rank	geneset	description	genes	N_genes	mut_tally	N	n	npat	nsite	nsil	n1	n2	n3	n4	n5	n6	p_ns_s	p	q
1	HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM	Genes involved in D-arginine and D-ornithine metabolism	DAO	1	DAO(10)	240807	10	10	10	2	7	1	1	1	0	0	0.124	0.109	1.000
2	HSA00627_1,4_DICHLOROBENZENE_DEGRADATION	Genes involved in 1,4-dichlorobenzene degradation	CMBL	1	CMBL(4)	172740	4	4	4	1	4	0	0	0	0	0	0.482	0.466	1.000
3	FOSBPATHWAY	FOSB gene expression and drug abuse	CDK5, FOSB, GRIA2, JUND, PPP1R1B	5	CDK5(4), FOSB(5), GRIA2(34), JUND(1), PPP1R1B(2)	1226014	46	39	43	15	28	3	2	6	7	0	0.0690	0.828	1.000
4	HSA00401_NOVOBIOCIN_BIOSYNTHESIS	Genes involved in novobiocin biosynthesis	GOT1, GOT2, TAT	3	GOT1(6), GOT2(5), TAT(17)	883649	28	18	27	7	21	2	2	1	2	0	0.0148	0.883	1.000
5	SLRPPATHWAY	Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix.	BGN, DCN, DSPG3, FMOD, KERA, LUM	5	BGN(6), DCN(17), FMOD(4), KERA(14), LUM(11)	1178331	52	38	48	16	41	4	3	1	3	0	0.00183	0.888	1.000
6	PEPIPATHWAY	Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils.	ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI	3	GRN(4), IL8(1), SLPI(6)	576974	11	11	11	4	5	1	0	4	1	0	0.437	0.919	1.000
7	BOTULINPATHWAY	Blockade of Neurotransmitter Relase by Botulinum Toxin	CHRM1, CHRNA1, SNAP25, STX1A, VAMP2	5	CHRM1(5), CHRNA1(5), SNAP25(6), STX1A(2)	1097766	18	15	15	3	12	1	0	1	4	0	0.0101	0.946	1.000
8	HSA00785_LIPOIC_ACID_METABOLISM	Genes involved in lipoic acid metabolism	LIAS, LIPT1, LOC387787	2	LIAS(2), LIPT1(2)	519728	4	3	4	0	0	2	0	1	1	0	0.334	0.953	1.000
9	INOSITOL_METABOLISM		ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1	5	ALDH6A1(3), ALDOA(2), ALDOB(12), ALDOC(3)	1324868	20	15	17	4	15	2	0	1	2	0	0.0140	0.973	1.000
10	HSA00031_INOSITOL_METABOLISM	Genes involved in inositol metabolism	ALDH6A1, TPI1	2	ALDH6A1(3)	556442	3	3	2	1	2	0	0	1	0	0	0.552	0.984	1.000
11	HSA03060_PROTEIN_EXPORT	Genes involved in protein export	OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR	7	SEC61A2(7), SRP19(6), SRP54(3), SRP68(7), SRP72(1), SRP9(1), SRPR(2)	2220567	27	22	27	6	7	0	3	10	7	0	0.321	0.993	1.000
12	TCRMOLECULE	T Cell Receptor and CD3 Complex	CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@	3	CD3D(5), CD3E(2), CD3G(1)	377095	8	6	8	5	7	0	0	0	1	0	0.701	0.993	1.000
13	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.	CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1	12	CCNA1(13), CCND1(1), CCNE1(4), CCNE2(12), CDK4(5), CDKN1B(1), E2F1(5), E2F2(4), E2F4(1), PRB1(29)	2814031	75	54	67	16	51	0	4	17	3	0	0.00145	0.994	1.000
14	SA_G1_AND_S_PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.	ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53	13	CCND1(1), CDK4(5), CDKN1A(4), CDKN1B(1), CFL1(1), E2F1(5), E2F2(4), MDM2(3), NXT1(2), PRB1(29)	2351186	55	39	51	14	35	3	2	11	4	0	0.00929	0.999	1.000
15	SA_FAS_SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.	BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6	6	BCL2(2), CASP3(2), CASP8(8), CFL1(1), CFLAR(4), PDE6D(2)	1311615	19	17	19	7	8	1	2	6	2	0	0.523	1.000	1.000
16	NUCLEOTIDE_SUGARS_METABOLISM		GALE, GALT, TGDS, UGDH, UXS1	5	GALT(2), TGDS(1), UGDH(1), UXS1(4)	1296567	8	8	8	9	3	0	1	0	4	0	0.985	1.000	1.000
17	CAPROLACTAM_DEGRADATION		AKR1A1, ECHS1, EHHADH, HADHA, SDS	5	AKR1A1(3), ECHS1(2), EHHADH(6), HADHA(8), SDS(2)	1624136	21	19	19	8	13	2	0	5	1	0	0.244	1.000	1.000
18	TERCPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	NFYA, NFYB, NFYC, RB1, SP1, SP3	6	NFYA(1), NFYB(3), NFYC(1), RB1(8), SP1(5), SP3(1)	2236930	19	16	19	5	2	2	2	6	5	2	0.349	1.000	1.000
19	HSA00830_RETINOL_METABOLISM	Genes involved in retinol metabolism	ALDH1A1, ALDH1A2, BCMO1, RDH5	4	ALDH1A1(4), ALDH1A2(11), BCMO1(15), RDH5(2)	1310017	32	28	29	11	22	2	1	4	3	0	0.0561	1.000	1.000
20	IL18PATHWAY	Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation.	CASP1, IFNG, IL12A, IL12B, IL18, IL2	6	CASP1(4), IFNG(2), IL12A(3), IL12B(3), IL18(2), IL2(4)	986629	18	9	18	7	12	2	0	2	2	0	0.258	1.000	1.000
21	PKCPATHWAY	Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C.	GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA	6	GNAQ(4), NFKB1(7), NFKBIA(2), PLCB1(48), PRKCA(10), RELA(4)	2743472	75	54	70	25	58	3	2	7	5	0	0.0274	1.000	1.000
22	1_AND_2_METHYLNAPHTHALENE_DEGRADATION		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1	7	ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH6(11), ADH7(13), ADHFE1(5)	1891393	108	71	90	31	83	8	5	9	3	0	0.000740	1.000	1.000
23	TERPENOID_BIOSYNTHESIS		FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE	4	FDPS(3), IDI1(1), SQLE(4)	1066021	8	8	8	3	4	1	1	2	0	0	0.478	1.000	1.000
24	BETAOXIDATIONPATHWAY	Beta-Oxidation of Fatty Acids	ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA	6	ACADL(4), ACADM(5), ACADS(4), ECHS1(2), HADHA(8)	1842666	23	21	23	7	14	2	1	6	0	0	0.263	1.000	1.000
25	METHIONINEPATHWAY	Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	BCKDHB, BCKDK, CBS, CTH, MUT	5	BCKDHB(2), BCKDK(2), CBS(6), CTH(1), MUT(5)	1707246	16	16	16	6	10	2	1	2	1	0	0.356	1.000	1.000
26	ST_PAC1_RECEPTOR_PATHWAY	The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C.	ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP	6	CAMP(1), DAG1(5), GNAQ(4), ITPKB(7)	2011071	17	17	17	7	11	0	1	1	4	0	0.308	1.000	1.000
27	HSA00780_BIOTIN_METABOLISM	Genes involved in biotin metabolism	BTD, HLCS, SPCS1, SPCS3	4	BTD(3), HLCS(6)	1038760	9	9	9	9	6	0	1	1	1	0	0.913	1.000	1.000
28	NEUROTRANSMITTERSPATHWAY	Biosynthesis of neurotransmitters	DBH, GAD1, HDC, PNMT, TH, TPH1	6	DBH(13), GAD1(13), HDC(19), PNMT(4), TH(9), TPH1(5)	1997200	63	47	60	26	52	2	2	2	5	0	0.0110	1.000	1.000
29	VOBESITYPATHWAY	The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance.	APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF	7	HSD11B1(11), LPL(3), NR3C1(7), PPARG(11), RETN(3), RXRA(4), TNF(1)	1954008	40	32	38	14	27	2	0	6	5	0	0.0644	1.000	1.000
30	BENZOATE_DEGRADATION_VIA_COA_LIGATION		ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS	10	ACAT2(1), ECHS1(2), EHHADH(6), GCDH(5), HADHA(8), SDHB(1), SDS(2)	2619327	25	21	24	8	17	3	0	4	1	0	0.131	1.000	1.000
31	SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES		ACAT1, ACAT2, BDH, HMGCL, OXCT1	4	ACAT2(1), HMGCL(4), OXCT1(4)	1128896	9	9	9	5	6	1	0	1	1	0	0.721	1.000	1.000
32	HSA00730_THIAMINE_METABOLISM	Genes involved in thiamine metabolism	LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1	8	LHPP(1), MTMR1(4), MTMR2(2), MTMR6(2), NFS1(3), TPK1(8)	2144617	20	18	19	7	14	1	2	1	1	1	0.383	1.000	1.000
33	RECKPATHWAY	RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis.	HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4	9	HRAS(3), MMP14(2), MMP2(7), MMP9(7), RECK(11), TIMP1(1), TIMP2(1), TIMP3(5), TIMP4(6)	2489661	43	35	41	14	25	3	2	10	3	0	0.0792	1.000	1.000
34	EOSINOPHILSPATHWAY	Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor.	CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5	8	CCL11(1), CCR3(10), CSF2(2), HLA-DRA(11), HLA-DRB1(3), IL3(3), IL5(4)	1015009	34	26	33	16	28	1	0	3	2	0	0.0677	1.000	1.000
35	HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM	Genes involved in D-glutamine and D-glutamate metabolism	GLS, GLS2, GLUD1, GLUD2	4	GLS(2), GLS2(3), GLUD1(2), GLUD2(4)	1523529	11	9	11	7	3	3	1	1	3	0	0.801	1.000	1.000
36	HSA00950_ALKALOID_BIOSYNTHESIS_I	Genes involved in alkaloid biosynthesis I	DDC, GOT1, GOT2, TAT, TYR	5	DDC(12), GOT1(6), GOT2(5), TAT(17), TYR(8)	1576532	48	30	47	20	36	4	3	1	4	0	0.112	1.000	1.000
37	FBW7PATHWAY	Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E.	CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1	8	CCNE1(4), CDC34(4), CUL1(5), E2F1(5), FBXW7(11), RB1(8), TFDP1(2)	2727106	39	31	38	12	16	2	5	6	8	2	0.129	1.000	1.000
38	RABPATHWAY	Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins.	ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A	9	ACTA1(4), RAB11A(1), RAB1A(1), RAB27A(3), RAB3A(2), RAB5A(1)	1413500	12	10	12	6	9	1	1	1	0	0	0.515	1.000	1.000
39	VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS		BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB	7	BCAT1(11), IARS(8), LARS(10), LARS2(4), PDHA1(3), PDHA2(17), PDHB(1)	3377570	54	39	50	13	36	6	1	6	5	0	0.0190	1.000	1.000
40	HSA00300_LYSINE_BIOSYNTHESIS	Genes involved in lysine biosynthesis	AADAT, AASDHPPT, AASS, KARS	4	AADAT(5), AASDHPPT(3), AASS(3), KARS(4)	1559878	15	15	15	5	13	0	0	2	0	0	0.381	1.000	1.000
41	ERYTHPATHWAY	Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow.	CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3	15	CSF2(2), CSF3(4), EPO(5), FLT3(31), IGF1(11), IL11(2), IL1A(4), IL3(3), IL6(2), IL9(1), KITLG(8), TGFB1(1), TGFB2(1), TGFB3(3)	2757762	78	51	73	29	51	7	4	10	6	0	0.0154	1.000	1.000
42	RIBOFLAVIN_METABOLISM		ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR	10	ACP1(3), ACP2(2), ACP5(3), ACPP(8), ENPP1(11), ENPP3(14), FLAD1(9), TYR(8)	3236729	58	42	56	16	37	5	2	5	9	0	0.0201	1.000	1.000
43	PARKINPATHWAY	In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein.	GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1	10	GPR37(9), PARK2(8), SNCA(2), SNCAIP(47), UBE2E2(4), UBE2F(4), UBE2G2(1), UBE2L6(2)	2156876	77	56	70	26	58	9	1	4	5	0	0.0245	1.000	1.000
44	PROTEASOME		PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9	17	PSMA1(5), PSMA2(1), PSMA4(1), PSMA5(3), PSMA6(4), PSMB1(1), PSMB10(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMB8(5)	2958849	27	21	27	9	14	2	2	6	3	0	0.342	1.000	1.000
45	HEME_BIOSYNTHESIS		ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS	9	ALAD(5), ALAS1(1), ALAS2(5), CPOX(4), FECH(3), HMBS(1), PPOX(3), UROS(1)	2536645	23	20	23	9	15	2	1	2	3	0	0.256	1.000	1.000
46	SA_G2_AND_M_PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.	CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1	7	CDC25A(8), CDC25B(4), CDKN1A(4), CHEK1(2), NEK1(8), WEE1(2)	2324381	28	22	28	7	14	5	1	4	4	0	0.164	1.000	1.000
47	HSA00900_TERPENOID_BIOSYNTHESIS	Genes involved in terpenoid biosynthesis	FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE	6	FDPS(3), GGPS1(1), IDI1(1), IDI2(1), SQLE(4)	1425377	10	10	10	5	6	1	1	2	0	0	0.588	1.000	1.000
48	SALMONELLAPATHWAY	Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure.	ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL	11	ACTA1(4), ACTR2(3), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(2), WASF1(4), WASL(5)	2585798	26	22	26	8	16	2	1	3	4	0	0.208	1.000	1.000
49	PLCDPATHWAY	Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C.	ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2	4	ADRA1B(3), PLCD1(3), PRKCA(10), TGM2(8)	1666546	24	18	23	10	19	2	0	0	3	0	0.0483	1.000	1.000
50	HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA	Genes involved in fatty acid elongation in mitochondria	ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2	10	ACAA2(1), ECHS1(2), HADHA(8), HADHB(4), HSD17B10(2), HSD17B4(6), MECR(5), PPT1(4), PPT2(8)	2845585	40	38	38	14	17	4	4	12	3	0	0.277	1.000	1.000
51	FOLATE_BIOSYNTHESIS		ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR	9	ALPI(8), ALPL(9), ALPP(9), ALPPL2(11), FPGS(3), GGH(2), SPR(2)	2132193	44	31	41	18	35	5	2	1	1	0	0.0216	1.000	1.000
52	SA_PROGRAMMED_CELL_DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.	APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1	12	APAF1(6), BAX(3), BCL10(3), BCL2(2), BCL2L11(5), CASP8AP2(7), CASP9(3), CES1(16)	3615720	45	32	44	13	28	6	2	3	6	0	0.0919	1.000	1.000
53	SKP2E2FPATHWAY	E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E.	CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1	9	CCNA1(13), CCNE1(4), CDC34(4), CUL1(5), E2F1(5), RB1(8), SKP2(2), TFDP1(2)	2852159	43	35	43	15	24	2	4	6	5	2	0.115	1.000	1.000
54	CDK5PATHWAY	Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway.	CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1	12	CDK5(4), DPM2(1), EGR1(4), HRAS(3), KLK2(2), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), NGFR(7), RAF1(8)	2713240	47	41	41	22	24	4	2	10	7	0	0.262	1.000	1.000
55	DNAFRAGMENTPATHWAY	DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G.	CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B	9	CASP3(2), CASP7(4), DFFA(2), DFFB(3), GZMB(3), HMGB1(1), HMGB2(1), TOP2A(10), TOP2B(8)	2999482	34	26	34	10	22	1	4	5	2	0	0.232	1.000	1.000
56	HSA00930_CAPROLACTAM_DEGRADATION	Genes involved in caprolactam degradation	AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3	13	AKR1A1(3), ECHS1(2), EHHADH(6), HADHA(8), HSD17B10(2), HSD17B4(6), NTAN1(1), SIRT2(1), SIRT5(7), SIRT7(2), VNN2(14)	3970064	52	41	50	14	33	5	3	9	2	0	0.0269	1.000	1.000
57	MALATEXPATHWAY	The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm.	ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11	8	ACLY(9), CS(2), MDH1(1), ME1(19), PC(12), PDHA1(3), SLC25A11(2)	3123056	48	34	47	19	28	5	2	9	4	0	0.0811	1.000	1.000
58	ETCPATHWAY	Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water.	ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1	9	ATP5A1(1), CYCS(1), GPD2(2), SDHA(1), SDHB(1), SDHC(2), SDHD(1), UQCRC1(3)	2230829	12	12	12	5	8	0	1	1	2	0	0.477	1.000	1.000
59	TERTPATHWAY	hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers.	HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42	6	HDAC1(1), MYC(5), SP1(5), SP3(1), WT1(5)	2102838	17	15	17	7	9	2	3	2	1	0	0.549	1.000	1.000
60	LYSINE_BIOSYNTHESIS		AADAT, AASDH, AASDHPPT, AASS, KARS	5	AADAT(5), AASDH(5), AASDHPPT(3), AASS(3), KARS(4)	2313755	20	18	20	7	17	0	0	2	1	0	0.392	1.000	1.000
61	HSA00740_RIBOFLAVIN_METABOLISM	Genes involved in riboflavin metabolism	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR	16	ACP1(3), ACP2(2), ACP5(3), ACP6(11), ACPP(8), ENPP1(11), ENPP3(14), FLAD1(9), LHPP(1), MTMR1(4), MTMR2(2), MTMR6(2), TYR(8)	5021300	78	51	75	20	49	6	6	7	10	0	0.00523	1.000	1.000
62	CYSTEINE_METABOLISM		CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST	8	CARS(9), CTH(1), GOT1(6), GOT2(5), LDHA(5), LDHB(2), LDHC(5), MPST(2)	2303403	35	27	33	13	26	1	5	2	1	0	0.118	1.000	1.000
63	SULFUR_METABOLISM		BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX	7	PAPSS1(3), PAPSS2(5), SULT1A2(2), SULT1E1(12), SULT2A1(7), SUOX(4)	2044636	33	19	32	11	26	1	0	2	4	0	0.105	1.000	1.000
64	UBIQUINONE_BIOSYNTHESIS		NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2	15	NDUFA10(2), NDUFA4(1), NDUFB2(3), NDUFB5(3), NDUFB6(2), NDUFS2(2), NDUFV1(2)	2347626	15	15	15	6	10	0	1	3	1	0	0.551	1.000	1.000
65	PANTOTHENATE_AND_COA_BIOSYNTHESIS		BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1	12	BCAT1(11), COASY(3), DPYD(56), DPYS(22), ENPP1(11), ENPP3(14), PANK1(2), PANK2(3), PANK3(3), PANK4(6), PPCS(3), UPB1(6)	4653241	140	79	126	38	100	10	4	16	10	0	0.000218	1.000	1.000
66	FXRPATHWAY	The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis.	FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA	5	LDLR(14), NR0B2(6), NR1H3(3), RXRA(4)	1503298	27	18	27	14	19	3	1	2	2	0	0.183	1.000	1.000
67	HSA00272_CYSTEINE_METABOLISM	Genes involved in cysteine metabolism	CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1	17	CARS(9), CARS2(2), CDO1(5), CTH(1), GOT1(6), GOT2(5), LDHA(5), LDHAL6A(4), LDHAL6B(7), LDHB(2), LDHC(5), MPST(2), SDS(2), SULT1B1(11), SULT1C2(5), SULT1C4(12), SULT4A1(8)	4209458	91	60	87	29	63	3	9	7	9	0	0.00385	1.000	1.000
68	PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS		ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS	9	ENO1(4), ENO2(4), ENO3(4), FARS2(4), GOT1(6), GOT2(5), PAH(8), TAT(17), YARS(1)	2799697	53	39	50	21	40	5	2	3	3	0	0.0250	1.000	1.000
69	UREACYCLEPATHWAY	Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed.	ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1	6	ARG1(1), ASL(6), CPS1(21), GLS(2), GLUD1(2), GOT1(6)	2558390	38	27	36	15	24	3	2	7	2	0	0.248	1.000	1.000
70	P27PATHWAY	p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination.	CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M	12	CCNE1(4), CDKN1B(1), CUL1(5), E2F1(5), NEDD8(1), RB1(8), SKP2(2), TFDP1(2), UBE2M(1)	2879255	29	28	29	12	11	2	4	4	6	2	0.355	1.000	1.000
71	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.	AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1	15	AKT1(3), AKT2(8), AKT3(4), CDKN1A(4), ELK1(2), GRB2(2), HRAS(3), MAP2K1(10), MAP2K2(3), NGFR(7), NTRK1(15), PIK3CA(8), PIK3CD(7), SHC1(1), SOS1(8)	5331617	85	59	78	28	42	13	2	18	10	0	0.0492	1.000	1.000
72	STEMPATHWAY	In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection.	CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9	15	CD4(6), CD8A(2), CSF1(10), CSF2(2), CSF3(4), EPO(5), IL11(2), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(5), IL8(1), IL9(1)	2024094	52	35	51	28	37	4	1	4	6	0	0.125	1.000	1.000
73	HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS	Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis	FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2	9	FARS2(4), FARSA(6), FARSB(5), GOT1(6), GOT2(5), PAH(8), TAT(17), YARS(1), YARS2(2)	2921402	54	39	51	22	39	6	2	2	5	0	0.0514	1.000	1.000
74	MITOCHONDRIAPATHWAY	Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9.	APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8	18	APAF1(6), BAX(3), BCL2(2), BIK(2), BIRC2(5), BIRC3(7), CASP3(2), CASP7(4), CASP8(8), CASP9(3), CYCS(1), DFFA(2), DFFB(3), DIABLO(1)	4522355	49	38	49	15	26	5	6	7	5	0	0.149	1.000	1.000
75	HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS	Genes involved in pantothenate and CoA biosynthesis	BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1	16	BCAT1(11), BCAT2(1), COASY(3), DPYD(56), DPYS(22), ENPP1(11), ENPP3(14), ILVBL(4), PANK1(2), PANK2(3), PANK3(3), PANK4(6), PPCS(3), UPB1(6), VNN1(7)	5774266	152	81	138	43	110	10	4	17	11	0	6.21e-05	1.000	1.000
76	HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	Genes involved in neuroactive ligand-receptor interaction	ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2	236	ADCYAP1R1(16), ADORA1(6), ADORA2A(2), ADORA2B(1), ADORA3(12), ADRA1A(8), ADRA1B(3), ADRA2A(3), ADRA2B(9), ADRA2C(2), ADRB1(5), ADRB2(2), AGTR1(10), AGTR2(9), AVPR1A(4), AVPR1B(9), AVPR2(1), BDKRB1(5), BDKRB2(9), BRS3(5), C3AR1(4), C5AR1(9), CALCR(15), CALCRL(14), CCKAR(9), CCKBR(10), CGA(1), CHRM1(5), CHRM2(18), CHRM3(19), CHRM4(6), CHRM5(4), CNR1(9), CNR2(4), CRHR1(6), CRHR2(2), CTSG(4), CYSLTR1(4), CYSLTR2(2), DRD1(8), DRD2(15), DRD3(5), DRD4(1), DRD5(22), EDNRA(8), EDNRB(4), F2(9), F2R(6), F2RL1(15), F2RL2(6), F2RL3(3), FPR1(18), FSHB(4), FSHR(15), GABBR1(7), GABBR2(10), GABRA1(16), GABRA2(15), GABRA3(19), GABRA4(12), GABRA5(2), GABRA6(22), GABRB1(16), GABRB2(19), GABRB3(17), GABRD(5), GABRE(20), GABRG1(28), GABRG2(14), GABRG3(7), GABRP(12), GABRQ(7), GABRR1(7), GABRR2(1), GALR1(5), GALR3(2), GH1(3), GH2(10), GHR(25), GHRHR(4), GHSR(8), GIPR(2), GLP1R(11), GLP2R(14), GLRA1(11), GLRA2(5), GLRA3(12), GLRB(26), GNRHR(2), GPR156(10), GPR35(3), GPR50(17), GPR63(6), GPR83(13), GRIA1(39), GRIA2(34), GRIA3(23), GRIA4(23), GRID1(22), GRID2(51), GRIK1(22), GRIK2(20), GRIK3(28), GRIK4(11), GRIK5(10), GRIN1(7), GRIN2A(86), GRIN2B(53), GRIN2C(8), GRIN2D(6), GRIN3A(40), GRIN3B(4), GRM1(16), GRM2(7), GRM3(49), GRM4(19), GRM5(13), GRM6(24), GRM7(32), GRM8(43), GRPR(5), GZMA(11), HCRTR1(2), HCRTR2(26), HRH1(14), HRH2(3), HRH3(4), HRH4(5), HTR1A(8), HTR1B(1), HTR1D(3), HTR1E(5), HTR1F(7), HTR2A(8), HTR2B(2), HTR2C(10), HTR4(9), HTR5A(16), HTR6(1), HTR7(8), LEP(2), LEPR(22), LHCGR(24), LTB4R(1), LTB4R2(1), MAS1(3), MC2R(5), MC3R(7), MC4R(1), MC5R(7), MCHR1(3), MCHR2(14), MLNR(1), MTNR1A(8), MTNR1B(7), NMBR(6), NMUR1(6), NMUR2(14), NPBWR1(2), NPBWR2(10), NPFFR1(1), NPFFR2(11), NPY1R(25), NPY2R(12), NPY5R(22), NR3C1(7), NTSR1(6), NTSR2(3), OPRD1(2), OPRK1(21), OPRL1(5), OPRM1(5), OXTR(5), P2RX1(3), P2RX2(2), P2RX3(9), P2RX4(2), P2RX5(8), P2RX7(5), P2RY1(4), P2RY10(6), P2RY13(4), P2RY14(8), P2RY2(8), P2RY6(1), P2RY8(6), PARD3(15), PPYR1(12), PRL(1), PRLHR(1), PRLR(29), PRSS1(25), PRSS3(4), PTAFR(2), PTGDR(9), PTGER2(6), PTGER3(3), PTGER4(1), PTGFR(20), PTGIR(5), PTH2R(14), RXFP1(15), RXFP2(22), SCTR(7), SSTR1(10), SSTR2(5), SSTR3(11), SSTR4(3), SSTR5(3), TAAR1(2), TAAR2(9), TAAR5(3), TAAR6(11), TAAR8(7), TAAR9(3), TACR1(7), TACR2(7), TACR3(25), TBXA2R(4), THRA(2), THRB(14), TRHR(19), TRPV1(2), TSHB(6), TSHR(8), UTS2R(1), VIPR1(4), VIPR2(5)	73362745	2385	209	2212	1473	1692	196	78	221	196	2	7.95e-09	1.000	1.000
77	HSA04510_FOCAL_ADHESION	Genes involved in focal adhesion	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX	188	ACTB(7), ACTG1(5), ACTN1(5), ACTN2(21), ACTN3(7), ACTN4(5), AKT1(3), AKT2(8), AKT3(4), ARHGAP5(11), BCAR1(4), BCL2(2), BIRC2(5), BIRC3(7), CAPN2(6), CAV1(1), CCND1(1), CCND2(5), CCND3(2), CDC42(2), CHAD(3), COL11A1(58), COL11A2(36), COL1A1(41), COL1A2(39), COL2A1(29), COL3A1(64), COL4A1(57), COL4A2(30), COL4A4(91), COL4A6(32), COL5A1(63), COL5A2(41), COL5A3(67), COL6A1(8), COL6A2(21), COL6A3(57), COL6A6(53), COMP(7), CRK(2), CRKL(2), CTNNB1(11), DIAPH1(6), DOCK1(15), EGF(18), EGFR(22), ELK1(2), ERBB2(7), FARP2(5), FIGF(4), FLNA(15), FLNB(38), FLNC(56), FLT1(33), FN1(21), FYN(6), GRB2(2), GRLF1(12), GSK3B(2), HGF(23), HRAS(3), IBSP(7), IGF1(11), IGF1R(10), ITGA1(18), ITGA10(7), ITGA11(16), ITGA2(11), ITGA2B(10), ITGA3(7), ITGA4(36), ITGA5(20), ITGA6(8), ITGA7(23), ITGA8(36), ITGA9(13), ITGAV(9), ITGB1(4), ITGB3(11), ITGB4(20), ITGB5(6), ITGB6(11), ITGB7(6), ITGB8(17), JUN(1), KDR(42), LAMA1(37), LAMA2(56), LAMA3(56), LAMA4(11), LAMA5(27), LAMB1(9), LAMB2(11), LAMB3(23), LAMB4(37), LAMC1(10), LAMC2(20), LAMC3(6), MAP2K1(10), MAPK1(4), MAPK10(8), MAPK3(1), MAPK8(1), MAPK9(5), MET(19), MYL2(5), MYL5(1), MYL7(2), MYL9(2), MYLK(39), MYLK2(10), MYLPF(2), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PARVA(1), PARVB(3), PARVG(3), PDGFA(1), PDGFB(3), PDGFC(16), PDGFD(6), PDGFRA(27), PDGFRB(16), PDPK1(4), PGF(1), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PIP5K1C(8), PPP1CA(1), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PRKCA(10), PRKCG(13), PTK2(8), PXN(3), RAC2(1), RAF1(8), RAP1A(2), RAP1B(1), RAPGEF1(10), RELN(70), RHOA(1), ROCK1(5), ROCK2(12), SHC1(1), SHC2(7), SHC3(11), SHC4(2), SOS1(8), SOS2(11), SPP1(7), SRC(1), THBS1(27), THBS2(9), THBS3(10), THBS4(11), TLN1(12), TLN2(23), TNC(32), TNN(46), TNR(70), TNXB(132), VASP(3), VAV1(15), VAV2(3), VAV3(9), VCL(7), VEGFA(5), VEGFB(1), VTN(7), VWF(49), ZYX(6)	122750871	2914	209	2791	1268	2105	201	82	284	239	3	6.97e-08	1.000	1.000
78	HSA01430_CELL_COMMUNICATION	Genes involved in cell communication	ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF	136	ACTB(7), ACTG1(5), CHAD(3), COL11A1(58), COL11A2(36), COL17A1(27), COL1A1(41), COL1A2(39), COL2A1(29), COL3A1(64), COL4A1(57), COL4A2(30), COL4A4(91), COL4A6(32), COL5A1(63), COL5A2(41), COL5A3(67), COL6A1(8), COL6A2(21), COL6A3(57), COL6A6(53), COMP(7), DES(8), DSC1(42), DSC2(36), DSC3(37), DSG1(56), DSG2(21), DSG3(60), DSG4(56), FN1(21), GJA1(7), GJA10(13), GJA3(1), GJA4(4), GJA5(7), GJA8(18), GJA9(3), GJB1(1), GJB2(3), GJB3(3), GJB4(6), GJB5(6), GJB6(6), GJB7(2), GJC1(6), GJC3(1), GJD2(5), IBSP(7), INA(4), ITGA6(8), ITGB4(20), KRT1(19), KRT10(14), KRT12(11), KRT13(11), KRT14(2), KRT15(10), KRT16(11), KRT17(8), KRT18(3), KRT2(17), KRT20(7), KRT23(8), KRT24(7), KRT25(10), KRT27(5), KRT28(10), KRT3(13), KRT31(8), KRT32(10), KRT33A(5), KRT33B(3), KRT34(10), KRT35(8), KRT36(16), KRT37(11), KRT38(8), KRT39(12), KRT4(17), KRT40(6), KRT5(15), KRT6A(16), KRT6B(8), KRT6C(13), KRT7(5), KRT71(15), KRT72(11), KRT73(15), KRT74(13), KRT75(14), KRT76(12), KRT77(13), KRT78(19), KRT79(8), KRT8(6), KRT81(3), KRT82(8), KRT83(14), KRT84(10), KRT85(7), KRT86(7), KRT9(19), LAMA1(37), LAMA2(56), LAMA3(56), LAMA4(11), LAMA5(27), LAMB1(9), LAMB2(11), LAMB3(23), LAMB4(37), LAMC1(10), LAMC2(20), LAMC3(6), LMNA(8), LMNB1(2), LMNB2(4), NES(21), PRPH(1), RELN(70), SPP1(7), THBS1(27), THBS2(9), THBS3(10), THBS4(11), TNC(32), TNN(46), TNR(70), TNXB(132), VIM(5), VTN(7), VWF(49)	83420384	2649	204	2524	1115	1992	194	62	206	194	1	3.07e-11	1.000	1.000
79	HSA04020_CALCIUM_SIGNALING_PATHWAY	Genes involved in calcium signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3	167	ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY7(10), ADCY8(45), ADCY9(9), ADORA2A(2), ADORA2B(1), ADRA1A(8), ADRA1B(3), ADRA1D(4), ADRB1(5), ADRB2(2), AGTR1(10), ATP2A1(9), ATP2A2(12), ATP2A3(14), ATP2B1(6), ATP2B2(24), ATP2B3(9), ATP2B4(15), AVPR1A(4), AVPR1B(9), BDKRB1(5), BDKRB2(9), BST1(1), CACNA1A(32), CACNA1B(26), CACNA1C(43), CACNA1D(29), CACNA1E(97), CACNA1F(20), CACNA1G(30), CACNA1H(23), CACNA1I(33), CACNA1S(46), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CAMK4(10), CCKAR(9), CCKBR(10), CD38(4), CHP(3), CHRM1(5), CHRM2(18), CHRM3(19), CHRM5(4), CHRNA7(3), CYSLTR1(4), CYSLTR2(2), DRD1(8), EDNRA(8), EDNRB(4), EGFR(22), ERBB2(7), ERBB3(5), ERBB4(47), F2R(6), GNA11(7), GNA14(5), GNA15(5), GNAL(2), GNAQ(4), GNAS(19), GRIN1(7), GRIN2A(86), GRIN2C(8), GRIN2D(6), GRM1(16), GRM5(13), GRPR(5), HRH1(14), HRH2(3), HTR2A(8), HTR2B(2), HTR2C(10), HTR4(9), HTR5A(16), HTR6(1), HTR7(8), ITPKB(7), ITPR1(29), ITPR2(17), ITPR3(6), LHCGR(24), LTB4R2(1), MYLK(39), MYLK2(10), NOS1(58), NOS3(16), NTSR1(6), OXTR(5), P2RX1(3), P2RX2(2), P2RX3(9), P2RX4(2), P2RX5(8), P2RX7(5), PDE1B(12), PDE1C(41), PDGFRA(27), PDGFRB(16), PHKA1(19), PHKA2(7), PHKB(7), PHKG1(1), PHKG2(2), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PLCD1(3), PLCD3(3), PLCD4(2), PLCE1(48), PLCG1(9), PLCG2(25), PLCZ1(20), PPID(1), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PRKACA(3), PRKACB(4), PRKACG(8), PRKCA(10), PRKCG(13), PRKX(3), PTAFR(2), PTGER3(3), PTGFR(20), PTK2B(10), RYR1(87), RYR2(84), RYR3(81), SLC25A6(2), SLC8A1(27), SLC8A2(9), SLC8A3(34), SPHK1(1), SPHK2(7), TACR1(7), TACR2(7), TACR3(25), TBXA2R(4), TNNC1(2), TNNC2(3), TRHR(19), TRPC1(5), VDAC1(1), VDAC2(1), VDAC3(1)	88453764	2235	203	2115	1474	1603	160	76	193	199	4	0.0367	1.000	1.000
80	HSA04512_ECM_RECEPTOR_INTERACTION	Genes involved in ECM-receptor interaction	AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF	85	AGRN(12), CD36(4), CD44(5), CD47(1), CHAD(3), COL11A1(58), COL11A2(36), COL1A1(41), COL1A2(39), COL2A1(29), COL3A1(64), COL4A1(57), COL4A2(30), COL4A4(91), COL4A6(32), COL5A1(63), COL5A2(41), COL5A3(67), COL6A1(8), COL6A2(21), COL6A3(57), COL6A6(53), DAG1(5), FN1(21), FNDC1(32), FNDC3A(9), FNDC4(5), FNDC5(3), GP5(4), GP6(5), GP9(6), HMMR(4), HSPG2(24), IBSP(7), ITGA1(18), ITGA10(7), ITGA11(16), ITGA2(11), ITGA2B(10), ITGA3(7), ITGA4(36), ITGA5(20), ITGA6(8), ITGA7(23), ITGA8(36), ITGA9(13), ITGAV(9), ITGB1(4), ITGB3(11), ITGB4(20), ITGB5(6), ITGB6(11), ITGB7(6), ITGB8(17), LAMA1(37), LAMA2(56), LAMA3(56), LAMA4(11), LAMA5(27), LAMB1(9), LAMB2(11), LAMB3(23), LAMB4(37), LAMC1(10), LAMC2(20), LAMC3(6), RELN(70), SDC1(3), SDC2(2), SDC3(6), SDC4(3), SPP1(7), SV2A(16), SV2B(29), SV2C(14), THBS1(27), THBS2(9), THBS3(10), THBS4(11), TNC(32), TNN(46), TNR(70), TNXB(132), VTN(7), VWF(49)	74870946	2072	202	1988	871	1552	121	61	170	167	1	0.000160	1.000	1.000
81	HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	Genes involved in cytokine-cytokine receptor interaction	ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1	249	ACVR1(2), ACVR1B(3), ACVR2A(3), ACVR2B(3), AMHR2(15), BMP2(4), BMP7(2), BMPR1A(2), BMPR1B(3), BMPR2(5), CCL1(1), CCL11(1), CCL14(2), CCL15(3), CCL16(1), CCL18(1), CCL2(1), CCL20(2), CCL21(2), CCL22(1), CCL24(3), CCL25(1), CCL26(1), CCL27(2), CCL28(1), CCL7(4), CCL8(3), CCR1(9), CCR2(16), CCR3(10), CCR4(7), CCR5(7), CCR6(2), CCR7(3), CCR8(6), CCR9(5), CD27(3), CD40(4), CD40LG(2), CLCF1(1), CNTF(1), CNTFR(3), CSF1(10), CSF1R(12), CSF2(2), CSF2RA(17), CSF2RB(17), CSF3(4), CSF3R(6), CX3CL1(4), CX3CR1(13), CXCL10(3), CXCL11(1), CXCL12(2), CXCL13(1), CXCL14(1), CXCL3(1), CXCL5(2), CXCL6(1), CXCL9(2), CXCR3(4), CXCR4(3), CXCR6(4), EDA(2), EDA2R(3), EDAR(5), EGF(18), EGFR(22), EPO(5), EPOR(1), FAS(5), FASLG(14), FLT1(33), FLT3(31), FLT3LG(2), FLT4(23), GDF5(13), GH1(3), GH2(10), GHR(25), HGF(23), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(9), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(5), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IFNG(2), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(4), IL10(3), IL10RA(7), IL10RB(5), IL11(2), IL11RA(3), IL12A(3), IL12B(3), IL12RB1(15), IL12RB2(3), IL13(2), IL13RA1(3), IL15(3), IL15RA(6), IL17A(9), IL17B(3), IL17RA(4), IL17RB(2), IL18(2), IL18R1(17), IL18RAP(16), IL19(2), IL1A(4), IL1B(6), IL1R1(11), IL1R2(7), IL1RAP(4), IL2(4), IL20(4), IL20RA(9), IL21(6), IL21R(17), IL22(1), IL22RA1(11), IL22RA2(1), IL23A(2), IL23R(7), IL25(2), IL26(3), IL28A(1), IL28B(4), IL28RA(4), IL29(1), IL2RA(4), IL2RB(7), IL2RG(3), IL3(3), IL3RA(7), IL4(1), IL4R(13), IL5(4), IL5RA(12), IL6(2), IL6R(4), IL6ST(10), IL7(5), IL7R(27), IL8(1), IL9(1), IL9R(5), INHBA(16), INHBB(7), INHBC(11), INHBE(3), KDR(42), KIT(9), KITLG(8), LEP(2), LEPR(22), LIF(2), LIFR(33), LTA(2), LTB(2), MET(19), MPL(7), NGFR(7), OSM(5), OSMR(35), PDGFB(3), PDGFC(16), PDGFRA(27), PDGFRB(16), PLEKHO2(5), PPBP(5), PRL(1), PRLR(29), RELT(2), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(8), TNF(1), TNFRSF10A(5), TNFRSF10B(2), TNFRSF10C(4), TNFRSF10D(7), TNFRSF11A(5), TNFRSF11B(10), TNFRSF12A(1), TNFRSF13B(8), TNFRSF14(2), TNFRSF17(6), TNFRSF18(4), TNFRSF19(2), TNFRSF1A(3), TNFRSF1B(3), TNFRSF21(10), TNFRSF25(5), TNFRSF4(4), TNFRSF6B(2), TNFRSF8(17), TNFRSF9(4), TNFSF10(7), TNFSF11(4), TNFSF12(1), TNFSF13B(1), TNFSF14(7), TNFSF15(7), TNFSF18(7), TNFSF4(3), TNFSF8(3), TNFSF9(1), TPO(40), TSLP(1), VEGFA(5), VEGFB(1), XCL1(1), XCL2(2), XCR1(4)	58721906	1452	201	1397	797	1042	100	38	131	141	0	0.0391	1.000	1.000
