(1), ESCO2(2), MYST3(15), MYST4(14), NAT6(2), PNPLA3(2), SH3GLB1(2)	8392947	169	89	150	75	119	15	6	22	7	0	0.223	1.000	1.000
282	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(5), ACTG2(4), ADCY3(3), ADCY9(9), AK1(1), ARF4(3), ARF5(1), ARL4D(2), ATP6V0A1(9), ATP6V0A2(4), ATP6V0A4(19), ATP6V0D2(8), ATP6V0E1(1), ATP6V1A(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), ERO1L(5), GNAS(19), PDIA4(4), PLCG1(9), PLCG2(25), PRKCA(10), SEC61A1(2), SEC61A2(7), TRIM23(2)	12409914	180	89	174	115	121	8	9	24	18	0	0.700	1.000	1.000
283	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	28	BCAR1(4), CALM1(1), CALM2(1), CRKL(2), GNAQ(4), GRB2(2), HRAS(3), JUN(1), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP3K1(2), MAPK1(4), MAPK14(5), MAPK3(1), MAPK8(1), PAK1(4), PLCG1(9), PRKCA(10), PTK2B(10), RAC1(17), RAF1(8), SHC1(1), SOS1(8), SRC(1), SYT1(19)	9508383	142	89	122	73	92	11	5	22	12	0	0.564	1.000	1.000
284	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(10), EEF1B2(4), EEF1D(1), EEF1G(1), EEF2(2), EEF2K(5), EIF1AX(3), EIF2AK1(3), EIF2AK2(5), EIF2AK3(17), EIF2B1(9), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(1), EIF2S1(1), EIF4A1(3), EIF4A2(3), EIF4EBP1(1), EIF4G1(13), EIF4G3(17), EIF5(1), EIF5B(2), ETF1(2), GSPT2(8), KIAA0664(4), PABPC1(5), PABPC3(9), PAIP1(7), SLC35A4(4)	14601616	146	89	135	78	70	13	12	22	29	0	0.907	1.000	1.000
285	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	21	ATM(12), ATR(20), BRCA1(9), BRCA2(19), CHEK1(2), CHEK2(3), FANCA(7), FANCC(3), FANCD2(12), FANCE(2), FANCF(1), FANCG(4), HUS1(1), MRE11A(5), RAD1(2), RAD17(5), RAD50(5), RAD9A(5), TP53(39)	14772259	156	88	148	58	93	4	10	21	28	0	0.244	1.000	1.000
286	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(3), GHR(25), GRB2(2), HRAS(3), INSR(20), IRS1(5), JAK2(9), MAP2K1(10), MAPK1(4), MAPK3(1), PIK3CA(8), PIK3R1(3), PLCG1(9), PRKCA(10), PTPN6(3), RAF1(8), RPS6KA1(6), SHC1(1), SLC2A4(8), SOS1(8), SRF(2), STAT5A(2), STAT5B(4)	11091876	154	88	144	83	93	13	7	26	14	1	0.664	1.000	1.000
287	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(16), CALCR(15), CALCRL(14), CD97(6), CRHR1(6), CRHR2(2), ELTD1(23), EMR1(27), EMR2(4), GHRHR(4), GIPR(2), GLP1R(11), GLP2R(14), GPR64(5), LPHN1(6), LPHN2(34), LPHN3(20), SCTR(7), VIPR1(4), VIPR2(5)	8798714	225	88	210	145	163	15	12	16	19	0	0.345	1.000	1.000
288	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(6), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), CYP2C19(35), CYP2C9(35), DHRS1(3), DHRS2(6), DHRS3(4), DHRS7(1), DHRSX(4), ECHS1(2), EHHADH(6), ESCO1(1), ESCO2(2), HADHA(8), MYST3(15), MYST4(14), NAT6(2), PNPLA3(2), SH3GLB1(2), YOD1(1)	10382642	181	88	169	122	120	18	9	21	13	0	0.971	1.000	1.000
289	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(5), AKT1(3), AKT2(8), AKT3(4), DAG1(5), GNAQ(4), ITPKB(7), ITPR1(29), ITPR2(17), ITPR3(6), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PDK1(2), PHKA2(7), PIK3CB(21), PITX2(4), PLD1(11), PLD2(5), PLD3(1)	14967109	160	88	152	100	78	17	13	32	20	0	0.805	1.000	1.000
290	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(3), AKT2(8), AKT3(4), CISH(3), GRB2(2), IARS(8), IL13RA1(3), IL2RG(3), IL4(1), IL4R(13), INPP5D(31), JAK1(6), JAK2(9), JAK3(6), NR0B2(6), PI3(6), PIK3CA(8), PPP1R13B(6), RPS6KB1(2), SERPINA4(14), SHC1(1), SOS1(8), SOS2(11), SRC(1), STAT6(7), TYK2(7)	12308248	177	88	171	85	116	11	9	24	17	0	0.390	1.000	1.000
291	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	21	ANPEP(17), CD2(23), CD33(17), CD5(6), CSF2(2), IFNA1(1), IFNB1(6), IFNG(2), IL10(3), IL12A(3), IL12B(3), IL13(2), IL3(3), IL4(1), IL5(4), ITGAX(18), TLR2(15), TLR4(31), TLR7(15), TLR9(14)	6203350	186	87	178	94	130	15	8	14	19	0	0.00214	1.000	1.000
292	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(11), DIAPH1(6), FYN(6), GSN(6), HRAS(3), ITGA1(18), ITGB1(4), MAP2K1(10), MAPK1(4), MAPK3(1), MYL2(5), MYLK(39), PIK3CA(8), PIK3R1(3), PTK2(8), PXN(3), RAF1(8), ROCK1(5), SHC1(1), SRC(1), TLN1(12)	12476976	162	87	149	77	106	12	5	25	13	1	0.322	1.000	1.000
293	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(34), ACE2(7), AGT(5), AGTR1(10), AGTR2(9), ANPEP(17), CMA1(5), CPA3(18), CTSA(4), CTSG(4), ENPEP(32), LNPEP(10), MAS1(3), MME(19), NLN(4), REN(9), THOP1(7)	7039142	197	87	187	101	139	17	12	12	17	0	0.0610	1.000	1.000
294	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(5), ICAM1(2), ITGA4(36), ITGAL(24), ITGAM(21), ITGB1(4), ITGB2(13), SELE(34), SELL(8), SELP(30)	5272867	177	87	168	57	135	4	5	14	19	0	0.000338	1.000	1.000
295	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), DAG1(5), ITPKB(7), ITPR1(29), ITPR2(17), ITPR3(6), NFAT5(7), PDE6A(11), PDE6B(13), PDE6C(23), PDE6D(2), PDE6G(2), SLC6A13(25), TF(11)	11911801	176	87	165	110	124	10	6	15	21	0	0.423	1.000	1.000
296	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	22	AKT1(3), EIF4A1(3), EIF4A2(3), EIF4EBP1(1), EIF4G1(13), EIF4G2(5), EIF4G3(17), GHR(25), IRS1(5), MAPK1(4), MAPK14(5), MAPK3(1), MKNK1(5), PABPC1(5), PDK2(4), PDPK1(4), PIK3CA(8), PIK3R1(3), PRKCA(10), PTEN(18), RPS6KB1(2)	9465895	144	86	136	51	76	15	10	15	27	1	0.0950	1.000	1.000
297	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(3), ACP2(2), ACP5(3), ACP6(11), ACPP(8), ALPI(8), ALPL(9), ALPP(9), ALPPL2(11), CMBL(4), CYP3A4(19), CYP3A43(15), CYP3A5(10), CYP3A7(18), DHRS1(3), DHRS2(6), DHRS3(4), DHRS7(1), DHRSX(4), PON1(14), PON2(1), PON3(5)	6005264	168	86	159	54	124	11	7	11	15	0	6.23e-06	1.000	1.000
298	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(2), EXT2(6), EXTL1(2), EXTL3(10), GLCE(8), HS2ST1(1), HS3ST1(10), HS3ST2(7), HS3ST3A1(4), HS3ST3B1(2), HS3ST5(8), HS6ST1(3), HS6ST2(2), HS6ST3(12), NDST1(4), NDST2(2), NDST3(23), NDST4(45)	6796761	151	86	146	81	98	11	5	19	18	0	0.267	1.000	1.000
299	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2)	4427039	143	86	123	53	101	14	9	13	6	0	0.00217	1.000	1.000
300	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(4), ARSB(1), FUCA1(2), GALNS(4), GBA(3), GLB1(8), GNS(2), GUSB(3), HEXA(5), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(4), HYAL1(2), HYAL2(1), IDS(9), IDUA(4), LCT(40), MAN2B1(7), MAN2B2(8), MAN2C1(3), MANBA(7), NAGLU(4), NEU1(7), NEU2(14), NEU3(3), NEU4(9), SPAM1(20)	11407574	193	86	190	98	138	15	5	19	16	0	0.169	1.000	1.000
301	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	20	B2M(5), HLA-A(6), IL18(2), ITGB1(4), KLRC1(4), KLRC2(1), KLRC3(11), KLRC4(5), KLRD1(5), LAT(1), MAP2K1(10), MAPK3(1), PAK1(4), PIK3CA(8), PIK3R1(3), PTK2B(10), PTPN6(3), RAC1(17), SYK(14), VAV1(15)	6201563	129	86	110	68	93	4	4	14	13	1	0.561	1.000	1.000
302	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	39	ATF2(5), CDC42(2), DAXX(9), DDIT3(2), ELK1(2), GRB2(2), HMGN1(2), HRAS(3), HSPB1(2), HSPB2(1), MAP2K4(4), MAP2K6(3), MAP3K1(2), MAP3K5(16), MAP3K7(1), MAP3K9(22), MAPK14(5), MAPKAPK2(7), MAPKAPK5(1), MEF2A(5), MEF2B(2), MEF2C(2), MEF2D(4), MKNK1(5), MYC(5), PLA2G4A(11), RAC1(17), RIPK1(1), RPS6KA5(4), SHC1(1), STAT1(4), TGFB1(1), TGFB2(1), TGFB3(3), TRAF2(2)	12143064	159	86	145	59	103	12	3	22	19	0	0.0814	1.000	1.000
303	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), ATF1(4), CDC42(2), CREB3(1), CREB5(9), DUSP10(6), EEF2K(5), ELK1(2), HSPB1(2), IL1R1(11), MAP2K3(7), MAP2K4(4), MAP2K6(3), MAP3K10(8), MAP3K4(17), MAP3K5(16), MAP3K7(1), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPKAPK2(7), MAPKAPK5(1), MKNK1(5), MKNK2(2), MYEF2(4), NFKB1(7), NR2C2(2), SRF(2), TRAF6(4)	11124546	150	86	145	81	95	12	3	23	17	0	0.641	1.000	1.000
304	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(9), CARM1(6), CCND1(1), CREBBP(20), EP300(14), ERCC3(4), ESR1(5), GRIP1(9), GTF2A1(2), GTF2E1(2), GTF2F1(5), HDAC1(1), HDAC2(1), HDAC3(5), HDAC4(10), HDAC5(6), HDAC6(2), MEF2C(2), NCOR2(24), NR0B1(2), NRIP1(8), PELP1(11), POLR2A(11), TBP(4)	15184305	164	85	163	84	111	6	12	24	11	0	0.597	1.000	1.000
305	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(9), ACACA(21), ACACB(17), ACADM(5), ACAT2(1), ACSS1(1), ACSS2(4), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH6A1(3), ALDH7A1(9), ALDH9A1(2), ECHS1(2), EHHADH(6), HADHA(8), HIBCH(1), LDHA(5), LDHAL6A(4), LDHAL6B(7), LDHB(2), LDHC(5), MCEE(2), MLYCD(2), MUT(5), PCCA(3), PCCB(2), SUCLG1(2), SUCLG2(2)	13332782	151	85	145	82	88	14	14	25	10	0	0.597	1.000	1.000
306	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(4), CAPN1(4), CAPN2(6), CAPNS1(1), CXCR3(4), EGF(18), EGFR(22), HRAS(3), ITGA1(18), ITGB1(4), MAPK1(4), MAPK3(1), MYL2(5), MYLK(39), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PTK2(8), PXN(3), TLN1(12)	10849171	178	85	172	106	125	11	8	19	15	0	0.536	1.000	1.000
307	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	18	AKR1B1(2), GUSB(3), UCHL1(4), UCHL3(2), UGDH(1), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(8), UGT1A9(10), UGT2B15(25), UGT2B4(31)	5931112	149	85	136	78	101	15	11	7	14	1	0.202	1.000	1.000
308	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(6), AZIN1(1), BTG1(2), CBX3(1), CLOCK(4), CRY1(7), CRY2(3), DAZAP2(1), DNAJA1(1), EIF4G2(5), ETV6(11), GFRA1(8), GSTM3(4), GSTP1(2), HERPUD1(2), HSPA8(5), IDI1(1), KLF9(2), MYF6(12), NCKAP1(5), NCOA4(4), NR1D2(9), PER1(8), PER2(11), PIGF(2), PPP1R3C(3), PPP2CB(2), PSMA4(1), PURA(3), SF3A3(4), TOB1(2), TUBB3(5), UCP3(4), UGP2(1), VAPA(1), ZFR(8)	12209248	151	84	149	67	72	14	12	32	21	0	0.652	1.000	1.000
309	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(3), CABIN1(9), CALM1(1), CALM2(1), CAMK1(4), CAMK1G(9), HDAC5(6), IGF1(11), IGF1R(10), INSR(20), MAP2K6(3), MAPK14(5), MAPK7(4), MEF2A(5), MEF2B(2), MEF2C(2), MEF2D(4), MYOD1(1), NFATC1(15), NFATC2(9), PIK3CA(8), PIK3R1(3), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYT1(19)	11648624	165	84	157	87	110	15	5	23	11	1	0.368	1.000	1.000
310	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(18), ACY1(1), ADC(5), AGMAT(3), ALDH18A1(7), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), AOC2(7), AOC3(8), ARG1(1), ARG2(1), ASL(6), ASS1(7), CPS1(21), GATM(5), MAOA(3), MAOB(13), NAGS(1), ODC1(3), OTC(4), SAT2(1), SMS(5)	9753586	152	84	147	93	91	16	12	17	16	0	0.619	1.000	1.000
311	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(9), ADC(5), ALDH4A1(6), ALDH5A1(10), CAD(15), CPS1(21), EPRS(9), GAD1(13), GAD2(7), GCLC(5), GCLM(2), GFPT1(4), GFPT2(5), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(2), GMPS(4), GOT1(6), GOT2(5), GPT(3), GPT2(1), GSR(2), GSS(7), NADSYN1(4), NAGK(1), QARS(6)	13224692	163	84	157	87	91	21	11	25	15	0	0.438	1.000	1.000