82	HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON	Genes involved in regulation of actin cytoskeleton	ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL	199	ACTN1(5), ACTN2(21), ACTN3(7), ACTN4(5), APC(19), APC2(9), ARAF(4), ARHGEF1(1), ARHGEF12(11), ARHGEF4(4), ARHGEF6(10), ARHGEF7(3), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), ARPC5(1), BAIAP2(5), BCAR1(4), BDKRB1(5), BDKRB2(9), CD14(5), CDC42(2), CFL1(1), CHRM1(5), CHRM2(18), CHRM3(19), CHRM4(6), CHRM5(4), CRK(2), CRKL(2), CSK(1), CYFIP1(7), CYFIP2(23), DIAPH1(6), DIAPH2(7), DIAPH3(11), DOCK1(15), EGF(18), EGFR(22), EZR(1), F2(9), F2R(6), FGD1(3), FGD3(8), FGF1(1), FGF10(2), FGF11(2), FGF12(12), FGF13(6), FGF14(5), FGF17(2), FGF18(2), FGF19(3), FGF2(2), FGF21(4), FGF23(8), FGF3(5), FGF4(2), FGF5(5), FGF6(6), FGF7(7), FGF8(1), FGF9(4), FGFR1(11), FGFR2(31), FGFR3(9), FGFR4(9), FN1(21), GIT1(4), GNA12(3), GNA13(1), GRLF1(12), GSN(6), HRAS(3), IQGAP1(10), IQGAP2(22), IQGAP3(10), ITGA1(18), ITGA10(7), ITGA11(16), ITGA2(11), ITGA2B(10), ITGA3(7), ITGA4(36), ITGA5(20), ITGA6(8), ITGA7(23), ITGA8(36), ITGA9(13), ITGAD(24), ITGAE(16), ITGAL(24), ITGAM(21), ITGAV(9), ITGAX(18), ITGB1(4), ITGB2(13), ITGB3(11), ITGB4(20), ITGB5(6), ITGB6(11), ITGB7(6), ITGB8(17), KRAS(4), LIMK1(4), LIMK2(9), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), MOS(5), MRAS(1), MSN(1), MYH10(13), MYH14(17), MYH9(12), MYL2(5), MYL5(1), MYL7(2), MYL9(2), MYLK(39), MYLK2(10), MYLPF(2), NCKAP1(5), NCKAP1L(30), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PDGFA(1), PDGFB(3), PDGFRA(27), PDGFRB(16), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PIP4K2A(5), PIP4K2B(3), PIP4K2C(3), PIP5K1A(6), PIP5K1B(18), PIP5K1C(8), PPP1CA(1), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PPP1R12B(8), PTK2(8), PXN(3), RAC2(1), RAF1(8), RDX(1), RHOA(1), ROCK1(5), ROCK2(12), RRAS(1), SCIN(7), SLC9A1(3), SOS1(8), SOS2(11), SSH1(14), SSH2(7), SSH3(3), TIAM1(25), TIAM2(27), TMSL3(2), VAV1(15), VAV2(3), VAV3(9), VCL(7), WAS(7), WASF1(4), WASF2(4), WASL(5)	90938229	1616	200	1558	824	1083	109	57	209	154	4	0.00221	1.000	1.000
83	HSA04010_MAPK_SIGNALING_PATHWAY	Genes involved in MAPK signaling pathway	ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK	242	ACVR1B(3), ACVR1C(9), AKT1(3), AKT2(8), AKT3(4), ARRB1(3), ARRB2(6), ATF2(5), ATF4(7), BDNF(3), CACNA1A(32), CACNA1B(26), CACNA1C(43), CACNA1D(29), CACNA1E(97), CACNA1F(20), CACNA1G(30), CACNA1H(23), CACNA1I(33), CACNA1S(46), CACNA2D1(10), CACNA2D2(14), CACNA2D3(45), CACNA2D4(18), CACNB1(4), CACNB2(12), CACNB3(2), CACNB4(11), CACNG1(3), CACNG2(9), CACNG3(19), CACNG4(3), CACNG5(10), CACNG6(5), CACNG7(5), CACNG8(1), CASP3(2), CD14(5), CDC25B(4), CDC42(2), CHP(3), CHUK(2), CRK(2), CRKL(2), DAXX(9), DDIT3(2), DUSP10(6), DUSP14(2), DUSP16(4), DUSP2(1), DUSP3(1), DUSP4(1), DUSP5(2), DUSP6(1), DUSP7(2), DUSP8(3), DUSP9(3), ECSIT(2), EGF(18), EGFR(22), ELK1(2), ELK4(7), FAS(5), FASLG(14), FGF1(1), FGF10(2), FGF11(2), FGF12(12), FGF13(6), FGF14(5), FGF17(2), FGF18(2), FGF19(3), FGF2(2), FGF21(4), FGF23(8), FGF3(5), FGF4(2), FGF5(5), FGF6(6), FGF7(7), FGF8(1), FGF9(4), FGFR1(11), FGFR2(31), FGFR3(9), FGFR4(9), FLNA(15), FLNB(38), FLNC(56), FOS(2), GADD45B(2), GNA12(3), GRB2(2), HRAS(3), IKBKB(3), IL1A(4), IL1B(6), IL1R1(11), IL1R2(7), JUN(1), JUND(1), KRAS(4), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K5(3), MAP2K6(3), MAP2K7(4), MAP3K1(2), MAP3K10(8), MAP3K12(3), MAP3K13(10), MAP3K14(3), MAP3K2(6), MAP3K3(6), MAP3K4(17), MAP3K5(16), MAP3K6(6), MAP3K7(1), MAP4K1(9), MAP4K2(6), MAP4K3(8), MAP4K4(7), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK7(4), MAPK8(1), MAPK8IP1(4), MAPK8IP2(7), MAPK8IP3(8), MAPK9(5), MAPKAPK2(7), MAPKAPK3(3), MAPKAPK5(1), MAPT(10), MEF2C(2), MKNK1(5), MKNK2(2), MOS(5), MRAS(1), MYC(5), NF1(40), NFATC2(9), NFATC4(13), NFKB1(7), NFKB2(4), NLK(5), NR4A1(3), NTF3(6), NTRK1(15), NTRK2(9), PAK1(4), PAK2(8), PDGFA(1), PDGFB(3), PDGFRA(27), PDGFRB(16), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PPM1A(3), PPM1B(7), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PPP5C(2), PRKACA(3), PRKACB(4), PRKACG(8), PRKCA(10), PRKCG(13), PRKX(3), PTPN5(11), PTPN7(2), PTPRR(24), RAC2(1), RAF1(8), RAP1A(2), RAP1B(1), RAPGEF2(9), RASA1(4), RASA2(14), RASGRF1(20), RASGRF2(19), RASGRP1(7), RASGRP2(6), RASGRP3(13), RASGRP4(10), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KA4(4), RPS6KA5(4), RPS6KA6(15), RRAS(1), SOS1(8), SOS2(11), SRF(2), STK4(3), STMN1(3), TAOK1(11), TAOK2(24), TAOK3(3), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(8), TNF(1), TNFRSF1A(3), TRAF2(2), TRAF6(4), ZAK(6)	93126872	1845	199	1772	1090	1222	173	60	198	187	5	0.488	1.000	1.000
84	HSA04360_AXON_GUIDANCE	Genes involved in axon guidance	ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D	125	ABL1(12), ABLIM1(12), ABLIM2(6), ABLIM3(7), ARHGEF12(11), CDC42(2), CDK5(4), CFL1(1), CHP(3), CXCL12(2), CXCR4(3), DCC(76), DPYSL2(4), DPYSL5(11), EFNA2(1), EFNA4(2), EFNA5(3), EFNB1(1), EFNB3(2), EPHA1(15), EPHA2(15), EPHA3(25), EPHA4(17), EPHA5(7), EPHA6(60), EPHA7(42), EPHA8(16), EPHB1(25), EPHB2(29), EPHB3(14), EPHB4(10), EPHB6(22), FES(5), FYN(6), GNAI1(1), GNAI2(5), GNAI3(2), GSK3B(2), HRAS(3), ITGB1(4), KRAS(4), L1CAM(8), LIMK1(4), LIMK2(9), LRRC4C(39), MAPK1(4), MAPK3(1), MET(19), NCK1(1), NCK2(4), NFAT5(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NGEF(13), NRP1(18), NTN4(16), NTNG1(14), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PLXNA1(14), PLXNA2(9), PLXNA3(10), PLXNB1(20), PLXNB2(16), PLXNB3(6), PLXNC1(16), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PTK2(8), RAC2(1), RASA1(4), RGS3(12), RHOA(1), RHOD(2), RND1(5), ROBO1(22), ROBO2(33), ROBO3(14), ROCK1(5), ROCK2(12), SEMA3A(11), SEMA3B(2), SEMA3C(3), SEMA3D(11), SEMA3E(22), SEMA3F(10), SEMA3G(13), SEMA4A(8), SEMA4B(4), SEMA4C(7), SEMA4D(9), SEMA4F(6), SEMA4G(8), SEMA5A(18), SEMA5B(16), SEMA6A(8), SEMA6B(7), SEMA6C(8), SEMA6D(4), SEMA7A(3), SLIT1(16), SLIT2(56), SLIT3(45), SRGAP1(6), SRGAP2(7), SRGAP3(32), UNC5A(8), UNC5B(9), UNC5C(16), UNC5D(23)	64785387	1395	194	1327	731	971	108	38	157	119	2	0.0157	1.000	1.000
85	HSA04630_JAK_STAT_SIGNALING_PATHWAY	Genes involved in Jak-STAT signaling pathway	AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2	151	AKT1(3), AKT2(8), AKT3(4), CBL(8), CBLB(16), CBLC(14), CCND1(1), CCND2(5), CCND3(2), CISH(3), CLCF1(1), CNTF(1), CNTFR(3), CREBBP(20), CSF2(2), CSF2RA(17), CSF2RB(17), CSF3(4), CSF3R(6), EP300(14), EPO(5), EPOR(1), GH1(3), GH2(10), GHR(25), GRB2(2), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(9), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(5), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IFNG(2), IFNGR1(4), IFNGR2(4), IFNK(2), IFNW1(4), IL10(3), IL10RA(7), IL10RB(5), IL11(2), IL11RA(3), IL12A(3), IL12B(3), IL12RB1(15), IL12RB2(3), IL13(2), IL13RA1(3), IL13RA2(3), IL15(3), IL15RA(6), IL19(2), IL2(4), IL20(4), IL20RA(9), IL21(6), IL21R(17), IL22(1), IL22RA1(11), IL22RA2(1), IL23A(2), IL23R(7), IL26(3), IL28A(1), IL28B(4), IL28RA(4), IL29(1), IL2RA(4), IL2RB(7), IL2RG(3), IL3(3), IL3RA(7), IL4(1), IL4R(13), IL5(4), IL5RA(12), IL6(2), IL6R(4), IL6ST(10), IL7(5), IL7R(27), IL9(1), IL9R(5), IRF9(1), JAK1(6), JAK2(9), JAK3(6), LEP(2), LEPR(22), LIF(2), LIFR(33), MPL(7), MYC(5), OSM(5), OSMR(35), PIAS1(5), PIAS2(5), PIAS3(5), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PIM1(1), PRL(1), PRLR(29), PTPN11(9), PTPN6(3), SOCS2(2), SOCS3(2), SOCS4(3), SOCS5(5), SOCS7(4), SOS1(8), SOS2(11), SPRED1(5), SPRED2(2), SPRY1(7), SPRY2(4), SPRY3(11), SPRY4(1), STAM(4), STAM2(1), STAT1(4), STAT2(8), STAT3(10), STAT4(22), STAT5A(2), STAT5B(4), STAT6(7), TPO(40), TSLP(1), TYK2(7)	48583509	963	191	929	451	638	75	37	117	95	1	0.0199	1.000	1.000
86	CALCIUM_REGULATION_IN_CARDIAC_CELLS		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	139	ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADCY9(9), ADRA1A(8), ADRA1B(3), ADRA1D(4), ADRB1(5), ADRB2(2), ANXA6(6), ARRB1(3), ARRB2(6), ATP1A4(12), ATP1B1(1), ATP1B3(1), ATP2A2(12), ATP2A3(14), ATP2B1(6), ATP2B2(24), ATP2B3(9), CACNA1A(32), CACNA1B(26), CACNA1C(43), CACNA1D(29), CACNA1E(97), CACNA1S(46), CACNB1(4), CACNB3(2), CALM1(1), CALM2(1), CALR(1), CAMK1(4), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CAMK4(10), CASQ1(8), CASQ2(4), CHRM1(5), CHRM2(18), CHRM3(19), CHRM4(6), CHRM5(4), GJA1(7), GJA4(4), GJA5(7), GJB1(1), GJB2(3), GJB3(3), GJB4(6), GJB5(6), GJB6(6), GNA11(7), GNAI2(5), GNAI3(2), GNAO1(2), GNAQ(4), GNAZ(6), GNB2(1), GNB3(7), GNB4(3), GNB5(2), GNG2(3), GNG4(2), GNG7(2), GRK4(8), GRK5(4), GRK6(3), ITPR1(29), ITPR2(17), ITPR3(6), KCNB1(31), KCNJ3(18), KCNJ5(12), MIB1(5), NME7(4), PKIA(3), PKIB(1), PKIG(1), PLCB3(4), PRKACA(3), PRKACB(4), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), PRKCD(4), PRKCE(6), PRKCG(13), PRKCH(10), PRKCQ(16), PRKCZ(5), PRKD1(3), RGS1(3), RGS11(2), RGS14(3), RGS16(2), RGS18(8), RGS20(2), RGS3(12), RGS4(2), RGS5(2), RGS6(14), RGS7(36), RGS9(10), RYR1(87), RYR2(84), RYR3(81), SFN(1), SLC8A1(27), SLC8A3(34), USP5(4), YWHAB(1), YWHAQ(3)	62094424	1357	190	1285	967	943	126	54	117	114	3	0.817	1.000	1.000
87	SMOOTH_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1	138	ACTA1(4), ACTA2(4), ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADCY9(9), ARRB1(3), ARRB2(6), ATF1(4), ATF2(5), ATF4(7), ATF5(7), ATP2A2(12), ATP2A3(14), CACNB3(2), CALCA(2), CALM1(1), CALM2(1), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CNN1(5), CNN2(2), CORIN(26), CREB3(1), CRH(3), CRHR1(6), DGKZ(7), ETS2(8), FOS(2), GABPA(1), GABPB2(8), GBA2(2), GJA1(7), GNAQ(4), GNB2(1), GNB3(7), GNB4(3), GNB5(2), GNG2(3), GNG4(2), GNG7(2), GRK4(8), GRK5(4), GRK6(3), GSTO1(2), GUCA2A(1), GUCA2B(1), GUCY1A3(29), IGFBP1(3), IGFBP2(2), IGFBP3(2), IGFBP6(2), IL1B(6), IL6(2), ITPR1(29), ITPR2(17), ITPR3(6), JUN(1), MIB1(5), MYL2(5), MYL4(5), MYLK2(10), NFKB1(7), NOS1(58), NOS3(16), OXTR(5), PDE4B(7), PDE4D(7), PKIA(3), PKIB(1), PKIG(1), PLCB3(4), PLCD1(3), PLCG1(9), PLCG2(25), PRKACA(3), PRKACB(4), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), PRKCD(4), PRKCE(6), PRKCH(10), PRKCQ(16), PRKCZ(5), PRKD1(3), RAMP1(1), RAMP2(1), RAMP3(2), RGS1(3), RGS11(2), RGS14(3), RGS16(2), RGS18(8), RGS20(2), RGS3(12), RGS4(2), RGS5(2), RGS6(14), RGS7(36), RGS9(10), RLN1(3), RYR1(87), RYR2(84), RYR3(81), SFN(1), SLC8A1(27), SP1(5), TNXB(132), USP5(4), YWHAB(1), YWHAQ(3)	58018431	1206	190	1142	717	851	101	42	114	95	3	0.0599	1.000	1.000
88	HSA04530_TIGHT_JUNCTION	Genes involved in tight junction	ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK	129	ACTB(7), ACTG1(5), ACTN1(5), ACTN2(21), ACTN3(7), ACTN4(5), AKT1(3), AKT2(8), AKT3(4), AMOTL1(2), ASH1L(26), CASK(4), CDC42(2), CDK4(5), CGN(8), CLDN1(5), CLDN10(5), CLDN11(4), CLDN14(5), CLDN16(7), CLDN17(5), CLDN18(7), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(1), CLDN4(10), CLDN6(8), CLDN7(2), CLDN8(3), CLDN9(1), CRB3(1), CSDA(3), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(23), CTNNA3(28), CTNNB1(11), CTTN(2), EPB41(8), EPB41L1(10), EPB41L2(18), EPB41L3(6), EXOC3(3), EXOC4(9), F11R(5), GNAI1(1), GNAI2(5), GNAI3(2), HCLS1(9), HRAS(3), IGSF5(10), INADL(39), JAM2(10), JAM3(2), KRAS(4), LLGL1(4), LLGL2(13), MAGI1(26), MAGI2(22), MAGI3(12), MLLT4(13), MPDZ(12), MPP5(1), MRAS(1), MYH1(85), MYH10(13), MYH11(26), MYH13(36), MYH14(17), MYH15(53), MYH2(77), MYH3(21), MYH4(80), MYH6(32), MYH7(43), MYH7B(25), MYH8(52), MYH9(12), MYL2(5), MYL5(1), MYL7(2), MYL9(2), MYLPF(2), OCLN(4), PARD3(15), PARD6A(1), PARD6B(1), PARD6G(3), PPM1J(1), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(6), PPP2R3A(7), PPP2R3B(4), PPP2R4(2), PRKCA(10), PRKCD(4), PRKCE(6), PRKCG(13), PRKCH(10), PRKCI(8), PRKCQ(16), PRKCZ(5), RAB3B(1), RHOA(1), RRAS(1), SPTAN1(7), SRC(1), SYMPK(5), TJAP1(3), TJP1(11), TJP2(8), TJP3(18), VAPA(1), YES1(5), ZAK(6)	64136084	1291	189	1229	816	894	114	42	132	106	3	0.603	1.000	1.000
89	HSA04310_WNT_SIGNALING_PATHWAY	Genes involved in Wnt signaling pathway	APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	142	APC(19), APC2(9), AXIN1(10), AXIN2(3), BTRC(4), CACYBP(2), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CCND1(1), CCND2(5), CCND3(2), CER1(12), CHD8(21), CHP(3), CREBBP(20), CSNK1A1(2), CSNK1A1L(5), CSNK1E(4), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), CTBP2(1), CTNNB1(11), CTNNBIP1(1), CUL1(5), CXXC4(1), DAAM1(5), DAAM2(5), DKK1(2), DKK2(14), DKK4(3), DVL2(3), DVL3(7), EP300(14), FBXW11(5), FZD1(4), FZD10(2), FZD2(5), FZD4(1), FZD5(2), FZD6(2), FZD7(4), FZD8(4), FZD9(1), GSK3B(2), JUN(1), LEF1(3), LRP5(18), LRP6(21), MAP3K7(1), MAPK10(8), MAPK8(1), MAPK9(5), MMP7(4), MYC(5), NFAT5(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NKD1(8), NKD2(5), NLK(5), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PORCN(4), PPARD(3), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(6), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PRICKLE1(9), PRICKLE2(5), PRKACA(3), PRKACB(4), PRKACG(8), PRKCA(10), PRKCG(13), PRKX(3), PSEN1(1), RAC2(1), RHOA(1), ROCK1(5), ROCK2(12), RUVBL1(1), SENP2(11), SFRP1(2), SFRP2(9), SFRP4(6), SMAD2(3), SMAD3(2), SMAD4(2), SOX17(6), TBL1X(5), TBL1XR1(1), TBL1Y(7), TCF7(1), TCF7L1(3), TCF7L2(7), VANGL1(2), VANGL2(8), WIF1(7), WNT1(2), WNT10A(7), WNT10B(5), WNT11(4), WNT16(1), WNT2(7), WNT2B(4), WNT3(5), WNT3A(6), WNT4(2), WNT5A(5), WNT5B(5), WNT6(2), WNT7A(13), WNT7B(6), WNT8A(7), WNT8B(7), WNT9A(3), WNT9B(3)	53190280	814	184	785	404	520	69	35	111	78	1	0.114	1.000	1.000
90	GPCRDB_CLASS_A_RHODOPSIN_LIKE		ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR	162	ADORA1(6), ADORA2A(2), ADORA2B(1), ADORA3(12), ADRA1A(8), ADRA1B(3), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(2), AGTR1(10), AGTR2(9), AVPR1A(4), AVPR1B(9), AVPR2(1), BDKRB1(5), BDKRB2(9), BRS3(5), C3AR1(4), CCBP2(8), CCKAR(9), CCKBR(10), CCR1(9), CCR10(2), CCR2(16), CCR3(10), CCR4(7), CCR5(7), CCR6(2), CCR7(3), CCR8(6), CCR9(5), CCRL2(5), CHML(4), CHRM1(5), CHRM2(18), CHRM3(19), CHRM4(6), CHRM5(4), CMKLR1(12), CNR1(9), CNR2(4), CX3CR1(13), CXCR3(4), CXCR4(3), DRD1(8), DRD2(15), DRD3(5), DRD4(1), DRD5(22), EDNRA(8), EDNRB(4), F2R(6), F2RL1(15), F2RL2(6), F2RL3(3), FPR1(18), FSHR(15), GALR1(5), GALR3(2), GALT(2), GHSR(8), GNB2L1(3), GPR17(1), GPR173(1), GPR174(12), GPR27(2), GPR3(2), GPR35(3), GPR37(9), GPR37L1(6), GPR4(4), GPR50(17), GPR6(6), GPR63(6), GPR77(5), GPR83(13), GPR85(5), GPR87(4), GRPR(5), HCRTR1(2), HCRTR2(26), HRH1(14), HRH2(3), HRH3(4), HTR1A(8), HTR1B(1), HTR1D(3), HTR1E(5), HTR1F(7), HTR2A(8), HTR2B(2), HTR2C(10), HTR4(9), HTR5A(16), HTR6(1), HTR7(8), LHCGR(24), LTB4R(1), MAS1(3), MC3R(7), MC4R(1), MC5R(7), MLNR(1), MTNR1A(8), MTNR1B(7), NMBR(6), NMUR1(6), NMUR2(14), NPY1R(25), NPY2R(12), NPY5R(22), NTSR1(6), NTSR2(3), OPN1SW(2), OPN3(3), OPRD1(2), OPRK1(21), OPRL1(5), OPRM1(5), OR10A5(7), OR11A1(6), OR12D3(5), OR1C1(9), OR1F1(5), OR1Q1(7), OR2H1(7), OR5V1(9), OR7A5(2), OR7C1(2), OR8B8(10), OXTR(5), P2RY1(4), P2RY10(6), P2RY12(3), P2RY13(4), P2RY14(8), P2RY2(8), P2RY6(1), PPYR1(12), PTAFR(2), PTGDR(9), PTGER2(6), PTGER4(1), PTGFR(20), PTGIR(5), RGR(5), RHO(2), RRH(1), SSTR1(10), SSTR2(5), SSTR3(11), SSTR4(3), SUCNR1(9), TBXA2R(4), TRHR(19)	40407007	1101	183	1042	822	750	110	36	128	77	0	0.00224	1.000	1.000
91	HSA04514_CELL_ADHESION_MOLECULES	Genes involved in cell adhesion molecules (CAMs)	ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN	129	ALCAM(5), CADM1(3), CADM3(17), CD22(22), CD226(6), CD274(1), CD276(6), CD28(1), CD34(4), CD4(6), CD40(4), CD40LG(2), CD58(1), CD6(7), CD80(4), CD86(19), CD8A(2), CD8B(7), CD99(1), CDH1(5), CDH15(9), CDH2(12), CDH4(28), CDH5(9), CLDN1(5), CLDN10(5), CLDN11(4), CLDN14(5), CLDN16(7), CLDN17(5), CLDN18(7), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(1), CLDN4(10), CLDN6(8), CLDN7(2), CLDN8(3), CLDN9(1), CNTN1(22), CNTN2(14), CNTNAP1(11), CNTNAP2(76), CTLA4(2), ESAM(3), F11R(5), GLG1(5), HLA-A(6), HLA-B(5), HLA-C(1), HLA-DMA(4), HLA-DMB(7), HLA-DOA(4), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(7), HLA-DQB1(5), HLA-DRA(11), HLA-DRB1(3), HLA-DRB5(1), HLA-E(1), HLA-F(6), HLA-G(3), ICAM1(2), ICAM2(4), ICAM3(2), ICOS(3), ICOSLG(2), ITGA4(36), ITGA6(8), ITGA8(36), ITGA9(13), ITGAL(24), ITGAM(21), ITGAV(9), ITGB1(4), ITGB2(13), ITGB7(6), ITGB8(17), JAM2(10), JAM3(2), L1CAM(8), MADCAM1(1), MAG(11), MPZ(4), MPZL1(1), NCAM1(10), NCAM2(8), NEGR1(6), NEO1(12), NFASC(39), NLGN1(10), NLGN2(5), NLGN3(6), NRCAM(8), NRXN1(44), NRXN2(15), NRXN3(27), OCLN(4), PDCD1(3), PDCD1LG2(3), PTPRC(30), PTPRF(27), PTPRM(7), PVR(3), PVRL1(4), PVRL2(5), PVRL3(5), SDC1(3), SDC2(2), SDC3(6), SDC4(3), SELE(34), SELL(8), SELP(30), SELPLG(8), SIGLEC1(24), SPN(5), VCAM1(16), VCAN(34)	48587132	1159	183	1110	552	810	87	44	128	90	0	8.92e-05	1.000	1.000
92	HSA04540_GAP_JUNCTION	Genes involved in gap junction	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8	91	ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADCY9(9), ADRB1(5), CSNK1D(1), DRD1(8), DRD2(15), EGF(18), EGFR(22), GJA1(7), GJD2(5), GNA11(7), GNAI1(1), GNAI2(5), GNAI3(2), GNAQ(4), GNAS(19), GRB2(2), GRM1(16), GRM5(13), GUCY1A2(18), GUCY1A3(29), GUCY1B3(7), GUCY2C(32), GUCY2D(8), GUCY2F(15), HRAS(3), HTR2A(8), HTR2B(2), HTR2C(10), ITPR1(29), ITPR2(17), ITPR3(6), KRAS(4), MAP2K1(10), MAP2K2(3), MAP2K5(3), MAP3K2(6), MAPK1(4), MAPK3(1), MAPK7(4), NPR1(16), NPR2(14), PDGFA(1), PDGFB(3), PDGFC(16), PDGFD(6), PDGFRA(27), PDGFRB(16), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PRKACA(3), PRKACB(4), PRKACG(8), PRKCA(10), PRKCG(13), PRKG1(12), PRKG2(13), PRKX(3), RAF1(8), SOS1(8), SOS2(11), SRC(1), TJP1(11), TUBA1A(2), TUBA1B(4), TUBA1C(2), TUBA3C(21), TUBA3D(11), TUBA3E(3), TUBA4A(6), TUBA8(3), TUBAL3(11), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(5), TUBB4(3), TUBB4Q(9), TUBB6(10), TUBB8(13)	43743365	939	179	879	540	651	74	39	98	76	1	0.0461	1.000	1.000
93	HSA00230_PURINE_METABOLISM	Genes involved in purine metabolism	ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1	140	ADA(2), ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADCY9(9), ADK(4), ADSL(6), ADSS(2), ADSSL1(8), AK1(1), AK2(3), AK5(6), AK7(22), ALLC(7), AMPD1(28), AMPD2(5), AMPD3(22), APRT(3), ATIC(5), CANT1(9), DGUOK(4), ENPP1(11), ENPP3(14), ENTPD1(10), ENTPD2(4), ENTPD3(6), ENTPD4(4), ENTPD5(1), ENTPD6(4), ENTPD8(2), FHIT(2), GART(9), GDA(12), GMPR2(1), GMPS(4), GUCY1A2(18), GUCY1A3(29), GUCY1B3(7), GUCY2C(32), GUCY2D(8), GUCY2F(15), GUK1(2), IMPDH1(2), IMPDH2(1), NME6(2), NME7(4), NPR1(16), NPR2(14), NT5C1A(3), NT5C1B(22), NT5C2(3), NT5C3(2), NT5E(4), NT5M(2), NUDT5(2), NUDT9(2), PAICS(1), PAPSS1(3), PAPSS2(5), PDE10A(12), PDE11A(17), PDE1C(41), PDE2A(13), PDE3B(6), PDE4A(9), PDE4B(7), PDE4C(16), PDE4D(7), PDE5A(8), PDE6D(2), PDE6G(2), PDE7A(1), PDE7B(16), PDE8A(2), PDE8B(21), PDE9A(9), PFAS(8), PKLR(11), PKM2(5), PNPT1(1), POLA1(2), POLA2(8), POLD1(6), POLD2(2), POLD3(4), POLE(15), POLE2(3), POLR1A(11), POLR1B(8), POLR1C(1), POLR2A(11), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(4), POLR3B(17), POLR3G(1), POLR3GL(1), POLR3H(1), POLR3K(1), PRIM1(3), PRPS1(2), PRPS1L1(13), PRPS2(3), PRUNE(1), RRM1(3), RRM2(2), RRM2B(2), XDH(50)	53915197	956	178	921	495	653	79	48	94	82	0	0.0124	1.000	1.000
94	HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES	Genes involved in complement and coagulation cascades	A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF	64	A2M(22), BDKRB1(5), BDKRB2(9), C1QA(4), C1QB(3), C1QC(7), C1R(13), C1S(15), C3(46), C3AR1(4), C4BPA(16), C4BPB(6), C5(14), C5AR1(9), C6(56), C7(43), C8B(43), C8G(1), C9(19), CD55(4), CD59(1), CFB(32), CFH(43), CFI(13), CPB2(1), CR1(53), CR2(32), F10(8), F11(12), F12(1), F13A1(26), F13B(23), F2(9), F2R(6), F5(30), F7(7), F8(43), F9(12), FGA(38), FGB(10), FGG(7), KLKB1(23), KNG1(11), MASP1(8), MASP2(9), MBL2(12), PLAT(3), PLAU(3), PLAUR(2), PLG(30), PROC(8), PROS1(13), SERPINA1(7), SERPINA5(9), SERPINC1(7), SERPIND1(4), SERPINE1(5), SERPINF2(6), SERPING1(12), TFPI(8), THBD(3), VWF(49)	29185127	978	178	920	422	689	75	42	93	77	2	0.000733	1.000	1.000
95	HSA04910_INSULIN_SIGNALING_PATHWAY	Genes involved in insulin signaling pathway	ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2	129	ACACA(21), ACACB(17), AKT1(3), AKT2(8), AKT3(4), ARAF(4), CALM1(1), CALM2(1), CALML3(6), CBL(8), CBLB(16), CBLC(14), CRK(2), CRKL(2), EIF4EBP1(1), ELK1(2), EXOC7(8), FASN(17), FBP1(2), FBP2(2), FLOT1(2), FOXO1(6), G6PC(5), G6PC2(4), GCK(17), GRB2(2), GSK3B(2), GYS1(3), GYS2(20), HRAS(3), IKBKB(3), INPP5D(31), INSR(20), IRS1(5), IRS2(2), IRS4(12), KRAS(4), LIPE(8), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK10(8), MAPK3(1), MAPK8(1), MAPK9(5), MKNK1(5), MKNK2(2), PCK1(23), PCK2(4), PDE3A(24), PDE3B(6), PDPK1(4), PFKL(4), PFKM(1), PHKA1(19), PHKA2(7), PHKB(7), PHKG1(1), PHKG2(2), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PKLR(11), PKM2(5), PPARGC1A(20), PPP1CA(1), PPP1CB(5), PPP1CC(2), PPP1R3A(55), PPP1R3B(6), PPP1R3C(3), PPP1R3D(3), PRKAA1(1), PRKAA2(24), PRKAB1(2), PRKAB2(2), PRKACA(3), PRKACB(4), PRKACG(8), PRKAG1(2), PRKAG2(7), PRKAG3(10), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCI(8), PRKCZ(5), PRKX(3), PTPN1(4), PTPRF(27), PYGB(2), PYGL(7), PYGM(10), RAF1(8), RAPGEF1(10), RHEB(1), RHOQ(1), RPS6(1), RPS6KB1(2), RPS6KB2(3), SH2B2(4), SHC1(1), SHC2(7), SHC3(11), SHC4(2), SLC2A4(8), SOCS2(2), SOCS3(2), SOCS4(3), SORBS1(13), SOS1(8), SOS2(11), SREBF1(5), TRIP10(4), TSC1(5), TSC2(11)	52717617	885	177	848	407	594	63	37	111	78	2	0.00119	1.000	1.000
96	HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION	Genes involved in Leukocyte transendothelial migration	ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL	109	ACTN1(5), ACTN2(21), ACTN3(7), ACTN4(5), ARHGAP5(11), BCAR1(4), CD99(1), CDC42(2), CDH5(9), CLDN1(5), CLDN10(5), CLDN11(4), CLDN14(5), CLDN16(7), CLDN17(5), CLDN18(7), CLDN19(2), CLDN2(6), CLDN20(1), CLDN22(2), CLDN3(1), CLDN4(10), CLDN6(8), CLDN7(2), CLDN8(3), CLDN9(1), CTNNA1(2), CTNNA2(23), CTNNA3(28), CTNNB1(11), CTNND1(9), CXCL12(2), CXCR4(3), CYBA(1), CYBB(7), ESAM(3), EZR(1), F11R(5), GNAI1(1), GNAI2(5), GNAI3(2), GRLF1(12), ICAM1(2), ITGA4(36), ITGAL(24), ITGAM(21), ITGB1(4), ITGB2(13), ITK(20), JAM2(10), JAM3(2), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MLLT4(13), MMP2(7), MMP9(7), MSN(1), MYL2(5), MYL5(1), MYL7(2), MYL9(2), MYLPF(2), NCF1(1), NCF2(7), NCF4(4), NOX1(11), NOX3(6), OCLN(4), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PLCG1(9), PLCG2(25), PRKCA(10), PRKCG(13), PTK2(8), PTK2B(10), PTPN11(9), PXN(3), RAC2(1), RAP1A(2), RAP1B(1), RAPGEF3(12), RAPGEF4(12), RASSF5(5), RHOA(1), RHOH(5), ROCK1(5), ROCK2(12), SIPA1(8), THY1(1), TXK(9), VASP(3), VAV1(15), VAV2(3), VAV3(9), VCAM1(16), VCL(7)	41100380	767	173	732	381	510	53	25	103	73	3	0.00701	1.000	1.000
97	HSA00500_STARCH_AND_SUCROSE_METABOLISM	Genes involved in starch and sucrose metabolism	AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1	79	AGL(17), AMY2A(5), AMY2B(10), ASCC3(10), ATP13A2(9), DDX18(4), DDX19A(1), DDX23(5), DDX4(11), DDX41(6), DDX47(1), DDX50(4), DDX51(5), DDX52(3), DDX54(2), DDX55(3), DDX56(3), DHX58(4), ENPP1(11), ENPP3(14), ENTPD7(2), EP400(22), ERCC2(2), ERCC3(4), G6PC(5), G6PC2(4), GAA(7), GANC(5), GBA(3), GBA3(14), GBE1(8), GCK(17), GPI(3), GUSB(3), GYS1(3), GYS2(20), HK1(3), HK2(12), HK3(13), IFIH1(13), MGAM(133), MOV10L1(26), NUDT5(2), NUDT8(1), PGM1(4), PGM3(1), PYGB(2), PYGL(7), PYGM(10), RAD54B(6), RUVBL2(4), SETX(17), SI(71), SKIV2L2(4), SMARCA2(11), SMARCA5(5), TREH(3), UGDH(1), UGP2(1), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(8), UGT1A9(10), UGT2A1(18), UGT2A3(24), UGT2B10(36), UGT2B11(19), UGT2B28(24), UGT2B4(31), UGT2B7(17), UXS1(4)	40323132	854	172	798	382	589	71	36	81	76	1	0.00122	1.000	1.000
98	HSA04640_HEMATOPOIETIC_CELL_LINEAGE	Genes involved in hematopoietic cell lineage	ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO	82	ANPEP(17), CD14(5), CD19(7), CD1A(11), CD1B(12), CD1C(23), CD1D(8), CD1E(19), CD22(22), CD33(17), CD34(4), CD36(4), CD37(3), CD38(4), CD3D(5), CD3E(2), CD3G(1), CD4(6), CD44(5), CD5(6), CD55(4), CD59(1), CD8A(2), CD8B(7), CR1(53), CR2(32), CSF1(10), CSF1R(12), CSF2(2), CSF2RA(17), CSF3(4), CSF3R(6), DNTT(9), EPO(5), EPOR(1), FCER2(3), FCGR1A(6), FLT3(31), FLT3LG(2), GP5(4), GP9(6), GYPA(7), HLA-DRA(11), HLA-DRB1(3), HLA-DRB5(1), IL11(2), IL11RA(3), IL1A(4), IL1B(6), IL1R1(11), IL1R2(7), IL2RA(4), IL3(3), IL3RA(7), IL4(1), IL4R(13), IL5(4), IL5RA(12), IL6(2), IL6R(4), IL7(5), IL7R(27), IL9R(5), ITGA1(18), ITGA2(11), ITGA2B(10), ITGA3(7), ITGA4(36), ITGA5(20), ITGA6(8), ITGAM(21), ITGB3(11), KIT(9), KITLG(8), MME(19), MS4A1(7), TFRC(4), THPO(7), TNF(1), TPO(40)	26892554	777	171	735	369	565	42	28	58	84	0	0.00367	1.000	1.000
99	HSA04110_CELL_CYCLE	Genes involved in cell cycle	ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	108	ABL1(12), ANAPC1(16), ANAPC10(1), ANAPC2(4), ANAPC4(4), ANAPC5(6), ANAPC7(6), ATM(12), ATR(20), BUB1(3), BUB1B(9), CCNA1(13), CCNB2(3), CCNB3(28), CCND1(1), CCND2(5), CCND3(2), CCNE1(4), CCNE2(12), CCNH(2), CDC14A(4), CDC14B(1), CDC16(1), CDC20(1), CDC23(3), CDC25A(8), CDC25B(4), CDC25C(4), CDC27(13), CDC6(1), CDC7(2), CDK4(5), CDK6(2), CDKN1A(4), CDKN1B(1), CDKN2C(1), CHEK1(2), CHEK2(3), CREBBP(20), CUL1(5), DBF4(5), E2F1(5), E2F2(4), E2F3(5), EP300(14), ESPL1(14), FZR1(6), GADD45B(2), GSK3B(2), HDAC1(1), HDAC2(1), MAD1L1(5), MAD2L1(1), MAD2L2(1), MCM2(10), MCM3(10), MCM4(5), MCM5(4), MCM6(4), MDM2(3), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), PKMYT1(3), PLK1(3), PRKDC(19), PTTG1(1), PTTG2(5), RB1(8), RBL1(10), RBL2(4), SFN(1), SKP2(2), SMAD2(3), SMAD3(2), SMAD4(2), SMC1A(3), SMC1B(20), TFDP1(2), TGFB1(1), TGFB2(1), TGFB3(3), WEE1(2), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3)	45169962	466	170	450	179	257	40	34	87	46	2	0.0103	1.000	1.000
100	HSA04730_LONG_TERM_DEPRESSION	Genes involved in long-term depression	ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1	72	ARAF(4), C7orf16(1), CACNA1A(32), CRH(3), CRHR1(6), GNA11(7), GNA12(3), GNA13(1), GNAI1(1), GNAI2(5), GNAI3(2), GNAO1(2), GNAQ(4), GNAS(19), GNAZ(6), GRIA1(39), GRIA2(34), GRIA3(23), GRID2(51), GRM1(16), GRM5(13), GUCY1A2(18), GUCY1A3(29), GUCY1B3(7), GUCY2C(32), GUCY2D(8), GUCY2F(15), HRAS(3), IGF1(11), IGF1R(10), ITPR1(29), ITPR2(17), ITPR3(6), KRAS(4), LYN(6), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), NOS1(58), NOS3(16), NPR1(16), NPR2(14), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(6), PRKCA(10), PRKCG(13), PRKG1(12), PRKG2(13), RAF1(8), RYR1(87)	35835626	941	170	869	544	677	63	28	92	80	1	0.0453	1.000	1.000
101	HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450	Genes involved in metabolism of xenobiotics by cytochrome P450	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7	68	ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), AKR1C1(2), AKR1C2(4), AKR1C3(9), AKR1C4(9), ALDH1A3(2), ALDH3A1(5), ALDH3B1(2), ALDH3B2(7), CYP1A1(10), CYP1A2(10), CYP1B1(2), CYP2B6(16), CYP2C18(26), CYP2C19(35), CYP2C8(30), CYP2C9(35), CYP2E1(13), CYP2F1(11), CYP2S1(9), CYP3A4(19), CYP3A43(15), CYP3A5(10), CYP3A7(18), DHDH(5), EPHX1(2), GSTA1(5), GSTA2(2), GSTA3(1), GSTA5(3), GSTK1(2), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTP1(2), GSTT1(1), MGST1(2), MGST2(2), MGST3(1), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(8), UGT1A9(10), UGT2A1(18), UGT2A3(24), UGT2B10(36), UGT2B11(19), UGT2B28(24), UGT2B4(31), UGT2B7(17)	18412491	704	169	641	293	521	49	37	46	50	1	1.76e-09	1.000	1.000