312	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(16), ANAPC10(1), ANAPC2(4), ANAPC4(4), ANAPC5(6), ANAPC7(6), BTRC(4), CDC16(1), CDC20(1), CDC23(3), CDC27(13), CUL1(5), CUL2(4), CUL3(4), FBXW11(5), FBXW7(11), FZR1(6), ITCH(7), SKP2(2), SMURF1(1), SMURF2(9), TCEB1(1), TCEB2(1), UBA1(3), UBE2D1(1), UBE2D3(3), UBE2E1(1), UBE2E2(4), UBE2E3(1), VHL(4), WWP1(3), WWP2(7)	13340391	142	84	133	60	84	4	11	23	19	1	0.562	1.000	1.000
313	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(19), AXIN1(10), CREBBP(20), CTNNB1(11), EP300(14), FZD1(4), GSK3B(2), HDAC1(1), LDB1(2), LEF1(3), PITX2(4), TRRAP(40), WNT1(2)	11122495	132	84	128	74	71	10	10	22	19	0	0.915	1.000	1.000
314	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(18), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH9A1(2), AOC2(7), AOC3(8), ASPA(3), CNDP1(8), DDC(12), HAL(12), HARS(6), HDC(19), HNMT(1), MAOA(3), MAOB(13), PRPS1(2), PRPS2(3)	8128303	162	83	158	106	108	15	10	14	15	0	0.657	1.000	1.000
315	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(2), IFNA1(1), IFNB1(6), IKBKB(3), IL1A(4), IL1B(6), IL1R1(11), IL1RAP(4), IL1RN(8), IL6(2), IRAK1(4), IRAK2(14), IRAK3(7), JUN(1), MAP2K3(7), MAP2K6(3), MAP3K1(2), MAP3K14(3), MAP3K7(1), MAPK14(5), MAPK8(1), MYD88(3), NFKB1(7), NFKBIA(2), RELA(4), TGFB1(1), TGFB2(1), TGFB3(3), TNF(1), TOLLIP(1), TRAF6(4)	9854248	122	83	119	66	75	12	4	18	13	0	0.543	1.000	1.000
316	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(9), ACACA(21), ACADL(4), ACADM(5), ACADSB(6), ACAT2(1), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH6A1(3), ALDH9A1(2), ECHS1(2), EHHADH(6), HADHA(8), LDHA(5), LDHB(2), LDHC(5), MCEE(2), MLYCD(2), MUT(5), PCCA(3), PCCB(2), SDS(2), SUCLG1(2), SUCLG2(2)	11127967	135	82	131	68	84	12	10	22	7	0	0.528	1.000	1.000
317	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(5), ABAT(9), ADSL(6), ADSS(2), AGXT(10), AGXT2(20), ASL(6), ASNS(8), ASPA(3), CAD(15), CRAT(5), DARS(4), DDO(7), GAD1(13), GAD2(7), GOT1(6), GOT2(5), GPT(3), GPT2(1), NARS(2), PC(12)	8754370	149	81	142	75	104	15	9	14	7	0	0.0799	1.000	1.000
318	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(6), BCL2(2), BIRC2(5), BIRC3(7), CASP10(4), CASP3(2), CASP7(4), CASP8(8), CASP9(3), CFLAR(4), CHUK(2), CYCS(1), DFFA(2), DFFB(3), GAS2(12), LMNA(8), MAP3K14(3), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), SPTAN1(7), TNFRSF10A(5), TNFRSF10B(2), TNFRSF25(5), TNFSF10(7), TNFSF12(1), TRAF2(2)	11180538	119	81	119	72	67	14	10	20	8	0	0.890	1.000	1.000
319	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(26), F2(9), F2R(6), FGA(38), FGB(10), FGG(7), PLAT(3), PLAU(3), PLG(30), SERPINB2(16), SERPINE1(5)	4467595	154	81	146	60	115	11	8	12	8	0	0.0486	1.000	1.000
320	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	27	ACLY(9), ACO1(5), ACO2(4), CLYBL(5), CS(2), DLD(2), FH(3), IDH1(12), IDH2(2), IDH3A(3), IDH3B(1), IDH3G(2), MDH1(1), MDH2(4), OGDH(11), OGDHL(36), PC(12), PCK1(23), PCK2(4), SDHA(1), SDHB(1), SDHC(2), SDHD(1), SUCLG1(2), SUCLG2(2)	10042419	150	81	136	72	106	4	7	19	14	0	0.0935	1.000	1.000
321	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(2), GTF2A1L(5), GTF2A2(1), GTF2B(3), GTF2E1(2), GTF2E2(5), GTF2F1(5), GTF2F2(2), GTF2H1(3), GTF2H3(1), GTF2H4(1), GTF2I(2), GTF2IRD1(8), TAF1(10), TAF13(2), TAF1L(53), TAF2(5), TAF4(8), TAF4B(2), TAF5L(3), TAF6(3), TAF6L(4), TAF7(2), TAF7L(11), TAF9(2), TAF9B(1), TBPL1(1), TBPL2(4)	12129318	151	81	147	64	102	12	6	22	9	0	0.299	1.000	1.000
322	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(24), ATP4B(1), ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(19), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), ATP7A(9), ATP7B(17), COX10(5), COX5B(1), COX6A1(1), COX6B1(1), COX6C(1), COX7B(1), COX8A(1), NDUFA10(2), NDUFA4(1), NDUFB2(3), NDUFB5(3), NDUFB6(2), NDUFS2(2), NDUFV1(2), PPA2(3), SDHA(1), SDHB(1), SHMT1(1), UQCRC1(3), UQCRFS1(2)	12844351	156	81	155	94	94	8	18	21	15	0	0.803	1.000	1.000
323	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(19), CAMP(1), CASP3(2), CERK(1), CREB3(1), CREB5(9), DAG1(5), EPHB2(29), FOS(2), GNAQ(4), ITPKB(7), JUN(1), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK8(1), MAPK8IP1(4), MAPK8IP2(7), MAPK8IP3(8), MAPK9(5)	9504529	126	81	124	68	76	8	5	17	20	0	0.706	1.000	1.000
324	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(26), CD3D(5), CD3E(2), CD3G(1), CD4(6), CREBBP(20), CSK(1), GNAS(19), HLA-DRA(11), HLA-DRB1(3), LCK(12), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PTPRC(30), ZAP70(8)	7569321	166	80	161	97	112	14	8	17	15	0	0.677	1.000	1.000
325	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(26), AKT1(3), BAX(3), BCL2(2), CSF2RB(17), IGF1(11), IGF1R(10), IL3(3), IL3RA(7), KIT(9), KITLG(8), PIK3CA(8), PIK3R1(3), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5)	7317986	132	80	128	80	85	13	7	12	14	1	0.597	1.000	1.000
326	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(7), ABAT(9), ACADS(4), ACAT2(1), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH5A1(10), ALDH9A1(2), ECHS1(2), EHHADH(6), GAD1(13), GAD2(7), HADHA(8), HMGCL(4), L2HGDH(3), OXCT1(4), PDHA1(3), PDHA2(17), PDHB(1), SDHB(1), SDS(2)	8679698	140	80	135	66	89	16	4	18	13	0	0.121	1.000	1.000
327	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(26), CD3D(5), CD3E(2), CD3G(1), CD4(6), CREBBP(20), CSK(1), GNAS(19), HLA-DRA(11), HLA-DRB1(3), LCK(12), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PTPRC(30), ZAP70(8)	7569321	166	80	161	97	112	14	8	17	15	0	0.677	1.000	1.000
328	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(3), BCL2(2), CBL(8), CFLAR(4), CRKL(2), E2F1(5), FOS(2), GRB2(2), HRAS(3), IL2RA(4), IL2RB(7), IL2RG(3), IRS1(5), JAK1(6), JAK3(6), MAPK1(4), MAPK3(1), MYC(5), NMI(1), PIK3CA(8), PIK3R1(3), PPIA(1), PTPN6(3), RAF1(8), RPS6KB1(2), SHC1(1), SOCS3(2), SOS1(8), STAT5A(2), STAT5B(4), SYK(14)	12028627	129	80	127	72	74	12	11	17	14	1	0.787	1.000	1.000
329	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(12), ABCC2(9), ABCG2(6), BCHE(6), CES1(16), CES2(4), CYP3A4(19), CYP3A5(10), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(8), UGT1A9(10)	7667525	163	80	153	76	109	14	12	11	17	0	0.0137	1.000	1.000
330	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(26), ARHGEF1(1), F2(9), F2R(6), F2RL3(3), GNA12(3), GNA13(1), GNAI1(1), GNAQ(4), MAP3K7(1), PIK3CA(8), PIK3R1(3), PLCB1(48), PPP1R12B(8), PRKCA(10), PTK2B(10), ROCK1(5)	8640233	147	80	140	77	103	10	5	17	11	1	0.401	1.000	1.000
331	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	26	ADCY1(26), AKT1(3), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), GNAS(19), GRB2(2), HRAS(3), MAPK1(4), MAPK14(5), MAPK3(1), PIK3CA(8), PIK3R1(3), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), RAC1(17), RPS6KA1(6), RPS6KA5(4), SOS1(8)	9662783	159	79	145	97	111	11	6	15	15	1	0.862	1.000	1.000
332	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(8), F2(9), F2R(6), F5(30), F7(7), FGA(38), FGB(10), FGG(7), PROC(8), PROS1(13), SERPINC1(7), TFPI(8)	5493980	151	79	140	59	102	20	9	12	8	0	0.0545	1.000	1.000
333	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK8(1), MAPK8IP1(4), MAPK8IP2(7), MAPK8IP3(8), MAPK9(5), MAPKAPK5(1), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PIK3CA(8), PIK3CD(7), PIK3R1(3), SYT1(19), TRAF2(2), TRAF3(5), TRAF5(7), TRAF6(4)	11171128	134	79	128	81	84	9	6	24	10	1	0.692	1.000	1.000
334	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	19	ABL1(12), ATM(12), BRCA1(9), CDKN1A(4), CHEK1(2), CHEK2(3), JUN(1), MAPK8(1), MDM2(3), MRE11A(5), NFKB1(7), NFKBIA(2), RAD50(5), RBBP8(3), RELA(4), TP53(39), TP73(5)	9931105	117	78	110	38	52	12	8	21	24	0	0.142	1.000	1.000
335	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(16), FOS(2), HRAS(3), JUN(1), MAP2K1(10), MAPK1(4), MAPK3(1), MYC(5), NFKB1(7), NFKBIA(2), PLCB1(48), PRKCA(10), RAF1(8), RELA(4), TNF(1)	5212313	122	78	111	49	84	8	6	14	10	0	0.0225	1.000	1.000
336	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), EGF(18), EGFR(22), ELK1(2), FOS(2), GRB2(2), HRAS(3), JAK1(6), JUN(1), MAP2K1(10), MAP2K4(4), MAP3K1(2), MAPK3(1), MAPK8(1), PIK3CA(8), PIK3R1(3), PLCG1(9), PRKCA(10), RAF1(8), RASA1(4), SHC1(1), SOS1(8), SRF(2), STAT1(4), STAT3(10), STAT5A(2)	12513816	144	78	137	78	84	14	7	25	13	1	0.893	1.000	1.000
337	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	24	POLA1(2), POLA2(8), POLD1(6), POLD2(2), POLD3(4), POLE(15), POLE2(3), POLG(8), POLG2(5), POLH(3), POLI(1), POLK(6), POLL(7), POLM(2), POLQ(23), PRIM1(3), PRIM2(15), REV1(3), REV3L(11)	13549282	127	78	125	54	70	7	7	27	16	0	0.497	1.000	1.000
338	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(3), CASP10(4), CASP3(2), CASP7(4), CASP8(8), CFLAR(4), DAXX(9), DFFA(2), DFFB(3), FAF1(7), JUN(1), LMNA(8), LMNB1(2), LMNB2(4), MAP2K4(4), MAP3K1(2), MAP3K7(1), MAPK8(1), PAK1(4), PAK2(8), PRKDC(19), PTPN13(12), RB1(8), RIPK2(2), SPTAN1(7)	13724799	129	77	129	61	58	12	10	32	15	2	0.766	1.000	1.000
339	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(9), ALDH4A1(6), ALDH5A1(10), CAD(15), CPS1(21), EPRS(9), GAD1(13), GAD2(7), GCLC(5), GCLM(2), GFPT1(4), GLS(2), GLS2(3), GLUD1(2), GLUL(2), GMPS(4), GOT1(6), GOT2(5), GPT(3), GPT2(1), GSS(7), NADSYN1(4), QARS(6)	11120950	146	77	140	70	84	16	10	23	13	0	0.256	1.000	1.000
340	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(2), ALDOB(12), ALDOC(3), FBP1(2), FBP2(2), GOT1(6), GOT2(5), GPT(3), GPT2(1), MDH1(1), MDH2(4), ME1(19), ME3(9), PGK1(4), PGK2(27), PKLR(11), PKM2(5), TKT(6), TKTL1(1), TKTL2(24)	6780089	147	77	136	78	107	14	5	12	9	0	0.0529	1.000	1.000
341	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(14), ABP1(18), AOC2(7), AOC3(8), CES1(16), CES7(14), DDHD1(6), ESCO1(1), ESCO2(2), LIPA(4), MYST3(15), MYST4(14), NAT6(2), PLA1A(9), PNPLA3(2), PPME1(1), PRDX6(4), SH3GLB1(2)	8492972	139	77	135	80	101	8	8	11	11	0	0.816	1.000	1.000
342	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(9), CCR2(16), CCR3(10), CCR4(7), CCR5(7), CCR7(3), CD28(1), CD4(6), CSF2(2), CXCR3(4), CXCR4(3), IFNG(2), IFNGR1(4), IFNGR2(4), IL12A(3), IL12B(3), IL12RB1(15), IL12RB2(3), IL18R1(17), IL2(4), IL4(1), IL4R(13), IL5(4), TGFB1(1), TGFB2(1), TGFB3(3)	6677468	146	77	139	78	104	12	1	15	14	0	0.0604	1.000	1.000
343	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(3), JAK1(6), JUN(1), MAP2K1(10), MAP2K4(4), MAP3K1(2), MAPK3(1), MAPK8(1), PDGFA(1), PDGFRA(27), PIK3CA(8), PIK3R1(3), PLCG1(9), PRKCA(10), RAF1(8), RASA1(4), SHC1(1), SOS1(8), SRF(2), STAT1(4), STAT3(10), STAT5A(2)	11651546	132	77	125	60	73	14	6	24	14	1	0.497	1.000	1.000
344	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(2), CDT1(1), DIAPH2(7), MCM10(6), MCM2(10), MCM3(10), MCM4(5), MCM5(4), MCM6(4), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), POLA2(8), POLD1(6), POLD2(2), POLD3(4), POLE(15), POLE2(3), PRIM1(3), RFC1(5), RFC2(2), RFC3(1), RPA1(3), RPA2(2), RPA3(1), RPA4(2), UBB(1), UBC(6)	16939265	129	76	128	77	77	9	5	22	16	0	0.879	1.000	1.000
345	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), AKR1B10(8), ALDOA(2), ALDOB(12), ALDOC(3), FBP1(2), FBP2(2), FPGT(2), FUK(3), GMDS(5), GMPPA(1), GMPPB(3), HK1(3), HK2(12), HK3(13), HSD3B7(3), KHK(1), LHPP(1), MPI(1), MTMR1(4), MTMR2(2), MTMR6(2), PFKFB1(4), PFKFB2(5), PFKFB3(2), PFKFB4(5), PFKL(4), PFKM(1), PGM2(6), PMM1(2), PMM2(1), RDH11(2), RDH12(2), RDH13(3), SORD(2), TSTA3(2)	12342776	128	76	124	85	86	15	10	11	6	0	0.519	1.000	1.000
346	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(5), BAIAP2(5), CASP1(4), CASP3(2), CASP7(4), CASP8(8), GAPDH(1), INSR(20), ITCH(7), MAGI1(26), MAGI2(22), RERE(21), WWP1(3), WWP2(7)	8064230	135	76	133	63	91	9	3	20	11	1	0.489	1.000	1.000
347	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(5), AASDH(5), AASDHPPT(3), AASS(3), ACAT2(1), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2), BBOX1(4), DOT1L(8), ECHS1(2), EHHADH(6), EHMT1(7), EHMT2(9), GCDH(5), HADHA(8), PLOD1(5), PLOD2(6), PLOD3(4), SDS(2), SHMT1(1), SHMT2(2), TMLHE(1)	12307643	125	76	121	73	78	14	4	20	9	0	0.623	1.000	1.000
348	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), ERCC3(4), GTF2A2(1), GTF2B(3), GTF2E1(2), GTF2E2(5), GTF2F2(2), GTF2H1(3), GTF2H4(1), MNAT1(2), POLR1A(11), POLR1B(8), POLR2A(11), POLR2B(11), POLR2C(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR3B(17), POLR3D(1), POLR3E(4), POLR3H(1), POLR3K(1), TAF13(2), TAF6(3), TAF7(2), TAF9(2), TBP(4)	11766125	111	76	108	47	65	11	8	19	8	0	0.238	1.000	1.000
349	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	21	AKT1(3), EIF4A1(3), EIF4A2(3), EIF4B(4), EIF4EBP1(1), EIF4G1(13), EIF4G2(5), EIF4G3(17), FKBP1A(2), MKNK1(5), PDK2(4), PDPK1(4), PIK3CA(8), PIK3R1(3), PPP2CA(1), PTEN(18), RPS6(1), RPS6KB1(2), TSC1(5), TSC2(11)	9259440	113	75	108	40	51	11	11	15	23	2	0.162	1.000	1.000
350	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(11), ARHGEF1(1), GNA12(3), GNA13(1), GNAQ(4), MYL2(5), MYLK(39), PLCB1(48), PPP1R12B(8), PRKCA(10), ROCK1(5)	6957125	135	75	124	61	105	4	5	13	8	0	0.160	1.000	1.000
351	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	10	ESR1(5), ESR2(6), PDE1A(35), PDE1B(12), PLCB1(48), PLCB2(9), PRL(1), TRH(4), VIP(4)	3677479	124	75	110	56	102	2	2	11	7	0	0.0311	1.000	1.000
352	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	20	AKT1(3), APAF1(6), ATM(12), BAX(3), BCL2(2), CASP3(2), CASP7(4), CASP9(3), CYCS(1), EIF2S1(1), PRKCA(10), PTK2(8), PXN(3), STAT1(4), TLN1(12), TP53(39)	9136159	113	74	105	36	56	10	8	16	23	0	0.0207	1.000	1.000
353	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(10), CSF1R(12), DDX20(8), E2F1(5), E2F4(1), ETS1(4), ETS2(8), ETV3(4), FOS(2), HDAC2(1), HDAC5(6), HRAS(3), JUN(1), NCOR2(24), RBL1(10), RBL2(4), SIN3A(9), SIN3B(7)	8690075	119	74	119	61	78	7	2	21	11	0	0.361	1.000	1.000
354	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(2), CREBBP(20), EP300(14), FYN(6), IL2RG(3), IL7(5), IL7R(27), JAK1(6), JAK3(6), LCK(12), NMI(1), PIK3CA(8), PIK3R1(3), PTK2B(10), STAT5A(2), STAT5B(4)	9325820	129	74	126	67	80	13	5	19	11	1	0.652	1.000	1.000
355	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(5), ICAM1(2), ITGA4(36), ITGAL(24), ITGB1(4), ITGB2(13), SELE(34), SELL(8)	4009140	126	74	122	39	94	4	4	9	15	0	0.00256	1.000	1.000
356	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(10), AGT(5), AGTR2(9), EDN1(8), EDNRA(8), EDNRB(4), EGF(18), EGFR(22), FOS(2), HRAS(3), JUN(1), MYC(5), NFKB1(7), PLCG1(9), PRKCA(10), RELA(4)	6869611	125	73	122	66	88	10	5	15	7	0	0.356	1.000	1.000
357	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(8), CSF1R(12), EGF(18), EGFR(22), GRB2(2), MET(19), PDGFRA(27), PRKCA(10), SH3GLB1(2), SH3GLB2(1), SH3KBP1(6), SRC(1)	6521461	128	73	127	79	86	10	6	13	13	0	0.874	1.000	1.000
358	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(1), ARSD(3), ARSE(5), GAL3ST1(8), GALC(3), GBA(3), GLA(1), GLB1(8), LCT(40), NEU1(7), NEU2(14), NEU3(3), NEU4(9), PPAP2B(6), PPAP2C(8), SMPD1(3), SMPD2(1), SPTLC1(1), SPTLC2(6), UGCG(1)	8008281	131	73	127	80	93	13	2	15	8	0	0.690	1.000	1.000
359	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	36	ANPEP(17), G6PD(3), GCLC(5), GCLM(2), GGT1(6), GPX1(7), GPX3(3), GPX5(12), GPX6(15), GSR(2), GSS(7), GSTA1(5), GSTA2(2), GSTA3(1), GSTA5(3), GSTK1(2), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTP1(2), GSTT1(1), IDH1(12), IDH2(2), MGST1(2), MGST2(2), MGST3(1), OPLAH(8), TXNDC12(1)	7305231	139	73	125	72	94	8	6	22	9	0	0.0812	1.000	1.000
360	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(2), CREBBP(20), EP300(14), IKBKB(3), IL1B(6), IL8(1), MAP2K3(7), MAP2K6(3), MAP3K14(3), MAP3K7(1), MAPK11(1), MAPK14(5), MYD88(3), NFKB1(7), NFKBIA(2), NR3C1(7), RELA(4), TGFBR2(8), TLR2(15), TNF(1)	9940107	113	73	112	64	67	15	5	19	7	0	0.872	1.000	1.000
361	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	16	ACTA1(4), ACTN1(5), ACTN2(21), ACTN3(7), CAPN1(4), CAPNS1(1), ITGA1(18), ITGB1(4), ITGB3(11), PTK2(8), PXN(3), RAC1(17), SPTAN1(7), SRC(1), TLN1(12)	9417239	123	73	112	61	83	9	5	14	11	1	0.0494	1.000	1.000
362	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CALM2(1), CHUK(2), EGR2(4), EGR3(2), GNAQ(4), MAP3K1(2), MYC(5), NFATC1(15), NFATC2(9), NFKB1(7), NFKBIA(2), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RELA(4), SYT1(19), VIP(4), VIPR2(5)	9322411	128	73	124	81	87	10	7	15	9	0	0.903	1.000	1.000
363	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(6), CHAT(14), COMT(3), DBH(13), DDC(12), GAD1(13), GAD2(7), HDC(19), MAOA(3), PAH(8), PNMT(4), SLC18A3(2), TH(9), TPH1(5)	4722413	119	72	114	73	95	9	4	3	8	0	0.233	1.000	1.000
364	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(35), ABCB11(45), ABCB4(17), ABCC1(12), ABCC3(25), GSTP1(2)	4755147	136	72	128	67	89	15	5	11	16	0	0.00784	1.000	1.000
365	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(4), GALNT10(6), GALNT2(6), GALNT3(3), GALNT4(4), GALNT6(15), GALNT7(5), GALNT8(23), GALNT9(5), GCNT1(6), ST3GAL1(6), ST3GAL2(1), ST3GAL4(1), WBSCR17(37)	4849146	122	72	114	57	92	8	4	9	9	0	0.121	1.000	1.000
366	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(4), DAB1(40), FYN(6), LRP8(3), RELN(70), VLDLR(5)	4675358	128	71	123	64	92	7	3	12	14	0	0.659	1.000	1.000
367	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(3), AKT2(8), AKT3(4), BCL2(2), GRB2(2), GSK3B(2), IL4R(13), IRS1(5), IRS2(2), JAK1(6), JAK3(6), MAP4K1(9), MAPK1(4), MAPK3(1), PDK1(2), PIK3CA(8), PIK3CD(7), PIK3R1(3), PPP1R13B(6), RAF1(8), SHC1(1), SOS1(8), SOS2(11), STAT6(7)	12211749	128	71	127	55	72	16	5	21	13	1	0.196	1.000	1.000
368	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(19), AXIN1(10), BTRC(4), CCND1(1), CREBBP(20), CSNK1A1(2), CSNK1D(1), CSNK2A1(1), CTNNB1(11), FZD1(4), GSK3B(2), HDAC1(1), MAP3K7(1), MYC(5), NLK(5), PPARD(3), PPP2CA(1), TLE1(4), WIF1(7), WNT1(2)	9761165	104	71	103	55	54	7	8	16	19	0	0.865	1.000	1.000
369	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(4), CSNK1D(1), DRD1(8), DRD2(15), GRM1(16), PLCB1(48), PPP1CA(1), PPP1R1B(2), PPP2CA(1), PPP3CA(5), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5)	5328567	123	70	117	81	95	2	6	11	9	0	0.696	1.000	1.000
370	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	30	ANPEP(17), G6PD(3), GCLC(5), GCLM(2), GGT1(6), GPX1(7), GPX3(3), GPX5(12), GSS(7), GSTA1(5), GSTA2(2), GSTA3(1), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTP1(2), GSTT1(1), IDH1(12), IDH2(2), MGST1(2), MGST2(2), MGST3(1), PGD(7)	6038720	115	70	102	49	76	6	6	19	8	0	0.0143	1.000	1.000
371	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(3), CHIA(9), CHIT1(11), CMAS(1), CTBS(8), CYB5R1(1), GFPT1(4), GFPT2(5), GNE(3), HEXA(5), HEXB(4), HK1(3), HK2(12), HK3(13), LHPP(1), MTMR1(4), MTMR2(2), MTMR6(2), NAGK(1), NANS(1), PGM3(1), RENBP(3), UAP1(2)	9585564	99	70	97	57	61	9	5	13	11	0	0.685	1.000	1.000
372	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	19	ABCB1(35), AKT1(3), ATM(12), BAX(3), CDKN1A(4), CPB2(1), CSNK1A1(2), CSNK1D(1), HIC1(1), HIF1A(5), IGFBP3(2), MAPK8(1), MDM2(3), NFKBIB(1), NQO1(1), TP53(39)	6960041	114	70	102	42	60	8	6	16	24	0	0.167	1.000	1.000
373	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(7), GBA3(14), LPO(18), MPO(11), PRDX1(2), PRDX2(2), PRDX6(4), TPO(40), TYR(8)	3233745	106	70	101	54	82	9	1	5	9	0	0.102	1.000	1.000
374	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GALNS(4), GLB1(8), GNS(2), GUSB(3), HEXA(5), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(4), HYAL1(2), HYAL2(1), IDS(9), IDUA(4), LCT(40), NAGLU(4), SPAM1(20)	6796684	126	69	123	71	93	7	2	12	12	0	0.499	1.000	1.000
375	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPAT6(2), AGPS(3), CHPT1(1), ENPP2(1), ENPP6(11), PAFAH1B1(4), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(2), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PLD1(11), PLD2(5), PPAP2B(6), PPAP2C(8)	7807121	132	69	128	72	85	11	4	17	15	0	0.489	1.000	1.000
376	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(34), AGT(5), AGTR1(10), AGTR2(9), BDKRB2(9), KNG1(11), NOS3(16), REN(9)	3307680	103	68	97	60	68	7	6	12	10	0	0.176	1.000	1.000
377	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(9), AKR1D1(17), CYP11A1(13), CYP11B1(13), CYP11B2(13), CYP17A1(7), CYP21A2(15), HSD11B1(11), HSD11B2(2), HSD3B1(10), HSD3B2(10)	3273508	120	68	109	60	83	10	5	12	10	0	0.00916	1.000	1.000
378	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(9), AKR1D1(17), CYP11A1(13), CYP11B1(13), CYP11B2(13), CYP17A1(7), CYP21A2(15), HSD11B1(11), HSD11B2(2), HSD3B1(10), HSD3B2(10)	3273508	120	68	109	60	83	10	5	12	10	0	0.00916	1.000	1.000
379	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(20), PGAP1(5), PIGA(2), PIGB(4), PIGC(3), PIGF(2), PIGG(10), PIGH(1), PIGK(6), PIGL(2), PIGM(2), PIGN(3), PIGO(12), PIGQ(8), PIGS(1), PIGT(1), PIGU(6), PIGV(7), PIGW(2), PIGX(2), PIGZ(3)	8006895	103	68	101	43	59	8	8	20	8	0	0.0744	1.000	1.000
380	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(4), ADCY1(26), CAP1(1), CDC25C(4), GNAI1(1), GNAS(19), HRAS(3), MAPK1(4), MAPK3(1), MYT1(21), PIN1(1), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RPS6KA1(6), SRC(1)	6849519	114	68	110	87	81	8	4	8	13	0	0.951	1.000	1.000