102	HSA04720_LONG_TERM_POTENTIATION	Genes involved in long-term potentiation	ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6	65	ADCY1(26), ADCY8(45), ARAF(4), ATF4(7), CACNA1C(43), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CAMK4(10), CHP(3), CREBBP(20), EP300(14), GNAQ(4), GRIA1(39), GRIA2(34), GRIN1(7), GRIN2A(86), GRIN2B(53), GRIN2C(8), GRIN2D(6), GRM1(16), GRM5(13), HRAS(3), ITPR1(29), ITPR2(17), ITPR3(6), KRAS(4), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PPP1CA(1), PPP1CB(5), PPP1CC(2), PPP1R12A(4), PPP1R1A(4), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PRKACA(3), PRKACB(4), PRKACG(8), PRKCA(10), PRKCG(13), PRKX(3), RAF1(8), RAP1A(2), RAP1B(1), RAPGEF3(12), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KA6(15)	32209252	799	167	744	473	556	64	29	88	61	1	0.260	1.000	1.000
103	HSA02010_ABC_TRANSPORTERS_GENERAL	Genes involved in ABC transporters - general	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	44	ABCA1(11), ABCA10(21), ABCA12(59), ABCA13(60), ABCA2(9), ABCA3(17), ABCA4(49), ABCA5(8), ABCA6(25), ABCA7(11), ABCA8(30), ABCA9(18), ABCB1(35), ABCB10(5), ABCB11(45), ABCB4(17), ABCB5(36), ABCB6(2), ABCB7(6), ABCB8(3), ABCB9(6), ABCC1(12), ABCC10(12), ABCC11(17), ABCC12(23), ABCC2(9), ABCC3(25), ABCC4(11), ABCC5(8), ABCC6(24), ABCC8(37), ABCC9(56), ABCD2(17), ABCD3(9), ABCD4(1), ABCG1(9), ABCG2(6), ABCG4(6), ABCG5(6), ABCG8(15), CFTR(44), TAP1(1), TAP2(13)	39346443	834	165	795	484	561	68	29	91	85	0	0.0301	1.000	1.000
104	HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM	Genes involved in phosphatidylinositol signaling system	CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	72	CALM1(1), CALM2(1), CALML3(6), CDS1(9), CDS2(4), DGKA(3), DGKB(22), DGKD(9), DGKE(6), DGKG(16), DGKH(8), DGKI(23), DGKQ(6), DGKZ(7), IMPA1(1), IMPA2(2), INPP1(2), INPP4A(5), INPP4B(2), INPP5A(4), INPP5B(6), INPP5D(31), INPPL1(15), ITPK1(6), ITPKB(7), ITPR1(29), ITPR2(17), ITPR3(6), OCRL(4), PI4KA(18), PI4KB(4), PIK3C2A(6), PIK3C2B(13), PIK3C2G(43), PIK3C3(3), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PIP4K2A(5), PIP4K2B(3), PIP4K2C(3), PIP5K1A(6), PIP5K1B(18), PIP5K1C(8), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PLCD1(3), PLCD3(3), PLCD4(2), PLCE1(48), PLCG1(9), PLCG2(25), PLCZ1(20), PRKCA(10), PRKCG(13), SYNJ1(20), SYNJ2(15)	41066241	769	165	717	367	536	41	29	94	67	2	0.00138	1.000	1.000
105	INTEGRIN_MEDIATED_CELL_ADHESION_KEGG		AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX	89	AKT1(3), AKT3(4), BCAR1(4), CAPN1(4), CAPN10(7), CAPN11(9), CAPN2(6), CAPN3(9), CAPN5(4), CAPN6(13), CAPN7(1), CAPN9(12), CAPNS1(1), CAV1(1), CDC42(2), CRK(2), CSK(1), DOCK1(15), FYN(6), GIT2(8), GRB2(2), ITGA10(7), ITGA11(16), ITGA2(11), ITGA2B(10), ITGA3(7), ITGA4(36), ITGA5(20), ITGA6(8), ITGA7(23), ITGA8(36), ITGA9(13), ITGAD(24), ITGAE(16), ITGAL(24), ITGAM(21), ITGAV(9), ITGAX(18), ITGB1(4), ITGB2(13), ITGB3(11), ITGB4(20), ITGB5(6), ITGB6(11), ITGB7(6), ITGB8(17), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K6(3), MAPK10(8), MAPK12(1), MAPK4(15), MAPK6(6), MAPK7(4), MYLK2(10), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PDPK1(4), PIK3R2(5), PTK2(8), PXN(3), RAC2(1), RAP1B(1), RAPGEF1(10), RHO(2), ROCK1(5), ROCK2(12), SDCCAG8(3), SEPP1(1), SHC1(1), SHC3(11), SORBS1(13), SOS1(8), SRC(1), TLN1(12), TNS1(9), VASP(3), VAV2(3), VAV3(9), VCL(7), ZYX(6)	44207233	735	164	714	336	497	53	26	94	64	1	0.000673	1.000	1.000
106	HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	Genes involved in Toll-like receptor signaling pathway	AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6	97	AKT1(3), AKT2(8), AKT3(4), CASP8(8), CD14(5), CD40(4), CD80(4), CD86(19), CHUK(2), CXCL10(3), CXCL11(1), CXCL9(2), FOS(2), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(9), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(5), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IKBKB(3), IKBKE(9), IL12A(3), IL12B(3), IL1B(6), IL6(2), IL8(1), IRAK1(4), IRAK4(3), IRF3(3), IRF5(4), IRF7(7), JUN(1), LBP(8), LY96(4), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K6(3), MAP2K7(4), MAP3K7(1), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK8(1), MAPK9(5), MYD88(3), NFKB1(7), NFKB2(4), NFKBIA(2), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), RELA(4), RIPK1(1), SPP1(7), STAT1(4), TBK1(5), TICAM1(9), TIRAP(1), TLR1(10), TLR2(15), TLR3(9), TLR4(31), TLR5(18), TLR6(5), TLR7(15), TLR8(8), TLR9(14), TNF(1), TOLLIP(1), TRAF3(5), TRAF6(4)	29762434	511	163	493	234	324	32	25	81	48	1	0.00642	1.000	1.000
107	HSA04912_GNRH_SIGNALING_PATHWAY	Genes involved in GnRH signaling pathway	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC	94	ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADCY9(9), ATF4(7), CACNA1C(43), CACNA1D(29), CACNA1F(20), CACNA1S(46), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CDC42(2), CGA(1), EGFR(22), ELK1(2), FSHB(4), GNA11(7), GNAQ(4), GNAS(19), GNRH2(2), GNRHR(2), GRB2(2), HBEGF(1), HRAS(3), ITPR1(29), ITPR2(17), ITPR3(6), JUN(1), KRAS(4), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K6(3), MAP2K7(4), MAP3K1(2), MAP3K2(6), MAP3K3(6), MAP3K4(17), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK7(4), MAPK8(1), MAPK9(5), MMP14(2), MMP2(7), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PLD1(11), PLD2(5), PRKACA(3), PRKACB(4), PRKACG(8), PRKCA(10), PRKCD(4), PRKX(3), PTK2B(10), RAF1(8), SOS1(8), SOS2(11), SRC(1)	41918077	803	163	756	517	541	73	36	82	70	1	0.651	1.000	1.000
108	HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	Genes involved in natural killer cell mediated cytotoxicity	ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70	123	ARAF(4), CASP3(2), CD244(8), CD247(3), CD48(4), CHP(3), CSF2(2), FAS(5), FASLG(14), FCER1G(1), FCGR3A(8), FCGR3B(2), FYN(6), GRB2(2), GZMB(3), HLA-A(6), HLA-B(5), HLA-C(1), HLA-E(1), HLA-G(3), HRAS(3), ICAM1(2), ICAM2(4), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(9), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(5), IFNA8(3), IFNAR1(2), IFNAR2(7), IFNB1(6), IFNG(2), IFNGR1(4), IFNGR2(4), ITGAL(24), ITGB2(13), KIR2DL1(21), KIR2DL3(6), KIR2DL4(3), KIR3DL1(17), KIR3DL2(2), KLRC1(4), KLRC2(1), KLRC3(11), KLRD1(5), KLRK1(5), KRAS(4), LAT(1), LCK(12), LCP2(9), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), MICA(3), MICB(3), NCR1(13), NCR2(11), NCR3(3), NFAT5(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PAK1(4), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PLCG1(9), PLCG2(25), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PRF1(11), PRKCA(10), PRKCG(13), PTK2B(10), PTPN11(9), PTPN6(3), RAC2(1), RAF1(8), SH2D1A(2), SH2D1B(3), SH3BP2(2), SHC1(1), SHC2(7), SHC3(11), SHC4(2), SOS1(8), SOS2(11), SYK(14), TNF(1), TNFRSF10A(5), TNFRSF10B(2), TNFRSF10C(4), TNFRSF10D(7), TNFSF10(7), TYROBP(4), ULBP1(2), ULBP3(5), VAV1(15), VAV2(3), VAV3(9), ZAP70(8)	36890420	738	162	707	358	495	51	30	98	63	1	0.0347	1.000	1.000
109	HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1	Genes involved in glycan structures - biosynthesis 1	A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2	107	A4GNT(6), ALG1(2), ALG10(4), ALG10B(4), ALG12(1), ALG13(8), ALG14(2), ALG2(4), ALG3(4), ALG6(2), ALG8(6), ALG9(5), B3GNT1(2), B3GNT2(2), B3GNT7(4), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), B4GALT5(2), C1GALT1(6), C1GALT1C1(2), CHPF(3), CHST1(9), CHST11(5), CHST12(4), CHST13(3), CHST14(3), CHST2(4), CHST3(1), CHST4(9), CHST6(4), CHSY1(8), DAD1(1), DDOST(2), DPAGT1(2), EXT1(2), EXT2(6), EXTL1(2), EXTL3(10), FUT11(3), FUT8(8), GALNT1(4), GALNT10(6), GALNT11(2), GALNT12(8), GALNT13(25), GALNT14(27), GALNT2(6), GALNT3(3), GALNT4(4), GALNT5(9), GALNT6(15), GALNT7(5), GALNT8(23), GALNT9(5), GALNTL1(4), GALNTL2(19), GALNTL4(6), GALNTL5(14), GANAB(5), GCNT1(6), GCNT3(5), GCNT4(4), HS2ST1(1), HS3ST1(10), HS3ST2(7), HS3ST3A1(4), HS3ST3B1(2), HS3ST5(8), HS6ST1(3), HS6ST2(2), HS6ST3(12), MAN1A1(15), MAN1A2(4), MAN1B1(4), MAN1C1(7), MAN2A1(10), MGAT1(3), MGAT2(2), MGAT3(10), MGAT4A(8), MGAT4B(1), MGAT5(4), MGAT5B(9), NDST1(4), NDST2(2), NDST3(23), NDST4(45), OGT(10), RPN2(2), ST3GAL1(6), ST3GAL2(1), ST3GAL3(1), ST3GAL4(1), ST6GAL1(5), ST6GALNAC1(5), STT3B(5), WBSCR17(37), XYLT1(10), XYLT2(3)	36482472	655	161	628	349	444	51	27	70	63	0	0.0812	1.000	1.000
110	HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in T cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70	91	AKT1(3), AKT2(8), AKT3(4), BCL10(3), CARD11(32), CBL(8), CBLB(16), CBLC(14), CD247(3), CD28(1), CD3D(5), CD3E(2), CD3G(1), CD4(6), CD40LG(2), CD8A(2), CD8B(7), CDC42(2), CDK4(5), CHP(3), CHUK(2), CSF2(2), CTLA4(2), FOS(2), FYN(6), GRAP2(4), GRB2(2), HRAS(3), ICOS(3), IFNG(2), IKBKB(3), IL10(3), IL2(4), IL4(1), IL5(4), ITK(20), JUN(1), KRAS(4), LAT(1), LCK(12), LCP2(9), MALT1(7), MAP3K14(3), NCK1(1), NCK2(4), NFAT5(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PDCD1(3), PDK1(2), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PRKCQ(16), PTPN6(3), PTPRC(30), RASGRP1(7), RHOA(1), SOS1(8), SOS2(11), TEC(10), TNF(1), VAV1(15), VAV2(3), VAV3(9), ZAP70(8)	33736670	612	161	587	282	393	46	28	91	53	1	0.0608	1.000	1.000
111	G_PROTEIN_SIGNALING		ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5	90	ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADCY9(9), AKAP1(9), AKAP10(3), AKAP11(12), AKAP12(4), AKAP3(16), AKAP4(16), AKAP6(35), AKAP7(3), AKAP8(6), AKAP9(27), ARHGEF1(1), CALM1(1), CALM2(1), CHMP1B(1), GNA11(7), GNA12(3), GNA13(1), GNA14(5), GNA15(5), GNAI2(5), GNAI3(2), GNAL(2), GNAO1(2), GNAQ(4), GNAZ(6), GNB2(1), GNB3(7), GNB5(2), GNG4(2), GNG7(2), GNGT2(4), HRAS(3), ITPR1(29), KCNJ3(18), KRAS(4), PDE1B(12), PDE1C(41), PDE4A(9), PDE4B(7), PDE4C(16), PDE4D(7), PDE7A(1), PDE7B(16), PDE8A(2), PDE8B(21), PLCB3(4), PPP3CA(5), PPP3CC(2), PRKACA(3), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), PRKCD(4), PRKCE(6), PRKCG(13), PRKCH(10), PRKCI(8), PRKCQ(16), PRKCZ(5), PRKD1(3), PRKD3(4), RHOA(1), RRAS(1), SLC9A1(3), USP5(4)	38488871	631	159	610	393	433	53	31	65	49	0	0.758	1.000	1.000
112	ST_INTEGRIN_SIGNALING_PATHWAY	Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix.	ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX	75	ABL1(12), ACTN1(5), ACTR2(3), ACTR3(2), AKT1(3), AKT2(8), AKT3(4), ANGPTL2(2), ARHGEF6(10), ARHGEF7(3), BCAR1(4), CAV1(1), CDC42(2), CRK(2), CSE1L(5), DOCK1(15), EPHB2(29), FYN(6), GRB2(2), GRB7(5), GRLF1(12), ITGA1(18), ITGA10(7), ITGA11(16), ITGA2(11), ITGA3(7), ITGA4(36), ITGA5(20), ITGA6(8), ITGA7(23), ITGA8(36), ITGA9(13), ITGB3BP(2), MAP2K4(4), MAP2K7(4), MAP3K11(6), MAPK1(4), MAPK10(8), MAPK8(1), MAPK8IP1(4), MAPK8IP2(7), MAPK8IP3(8), MAPK9(5), MRAS(1), MYLK(39), MYLK2(10), P4HB(2), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PIK3CA(8), PIK3CB(21), PKLR(11), PLCG1(9), PLCG2(25), PTK2(8), RAF1(8), RALA(1), RHO(2), ROCK1(5), ROCK2(12), SHC1(1), SOS1(8), SOS2(11), SRC(1), TERF2IP(1), TLN1(12), TLN2(23), VASP(3), WAS(7), ZYX(6)	39667542	694	159	663	318	454	51	26	101	62	0	0.00502	1.000	1.000
113	HSA04916_MELANOGENESIS	Genes involved in melanogenesis	ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B	98	ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADCY9(9), ASIP(2), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CREB3(1), CREB3L1(4), CREB3L2(7), CREB3L3(9), CREB3L4(5), CREBBP(20), CTNNB1(11), DCT(3), DVL2(3), DVL3(7), EDN1(8), EDNRB(4), EP300(14), FZD1(4), FZD10(2), FZD2(5), FZD4(1), FZD5(2), FZD6(2), FZD7(4), FZD8(4), FZD9(1), GNAI1(1), GNAI2(5), GNAI3(2), GNAO1(2), GNAQ(4), GNAS(19), GSK3B(2), HRAS(3), KIT(9), KITLG(8), KRAS(4), LEF1(3), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), MITF(4), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), POMC(3), PRKACA(3), PRKACB(4), PRKACG(8), PRKCA(10), PRKCG(13), PRKX(3), RAF1(8), TCF7(1), TCF7L1(3), TCF7L2(7), TYR(8), TYRP1(8), WNT1(2), WNT10A(7), WNT10B(5), WNT11(4), WNT16(1), WNT2(7), WNT2B(4), WNT3(5), WNT3A(6), WNT4(2), WNT5A(5), WNT5B(5), WNT6(2), WNT7A(13), WNT7B(6), WNT8A(7), WNT8B(7), WNT9A(3), WNT9B(3)	35891068	662	158	623	387	434	57	31	74	65	1	0.236	1.000	1.000
114	HISTONE_METHYLTRANSFERASE	Genes with HMT activity	AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1	55	ASH1L(26), ASH2L(3), CARM1(6), CTCFL(20), DOT1L(8), EED(3), EHMT1(7), EHMT2(9), EZH1(5), EZH2(10), FBXO11(6), HCFC1(15), JMJD4(4), JMJD6(1), KDM6A(3), MEN1(2), MLL(39), MLL2(47), MLL3(61), MLL4(34), MLL5(12), NSD1(16), OGT(10), PAXIP1(3), PPP1CA(1), PPP1CB(5), PPP1CC(2), PRDM2(13), PRDM7(6), PRDM9(47), PRMT1(1), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), RBBP5(5), SATB1(14), SETD1A(23), SETD2(14), SETD7(2), SETD8(1), SETDB1(10), SETDB2(4), SETMAR(4), SMYD3(2), STK38(4), SUV39H1(1), SUV39H2(1), SUV420H1(7), SUV420H2(1), SUZ12(2), WHSC1(9), WHSC1L1(6)	39478641	552	157	534	195	355	56	21	70	50	0	0.00190	1.000	1.000
115	PURINE_METABOLISM		1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC	109	ADA(2), ADCY1(26), ADCY2(8), ADCY3(3), ADCY4(4), ADCY5(15), ADCY6(6), ADCY7(10), ADCY8(45), ADK(4), ADSL(6), ADSS(2), AK1(1), AK2(3), AK5(6), ALLC(7), AMPD1(28), AMPD2(5), AMPD3(22), APRT(3), ATIC(5), ATP1B1(1), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(6), ATP5G2(1), ATP5H(1), ATP5J(2), CANT1(9), DGUOK(4), ENPP1(11), ENPP3(14), ENTPD1(10), ENTPD2(4), FHIT(2), GART(9), GDA(12), GMPS(4), GUCY1A2(18), GUCY1A3(29), GUCY1B3(7), GUCY2C(32), GUCY2D(8), GUCY2F(15), GUK1(2), IMPDH1(2), IMPDH2(1), NPR1(16), NPR2(14), NT5E(4), NT5M(2), PAICS(1), PAPSS1(3), PAPSS2(5), PDE4A(9), PDE4B(7), PDE4C(16), PDE4D(7), PDE5A(8), PDE6B(13), PDE6C(23), PDE6G(2), PDE7B(16), PDE8A(2), PDE9A(9), PFAS(8), PKLR(11), PKM2(5), POLD1(6), POLD2(2), POLE(15), POLG(8), POLL(7), POLQ(23), POLR1B(8), POLR2A(11), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(2), PRPS1(2), PRPS1L1(13), PRPS2(3), PRUNE(1), RRM1(3), RRM2(2)	42318372	727	157	694	383	502	61	26	69	69	0	0.0197	1.000	1.000
116	HSA04012_ERBB_SIGNALING_PATHWAY	Genes involved in ErbB signaling pathway	ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA	83	ABL1(12), ABL2(10), AKT1(3), AKT2(8), AKT3(4), ARAF(4), AREG(7), BTC(2), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CBL(8), CBLB(16), CBLC(14), CDKN1A(4), CDKN1B(1), CRK(2), CRKL(2), EGF(18), EGFR(22), EIF4EBP1(1), ELK1(2), ERBB2(7), ERBB3(5), ERBB4(47), EREG(4), GAB1(4), GRB2(2), GSK3B(2), HBEGF(1), HRAS(3), JUN(1), KRAS(4), MAP2K1(10), MAP2K2(3), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK3(1), MAPK8(1), MAPK9(5), MYC(5), NCK1(1), NCK2(4), NRG1(14), NRG2(7), NRG3(20), NRG4(1), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PLCG1(9), PLCG2(25), PRKCA(10), PRKCG(13), PTK2(8), RAF1(8), RPS6KB1(2), RPS6KB2(3), SHC1(1), SHC2(7), SHC3(11), SHC4(2), SOS1(8), SOS2(11), SRC(1), STAT5A(2), STAT5B(4), TGFA(2)	33615281	616	156	582	274	400	43	29	91	52	1	0.0205	1.000	1.000
117	HSA04520_ADHERENS_JUNCTION	Genes involved in adherens junction	ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1	74	ACP1(3), ACTB(7), ACTG1(5), ACTN1(5), ACTN2(21), ACTN3(7), ACTN4(5), ACVR1B(3), ACVR1C(9), BAIAP2(5), CDC42(2), CDH1(5), CREBBP(20), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(23), CTNNA3(28), CTNNB1(11), CTNND1(9), EGFR(22), EP300(14), ERBB2(7), FARP2(5), FER(3), FGFR1(11), FYN(6), IGF1R(10), INSR(20), IQGAP1(10), LEF1(3), LMO7(26), MAP3K7(1), MAPK1(4), MAPK3(1), MET(19), MLLT4(13), NLK(5), PARD3(15), PTPN1(4), PTPN6(3), PTPRB(79), PTPRF(27), PTPRJ(8), PTPRM(7), PVRL1(4), PVRL2(5), PVRL3(5), PVRL4(7), RAC2(1), RHOA(1), SMAD2(3), SMAD3(2), SMAD4(2), SNAI1(2), SNAI2(4), SORBS1(13), SRC(1), SSX2IP(5), TCF7(1), TCF7L1(3), TCF7L2(7), TGFBR2(8), TJP1(11), VCL(7), WAS(7), WASF1(4), WASF2(4), WASF3(12), WASL(5), YES1(5)	40028787	625	156	598	308	417	46	25	68	66	3	0.205	1.000	1.000
118	STARCH_AND_SUCROSE_METABOLISM		AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1	40	AGL(17), AMY2A(5), AMY2B(10), ENPP1(11), ENPP3(14), G6PC(5), GAA(7), GANAB(5), GBA3(14), GBE1(8), GCK(17), GPI(3), GUSB(3), GYS1(3), GYS2(20), HK1(3), HK2(12), HK3(13), MGAM(133), PGM1(4), PGM3(1), PYGB(2), PYGL(7), PYGM(10), SI(71), UCHL1(4), UCHL3(2), UGDH(1), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(8), UGT1A9(10), UGT2B4(31), UXS1(4)	18245998	521	156	483	224	367	54	22	42	35	1	0.000537	1.000	1.000
119	PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM		ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1	82	ACVR1(2), ACVR1B(3), ACVRL1(9), AKT1(3), AURKB(2), BMPR1A(2), BMPR2(5), BUB1(3), CDKL1(5), CDKL2(2), CDS1(9), CDS2(4), CLK1(4), CLK2(6), COL4A3BP(3), CSNK2A1(1), CSNK2A2(1), CSNK2B(1), DGKA(3), DGKB(22), DGKD(9), DGKE(6), DGKG(16), DGKH(8), DGKQ(6), DGKZ(7), IMPA1(1), INPP1(2), INPP4A(5), INPP4B(2), INPP5A(4), INPPL1(15), ITPKB(7), MAP3K10(8), MOS(5), NEK1(8), NEK3(2), OCRL(4), PAK4(4), PIK3C2A(6), PIK3C2B(13), PIK3C2G(43), PIK3CA(8), PIK3CB(21), PIK3CG(24), PIM2(4), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PLCD1(3), PLCG1(9), PLCG2(25), PLK3(2), PRKACA(3), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), PRKCD(4), PRKCE(6), PRKCG(13), PRKCH(10), PRKCQ(16), PRKCZ(5), PRKD1(3), PRKG1(12), RAF1(8), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KA4(4), RPS6KB1(2), STK11(3)	37505174	633	155	595	346	434	33	24	78	63	1	0.598	1.000	1.000
120	PEPTIDE_GPCRS		AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR	66	AGTR1(10), AGTR2(9), ATP8A1(22), AVPR1A(4), AVPR1B(9), AVPR2(1), BDKRB1(5), BDKRB2(9), BRS3(5), C3AR1(4), CCKAR(9), CCKBR(10), CCR1(9), CCR10(2), CCR2(16), CCR3(10), CCR4(7), CCR5(7), CCR6(2), CCR7(3), CCR8(6), CX3CR1(13), CXCR3(4), CXCR4(3), CXCR6(4), EDNRA(8), EDNRB(4), FPR1(18), FSHR(15), GALR1(5), GALR3(2), GALT(2), GHSR(8), GNB2L1(3), GNRHR(2), GPR77(5), GRPR(5), LHCGR(24), MC2R(5), MC3R(7), MC4R(1), MC5R(7), NMBR(6), NPY1R(25), NPY2R(12), NPY5R(22), NTSR1(6), NTSR2(3), OPRD1(2), OPRK1(21), OPRL1(5), OPRM1(5), OXTR(5), PPYR1(12), SSTR1(10), SSTR2(5), SSTR3(11), SSTR4(3), TACR1(7), TACR2(7), TACR3(25), TRHR(19), TSHR(8)	17484509	523	154	497	348	365	46	20	55	37	0	0.000644	1.000	1.000
121	CELL_CYCLE_KEGG		ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1	80	ABL1(12), ATM(12), BUB1(3), BUB1B(9), CCNA1(13), CCNB2(3), CCNB3(28), CCND2(5), CCND3(2), CCNE1(4), CCNE2(12), CCNH(2), CDAN1(5), CDC14A(4), CDC14B(1), CDC20(1), CDC25A(8), CDC25B(4), CDC25C(4), CDC6(1), CDC7(2), CDH1(5), CDK4(5), CDKN1A(4), CHEK1(2), CHEK2(3), DTX4(4), E2F1(5), E2F2(4), E2F3(5), E2F4(1), E2F5(1), EP300(14), ESPL1(14), GSK3B(2), HDAC1(1), HDAC2(1), HDAC3(5), HDAC4(10), HDAC5(6), HDAC6(2), HDAC8(3), MAD1L1(5), MAD2L1(1), MAD2L2(1), MCM2(10), MCM3(10), MCM4(5), MCM5(4), MCM6(4), MDM2(3), MPEG1(6), MPL(7), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), PLK1(3), PRKDC(19), PTPRA(7), PTTG1(1), PTTG2(5), RB1(8), RBL1(10), SKP2(2), SMAD4(2), TBC1D8(8), TFDP1(2), TGFB1(1), WEE1(2)	36212931	373	152	364	158	220	37	19	64	31	2	0.0294	1.000	1.000
122	HSA04350_TGF_BETA_SIGNALING_PATHWAY	Genes involved in TGF-beta signaling pathway	ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9	88	ACVR1(2), ACVR1B(3), ACVR1C(9), ACVR2A(3), ACVR2B(3), ACVRL1(9), AMHR2(15), BMP2(4), BMP4(3), BMP5(25), BMP6(10), BMP7(2), BMP8A(2), BMP8B(1), BMPR1A(2), BMPR1B(3), BMPR2(5), CHRD(14), COMP(7), CREBBP(20), CUL1(5), DCN(17), E2F4(1), E2F5(1), EP300(14), FST(4), GDF5(13), GDF6(2), GDF7(2), ID2(2), IFNG(2), INHBA(16), INHBB(7), INHBC(11), INHBE(3), LEFTY1(7), LEFTY2(3), LTBP1(43), MAPK1(4), MAPK3(1), MYC(5), NODAL(2), NOG(1), PITX2(4), PPP2CA(1), PPP2CB(2), PPP2R1A(2), PPP2R1B(4), PPP2R2A(2), PPP2R2B(5), PPP2R2C(6), RBL1(10), RBL2(4), RHOA(1), ROCK1(5), ROCK2(12), RPS6KB1(2), RPS6KB2(3), SMAD1(5), SMAD2(3), SMAD3(2), SMAD4(2), SMAD5(3), SMAD6(7), SMAD7(2), SMAD9(10), SMURF1(1), SMURF2(9), SP1(5), TFDP1(2), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(8), THBS1(27), THBS2(9), THBS3(10), THBS4(11), TNF(1), ZFYVE16(4), ZFYVE9(8)	33158853	505	152	489	248	333	44	19	58	51	0	0.352	1.000	1.000
123	HSA00561_GLYCEROLIPID_METABOLISM	Genes involved in glycerolipid metabolism	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2	55	ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), AGK(6), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPAT6(2), AKR1A1(3), AKR1B1(2), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), CEL(11), DAK(3), DGAT1(1), DGAT2(6), DGKA(3), DGKB(22), DGKD(9), DGKE(6), DGKG(16), DGKH(8), DGKI(23), DGKQ(6), DGKZ(7), GK(6), GK2(35), GLA(1), GLB1(8), GPAM(5), LCT(40), LIPA(4), LIPC(8), LIPF(15), LIPG(6), LPL(3), MGLL(6), PNLIP(7), PNLIPRP1(10), PNLIPRP2(2), PNPLA3(2), PPAP2B(6), PPAP2C(8)	19674345	467	150	426	202	320	43	17	54	33	0	0.000171	1.000	1.000
124	INTRINSICPATHWAY	The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1	22	COL4A1(57), COL4A2(30), COL4A3(37), COL4A4(91), COL4A5(53), COL4A6(32), F10(8), F11(12), F12(1), F2(9), F2R(6), F5(30), F8(43), F9(12), FGA(38), FGB(10), FGG(7), KLKB1(23), PROC(8), PROS1(13), SERPINC1(7), SERPING1(12)	14839385	539	150	509	166	412	37	20	44	26	0	0.0537	1.000	1.000
125	HSA04320_DORSO_VENTRAL_AXIS_FORMATION	Genes involved in dorso-ventral axis formation	BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2	27	CPEB1(8), EGFR(22), ERBB2(7), ERBB4(47), ETS1(4), ETS2(8), ETV6(11), ETV7(3), FMN2(72), GRB2(2), KRAS(4), MAP2K1(10), MAPK1(4), MAPK3(1), NOTCH1(6), NOTCH2(41), NOTCH3(23), NOTCH4(54), PIWIL1(20), PIWIL2(11), PIWIL3(13), PIWIL4(4), RAF1(8), SOS1(8), SOS2(11), SPIRE1(2), SPIRE2(6)	17033669	410	149	388	170	277	23	13	64	33	0	0.0629	1.000	1.000
126	HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY	Genes involved in Fc epsilon RI signaling pathway	AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3	72	AKT1(3), AKT2(8), AKT3(4), BTK(15), CSF2(2), FCER1A(12), FCER1G(1), FYN(6), GAB2(4), GRB2(2), HRAS(3), IL13(2), IL3(3), IL4(1), IL5(4), INPP5D(31), KRAS(4), LAT(1), LCP2(9), LYN(6), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K6(3), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK8(1), MAPK9(5), MS4A2(10), PDK1(2), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PLCG1(9), PLCG2(25), PRKCA(10), PRKCD(4), PRKCE(6), RAC2(1), RAF1(8), SOS1(8), SOS2(11), SYK(14), TNF(1), VAV1(15), VAV2(3), VAV3(9)	23827398	458	148	437	194	290	29	19	71	48	1	0.00243	1.000	1.000
127	MRNA_PROCESSING_REACTOME		BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2	92	CD2BP2(2), CDC40(4), CLK2(6), CLK3(2), COL2A1(29), CPSF1(6), CPSF2(2), CPSF3(4), CSTF1(5), CSTF2(4), CSTF2T(3), CSTF3(5), DDIT3(2), DDX1(2), DDX20(8), DHX15(4), DHX16(8), DHX38(9), DHX8(11), DHX9(10), DICER1(17), DNAJC8(2), GIPC1(4), LOC440563(21), LSM2(2), LSM7(1), METTL3(2), NCBP1(1), NONO(8), NUDT21(3), NXF1(4), PABPN1(1), PAPOLA(4), PHF5A(1), POLR2A(11), PPM1G(2), PRPF18(4), PRPF3(4), PRPF4(3), PRPF4B(5), PRPF8(12), PSKH1(2), PTBP1(1), PTBP2(7), RBM17(1), RBM5(8), RNGTT(1), RNMT(8), RNPS1(1), SF3A1(7), SF3A2(5), SF3A3(4), SF3B1(14), SF3B2(9), SF3B4(5), SF4(8), SFRS12(2), SFRS14(13), SFRS16(5), SFRS4(2), SFRS5(3), SFRS6(2), SFRS7(2), SFRS8(7), SFRS9(2), SNRPA(2), SNRPA1(1), SNRPB(5), SNRPB2(1), SNRPD1(1), SNRPE(2), SNRPN(5), SNURF(2), SPOP(2), SRPK1(8), SRPK2(2), SRRM1(7), SUPT5H(7), TXNL4A(1), U2AF2(3), XRN2(5)	35579573	411	148	403	179	246	37	22	57	49	0	0.467	1.000	1.000
128	TRYPTOPHAN_METABOLISM		AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2	54	AANAT(1), ABP1(18), ACAT2(1), ACMSD(10), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2), AOC2(7), AOC3(8), AOX1(21), ASMT(6), CAT(5), CYP19A1(10), CYP1A1(10), CYP1A2(10), CYP2A13(11), CYP2A6(11), CYP2A7(8), CYP2B6(16), CYP2C18(26), CYP2C19(35), CYP2C8(30), CYP2C9(35), CYP2D6(1), CYP2E1(13), CYP2F1(11), CYP2J2(5), CYP3A4(19), CYP3A5(10), CYP3A7(18), CYP4B1(20), CYP4F8(15), CYP51A1(1), DDC(12), ECHS1(2), EHHADH(6), GCDH(5), HAAO(3), HADHA(8), KMO(8), KYNU(11), MAOA(3), MAOB(13), SDS(2), TDO2(5), TPH1(5), WARS(4), WARS2(4)	18324675	521	148	492	295	394	34	21	38	34	0	0.0497	1.000	1.000
129	HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM	Genes involved in androgen and estrogen metabolism	AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22	53	AKR1C4(9), AKR1D1(17), ARSD(3), ARSE(5), CARM1(6), CYP11B1(13), CYP11B2(13), CYP19A1(10), HEMK1(4), HSD11B1(11), HSD11B2(2), HSD17B12(2), HSD17B2(9), HSD17B3(5), HSD17B7(1), HSD3B1(10), HSD3B2(10), LCMT1(4), METTL2B(7), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), SRD5A1(2), SRD5A2(6), STS(7), SULT1E1(12), SULT2A1(7), SULT2B1(6), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(8), UGT1A9(10), UGT2A1(18), UGT2A3(24), UGT2B10(36), UGT2B11(19), UGT2B28(24), UGT2B4(31), UGT2B7(17), WBSCR22(1)	15968958	458	147	425	189	319	43	23	31	41	1	6.57e-06	1.000	1.000
130	CALCINEURIN_NF_AT_SIGNALING	Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT.	ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5	92	ACTB(7), BCL2(2), CABIN1(9), CALM1(1), CALM2(1), CAMK2B(4), CAMK4(10), CD3E(2), CD3G(1), CD69(4), CDKN1A(4), CNR1(9), CREBBP(20), CSF2(2), CSNK2A1(1), CSNK2B(1), CTLA4(2), EGR2(4), EGR3(2), EP300(14), FCER1A(12), FCGR3A(8), FOS(2), GATA3(8), GATA4(2), GRLF1(12), GSK3B(2), HRAS(3), ICOS(3), IFNA1(1), IFNB1(6), IFNG(2), IL10(3), IL13(2), IL1B(6), IL2(4), IL2RA(4), IL3(3), IL4(1), IL6(2), IL8(1), ITK(20), KPNA5(1), MAP2K7(4), MAPK14(5), MAPK8(1), MAPK9(5), MEF2A(5), MEF2B(2), MEF2D(4), MYF5(13), NCK2(4), NFAT5(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB2(4), NFKBIB(1), NPPB(5), NUP214(12), OPRD1(2), P2RX7(5), PAK1(4), PIN1(1), PPIA(1), PPP3CB(4), PPP3CC(2), PPP3R1(1), PTPRC(30), RELA(4), RPL13A(2), SFN(1), SLA(2), SP1(5), SP3(1), TGFB1(1), TNF(1), TRAF2(2), TRPV6(29), VAV1(15), VAV2(3), VAV3(9), XPO5(7)	30429423	458	145	441	228	307	30	21	49	51	0	0.181	1.000	1.000
131	GPCRDB_OTHER		ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1	52	ADORA3(12), ALG6(2), CCKBR(10), CCR2(16), CCR3(10), CCR5(7), CELSR1(25), CELSR2(23), CELSR3(31), CHRM2(18), CHRM3(19), CXCR3(4), DRD4(1), EDNRA(8), EMR2(4), EMR3(18), F2R(6), FSHR(15), GHRHR(4), GNRHR(2), GPR116(33), GPR132(3), GPR133(13), GPR143(3), GPR17(1), GPR18(5), GPR55(4), GPR56(4), GPR61(8), GPR77(5), GPR84(8), GRM1(16), GRPR(5), HRH4(5), LGR6(17), LPHN2(34), LPHN3(20), LTB4R2(1), NTSR1(6), OR2M4(12), OR8G2(16), P2RY13(4), PTGFR(20), SMO(10), SSTR2(5), TAAR5(3), TSHR(8)	22218291	504	145	484	324	333	43	21	66	40	1	0.150	1.000	1.000
132	HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY	Genes involved in B cell receptor signaling pathway	AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3	60	AKT1(3), AKT2(8), AKT3(4), BCL10(3), BLNK(12), BTK(15), CARD11(32), CD19(7), CD22(22), CD72(4), CD79A(2), CD79B(1), CD81(2), CHP(3), CHUK(2), CR2(32), FCGR2B(3), FOS(2), GSK3B(2), HRAS(3), IKBKB(3), INPP5D(31), JUN(1), KRAS(4), LILRB3(6), LYN(6), MALT1(7), NFAT5(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PLCG2(25), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PTPN6(3), RAC2(1), RASGRP3(13), SYK(14), VAV1(15), VAV2(3), VAV3(9)	24618622	471	145	457	197	299	28	26	67	50	1	0.00129	1.000	1.000
133	HSA03320_PPAR_SIGNALING_PATHWAY	Genes involved in PPAR signaling pathway	ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1	67	ACAA1(5), ACADL(4), ACADM(5), ACOX1(7), ACOX2(7), ACOX3(11), ACSL1(4), ACSL3(6), ACSL4(2), ACSL5(20), ACSL6(13), ADIPOQ(3), ANGPTL4(4), APOA1(2), APOA5(6), AQP7(3), CD36(4), CPT1A(10), CPT1B(10), CPT1C(13), CPT2(1), CYP27A1(4), CYP4A11(23), CYP4A22(19), CYP7A1(8), CYP8B1(12), DBI(1), EHHADH(6), FABP1(6), FABP2(6), FABP3(1), FABP4(1), FADS2(3), GK(6), GK2(35), HMGCS2(17), LPL(3), ME1(19), MMP1(11), NR1H3(3), OLR1(5), PCK1(23), PCK2(4), PDPK1(4), PLTP(1), PPARA(6), PPARD(3), PPARG(11), RXRA(4), RXRB(4), RXRG(5), SCD(3), SCP2(2), SLC27A1(3), SLC27A2(12), SLC27A4(4), SLC27A5(6), SLC27A6(27), SORBS1(13), UBC(6), UCP1(4)	21943687	474	144	451	247	339	38	17	40	39	1	0.0637	1.000	1.000
134	HSA00562_INOSITOL_PHOSPHATE_METABOLISM	Genes involved in inositol phosphate metabolism	CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2	46	IMPA1(1), IMPA2(2), INPP1(2), INPP4A(5), INPP4B(2), INPP5A(4), INPP5B(6), INPPL1(15), IPMK(2), ISYNA1(1), ITPK1(6), ITPKB(7), MINPP1(1), MIOX(3), OCRL(4), PI4KA(18), PI4KB(4), PIK3C3(3), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIP4K2A(5), PIP4K2B(3), PIP4K2C(3), PIP5K1A(6), PIP5K1B(18), PIP5K1C(8), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PLCD1(3), PLCD3(3), PLCD4(2), PLCE1(48), PLCG1(9), PLCG2(25), PLCZ1(20), SYNJ1(20), SYNJ2(15)	24382698	464	143	436	210	314	24	21	67	37	1	0.00381	1.000	1.000
135	HSA04210_APOPTOSIS	Genes involved in apoptosis	AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2	79	AIFM1(1), AKT1(3), AKT2(8), AKT3(4), APAF1(6), ATM(12), BAX(3), BCL2(2), BIRC2(5), BIRC3(7), CAPN1(4), CAPN2(6), CASP10(4), CASP3(2), CASP7(4), CASP8(8), CASP9(3), CFLAR(4), CHP(3), CHUK(2), CSF2RB(17), CYCS(1), DFFA(2), DFFB(3), FAS(5), FASLG(14), IKBKB(3), IL1A(4), IL1B(6), IL1R1(11), IL1RAP(4), IL3(3), IL3RA(7), IRAK1(4), IRAK2(14), IRAK3(7), IRAK4(3), MAP3K14(3), MYD88(3), NFKB1(7), NFKB2(4), NFKBIA(2), NTRK1(15), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PRKACA(3), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RELA(4), RIPK1(1), TNF(1), TNFRSF10A(5), TNFRSF10B(2), TNFRSF10C(4), TNFRSF10D(7), TNFRSF1A(3), TNFSF10(7), TRAF2(2)	27498632	395	143	386	207	242	27	18	67	40	1	0.571	1.000	1.000