381	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	22	AKT1(3), CCND1(1), CCNE1(4), CDK4(5), CDK6(2), CDKN1A(4), CDKN1B(1), E2F1(5), HRAS(3), MAPK1(4), MAPK3(1), NFKB1(7), NFKBIA(2), PAK1(4), PIK3CA(8), PIK3R1(3), RAC1(17), RAF1(8), RB1(8), RELA(4), TFDP1(2)	6734048	96	68	85	37	49	7	6	19	12	3	0.120	1.000	1.000
382	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	21	AKT1(3), CASP9(3), CDC42(2), CHUK(2), ELK1(2), H2AFX(2), HRAS(3), MAP2K1(10), MAPK3(1), NFKB1(7), PIK3CA(8), PIK3R1(3), RAC1(17), RAF1(8), RALA(1), RALBP1(2), RALGDS(8), RELA(4), RHOA(1)	6313952	87	68	72	42	53	10	2	17	4	1	0.468	1.000	1.000
383	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	19	AKT1(3), EIF2B5(1), EIF2S1(1), EIF4EBP1(1), GSK3B(2), IGF1(11), IGF1R(10), INPPL1(15), PDK2(4), PDPK1(4), PIK3CA(8), PIK3R1(3), PPP2CA(1), PTEN(18), RPS6(1), RPS6KB1(2)	6567679	85	67	80	35	40	8	8	11	17	1	0.403	1.000	1.000
384	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(1), FOS(2), GRB2(2), HRAS(3), JAK2(9), JUN(1), MAP2K1(10), MAPK3(1), MPL(7), PIK3CA(8), PIK3R1(3), PLCG1(9), PRKCA(10), RAF1(8), RASA1(4), SHC1(1), SOS1(8), STAT1(4), STAT3(10), STAT5A(2), STAT5B(4), THPO(7)	9990156	114	67	107	52	63	11	7	22	10	1	0.591	1.000	1.000
385	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(26), ADRB2(2), CFTR(44), GNAS(19), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), SLC9A3R1(3)	4325212	116	66	109	80	80	8	6	10	12	0	0.889	1.000	1.000
386	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(18), EGFR(22), MAP2K1(10), MAP3K1(2), MAPK14(5), NCOR2(24), RARA(3), RXRA(4), THRA(2), THRB(14)	5735374	104	66	99	55	75	7	3	13	6	0	0.513	1.000	1.000
387	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(4), EPHA4(17), EPHB1(25), FYN(6), ITGA1(18), ITGB1(4), L1CAM(8), LYN(6), RAP1B(1), SELP(30)	5279238	119	66	109	65	87	4	2	16	10	0	0.539	1.000	1.000
388	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(5), CARM1(6), CBS(6), CTH(1), GGT1(6), HEMK1(4), LCMT1(4), MARS(6), MARS2(4), MAT1A(5), MAT2B(2), METTL2B(7), METTL6(2), PAPSS1(3), PAPSS2(5), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), SCLY(3), SEPHS1(4), SEPHS2(2), WBSCR22(1)	8396360	100	66	99	45	61	11	5	15	8	0	0.107	1.000	1.000
389	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(26), ADRB2(2), GNAS(19), PLCE1(48), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5)	4878055	117	66	111	71	80	9	7	11	10	0	0.724	1.000	1.000
390	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(4), DYRK1B(2), GLI2(36), GLI3(15), GSK3B(2), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), SHH(4), SMO(10), SUFU(2)	5543702	97	66	94	57	64	10	7	8	8	0	0.584	1.000	1.000
391	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(3), BAG4(3), CASP2(1), CASP3(2), CASP8(8), CRADD(1), DFFA(2), DFFB(3), JUN(1), LMNA(8), LMNB1(2), LMNB2(4), MADD(14), MAP2K4(4), MAP3K1(2), MAP3K7(1), MAPK8(1), PAK1(4), PAK2(8), PRKDC(19), RB1(8), RIPK1(1), SPTAN1(7), TNF(1), TNFRSF1A(3), TRAF2(2)	13034184	113	66	112	51	51	11	9	25	15	2	0.442	1.000	1.000
392	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM1(1), CALM2(1), CDKN1A(4), GNAQ(4), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(10), SP1(5), SP3(1), SYT1(19)	6942662	111	65	106	46	74	10	6	11	10	0	0.162	1.000	1.000
393	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(8), GABRA1(16), GABRA2(15), GABRA3(19), GABRA4(12), GABRA5(2), GABRA6(22), GPHN(7), NSF(1), SRC(1), UBQLN1(5)	3922143	108	65	96	58	81	4	5	10	7	1	0.397	1.000	1.000
394	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(2), AKT1(3), ANXA1(4), CALM1(1), CALM2(1), GNAS(19), NFKB1(7), NOS3(16), NPPA(3), NR3C1(7), PIK3CA(8), PIK3R1(3), RELA(4), SYT1(19)	5939665	97	65	90	55	71	6	2	14	3	1	0.803	1.000	1.000
395	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(3), BCL2(2), BCR(10), CRKL(2), FOS(2), GRB2(2), HRAS(3), JAK2(9), JUN(1), MAP2K1(10), MAP2K4(4), MAP3K1(2), MAPK3(1), MAPK8(1), MYC(5), PIK3CA(8), PIK3R1(3), RAF1(8), SOS1(8), STAT1(4), STAT5A(2), STAT5B(4)	9346738	94	65	88	45	50	8	6	18	11	1	0.665	1.000	1.000
396	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(2), ALDOB(12), ALDOC(3), DERA(2), FBP1(2), FBP2(2), G6PD(3), GPI(3), H6PD(5), PFKL(4), PFKM(1), PGD(7), PGLS(1), PGM1(4), PGM3(1), PRPS1(2), PRPS1L1(13), PRPS2(3), RBKS(4), TALDO1(3), TKT(6), TKTL1(1), TKTL2(24)	8105277	108	65	102	73	72	11	5	7	13	0	0.552	1.000	1.000
397	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(7), CD3D(5), CD3E(2), CD3G(1), CXCR3(4), ETV5(7), IFNG(2), IL12A(3), IL12B(3), IL12RB1(15), IL12RB2(3), IL18(2), IL18R1(17), JAK2(9), JUN(1), MAP2K6(3), MAPK14(5), MAPK8(1), STAT4(22), TYK2(7)	6206349	119	65	116	59	81	8	4	15	11	0	0.446	1.000	1.000
398	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(3), IL2(4), IL2RA(4), IL2RB(7), IL2RG(3), JAK1(6), JAK3(6), JUN(1), LCK(12), MAP2K1(10), MAPK3(1), MAPK8(1), RAF1(8), SHC1(1), SOS1(8), STAT5A(2), STAT5B(4), SYK(14)	7690955	102	65	96	49	63	9	5	16	9	0	0.337	1.000	1.000
399	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CALM2(1), CAMK1(4), CAMK1G(9), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CAMK4(10), ESRRA(2), HDAC5(6), MEF2A(5), MEF2B(2), MEF2C(2), MEF2D(4), PPARA(6), PPP3CA(5), PPP3CB(4), PPP3CC(2), SLC2A4(8), SYT1(19)	6706586	108	65	101	64	80	6	3	11	8	0	0.529	1.000	1.000
400	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(3), PIK3CA(8), PIK3R1(3), PLCB1(48), PLCG1(9), PRKCA(10), VAV1(15)	4303263	96	65	90	49	76	3	2	8	6	1	0.386	1.000	1.000
401	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(4), FUCA1(2), GLB1(8), HEXA(5), HEXB(4), LCT(40), MAN2B1(7), MAN2B2(8), MAN2C1(3), MANBA(7), NEU1(7), NEU2(14), NEU3(3), NEU4(9)	6782316	121	64	119	59	90	11	3	12	5	0	0.145	1.000	1.000
402	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(7), GBA(3), GBA3(14), LPO(18), MPO(11), PRDX6(4), TPO(40)	2807448	97	64	92	52	76	8	1	5	7	0	0.102	1.000	1.000
403	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(4), CS(2), DLAT(2), DLD(2), FH(3), IDH2(2), IDH3A(3), IDH3B(1), IDH3G(2), MDH1(1), MDH2(4), OGDH(11), PC(12), PDHA1(3), PDHA2(17), PDHB(1), PDHX(2), PDK1(2), PDK2(4), PDK3(4), PDK4(8), PDP2(5), SDHA(1), SDHB(1), SDHC(2), SDHD(1), SUCLG1(2), SUCLG2(2)	9528058	104	64	100	47	70	5	6	11	12	0	0.178	1.000	1.000
404	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(2), IKBKB(3), IL1A(4), IL1R1(11), IRAK1(4), MAP3K1(2), MAP3K14(3), MAP3K7(1), MYD88(3), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), TLR4(31), TNF(1), TNFAIP3(2), TNFRSF1A(3), TNFRSF1B(3), TRAF6(4)	8015050	91	64	88	58	62	6	5	10	8	0	0.862	1.000	1.000
405	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(4), GTF2A1(2), GTF2B(3), GTF2E1(2), GTF2F1(5), HDAC3(5), NCOA1(9), NCOA2(13), NCOA3(14), NCOR2(24), POLR2A(11), RARA(3), RXRA(4), TBP(4)	8309508	103	64	101	47	78	3	5	10	7	0	0.240	1.000	1.000
406	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(2), ALDOB(12), ALDOC(3), FBP1(2), FBP2(2), FPGT(2), GCK(17), GMDS(5), GMPPA(1), GMPPB(3), HK1(3), HK2(12), HK3(13), KHK(1), MPI(1), PFKFB1(4), PFKFB3(2), PFKFB4(5), PFKM(1), PMM1(2), PMM2(1), SORD(2)	7964637	98	63	93	68	71	13	6	4	4	0	0.433	1.000	1.000
407	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(11), BCAT2(1), IARS(8), IARS2(13), ILVBL(4), LARS(10), LARS2(4), PDHA1(3), PDHA2(17), PDHB(1), VARS(18), VARS2(6)	6323882	96	63	86	41	61	11	3	12	9	0	0.197	1.000	1.000
408	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	18	ACTA1(4), ACTR2(3), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), NCK1(1), NCKAP1(5), NTRK1(15), PIR(1), RAC1(17), WASF1(4), WASF2(4), WASF3(12), WASL(5)	5126298	79	62	69	28	55	5	2	10	7	0	0.156	1.000	1.000
409	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(26), GNAS(19), PPP2CA(1), PRKAA1(1), PRKAA2(24), PRKAB1(2), PRKAB2(2), PRKACB(4), PRKACG(8), PRKAG1(2), PRKAG2(7), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5)	5103428	106	62	101	63	75	8	7	4	12	0	0.729	1.000	1.000
410	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(1), ERBB4(47), NRG2(7), NRG3(20), PRKCA(10), PSEN1(1)	2982990	86	62	78	31	67	4	2	5	8	0	0.0376	1.000	1.000
411	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(16), GABRA2(15), GABRA3(19), GABRA4(12), GABRA5(2), GABRA6(22), GPX1(7), PRKCE(6)	2582029	99	62	85	49	71	5	3	12	7	1	0.249	1.000	1.000
412	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(10), CYP2A13(11), CYP2A6(11), CYP2A7(8), NAT1(2), NAT2(9), XDH(50)	2690942	101	62	95	60	80	4	8	4	5	0	0.0660	1.000	1.000
413	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(21), BST1(1), CD38(4), ENPP1(11), ENPP3(14), NADK(4), NADSYN1(4), NMNAT2(3), NMNAT3(8), NNMT(9), NNT(3), NT5C1A(3), NT5C1B(22), NT5C2(3), NT5C3(2), NT5E(4), NT5M(2), NUDT12(1), QPRT(6)	7215895	125	62	121	66	81	10	6	13	15	0	0.505	1.000	1.000
414	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(8), ASRGL1(3), CA1(8), CA12(3), CA13(5), CA2(9), CA3(5), CA4(3), CA5A(2), CA5B(1), CA6(4), CA7(1), CA8(4), CA9(8), CPS1(21), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(2), HAL(12)	7049279	112	62	110	49	77	8	4	13	10	0	0.125	1.000	1.000
415	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(3), CAT(5), EPX(7), LPO(18), MPO(11), PRDX1(2), PRDX2(2), PRDX6(4), SHMT1(1), SHMT2(2), TPO(40)	3961561	95	62	92	53	74	8	1	7	5	0	0.171	1.000	1.000
416	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(34), CD44(5), CSF1(10), FCGR3A(8), IL1B(6), IL6R(4), SELL(8), SPN(5), TGFB1(1), TGFB2(1), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TNFRSF8(17), TNFSF8(3)	4327349	109	62	103	46	81	5	6	5	12	0	0.0227	1.000	1.000
417	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	16	AKT1(3), AKT2(8), AKT3(4), GRB2(2), MAPK1(4), MAPK3(1), PDK1(2), PIK3CA(8), PIK3CD(7), PTEN(18), PTK2B(10), RBL2(4), SHC1(1), SOS1(8)	6864583	80	62	77	34	37	6	3	17	17	0	0.557	1.000	1.000
418	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(3), CNR1(9), CNR2(4), DNMT1(18), MTNR1A(8), MTNR1B(7), PTAFR(2), PTGDR(9), PTGER2(6), PTGER4(1), PTGFR(20), PTGIR(5), TBXA2R(4)	3730498	96	62	91	70	64	12	5	7	8	0	0.330	1.000	1.000
419	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(19), CDH1(5), CREBBP(20), EP300(14), MAP2K1(10), MAP3K7(1), MAPK3(1), SKIL(2), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(8)	8611661	85	62	80	42	48	8	3	14	12	0	0.865	1.000	1.000
420	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(5), CARS(9), DARS(4), EPRS(9), FARS2(4), GARS(6), HARS(6), IARS(8), KARS(4), LARS(10), LARS2(4), MARS(6), MARS2(4), NARS(2), QARS(6), RARS(7), SARS(10), TARS(2), WARS(4), WARS2(4), YARS(1)	10796818	115	61	109	46	71	12	6	16	10	0	0.106	1.000	1.000