136	STRIATED_MUSCLE_CONTRACTION		ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM	36	ACTA1(4), ACTA2(4), ACTN2(21), ACTN3(7), ACTN4(5), DES(8), DMD(31), FAM48A(1), MYBPC1(19), MYBPC2(17), MYBPC3(15), MYH3(21), MYH6(32), MYH7(43), MYH8(52), MYL1(12), MYL2(5), MYL3(2), MYL4(5), MYL9(2), MYOM1(23), NEB(107), TCAP(1), TNNC2(3), TNNI1(1), TNNI2(2), TNNI3(2), TNNT1(3), TNNT2(4), TNNT3(3), TPM1(3), TPM2(3), TPM3(2), TPM4(2), VIM(5)	20927675	470	141	451	283	321	37	18	43	49	2	0.0343	1.000	1.000
137	HSA04370_VEGF_SIGNALING_PATHWAY	Genes involved in VEGF signaling pathway	AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA	67	AKT1(3), AKT2(8), AKT3(4), CASP9(3), CDC42(2), CHP(3), HRAS(3), KDR(42), KRAS(4), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPKAPK2(7), MAPKAPK3(3), NFAT5(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NOS3(16), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PLCG1(9), PLCG2(25), PPP3CA(5), PPP3CB(4), PPP3CC(2), PPP3R1(1), PPP3R2(6), PRKCA(10), PRKCG(13), PTGS2(10), PTK2(8), PXN(3), RAC2(1), RAF1(8), SH2D2A(3), SHC2(7), SPHK1(1), SPHK2(7), SRC(1), VEGFA(5)	23797486	449	139	429	198	289	23	14	74	48	1	0.00840	1.000	1.000
138	G1_TO_S_CELL_CYCLE_REACTOME		ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1	63	ATM(12), CCNA1(13), CCND1(1), CCND2(5), CCND3(2), CCNE1(4), CCNE2(12), CCNH(2), CDC25A(8), CDK4(5), CDKN1A(4), CDKN1B(1), CDKN2C(1), CREB3(1), CREB3L1(4), CREB3L3(9), CREB3L4(5), E2F1(5), E2F2(4), E2F3(5), E2F4(1), E2F5(1), GBA2(2), MCM2(10), MCM3(10), MCM4(5), MCM5(4), MCM6(4), MDM2(3), MNAT1(2), MYC(5), MYT1(21), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), POLA2(8), POLE(15), POLE2(3), PRIM1(3), RB1(8), RBL1(10), RPA1(3), RPA2(2), RPA3(1), TFDP1(2), TFDP2(4), TNXB(132), WEE1(2)	25955051	379	138	362	161	231	27	12	69	38	2	0.0319	1.000	1.000
139	HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1	64	ACSS1(1), ACSS2(4), ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), AKR1A1(3), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH7A1(9), ALDH9A1(2), ALDOA(2), ALDOB(12), ALDOC(3), BPGM(2), DLAT(2), DLD(2), ENO1(4), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(5), G6PC2(4), GALM(2), GAPDH(1), GAPDHS(1), GCK(17), GPI(3), HK1(3), HK2(12), HK3(13), LDHA(5), LDHAL6A(4), LDHAL6B(7), LDHB(2), LDHC(5), PDHA1(3), PDHA2(17), PDHB(1), PFKL(4), PFKM(1), PGAM2(3), PGK1(4), PGK2(27), PGM1(4), PGM3(1), PKLR(11), PKM2(5)	19458510	364	138	329	165	254	31	18	38	23	0	0.000275	1.000	1.000
140	HSA00350_TYROSINE_METABOLISM	Genes involved in tyrosine metabolism	ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22	56	ABP1(18), ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), ALDH1A3(2), ALDH3A1(5), ALDH3B1(2), ALDH3B2(7), AOC2(7), AOC3(8), AOX1(21), CARM1(6), COMT(3), DBH(13), DCT(3), DDC(12), ECH1(1), ESCO1(1), ESCO2(2), FAH(4), GOT1(6), GOT2(5), HEMK1(4), HGD(12), HPD(5), LCMT1(4), MAOA(3), MAOB(13), METTL2B(7), METTL6(2), MYST3(15), MYST4(14), NAT6(2), PNMT(4), PNPLA3(2), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), SH3GLB1(2), TAT(17), TH(9), TPO(40), TYR(8), TYRP1(8), WBSCR22(1)	19850042	433	136	407	215	313	37	22	39	22	0	0.0387	1.000	1.000
141	HSA04742_TASTE_TRANSDUCTION	Genes involved in taste transduction	ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5	47	ACCN1(11), ADCY4(4), ADCY6(6), ADCY8(45), CACNA1A(32), CACNA1B(26), GNAS(19), GNAT3(3), GNB3(7), GRM4(19), ITPR3(6), KCNB1(31), PLCB2(9), PRKACA(3), PRKACB(4), PRKACG(8), PRKX(3), SCNN1A(7), SCNN1B(13), SCNN1G(26), TAS1R1(10), TAS1R2(23), TAS1R3(2), TAS2R1(8), TAS2R10(7), TAS2R13(2), TAS2R14(2), TAS2R16(8), TAS2R3(1), TAS2R38(14), TAS2R39(10), TAS2R4(3), TAS2R40(4), TAS2R41(12), TAS2R42(2), TAS2R43(1), TAS2R46(2), TAS2R5(3), TAS2R50(1), TAS2R60(16), TAS2R7(3), TAS2R8(4), TAS2R9(6), TRPM5(13)	18515639	439	136	417	382	297	34	19	49	40	0	0.984	1.000	1.000
142	ST_G_ALPHA_I_PATHWAY	Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits.	AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP	33	AKT1(3), AKT2(8), AKT3(4), DAG1(5), DRD2(15), EGFR(22), EPHB2(29), GRB2(2), ITPKB(7), ITPR1(29), ITPR2(17), ITPR3(6), KCNJ3(18), KCNJ5(12), KCNJ9(4), MAPK1(4), PI3(6), PIK3CB(21), PITX2(4), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), RAF1(8), RGS20(2), SHC1(1), SOS1(8), SOS2(11), SRC(1), STAT3(10), TERF2IP(1)	19034404	388	136	360	200	253	31	22	48	33	1	0.0855	1.000	1.000
143	ACE2PATHWAY	Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7.	ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN	12	ACE2(7), AGT(5), AGTR1(10), AGTR2(9), CMA1(5), COL4A1(57), COL4A2(30), COL4A3(37), COL4A4(91), COL4A5(53), COL4A6(32), REN(9)	8428727	345	134	324	102	282	17	8	23	15	0	0.490	1.000	1.000
144	HSA00071_FATTY_ACID_METABOLISM	Genes involved in fatty acid metabolism	ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI	47	ACAA1(5), ACAA2(1), ACADL(4), ACADM(5), ACADS(4), ACADSB(6), ACADVL(1), ACAT2(1), ACOX1(7), ACOX3(11), ACSL1(4), ACSL3(6), ACSL4(2), ACSL5(20), ACSL6(13), ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), CPT1A(10), CPT1B(10), CPT1C(13), CPT2(1), CYP4A11(23), CYP4A22(19), DCI(2), ECHS1(2), EHHADH(6), GCDH(5), HADHA(8), HADHB(4), HSD17B10(2), HSD17B4(6), PECI(2)	16451812	346	134	319	150	247	29	18	27	24	1	0.00271	1.000	1.000
145	HSA04330_NOTCH_SIGNALING_PATHWAY	Genes involved in Notch signaling pathway	ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1	43	ADAM17(1), APH1A(2), CREBBP(20), CTBP2(1), DLL1(2), DLL3(6), DLL4(6), DTX1(8), DTX2(3), DTX3(4), DTX3L(6), DTX4(4), DVL2(3), DVL3(7), EP300(14), HDAC1(1), HDAC2(1), HES1(2), JAG1(8), JAG2(7), LFNG(3), MAML1(4), MAML2(6), MAML3(7), MFNG(7), NCOR2(24), NCSTN(4), NOTCH1(6), NOTCH2(41), NOTCH3(23), NOTCH4(54), NUMB(4), NUMBL(4), PSEN1(1), PSEN2(2), PTCRA(3), RBPJ(4), RBPJL(3), SNW1(2)	22959459	308	134	301	161	180	29	11	60	28	0	0.775	1.000	1.000
146	HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC	Genes involved in pathogenic Escherichia coli infection - EHEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(12), ACTB(7), ACTG1(5), ARHGEF2(17), ARPC5(1), CD14(5), CDC42(2), CDH1(5), CLDN1(5), CTNNB1(11), CTTN(2), EZR(1), FYN(6), HCLS1(9), ITGB1(4), KRT18(3), LY96(4), NCK1(1), NCK2(4), NCL(6), OCLN(4), PRKCA(10), RHOA(1), ROCK1(5), ROCK2(12), TLR4(31), TLR5(18), TUBA1A(2), TUBA1B(4), TUBA1C(2), TUBA3C(21), TUBA3D(11), TUBA3E(3), TUBA4A(6), TUBA8(3), TUBAL3(11), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(5), TUBB4(3), TUBB4Q(9), TUBB6(10), TUBB8(13), WAS(7), WASL(5), YWHAQ(3)	17522016	316	134	303	129	206	32	11	35	32	0	0.000576	1.000	1.000
147	HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC	Genes involved in pathogenic Escherichia coli infection - EPEC	ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ	51	ABL1(12), ACTB(7), ACTG1(5), ARHGEF2(17), ARPC5(1), CD14(5), CDC42(2), CDH1(5), CLDN1(5), CTNNB1(11), CTTN(2), EZR(1), FYN(6), HCLS1(9), ITGB1(4), KRT18(3), LY96(4), NCK1(1), NCK2(4), NCL(6), OCLN(4), PRKCA(10), RHOA(1), ROCK1(5), ROCK2(12), TLR4(31), TLR5(18), TUBA1A(2), TUBA1B(4), TUBA1C(2), TUBA3C(21), TUBA3D(11), TUBA3E(3), TUBA4A(6), TUBA8(3), TUBAL3(11), TUBB(1), TUBB1(4), TUBB2A(2), TUBB3(5), TUBB4(3), TUBB4Q(9), TUBB6(10), TUBB8(13), WAS(7), WASL(5), YWHAQ(3)	17522016	316	134	303	129	206	32	11	35	32	0	0.000576	1.000	1.000
148	MAPKPATHWAY	The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5.	ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	82	ATF2(5), CHUK(2), DAXX(9), ELK1(2), FOS(2), GRB2(2), HRAS(3), IKBKB(3), JUN(1), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP2K5(3), MAP2K6(3), MAP2K7(4), MAP3K1(2), MAP3K10(8), MAP3K11(6), MAP3K12(3), MAP3K13(10), MAP3K14(3), MAP3K2(6), MAP3K3(6), MAP3K4(17), MAP3K5(16), MAP3K6(6), MAP3K7(1), MAP3K9(22), MAP4K1(9), MAP4K2(6), MAP4K3(8), MAP4K4(7), MAP4K5(3), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK4(15), MAPK6(6), MAPK7(4), MAPK8(1), MAPK9(5), MAPKAPK2(7), MAPKAPK3(3), MAPKAPK5(1), MEF2A(5), MEF2B(2), MEF2C(2), MEF2D(4), MKNK1(5), MKNK2(2), MYC(5), NFKB1(7), NFKBIA(2), PAK1(4), PAK2(8), RAF1(8), RELA(4), RIPK1(1), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KA4(4), RPS6KA5(4), RPS6KB1(2), RPS6KB2(3), SHC1(1), SP1(5), STAT1(4), TGFB1(1), TGFB2(1), TGFB3(3), TRAF2(2)	30910335	372	134	359	192	220	41	16	58	37	0	0.674	1.000	1.000
149	GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION		ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1	31	ACP1(3), ACP2(2), ACP5(3), ACPP(8), ALPI(8), ALPL(9), ALPP(9), ALPPL2(11), CYP19A1(10), CYP1A1(10), CYP1A2(10), CYP2A13(11), CYP2A6(11), CYP2A7(8), CYP2B6(16), CYP2C18(26), CYP2C19(35), CYP2C8(30), CYP2C9(35), CYP2D6(1), CYP2E1(13), CYP2F1(11), CYP2J2(5), CYP3A4(19), CYP3A5(10), CYP3A7(18), CYP4B1(20), CYP4F8(15), CYP51A1(1), PON1(14)	9717151	382	133	353	210	303	21	12	18	28	0	0.00151	1.000	1.000
150	GLYCEROLIPID_METABOLISM		ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C	45	ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH6(11), ADH7(13), ADHFE1(5), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AKR1A1(3), AKR1B1(2), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2), CEL(11), DGAT1(1), DGKA(3), DGKB(22), DGKD(9), DGKE(6), DGKG(16), DGKH(8), DGKQ(6), DGKZ(7), GK(6), GLA(1), GLB1(8), LCT(40), LIPC(8), LIPF(15), LIPG(6), LPL(3), PNLIP(7), PNLIPRP1(10), PNLIPRP2(2), PPAP2B(6), PPAP2C(8)	16139244	378	132	346	176	268	36	13	39	22	0	0.00369	1.000	1.000
151	HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY	Genes involved in adipocytokine signaling pathway	ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2	70	ACACB(17), ACSL1(4), ACSL3(6), ACSL4(2), ACSL5(20), ACSL6(13), ADIPOQ(3), ADIPOR1(5), ADIPOR2(1), AGRP(1), AKT1(3), AKT2(8), AKT3(4), CAMKK1(3), CAMKK2(7), CD36(4), CHUK(2), CPT1A(10), CPT1B(10), CPT1C(13), CPT2(1), G6PC(5), G6PC2(4), IKBKB(3), IRS1(5), IRS2(2), IRS4(12), JAK1(6), JAK2(9), JAK3(6), LEP(2), LEPR(22), MAPK10(8), MAPK8(1), MAPK9(5), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NPY(4), PCK1(23), PCK2(4), POMC(3), PPARA(6), PPARGC1A(20), PRKAA1(1), PRKAA2(24), PRKAB1(2), PRKAB2(2), PRKAG1(2), PRKAG2(7), PRKAG3(10), PRKCQ(16), PTPN11(9), RELA(4), RXRA(4), RXRB(4), RXRG(5), SLC2A1(4), SLC2A4(8), SOCS3(2), STAT3(10), STK11(3), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF2(2), TYK2(7)	27751707	434	132	419	244	270	44	22	47	51	0	0.569	1.000	1.000
152	NFATPATHWAY	Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK.	ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1	51	ACTA1(4), AGT(5), AKT1(3), CALM1(1), CALM2(1), CALR(1), CAMK1(4), CAMK1G(9), CAMK4(10), CREBBP(20), CSNK1A1(2), EDN1(8), ELSPBP1(4), F2(9), FGF2(2), FKBP1A(2), GATA4(2), GSK3B(2), HAND1(2), HAND2(5), HRAS(3), IGF1(11), LIF(2), MAP2K1(10), MAPK1(4), MAPK14(5), MAPK3(1), MAPK8(1), MEF2C(2), MYH2(77), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NKX2-5(1), NPPA(3), PIK3CA(8), PIK3R1(3), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RAF1(8), RPS6KB1(2), SYT1(19)	16985356	335	131	313	183	235	26	15	33	25	1	0.494	1.000	1.000
153	NO1PATHWAY	Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions.	ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF	28	ACTA1(4), AKT1(3), BDKRB2(9), CALM1(1), CALM2(1), CAV1(1), CHRM1(5), CHRNA1(5), FLT1(33), FLT4(23), KDR(42), NOS3(16), PDE2A(13), PDE3A(24), PDE3B(6), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKG1(12), PRKG2(13), RYR2(84), SLC7A1(3), SYT1(19), TNNI1(1)	13607606	340	130	321	197	240	26	10	32	31	1	0.338	1.000	1.000
154	SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	Genes related to PIP3 signaling in cardiac myocytes	AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	61	AKT1(3), AKT2(8), AKT3(4), CDC42(2), CDKN1B(1), CREB3(1), CREB5(9), ERBB4(47), F2RL2(6), GAB1(4), GRB2(2), GSK3B(2), IFI27(2), IGF1(11), IGFBP1(3), INPPL1(15), IRS1(5), IRS2(2), IRS4(12), MET(19), MYC(5), NOLC1(4), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PARD3(15), PARD6A(1), PDK1(2), PIK3CA(8), PIK3CD(7), PPP1R13B(6), PREX1(7), PTK2(8), PTPN1(4), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(1), SLC2A4(8), SOS1(8), SOS2(11), TSC1(5), TSC2(11), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3)	25365237	369	130	354	182	224	36	17	52	39	1	0.277	1.000	1.000
155	HSA04340_HEDGEHOG_SIGNALING_PATHWAY	Genes involved in Hedgehog signaling pathway	BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2	55	BMP2(4), BMP4(3), BMP5(25), BMP6(10), BMP7(2), BMP8A(2), BMP8B(1), BTRC(4), CSNK1A1(2), CSNK1A1L(5), CSNK1D(1), CSNK1E(4), CSNK1G1(4), CSNK1G2(2), CSNK1G3(3), DHH(1), FBXW11(5), GLI1(14), GLI2(36), GLI3(15), GSK3B(2), HHIP(21), IHH(2), LRP2(87), PRKACA(3), PRKACB(4), PRKACG(8), PRKX(3), PTCH1(8), PTCH2(16), RAB23(1), SHH(4), SMO(10), STK36(13), SUFU(2), WNT1(2), WNT10A(7), WNT10B(5), WNT11(4), WNT16(1), WNT2(7), WNT2B(4), WNT3(5), WNT3A(6), WNT4(2), WNT5A(5), WNT5B(5), WNT6(2), WNT7A(13), WNT7B(6), WNT8A(7), WNT8B(7), WNT9A(3), WNT9B(3), ZIC2(2)	20127806	423	129	402	208	292	37	19	41	34	0	0.0342	1.000	1.000
156	HSA00240_PYRIMIDINE_METABOLISM	Genes involved in pyrimidine metabolism	AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1	85	AICDA(9), CAD(15), CANT1(9), CDA(2), CTPS(2), CTPS2(3), DCTD(2), DHODH(3), DPYD(56), DPYS(22), ENTPD1(10), ENTPD3(6), ENTPD4(4), ENTPD5(1), ENTPD6(4), ENTPD8(2), NME6(2), NME7(4), NT5C1A(3), NT5C1B(22), NT5C2(3), NT5C3(2), NT5E(4), NT5M(2), PNPT1(1), POLA1(2), POLA2(8), POLD1(6), POLD2(2), POLD3(4), POLE(15), POLE2(3), POLR1A(11), POLR1B(8), POLR1C(1), POLR2A(11), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(4), POLR3B(17), POLR3G(1), POLR3GL(1), POLR3H(1), POLR3K(1), PRIM1(3), RRM1(3), RRM2(2), RRM2B(2), TK2(1), TXNRD1(5), TXNRD2(3), TYMS(1), UCK1(2), UMPS(1), UPB1(6), UPP2(5), UPRT(1)	26807625	345	128	327	180	221	32	17	48	27	0	0.349	1.000	1.000
157	HSA04115_P53_SIGNALING_PATHWAY	Genes involved in p53 signaling pathway	APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3	61	APAF1(6), ATM(12), ATR(20), BAI1(14), BAX(3), CASP3(2), CASP8(8), CASP9(3), CCNB2(3), CCNB3(28), CCND1(1), CCND2(5), CCND3(2), CCNE1(4), CCNE2(12), CCNG1(1), CDK4(5), CDK6(2), CDKN1A(4), CHEK1(2), CHEK2(3), CYCS(1), DDB2(3), EI24(3), FAS(5), GADD45B(2), GTSE1(9), IGF1(11), IGFBP3(2), LRDD(4), MDM2(3), MDM4(2), PERP(2), PPM1D(2), RFWD2(4), RPRM(1), RRM2(2), RRM2B(2), SERPINB5(8), SERPINE1(5), SESN2(6), SESN3(1), SFN(1), STEAP3(6), THBS1(27), TNFRSF10B(2), TP53I3(2), TP73(5), TSC2(11), ZMAT3(1)	20934390	273	128	264	133	162	22	18	45	25	1	0.382	1.000	1.000
158	SIG_BCR_SIGNALING_PATHWAY	Members of the BCR signaling pathway	AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1	46	AKT1(3), AKT2(8), AKT3(4), BCL2(2), BCR(10), BLNK(12), BTK(15), CD19(7), CD22(22), CD81(2), CR2(32), CSK(1), DAG1(5), FLOT1(2), GRB2(2), GSK3B(2), INPP5D(31), ITPR1(29), ITPR2(17), ITPR3(6), LYN(6), MAP4K1(9), MAPK1(4), MAPK3(1), NFATC1(15), NFATC2(9), NR0B2(6), PDK1(2), PIK3CA(8), PIK3CD(7), PIK3R1(3), PLCG2(25), PPP1R13B(6), PPP3CA(5), PPP3CB(4), PPP3CC(2), PTPRC(30), RAF1(8), SHC1(1), SOS1(8), SOS2(11), SYK(14), VAV1(15)	24674181	411	128	396	195	268	30	24	45	43	1	0.0198	1.000	1.000
159	GLUCONEOGENESIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH6(11), ADH7(13), ADHFE1(5), AKR1A1(3), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH9A1(2), ALDOA(2), ALDOB(12), ALDOC(3), BPGM(2), DLAT(2), DLD(2), ENO1(4), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(5), GAPDH(1), GCK(17), GPI(3), HK1(3), HK2(12), HK3(13), LDHA(5), LDHB(2), LDHC(5), PDHA1(3), PDHA2(17), PDHB(1), PFKM(1), PGK1(4), PGM1(4), PGM3(1), PKLR(11), PKM2(5)	16333330	310	127	282	133	218	30	14	29	19	0	0.000102	1.000	1.000
160	GLYCOLYSIS		ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1	53	ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH6(11), ADH7(13), ADHFE1(5), AKR1A1(3), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH9A1(2), ALDOA(2), ALDOB(12), ALDOC(3), BPGM(2), DLAT(2), DLD(2), ENO1(4), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(5), GAPDH(1), GCK(17), GPI(3), HK1(3), HK2(12), HK3(13), LDHA(5), LDHB(2), LDHC(5), PDHA1(3), PDHA2(17), PDHB(1), PFKM(1), PGK1(4), PGM1(4), PGM3(1), PKLR(11), PKM2(5)	16333330	310	127	282	133	218	30	14	29	19	0	0.000102	1.000	1.000
161	HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION	Genes involved in antigen processing and presentation	B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP	73	B2M(5), CALR(1), CANX(1), CD4(6), CD74(6), CD8A(2), CD8B(7), CIITA(15), CTSL1(1), CTSS(6), HLA-A(6), HLA-B(5), HLA-C(1), HLA-DMA(4), HLA-DMB(7), HLA-DOA(4), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(2), HLA-DQA1(7), HLA-DQA2(7), HLA-DQB1(5), HLA-DRA(11), HLA-DRB1(3), HLA-DRB5(1), HLA-E(1), HLA-F(6), HLA-G(3), HSP90AA1(2), HSP90AB1(5), HSPA5(5), IFI30(2), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(9), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(5), IFNA8(3), KIR2DL1(21), KIR2DL3(6), KIR2DL4(3), KIR2DS4(15), KIR3DL1(17), KIR3DL2(2), KIR3DL3(6), KLRC1(4), KLRC2(1), KLRC3(11), KLRC4(5), KLRD1(5), LGMN(5), LTA(2), NFYA(1), NFYB(3), NFYC(1), PDIA3(3), PSME2(4), RFX5(5), RFXANK(1), RFXAP(1), TAP1(1), TAP2(13), TAPBP(2)	15365062	319	127	308	179	212	29	15	34	29	0	0.293	1.000	1.000
162	ST_FAS_SIGNALING_PATHWAY	The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand.	ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2	58	ALG2(4), BAX(3), BTK(15), CAD(15), CASP10(4), CASP3(2), CASP8(8), CASP8AP2(7), CDK2AP1(2), CSNK1A1(2), DAXX(9), DEDD(1), DEDD2(3), DFFA(2), DIABLO(1), EGFR(22), EPHB2(29), FAF1(7), FAIM2(5), HSPB1(2), IL1A(4), IL8(1), MAP2K4(4), MAP2K7(4), MAP3K1(2), MAP3K5(16), MAPK1(4), MAPK10(8), MAPK8(1), MAPK8IP1(4), MAPK8IP2(7), MAPK8IP3(8), MAPK9(5), MET(19), NFAT5(7), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), NR0B2(6), PTPN13(12), RALBP1(2), RIPK1(1), ROCK1(5), SMPD1(3), TNFRSF6B(2), TPX2(9), TRAF2(2), TUFM(5)	23980588	305	125	298	171	182	23	17	45	38	0	0.837	1.000	1.000
163	HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM	Genes involved in porphyrin and chlorophyll metabolism	ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS	40	ALAD(5), ALAS1(1), ALAS2(5), BLVRA(2), BLVRB(1), COX10(5), COX15(4), CP(11), CPOX(4), EPRS(9), FECH(3), FTH1(3), FTMT(7), GUSB(3), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), MMAB(2), PPOX(3), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(8), UGT1A9(10), UGT2A1(18), UGT2A3(24), UGT2B10(36), UGT2B11(19), UGT2B28(24), UGT2B4(31), UGT2B7(17), UROS(1)	13386242	324	124	301	123	225	28	18	20	32	1	0.000185	1.000	1.000
164	SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes	AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1	31	AKT1(3), AKT2(8), AKT3(4), BCR(10), BTK(15), CD19(7), DAPP1(5), FLOT1(2), GAB1(4), ITPR1(29), ITPR2(17), ITPR3(6), LYN(6), NR0B2(6), PDK1(2), PIK3CA(8), PITX2(4), PLCG2(25), PPP1R13B(6), PREX1(7), PTPRC(30), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KB1(2), SAG(9), SYK(14), TEC(10), VAV1(15)	17915538	269	124	253	157	180	19	16	28	26	0	0.366	1.000	1.000
165	VITCBPATHWAY	Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium.	COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3	11	COL4A1(57), COL4A2(30), COL4A3(37), COL4A4(91), COL4A5(53), COL4A6(32), P4HB(2), SLC23A1(4), SLC23A2(4), SLC2A1(4), SLC2A3(7)	8332233	321	124	302	86	265	14	9	20	13	0	0.0976	1.000	1.000
166	WNT_SIGNALING	Wnt signaling genes	APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B	57	APC(19), AXIN1(10), CCND1(1), CCND2(5), CCND3(2), CSNK1E(4), CTNNB1(11), DVL2(3), DVL3(7), FBXW2(2), FZD1(4), FZD10(2), FZD2(5), FZD5(2), FZD6(2), FZD7(4), FZD8(4), FZD9(1), GSK3B(2), JUN(1), LDLR(14), MAPK10(8), MAPK9(5), MYC(5), PAFAH1B1(4), PLAU(3), PPP2R5C(4), PPP2R5E(4), PRKCA(10), PRKCD(4), PRKCE(6), PRKCG(13), PRKCH(10), PRKCI(8), PRKCQ(16), PRKCZ(5), PRKD1(3), RHOA(1), SFRP4(6), TCF7(1), WNT1(2), WNT10A(7), WNT10B(5), WNT11(4), WNT16(1), WNT2(7), WNT2B(4), WNT3(5), WNT4(2), WNT5A(5), WNT5B(5), WNT6(2), WNT7A(13), WNT7B(6)	19774605	289	124	283	161	181	29	8	34	37	0	0.392	1.000	1.000
167	INOSITOL_PHOSPHATE_METABOLISM		IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2	23	IMPA1(1), INPP1(2), INPP4A(5), INPP4B(2), INPP5A(4), INPPL1(15), ITPKB(7), MIOX(3), OCRL(4), PIK3C2A(6), PIK3C2B(13), PIK3C2G(43), PIK3CA(8), PIK3CB(21), PIK3CG(24), PLCB1(48), PLCB2(9), PLCB3(4), PLCB4(69), PLCD1(3), PLCG1(9), PLCG2(25)	14902285	325	123	297	140	226	14	14	39	31	1	0.00633	1.000	1.000
168	SIG_CHEMOTAXIS	Genes related to chemotaxis	ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL	43	ACTR2(3), ACTR3(2), AKT1(3), AKT2(8), AKT3(4), ANGPTL2(2), ARHGAP1(2), ARHGAP4(2), ARHGEF11(17), BTK(15), CDC42(2), CFL1(1), GDI1(1), GDI2(2), INPPL1(15), ITPR1(29), ITPR2(17), ITPR3(6), LIMK1(4), MYLK(39), MYLK2(10), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PDK1(2), PIK3CA(8), PIK3CD(7), PIK3CG(24), PIK3R1(3), PITX2(4), PPP1R13B(6), RACGAP1(3), RHO(2), ROCK1(5), ROCK2(12), SAG(9), WASF1(4), WASL(5)	23092803	354	123	333	163	233	31	12	49	28	1	0.0128	1.000	1.000
169	ST_T_CELL_SIGNAL_TRANSDUCTION	On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation.	CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70	44	CBL(8), CD28(1), CD3D(5), CSK(1), CTLA4(2), DAG1(5), EPHB2(29), FBXW7(11), GRAP2(4), GRB2(2), ITK(20), ITPKB(7), LAT(1), LCK(12), LCP2(9), MAPK1(4), NCK1(1), NFAT5(7), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), PLCG1(9), PTPRC(30), RAF1(8), RASGRP1(7), RASGRP2(6), RASGRP3(13), RASGRP4(10), SOS1(8), SOS2(11), VAV1(15), ZAP70(8)	18516307	351	123	336	165	220	29	18	47	37	0	0.113	1.000	1.000
170	SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES	Genes related to regulation of the actin cytoskeleton	ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL	35	ACTG1(5), ACTG2(4), ACTR2(3), ACTR3(2), AKT1(3), ANGPTL2(2), CDC42(2), CFL1(1), FLNA(15), FLNC(56), FSCN1(4), FSCN2(2), FSCN3(10), GDI1(1), GDI2(2), LIMK1(4), MYH2(77), MYLK(39), MYLK2(10), PAK1(4), PAK2(8), PAK3(9), PAK4(4), PAK6(4), PAK7(47), RHO(2), ROCK1(5), ROCK2(12), VASP(3), WASF1(4), WASL(5)	15936697	349	122	324	185	241	44	9	33	22	0	0.0356	1.000	1.000
171	TYROSINE_METABOLISM		ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR	32	ABP1(18), ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH6(11), ADH7(13), ADHFE1(5), ALDH1A3(2), ALDH3A1(5), ALDH3B1(2), ALDH3B2(7), AOC2(7), AOC3(8), AOX1(21), COMT(3), DBH(13), DCT(3), DDC(12), FAH(4), GOT1(6), GOT2(5), HGD(12), HPD(5), MAOA(3), MAOB(13), PNMT(4), TAT(17), TH(9), TPO(40), TYR(8)	10557864	335	122	311	161	255	26	17	21	16	0	0.00158	1.000	1.000
172	HSA00590_ARACHIDONIC_ACID_METABOLISM	Genes involved in arachidonic acid metabolism	AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1	51	AKR1C3(9), ALOX12(5), ALOX12B(13), ALOX15(8), ALOX15B(8), ALOX5(8), CBR3(1), CYP2B6(16), CYP2C18(26), CYP2C19(35), CYP2C8(30), CYP2C9(35), CYP2E1(13), CYP2J2(5), CYP2U1(1), CYP4A11(23), CYP4A22(19), CYP4F2(12), CYP4F3(19), EPHX2(4), GGT1(6), GPX1(7), GPX3(3), GPX5(12), GPX6(15), LTA4H(4), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PTGDS(2), PTGES2(1), PTGIS(12), PTGS1(17), PTGS2(10), TBXAS1(11)	12915262	447	121	419	284	355	27	6	27	31	1	0.168	1.000	1.000
173	ST_B_CELL_ANTIGEN_RECEPTOR	B cell receptors bind antigens and promote B cell activation.	AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1	39	AKT1(3), AKT2(8), AKT3(4), BCR(10), BLNK(12), BTK(15), CD19(7), CSK(1), DAG1(5), EPHB2(29), GRB2(2), ITPKB(7), LYN(6), MAP2K1(10), MAP2K2(3), MAPK1(4), NFAT5(7), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PI3(6), PIK3CA(8), PIK3CD(7), PIK3R1(3), PLCG2(25), PPP1R13B(6), RAF1(8), SERPINA4(14), SHC1(1), SOS1(8), SOS2(11), SYK(14), VAV1(15)	17654407	280	121	268	148	173	21	15	41	29	1	0.429	1.000	1.000
174	BLOOD_CLOTTING_CASCADE		F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF	20	F10(8), F11(12), F12(1), F13B(23), F2(9), F5(30), F7(7), F8(43), F9(12), FGA(38), FGB(10), FGG(7), LPA(47), PLAT(3), PLAU(3), PLG(30), SERPINB2(16), SERPINE1(5), SERPINF2(6), VWF(49)	11731017	359	119	340	146	254	27	22	24	31	1	0.0135	1.000	1.000
175	HSA00380_TRYPTOPHAN_METABOLISM	Genes involved in tryptophan metabolism	AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22	58	AADAT(5), AANAT(1), ABP1(18), ACAT2(1), ACMSD(10), AFMID(2), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), AOC2(7), AOC3(8), AOX1(21), ASMT(6), CARM1(6), CAT(5), CYP1A1(10), CYP1A2(10), CYP1B1(2), DDC(12), ECHS1(2), EHHADH(6), GCDH(5), HAAO(3), HADHA(8), HEMK1(4), HSD17B10(2), HSD17B4(6), INMT(8), KMO(8), KYNU(11), LCMT1(4), LNX1(17), MAOA(3), MAOB(13), METTL2B(7), METTL6(2), NFX1(6), OGDH(11), OGDHL(36), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), TDO2(5), TPH1(5), TPH2(12), WARS(4), WARS2(4), WBSCR22(1)	20221639	373	119	359	192	259	30	19	42	23	0	0.0975	1.000	1.000
176	RIBOSOMAL_PROTEINS		ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC	93	ANK2(48), B3GALT4(2), CDR1(12), DGKI(23), IL6ST(10), MRPL19(1), PIGK(6), RPL10(4), RPL11(2), RPL13A(2), RPL14(1), RPL15(2), RPL18(3), RPL18A(1), RPL19(1), RPL21(1), RPL22(2), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL38(1), RPL39(1), RPL3L(3), RPL4(5), RPL5(6), RPL6(1), RPL7(2), RPL7A(1), RPLP0(1), RPS10(1), RPS11(1), RPS13(1), RPS15(1), RPS16(1), RPS18(1), RPS2(2), RPS20(2), RPS23(1), RPS24(1), RPS27(1), RPS29(1), RPS3A(1), RPS5(1), RPS6(1), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KA6(15), RPS6KB1(2), RPS6KB2(3), RPS7(4), RPS8(1), RPSA(1), SLC36A2(7), TBC1D10C(5), TSPAN9(3), UBB(1), UBC(6)	17346050	233	119	223	135	144	22	13	32	22	0	0.712	1.000	1.000
177	HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	Genes involved in epithelial cell signaling in Helicobacter pylori infection	ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1	64	ADAM10(7), ADAM17(1), ATP6AP1(2), ATP6V0A1(9), ATP6V0A2(4), ATP6V0A4(19), ATP6V0D2(8), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), CASP3(2), CDC42(2), CHUK(2), CSK(1), EGFR(22), F11R(5), GIT1(4), HBEGF(1), IGSF5(10), IKBKB(3), IL8(1), JAM2(10), JAM3(2), JUN(1), LYN(6), MAP2K4(4), MAP3K14(3), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK8(1), MAPK9(5), MET(19), NFKB1(7), NFKB2(4), NFKBIA(2), NOD1(6), PAK1(4), PLCG1(9), PLCG2(25), PTPN11(9), PTPRZ1(22), RELA(4), SRC(1), TCIRG1(3), TJP1(11)	23401565	317	118	312	194	199	28	16	46	28	0	0.904	1.000	1.000
178	ST_MYOCYTE_AD_PATHWAY	Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects.	ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1	22	ADRB1(5), AKT1(3), APC(19), CAMP(1), DAG1(5), DLG4(4), EPHB2(29), GNAI1(1), GNAQ(4), ITPR1(29), ITPR2(17), ITPR3(6), KCNJ3(18), KCNJ5(12), KCNJ9(4), MAPK1(4), PITX2(4), PTX3(1), RHO(2), RYR1(87)	15068624	255	118	246	169	176	25	12	19	23	0	0.620	1.000	1.000
179	ARGININE_AND_PROLINE_METABOLISM		ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS	43	ABP1(18), AGMAT(3), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH4A1(6), ALDH9A1(2), AOC2(7), AOC3(8), ARG1(1), ARG2(1), ASL(6), CKM(2), CKMT1A(1), CKMT2(5), CPS1(21), DAO(10), GAMT(4), GATM(5), GLUD1(2), GOT1(6), GOT2(5), MAOA(3), MAOB(13), NOS1(58), NOS3(16), OAT(3), ODC1(3), OTC(4), P4HA1(9), P4HA2(4), P4HA3(12), P4HB(2), PYCR1(1), RARS(7), SMS(5)	14710616	289	117	277	166	190	33	15	24	27	0	0.304	1.000	1.000
180	OVARIAN_INFERTILITY_GENES		ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2	25	ATM(12), BMPR1B(3), CCND2(5), CDK4(5), CDKN1B(1), DAZL(4), DMC1(10), EGR1(4), ESR2(6), FSHR(15), GJA4(4), INHA(4), LHCGR(24), MLH1(6), MSH5(14), NCOR1(19), NR5A1(7), NRIP1(8), PGR(15), PRLR(29), PTGER2(6), SMPD1(3), VDR(2), ZP2(13)	11659638	219	117	198	114	151	15	4	26	23	0	0.616	1.000	1.000
181	ST_JNK_MAPK_PATHWAY	JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins.	AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK	37	AKT1(3), ATF2(5), CDC42(2), DLD(2), DUSP10(6), DUSP4(1), DUSP8(3), GAB1(4), GCK(17), IL1R1(11), JUN(1), MAP2K4(4), MAP2K5(3), MAP2K7(4), MAP3K1(2), MAP3K10(8), MAP3K11(6), MAP3K12(3), MAP3K13(10), MAP3K2(6), MAP3K3(6), MAP3K4(17), MAP3K5(16), MAP3K7(1), MAP3K9(22), MAPK10(8), MAPK7(4), MAPK8(1), MAPK9(5), MYEF2(4), NFATC3(9), NR2C2(2), PAPPA(50), SHC1(1), TRAF6(4), ZAK(6)	16528318	257	117	248	117	178	22	7	28	21	1	0.357	1.000	1.000
182	FMLPPATHWAY	The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1	36	CALM1(1), CALM2(1), CAMK1(4), CAMK1G(9), ELK1(2), FPR1(18), GNA15(5), HRAS(3), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K6(3), MAP3K1(2), MAPK1(4), MAPK14(5), MAPK3(1), NCF1(1), NCF2(7), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB1(7), NFKBIA(2), PAK1(4), PIK3C2G(43), PLCB1(48), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAF1(8), RELA(4), SYT1(19)	12577006	278	116	255	119	198	15	9	28	28	0	0.0302	1.000	1.000
183	NOS1PATHWAY	Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase.	CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1	21	CALM1(1), CALM2(1), DLG4(4), GRIN1(7), GRIN2A(86), GRIN2B(53), GRIN2C(8), GRIN2D(6), NOS1(58), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), SYT1(19)	8505068	286	116	268	181	213	28	5	19	21	0	0.332	1.000	1.000
184	HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS	Genes involved in pentose and glucuronate interconversions	AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB	24	AKR1B1(2), GUSB(3), UGDH(1), UGP2(1), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(8), UGT1A9(10), UGT2A1(18), UGT2A3(24), UGT2B10(36), UGT2B11(19), UGT2B28(24), UGT2B4(31), UGT2B7(17), XYLB(4)	8396615	261	115	239	104	188	21	14	15	22	1	0.00187	1.000	1.000
185	BETA_ALANINE_METABOLISM		ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1	27	ABAT(9), ABP1(18), ACADL(4), ACADM(5), ACADSB(6), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2), AOC2(7), AOC3(8), CNDP1(8), DPYD(56), DPYS(22), ECHS1(2), EHHADH(6), GAD1(13), GAD2(7), HADHA(8), MLYCD(2), SDS(2), SMS(5), UPB1(6)	9726245	232	114	218	113	155	21	12	29	15	0	0.112	1.000	1.000
186	GLYCOLYSIS_AND_GLUCONEOGENESIS	Genes involved in glycolysis and gluconeogenesis	ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1	43	ALDOA(2), ALDOB(12), ALDOC(3), DLAT(2), DLD(2), ENO1(4), ENO2(4), ENO3(4), FBP1(2), FBP2(2), G6PC(5), GAPDH(1), GAPDHS(1), GCK(17), GOT1(6), GOT2(5), GPI(3), HK1(3), HK2(12), HK3(13), LDHA(5), LDHAL6B(7), LDHB(2), LDHC(5), MDH1(1), MDH2(4), PC(12), PCK1(23), PDHA1(3), PDHA2(17), PDHB(1), PDHX(2), PFKL(4), PFKM(1), PGAM2(3), PGK1(4), PGK2(27), PKLR(11), PKM2(5), TNFAIP1(1)	14224075	241	113	226	117	175	18	12	20	16	0	0.00273	1.000	1.000
187	HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM	Genes involved in glycerophospholipid metabolism	ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1	63	ACHE(6), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPAT6(2), CDS1(9), CDS2(4), CHAT(14), CHKA(2), CHKB(3), CHPT1(1), CRLS1(1), DGKA(3), DGKB(22), DGKD(9), DGKE(6), DGKG(16), DGKH(8), DGKI(23), DGKQ(6), DGKZ(7), ESCO1(1), ESCO2(2), ETNK1(4), GNPAT(2), GPAM(5), GPD1(8), GPD1L(2), GPD2(2), LYPLA1(1), LYPLA2(1), MYST3(15), MYST4(14), NAT6(2), PCYT1A(3), PCYT1B(7), PEMT(2), PISD(2), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PLD1(11), PLD2(5), PNPLA3(2), PPAP2B(6), PPAP2C(8), PTDSS2(1), SH3GLB1(2)	21827869	325	113	310	183	211	29	9	42	34	0	0.630	1.000	1.000
188	LAIRPATHWAY	The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation.	BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1	16	C3(46), C5(14), C6(56), C7(43), ICAM1(2), IL1A(4), IL6(2), IL8(1), ITGA4(36), ITGAL(24), ITGB1(4), ITGB2(13), SELP(30), SELPLG(8), TNF(1), VCAM1(16)	8229017	300	113	272	125	220	9	14	26	30	1	0.00185	1.000	1.000
189	HSA00512_O_GLYCAN_BIOSYNTHESIS	Genes involved in O-glycan biosynthesis	B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17	30	B4GALT5(2), C1GALT1(6), C1GALT1C1(2), GALNT1(4), GALNT10(6), GALNT11(2), GALNT12(8), GALNT13(25), GALNT14(27), GALNT2(6), GALNT3(3), GALNT4(4), GALNT5(9), GALNT6(15), GALNT7(5), GALNT8(23), GALNT9(5), GALNTL1(4), GALNTL2(19), GALNTL4(6), GALNTL5(14), GCNT1(6), GCNT3(5), GCNT4(4), OGT(10), ST3GAL1(6), ST3GAL2(1), ST6GALNAC1(5), WBSCR17(37)	10798624	269	112	253	129	202	13	6	24	24	0	0.121	1.000	1.000
190	HSA04150_MTOR_SIGNALING_PATHWAY	Genes involved in mTOR signaling pathway	AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC	42	AKT1(3), AKT2(8), AKT3(4), CAB39(1), EIF4B(4), EIF4EBP1(1), FIGF(4), HIF1A(5), IGF1(11), MAPK1(4), MAPK3(1), PDPK1(4), PGF(1), PIK3CA(8), PIK3CB(21), PIK3CD(7), PIK3CG(24), PIK3R1(3), PIK3R2(5), PIK3R3(1), PIK3R5(14), PRKAA1(1), PRKAA2(24), RHEB(1), RICTOR(10), RPS6(1), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KA6(15), RPS6KB1(2), RPS6KB2(3), STK11(3), TSC1(5), TSC2(11), ULK1(7), ULK2(6), ULK3(1), VEGFA(5), VEGFB(1)	16826415	245	112	231	110	144	17	11	47	24	2	0.164	1.000	1.000
191	PYRIMIDINE_METABOLISM		AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1	55	CAD(15), CANT1(9), CDA(2), CTPS(2), CTPS2(3), DCTD(2), DHODH(3), DPYD(56), DPYS(22), ENTPD1(10), NT5E(4), NT5M(2), POLD1(6), POLD2(2), POLE(15), POLG(8), POLL(7), POLQ(23), POLR1B(8), POLR2A(11), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(2), RRM1(3), RRM2(2), TK2(1), TXNRD1(5), TYMS(1), UCK1(2), UMPS(1), UNG(3), UPB1(6)	19182339	257	112	241	115	164	23	11	36	23	0	0.0399	1.000	1.000
192	APOPTOSIS		APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3	65	APAF1(6), BAX(3), BCL2(2), BCL2L11(5), BIRC2(5), BIRC3(7), BIRC5(1), BNIP3L(2), CASP1(4), CASP10(4), CASP2(1), CASP3(2), CASP4(1), CASP7(4), CASP8(8), CASP9(3), CHUK(2), CYCS(1), DFFA(2), DFFB(3), FAS(5), FASLG(14), GZMB(3), HELLS(5), IKBKB(3), IRF1(1), IRF2(5), IRF3(3), IRF4(3), IRF5(4), IRF6(13), IRF7(7), JUN(1), LTA(2), MAP2K4(4), MAP3K1(2), MAPK10(8), MDM2(3), MYC(5), NFKB1(7), NFKBIA(2), NFKBIB(1), PLEKHG5(10), PRF1(11), RELA(4), RIPK1(1), TNF(1), TNFRSF10B(2), TNFRSF1A(3), TNFRSF1B(3), TNFRSF21(10), TNFRSF25(5), TNFSF10(7), TP73(5), TRAF1(6), TRAF2(2), TRAF3(5)	18830432	242	111	240	132	161	26	13	24	18	0	0.573	1.000	1.000
193	FCER1PATHWAY	In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release.	BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	37	BTK(15), CALM1(1), CALM2(1), ELK1(2), FCER1A(12), FCER1G(1), FOS(2), GRB2(2), HRAS(3), JUN(1), LYN(6), MAP2K1(10), MAP2K4(4), MAP2K7(4), MAP3K1(2), MAPK1(4), MAPK3(1), MAPK8(1), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PAK2(8), PIK3CA(8), PIK3R1(3), PLA2G4A(11), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), RAF1(8), SHC1(1), SOS1(8), SYK(14), SYT1(19), VAV1(15)	14341253	233	111	221	106	152	12	12	34	22	1	0.349	1.000	1.000
194	HSA00120_BILE_ACID_BIOSYNTHESIS	Genes involved in bile acid biosynthesis	ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2	38	ACAA1(5), ACAA2(1), ACAD8(1), ACAD9(1), ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), AKR1B10(8), AKR1C4(9), AKR1D1(17), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), BAAT(10), CEL(11), CYP27A1(4), CYP7A1(8), HADHB(4), HSD3B7(3), LIPA(4), RDH11(2), RDH12(2), RDH13(3), SLC27A5(6), SOAT1(3), SOAT2(6), SRD5A1(2), SRD5A2(6)	10626059	259	111	234	119	171	28	19	23	18	0	0.00809	1.000	1.000
195	HSA00410_BETA_ALANINE_METABOLISM	Genes involved in beta-alanine metabolism	ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1	25	ABAT(9), ABP1(18), ACADM(5), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), AOC2(7), AOC3(8), CNDP1(8), DPYD(56), DPYS(22), ECHS1(2), EHHADH(6), GAD1(13), GAD2(7), HADHA(8), HIBCH(1), MLYCD(2), SMS(5), UPB1(6)	9047075	215	111	200	110	142	20	13	27	13	0	0.211	1.000	1.000
196	HSA00591_LINOLEIC_ACID_METABOLISM	Genes involved in linoleic acid metabolism	AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14	31	AKR1B10(8), ALOX15(8), ALOX5(8), CYP1A2(10), CYP2C18(26), CYP2C19(35), CYP2C8(30), CYP2C9(35), CYP2E1(13), CYP2J2(5), CYP3A4(19), CYP3A43(15), CYP3A5(10), CYP3A7(18), HSD3B7(3), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), RDH11(2), RDH12(2), RDH13(3)	7978158	307	111	287	173	244	12	9	14	28	0	0.0428	1.000	1.000
197	GLYCEROPHOSPHOLIPID_METABOLISM		ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C	49	ACHE(6), AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPS(3), CDS1(9), CDS2(4), CHAT(14), CHKA(2), CHKB(3), CLC(3), CPT1B(10), DGKA(3), DGKB(22), DGKD(9), DGKE(6), DGKG(16), DGKH(8), DGKQ(6), DGKZ(7), ETNK1(4), GNPAT(2), GPD1(8), GPD2(2), LGALS13(4), LYPLA1(1), LYPLA2(1), PAFAH1B1(4), PAFAH2(2), PCYT1A(3), PCYT1B(7), PEMT(2), PISD(2), PLA2G1B(1), PLA2G2A(2), PLA2G2E(4), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PLCB2(9), PLCG1(9), PLCG2(25), PPAP2B(6), PPAP2C(8)	16691191	292	110	281	151	204	19	8	36	25	0	0.0666	1.000	1.000
198	HSA00052_GALACTOSE_METABOLISM	Genes involved in galactose metabolism	AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2	32	AKR1B1(2), AKR1B10(8), B4GALT1(2), B4GALT2(2), G6PC(5), G6PC2(4), GAA(7), GALK1(1), GALK2(2), GALT(2), GANC(5), GCK(17), GLA(1), GLB1(8), HK1(3), HK2(12), HK3(13), HSD3B7(3), LALBA(7), LCT(40), MGAM(133), PFKL(4), PFKM(1), PGM1(4), PGM3(1), RDH11(2), RDH12(2), RDH13(3), UGP2(1)	12877943	295	110	279	162	216	27	7	29	16	0	0.0736	1.000	1.000
199	BIOPEPTIDESPATHWAY	Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases.	AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1	37	AGT(5), AGTR2(9), CALM1(1), CALM2(1), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CDK5(4), F2(9), FYN(6), GNA11(7), GNAI1(1), GRB2(2), HRAS(3), JAK2(9), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK14(5), MAPK3(1), MAPK8(1), MAPT(10), MYLK(39), PLCG1(9), PRKCA(10), PTK2B(10), RAF1(8), SHC1(1), SOS1(8), STAT1(4), STAT3(10), STAT5A(2), SYT1(19)	13854901	229	109	213	133	143	20	11	33	22	0	0.719	1.000	1.000
200	GALACTOSE_METABOLISM		AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3	24	AKR1B1(2), B4GALT1(2), B4GALT2(2), FBP2(2), G6PC(5), GAA(7), GALK1(1), GALK2(2), GALT(2), GANAB(5), GCK(17), GLA(1), GLB1(8), HK1(3), HK2(12), HK3(13), LALBA(7), LCT(40), MGAM(133), PFKM(1), PGM1(4), PGM3(1)	10858696	270	108	254	145	198	27	7	25	13	0	0.0582	1.000	1.000
201	PPARAPATHWAY	Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs).	ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF	50	ACOX1(7), APOA1(2), CD36(4), CPT1B(10), CREBBP(20), EHHADH(6), EP300(14), FABP1(6), HSD17B4(6), JUN(1), LPL(3), MAPK1(4), MAPK3(1), ME1(19), MYC(5), NCOA1(9), NCOR1(19), NCOR2(24), NFKBIA(2), NR0B2(6), NR1H3(3), NR2F1(8), NRIP1(8), PDGFA(1), PIK3CA(8), PIK3R1(3), PPARA(6), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), PTGS2(10), RB1(8), RELA(4), RXRA(4), SP1(5), STAT5A(2), STAT5B(4), TNF(1)	21204376	275	107	267	127	178	20	18	32	24	3	0.192	1.000	1.000
202	ST_ADRENERGIC	Adrenergic receptors respond to epinephrine and norepinephrine signaling.	AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC	33	AKT1(3), APC(19), AR(7), CAMP(1), CCL15(3), CCL16(1), DAG1(5), EGFR(22), GNA11(7), GNA15(5), GNAI1(1), GNAQ(4), ITPKB(7), ITPR1(29), ITPR2(17), ITPR3(6), KCNJ3(18), KCNJ5(12), KCNJ9(4), MAPK1(4), MAPK10(8), MAPK14(5), PHKA2(7), PIK3CA(8), PIK3CD(7), PIK3R1(3), PITX2(4), PTX3(1), RAF1(8), SRC(1)	17231824	227	107	219	137	139	19	13	28	27	1	0.765	1.000	1.000
203	ANDROGEN_AND_ESTROGEN_METABOLISM		AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	29	AKR1C4(9), AKR1D1(17), ARSB(1), ARSD(3), ARSE(5), CYP11B1(13), CYP11B2(13), HSD11B1(11), HSD11B2(2), HSD17B2(9), HSD17B3(5), HSD3B1(10), HSD3B2(10), SRD5A1(2), SRD5A2(6), STS(7), SULT1E1(12), SULT2A1(7), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(8), UGT1A9(10), UGT2B4(31)	8411787	254	106	235	116	173	27	16	15	22	1	0.00297	1.000	1.000
204	BILE_ACID_BIOSYNTHESIS		ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2	27	ACAA1(5), ACAA2(1), ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH6(11), ADH7(13), ADHFE1(5), AKR1C4(9), AKR1D1(17), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2), BAAT(10), CEL(11), CYP27A1(4), CYP7A1(8), HADHB(4), SOAT2(6), SRD5A1(2), SRD5A2(6)	7803745	229	106	206	96	152	24	14	22	17	0	0.00250	1.000	1.000
205	COMPLEMENT_ACTIVATION_CLASSICAL		C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1	11	C1QA(4), C1QB(3), C1R(13), C1S(15), C3(46), C5(14), C6(56), C7(43), C8B(43), C9(19), MASP1(8)	5947047	264	106	237	119	202	13	9	22	17	1	0.0349	1.000	1.000
206	SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	Genes related to the insulin receptor pathway	AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	47	AKT1(3), AKT2(8), AKT3(4), BRD4(19), CAP1(1), CBL(8), CDC42(2), F2RL2(6), FLOT1(2), GRB2(2), GSK3B(2), IGFBP1(3), INPPL1(15), IRS1(5), IRS2(2), IRS4(12), LNPEP(10), MAPK1(4), MAPK3(1), PARD3(15), PARD6A(1), PDK1(2), PIK3CA(8), PIK3CD(7), PIK3R1(3), PPYR1(12), PTPN1(4), RAF1(8), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KB1(2), SERPINB6(4), SFN(1), SHC1(1), SLC2A4(8), SORBS1(13), SOS1(8), SOS2(11), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3)	19483227	238	106	235	119	132	27	13	40	25	1	0.563	1.000	1.000
207	ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS	Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells.	AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3	41	AKT1(3), ATF1(4), CAMP(1), CREB3(1), CREB5(9), CREBBP(20), CRKL(2), DAG1(5), EGR1(4), EGR2(4), EGR3(2), EGR4(5), ELK1(2), FRS2(4), GNAQ(4), JUN(1), MAP1B(21), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK3(1), MAPK8(1), MAPK8IP1(4), MAPK8IP2(7), MAPK8IP3(8), MAPK9(5), NTRK1(15), OPN1LW(4), PIK3C2G(43), PIK3CA(8), PIK3CD(7), PIK3R1(3), PTPN11(9), RPS6KA3(2), SHC1(1), SRC(1), TERF2IP(1), TH(9)	16570309	241	106	231	119	162	17	8	30	23	1	0.307	1.000	1.000
208	ST_GA13_PATHWAY	G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2.	AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R	34	AKT1(3), AKT2(8), AKT3(4), ARHGEF11(17), BCL2(2), CDC42(2), DLG4(4), GNA13(1), LPA(47), MAP2K4(4), MAP3K1(2), MAP3K5(16), MAPK8(1), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PDK1(2), PHKA2(7), PI3(6), PIK3CB(21), PLD1(11), PLD2(5), PLD3(1), PTK2(8), RDX(1), ROCK1(5), ROCK2(12), SERPINA4(14), SRF(2), TBXA2R(4)	16383940	231	106	220	122	128	19	10	45	29	0	0.741	1.000	1.000
209	COMPPATHWAY	Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis.	BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2	12	C1QA(4), C1QB(3), C1R(13), C1S(15), C3(46), C5(14), C6(56), C7(43), C9(19), MASP1(8), MASP2(9), MBL2(12)	6118997	242	105	219	109	186	11	5	20	19	1	0.0404	1.000	1.000
210	GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE		CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8	13	CASR(56), GABBR1(7), GPRC5A(4), GPRC5B(5), GPRC5C(8), GPRC5D(2), GRM1(16), GRM2(7), GRM3(49), GRM4(19), GRM5(13), GRM7(32), GRM8(43)	6981213	261	105	243	183	192	18	12	23	16	0	0.227	1.000	1.000
211	HSA00650_BUTANOATE_METABOLISM	Genes involved in butanoate metabolism	AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14	45	AACS(7), AADAC(14), ABAT(9), ACADS(4), ACAT2(1), ACSM1(25), AKR1B10(8), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH5A1(10), ALDH7A1(9), ALDH9A1(2), BDH1(5), DDHD1(6), ECHS1(2), EHHADH(6), GAD1(13), GAD2(7), HADHA(8), HMGCL(4), HMGCS1(2), HMGCS2(17), HSD17B10(2), HSD17B4(6), HSD3B7(3), ILVBL(4), L2HGDH(3), OXCT1(4), OXCT2(3), PDHA1(3), PDHA2(17), PDHB(1), PLA1A(9), PPME1(1), PRDX6(4), RDH11(2), RDH12(2), RDH13(3)	13600875	247	105	238	123	168	25	13	22	19	0	0.104	1.000	1.000
212	ST_WNT_BETA_CATENIN_PATHWAY	Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival.	AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1	30	AKT1(3), AKT2(8), AKT3(4), ANKRD6(3), APC(19), AXIN1(10), AXIN2(3), CER1(12), CSNK1A1(2), CTNNB1(11), DACT1(10), DKK1(2), DKK2(14), DKK3(4), DKK4(3), FSTL1(2), GSK3B(2), LRP1(31), MVP(10), NKD1(8), NKD2(5), PIN1(1), PSEN1(1), PTPRA(7), SENP2(11), SFRP1(2), TSHB(6), WIF1(7)	13354987	201	105	197	105	117	25	8	26	25	0	0.520	1.000	1.000
213	TCRPATHWAY	T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation.	CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70	41	CALM1(1), CALM2(1), CD3D(5), CD3E(2), CD3G(1), ELK1(2), FOS(2), FYN(6), GRB2(2), HRAS(3), JUN(1), LAT(1), LCK(12), MAP2K1(10), MAP2K4(4), MAP3K1(2), MAPK3(1), MAPK8(1), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), NFKB1(7), NFKBIA(2), PIK3CA(8), PIK3R1(3), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(10), PTPN7(2), RAF1(8), RASA1(4), RELA(4), SHC1(1), SOS1(8), SYT1(19), VAV1(15), ZAP70(8)	15798783	222	105	211	100	143	20	9	30	19	1	0.300	1.000	1.000
214	CCR3PATHWAY	CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands.	ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2	21	CCL11(1), CCR3(10), CFL1(1), GNAQ(4), GNAS(19), HRAS(3), LIMK1(4), MAP2K1(10), MAPK1(4), MAPK3(1), MYL2(5), NOX1(11), PIK3C2G(43), PLCB1(48), PPP1R12B(8), PRKCA(10), PTK2(8), RAF1(8), ROCK2(12)	8368659	210	104	191	83	150	7	5	31	17	0	0.0417	1.000	1.000
215	HSA00310_LYSINE_DEGRADATION	Genes involved in lysine degradation	AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE	47	AADAT(5), AASDHPPT(3), AASS(3), ACAT2(1), AKR1B10(8), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), BBOX1(4), DOT1L(8), ECHS1(2), EHHADH(6), EHMT1(7), EHMT2(9), GCDH(5), HADHA(8), HSD17B10(2), HSD17B4(6), HSD3B7(3), NSD1(16), OGDH(11), OGDHL(36), PIPOX(5), PLOD1(5), PLOD2(6), PLOD3(4), RDH11(2), RDH12(2), RDH13(3), SETD1A(23), SETD7(2), SETDB1(10), SHMT1(1), SHMT2(2), SUV39H1(1), SUV39H2(1), TMLHE(1)	19334304	243	104	234	115	157	22	14	33	17	0	0.120	1.000	1.000
216	GLYCINE_SERINE_AND_THREONINE_METABOLISM		ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS	37	ABP1(18), AGXT(10), AGXT2(20), ALAS1(1), ALAS2(5), AMT(1), AOC2(7), AOC3(8), BHMT(8), CBS(6), CHDH(7), CHKA(2), CHKB(3), CPT1B(10), CTH(1), DAO(10), DLD(2), DMGDH(12), GAMT(4), GARS(6), GATM(5), GCAT(4), GLDC(4), MAOA(3), MAOB(13), PEMT(2), PISD(2), PLCB2(9), PLCG1(9), PLCG2(25), PSPH(2), SARDH(19), SARS(10), SHMT1(1), SHMT2(2), TARS(2)	14067327	253	103	243	137	177	17	15	24	20	0	0.107	1.000	1.000
217	HSA00620_PYRUVATE_METABOLISM	Genes involved in pyruvate metabolism	ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2	42	ACACA(21), ACACB(17), ACAT2(1), ACOT12(12), ACSS1(1), ACSS2(4), AKR1B1(2), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(2), LDHA(5), LDHAL6A(4), LDHAL6B(7), LDHB(2), LDHC(5), LDHD(1), MDH1(1), MDH2(4), ME1(19), ME2(1), ME3(9), PC(12), PCK1(23), PCK2(4), PDHA1(3), PDHA2(17), PDHB(1), PKLR(11), PKM2(5)	15671151	233	103	224	124	151	18	15	32	17	0	0.265	1.000	1.000
218	METPATHWAY	The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF.	ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3	34	ACTA1(4), CRK(2), CRKL(2), DOCK1(15), ELK1(2), FOS(2), GAB1(4), GRB2(2), HGF(23), HRAS(3), ITGA1(18), ITGB1(4), JUN(1), MAP2K1(10), MAP2K2(3), MAP4K1(9), MAPK1(4), MAPK3(1), MAPK8(1), MET(19), PAK1(4), PIK3CA(8), PIK3R1(3), PTK2(8), PTK2B(10), PTPN11(9), PXN(3), RAF1(8), RAP1A(2), RAP1B(1), RASA1(4), SOS1(8), SRC(1), STAT3(10)	14338261	208	103	196	103	129	16	7	34	21	1	0.706	1.000	1.000
219	ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY	The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis.	ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP	32	ACTR2(3), ACTR3(2), AKT1(3), ANGPTL2(2), DAG1(5), DGKA(3), ETFA(2), GCA(3), ITGA9(13), ITPKB(7), ITPR1(29), ITPR2(17), ITPR3(6), MAP2K1(10), MAPK1(4), MAPK3(1), NR1I3(7), PAK1(4), PDE3A(24), PDE3B(6), PI3(6), PIK3C2G(43), PIK3CA(8), PIK3CD(7), PIK3R1(3), RIPK3(11), VASP(3)	16198453	232	103	215	93	160	18	10	22	21	1	0.00105	1.000	1.000
220	HIVNEFPATHWAY	HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis.	ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2	52	ACTG1(5), APAF1(6), ARHGDIB(3), BAG4(3), BCL2(2), BIRC2(5), BIRC3(7), CASP2(1), CASP3(2), CASP7(4), CASP8(8), CASP9(3), CFLAR(4), CHUK(2), CRADD(1), CYCS(1), DAXX(9), DFFA(2), DFFB(3), GSN(6), LMNA(8), LMNB1(2), LMNB2(4), MAP2K7(4), MAP3K1(2), MAP3K14(3), MAP3K5(16), MAPK8(1), MDM2(3), NFKB1(7), NFKBIA(2), NUMA1(8), PAK2(8), PRKCD(4), PRKDC(19), PSEN1(1), PSEN2(2), PTK2(8), RASA1(4), RB1(8), RELA(4), RIPK1(1), SPTAN1(7), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF1(6), TRAF2(2)	23135081	218	102	215	100	104	26	14	47	25	2	0.333	1.000	1.000
221	HSA00190_OXIDATIVE_PHOSPHORYLATION	Genes involved in oxidative phosphorylation	ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ	113	ATP12A(24), ATP4A(15), ATP4B(1), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(6), ATP5G2(1), ATP5H(1), ATP5J(2), ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A2(4), ATP6V0A4(19), ATP6V0D2(8), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), COX10(5), COX15(4), COX4I2(4), COX5B(1), COX6A1(1), COX6B1(1), COX6C(1), COX7B(1), COX7B2(2), COX8A(1), COX8C(1), CYC1(4), LHPP(1), NDUFA10(2), NDUFA12(1), NDUFA13(6), NDUFA4(1), NDUFA6(1), NDUFA9(2), NDUFAB1(1), NDUFB2(3), NDUFB3(1), NDUFB5(3), NDUFB6(2), NDUFC2(1), NDUFS2(2), NDUFS3(3), NDUFS4(3), NDUFS5(1), NDUFS6(2), NDUFS7(3), NDUFS8(3), NDUFV1(2), PPA1(1), PPA2(3), SDHA(1), SDHB(1), SDHC(2), SDHD(1), TCIRG1(3), UQCRC1(3), UQCRC2(2), UQCRFS1(2)	18756500	227	102	220	107	135	20	15	35	22	0	0.112	1.000	1.000
222	HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2	Genes involved in glycan structures - biosynthesis 2	A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2	59	A4GALT(5), ABO(6), B3GALNT1(6), B3GALT1(11), B3GALT2(1), B3GALT4(2), B3GALT5(1), B3GNT1(2), B3GNT2(2), B3GNT3(6), B3GNT4(3), B3GNT5(1), B4GALNT1(3), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), B4GALT6(1), FUT1(3), FUT2(3), FUT3(4), FUT4(2), FUT5(6), FUT6(4), FUT7(2), GBGT1(2), PIGA(2), PIGB(4), PIGC(3), PIGF(2), PIGG(10), PIGH(1), PIGK(6), PIGL(2), PIGM(2), PIGN(3), PIGO(12), PIGQ(8), PIGS(1), PIGT(1), PIGU(6), PIGV(7), PIGX(2), PIGZ(3), ST3GAL1(6), ST3GAL2(1), ST3GAL3(1), ST3GAL4(1), ST3GAL5(2), ST3GAL6(2), ST6GALNAC3(5), ST6GALNAC4(1), ST6GALNAC5(7), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(9), UGCG(1)	15943455	199	101	196	114	115	21	11	27	25	0	0.445	1.000	1.000
223	KERATINOCYTEPATHWAY	Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways.	BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2	42	BCL2(2), CHUK(2), DAXX(9), EGF(18), EGFR(22), ETS1(4), ETS2(8), FOS(2), HOXA7(2), HRAS(3), IKBKB(3), JUN(1), MAP2K1(10), MAP2K3(7), MAP2K4(4), MAP2K6(3), MAP2K7(4), MAP3K1(2), MAP3K14(3), MAP3K5(16), MAPK1(4), MAPK13(4), MAPK14(5), MAPK3(1), MAPK8(1), NFKB1(7), NFKBIA(2), PPP2CA(1), PRKCA(10), PRKCD(4), PRKCE(6), PRKCG(13), PRKCH(10), PRKCQ(16), RAF1(8), RELA(4), RIPK1(1), SP1(5), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF2(2)	16355749	236	101	227	147	148	20	9	37	22	0	0.933	1.000	1.000
224	VEGFPATHWAY	Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease.	ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL	25	ARNT(7), EIF2B1(9), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(1), EIF2S1(1), ELAVL1(1), FLT1(33), FLT4(23), HIF1A(5), HRAS(3), KDR(42), NOS3(16), PIK3CA(8), PIK3R1(3), PLCG1(9), PRKCA(10), PTK2(8), PXN(3), SHC1(1), VHL(4)	11418226	192	101	177	98	122	16	3	25	25	1	0.447	1.000	1.000
225	BCRPATHWAY	B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen.	BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1	33	BLNK(12), BTK(15), CALM1(1), CALM2(1), CD79A(2), CD79B(1), ELK1(2), FOS(2), GRB2(2), HRAS(3), JUN(1), LYN(6), MAP2K1(10), MAP3K1(2), MAPK14(5), MAPK3(1), MAPK8(1), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(10), RAF1(8), SHC1(1), SOS1(8), SYK(14), SYT1(19), VAV1(15)	12631923	208	100	197	96	139	10	10	28	21	0	0.313	1.000	1.000
226	HSA00252_ALANINE_AND_ASPARTATE_METABOLISM	Genes involved in alanine and aspartate metabolism	AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB	33	AARS(5), AARS2(2), ABAT(9), ACY3(3), ADSL(6), ADSS(2), ADSSL1(8), AGXT(10), AGXT2(20), ASL(6), ASNS(8), ASPA(3), ASRGL1(3), ASS1(7), CAD(15), CRAT(5), DARS(4), DARS2(3), DDO(7), DLAT(2), DLD(2), GAD1(13), GAD2(7), GOT1(6), GOT2(5), GPT(3), GPT2(1), NARS(2), NARS2(5), PC(12), PDHA1(3), PDHA2(17), PDHB(1)	12689366	205	100	195	98	145	19	10	21	10	0	0.0460	1.000	1.000
227	HSA00330_ARGININE_AND_PROLINE_METABOLISM	Genes involved in arginine and proline metabolism	ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2	34	ALDH4A1(6), ARG1(1), ARG2(1), ASL(6), ASS1(7), CKM(2), CKMT1A(1), CKMT2(5), CPS1(21), DAO(10), EPRS(9), GAMT(4), GATM(5), GLUD1(2), GLUD2(4), GOT1(6), GOT2(5), LAP3(1), NOS1(58), NOS3(16), OAT(3), OTC(4), P4HA1(9), P4HA2(4), P4HA3(12), PRODH(1), PYCR1(1), PYCR2(1), RARS(7), RARS2(2)	11969795	214	100	204	119	146	22	8	17	21	0	0.314	1.000	1.000
228	HSA00790_FOLATE_BIOSYNTHESIS	Genes involved in folate biosynthesis	ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR	41	ALPI(8), ALPL(9), ALPP(9), ALPPL2(11), ASCC3(10), ATP13A2(9), DDX18(4), DDX19A(1), DDX23(5), DDX4(11), DDX41(6), DDX47(1), DDX50(4), DDX51(5), DDX52(3), DDX54(2), DDX55(3), DDX56(3), DHX58(4), ENTPD7(2), EP400(22), ERCC2(2), ERCC3(4), FPGS(3), GGH(2), IFIH1(13), MOV10L1(26), NUDT5(2), NUDT8(1), QDPR(3), RAD54B(6), RUVBL2(4), SETX(17), SKIV2L2(4), SMARCA2(11), SMARCA5(5), SPR(2)	20864780	237	100	226	132	153	15	12	31	26	0	0.700	1.000	1.000
229	NUCLEAR_RECEPTORS		ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR	40	ALK(27), AR(7), ESR1(5), ESR2(6), ESRRA(2), HNF4A(18), NPM1(3), NR0B1(2), NR1D2(9), NR1H2(3), NR1H3(3), NR1I2(3), NR1I3(7), NR2C2(2), NR2E1(4), NR2F1(8), NR2F2(1), NR2F6(1), NR3C1(7), NR4A1(3), NR4A2(3), NR5A1(7), NR5A2(18), PGR(15), PPARA(6), PPARD(3), PPARG(11), RARA(3), RARB(5), RARG(2), ROR1(10), RORA(4), RORC(7), RXRA(4), RXRB(4), RXRG(5), THRA(2), THRB(14), VDR(2)	13923535	246	100	236	126	180	19	4	24	19	0	0.0944	1.000	1.000
230	HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM	Genes involved in glycine, serine and threonine metabolism	ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2	44	ABP1(18), AGXT(10), AGXT2(20), AKR1B10(8), ALAS1(1), ALAS2(5), AMT(1), AOC2(7), AOC3(8), BHMT(8), CBS(6), CHDH(7), CHKA(2), CHKB(3), CTH(1), DAO(10), DLD(2), DMGDH(12), GAMT(4), GARS(6), GATM(5), GCAT(4), GLDC(4), GNMT(1), HSD3B7(3), MAOA(3), MAOB(13), PEMT(2), PIPOX(5), PISD(2), PSAT1(2), PSPH(2), RDH11(2), RDH12(2), RDH13(3), SARDH(19), SARS(10), SARS2(3), SDS(2), SHMT1(1), SHMT2(2), TARS(2), TARS2(7)	13924445	238	99	229	135	167	17	13	17	24	0	0.258	1.000	1.000
231	HSA00340_HISTIDINE_METABOLISM	Genes involved in histidine metabolism	ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22	41	ABP1(18), ACY3(3), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH7A1(9), ALDH9A1(2), AMDHD1(4), AOC2(7), AOC3(8), ASPA(3), CARM1(6), CNDP1(8), DDC(12), FTCD(2), HAL(12), HARS(6), HARS2(4), HDC(19), HEMK1(4), HNMT(1), LCMT1(4), MAOA(3), MAOB(13), METTL2B(7), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), PRPS1(2), PRPS2(3), UROC1(11), WBSCR22(1)	13210690	228	99	222	147	150	24	14	21	19	0	0.666	1.000	1.000
232	MONOAMINE_GPCRS		ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164	32	ADRA1A(8), ADRA1B(3), ADRA1D(4), ADRA2A(3), ADRA2C(2), ADRB1(5), ADRB2(2), CHRM1(5), CHRM2(18), CHRM3(19), CHRM4(6), CHRM5(4), DRD1(8), DRD2(15), DRD3(5), DRD4(1), DRD5(22), HRH1(14), HRH2(3), HTR1A(8), HTR1B(1), HTR1D(3), HTR1E(5), HTR1F(7), HTR2A(8), HTR2B(2), HTR2C(10), HTR4(9), HTR5A(16), HTR6(1), HTR7(8)	8419362	225	99	209	173	147	25	7	25	21	0	0.123	1.000	1.000
233	PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM		AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO	31	AKR1C3(9), ALOX12(5), ALOX15(8), ALOX5(8), CBR3(1), CYP4F2(12), CYP4F3(19), EPX(7), GGT1(6), LPO(18), LTA4H(4), MPO(11), PLA2G1B(1), PLA2G2A(2), PLA2G2E(4), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PRDX1(2), PRDX2(2), PRDX6(4), PTGDS(2), PTGES2(1), PTGIS(12), PTGS1(17), PTGS2(10), TBXAS1(11), TPO(40)	9318845	253	99	247	149	192	22	3	19	17	0	0.0899	1.000	1.000
234	CLASSICPATHWAY	The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response.	C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9	9	C1QA(4), C1QB(3), C1R(13), C1S(15), C3(46), C5(14), C6(56), C7(43), C9(19)	4844607	213	98	192	95	162	9	5	19	17	1	0.0631	1.000	1.000
235	HSA04740_OLFACTORY_TRANSDUCTION	Genes involved in olfactory transduction	ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY	30	ADCY3(3), ADRBK2(4), ARRB2(6), CALM1(1), CALM2(1), CALML3(6), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CLCA1(6), CLCA2(9), CLCA4(26), CNGA3(24), CNGA4(14), CNGB1(20), GNAL(2), GUCA1A(5), GUCA1B(2), GUCA1C(6), PDC(5), PDE1C(41), PRKACA(3), PRKACB(4), PRKACG(8), PRKG1(12), PRKG2(13), PRKX(3)	10082431	242	98	229	141	168	20	7	28	19	0	0.396	1.000	1.000
236	HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS	Genes involved in aminoacyl-tRNA biosynthesis	AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2	38	AARS(5), AARS2(2), CARS(9), CARS2(2), DARS(4), DARS2(3), EPRS(9), FARS2(4), FARSA(6), FARSB(5), GARS(6), HARS(6), HARS2(4), IARS(8), IARS2(13), KARS(4), LARS(10), LARS2(4), MARS(6), MARS2(4), MTFMT(2), NARS(2), NARS2(5), QARS(6), RARS(7), RARS2(2), SARS(10), SARS2(3), TARS(2), TARS2(7), VARS(18), VARS2(6), WARS(4), WARS2(4), YARS(1), YARS2(2)	18319729	195	97	182	97	119	21	9	25	21	0	0.385	1.000	1.000