421	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(5), ACTN2(21), ACTN3(7), BCAR1(4), CSK(1), CTNNA1(2), CTNNA2(23), CTNNB1(11), PTK2(8), PXN(3), SRC(1), VCL(7)	6309423	93	61	90	51	58	7	4	13	10	1	0.296	1.000	1.000
422	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(7), GSR(2), GSS(7), IL8(1), NFKB1(7), NOX1(11), RELA(4), TNF(1), XDH(50)	3303517	90	61	85	39	66	6	4	10	4	0	0.0406	1.000	1.000
423	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(3), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K6(3), MAP3K1(2), MAPK1(4), MAPK14(5), MAPK3(1), NFKB1(7), PIK3CA(8), PIK3R1(3), RB1(8), RELA(4), SP1(5)	6463992	73	61	66	39	36	7	3	13	11	3	0.854	1.000	1.000
424	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(3), IGF1(11), IGF1R(10), IRS1(5), JUN(1), MAP2K1(10), MAPK3(1), MAPK8(1), PIK3CA(8), PIK3R1(3), PTPN11(9), RAF1(8), RASA1(4), SHC1(1), SOS1(8), SRF(2)	8280583	92	61	83	42	46	16	2	19	8	1	0.622	1.000	1.000
425	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(3), INSR(20), IRS1(5), JUN(1), MAP2K1(10), MAPK3(1), MAPK8(1), PIK3CA(8), PIK3R1(3), PTPN11(9), RAF1(8), RASA1(4), SHC1(1), SLC2A4(8), SOS1(8), SRF(2)	8565014	99	61	91	46	46	14	3	25	10	1	0.695	1.000	1.000
426	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(9), CALM1(1), CALM2(1), CAPN2(6), CAPNS1(1), EP300(14), HDAC1(1), HDAC2(1), MEF2D(4), NFATC1(15), NFATC2(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(10), SYT1(19)	8210132	102	61	97	45	70	7	7	10	8	0	0.223	1.000	1.000
427	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(5), ICAM1(2), ITGAL(24), ITGAM(21), ITGB2(13), SELE(34), SELL(8)	3432646	107	61	107	40	78	4	3	7	15	0	0.00503	1.000	1.000
428	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(21), CPT1A(10), LEP(2), LEPR(22), PRKAA1(1), PRKAA2(24), PRKAB1(2), PRKAB2(2), PRKAG1(2), PRKAG2(7)	4890702	93	60	87	47	65	5	4	6	13	0	0.585	1.000	1.000
429	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	15	CCR5(7), CD2(23), CD3D(5), CD3E(2), CD3G(1), CD4(6), CXCR3(4), IFNG(2), IL12A(3), IL12B(3), IL12RB1(15), IL12RB2(3), JAK2(9), STAT4(22), TYK2(7)	4863570	112	60	106	56	73	11	4	13	11	0	0.271	1.000	1.000
430	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	22	AKT1(3), AP2A1(1), AP2M1(3), BTK(15), EEA1(2), GRASP(1), GSK3B(2), LYN(6), PDPK1(4), PFKL(4), PFKM(1), PLCG1(9), PRKCE(6), PRKCZ(5), RAB5A(1), RAC1(17), RPS6KB1(2), VAV2(3)	8266581	85	60	74	45	53	5	5	12	10	0	0.247	1.000	1.000
431	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	20	ACO1(5), ACO2(4), CS(2), DLD(2), FH(3), IDH1(12), IDH2(2), IDH3A(3), IDH3B(1), IDH3G(2), MDH1(1), MDH2(4), PC(12), PCK1(23), SDHA(1), SDHB(1), SUCLG1(2), SUCLG2(2)	6944457	82	59	71	46	60	1	6	9	6	0	0.459	1.000	1.000
432	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(1), ATG5(2), ATG7(8), BECN1(3), GABARAPL1(1), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(9), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(5), IFNA8(3), IFNG(2), PIK3C3(3), PIK3R4(6), PRKAA1(1), PRKAA2(24), ULK1(7), ULK2(6), ULK3(1)	6983276	108	59	104	57	76	7	6	13	6	0	0.429	1.000	1.000
433	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(3), IL6(2), IL6R(4), IL6ST(10), JAK1(6), JAK2(9), JAK3(6), JUN(1), MAP2K1(10), MAPK3(1), PTPN11(9), RAF1(8), SHC1(1), SOS1(8), SRF(2), STAT3(10)	7952718	97	59	90	46	44	12	4	25	12	0	0.735	1.000	1.000
434	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(4), FUCA1(2), GLB1(8), HEXA(5), HEXB(4), LCT(40), MAN2C1(3), MANBA(7), NEU1(7), NEU2(14), NEU3(3), NEU4(9)	5505885	106	59	104	52	79	9	2	11	5	0	0.255	1.000	1.000
435	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(15), AP2A1(1), AP2M1(3), BIN1(4), CALM1(1), CALM2(1), DNM1(8), EPN1(6), EPS15(3), PICALM(1), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYNJ1(20), SYNJ2(15), SYT1(19)	7152216	108	59	103	53	76	9	2	16	5	0	0.386	1.000	1.000
436	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(2), ALDOB(12), ALDOC(3), FBP1(2), FBP2(2), GOT1(6), GOT2(5), GPT(3), GPT2(1), MDH1(1), MDH2(4), ME1(19), ME2(1), ME3(9), PGK1(4), PKLR(11), PKM2(5), TKT(6)	6057530	96	58	93	49	68	8	5	7	8	0	0.0980	1.000	1.000
437	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD3D(5), CD3E(2), CD3G(1), CD80(4), CD86(19), CTLA4(2), GRB2(2), HLA-DRA(11), HLA-DRB1(3), ICOS(3), IL2(4), ITK(20), LCK(12), PIK3CA(8), PIK3R1(3), PTPN11(9)	4276366	109	58	104	42	73	8	1	15	11	1	0.177	1.000	1.000
438	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(5), BHMT(8), CBS(6), CTH(1), DNMT1(18), DNMT3A(5), DNMT3B(9), MARS(6), MARS2(4), MAT1A(5), MAT2B(2), MTAP(4), MTFMT(2), MTR(9), TAT(17)	7024338	101	58	99	40	65	6	8	12	10	0	0.0494	1.000	1.000
439	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(3), CAT(5), EPX(7), LPO(18), MPO(11), MTHFR(1), PRDX6(4), SHMT1(1), SHMT2(2), TPO(40)	3913525	92	58	89	53	72	8	1	7	4	0	0.206	1.000	1.000
440	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(17), FOS(2), GRB2(2), HRAS(3), IL3(3), IL3RA(7), JAK2(9), MAP2K1(10), MAPK3(1), PTPN6(3), RAF1(8), SHC1(1), SOS1(8), STAT5A(2), STAT5B(4)	5870810	80	58	75	40	47	4	4	14	11	0	0.564	1.000	1.000
441	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(8), CA1(8), CA12(3), CA2(9), CA3(5), CA4(3), CA5A(2), CA5B(1), CA6(4), CA7(1), CA8(4), CA9(8), CPS1(21), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUL(2), HAL(12)	6302036	100	58	98	44	69	6	3	13	9	0	0.148	1.000	1.000
442	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	7	ATM(12), ATR(20), CDC25C(4), CHEK1(2), CHEK2(3), TP53(39)	5356795	80	58	73	22	43	2	7	9	19	0	0.0744	1.000	1.000
443	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(11), APOA1(2), APOA4(7), APOC1(2), APOC2(1), APOE(1), CETP(7), CYP7A1(8), DGAT1(1), HMGCR(12), LDLR(14), LIPC(8), LPL(3), LRP1(31), SCARB1(4), SOAT1(3)	9257646	115	58	113	66	68	13	7	15	12	0	0.443	1.000	1.000
444	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(23), CD28(1), CD3D(5), CD3E(2), CD3G(1), CD8A(2), ICAM1(2), ITGAL(24), ITGB2(13), PTPRC(30), THY1(1)	3550351	104	58	97	46	73	7	2	7	15	0	0.0335	1.000	1.000
445	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	11	CD2(23), CD28(1), CD3D(5), CD3E(2), CD3G(1), CD4(6), ICAM1(2), ITGAL(24), ITGB2(13), PTPRC(30), THY1(1)	3721902	108	58	101	52	75	8	2	8	15	0	0.0733	1.000	1.000
446	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(5), ALOX15(8), ALOX15B(8), ALOX5(8), ALOX5AP(1), DPEP1(4), GGT1(6), LTA4H(4), PLA2G2A(2), PLA2G6(9), PTGDS(2), PTGIS(12), PTGS1(17), PTGS2(10), TBXAS1(11)	4989446	107	57	104	68	77	9	2	11	8	0	0.258	1.000	1.000
447	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(6), BIRC2(5), BIRC3(7), CASP10(4), CASP3(2), CASP7(4), CASP8(8), CASP9(3), DFFA(2), DFFB(3), GZMB(3), PRF1(11), SCAP(8), SREBF1(5), SREBF2(8)	6091199	79	57	77	38	47	7	7	11	7	0	0.408	1.000	1.000
448	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(11), POLR1B(8), POLR1C(1), POLR2A(11), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(4), POLR3B(17), POLR3G(1), POLR3GL(1), POLR3H(1), POLR3K(1)	7866598	77	56	75	32	42	10	6	12	7	0	0.200	1.000	1.000
449	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(2), ALDOB(12), ALDOC(3), FBP1(2), FBP2(2), G6PD(3), GPI(3), H6PD(5), PFKM(1), PGD(7), PGLS(1), PGM1(4), PGM3(1), PRPS1(2), PRPS1L1(13), PRPS2(3), RBKS(4), TAL1(6), TALDO1(3), TKT(6)	6828679	83	56	80	60	54	7	5	6	11	0	0.756	1.000	1.000
450	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	16	AKT1(3), BCAR1(4), CDKN1B(1), GRB2(2), ITGB1(4), MAPK1(4), MAPK3(1), PDK2(4), PDPK1(4), PIK3CA(8), PIK3R1(3), PTEN(18), PTK2(8), SHC1(1), SOS1(8)	6404835	73	56	69	30	35	5	3	13	16	1	0.629	1.000	1.000
451	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(3), BIRC2(5), BIRC3(7), CASP3(2), CASP8(8), CFLAR(4), JUN(1), MAP2K4(4), MAP3K3(6), MAP3K7(1), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), NR2C2(2), RALBP1(2), RIPK1(1), TNF(1), TNFAIP3(2), TNFRSF1A(3), TNFRSF1B(3), TRAF2(2)	9040643	78	56	78	49	39	6	9	18	6	0	0.928	1.000	1.000
452	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(19), HLA-DRA(11), HLA-DRB1(3), IFNG(2), IFNGR1(4), IFNGR2(4), IL12A(3), IL12B(3), IL12RB1(15), IL12RB2(3), IL18(2), IL18R1(17), IL2(4), IL2RA(4), IL4(1), IL4R(13)	4235648	109	56	105	46	80	6	0	9	14	0	0.0898	1.000	1.000
453	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(3), CHRNB1(1), CHRNG(2), MUSK(33), PIK3CA(8), PIK3R1(3), PTK2(8), PTK2B(10), RAPSN(1), SRC(1), TERT(6)	5435909	76	54	72	64	51	4	1	14	5	1	0.981	1.000	1.000
454	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	14	ACTR2(3), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(2), PAK1(4), PDGFRA(27), PIK3CA(8), PIK3R1(3), RAC1(17), WASL(5)	4503341	77	54	67	24	53	3	2	10	8	1	0.0635	1.000	1.000
455	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	21	ABO(6), B3GNT1(2), B3GNT2(2), B3GNT3(6), B3GNT4(3), B3GNT5(1), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), FUT1(3), FUT2(3), FUT3(4), FUT4(2), FUT5(6), FUT6(4), FUT7(2), FUT9(22), ST3GAL6(2), ST8SIA1(1)	5333543	78	54	76	37	49	10	4	6	9	0	0.109	1.000	1.000
456	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(4), ALG5(2), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT5(2), DDOST(2), DPAGT1(2), DPM1(1), FUT8(8), MAN1A1(15), MAN1B1(4), MGAT1(3), MGAT2(2), MGAT3(10), MGAT4A(8), MGAT4B(1), MGAT5(4), RPN2(2), ST6GAL1(5)	6688657	81	54	80	50	51	9	3	10	8	0	0.668	1.000	1.000
457	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(5), CD3E(2), CD3G(1), CD4(6), FYN(6), HLA-DRA(11), HLA-DRB1(3), LCK(12), PTPRC(30), ZAP70(8)	2953976	84	54	81	36	57	8	2	9	8	0	0.109	1.000	1.000
458	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(6), CREBBP(20), EP300(14), NCOA3(14), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RARA(3), RXRA(4)	6930703	83	53	83	45	52	4	4	14	9	0	0.827	1.000	1.000
459	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(6), ARHGDIB(3), BIRC2(5), BIRC3(7), CASP1(4), CASP10(4), CASP2(1), CASP3(2), CASP4(1), CASP7(4), CASP8(8), CASP9(3), CYCS(1), DFFA(2), DFFB(3), GZMB(3), LMNA(8), LMNB1(2), LMNB2(4), PRF1(11)	6551792	82	53	82	34	44	11	6	15	6	0	0.294	1.000	1.000
460	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(6), POLD2(2), POLE(15), POLG(8), POLL(7), POLQ(23)	5596894	61	53	60	26	33	5	2	12	9	0	0.256	1.000	1.000
461	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(4), CYSLTR2(2), GPR109B(7), GPR161(7), GPR171(9), GPR18(5), GPR34(2), GPR39(10), GPR45(6), GPR65(10), GPR68(3), GPR75(5), GPR81(4)	3269975	74	53	72	37	53	3	4	6	8	0	0.00728	1.000	1.000