237	TOLLPATHWAY	Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB.	CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6	31	CD14(5), CHUK(2), ELK1(2), FOS(2), IKBKB(3), IRAK1(4), JUN(1), LY96(4), MAP2K3(7), MAP2K4(4), MAP2K6(3), MAP3K1(2), MAP3K14(3), MAP3K7(1), MAPK14(5), MAPK8(1), MYD88(3), NFKB1(7), NFKBIA(2), PPARA(6), RELA(4), TIRAP(1), TLR10(11), TLR2(15), TLR3(9), TLR4(31), TLR6(5), TLR7(15), TLR9(14), TOLLIP(1), TRAF6(4)	12116932	177	97	174	88	114	17	9	23	14	0	0.261	1.000	1.000
238	HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION	Genes involved in valine, leucine and isoleucine degradation	ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB	44	ABAT(9), ACAA1(5), ACAA2(1), ACADM(5), ACADS(4), ACAT2(1), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH6A1(3), ALDH7A1(9), ALDH9A1(2), AOX1(21), AUH(3), BCAT1(11), BCAT2(1), BCKDHA(1), BCKDHB(2), DBT(1), DLD(2), ECHS1(2), EHHADH(6), HADHA(8), HADHB(4), HIBADH(8), HIBCH(1), HMGCL(4), HMGCS1(2), HMGCS2(17), HSD17B10(2), HSD17B4(6), IVD(4), MCCC1(5), MCCC2(2), MCEE(2), MUT(5), OXCT1(4), OXCT2(3), PCCA(3), PCCB(2)	14450538	192	96	184	95	119	19	12	29	13	0	0.459	1.000	1.000
239	PYRUVATE_METABOLISM		ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2	37	ACACA(21), ACAT2(1), ADH5(3), AKR1B1(2), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2), DLAT(2), DLD(2), GLO1(1), GRHPR(2), HAGH(2), LDHA(5), LDHB(2), LDHC(5), LDHD(1), MDH1(1), MDH2(4), ME1(19), ME2(1), ME3(9), PC(12), PCK1(23), PDHA1(3), PDHA2(17), PDHB(1), PKLR(11), PKM2(5)	12386901	193	96	187	105	131	16	10	24	12	0	0.423	1.000	1.000
240	ST_GA12_PATHWAY	G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK.	BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1	22	BTK(15), DLG4(4), EPHB2(29), F2(9), F2RL1(15), F2RL2(6), F2RL3(3), JUN(1), MAP2K5(3), MAPK1(4), MAPK7(4), MAPK8(1), MYEF2(4), PLD1(11), PLD2(5), PLD3(1), PTK2(8), RAF1(8), RASAL1(15), SRC(1), TEC(10), VAV1(15)	9149425	172	96	164	106	97	18	6	35	16	0	0.854	1.000	1.000
241	INTEGRINPATHWAY	Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX	35	ACTA1(4), ACTN1(5), ACTN2(21), ACTN3(7), BCAR1(4), BCR(10), CAPN1(4), CAPNS1(1), CAV1(1), CRKL(2), CSK(1), FYN(6), GRB2(2), HRAS(3), ITGA1(18), ITGB1(4), JUN(1), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), MAPK8(1), PPP1R12B(8), PTK2(8), PXN(3), RAF1(8), RAP1A(2), ROCK1(5), SHC1(1), SOS1(8), SRC(1), TLN1(12), VCL(7), ZYX(6)	15599260	182	95	174	90	104	20	8	29	20	1	0.256	1.000	1.000
242	ALTERNATIVEPATHWAY	The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex.	BF, C3, C5, C6, C7, C8A, C9, DF, PFC	5	C3(46), C5(14), C6(56), C7(43), C9(19)	3766498	178	94	157	76	136	5	4	17	15	1	0.0572	1.000	1.000
243	HSA00360_PHENYLALANINE_METABOLISM	Genes involved in phenylalanine metabolism	ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO	27	ABP1(18), ALDH1A3(2), ALDH3A1(5), ALDH3B1(2), ALDH3B2(7), AOC2(7), AOC3(8), DDC(12), EPX(7), ESCO1(1), ESCO2(2), GOT1(6), GOT2(5), HPD(5), LPO(18), MAOA(3), MAOB(13), MPO(11), MYST3(15), MYST4(14), NAT6(2), PNPLA3(2), PRDX6(4), SH3GLB1(2), TAT(17), TPO(40)	11460378	228	94	222	146	167	21	10	17	13	0	0.744	1.000	1.000
244	HSA00600_SPHINGOLIPID_METABOLISM	Genes involved in sphingolipid metabolism	ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8	36	ARSD(3), ARSE(5), B4GALT6(1), CERK(1), DEGS1(1), DEGS2(4), ENPP7(6), GAL3ST1(8), GALC(3), GBA(3), GLA(1), GLB1(8), LCT(40), NEU1(7), NEU2(14), NEU3(3), NEU4(9), PPAP2B(6), PPAP2C(8), SGMS1(15), SGMS2(1), SGPP2(6), SMPD1(3), SMPD2(1), SMPD3(8), SMPD4(5), SPHK1(1), SPHK2(7), SPTLC1(1), SPTLC2(6), UGCG(1), UGT8(7)	11837746	193	94	187	123	136	14	5	23	15	0	0.757	1.000	1.000
245	RAC1PATHWAY	Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia.	ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1	21	ARFIP2(1), CDK5(4), CFL1(1), CHN1(5), LIMK1(4), MAP3K1(2), MYL2(5), MYLK(39), NCF2(7), PAK1(4), PDGFRA(27), PIK3CA(8), PIK3R1(3), PLD1(11), PPP1R12B(8), RALBP1(2), RPS6KB1(2), TRIO(18), VAV1(15), WASF1(4)	11572854	170	94	163	100	112	10	9	21	17	1	0.840	1.000	1.000
246	SPPAPATHWAY	Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin.	F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1	21	F2(9), F2R(6), F2RL3(3), GNAI1(1), HRAS(3), ITGA1(18), ITGB1(4), MAP2K1(10), MAPK1(4), MAPK3(1), PLA2G4A(11), PLCB1(48), PRKCA(10), PTGS1(17), PTK2(8), RAF1(8), SRC(1), SYK(14), TBXAS1(11)	8136189	187	94	173	87	131	13	5	20	18	0	0.131	1.000	1.000
247	VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION		ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS	36	ACAA1(5), ACAA2(1), ACADL(4), ACADM(5), ACADS(4), ACADSB(6), ACAT2(1), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH6A1(3), ALDH9A1(2), AOX1(21), BCAT1(11), BCKDHA(1), BCKDHB(2), ECHS1(2), EHHADH(6), HADHA(8), HADHB(4), HIBADH(8), HMGCL(4), IVD(4), MCCC1(5), MCCC2(2), MCEE(2), MUT(5), OXCT1(4), PCCA(3), PCCB(2), SDS(2)	12098840	163	94	157	83	103	15	8	23	14	0	0.526	1.000	1.000
248	ALKPATHWAY	Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development.	ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1	32	ACVR1(2), APC(19), ATF2(5), AXIN1(10), BMP10(13), BMP2(4), BMP4(3), BMP5(25), BMP7(2), BMPR1A(2), BMPR2(5), CHRD(14), CTNNB1(11), FZD1(4), GATA4(2), GSK3B(2), MAP3K7(1), MEF2C(2), MYL2(5), NKX2-5(1), NOG(1), NPPA(3), NPPB(5), RFC1(5), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(8), TGFBR3(6), WNT1(2)	12084133	167	93	158	84	111	15	6	16	19	0	0.609	1.000	1.000
249	ERKPATHWAY	Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway.	DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3	29	DPM2(1), EGFR(22), ELK1(2), GNAS(19), GRB2(2), HRAS(3), IGF1R(10), ITGB1(4), KLK2(2), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), MKNK1(5), MKNK2(2), MYC(5), NGFR(7), PDGFRA(27), PPP2CA(1), PTPRR(24), RAF1(8), RPS6KA1(6), RPS6KA5(4), SHC1(1), SOS1(8), SRC(1), STAT3(10)	10987139	192	93	182	99	124	17	9	29	13	0	0.452	1.000	1.000
250	GSK3PATHWAY	Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus.	AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1	26	AKT1(3), APC(19), AXIN1(10), CCND1(1), CD14(5), CTNNB1(11), FZD1(4), GJA1(7), GNAI1(1), GSK3B(2), IRAK1(4), LBP(8), LEF1(3), LY96(4), MYD88(3), NFKB1(7), PDPK1(4), PIK3CA(8), PIK3R1(3), PPP2CA(1), RELA(4), TIRAP(1), TLR4(31), TOLLIP(1), WNT1(2)	10153763	147	93	142	74	89	11	9	19	18	1	0.576	1.000	1.000
251	HSA00510_N_GLYCAN_BIOSYNTHESIS	Genes involved in N-glycan biosynthesis	ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B	41	ALG1(2), ALG10(4), ALG10B(4), ALG12(1), ALG13(8), ALG14(2), ALG2(4), ALG3(4), ALG5(2), ALG6(2), ALG8(6), ALG9(5), B4GALT1(2), B4GALT2(2), B4GALT3(2), DAD1(1), DDOST(2), DHDDS(1), DOLPP1(3), DPAGT1(2), DPM1(1), FUT8(8), GANAB(5), MAN1A1(15), MAN1A2(4), MAN1B1(4), MAN1C1(7), MAN2A1(10), MGAT1(3), MGAT2(2), MGAT3(10), MGAT4A(8), MGAT4B(1), MGAT5(4), MGAT5B(9), RFT1(3), RPN2(2), ST6GAL1(5), STT3B(5)	14155561	165	93	161	90	100	17	11	18	19	0	0.426	1.000	1.000
252	RHOPATHWAY	RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains.	ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL	30	ACTR2(3), ACTR3(2), ARHGAP1(2), ARHGAP4(2), ARHGAP5(11), ARHGAP6(11), ARHGEF1(1), ARHGEF11(17), ARHGEF5(15), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), BAIAP2(5), CFL1(1), DIAPH1(6), GSN(6), LIMK1(4), MYL2(5), MYLK(39), OPHN1(4), PIP5K1A(6), PIP5K1B(18), PPP1R12B(8), ROCK1(5), SRC(1), TLN1(12), VCL(7)	15047378	197	93	190	94	138	13	7	25	14	0	0.0703	1.000	1.000
253	SA_B_CELL_RECEPTOR_COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.	ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3	23	ATF2(5), BCR(10), BLNK(12), ELK1(2), FOS(2), GRB2(2), HRAS(3), JUN(1), LYN(6), MAP2K1(10), MAP3K1(2), MAPK1(4), MAPK3(1), MAPK8IP3(8), PAPPA(50), RPS6KA1(6), RPS6KA3(2), SHC1(1), SOS1(8), SYK(14), VAV1(15), VAV2(3), VAV3(9)	10492583	176	93	164	112	125	12	3	18	17	1	0.898	1.000	1.000
254	GPCRPATHWAY	G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways.	ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1	34	ADCY1(26), CALM1(1), CALM2(1), ELK1(2), FOS(2), GNAI1(1), GNAQ(4), GNAS(19), HRAS(3), JUN(1), MAP2K1(10), MAPK3(1), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), RAF1(8), RPS6KA3(2), SYT1(19)	11605364	198	92	186	113	131	15	10	23	19	0	0.777	1.000	1.000
255	BLYMPHOCYTEPATHWAY	B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface.	CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5	10	CD80(4), CR1(53), CR2(32), FCGR2B(3), HLA-DRA(11), HLA-DRB1(3), ICAM1(2), ITGAL(24), ITGB2(13), PTPRC(30)	5023253	175	91	168	68	116	15	5	15	24	0	0.0339	1.000	1.000
256	SPRYPATHWAY	Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation.	CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC	18	CBL(8), EGF(18), EGFR(22), GRB2(2), HRAS(3), MAP2K1(10), MAPK1(4), MAPK3(1), PTPRB(79), RAF1(8), RASA1(4), SHC1(1), SOS1(8), SPRY1(7), SPRY2(4), SPRY3(11), SPRY4(1), SRC(1)	8348128	192	91	176	86	137	16	6	19	14	0	0.271	1.000	1.000
257	APOPTOSIS_KEGG		APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6	47	APAF1(6), BAX(3), BCL2(2), BCL2A1(1), BCL2L2(2), CASP1(4), CASP10(4), CASP2(1), CASP3(2), CASP4(1), CASP7(4), CASP8(8), CASP9(3), CD40(4), CD40LG(2), CRADD(1), CYCS(1), DAXX(9), DFFA(2), DFFB(3), FAS(5), FASLG(14), IKBKE(9), LTA(2), MCL1(3), NFKB1(7), NFKBIA(2), NGFR(7), NR3C1(7), NTRK1(15), PTPN13(12), RIPK1(1), SFRS2IP(7), TFG(2), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF1(6), TRAF2(2), TRAF3(5), TRAF6(4)	14484803	180	90	179	99	113	15	9	22	21	0	0.757	1.000	1.000
258	PHENYLALANINE_METABOLISM		ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO	22	ABP1(18), ALDH1A3(2), ALDH3A1(5), ALDH3B1(2), ALDH3B2(7), AOC2(7), AOC3(8), DDC(12), EPX(7), GOT1(6), GOT2(5), HPD(5), LPO(18), MAOA(3), MAOB(13), MPO(11), PRDX1(2), PRDX2(2), PRDX6(4), TAT(17), TPO(40)	7324905	194	90	189	118	147	17	9	10	11	0	0.148	1.000	1.000
259	PROSTAGLANDIN_SYNTHESIS_REGULATION		ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1	27	ANXA1(4), ANXA2(2), ANXA3(4), ANXA4(2), ANXA5(1), ANXA6(6), CYP11A1(13), EDN1(8), EDNRA(8), EDNRB(4), HPGD(1), HSD11B1(11), HSD11B2(2), PLA2G4A(11), PRL(1), PTGDR(9), PTGDS(2), PTGER2(6), PTGER4(1), PTGFR(20), PTGIR(5), PTGIS(12), PTGS1(17), PTGS2(10), S100A6(1), SCGB1A1(1), TBXAS1(11)	6837460	173	90	165	73	122	17	3	15	16	0	0.00135	1.000	1.000
260	CXCR4PATHWAY	CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis.	BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA	23	BCAR1(4), CRK(2), CXCL12(2), CXCR4(3), GNAI1(1), GNAQ(4), HRAS(3), MAP2K1(10), MAPK1(4), MAPK3(1), NFKB1(7), PIK3C2G(43), PIK3CA(8), PIK3R1(3), PLCG1(9), PRKCA(10), PTK2(8), PTK2B(10), PXN(3), RAF1(8), RELA(4)	9181105	147	89	134	74	97	9	3	24	13	1	0.464	1.000	1.000
261	HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION	Genes involved in 1- and 2-methylnaphthalene degradation	ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	22	ACAD8(1), ACAD9(1), ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), DHRS1(3), DHRS2(6), DHRS3(4), DHRS7(1), DHRSX(4), ESCO1(1), ESCO2(2), MYST3(15), MYST4(14), NAT6(2), PNPLA3(2), SH3GLB1(2)	8392947	169	89	150	75	119	15	6	22	7	0	0.223	1.000	1.000
262	HSA05110_CHOLERA_INFECTION	Genes involved in cholera - infection	ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23	41	ACTG1(5), ACTG2(4), ADCY3(3), ADCY9(9), AK1(1), ARF4(3), ARF5(1), ARL4D(2), ATP6V0A1(9), ATP6V0A2(4), ATP6V0A4(19), ATP6V0D2(8), ATP6V0E1(1), ATP6V1A(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1E2(3), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), ERO1L(5), GNAS(19), PDIA4(4), PLCG1(9), PLCG2(25), PRKCA(10), SEC61A1(2), SEC61A2(7), TRIM23(2)	12409914	180	89	174	115	121	8	9	24	18	0	0.700	1.000	1.000
263	TRANSLATION_FACTORS		ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1	37	EEF1A2(10), EEF1B2(4), EEF1D(1), EEF1G(1), EEF2(2), EEF2K(5), EIF1AX(3), EIF2AK1(3), EIF2AK2(5), EIF2AK3(17), EIF2B1(9), EIF2B2(1), EIF2B3(3), EIF2B4(1), EIF2B5(1), EIF2S1(1), EIF4A1(3), EIF4A2(3), EIF4EBP1(1), EIF4G1(13), EIF4G3(17), EIF5(1), EIF5B(2), ETF1(2), GSPT2(8), KIAA0664(4), PABPC1(5), PABPC3(9), PAIP1(7), SLC35A4(4)	14601616	146	89	135	78	70	13	12	22	29	0	0.907	1.000	1.000
264	GHPATHWAY	Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase.	GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1	25	GH1(3), GHR(25), GRB2(2), HRAS(3), INSR(20), IRS1(5), JAK2(9), MAP2K1(10), MAPK1(4), MAPK3(1), PIK3CA(8), PIK3R1(3), PLCG1(9), PRKCA(10), PTPN6(3), RAF1(8), RPS6KA1(6), SHC1(1), SLC2A4(8), SOS1(8), SRF(2), STAT5A(2), STAT5B(4)	11091876	154	88	144	83	93	13	7	26	14	1	0.664	1.000	1.000
265	GPCRDB_CLASS_B_SECRETIN_LIKE		ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2	20	ADCYAP1R1(16), CALCR(15), CALCRL(14), CD97(6), CRHR1(6), CRHR2(2), ELTD1(23), EMR1(27), EMR2(4), GHRHR(4), GIPR(2), GLP1R(11), GLP2R(14), GPR64(5), LPHN1(6), LPHN2(34), LPHN3(20), SCTR(7), VIPR1(4), VIPR2(5)	8798714	225	88	210	145	163	15	12	16	19	0	0.345	1.000	1.000
266	HSA00903_LIMONENE_AND_PINENE_DEGRADATION	Genes involved in limonene and pinene degradation	ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	26	ACOT11(6), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), CYP2C19(35), CYP2C9(35), DHRS1(3), DHRS2(6), DHRS3(4), DHRS7(1), DHRSX(4), ECHS1(2), EHHADH(6), ESCO1(1), ESCO2(2), HADHA(8), MYST3(15), MYST4(14), NAT6(2), PNPLA3(2), SH3GLB1(2), YOD1(1)	10382642	181	88	169	122	120	18	9	21	13	0	0.971	1.000	1.000
267	ST_GAQ_PATHWAY	G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity.	ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1	26	ADRBK1(5), AKT1(3), AKT2(8), AKT3(4), DAG1(5), GNAQ(4), ITPKB(7), ITPR1(29), ITPR2(17), ITPR3(6), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PDK1(2), PHKA2(7), PIK3CB(21), PITX2(4), PLD1(11), PLD2(5), PLD3(1)	14967109	160	88	152	100	78	17	13	32	20	0	0.805	1.000	1.000
268	ST_INTERLEUKIN_4_PATHWAY	Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2	26	AKT1(3), AKT2(8), AKT3(4), CISH(3), GRB2(2), IARS(8), IL13RA1(3), IL2RG(3), IL4(1), IL4R(13), INPP5D(31), JAK1(6), JAK2(9), JAK3(6), NR0B2(6), PI3(6), PIK3CA(8), PPP1R13B(6), RPS6KB1(2), SERPINA4(14), SHC1(1), SOS1(8), SOS2(11), SRC(1), STAT6(7), TYK2(7)	12308248	177	88	171	85	116	11	9	24	17	0	0.390	1.000	1.000
269	AT1RPATHWAY	Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway.	AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	32	AGT(5), AGTR1(10), ATF2(5), CALM1(1), CALM2(1), EGFR(22), ELK1(2), GNAQ(4), GRB2(2), HRAS(3), JUN(1), MAP2K1(10), MAP2K2(3), MAP2K4(4), MAP3K1(2), MAPK1(4), MAPK3(1), MAPK8(1), MEF2A(5), MEF2B(2), MEF2C(2), MEF2D(4), PAK1(4), PRKCA(10), PTK2(8), PTK2B(10), RAF1(8), SHC1(1), SOS1(8), SRC(1), SYT1(19)	11028980	163	87	149	94	106	12	7	22	16	0	0.889	1.000	1.000
270	ECMPATHWAY	Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization.	ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1	22	ARHGAP5(11), DIAPH1(6), FYN(6), GSN(6), HRAS(3), ITGA1(18), ITGB1(4), MAP2K1(10), MAPK1(4), MAPK3(1), MYL2(5), MYLK(39), PIK3CA(8), PIK3R1(3), PTK2(8), PXN(3), RAF1(8), ROCK1(5), SHC1(1), SRC(1), TLN1(12)	12476976	162	87	149	77	106	12	5	25	13	1	0.322	1.000	1.000
271	EDG1PATHWAY	The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation.	ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC	21	ADCY1(26), AKT1(3), GNAI1(1), ITGAV(9), ITGB3(11), MAPK1(4), MAPK3(1), PDGFA(1), PDGFRA(27), PIK3CA(8), PIK3R1(3), PLCB1(48), PRKCA(10), PTK2(8), SMPD1(3), SMPD2(1), SPHK1(1), SRC(1)	9068809	166	87	159	78	117	8	6	19	15	1	0.121	1.000	1.000
272	HSA04614_RENIN_ANGIOTENSIN_SYSTEM	Genes involved in renin-angiotensin system	ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1	17	ACE(34), ACE2(7), AGT(5), AGTR1(10), AGTR2(9), ANPEP(17), CMA1(5), CPA3(18), CTSA(4), CTSG(4), ENPEP(32), LNPEP(10), MAS1(3), MME(19), NLN(4), REN(9), THOP1(7)	7039142	197	87	187	101	139	17	12	12	17	0	0.0610	1.000	1.000
273	MONOCYTEPATHWAY	Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins.	CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP	11	CD44(5), ICAM1(2), ITGA4(36), ITGAL(24), ITGAM(21), ITGB1(4), ITGB2(13), SELE(34), SELL(8), SELP(30)	5272867	177	87	168	57	135	4	5	14	19	0	0.000338	1.000	1.000
274	ST_WNT_CA2_CYCLIC_GMP_PATHWAY	Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP.	BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF	19	CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), DAG1(5), ITPKB(7), ITPR1(29), ITPR2(17), ITPR3(6), NFAT5(7), PDE6A(11), PDE6B(13), PDE6C(23), PDE6D(2), PDE6G(2), SLC6A13(25), TF(11)	11911801	176	87	165	110	124	10	6	15	21	0	0.423	1.000	1.000
275	HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION	Genes involved in gamma-hexachlorocyclohexane degradation	ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3	23	ACP1(3), ACP2(2), ACP5(3), ACP6(11), ACPP(8), ALPI(8), ALPL(9), ALPP(9), ALPPL2(11), CMBL(4), CYP3A4(19), CYP3A43(15), CYP3A5(10), CYP3A7(18), DHRS1(3), DHRS2(6), DHRS3(4), DHRS7(1), DHRSX(4), PON1(14), PON2(1), PON3(5)	6005264	168	86	159	54	124	11	7	11	15	0	6.23e-06	1.000	1.000
276	HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS	Genes involved in heparan sulfate biosynthesis	EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4	19	EXT1(2), EXT2(6), EXTL1(2), EXTL3(10), GLCE(8), HS2ST1(1), HS3ST1(10), HS3ST2(7), HS3ST3A1(4), HS3ST3B1(2), HS3ST5(8), HS6ST1(3), HS6ST2(2), HS6ST3(12), NDST1(4), NDST2(2), NDST3(23), NDST4(45)	6796761	151	86	146	81	98	11	5	19	18	0	0.267	1.000	1.000
277	HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION	Genes involved in 3-chloroacrylic acid degradation	ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1	15	ADH1A(14), ADH1B(27), ADH1C(27), ADH4(11), ADH5(3), ADH6(11), ADH7(13), ADHFE1(5), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2)	4427039	143	86	123	53	101	14	9	13	6	0	0.00217	1.000	1.000
278	HSA01032_GLYCAN_STRUCTURES_DEGRADATION	Genes involved in degradation of glycan structures	AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1	29	AGA(4), ARSB(1), FUCA1(2), GALNS(4), GBA(3), GLB1(8), GNS(2), GUSB(3), HEXA(5), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(4), HYAL1(2), HYAL2(1), IDS(9), IDUA(4), LCT(40), MAN2B1(7), MAN2B2(8), MAN2C1(3), MANBA(7), NAGLU(4), NEU1(7), NEU2(14), NEU3(3), NEU4(9), SPAM1(20)	11407574	193	86	190	98	138	15	5	19	16	0	0.169	1.000	1.000
279	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM		ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS	25	ALAD(5), BLVRA(2), BLVRB(1), CP(11), CPOX(4), EPRS(9), FECH(3), GUSB(3), HCCS(2), HMBS(1), HMOX1(1), HMOX2(1), PPOX(3), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(8), UGT1A9(10), UGT2B4(31), UROS(1)	8556760	159	86	150	76	106	16	12	10	14	1	0.159	1.000	1.000
280	ST_P38_MAPK_PATHWAY	p38 is a MAP kinase regulated by cytokines and cellular stress.	AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6	35	AKT1(3), ATF1(4), CDC42(2), CREB3(1), CREB5(9), DUSP10(6), EEF2K(5), ELK1(2), HSPB1(2), IL1R1(11), MAP2K3(7), MAP2K4(4), MAP2K6(3), MAP3K10(8), MAP3K4(17), MAP3K5(16), MAP3K7(1), MAPK1(4), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPKAPK2(7), MAPKAPK5(1), MKNK1(5), MKNK2(2), MYEF2(4), NFKB1(7), NR2C2(2), SRF(2), TRAF6(4)	11124546	150	86	145	81	95	12	3	23	17	0	0.641	1.000	1.000
281	ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY	The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement.	A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ	31	A1BG(2), AKT1(3), AKT2(8), AKT3(4), BTK(15), DAPP1(5), GRB2(2), GSK3B(2), IARS(8), IGFBP1(3), INPP5D(31), PDK1(2), PIK3CA(8), PPP1R13B(6), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), RPS6KB1(2), SFN(1), SHC1(1), SOS1(8), SOS2(11), TEC(10), YWHAB(1), YWHAE(1), YWHAG(1), YWHAQ(3)	11579819	153	86	145	59	96	11	11	21	14	0	0.0801	1.000	1.000
282	CARM_ERPATHWAY	Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1.	BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP	25	BRCA1(9), CARM1(6), CCND1(1), CREBBP(20), EP300(14), ERCC3(4), ESR1(5), GRIP1(9), GTF2A1(2), GTF2E1(2), GTF2F1(5), HDAC1(1), HDAC2(1), HDAC3(5), HDAC4(10), HDAC5(6), HDAC6(2), MEF2C(2), NCOR2(24), NR0B1(2), NRIP1(8), PELP1(11), POLR2A(11), TBP(4)	15184305	164	85	163	84	111	6	12	24	11	0	0.597	1.000	1.000
283	HSA00640_PROPANOATE_METABOLISM	Genes involved in propanoate metabolism	ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2	33	ABAT(9), ACACA(21), ACACB(17), ACADM(5), ACAT2(1), ACSS1(1), ACSS2(4), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH6A1(3), ALDH7A1(9), ALDH9A1(2), ECHS1(2), EHHADH(6), HADHA(8), HIBCH(1), LDHA(5), LDHAL6A(4), LDHAL6B(7), LDHB(2), LDHC(5), MCEE(2), MLYCD(2), MUT(5), PCCA(3), PCCB(2), SUCLG1(2), SUCLG2(2)	13332782	151	85	145	82	88	14	14	25	10	0	0.597	1.000	1.000
284	MCALPAINPATHWAY	In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins.	ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2	24	ACTA1(4), CAPN1(4), CAPN2(6), CAPNS1(1), CXCR3(4), EGF(18), EGFR(22), HRAS(3), ITGA1(18), ITGB1(4), MAPK1(4), MAPK3(1), MYL2(5), MYLK(39), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PTK2(8), PXN(3), TLN1(12)	10849171	178	85	172	106	125	11	8	19	15	0	0.536	1.000	1.000
285	APOPTOSIS_GENMAPP		APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2	40	APAF1(6), BAX(3), BCL2(2), BIRC2(5), BIRC3(7), CASP2(1), CASP3(2), CASP7(4), CASP8(8), CASP9(3), CYCS(1), FAS(5), FASLG(14), GZMB(3), JUN(1), MAP2K4(4), MAP3K1(2), MAP3K14(3), MAPK10(8), MCL1(3), MDM2(3), MYC(5), NFKB1(7), NFKBIA(2), PARP1(8), PRF1(11), RELA(4), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TNFSF10(7), TRAF1(6), TRAF2(2)	12176215	148	84	148	68	88	17	11	17	15	0	0.258	1.000	1.000
286	CIRCADIAN_EXERCISE		ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR	40	ARNTL(6), AZIN1(1), BTG1(2), CBX3(1), CLOCK(4), CRY1(7), CRY2(3), DAZAP2(1), DNAJA1(1), EIF4G2(5), ETV6(11), GFRA1(8), GSTM3(4), GSTP1(2), HERPUD1(2), HSPA8(5), IDI1(1), KLF9(2), MYF6(12), NCKAP1(5), NCOA4(4), NR1D2(9), PER1(8), PER2(11), PIGF(2), PPP1R3C(3), PPP2CB(2), PSMA4(1), PURA(3), SF3A3(4), TOB1(2), TUBB3(5), UCP3(4), UGP2(1), VAPA(1), ZFR(8)	12209248	151	84	149	67	72	14	12	32	21	0	0.652	1.000	1.000
287	HDACPATHWAY	Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases.	AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH	30	AKT1(3), CABIN1(9), CALM1(1), CALM2(1), CAMK1(4), CAMK1G(9), HDAC5(6), IGF1(11), IGF1R(10), INSR(20), MAP2K6(3), MAPK14(5), MAPK7(4), MEF2A(5), MEF2B(2), MEF2C(2), MEF2D(4), MYOD1(1), NFATC1(15), NFATC2(9), PIK3CA(8), PIK3R1(3), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYT1(19)	11648624	165	84	157	87	110	15	5	23	11	1	0.368	1.000	1.000
288	HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS	Genes involved in urea cycle and metabolism of amino groups	ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM	30	ABP1(18), ACY1(1), ADC(5), AGMAT(3), ALDH18A1(7), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), AOC2(7), AOC3(8), ARG1(1), ARG2(1), ASL(6), ASS1(7), CPS1(21), GATM(5), MAOA(3), MAOB(13), NAGS(1), ODC1(3), OTC(4), SAT2(1), SMS(5)	9753586	152	84	147	93	91	16	12	17	16	0	0.619	1.000	1.000
289	HSA00251_GLUTAMATE_METABOLISM	Genes involved in glutamate metabolism	ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS	31	ABAT(9), ADC(5), ALDH4A1(6), ALDH5A1(10), CAD(15), CPS1(21), EPRS(9), GAD1(13), GAD2(7), GCLC(5), GCLM(2), GFPT1(4), GFPT2(5), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(2), GMPS(4), GOT1(6), GOT2(5), GPT(3), GPT2(1), GSR(2), GSS(7), NADSYN1(4), NAGK(1), QARS(6)	13224692	163	84	157	87	91	21	11	25	15	0	0.438	1.000	1.000
290	HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS	Genes involved in ubiquitin mediated proteolysis	ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2	39	ANAPC1(16), ANAPC10(1), ANAPC2(4), ANAPC4(4), ANAPC5(6), ANAPC7(6), BTRC(4), CDC16(1), CDC20(1), CDC23(3), CDC27(13), CUL1(5), CUL2(4), CUL3(4), FBXW11(5), FBXW7(11), FZR1(6), ITCH(7), SKP2(2), SMURF1(1), SMURF2(9), TCEB1(1), TCEB2(1), UBA1(3), UBE2D1(1), UBE2D3(3), UBE2E1(1), UBE2E2(4), UBE2E3(1), VHL(4), WWP1(3), WWP2(7)	13340391	142	84	133	60	84	4	11	23	19	1	0.562	1.000	1.000
291	PITX2PATHWAY	The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation.	APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1	14	APC(19), AXIN1(10), CREBBP(20), CTNNB1(11), EP300(14), FZD1(4), GSK3B(2), HDAC1(1), LDB1(2), LEF1(3), PITX2(4), TRRAP(40), WNT1(2)	11122495	132	84	128	74	71	10	10	22	19	0	0.915	1.000	1.000
292	HISTIDINE_METABOLISM		ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2	24	ABP1(18), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH3B1(2), ALDH3B2(7), ALDH9A1(2), AOC2(7), AOC3(8), ASPA(3), CNDP1(8), DDC(12), HAL(12), HARS(6), HDC(19), HNMT(1), MAOA(3), MAOB(13), PRPS1(2), PRPS2(3)	8128303	162	83	158	106	108	15	10	14	15	0	0.657	1.000	1.000
293	IL1RPATHWAY	The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons.	CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6	31	CHUK(2), IFNA1(1), IFNB1(6), IKBKB(3), IL1A(4), IL1B(6), IL1R1(11), IL1RAP(4), IL1RN(8), IL6(2), IRAK1(4), IRAK2(14), IRAK3(7), JUN(1), MAP2K3(7), MAP2K6(3), MAP3K1(2), MAP3K14(3), MAP3K7(1), MAPK14(5), MAPK8(1), MYD88(3), NFKB1(7), NFKBIA(2), RELA(4), TGFB1(1), TGFB2(1), TGFB3(3), TNF(1), TOLLIP(1), TRAF6(4)	9854248	122	83	119	66	75	12	4	18	13	0	0.543	1.000	1.000
294	PROPANOATE_METABOLISM		ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2	31	ABAT(9), ACACA(21), ACADL(4), ACADM(5), ACADSB(6), ACAT2(1), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH6A1(3), ALDH9A1(2), ECHS1(2), EHHADH(6), HADHA(8), LDHA(5), LDHB(2), LDHC(5), MCEE(2), MLYCD(2), MUT(5), PCCA(3), PCCB(2), SDS(2), SUCLG1(2), SUCLG2(2)	11127967	135	82	131	68	84	12	10	22	7	0	0.528	1.000	1.000
295	ALANINE_AND_ASPARTATE_METABOLISM		AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC	21	AARS(5), ABAT(9), ADSL(6), ADSS(2), AGXT(10), AGXT2(20), ASL(6), ASNS(8), ASPA(3), CAD(15), CRAT(5), DARS(4), DDO(7), GAD1(13), GAD2(7), GOT1(6), GOT2(5), GPT(3), GPT2(1), NARS(2), PC(12)	8754370	149	81	142	75	104	15	9	14	7	0	0.0799	1.000	1.000
296	DCPATHWAY	Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation.	ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5	20	ANPEP(17), CD33(17), CD5(6), CSF2(2), IFNA1(1), IFNB1(6), IFNG(2), IL10(3), IL12A(3), IL12B(3), IL13(2), IL3(3), IL4(1), IL5(4), ITGAX(18), TLR2(15), TLR4(31), TLR7(15), TLR9(14)	5960114	163	81	159	90	113	13	8	12	17	0	0.0175	1.000	1.000
297	DEATHPATHWAY	Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade.	APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2	32	APAF1(6), BCL2(2), BIRC2(5), BIRC3(7), CASP10(4), CASP3(2), CASP7(4), CASP8(8), CASP9(3), CFLAR(4), CHUK(2), CYCS(1), DFFA(2), DFFB(3), GAS2(12), LMNA(8), MAP3K14(3), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), SPTAN1(7), TNFRSF10A(5), TNFRSF10B(2), TNFRSF25(5), TNFSF10(7), TNFSF12(1), TRAF2(2)	11180538	119	81	119	72	67	14	10	20	8	0	0.890	1.000	1.000
298	FIBRINOLYSISPATHWAY	Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot.	CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1	12	CPB2(1), F13A1(26), F2(9), F2R(6), FGA(38), FGB(10), FGG(7), PLAT(3), PLAU(3), PLG(30), SERPINB2(16), SERPINE1(5)	4467595	154	81	146	60	115	11	8	12	8	0	0.0486	1.000	1.000
299	G2PATHWAY	Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2.	ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ	21	ATM(12), ATR(20), BRCA1(9), CDC25A(8), CDC25B(4), CDC25C(4), CDC34(4), CDKN1A(4), CHEK1(2), CHEK2(3), EP300(14), MDM2(3), MYT1(21), PRKDC(19), RPS6KA1(6), WEE1(2), YWHAQ(3)	13795922	138	81	135	60	81	13	8	21	15	0	0.515	1.000	1.000
300	HSA03022_BASAL_TRANSCRIPTION_FACTORS	Genes involved in basal transcription factors	GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2	32	GTF2A1(2), GTF2A1L(5), GTF2A2(1), GTF2B(3), GTF2E1(2), GTF2E2(5), GTF2F1(5), GTF2F2(2), GTF2H1(3), GTF2H3(1), GTF2H4(1), GTF2I(2), GTF2IRD1(8), TAF1(10), TAF13(2), TAF1L(53), TAF2(5), TAF4(8), TAF4B(2), TAF5L(3), TAF6(3), TAF6L(4), TAF7(2), TAF7L(11), TAF9(2), TAF9B(1), TBPL1(1), TBPL2(4)	12129318	151	81	147	64	102	12	6	22	9	0	0.299	1.000	1.000
301	OXIDATIVE_PHOSPHORYLATION		ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH	60	ATP12A(24), ATP4B(1), ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(19), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), ATP7A(9), ATP7B(17), COX10(5), COX5B(1), COX6A1(1), COX6B1(1), COX6C(1), COX7B(1), COX8A(1), NDUFA10(2), NDUFA4(1), NDUFB2(3), NDUFB5(3), NDUFB6(2), NDUFS2(2), NDUFV1(2), PPA2(3), SDHA(1), SDHB(1), SHMT1(1), UQCRC1(3), UQCRFS1(2)	12844351	156	81	155	94	94	8	18	21	15	0	0.803	1.000	1.000
302	ST_GRANULE_CELL_SURVIVAL_PATHWAY	The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides.	ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP	25	APC(19), CAMP(1), CASP3(2), CERK(1), CREB3(1), CREB5(9), DAG1(5), EPHB2(29), FOS(2), GNAQ(4), ITPKB(7), JUN(1), MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK8(1), MAPK8IP1(4), MAPK8IP2(7), MAPK8IP3(8), MAPK9(5)	9504529	126	81	124	68	76	8	5	17	20	0	0.706	1.000	1.000
303	AMIPATHWAY	Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(26), CD3D(5), CD3E(2), CD3G(1), CD4(6), CREBBP(20), CSK(1), GNAS(19), HLA-DRA(11), HLA-DRB1(3), LCK(12), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PTPRC(30), ZAP70(8)	7569321	166	80	161	97	112	14	8	17	15	0	0.677	1.000	1.000
304	BADPATHWAY	When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2.	ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH	22	ADCY1(26), AKT1(3), BAX(3), BCL2(2), CSF2RB(17), IGF1(11), IGF1R(10), IL3(3), IL3RA(7), KIT(9), KITLG(8), PIK3CA(8), PIK3R1(3), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5)	7317986	132	80	128	80	85	13	7	12	14	1	0.597	1.000	1.000
305	BUTANOATE_METABOLISM		AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS	27	AACS(7), ABAT(9), ACADS(4), ACAT2(1), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH5A1(10), ALDH9A1(2), ECHS1(2), EHHADH(6), GAD1(13), GAD2(7), HADHA(8), HMGCL(4), L2HGDH(3), OXCT1(4), PDHA1(3), PDHA2(17), PDHB(1), SDHB(1), SDS(2)	8679698	140	80	135	66	89	16	4	18	13	0	0.121	1.000	1.000
306	CSKPATHWAY	Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45.	ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70	21	ADCY1(26), CD3D(5), CD3E(2), CD3G(1), CD4(6), CREBBP(20), CSK(1), GNAS(19), HLA-DRA(11), HLA-DRB1(3), LCK(12), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PTPRC(30), ZAP70(8)	7569321	166	80	161	97	112	14	8	17	15	0	0.677	1.000	1.000
307	IL2RBPATHWAY	The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding.	AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3	34	AKT1(3), BCL2(2), CBL(8), CFLAR(4), CRKL(2), E2F1(5), FOS(2), GRB2(2), HRAS(3), IL2RA(4), IL2RB(7), IL2RG(3), IRS1(5), JAK1(6), JAK3(6), MAPK1(4), MAPK3(1), MYC(5), NMI(1), PIK3CA(8), PIK3R1(3), PPIA(1), PTPN6(3), RAF1(8), RPS6KB1(2), SHC1(1), SOCS3(2), SOS1(8), STAT5A(2), STAT5B(4), SYK(14)	12028627	129	80	127	72	74	12	11	17	14	1	0.787	1.000	1.000
308	IRINOTECAN_PATHWAY_PHARMGKB		ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6	17	ABCC1(12), ABCC2(9), ABCG2(6), BCHE(6), CES1(16), CES2(4), CYP3A4(19), CYP3A5(10), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(8), UGT1A9(10)	7667525	163	80	153	76	109	14	12	11	17	0	0.0137	1.000	1.000
309	PAR1PATHWAY	Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets.	ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1	19	ADCY1(26), ARHGEF1(1), F2(9), F2R(6), F2RL3(3), GNA12(3), GNA13(1), GNAI1(1), GNAQ(4), MAP3K7(1), PIK3CA(8), PIK3R1(3), PLCB1(48), PPP1R12B(8), PRKCA(10), PTK2B(10), ROCK1(5)	8640233	147	80	140	77	103	10	5	17	11	1	0.401	1.000	1.000
310	PYK2PATHWAY	Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38.	BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1	27	BCAR1(4), CALM1(1), CALM2(1), CRKL(2), GNAQ(4), GRB2(2), HRAS(3), JUN(1), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K4(4), MAP3K1(2), MAPK1(4), MAPK14(5), MAPK3(1), MAPK8(1), PAK1(4), PLCG1(9), PRKCA(10), PTK2B(10), RAF1(8), SHC1(1), SOS1(8), SRC(1), SYT1(19)	9368287	125	80	114	72	77	11	5	20	12	0	0.842	1.000	1.000
311	EXTRINSICPATHWAY	The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade.	F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI	13	F10(8), F2(9), F2R(6), F5(30), F7(7), FGA(38), FGB(10), FGG(7), PROC(8), PROS1(13), SERPINC1(7), TFPI(8)	5493980	151	79	140	59	102	20	9	12	8	0	0.0545	1.000	1.000
312	SIG_CD40PATHWAYMAP	Genes related to CD40 signaling	DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6	32	MAP2K4(4), MAP2K7(4), MAPK1(4), MAPK10(8), MAPK11(1), MAPK12(1), MAPK13(4), MAPK14(5), MAPK3(1), MAPK8(1), MAPK8IP1(4), MAPK8IP2(7), MAPK8IP3(8), MAPK9(5), MAPKAPK5(1), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), PIK3CA(8), PIK3CD(7), PIK3R1(3), SYT1(19), TRAF2(2), TRAF3(5), TRAF5(7), TRAF6(4)	11171128	134	79	128	81	84	9	6	24	10	1	0.692	1.000	1.000
313	CDMACPATHWAY	Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway.	CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF	15	CUZD1(16), FOS(2), HRAS(3), JUN(1), MAP2K1(10), MAPK1(4), MAPK3(1), MYC(5), NFKB1(7), NFKBIA(2), PLCB1(48), PRKCA(10), RAF1(8), RELA(4), TNF(1)	5212313	122	78	111	49	84	8	6	14	10	0	0.0225	1.000	1.000
314	EGFPATHWAY	The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways.	CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), EGF(18), EGFR(22), ELK1(2), FOS(2), GRB2(2), HRAS(3), JAK1(6), JUN(1), MAP2K1(10), MAP2K4(4), MAP3K1(2), MAPK3(1), MAPK8(1), PIK3CA(8), PIK3R1(3), PLCG1(9), PRKCA(10), RAF1(8), RASA1(4), SHC1(1), SOS1(8), SRF(2), STAT1(4), STAT3(10), STAT5A(2)	12513816	144	78	137	78	84	14	7	25	13	1	0.893	1.000	1.000
315	P38MAPKPATHWAY	The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines.	ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2	38	ATF2(5), CDC42(2), DAXX(9), DDIT3(2), ELK1(2), GRB2(2), HMGN1(2), HRAS(3), HSPB1(2), HSPB2(1), MAP2K4(4), MAP2K6(3), MAP3K1(2), MAP3K5(16), MAP3K7(1), MAP3K9(22), MAPK14(5), MAPKAPK2(7), MAPKAPK5(1), MEF2A(5), MEF2B(2), MEF2C(2), MEF2D(4), MKNK1(5), MYC(5), PLA2G4A(11), RIPK1(1), RPS6KA5(4), SHC1(1), STAT1(4), TGFB1(1), TGFB2(1), TGFB3(3), TRAF2(2)	12002968	142	78	137	58	88	12	3	20	19	0	0.263	1.000	1.000
316	FASPATHWAY	Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell.	ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6	27	ARHGDIB(3), CASP10(4), CASP3(2), CASP7(4), CASP8(8), CFLAR(4), DAXX(9), DFFA(2), DFFB(3), FAF1(7), JUN(1), LMNA(8), LMNB1(2), LMNB2(4), MAP2K4(4), MAP3K1(2), MAP3K7(1), MAPK8(1), PAK1(4), PAK2(8), PRKDC(19), PTPN13(12), RB1(8), RIPK2(2), SPTAN1(7)	13724799	129	77	129	61	58	12	10	32	15	2	0.766	1.000	1.000
317	GLUTAMATE_METABOLISM		ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS	24	ABAT(9), ALDH4A1(6), ALDH5A1(10), CAD(15), CPS1(21), EPRS(9), GAD1(13), GAD2(7), GCLC(5), GCLM(2), GFPT1(4), GLS(2), GLS2(3), GLUD1(2), GLUL(2), GMPS(4), GOT1(6), GOT2(5), GPT(3), GPT2(1), GSS(7), NADSYN1(4), QARS(6)	11120950	146	77	140	70	84	16	10	23	13	0	0.256	1.000	1.000
318	HSA00710_CARBON_FIXATION	Genes involved in carbon fixation	ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1	23	ALDOA(2), ALDOB(12), ALDOC(3), FBP1(2), FBP2(2), GOT1(6), GOT2(5), GPT(3), GPT2(1), MDH1(1), MDH2(4), ME1(19), ME3(9), PGK1(4), PGK2(27), PKLR(11), PKM2(5), TKT(6), TKTL1(1), TKTL2(24)	6780089	147	77	136	78	107	14	5	12	9	0	0.0529	1.000	1.000
319	HSA00960_ALKALOID_BIOSYNTHESIS_II	Genes involved in alkaloid biosynthesis II	AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1	18	AADAC(14), ABP1(18), AOC2(7), AOC3(8), CES1(16), CES7(14), DDHD1(6), ESCO1(1), ESCO2(2), LIPA(4), MYST3(15), MYST4(14), NAT6(2), PLA1A(9), PNPLA3(2), PPME1(1), PRDX6(4), SH3GLB1(2)	8492972	139	77	135	80	101	8	8	11	11	0	0.816	1.000	1.000
320	NKTPATHWAY	T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response.	CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5	28	CCR1(9), CCR2(16), CCR3(10), CCR4(7), CCR5(7), CCR7(3), CD28(1), CD4(6), CSF2(2), CXCR3(4), CXCR4(3), IFNG(2), IFNGR1(4), IFNGR2(4), IL12A(3), IL12B(3), IL12RB1(15), IL12RB2(3), IL18R1(17), IL2(4), IL4(1), IL4R(13), IL5(4), TGFB1(1), TGFB2(1), TGFB3(3)	6677468	146	77	139	78	104	12	1	15	14	0	0.0604	1.000	1.000
321	PDGFPATHWAY	Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A	26	CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(3), JAK1(6), JUN(1), MAP2K1(10), MAP2K4(4), MAP3K1(2), MAPK3(1), MAPK8(1), PDGFA(1), PDGFRA(27), PIK3CA(8), PIK3R1(3), PLCG1(9), PRKCA(10), RAF1(8), RASA1(4), SHC1(1), SOS1(8), SRF(2), STAT1(4), STAT3(10), STAT5A(2)	11651546	132	77	125	60	73	14	6	24	14	1	0.497	1.000	1.000
322	DNA_REPLICATION_REACTOME		ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC	42	CDC6(1), CDC7(2), CDT1(1), DIAPH2(7), MCM10(6), MCM2(10), MCM3(10), MCM4(5), MCM5(4), MCM6(4), ORC1L(5), ORC2L(1), ORC3L(1), ORC4L(3), ORC5L(1), ORC6L(2), PCNA(2), POLA2(8), POLD1(6), POLD2(2), POLD3(4), POLE(15), POLE2(3), PRIM1(3), RFC1(5), RFC2(2), RFC3(1), RPA1(3), RPA2(2), RPA3(1), RPA4(2), UBB(1), UBC(6)	16939265	129	76	128	77	77	9	5	22	16	0	0.879	1.000	1.000
323	HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2	40	AKR1B1(2), AKR1B10(8), ALDOA(2), ALDOB(12), ALDOC(3), FBP1(2), FBP2(2), FPGT(2), FUK(3), GMDS(5), GMPPA(1), GMPPB(3), HK1(3), HK2(12), HK3(13), HSD3B7(3), KHK(1), LHPP(1), MPI(1), MTMR1(4), MTMR2(2), MTMR6(2), PFKFB1(4), PFKFB2(5), PFKFB3(2), PFKFB4(5), PFKL(4), PFKM(1), PGM2(6), PMM1(2), PMM2(1), RDH11(2), RDH12(2), RDH13(3), SORD(2), TSTA3(2)	12342776	128	76	124	85	86	15	10	11	6	0	0.519	1.000	1.000
324	HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY	Genes involved in dentatorubropallidoluysian atrophy (DRPLA)	ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2	15	ATN1(5), BAIAP2(5), CASP1(4), CASP3(2), CASP7(4), CASP8(8), GAPDH(1), INSR(20), ITCH(7), MAGI1(26), MAGI2(22), RERE(21), WWP1(3), WWP2(7)	8064230	135	76	133	63	91	9	3	20	11	1	0.489	1.000	1.000
325	LYSINE_DEGRADATION		AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE	31	AADAT(5), AASDH(5), AASDHPPT(3), AASS(3), ACAT2(1), ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2), BBOX1(4), DOT1L(8), ECHS1(2), EHHADH(6), EHMT1(7), EHMT2(9), GCDH(5), HADHA(8), PLOD1(5), PLOD2(6), PLOD3(4), SDS(2), SHMT1(1), SHMT2(2), TMLHE(1)	12307643	125	76	121	73	78	14	4	20	9	0	0.623	1.000	1.000
326	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS		AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4	17	AKR1B1(2), GUSB(3), UCHL1(4), UCHL3(2), UGDH(1), UGT1A1(4), UGT1A10(14), UGT1A3(10), UGT1A4(8), UGT1A5(11), UGT1A6(5), UGT1A7(11), UGT1A8(8), UGT1A9(10), UGT2B4(31)	5239102	124	76	112	65	87	13	10	5	8	1	0.191	1.000	1.000
327	RNA_TRANSCRIPTION_REACTOME		CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L	36	CCNH(2), ERCC3(4), GTF2A2(1), GTF2B(3), GTF2E1(2), GTF2E2(5), GTF2F2(2), GTF2H1(3), GTF2H4(1), MNAT1(2), POLR1A(11), POLR1B(8), POLR2A(11), POLR2B(11), POLR2C(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR3B(17), POLR3D(1), POLR3E(4), POLR3H(1), POLR3K(1), TAF13(2), TAF6(3), TAF7(2), TAF9(2), TBP(4)	11766125	111	76	108	47	65	11	8	19	8	0	0.238	1.000	1.000
328	EIF4PATHWAY	The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging.	AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1	21	AKT1(3), EIF4A1(3), EIF4A2(3), EIF4EBP1(1), EIF4G1(13), EIF4G2(5), EIF4G3(17), GHR(25), IRS1(5), MAPK1(4), MAPK14(5), MAPK3(1), MKNK1(5), PABPC1(5), PDK2(4), PDPK1(4), PIK3CA(8), PIK3R1(3), PRKCA(10), RPS6KB1(2)	9207918	126	75	120	51	75	15	7	12	16	1	0.188	1.000	1.000
329	MYOSINPATHWAY	Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes.	ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1	13	ARHGAP5(11), ARHGEF1(1), GNA12(3), GNA13(1), GNAQ(4), MYL2(5), MYLK(39), PLCB1(48), PPP1R12B(8), PRKCA(10), ROCK1(5)	6957125	135	75	124	61	105	4	5	13	8	0	0.160	1.000	1.000
330	NKCELLSPATHWAY	Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis.	B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1	19	B2M(5), HLA-A(6), IL18(2), ITGB1(4), KLRC1(4), KLRC2(1), KLRC3(11), KLRC4(5), KLRD1(5), LAT(1), MAP2K1(10), MAPK3(1), PAK1(4), PIK3CA(8), PIK3R1(3), PTK2B(10), PTPN6(3), SYK(14), VAV1(15)	6061467	112	75	102	67	78	4	4	12	13	1	0.846	1.000	1.000
331	ETSPATHWAY	The Ets transcription factors are activated by Ras and promote macrophage differentiation.	CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B	18	CSF1(10), CSF1R(12), DDX20(8), E2F1(5), E2F4(1), ETS1(4), ETS2(8), ETV3(4), FOS(2), HDAC2(1), HDAC5(6), HRAS(3), JUN(1), NCOR2(24), RBL1(10), RBL2(4), SIN3A(9), SIN3B(7)	8690075	119	74	119	61	78	7	2	21	11	0	0.361	1.000	1.000
332	IL7PATHWAY	IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination.	BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B	16	BCL2(2), CREBBP(20), EP300(14), FYN(6), IL2RG(3), IL7(5), IL7R(27), JAK1(6), JAK3(6), LCK(12), NMI(1), PIK3CA(8), PIK3R1(3), PTK2B(10), STAT5A(2), STAT5B(4)	9325820	129	74	126	67	80	13	5	19	11	1	0.652	1.000	1.000
333	LYMPHOCYTEPATHWAY	B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells.	CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL	9	CD44(5), ICAM1(2), ITGA4(36), ITGAL(24), ITGB1(4), ITGB2(13), SELE(34), SELL(8)	4009140	126	74	122	39	94	4	4	9	15	0	0.00256	1.000	1.000
334	CARDIACEGFPATHWAY	Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway.	ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA	16	ADAM12(10), AGT(5), AGTR2(9), EDN1(8), EDNRA(8), EDNRB(4), EGF(18), EGFR(22), FOS(2), HRAS(3), JUN(1), MYC(5), NFKB1(7), PLCG1(9), PRKCA(10), RELA(4)	6869611	125	73	122	66	88	10	5	15	7	0	0.356	1.000	1.000
335	CBLPATHWAY	Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl.	CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC	12	CBL(8), CSF1R(12), EGF(18), EGFR(22), GRB2(2), MET(19), PDGFRA(27), PRKCA(10), SH3GLB1(2), SH3GLB2(1), SH3KBP1(6), SRC(1)	6521461	128	73	127	79	86	10	6	13	13	0	0.874	1.000	1.000
336	G1PATHWAY	CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition.	ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53	23	ABL1(12), ATM(12), ATR(20), CCNA1(13), CCND1(1), CCNE1(4), CDC25A(8), CDK4(5), CDK6(2), CDKN1A(4), CDKN1B(1), E2F1(5), GSK3B(2), HDAC1(1), RB1(8), SKP2(2), TFDP1(2), TGFB1(1), TGFB2(1), TGFB3(3)	9612115	107	73	105	42	60	7	8	16	14	2	0.168	1.000	1.000
337	GLYCOSPHINGOLIPID_METABOLISM		ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG	23	ARSB(1), ARSD(3), ARSE(5), GAL3ST1(8), GALC(3), GBA(3), GLA(1), GLB1(8), LCT(40), NEU1(7), NEU2(14), NEU3(3), NEU4(9), PPAP2B(6), PPAP2C(8), SMPD1(3), SMPD2(1), SPTLC1(1), SPTLC2(6), UGCG(1)	8008281	131	73	127	80	93	13	2	15	8	0	0.690	1.000	1.000
338	HSA00020_CITRATE_CYCLE	Genes involved in citrate cycle (TCA cycle)	ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2	26	ACLY(9), ACO1(5), ACO2(4), CLYBL(5), CS(2), DLD(2), FH(3), IDH2(2), IDH3A(3), IDH3B(1), IDH3G(2), MDH1(1), MDH2(4), OGDH(11), OGDHL(36), PC(12), PCK1(23), PCK2(4), SDHA(1), SDHB(1), SDHC(2), SDHD(1), SUCLG1(2), SUCLG2(2)	9755178	138	73	132	71	96	4	7	17	14	0	0.204	1.000	1.000
339	NTHIPATHWAY	Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response.	CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF	22	CHUK(2), CREBBP(20), EP300(14), IKBKB(3), IL1B(6), IL8(1), MAP2K3(7), MAP2K6(3), MAP3K14(3), MAP3K7(1), MAPK11(1), MAPK14(5), MYD88(3), NFKB1(7), NFKBIA(2), NR3C1(7), RELA(4), TGFBR2(8), TLR2(15), TNF(1)	9940107	113	73	112	64	67	15	5	19	7	0	0.872	1.000	1.000
340	VIPPATHWAY	Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP.	CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2	27	CALM1(1), CALM2(1), CHUK(2), EGR2(4), EGR3(2), GNAQ(4), MAP3K1(2), MYC(5), NFATC1(15), NFATC2(9), NFKB1(7), NFKBIA(2), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RELA(4), SYT1(19), VIP(4), VIPR2(5)	9322411	128	73	124	81	87	10	7	15	9	0	0.903	1.000	1.000
341	BIOGENIC_AMINE_SYNTHESIS		AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1	15	AANAT(1), ACHE(6), CHAT(14), COMT(3), DBH(13), DDC(12), GAD1(13), GAD2(7), HDC(19), MAOA(3), PAH(8), PNMT(4), SLC18A3(2), TH(9), TPH1(5)	4722413	119	72	114	73	95	9	4	3	8	0	0.233	1.000	1.000
342	HSA03030_DNA_POLYMERASE	Genes involved in DNA polymerase	POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5	23	POLA1(2), POLA2(8), POLD1(6), POLD2(2), POLD3(4), POLE(15), POLE2(3), POLG(8), POLG2(5), POLH(3), POLI(1), POLK(6), POLL(7), POLM(2), POLQ(23), PRIM1(3), REV1(3), REV3L(11)	13263824	112	72	111	53	60	6	7	24	15	0	0.729	1.000	1.000
343	MRPPATHWAY	Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells.	ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1	6	ABCB1(35), ABCB11(45), ABCB4(17), ABCC1(12), ABCC3(25), GSTP1(2)	4755147	136	72	128	67	89	15	5	11	16	0	0.00784	1.000	1.000
344	O_GLYCAN_BIOSYNTHESIS		GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17	14	GALNT1(4), GALNT10(6), GALNT2(6), GALNT3(3), GALNT4(4), GALNT6(15), GALNT7(5), GALNT8(23), GALNT9(5), GCNT1(6), ST3GAL1(6), ST3GAL2(1), ST3GAL4(1), WBSCR17(37)	4849146	122	72	114	57	92	8	4	9	9	0	0.121	1.000	1.000
345	CREBPATHWAY	CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling.	ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1	25	ADCY1(26), AKT1(3), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), GNAS(19), GRB2(2), HRAS(3), MAPK1(4), MAPK14(5), MAPK3(1), PIK3CA(8), PIK3R1(3), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10), RPS6KA1(6), RPS6KA5(4), SOS1(8)	9522687	142	71	137	96	96	11	6	13	15	1	0.969	1.000	1.000
346	REELINPATHWAY	Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1.	CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR	7	CDK5(4), DAB1(40), FYN(6), LRP8(3), RELN(70), VLDLR(5)	4675358	128	71	123	64	92	7	3	12	14	0	0.659	1.000	1.000
347	SIG_IL4RECEPTOR_IN_B_LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes	AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6	27	AKT1(3), AKT2(8), AKT3(4), BCL2(2), GRB2(2), GSK3B(2), IL4R(13), IRS1(5), IRS2(2), JAK1(6), JAK3(6), MAP4K1(9), MAPK1(4), MAPK3(1), PDK1(2), PIK3CA(8), PIK3CD(7), PIK3R1(3), PPP1R13B(6), RAF1(8), SHC1(1), SOS1(8), SOS2(11), STAT6(7)	12211749	128	71	127	55	72	16	5	21	13	1	0.196	1.000	1.000
348	TELPATHWAY	Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes.	AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5	14	AKT1(3), BCL2(2), EGFR(22), IGF1R(10), MYC(5), POLR2A(11), PPP2CA(1), PRKCA(10), RB1(8), TEP1(30), TERF1(2), TERT(6), TNKS(7), XRCC5(2)	9128282	119	71	117	74	75	10	8	14	10	2	0.798	1.000	1.000
349	WNTPATHWAY	The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin.	APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1	22	APC(19), AXIN1(10), BTRC(4), CCND1(1), CREBBP(20), CSNK1A1(2), CSNK1D(1), CSNK2A1(1), CTNNB1(11), FZD1(4), GSK3B(2), HDAC1(1), MAP3K7(1), MYC(5), NLK(5), PPARD(3), PPP2CA(1), TLE1(4), WIF1(7), WNT1(2)	9761165	104	71	103	55	54	7	8	16	19	0	0.865	1.000	1.000
350	ATRBRCAPATHWAY	BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility.	ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1	20	ATM(12), ATR(20), BRCA1(9), BRCA2(19), CHEK1(2), CHEK2(3), FANCA(7), FANCC(3), FANCD2(12), FANCE(2), FANCF(1), FANCG(4), HUS1(1), MRE11A(5), RAD1(2), RAD17(5), RAD50(5), RAD9A(5)	14495708	117	70	115	57	76	4	6	17	14	0	0.826	1.000	1.000
351	CK1PATHWAY	Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway.	CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	17	CDK5(4), CSNK1D(1), DRD1(8), DRD2(15), GRM1(16), PLCB1(48), PPP1CA(1), PPP1R1B(2), PPP2CA(1), PPP3CA(5), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5)	5328567	123	70	117	81	95	2	6	11	9	0	0.696	1.000	1.000
352	HSA00530_AMINOSUGARS_METABOLISM	Genes involved in aminosugars metabolism	AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1	29	AMDHD2(3), CHIA(9), CHIT1(11), CMAS(1), CTBS(8), CYB5R1(1), GFPT1(4), GFPT2(5), GNE(3), HEXA(5), HEXB(4), HK1(3), HK2(12), HK3(13), LHPP(1), MTMR1(4), MTMR2(2), MTMR6(2), NAGK(1), NANS(1), PGM3(1), RENBP(3), UAP1(2)	9585564	99	70	97	57	61	9	5	13	11	0	0.685	1.000	1.000
353	STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS		EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR	10	EPX(7), GBA3(14), LPO(18), MPO(11), PRDX1(2), PRDX2(2), PRDX6(4), TPO(40), TYR(8)	3233745	106	70	101	54	82	9	1	5	9	0	0.102	1.000	1.000
354	HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION	Genes involved in glycosaminoglycan degradation	ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1	17	ARSB(1), GALNS(4), GLB1(8), GNS(2), GUSB(3), HEXA(5), HEXB(4), HGSNAT(5), HPSE(10), HPSE2(4), HYAL1(2), HYAL2(1), IDS(9), IDUA(4), LCT(40), NAGLU(4), SPAM1(20)	6796684	126	69	123	71	93	7	2	12	12	0	0.499	1.000	1.000
355	HSA00565_ETHER_LIPID_METABOLISM	Genes involved in ether lipid metabolism	AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C	30	AGPAT1(2), AGPAT2(3), AGPAT3(6), AGPAT4(7), AGPAT6(2), AGPS(3), CHPT1(1), ENPP2(1), ENPP6(11), PAFAH1B1(4), PAFAH1B2(2), PAFAH1B3(1), PAFAH2(2), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9), PLD1(11), PLD2(5), PPAP2B(6), PPAP2C(8)	7807121	132	69	128	72	85	11	4	17	15	0	0.489	1.000	1.000
356	ST_ERK1_ERK2_MAPK_PATHWAY	The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2.	ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3	28	ATF1(4), CREB3(1), CREB5(9), DUSP4(1), DUSP6(1), DUSP9(3), EEF2K(5), GRB2(2), MAP2K1(10), MAP2K2(3), MAPK1(4), MAPK3(1), MKNK1(5), MKNK2(2), MOS(5), NFKB1(7), RAP1A(2), RPS6KA1(6), RPS6KA2(7), RPS6KA3(2), SHC1(1), SOS1(8), SOS2(11), TRAF3(5)	9331027	105	69	98	62	71	8	4	14	8	0	0.858	1.000	1.000
357	ACE_INHIBITOR_PATHWAY_PHARMGKB		ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN	8	ACE(34), AGT(5), AGTR1(10), AGTR2(9), BDKRB2(9), KNG1(11), NOS3(16), REN(9)	3307680	103	68	97	60	68	7	6	12	10	0	0.176	1.000	1.000
358	C21_STEROID_HORMONE_METABOLISM		AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(9), AKR1D1(17), CYP11A1(13), CYP11B1(13), CYP11B2(13), CYP17A1(7), CYP21A2(15), HSD11B1(11), HSD11B2(2), HSD3B1(10), HSD3B2(10)	3273508	120	68	109	60	83	10	5	12	10	0	0.00916	1.000	1.000
359	HSA00140_C21_STEROID_HORMONE_METABOLISM	Genes involved in C21-steroid hormone metabolism	AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2	11	AKR1C4(9), AKR1D1(17), CYP11A1(13), CYP11B1(13), CYP11B2(13), CYP17A1(7), CYP21A2(15), HSD11B1(11), HSD11B2(2), HSD3B1(10), HSD3B2(10)	3273508	120	68	109	60	83	10	5	12	10	0	0.00916	1.000	1.000
360	HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS	Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis	GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ	23	GPAA1(1), GPLD1(20), PGAP1(5), PIGA(2), PIGB(4), PIGC(3), PIGF(2), PIGG(10), PIGH(1), PIGK(6), PIGL(2), PIGM(2), PIGN(3), PIGO(12), PIGQ(8), PIGS(1), PIGT(1), PIGU(6), PIGV(7), PIGW(2), PIGX(2), PIGZ(3)	8006895	103	68	101	43	59	8	8	20	8	0	0.0744	1.000	1.000
361	MPRPATHWAY	Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase.	ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC	22	ACTA1(4), ADCY1(26), CAP1(1), CDC25C(4), GNAI1(1), GNAS(19), HRAS(3), MAPK1(4), MAPK3(1), MYT1(21), PIN1(1), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RPS6KA1(6), SRC(1)	6849519	114	68	110	87	81	8	4	8	13	0	0.951	1.000	1.000
362	TPOPATHWAY	Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation.	CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO	22	CSNK2A1(1), FOS(2), GRB2(2), HRAS(3), JAK2(9), JUN(1), MAP2K1(10), MAPK3(1), MPL(7), PIK3CA(8), PIK3R1(3), PLCG1(9), PRKCA(10), RAF1(8), RASA1(4), SHC1(1), SOS1(8), STAT1(4), STAT3(10), STAT5A(2), STAT5B(4), THPO(7)	9990156	114	67	107	52	63	11	7	22	10	1	0.591	1.000	1.000
363	CFTRPATHWAY	The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor.	ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2	11	ADCY1(26), ADRB2(2), CFTR(44), GNAS(19), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), SLC9A3R1(3)	4325212	116	66	109	80	80	8	6	10	12	0	0.889	1.000	1.000
364	EGFR_SMRTEPATHWAY	EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers.	EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145	10	EGF(18), EGFR(22), MAP2K1(10), MAP3K1(2), MAPK14(5), NCOR2(24), RARA(3), RXRA(4), THRA(2), THRB(14)	5735374	104	66	99	55	75	7	3	13	6	0	0.513	1.000	1.000
365	EPHA4PATHWAY	Eph Kinases and ephrins support platelet aggregation	ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP	10	ACTA1(4), EPHA4(17), EPHB1(25), FYN(6), ITGA1(18), ITGB1(4), L1CAM(8), LYN(6), RAP1B(1), SELP(30)	5279238	119	66	109	65	87	4	2	16	10	0	0.539	1.000	1.000
366	HSA00450_SELENOAMINO_ACID_METABOLISM	Genes involved in selenoamino acid metabolism	AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22	26	AHCY(5), CARM1(6), CBS(6), CTH(1), GGT1(6), HEMK1(4), LCMT1(4), MARS(6), MARS2(4), MAT1A(5), MAT2B(2), METTL2B(7), METTL6(2), PAPSS1(3), PAPSS2(5), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), SCLY(3), SEPHS1(4), SEPHS2(2), WBSCR22(1)	8396360	100	66	99	45	61	11	5	15	8	0	0.107	1.000	1.000
367	PLCEPATHWAY	Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production.	ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B	11	ADCY1(26), ADRB2(2), GNAS(19), PLCE1(48), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5)	4878055	117	66	111	71	80	9	7	11	10	0	0.724	1.000	1.000
368	SHHPATHWAY	Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors.	DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU	14	DYRK1A(4), DYRK1B(2), GLI2(36), GLI3(15), GSK3B(2), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), SHH(4), SMO(10), SUFU(2)	5543702	97	66	94	57	64	10	7	8	8	0	0.584	1.000	1.000
369	TNFR1PATHWAY	Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis.	ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2	28	ARHGDIB(3), BAG4(3), CASP2(1), CASP3(2), CASP8(8), CRADD(1), DFFA(2), DFFB(3), JUN(1), LMNA(8), LMNB1(2), LMNB2(4), MADD(14), MAP2K4(4), MAP3K1(2), MAP3K7(1), MAPK8(1), PAK1(4), PAK2(8), PRKDC(19), RB1(8), RIPK1(1), SPTAN1(7), TNF(1), TNFRSF1A(3), TRAF2(2)	13034184	113	66	112	51	51	11	9	25	15	2	0.442	1.000	1.000
370	CALCINEURINPATHWAY	Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes.	CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1	17	CALM1(1), CALM2(1), CDKN1A(4), GNAQ(4), NFATC1(15), NFATC2(9), NFATC3(9), NFATC4(13), PLCG1(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(10), SP1(5), SP3(1), SYT1(19)	6942662	111	65	106	46	74	10	6	11	10	0	0.162	1.000	1.000
371	GABAPATHWAY	Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering.	DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1	12	DNM1(8), GABRA1(16), GABRA2(15), GABRA3(19), GABRA4(12), GABRA5(2), GABRA6(22), GPHN(7), NSF(1), SRC(1), UBQLN1(5)	3922143	108	65	96	58	81	4	5	10	7	1	0.397	1.000	1.000
372	GCRPATHWAY	Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response.	ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1	17	ADRB2(2), AKT1(3), ANXA1(4), CALM1(1), CALM2(1), GNAS(19), NFKB1(7), NOS3(16), NPPA(3), NR3C1(7), PIK3CA(8), PIK3R1(3), RELA(4), SYT1(19)	5939665	97	65	90	55	71	6	2	14	3	1	0.803	1.000	1.000
373	GLEEVECPATHWAY	The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia.	AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B	22	AKT1(3), BCL2(2), BCR(10), CRKL(2), FOS(2), GRB2(2), HRAS(3), JAK2(9), JUN(1), MAP2K1(10), MAP2K4(4), MAP3K1(2), MAPK3(1), MAPK8(1), MYC(5), PIK3CA(8), PIK3R1(3), RAF1(8), SOS1(8), STAT1(4), STAT5A(2), STAT5B(4)	9346738	94	65	88	45	50	8	6	18	11	1	0.665	1.000	1.000
374	HSA00030_PENTOSE_PHOSPHATE_PATHWAY	Genes involved in pentose phosphate pathway	ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2	26	ALDOA(2), ALDOB(12), ALDOC(3), DERA(2), FBP1(2), FBP2(2), G6PD(3), GPI(3), H6PD(5), PFKL(4), PFKM(1), PGD(7), PGLS(1), PGM1(4), PGM3(1), PRPS1(2), PRPS1L1(13), PRPS2(3), RBKS(4), TALDO1(3), TKT(6), TKTL1(1), TKTL2(24)	8105277	108	65	102	73	72	11	5	7	13	0	0.552	1.000	1.000
375	IL12PATHWAY	IL12 and Stat4 Dependent Signaling Pathway in Th1 Development	CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2	20	CCR5(7), CD3D(5), CD3E(2), CD3G(1), CXCR3(4), ETV5(7), IFNG(2), IL12A(3), IL12B(3), IL12RB1(15), IL12RB2(3), IL18(2), IL18R1(17), JAK2(9), JUN(1), MAP2K6(3), MAPK14(5), MAPK8(1), STAT4(22), TYK2(7)	6206349	119	65	116	59	81	8	4	15	11	0	0.446	1.000	1.000
376	IL2PATHWAY	IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK	22	CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(3), IL2(4), IL2RA(4), IL2RB(7), IL2RG(3), JAK1(6), JAK3(6), JUN(1), LCK(12), MAP2K1(10), MAPK3(1), MAPK8(1), RAF1(8), SHC1(1), SOS1(8), STAT5A(2), STAT5B(4), SYK(14)	7690955	102	65	96	49	63	9	5	16	9	0	0.337	1.000	1.000
377	PGC1APATHWAY	PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH	23	CALM1(1), CALM2(1), CAMK1(4), CAMK1G(9), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CAMK4(10), ESRRA(2), HDAC5(6), MEF2A(5), MEF2B(2), MEF2C(2), MEF2D(4), PPARA(6), PPP3CA(5), PPP3CB(4), PPP3CC(2), SLC2A4(8), SYT1(19)	6706586	108	65	101	64	80	6	3	11	8	0	0.529	1.000	1.000
378	PLCPATHWAY	Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx.	AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1	7	AKT1(3), PIK3CA(8), PIK3R1(3), PLCB1(48), PLCG1(9), PRKCA(10), VAV1(15)	4303263	96	65	90	49	76	3	2	8	6	1	0.386	1.000	1.000
379	HSA00480_GLUTATHIONE_METABOLISM	Genes involved in glutathione metabolism	ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12	35	ANPEP(17), G6PD(3), GCLC(5), GCLM(2), GGT1(6), GPX1(7), GPX3(3), GPX5(12), GPX6(15), GSR(2), GSS(7), GSTA1(5), GSTA2(2), GSTA3(1), GSTA5(3), GSTK1(2), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTP1(2), GSTT1(1), IDH2(2), MGST1(2), MGST2(2), MGST3(1), OPLAH(8), TXNDC12(1)	7017990	127	64	121	71	84	8	6	20	9	0	0.189	1.000	1.000