462	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), B4GALNT1(3), GLB1(8), HEXA(5), HEXB(4), LCT(40), SLC33A1(5), ST3GAL1(6), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(5), ST6GALNAC4(1), ST6GALNAC5(7), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(9)	5516662	101	53	99	62	72	9	1	13	6	0	0.581	1.000	1.000
463	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(4), CASP2(1), CHUK(2), CRADD(1), IKBKB(3), JUN(1), LTA(2), MAP2K3(7), MAP2K4(4), MAP2K6(3), MAP3K1(2), MAP3K14(3), MAP4K2(6), MAPK14(5), MAPK8(1), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), TNF(1), TNFRSF1A(3), TRAF2(2)	7951248	65	53	65	45	37	10	2	10	6	0	0.924	1.000	1.000
464	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), ELK1(2), EPO(5), EPOR(1), FOS(2), GRB2(2), HRAS(3), JAK2(9), JUN(1), MAP2K1(10), MAPK3(1), MAPK8(1), PLCG1(9), PTPN6(3), RAF1(8), SHC1(1), SOS1(8), STAT5A(2), STAT5B(4)	7124992	73	52	68	39	38	5	6	16	8	0	0.782	1.000	1.000
465	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(3), CAT(5), GH1(3), GHR(25), HRAS(3), IGF1(11), IGF1R(10), PIK3CA(8), PIK3R1(3), SHC1(1)	4439322	72	52	68	38	50	9	0	8	4	1	0.556	1.000	1.000
466	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(21), CD38(4), ENPP1(11), ENPP3(14), NADSYN1(4), NMNAT2(3), NNMT(9), NNT(3), NT5E(4), NT5M(2), QPRT(6)	4881343	81	52	77	38	51	8	4	9	9	0	0.317	1.000	1.000
467	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(20), EP300(14), LPL(3), NCOA1(9), NCOA2(13), PPARG(11), RXRA(4)	6228414	74	52	72	29	49	4	3	11	7	0	0.374	1.000	1.000
468	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(26), FHL5(12), FSHB(4), FSHR(15), GNAS(19), XPO1(2)	3165348	78	51	75	50	58	5	4	5	6	0	0.843	1.000	1.000
469	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(7), ASPH(3), COPS5(3), EDN1(8), EP300(14), EPO(5), HIF1A(5), JUN(1), LDHA(5), NOS3(16), P4HB(2), VHL(4)	5725124	73	51	71	32	45	3	5	10	10	0	0.469	1.000	1.000
470	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(3), GRB2(2), HRAS(3), IGF1R(10), IRS1(5), MAP2K1(10), MAPK1(4), MAPK3(1), PIK3CA(8), PIK3R1(3), RAF1(8), SHC1(1), SOS1(8)	6366236	66	51	60	31	36	8	2	12	7	1	0.565	1.000	1.000
471	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(1), APC(19), AXIN1(10), BTRC(4), CTNNB1(11), DLL1(2), FZD1(4), GSK3B(2), NOTCH1(6), PSEN1(1), WNT1(2)	7051430	62	51	62	38	30	7	4	7	14	0	0.908	1.000	1.000
472	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(1), ALDH18A1(7), ARG1(1), ARG2(1), ASL(6), CKM(2), CKMT1A(1), CKMT2(5), CPS1(21), GAMT(4), GATM(5), GLUD1(2), NAGS(1), OAT(3), ODC1(3), OTC(4), PYCR1(1), SMS(5)	5779297	73	51	71	31	42	8	3	11	9	0	0.145	1.000	1.000
473	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(3), BCL2(2), CASP8(8), CYCS(1), MAP2K1(10), MAP2K4(4), MAP3K1(2), MAPK1(4), MAPK3(1), MAPK8(1), NFKB1(7), NSMAF(4), RAF1(8), RELA(4), RIPK1(1), SMPD1(3), TNFRSF1A(3), TRAF2(2)	6817640	68	50	63	31	38	6	3	13	8	0	0.504	1.000	1.000
474	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(21), ACACB(17), FASN(17), MCAT(2), OLAH(11), OXSM(2)	5287659	70	50	69	37	43	6	3	9	9	0	0.295	1.000	1.000
475	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(6), CSF1(10), CSF2(2), CSF3(4), HLA-DRA(11), HLA-DRB1(3), IFNA1(1), IFNB1(6), IFNG(2), IL10(3), IL11(2), IL12A(3), IL12B(3), IL13(2), IL15(3), IL1A(4), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(5), IL8(1), LTA(2), PDGFA(1), TGFB1(1), TGFB2(1), TGFB3(3), TNF(1)	4398114	94	50	93	49	63	7	3	9	12	0	0.0504	1.000	1.000
476	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(5), BHMT(8), CBS(6), CTH(1), DNMT1(18), DNMT3A(5), DNMT3B(9), MARS(6), MARS2(4), MAT1A(5), MAT2B(2), MTR(9)	5913932	78	50	77	26	49	4	7	10	8	0	0.0158	1.000	1.000
477	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(3), IL6(2), IL6R(4), JAK1(6), JAK2(9), JAK3(6), PIAS3(5), PTPRU(15), REG1A(7), SRC(1), STAT3(10)	5079781	68	50	68	40	37	6	3	12	10	0	0.659	1.000	1.000
478	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(5), GNAQ(4), HTR2C(10), PLCB1(48), TUB(9)	2391755	76	50	71	36	62	1	1	7	5	0	0.129	1.000	1.000
479	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(11), CYP11A1(13), CYP11B2(13), CYP17A1(7), HSD11B1(11), HSD11B2(2), HSD3B1(10), HSD3B2(10)	2308336	77	49	73	51	57	6	1	6	7	0	0.122	1.000	1.000
480	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(5), ACOX1(7), ACOX3(11), ELOVL2(2), ELOVL5(1), ELOVL6(2), FADS2(3), FASN(17), HADHA(8), HSD17B12(2), PECR(1), SCD(3)	4781218	62	49	62	29	40	4	2	9	7	0	0.0857	1.000	1.000
481	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(1), DPM2(1), ELK1(2), FOS(2), GRB2(2), HRAS(3), JUN(1), KLK2(2), MAP2K1(10), MAPK3(1), MAPK8(1), NGFR(7), PIK3CA(8), PIK3R1(3), PLCG1(9), RAF1(8), SHC1(1), SOS1(8)	6362295	70	49	64	35	40	7	2	15	5	1	0.722	1.000	1.000
482	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(19), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), FDXR(8), SHMT1(1)	5371570	77	49	76	43	43	4	6	14	10	0	0.486	1.000	1.000
483	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(3), CASP9(3), CHUK(2), GH1(3), GHR(25), NFKB1(7), NFKBIA(2), PDPK1(4), PIK3CA(8), PIK3R1(3), PPP2CA(1), RELA(4)	4679510	65	48	61	38	43	6	3	8	4	1	0.832	1.000	1.000
484	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(19), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), SHMT1(1)	5049345	69	48	68	39	38	3	6	13	9	0	0.546	1.000	1.000
485	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CALM2(1), CCL2(1), CCR5(7), CXCL12(2), CXCR4(3), FOS(2), GNAQ(4), JUN(1), MAPK14(5), MAPK8(1), PLCG1(9), PRKCA(10), PTK2B(10), SYT1(19)	4632368	76	48	71	54	50	6	4	11	5	0	0.834	1.000	1.000
486	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(3), GRB2(2), HRAS(3), MAPK1(4), MAPK3(1), MAPK7(4), MEF2A(5), MEF2B(2), MEF2C(2), MEF2D(4), NTRK1(15), PIK3CA(8), PIK3R1(3), PLCG1(9), RPS6KA1(6), SHC1(1)	6318731	72	48	68	53	45	10	2	7	7	1	0.966	1.000	1.000
487	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(19), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), SHMT1(1)	5049345	69	48	68	39	38	3	6	13	9	0	0.546	1.000	1.000
488	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(6), B3GAT2(2), B3GAT3(4), CHPF(3), CHST11(5), CHST12(4), CHST13(3), CHST14(3), CHST3(1), CHSY1(8), DSE(18), XYLT1(10), XYLT2(3)	4439467	70	48	70	46	47	9	3	7	4	0	0.461	1.000	1.000
489	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(7), ACOX3(11), FADS2(3), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9)	3390359	78	48	78	42	56	5	1	5	11	0	0.241	1.000	1.000
490	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(6), DHRS1(3), DHRS2(6), DHRS3(4), DHRS7(1), DHRSX(4), HEMK1(4), LCMT1(4), METTL2B(7), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), WBSCR22(1)	5049976	66	48	65	33	38	9	2	13	4	0	0.366	1.000	1.000
491	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(1), ACOT11(6), DHRS1(3), DHRS2(6), DHRS3(4), DHRS7(1), DHRSX(4), ECHS1(2), EHHADH(6), ESCO1(1), ESCO2(2), GCDH(5), HADHA(8), MYST3(15), MYST4(14), NAT6(2), PNPLA3(2), SH3GLB1(2), YOD1(1)	8743384	85	48	83	57	50	10	3	17	5	0	0.976	1.000	1.000
492	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(7), IL22(1), IL22RA1(11), IL22RA2(1), JAK1(6), JAK2(9), JAK3(6), SOCS3(2), STAT1(4), STAT3(10), STAT5A(2), STAT5B(4), TYK2(7)	6090468	70	48	70	43	36	6	7	14	7	0	0.823	1.000	1.000
493	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(19), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), SHMT1(1)	5049345	69	48	68	39	38	3	6	13	9	0	0.546	1.000	1.000
494	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(5), CHUK(2), IFNG(2), IKBKB(3), IL2(4), IL4(1), JUN(1), MAP3K1(2), MAP3K5(16), MAP4K5(3), MAPK14(5), MAPK8(1), NFKB1(7), NFKBIA(2), RELA(4), TNFRSF9(4), TNFSF9(1), TRAF2(2)	6407070	65	47	62	33	38	5	1	12	9	0	0.658	1.000	1.000
495	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(4), ACADM(5), ACADS(4), ACADVL(1), ACSL1(4), ACSL3(6), ACSL4(2), CPT1A(10), CPT2(1), DCI(2), EHHADH(6), HADHA(8), PECR(1), SCP2(2), SLC25A20(1)	5687170	57	47	54	30	38	3	3	7	6	0	0.711	1.000	1.000
496	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(3), JAK1(6), JAK2(9), JAK3(6), PIAS1(5), PIAS3(5), PTPRU(15), REG1A(7), SOAT1(3)	4569654	59	47	59	28	37	4	2	8	8	0	0.335	1.000	1.000
497	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), GCK(17), GFPT1(4), GNE(3), HEXA(5), HEXB(4), HK1(3), HK2(12), HK3(13), PGM3(1), RENBP(3), UAP1(2)	5683967	68	46	65	38	46	5	2	8	7	0	0.517	1.000	1.000
498	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(5), CD3D(5), CD3E(2), CD3G(1), GZMB(3), HLA-A(6), ICAM1(2), ITGAL(24), ITGB2(13), PRF1(11)	2909979	72	46	70	31	43	7	3	5	14	0	0.0621	1.000	1.000
499	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(35), CYP2C9(35)	675777	70	46	62	47	59	3	2	1	5	0	0.675	1.000	1.000
500	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(7), F13B(23), HSD17B2(9), HSD17B3(5), HSD17B4(6), HSD17B7(1), HSD3B1(10), HSD3B2(10)	2678975	71	46	66	32	50	4	5	4	7	1	0.109	1.000	1.000
501	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(4), ARFGAP3(3), ARFGEF2(15), CLTA(1), CLTB(1), COPA(6), GBF1(12), GPLD1(20), KDELR3(1)	5491871	63	45	63	38	35	5	4	13	6	0	0.817	1.000	1.000
502	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CALM2(1), CAMK1(4), CAMK1G(9), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CAMK4(10), CAMKK1(3), CAMKK2(7), SYT1(19)	3889849	72	45	67	57	53	7	2	6	4	0	0.906	1.000	1.000
503	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GALNS(4), GLB1(8), GNS(2), GUSB(3), HEXA(5), HEXB(4), IDS(9), IDUA(4), LCT(40), NAGLU(4)	4783621	84	45	82	46	66	5	0	8	5	0	0.406	1.000	1.000
504	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(1), MRPS7(1), RPL10L(6), RPL11(2), RPL13A(2), RPL14(1), RPL18(3), RPL18A(1), RPL19(1), RPL21(1), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL36AL(1), RPL38(1), RPL39(1), RPL3L(3), RPL6(1), RPL7(2), RPS10(1), RPS11(1), RPS13(1), RPS16(1), RPS18(1), RPS2(2), RPS20(2), RPS23(1), RPS24(1), RPS27(1), RPS29(1), RPS3A(1), RPS5(1), RPS6(1), RPS7(4), RPS8(1), RPSA(1)	7542160	61	45	61	41	33	5	7	10	6	0	0.856	1.000	1.000
505	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(4), APAF1(6), BCL2(2), CASP3(2), CASP9(3), CYCS(1), DAXX(9), FAS(5), FASLG(14), HSPB1(2), HSPB2(1), IL1A(4), MAPKAPK2(7), MAPKAPK3(3), TNF(1)	3812619	64	45	63	29	39	4	3	8	10	0	0.264	1.000	1.000
506	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(27), MAP2(13), PPP1CA(1), PPP2CA(1), PRKACB(4), PRKACG(8), PRKAG1(2), PRKAR2A(1), PRKAR2B(5), PRKCE(6)	6055010	68	44	67	42	40	7	4	8	9	0	0.952	1.000	1.000
507	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), KHK(1), LCT(40), MPI(1), PGM1(4), PYGL(7), PYGM(10), TREH(3)	4416819	69	44	68	56	54	6	1	5	3	0	0.789	1.000	1.000
508	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(10), CD4(6), HLA-DRA(11), HLA-DRB1(3), IL1B(6), IL4(1), IL5(4), IL5RA(12), IL6(2)	1787952	56	44	53	33	43	1	1	5	6	0	0.221	1.000	1.000
509	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(2), MAP3K14(3), MAPK14(5), MAPK8(1), NFKB1(7), RELA(4), TNFRSF13B(8), TNFRSF17(6), TNFSF13B(1), TRAF2(2), TRAF3(5), TRAF5(7), TRAF6(4)	4808832	55	44	54	26	35	6	0	11	3	0	0.447	1.000	1.000
510	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(18), EGFR(22), ERBB3(5), NRG1(14), UBE2D1(1)	3462760	60	43	60	40	45	1	3	7	4	0	0.965	1.000	1.000
511	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(8), IL13(2), IL4(1), IL5(4), MAF(1), MAP2K3(7), MAPK14(5), NFATC1(15), NFATC2(9), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5)	4032673	74	43	72	47	51	8	3	5	7	0	0.601	1.000	1.000
512	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	14	A4GALT(5), B3GALNT1(6), B3GALT5(1), FUT1(3), FUT2(3), FUT9(22), GBGT1(2), GLA(1), HEXA(5), HEXB(4), NAGA(3), ST3GAL1(6), ST3GAL2(1), ST8SIA1(1)	3595059	63	43	61	36	42	6	3	8	4	0	0.395	1.000	1.000
513	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(14), AMT(1), ATIC(5), FTCD(2), GART(9), MTFMT(2), MTHFD1(10), MTHFD1L(1), MTHFD2(2), MTHFR(1), MTR(9), SHMT1(1), SHMT2(2), TYMS(1)	6348907	60	43	59	37	39	5	3	6	7	0	0.751	1.000	1.000
514	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(6), CLOCK(4), CRY1(7), CRY2(3), CSNK1D(1), CSNK1E(4), NPAS2(4), PER1(8), PER2(11), PER3(9)	5694130	57	43	54	41	37	6	1	4	9	0	0.962	1.000	1.000
515	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2), ECHS1(2), EHHADH(6), HADHA(8), SDS(2)	4058870	56	43	54	31	31	9	2	9	5	0	0.425	1.000	1.000
516	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(2), CREBBP(20), EP300(14), HDAC3(5), IKBKB(3), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF6(4)	7465499	69	43	69	35	40	7	5	12	5	0	0.661	1.000	1.000
517	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(3), DPM2(1), GRB2(2), HRAS(3), KLK2(2), NTRK1(15), PIK3CA(8), PIK3R1(3), PLCG1(9), PRKCA(10), SHC1(1), SOS1(8)	5202210	65	43	63	33	40	8	2	9	5	1	0.645	1.000	1.000
518	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(12), CDC25A(8), CDC25B(4), CDC25C(4), CHEK1(2), MYT1(21), WEE1(2)	4612621	53	42	51	26	34	5	1	6	7	0	0.662	1.000	1.000
519	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(6), CHPT1(1), HEMK1(4), LCMT1(4), METTL2B(7), METTL6(2), PCYT1A(3), PCYT1B(7), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), WBSCR22(1)	4704823	59	42	58	24	34	7	4	10	4	0	0.149	1.000	1.000
520	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(2), B3GNT2(2), B3GNT7(4), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), CHST1(9), CHST2(4), CHST4(9), CHST6(4), FUT8(8), ST3GAL1(6), ST3GAL2(1), ST3GAL3(1), ST3GAL4(1)	4165088	60	42	59	38	39	12	4	2	3	0	0.448	1.000	1.000
521	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNB1(6), JAK1(6), PTPRU(15), REG1A(7), STAT1(4), STAT2(8), TYK2(7)	4197615	55	42	55	28	29	4	2	10	10	0	0.397	1.000	1.000
522	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(18), AOC2(7), AOC3(8), CES1(16), ESD(2)	2014132	51	41	49	34	41	2	4	2	2	0	0.622	1.000	1.000
523	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), CYP51A1(1), DHCR24(1), DHCR7(9), FDPS(3), GGCX(3), GGPS1(1), HMGCR(12), HSD17B7(1), IDI1(1), IDI2(1), LSS(2), MVD(1), MVK(2), NQO1(1), NSDHL(3), PMVK(2), SC4MOL(3), SC5DL(2), SQLE(4), TM7SF2(4)	6454179	58	41	56	31	26	11	4	10	7	0	0.533	1.000	1.000
524	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(6), ARHGAP5(11), ARHGDIB(3), CASP1(4), CASP10(4), CASP3(2), CASP8(8), CASP9(3), CYCS(1), GZMB(3), JUN(1), PRF1(11)	4333637	57	40	56	28	36	6	3	9	3	0	0.642	1.000	1.000
525	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(2), EGF(18), EGFR(22), HGS(3), RAB5A(1), TF(11), TFRC(4)	4297461	61	40	61	41	43	2	4	8	4	0	0.946	1.000	1.000
526	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(4), CAMK1G(9), HDAC9(38), MEF2A(5), MEF2B(2), MEF2C(2), MEF2D(4), MYOD1(1)	2478754	65	40	57	32	52	5	0	3	5	0	0.326	1.000	1.000
527	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(14), AMT(1), ATIC(5), GART(9), MTHFD1(10), MTHFD1L(1), MTHFD2(2), MTHFR(1), MTR(9), SHMT1(1), SHMT2(2), TYMS(1)	5995111	56	40	55	32	36	5	3	6	6	0	0.597	1.000	1.000
528	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(6), IFNG(2), IL10(3), IL12A(3), IL12B(3), IL13(2), IL15(3), IL16(12), IL18(2), IL1A(4), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL8(1), IL9(1), LTA(2), TNF(1)	3306170	60	39	59	34	41	3	3	4	9	0	0.229	1.000	1.000
529	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(7), CDKN1A(4), EPO(5), EPOR(1), GRIN1(7), HIF1A(5), JAK2(9), NFKB1(7), NFKBIA(2), RELA(4)	4194201	51	39	51	23	21	5	5	10	10	0	0.575	1.000	1.000
530	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	13	A4GALT(5), FUT1(3), FUT2(3), FUT9(22), GBGT1(2), GLA(1), HEXA(5), HEXB(4), NAGA(3), ST3GAL1(6), ST3GAL2(1), ST3GAL4(1), ST8SIA1(1)	3384736	57	39	55	28	38	6	1	8	4	0	0.180	1.000	1.000
531	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(7), ANKRD1(1), CYR61(1), DUSP14(2), EIF4EBP1(1), HBEGF(1), IFNG(2), IFRD1(2), IL18(2), IL1A(4), IL1R1(11), JUND(1), MYOG(3), NR4A3(7), WDR1(4)	3557358	49	39	47	23	31	5	2	4	7	0	0.451	1.000	1.000
532	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(20), EP300(14), ESR1(5), MAPK1(4), MAPK3(1), PELP1(11), SRC(1)	4908328	56	39	56	29	36	3	4	9	4	0	0.676	1.000	1.000
533	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(5), CBS(6), CTH(1), GGT1(6), MARS(6), MARS2(4), MAT1A(5), MAT2B(2), PAPSS1(3), PAPSS2(5), SCLY(3), SEPHS1(4)	4180628	50	39	50	21	31	4	3	7	5	0	0.118	1.000	1.000
534	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(10), CYP2E1(13), NR1I3(7), PTGS1(17), PTGS2(10)	1806954	57	38	55	31	42	4	1	4	6	0	0.203	1.000	1.000
535	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(3), GNAS(19), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10)	3165103	54	38	52	39	42	4	2	2	4	0	0.944	1.000	1.000
536	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(5), ACO2(4), AFMID(2), CS(2), GRHPR(2), HAO1(7), HAO2(11), HYI(1), MDH1(1), MDH2(4), MTHFD1(10), MTHFD1L(1), MTHFD2(2)	4489553	52	38	49	27	30	4	4	6	8	0	0.355	1.000	1.000
537	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), BLVRB(1), HMOX1(1), IL10(3), IL10RA(7), IL10RB(5), IL1A(4), IL6(2), JAK1(6), STAT1(4), STAT3(10), STAT5A(2), TNF(1)	4089982	48	38	47	26	22	5	6	7	8	0	0.479	1.000	1.000
538	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(2), IL2RG(3), IL4(1), IL4R(13), IRS1(5), JAK1(6), JAK3(6), RPS6KB1(2), SHC1(1), STAT6(7)	4937568	49	38	49	26	28	6	3	5	7	0	0.503	1.000	1.000
539	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(3), CREBBP(20), DFFA(2), DFFB(3), GZMA(11), GZMB(3), HMGB2(1), PRF1(11), SET(3)	3553310	57	38	55	19	33	4	5	10	5	0	0.115	1.000	1.000
540	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(2), IKBKAP(5), IKBKB(3), LTA(2), MAP3K1(2), MAP3K14(3), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), TNFAIP3(2), TNFRSF1B(3), TRAF1(6), TRAF2(2), TRAF3(5)	7459302	49	38	49	47	31	6	1	6	5	0	0.999	1.000	1.000
541	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(6), CHAT(14), CHKA(2), PCYT1A(3), PDHA1(3), PDHA2(17), PEMT(2), SLC18A3(2)	2296468	49	37	46	23	39	5	0	2	3	0	0.0943	1.000	1.000
542	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(2), JUN(1), MAPK3(1), OPRK1(21), POLR2A(11), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5)	4294432	58	37	58	54	45	3	3	3	4	0	0.987	1.000	1.000
543	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(8), DHRS1(3), DHRS2(6), DHRS3(4), DHRS7(1), DHRSX(4), HSD3B7(3), PON1(14), PON2(1), PON3(5), RDH11(2), RDH12(2), RDH13(3)	3030336	56	37	54	29	39	4	1	7	5	0	0.249	1.000	1.000
544	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(2), FOSL2(5), IFNAR1(2), IFNAR2(7), IFNB1(6), MAPK8(1), NFKB1(7), RELA(4), TNFRSF11A(5), TNFSF11(4), TRAF6(4)	3708288	47	37	46	24	30	3	0	9	5	0	0.635	1.000	1.000
545	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(14), MBTPS1(9), MBTPS2(1), SCAP(8), SREBF1(5), SREBF2(8)	3968538	47	37	45	25	30	2	3	8	4	0	0.468	1.000	1.000
546	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(1), DHCR7(9), FDPS(3), HMGCR(12), HMGCS1(2), IDI1(1), LSS(2), MVD(1), MVK(2), NSDHL(3), PMVK(2), SC4MOL(3), SC5DL(2), SQLE(4)	4409973	47	36	45	22	21	8	2	10	6	0	0.493	1.000	1.000
547	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(5), ACO2(4), CS(2), GRHPR(2), HAO1(7), HAO2(11), HYI(1), MDH1(1), MDH2(4), MTHFD1(10), MTHFD1L(1), MTHFD2(2)	4286373	50	36	47	23	29	4	3	6	8	0	0.221	1.000	1.000
548	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(10), CDO1(5), CSAD(4), GAD1(13), GAD2(7), GGT1(6)	1895413	45	36	44	25	30	4	4	5	2	0	0.448	1.000	1.000
549	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(17), HK1(3), HK2(12), HK3(13), IMPA1(1), IMPA2(2), ISYNA1(1), PGM1(4), PGM3(1), TGDS(1)	3900255	55	36	53	35	40	5	1	4	5	0	0.539	1.000	1.000
550	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), BET1L(1), BNIP1(1), GOSR1(1), SEC22B(5), SNAP25(6), SNAP29(1), STX10(1), STX11(1), STX12(1), STX16(2), STX17(1), STX19(2), STX2(4), STX3(2), STX5(4), STX6(1), TSNARE1(4), VAMP1(1), VAMP3(1), VAMP4(1), VAMP7(5), VAMP8(1), VTI1A(1), VTI1B(1)	5540826	50	36	47	26	28	5	1	9	7	0	0.492	1.000	1.000
551	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(3), IFNG(2), IFNGR1(4), JAK1(6), JAK2(9), PLA2G2A(2), PTPRU(15), REG1A(7), STAT1(4)	3823924	52	36	52	22	30	2	1	9	10	0	0.339	1.000	1.000
552	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(2), IKBKAP(5), IKBKB(3), MAP3K1(2), MAP3K14(3), NFKB1(7), NFKBIA(2), RELA(4), TNFAIP3(2), TRAF3(5), TRAF6(4)	6040771	39	35	39	33	23	6	1	6	3	0	0.990	1.000	1.000
553	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(4), HS3ST1(10), HS3ST2(7), HS3ST3A1(4), HS3ST3B1(2), XYLT1(10), XYLT2(3)	2125078	40	35	40	37	25	5	1	5	4	0	0.907	1.000	1.000
554	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(4), HS3ST1(10), HS3ST2(7), HS3ST3A1(4), HS3ST3B1(2), XYLT1(10), XYLT2(3)	2125078	40	35	40	37	25	5	1	5	4	0	0.907	1.000	1.000
555	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(5), CHST12(4), CHST13(3), PAPSS1(3), PAPSS2(5), SULT1A1(12), SULT1A2(2), SULT1E1(12), SULT2A1(7), SULT2B1(6), SUOX(4)	3049991	63	35	61	35	51	3	0	4	5	0	0.338	1.000	1.000
556	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(8), POLR2A(11), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(2)	4477860	42	35	41	16	25	4	2	6	5	0	0.142	1.000	1.000
557	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(17), CKM(2), FBL(1), GPT(3), LDHA(5), LDHB(2), LDHC(5), MAPK14(5), NCL(6)	3010319	46	35	45	22	32	2	4	5	3	0	0.358	1.000	1.000
558	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(3), IL13RA2(3), IL4R(13), JAK1(6), JAK2(9), TYK2(7)	3501773	43	35	43	21	26	2	2	8	5	0	0.605	1.000	1.000
559	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(3), IL13RA2(3), IL4R(13), JAK1(6), JAK2(9), TYK2(7)	3501773	43	35	43	21	26	2	2	8	5	0	0.605	1.000	1.000
560	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(2), CD36(4), FOS(2), FYN(6), JUN(1), MAPK14(5), THBS1(27)	2480709	47	35	47	27	28	1	2	7	9	0	0.775	1.000	1.000
561	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(3), DHRS2(6), DHRS3(4), DHRS7(1), DHRSX(4), ESCO1(1), ESCO2(2), MYST3(15), MYST4(14), NAT6(2), PNPLA3(2), SH3GLB1(2)	5581995	56	34	55	41	32	7	1	12	4	0	0.992	1.000	1.000
562	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(17), HK1(3), HK2(12), HK3(13), IMPA1(1), PGM1(4), PGM3(1), TGDS(1)	3428477	52	34	50	30	39	5	1	3	4	0	0.400	1.000	1.000
563	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(26), GNAS(19), PRKACA(3), PRKAR1A(1)	2172718	49	33	47	26	32	5	3	4	5	0	0.394	1.000	1.000
564	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(19), GNA12(3), PRKACB(4), PRKACG(8), PRKAG1(2), PRKAR2A(1), PRKAR2B(5)	3379191	42	31	42	26	30	3	1	5	3	0	0.771	1.000	1.000
565	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(2), IFNAR2(7), IFNB1(6), JAK1(6), STAT1(4), STAT2(8), TYK2(7)	3610515	41	31	41	19	21	3	2	9	6	0	0.450	1.000	1.000
566	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(9), CAPN1(4), CAPNS1(1), CDK5(4), CSNK1A1(2), CSNK1D(1), GSK3B(2), MAPT(10), PPP2CA(1)	3012036	34	31	34	16	22	2	2	3	5	0	0.349	1.000	1.000
567	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(9), FDPS(3), HMGCR(12), IDI1(1), LSS(2), MVD(1), MVK(2), NQO1(1), PMVK(2), SC5DL(2), SQLE(4)	3690312	39	30	37	20	16	6	2	10	5	0	0.625	1.000	1.000
568	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	11	ACLY(9), ACO1(5), ACO2(4), ACSS1(1), ACSS2(4), FH(3), IDH1(12), IDH2(2), MDH1(1), MDH2(4)	4483107	45	30	35	23	31	0	2	8	4	0	0.343	1.000	1.000
569	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(5), PSMA2(1), PSMA4(1), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC2(2), PSMC3(4), PSMD1(5), PSMD12(1), PSMD13(3), PSMD2(3)	5410945	39	30	38	19	22	4	2	8	3	0	0.685	1.000	1.000
570	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3D(5), CD3E(2), CD3G(1), IFNG(2), IL2(4), IL2RA(4), IL4(1), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(8), TGFBR3(6), TOB1(2), TOB2(2)	3525657	43	30	43	25	34	2	0	1	6	0	0.523	1.000	1.000
571	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(4), NRF1(4), UBE2D1(1), UBE2D3(3), UBE2E1(1), UBE2E3(1), UBE2G2(1), UBE2H(1), UBE2I(2), UBE2J1(2), UBE2J2(6), UBE2L6(2), UBE2M(1), UBE2S(2), UBE3A(6)	3546056	37	30	36	17	24	5	1	5	2	0	0.538	1.000	1.000
572	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2)	2661393	38	29	37	24	20	7	2	5	4	0	0.593	1.000	1.000
573	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2)	2661393	38	29	37	24	20	7	2	5	4	0	0.593	1.000	1.000
574	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(6), ADORA2A(2), ADORA2B(1), ADORA3(12), LTB4R(1), P2RY1(4), P2RY2(8), P2RY6(1)	1995771	35	29	35	28	22	5	0	5	3	0	0.329	1.000	1.000
575	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(6), JAK2(9), JAK3(6), MAPK1(4), MAPK3(1), STAT3(10), TYK2(7)	3894052	43	29	43	31	20	5	3	8	7	0	0.929	1.000	1.000
576	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(17), EIF2AK4(13), EIF2B5(1), EIF2S1(1), EIF5(1), GSK3B(2), PPP1CA(1)	3901306	36	28	32	15	16	1	1	12	6	0	0.760	1.000	1.000
577	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(12), ENO1(4), GPI(3), HK1(3), PFKL(4), PGK1(4), PKLR(11)	3073161	41	28	38	17	28	4	1	4	4	0	0.0350	1.000	1.000
578	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), MIOX(3), UGDH(1)	2834324	36	28	34	26	19	7	4	3	3	0	0.784	1.000	1.000
579	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(2), CTSD(3), ESR1(5), GREB1(18), HSPB1(2), HSPB2(1), MTA1(2), MTA3(2), PDZK1(3), TUBA8(3)	3569272	41	28	40	26	30	2	3	4	2	0	0.549	1.000	1.000
580	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(8), CDC25B(4), CDC25C(4), CSK(1), GRB2(2), PRKCA(10), PTPRA(7), SRC(1)	3114858	37	28	36	23	24	6	1	4	2	0	0.705	1.000	1.000
581	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(6), CD80(4), HLA-DRA(11), HLA-DRB1(3), IL10(3), IL2(4), IL4(1)	1320155	33	26	33	20	21	1	1	6	4	0	0.435	1.000	1.000
582	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(6), CLOCK(4), CRY1(7), CRY2(3), CSNK1E(4), PER1(8)	2828041	32	26	31	15	19	3	1	3	6	0	0.616	1.000	1.000
583	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(5), ACAA2(1), ACAT2(1), ECHS1(2), EHHADH(6), HADHA(8), HADHB(4), SDS(2)	2803354	29	26	28	14	18	3	1	4	3	0	0.538	1.000	1.000
584	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(6), B3GALT1(11), B3GALT2(1), B3GALT5(1), B3GNT5(1), FUT1(3), FUT2(3), FUT3(4), ST3GAL3(1), ST3GAL4(1)	2400983	32	26	32	25	23	3	0	3	3	0	0.824	1.000	1.000
585	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(8), PLCG1(9), PRKCA(10), PTK2B(10)	2265197	37	26	36	26	28	3	1	2	3	0	0.564	1.000	1.000
586	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(6), ADSS(2), IMPDH1(2), MTHFD2(2), POLD1(6), POLG(8), PRPS2(3), RRM1(3)	4159305	32	26	32	25	17	3	1	5	6	0	0.957	1.000	1.000
587	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(5), PSMA2(1), PSMA4(1), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC3(4), PSMD14(1), RPN2(2), UBE3A(6)	4355454	34	26	34	17	18	4	1	8	3	0	0.715	1.000	1.000
588	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(3), BIRC3(7), CASP8(8), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF2(2)	2744700	28	26	28	12	19	1	2	3	3	0	0.340	1.000	1.000
589	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	FOS(2), JUN(1), KEAP1(2), MAFG(1), MAPK1(4), MAPK14(5), MAPK8(1), NFE2L2(4), PRKCA(10)	2962889	30	25	29	14	19	2	0	4	5	0	0.469	1.000	1.000
590	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(3), GBA(3), GBA3(14), GGT1(6), SHMT1(1), SHMT2(2)	1794474	29	25	27	16	22	1	0	3	3	0	0.332	1.000	1.000
591	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(22), RANGAP1(3)	2856977	26	24	26	11	17	2	1	3	3	0	0.651	1.000	1.000
592	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(2), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT5(2), FUT8(8), ST3GAL1(6), ST3GAL2(1), ST3GAL3(1), ST3GAL4(1)	2630152	27	23	27	17	14	6	3	2	2	0	0.722	1.000	1.000
593	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(2), CDC25A(8), CDC25B(4), CDC25C(4), MNAT1(2), SHH(4), XPO1(2)	2926615	26	23	26	11	15	3	2	5	1	0	0.522	1.000	1.000
594	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	11	ALAD(5), ALAS1(1), ALAS2(5), CPO(2), FECH(3), GATA1(2), HBB(6), HMBS(1), UROS(1)	2557315	26	22	25	18	20	2	0	1	3	0	0.701	1.000	1.000
595	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(6), FUT1(3), FUT2(3), FUT3(4), FUT5(6), FUT6(4), ST3GAL3(1)	1671750	27	22	27	18	15	3	1	2	6	0	0.478	1.000	1.000
596	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(14), GGT1(6), SHMT1(1), SHMT2(2)	1359033	23	22	21	15	17	1	0	3	2	0	0.473	1.000	1.000
597	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1), BDH1(5), HMGCL(4), HMGCS1(2), HMGCS2(17), OXCT1(4), OXCT2(3)	2393850	36	22	35	20	24	5	0	5	2	0	0.677	1.000	1.000
598	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(2), HBXIP(1), HRAS(3), PTK2B(10), SHC1(1), SOS1(8), SRC(1)	2947939	26	21	26	22	18	2	0	4	2	0	0.983	1.000	1.000
599	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(4), CS(2), FH(3), IDH2(2), MDH1(1), OGDH(11), SDHA(1)	3176777	24	20	23	17	15	0	2	3	4	0	0.860	1.000	1.000
600	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(1), CSF1(10), IL6(2), LDLR(14), LPL(3)	1796343	30	20	30	15	21	3	2	3	1	0	0.321	1.000	1.000
601	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), CSF1(10), IL1B(6), MST1(1), MST1R(7), TNF(1)	2192503	26	20	25	21	20	2	1	0	3	0	0.845	1.000	1.000
602	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(6), HLA-DRA(11), HLA-DRB1(3)	788509	21	19	21	14	16	1	0	3	1	0	0.536	1.000	1.000
603	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(8), EPHX2(4), HSD3B7(3), RDH11(2), RDH12(2), RDH13(3)	1616002	22	19	22	17	15	1	2	1	3	0	0.763	1.000	1.000
604	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(21), PNPO(1), PSAT1(2)	1631742	24	19	23	18	20	1	1	2	0	0	0.856	1.000	1.000
605	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(5), APOBEC1(3), APOBEC2(3), APOBEC3A(2), APOBEC3B(2), APOBEC3C(2), APOBEC3F(4), APOBEC3G(2)	2478826	23	19	23	26	17	2	3	1	0	0	0.993	1.000	1.000
606	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(4), IFNGR2(4), JAK1(6), JAK2(9), STAT1(4)	2736082	29	19	27	10	11	1	1	7	9	0	0.687	1.000	1.000
607	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(6), ST3GAL2(1), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(2), ST6GALNAC4(1), ST8SIA1(1)	1902275	16	16	16	11	11	2	1	2	0	0	0.650	1.000	1.000
608	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(7), CD28(1), CD3D(5), CD3E(2), CD3G(1), CD4(6)	1074220	22	16	22	22	15	3	0	3	1	0	0.918	1.000	1.000
609	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ3(2), COQ5(2), COQ6(1), COQ7(2), NDUFA12(1), NDUFA13(6)	1333886	15	15	14	11	12	1	2	0	0	0	0.873	1.000	1.000
610	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(5), BMPR1A(2), BMPR1B(3), BMPR2(5)	2106226	15	15	15	10	7	3	0	3	2	0	0.837	1.000	1.000
611	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(4), HGD(12)	754252	16	14	16	16	12	2	2	0	0	0	0.938	1.000	1.000
612	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(1), DLL1(2), FURIN(5), NOTCH1(6), PSEN1(1)	3078315	15	14	15	17	8	3	1	3	0	0	0.972	1.000	1.000
613	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(17)	612499	19	12	18	11	14	2	1	2	0	0	0.580	1.000	1.000
614	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(6), ARG1(1), GLS(2), GLUD1(2), OAT(3), PRODH(1)	1823373	15	11	15	13	5	5	2	2	1	0	0.950	1.000	1.000
615	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(2), TGDS(1), UGDH(1), UGP2(1), UXS1(4)	1652848	9	9	9	10	4	0	1	0	4	0	0.987	1.000	1.000
616	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(4)	712936	4	4	4	5	3	0	0	1	0	0	0.943	1.000	1.000