380	HSA00511_N_GLYCAN_DEGRADATION	Genes involved in N-glycan degradation	AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	15	AGA(4), FUCA1(2), GLB1(8), HEXA(5), HEXB(4), LCT(40), MAN2B1(7), MAN2B2(8), MAN2C1(3), MANBA(7), NEU1(7), NEU2(14), NEU3(3), NEU4(9)	6782316	121	64	119	59	90	11	3	12	5	0	0.145	1.000	1.000
381	HSA00940_PHENYLPROPANOID_BIOSYNTHESIS	Genes involved in phenylpropanoid biosynthesis	EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO	7	EPX(7), GBA(3), GBA3(14), LPO(18), MPO(11), PRDX6(4), TPO(40)	2807448	97	64	92	52	76	8	1	5	7	0	0.102	1.000	1.000
382	KREBS_TCA_CYCLE		ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50	30	ACO2(4), CS(2), DLAT(2), DLD(2), FH(3), IDH2(2), IDH3A(3), IDH3B(1), IDH3G(2), MDH1(1), MDH2(4), OGDH(11), PC(12), PDHA1(3), PDHA2(17), PDHB(1), PDHX(2), PDK1(2), PDK2(4), PDK3(4), PDK4(8), PDP2(5), SDHA(1), SDHB(1), SDHC(2), SDHD(1), SUCLG1(2), SUCLG2(2)	9528058	104	64	100	47	70	5	6	11	12	0	0.178	1.000	1.000
383	NFKBPATHWAY	Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes.	CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	21	CHUK(2), IKBKB(3), IL1A(4), IL1R1(11), IRAK1(4), MAP3K1(2), MAP3K14(3), MAP3K7(1), MYD88(3), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), TLR4(31), TNF(1), TNFAIP3(2), TNFRSF1A(3), TNFRSF1B(3), TRAF6(4)	8015050	91	64	88	58	62	6	5	10	8	0	0.862	1.000	1.000
384	RARRXRPATHWAY	RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed.	ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP	14	ERCC3(4), GTF2A1(2), GTF2B(3), GTF2E1(2), GTF2F1(5), HDAC3(5), NCOA1(9), NCOA2(13), NCOA3(14), NCOR2(24), POLR2A(11), RARA(3), RXRA(4), TBP(4)	8309508	103	64	101	47	78	3	5	10	7	0	0.240	1.000	1.000
385	UCALPAINPATHWAY	Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain.	ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2	15	ACTA1(4), ACTN1(5), ACTN2(21), ACTN3(7), CAPN1(4), CAPNS1(1), ITGA1(18), ITGB1(4), ITGB3(11), PTK2(8), PXN(3), SPTAN1(7), SRC(1), TLN1(12)	9277143	106	64	104	60	68	9	5	12	11	1	0.230	1.000	1.000
386	FRUCTOSE_AND_MANNOSE_METABOLISM		AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1	25	AKR1B1(2), ALDOA(2), ALDOB(12), ALDOC(3), FBP1(2), FBP2(2), FPGT(2), GCK(17), GMDS(5), GMPPA(1), GMPPB(3), HK1(3), HK2(12), HK3(13), KHK(1), MPI(1), PFKFB1(4), PFKFB3(2), PFKFB4(5), PFKM(1), PMM1(2), PMM2(1), SORD(2)	7964637	98	63	93	68	71	13	6	4	4	0	0.433	1.000	1.000
387	HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS	Genes involved in valine, leucine and isoleucine biosynthesis	BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2	12	BCAT1(11), BCAT2(1), IARS(8), IARS2(13), ILVBL(4), LARS(10), LARS2(4), PDHA1(3), PDHA2(17), PDHB(1), VARS(18), VARS2(6)	6323882	96	63	86	41	61	11	3	12	9	0	0.197	1.000	1.000
388	MTORPATHWAY	Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation.	AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2	20	AKT1(3), EIF4A1(3), EIF4A2(3), EIF4B(4), EIF4EBP1(1), EIF4G1(13), EIF4G2(5), EIF4G3(17), FKBP1A(2), MKNK1(5), PDK2(4), PDPK1(4), PIK3CA(8), PIK3R1(3), PPP2CA(1), RPS6(1), RPS6KB1(2), TSC1(5), TSC2(11)	9001463	95	63	92	40	50	11	8	12	12	2	0.316	1.000	1.000
389	CHREBPPATHWAY	Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels.	ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14	17	ADCY1(26), GNAS(19), PPP2CA(1), PRKAA1(1), PRKAA2(24), PRKAB1(2), PRKAB2(2), PRKACB(4), PRKACG(8), PRKAG1(2), PRKAG2(7), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5)	5103428	106	62	101	63	75	8	7	4	12	0	0.729	1.000	1.000
390	ERBB4PATHWAY	ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors.	ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1	6	ADAM17(1), ERBB4(47), NRG2(7), NRG3(20), PRKCA(10), PSEN1(1)	2982990	86	62	78	31	67	4	2	5	8	0	0.0376	1.000	1.000
391	FLUMAZENILPATHWAY	Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes.	GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1	9	GABRA1(16), GABRA2(15), GABRA3(19), GABRA4(12), GABRA5(2), GABRA6(22), GPX1(7), PRKCE(6)	2582029	99	62	85	49	71	5	3	12	7	1	0.249	1.000	1.000
392	HSA00232_CAFFEINE_METABOLISM	Genes involved in caffeine metabolism	CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH	7	CYP1A2(10), CYP2A13(11), CYP2A6(11), CYP2A7(8), NAT1(2), NAT2(9), XDH(50)	2690942	101	62	95	60	80	4	8	4	5	0	0.0660	1.000	1.000
393	HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM	Genes involved in nicotinate and nicotinamide metabolism	AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT	22	AOX1(21), BST1(1), CD38(4), ENPP1(11), ENPP3(14), NADK(4), NADSYN1(4), NMNAT2(3), NMNAT3(8), NNMT(9), NNT(3), NT5C1A(3), NT5C1B(22), NT5C2(3), NT5C3(2), NT5E(4), NT5M(2), NUDT12(1), QPRT(6)	7215895	125	62	121	66	81	10	6	13	15	0	0.505	1.000	1.000
394	HSA00910_NITROGEN_METABOLISM	Genes involved in nitrogen metabolism	AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL	24	AMT(1), ASNS(8), ASRGL1(3), CA1(8), CA12(3), CA13(5), CA2(9), CA3(5), CA4(3), CA5A(2), CA5B(1), CA6(4), CA7(1), CA8(4), CA9(8), CPS1(21), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUD2(4), GLUL(2), HAL(12)	7049279	112	62	110	49	77	8	4	13	10	0	0.125	1.000	1.000
395	METHANE_METABOLISM		ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO	13	ADH5(3), CAT(5), EPX(7), LPO(18), MPO(11), PRDX1(2), PRDX2(2), PRDX6(4), SHMT1(1), SHMT2(2), TPO(40)	3961561	95	62	92	53	74	8	1	7	5	0	0.171	1.000	1.000
396	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.	ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8	15	ACE(34), CD44(5), CSF1(10), FCGR3A(8), IL1B(6), IL6R(4), SELL(8), SPN(5), TGFB1(1), TGFB2(1), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TNFRSF8(17), TNFSF8(3)	4327349	109	62	103	46	81	5	6	5	12	0	0.0227	1.000	1.000
397	SMALL_LIGAND_GPCRS		C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R	13	C9orf47(3), CNR1(9), CNR2(4), DNMT1(18), MTNR1A(8), MTNR1B(7), PTAFR(2), PTGDR(9), PTGER2(6), PTGER4(1), PTGFR(20), PTGIR(5), TBXA2R(4)	3730498	96	62	91	70	64	12	5	7	8	0	0.330	1.000	1.000
398	TGFBPATHWAY	The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth.	APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2	13	APC(19), CDH1(5), CREBBP(20), EP300(14), MAP2K1(10), MAP3K7(1), MAPK3(1), SKIL(2), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(8)	8611661	85	62	80	42	48	8	3	14	12	0	0.865	1.000	1.000
399	AMINOACYL_TRNA_BIOSYNTHESIS		AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS	21	AARS(5), CARS(9), DARS(4), EPRS(9), FARS2(4), GARS(6), HARS(6), IARS(8), KARS(4), LARS(10), LARS2(4), MARS(6), MARS2(4), NARS(2), QARS(6), RARS(7), SARS(10), TARS(2), WARS(4), WARS2(4), YARS(1)	10796818	115	61	109	46	71	12	6	16	10	0	0.106	1.000	1.000
400	CELL2CELLPATHWAY	Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility.	ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL	13	ACTN1(5), ACTN2(21), ACTN3(7), BCAR1(4), CSK(1), CTNNA1(2), CTNNA2(23), CTNNB1(11), PTK2(8), PXN(3), SRC(1), VCL(7)	6309423	93	61	90	51	58	7	4	13	10	1	0.296	1.000	1.000
401	FREEPATHWAY	Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides.	GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH	10	GPX1(7), GSR(2), GSS(7), IL8(1), NFKB1(7), NOX1(11), RELA(4), TNF(1), XDH(50)	3303517	90	61	85	39	66	6	4	10	4	0	0.0406	1.000	1.000
402	HCMVPATHWAY	Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes.	AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1	16	AKT1(3), MAP2K1(10), MAP2K2(3), MAP2K3(7), MAP2K6(3), MAP3K1(2), MAPK1(4), MAPK14(5), MAPK3(1), NFKB1(7), PIK3CA(8), PIK3R1(3), RB1(8), RELA(4), SP1(5)	6463992	73	61	66	39	36	7	3	13	11	3	0.854	1.000	1.000
403	IGF1PATHWAY	Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types.	CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF	20	CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(3), IGF1(11), IGF1R(10), IRS1(5), JUN(1), MAP2K1(10), MAPK3(1), MAPK8(1), PIK3CA(8), PIK3R1(3), PTPN11(9), RAF1(8), RASA1(4), SHC1(1), SOS1(8), SRF(2)	8280583	92	61	83	42	46	16	2	19	8	1	0.622	1.000	1.000
404	INSULINPATHWAY	Insulin regulates glucose levels via Ras-mediated transcriptional activation.	CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF	21	CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(3), INSR(20), IRS1(5), JUN(1), MAP2K1(10), MAPK3(1), MAPK8(1), PIK3CA(8), PIK3R1(3), PTPN11(9), RAF1(8), RASA1(4), SHC1(1), SLC2A4(8), SOS1(8), SRF(2)	8565014	99	61	91	46	46	14	3	25	10	1	0.695	1.000	1.000
405	MEF2DPATHWAY	Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases.	CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@	18	CABIN1(9), CALM1(1), CALM2(1), CAPN2(6), CAPNS1(1), EP300(14), HDAC1(1), HDAC2(1), MEF2D(4), NFATC1(15), NFATC2(9), PPP3CA(5), PPP3CB(4), PPP3CC(2), PRKCA(10), SYT1(19)	8210132	102	61	97	45	70	7	7	10	8	0	0.223	1.000	1.000
406	NEUTROPHILPATHWAY	Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18.	CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL	8	CD44(5), ICAM1(2), ITGAL(24), ITGAM(21), ITGB2(13), SELE(34), SELL(8)	3432646	107	61	107	40	78	4	3	7	15	0	0.00503	1.000	1.000
407	GLUTATHIONE_METABOLISM		ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD	29	ANPEP(17), G6PD(3), GCLC(5), GCLM(2), GGT1(6), GPX1(7), GPX3(3), GPX5(12), GSS(7), GSTA1(5), GSTA2(2), GSTA3(1), GSTM1(2), GSTM2(2), GSTM3(4), GSTM4(2), GSTM5(6), GSTP1(2), GSTT1(1), IDH2(2), MGST1(2), MGST2(2), MGST3(1), PGD(7)	5751479	103	60	98	48	66	6	6	17	8	0	0.0526	1.000	1.000
408	LEPTINPATHWAY	Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity.	ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2	10	ACACA(21), CPT1A(10), LEP(2), LEPR(22), PRKAA1(1), PRKAA2(24), PRKAB1(2), PRKAB2(2), PRKAG1(2), PRKAG2(7)	4890702	93	60	87	47	65	5	4	6	13	0	0.585	1.000	1.000
409	HSA04140_REGULATION_OF_AUTOPHAGY	Genes involved in regulation of autophagy	ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3	29	ATG12(1), ATG3(1), ATG5(2), ATG7(8), BECN1(3), GABARAPL1(1), IFNA1(1), IFNA10(2), IFNA14(6), IFNA16(9), IFNA17(2), IFNA2(1), IFNA21(7), IFNA4(1), IFNA5(3), IFNA6(2), IFNA7(5), IFNA8(3), IFNG(2), PIK3C3(3), PIK3R4(6), PRKAA1(1), PRKAA2(24), ULK1(7), ULK2(6), ULK3(1)	6983276	108	59	104	57	76	7	6	13	6	0	0.429	1.000	1.000
410	IL6PATHWAY	IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation.	CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3	21	CSNK2A1(1), ELK1(2), FOS(2), GRB2(2), HRAS(3), IL6(2), IL6R(4), IL6ST(10), JAK1(6), JAK2(9), JAK3(6), JUN(1), MAP2K1(10), MAPK3(1), PTPN11(9), RAF1(8), SHC1(1), SOS1(8), SRF(2), STAT3(10)	7952718	97	59	90	46	44	12	4	25	12	0	0.735	1.000	1.000
411	N_GLYCAN_DEGRADATION		AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4	13	AGA(4), FUCA1(2), GLB1(8), HEXA(5), HEXB(4), LCT(40), MAN2C1(3), MANBA(7), NEU1(7), NEU2(14), NEU3(3), NEU4(9)	5505885	106	59	104	52	79	9	2	11	5	0	0.255	1.000	1.000
412	NDKDYNAMINPATHWAY	Endocytotic role of NDK, Phosphins and Dynamin	AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1	19	AMPH(15), AP2A1(1), AP2M1(3), BIN1(4), CALM1(1), CALM2(1), DNM1(8), EPN1(6), EPS15(3), PICALM(1), PPP3CA(5), PPP3CB(4), PPP3CC(2), SYNJ1(20), SYNJ2(15), SYT1(19)	7152216	108	59	103	53	76	9	2	16	5	0	0.386	1.000	1.000
413	CARBON_FIXATION		ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1	21	ALDOA(2), ALDOB(12), ALDOC(3), FBP1(2), FBP2(2), GOT1(6), GOT2(5), GPT(3), GPT2(1), MDH1(1), MDH2(4), ME1(19), ME2(1), ME3(9), PGK1(4), PKLR(11), PKM2(5), TKT(6)	6057530	96	58	93	49	68	8	5	7	8	0	0.0980	1.000	1.000
414	CTLA4PATHWAY	T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86.	CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@	17	CD28(1), CD3D(5), CD3E(2), CD3G(1), CD80(4), CD86(19), CTLA4(2), GRB2(2), HLA-DRA(11), HLA-DRB1(3), ICOS(3), IL2(4), ITK(20), LCK(12), PIK3CA(8), PIK3R1(3), PTPN11(9)	4276366	109	58	104	42	73	8	1	15	11	1	0.177	1.000	1.000
415	HSA00271_METHIONINE_METABOLISM	Genes involved in methionine metabolism	AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT	17	AHCY(5), BHMT(8), CBS(6), CTH(1), DNMT1(18), DNMT3A(5), DNMT3B(9), MARS(6), MARS2(4), MAT1A(5), MAT2B(2), MTAP(4), MTFMT(2), MTR(9), TAT(17)	7024338	101	58	99	40	65	6	8	12	10	0	0.0494	1.000	1.000
416	HSA00680_METHANE_METABOLISM	Genes involved in methane metabolism	ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO	10	ADH5(3), CAT(5), EPX(7), LPO(18), MPO(11), MTHFR(1), PRDX6(4), SHMT1(1), SHMT2(2), TPO(40)	3913525	92	58	89	53	72	8	1	7	4	0	0.206	1.000	1.000
417	IL3PATHWAY	IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways.	CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	15	CSF2RB(17), FOS(2), GRB2(2), HRAS(3), IL3(3), IL3RA(7), JAK2(9), MAP2K1(10), MAPK3(1), PTPN6(3), RAF1(8), SHC1(1), SOS1(8), STAT5A(2), STAT5B(4)	5870810	80	58	75	40	47	4	4	14	11	0	0.564	1.000	1.000
418	NITROGEN_METABOLISM		AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL	21	AMT(1), ASNS(8), CA1(8), CA12(3), CA2(9), CA3(5), CA4(3), CA5A(2), CA5B(1), CA6(4), CA7(1), CA8(4), CA9(8), CPS1(21), CTH(1), GLS(2), GLS2(3), GLUD1(2), GLUL(2), HAL(12)	6302036	100	58	98	44	69	6	3	13	9	0	0.148	1.000	1.000
419	SA_DIACYLGLYCEROL_SIGNALING	DAG (diacylglycerol) signaling activity	ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP	9	ESR1(5), ESR2(6), PDE1B(12), PLCB1(48), PLCB2(9), PRL(1), TRH(4), VIP(4)	3291752	89	58	83	49	74	1	2	6	6	0	0.225	1.000	1.000
420	STATIN_PATHWAY_PHARMGKB		ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1	18	ABCA1(11), APOA1(2), APOA4(7), APOC1(2), APOC2(1), APOE(1), CETP(7), CYP7A1(8), DGAT1(1), HMGCR(12), LDLR(14), LIPC(8), LPL(3), LRP1(31), SCARB1(4), SOAT1(3)	9257646	115	58	113	66	68	13	7	15	12	0	0.443	1.000	1.000
421	ATMPATHWAY	The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair.	ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73	18	ABL1(12), ATM(12), BRCA1(9), CDKN1A(4), CHEK1(2), CHEK2(3), JUN(1), MAPK8(1), MDM2(3), MRE11A(5), NFKB1(7), NFKBIA(2), RAD50(5), RBBP8(3), RELA(4), TP73(5)	9654554	78	57	77	37	35	12	4	17	10	0	0.809	1.000	1.000
422	EICOSANOID_SYNTHESIS		ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1	17	ALOX12(5), ALOX15(8), ALOX15B(8), ALOX5(8), ALOX5AP(1), DPEP1(4), GGT1(6), LTA4H(4), PLA2G2A(2), PLA2G6(9), PTGDS(2), PTGIS(12), PTGS1(17), PTGS2(10), TBXAS1(11)	4989446	107	57	104	68	77	9	2	11	8	0	0.258	1.000	1.000
423	SA_CASPASE_CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.	ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6	15	APAF1(6), BIRC2(5), BIRC3(7), CASP10(4), CASP3(2), CASP7(4), CASP8(8), CASP9(3), DFFA(2), DFFB(3), GZMB(3), PRF1(11), SCAP(8), SREBF1(5), SREBF2(8)	6091199	79	57	77	38	47	7	7	11	7	0	0.408	1.000	1.000
424	CHEMICALPATHWAY	DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis.	ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53	19	AKT1(3), APAF1(6), ATM(12), BAX(3), BCL2(2), CASP3(2), CASP7(4), CASP9(3), CYCS(1), EIF2S1(1), PRKCA(10), PTK2(8), PXN(3), STAT1(4), TLN1(12)	8859608	74	56	72	35	39	10	4	12	9	0	0.496	1.000	1.000
425	HSA03020_RNA_POLYMERASE	Genes involved in RNA polymerase	POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1	23	POLR1A(11), POLR1B(8), POLR1C(1), POLR2A(11), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLR3A(4), POLR3B(17), POLR3G(1), POLR3GL(1), POLR3H(1), POLR3K(1)	7866598	77	56	75	32	42	10	6	12	7	0	0.200	1.000	1.000
426	PENTOSE_PHOSPHATE_PATHWAY		ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT	23	ALDOA(2), ALDOB(12), ALDOC(3), FBP1(2), FBP2(2), G6PD(3), GPI(3), H6PD(5), PFKM(1), PGD(7), PGLS(1), PGM1(4), PGM3(1), PRPS1(2), PRPS1L1(13), PRPS2(3), RBKS(4), TAL1(6), TALDO1(3), TKT(6)	6828679	83	56	80	60	54	7	5	6	11	0	0.756	1.000	1.000
427	ST_TUMOR_NECROSIS_FACTOR_PATHWAY	Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun.	BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	27	BAG4(3), BIRC2(5), BIRC3(7), CASP3(2), CASP8(8), CFLAR(4), JUN(1), MAP2K4(4), MAP3K3(6), MAP3K7(1), NFKB1(7), NFKB2(4), NFKBIA(2), NFKBIB(1), NFKBIL1(3), NFKBIL2(4), NR2C2(2), RALBP1(2), RIPK1(1), TNF(1), TNFAIP3(2), TNFRSF1A(3), TNFRSF1B(3), TRAF2(2)	9040643	78	56	78	49	39	6	9	18	6	0	0.928	1.000	1.000
428	TH1TH2PATHWAY	Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils.	CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5	17	CD28(1), CD86(19), HLA-DRA(11), HLA-DRB1(3), IFNG(2), IFNGR1(4), IFNGR2(4), IL12A(3), IL12B(3), IL12RB1(15), IL12RB2(3), IL18(2), IL18R1(17), IL2(4), IL2RA(4), IL4(1), IL4R(13)	4235648	109	56	105	46	80	6	0	9	14	0	0.0898	1.000	1.000
429	RACCYCDPATHWAY	Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition.	AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1	21	AKT1(3), CCND1(1), CCNE1(4), CDK4(5), CDK6(2), CDKN1A(4), CDKN1B(1), E2F1(5), HRAS(3), MAPK1(4), MAPK3(1), NFKB1(7), NFKBIA(2), PAK1(4), PIK3CA(8), PIK3R1(3), RAF1(8), RB1(8), RELA(4), TFDP1(2)	6593952	79	55	77	36	34	7	6	17	12	3	0.435	1.000	1.000
430	ACHPATHWAY	Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway.	AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH	13	AKT1(3), CHRNB1(1), CHRNG(2), MUSK(33), PIK3CA(8), PIK3R1(3), PTK2(8), PTK2B(10), RAPSN(1), SRC(1), TERT(6)	5435909	76	54	72	64	51	4	1	14	5	1	0.981	1.000	1.000
431	N_GLYCAN_BIOSYNTHESIS		ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1	21	ALG3(4), ALG5(2), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT5(2), DDOST(2), DPAGT1(2), DPM1(1), FUT8(8), MAN1A1(15), MAN1B1(4), MGAT1(3), MGAT2(2), MGAT3(10), MGAT4A(8), MGAT4B(1), MGAT5(4), RPN2(2), ST6GAL1(5)	6688657	81	54	80	50	51	9	3	10	8	0	0.668	1.000	1.000
432	NO2IL12PATHWAY	Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II.	CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2	14	CCR5(7), CD3D(5), CD3E(2), CD3G(1), CD4(6), CXCR3(4), IFNG(2), IL12A(3), IL12B(3), IL12RB1(15), IL12RB2(3), JAK2(9), STAT4(22), TYK2(7)	4620334	89	54	87	52	56	9	4	11	9	0	0.644	1.000	1.000
433	RASPATHWAY	Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis.	AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA	20	AKT1(3), CASP9(3), CDC42(2), CHUK(2), ELK1(2), H2AFX(2), HRAS(3), MAP2K1(10), MAPK3(1), NFKB1(7), PIK3CA(8), PIK3R1(3), RAF1(8), RALA(1), RALBP1(2), RALGDS(8), RELA(4), RHOA(1)	6173856	70	54	64	41	38	10	2	15	4	1	0.848	1.000	1.000
434	TCRAPATHWAY	The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation.	CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70	10	CD3D(5), CD3E(2), CD3G(1), CD4(6), FYN(6), HLA-DRA(11), HLA-DRB1(3), LCK(12), PTPRC(30), ZAP70(8)	2953976	84	54	81	36	57	8	2	9	8	0	0.109	1.000	1.000
435	TIDPATHWAY	On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes.	DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1	16	DNAJA3(4), IFNG(2), IFNGR1(4), IFNGR2(4), IKBKB(3), JAK2(9), NFKB1(7), NFKBIA(2), RB1(8), RELA(4), TNF(1), TNFRSF1A(3), TNFRSF1B(3), USH1C(18), WT1(5)	5627065	77	54	74	33	35	6	4	13	17	2	0.400	1.000	1.000
436	CARM1PATHWAY	The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4.	CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA	13	CARM1(6), CREBBP(20), EP300(14), NCOA3(14), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), RARA(3), RXRA(4)	6930703	83	53	83	45	52	4	4	14	9	0	0.827	1.000	1.000
437	CASPASEPATHWAY	Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets.	ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1	21	APAF1(6), ARHGDIB(3), BIRC2(5), BIRC3(7), CASP1(4), CASP10(4), CASP2(1), CASP3(2), CASP4(1), CASP7(4), CASP8(8), CASP9(3), CYCS(1), DFFA(2), DFFB(3), GZMB(3), LMNA(8), LMNB1(2), LMNB2(4), PRF1(11)	6551792	82	53	82	34	44	11	6	15	6	0	0.294	1.000	1.000
438	DNA_POLYMERASE		POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS	7	POLD1(6), POLD2(2), POLE(15), POLG(8), POLL(7), POLQ(23)	5596894	61	53	60	26	33	5	2	12	9	0	0.256	1.000	1.000
439	GPCRDB_CLASS_A_RHODOPSIN_LIKE2		CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1	13	CYSLTR1(4), CYSLTR2(2), GPR109B(7), GPR161(7), GPR171(9), GPR18(5), GPR34(2), GPR39(10), GPR45(6), GPR65(10), GPR68(3), GPR75(5), GPR81(4)	3269975	74	53	72	37	53	3	4	6	8	0	0.00728	1.000	1.000
440	HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES	Genes involved in glycosphingolipid biosynthesis - ganglioseries	B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5	16	B3GALT4(2), B4GALNT1(3), GLB1(8), HEXA(5), HEXB(4), LCT(40), SLC33A1(5), ST3GAL1(6), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(5), ST6GALNAC4(1), ST6GALNAC5(7), ST6GALNAC6(2), ST8SIA1(1), ST8SIA5(9)	5516662	101	53	99	62	72	9	1	13	6	0	0.581	1.000	1.000
441	IGF1MTORPATHWAY	Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy.	AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1	18	AKT1(3), EIF2B5(1), EIF2S1(1), EIF4EBP1(1), GSK3B(2), IGF1(11), IGF1R(10), INPPL1(15), PDK2(4), PDPK1(4), PIK3CA(8), PIK3R1(3), PPP2CA(1), RPS6(1), RPS6KB1(2)	6309702	67	53	64	35	39	8	5	8	6	1	0.630	1.000	1.000
442	STRESSPATHWAY	Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs).	ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2	24	ATF1(4), CASP2(1), CHUK(2), CRADD(1), IKBKB(3), JUN(1), LTA(2), MAP2K3(7), MAP2K4(4), MAP2K6(3), MAP3K1(2), MAP3K14(3), MAP4K2(6), MAPK14(5), MAPK8(1), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), TNF(1), TNFRSF1A(3), TRAF2(2)	7951248	65	53	65	45	37	10	2	10	6	0	0.924	1.000	1.000
443	CELLCYCLEPATHWAY	Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle.	CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1	21	CCNA1(13), CCND1(1), CCND2(5), CCND3(2), CCNE1(4), CCNH(2), CDC25A(8), CDK4(5), CDK6(2), CDKN1A(4), CDKN1B(1), CDKN2C(1), E2F1(5), RB1(8), RBL1(10), TFDP1(2)	5208176	73	52	72	23	40	3	6	14	8	2	0.0243	1.000	1.000
444	EPOPATHWAY	Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia.	CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B	19	CSNK2A1(1), ELK1(2), EPO(5), EPOR(1), FOS(2), GRB2(2), HRAS(3), JAK2(9), JUN(1), MAP2K1(10), MAPK3(1), MAPK8(1), PLCG1(9), PTPN6(3), RAF1(8), SHC1(1), SOS1(8), STAT5A(2), STAT5B(4)	7124992	73	52	68	39	38	5	6	16	8	0	0.782	1.000	1.000
445	LONGEVITYPATHWAY	Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins.	AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3	13	AKT1(3), CAT(5), GH1(3), GHR(25), HRAS(3), IGF1(11), IGF1R(10), PIK3CA(8), PIK3R1(3), SHC1(1)	4439322	72	52	68	38	50	9	0	8	4	1	0.556	1.000	1.000
446	NICOTINATE_AND_NICOTINAMIDE_METABOLISM		AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT	13	AOX1(21), CD38(4), ENPP1(11), ENPP3(14), NADSYN1(4), NMNAT2(3), NNMT(9), NNT(3), NT5E(4), NT5M(2), QPRT(6)	4881343	81	52	77	38	51	8	4	9	9	0	0.317	1.000	1.000
447	PPARGPATHWAY	PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2.	CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA	7	CREBBP(20), EP300(14), LPL(3), NCOA1(9), NCOA2(13), PPARG(11), RXRA(4)	6228414	74	52	72	29	49	4	3	11	7	0	0.374	1.000	1.000
448	CREMPATHWAY	The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis.	ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1	7	ADCY1(26), FHL5(12), FSHB(4), FSHR(15), GNAS(19), XPO1(2)	3165348	78	51	75	50	58	5	4	5	6	0	0.843	1.000	1.000
449	HIFPATHWAY	Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs).	ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL	13	ARNT(7), ASPH(3), COPS5(3), EDN1(8), EP300(14), EPO(5), HIF1A(5), JUN(1), LDHA(5), NOS3(16), P4HB(2), VHL(4)	5725124	73	51	71	32	45	3	5	10	10	0	0.469	1.000	1.000
450	IGF1RPATHWAY	Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway.	AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH	15	AKT1(3), GRB2(2), HRAS(3), IGF1R(10), IRS1(5), MAP2K1(10), MAPK1(4), MAPK3(1), PIK3CA(8), PIK3R1(3), RAF1(8), SHC1(1), SOS1(8)	6366236	66	51	60	31	36	8	2	12	7	1	0.565	1.000	1.000
451	PS1PATHWAY	Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway.	ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1	12	ADAM17(1), APC(19), AXIN1(10), BTRC(4), CTNNB1(11), DLL1(2), FZD1(4), GSK3B(2), NOTCH1(6), PSEN1(1), WNT1(2)	7051430	62	51	62	38	30	7	4	7	14	0	0.908	1.000	1.000
452	TCYTOTOXICPATHWAY	Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	10	CD28(1), CD3D(5), CD3E(2), CD3G(1), CD8A(2), ICAM1(2), ITGAL(24), ITGB2(13), PTPRC(30), THY1(1)	3307115	81	51	78	42	56	5	2	5	13	0	0.200	1.000	1.000
453	THELPERPATHWAY	Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4.	CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@	10	CD28(1), CD3D(5), CD3E(2), CD3G(1), CD4(6), ICAM1(2), ITGAL(24), ITGB2(13), PTPRC(30), THY1(1)	3478666	85	51	82	48	58	6	2	6	13	0	0.323	1.000	1.000
454	UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS		ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS	20	ACY1(1), ALDH18A1(7), ARG1(1), ARG2(1), ASL(6), CKM(2), CKMT1A(1), CKMT2(5), CPS1(21), GAMT(4), GATM(5), GLUD1(2), NAGS(1), OAT(3), ODC1(3), OTC(4), PYCR1(1), SMS(5)	5779297	73	51	71	31	42	8	3	11	9	0	0.145	1.000	1.000
455	CERAMIDEPATHWAY	Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type.	BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2	21	BAX(3), BCL2(2), CASP8(8), CYCS(1), MAP2K1(10), MAP2K4(4), MAP3K1(2), MAPK1(4), MAPK3(1), MAPK8(1), NFKB1(7), NSMAF(4), RAF1(8), RELA(4), RIPK1(1), SMPD1(3), TNFRSF1A(3), TRAF2(2)	6817640	68	50	63	31	38	6	3	13	8	0	0.504	1.000	1.000
456	HSA00061_FATTY_ACID_BIOSYNTHESIS	Genes involved in fatty acid biosynthesis	ACACA, ACACB, FASN, MCAT, OLAH, OXSM	6	ACACA(21), ACACB(17), FASN(17), MCAT(2), OLAH(11), OXSM(2)	5287659	70	50	69	37	43	6	3	9	9	0	0.295	1.000	1.000
457	INFLAMPATHWAY	Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells.	CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF	29	CD4(6), CSF1(10), CSF2(2), CSF3(4), HLA-DRA(11), HLA-DRB1(3), IFNA1(1), IFNB1(6), IFNG(2), IL10(3), IL11(2), IL12A(3), IL12B(3), IL13(2), IL15(3), IL1A(4), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL7(5), IL8(1), LTA(2), PDGFA(1), TGFB1(1), TGFB2(1), TGFB3(3), TNF(1)	4398114	94	50	93	49	63	7	3	9	12	0	0.0504	1.000	1.000
458	METHIONINE_METABOLISM		AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR	12	AHCY(5), BHMT(8), CBS(6), CTH(1), DNMT1(18), DNMT3A(5), DNMT3B(9), MARS(6), MARS2(4), MAT1A(5), MAT2B(2), MTR(9)	5913932	78	50	77	26	49	4	7	10	8	0	0.0158	1.000	1.000
459	PTDINSPATHWAY	Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration.	AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2	21	AKT1(3), AP2A1(1), AP2M1(3), BTK(15), EEA1(2), GRASP(1), GSK3B(2), LYN(6), PDPK1(4), PFKL(4), PFKM(1), PLCG1(9), PRKCE(6), PRKCZ(5), RAB5A(1), RPS6KB1(2), VAV2(3)	8126485	68	50	66	44	38	5	5	10	10	0	0.672	1.000	1.000
460	RBPATHWAY	The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH	11	ATM(12), CDC25A(8), CDC25B(4), CDC25C(4), CDK4(5), CHEK1(2), MYT1(21), RB1(8), WEE1(2)	5612849	66	50	63	27	35	5	2	11	11	2	0.409	1.000	1.000
461	ST_STAT3_PATHWAY	The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors.	CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3	11	CISH(3), IL6(2), IL6R(4), JAK1(6), JAK2(9), JAK3(6), PIAS3(5), PTPRU(15), REG1A(7), SRC(1), STAT3(10)	5079781	68	50	68	40	37	6	3	12	10	0	0.659	1.000	1.000
462	TUBBYPATHWAY	Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription.	CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB	7	CHRM1(5), GNAQ(4), HTR2C(10), PLCB1(48), TUB(9)	2391755	76	50	71	36	62	1	1	7	5	0	0.129	1.000	1.000
463	ACTINYPATHWAY	The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility.	ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL	17	ACTA1(4), ACTR2(3), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), NCK1(1), NCKAP1(5), NTRK1(15), PIR(1), WASF1(4), WASF2(4), WASF3(12), WASL(5)	4986202	62	49	61	27	40	5	2	8	7	0	0.525	1.000	1.000
464	CITRATE_CYCLE_TCA_CYCLE		ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2	19	ACO1(5), ACO2(4), CS(2), DLD(2), FH(3), IDH2(2), IDH3A(3), IDH3B(1), IDH3G(2), MDH1(1), MDH2(4), PC(12), PCK1(23), SDHA(1), SDHB(1), SUCLG1(2), SUCLG2(2)	6657216	70	49	67	45	50	1	6	7	6	0	0.724	1.000	1.000
465	GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM		CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2	8	CPN2(11), CYP11A1(13), CYP11B2(13), CYP17A1(7), HSD11B1(11), HSD11B2(2), HSD3B1(10), HSD3B2(10)	2308336	77	49	73	51	57	6	1	6	7	0	0.122	1.000	1.000
466	HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS	Genes involved in polyunsaturated fatty acid biosynthesis	ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD	13	ACAA1(5), ACOX1(7), ACOX3(11), ELOVL2(2), ELOVL5(1), ELOVL6(2), FADS2(3), FASN(17), HADHA(8), HSD17B12(2), PECR(1), SCD(3)	4781218	62	49	62	29	40	4	2	9	7	0	0.0857	1.000	1.000
467	NGFPATHWAY	Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras.	CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1	18	CSNK2A1(1), DPM2(1), ELK1(2), FOS(2), GRB2(2), HRAS(3), JUN(1), KLK2(2), MAP2K1(10), MAPK3(1), MAPK8(1), NGFR(7), PIK3CA(8), PIK3R1(3), PLCG1(9), RAF1(8), SHC1(1), SOS1(8)	6362295	70	49	64	35	40	7	2	15	5	1	0.722	1.000	1.000
468	P53HYPOXIAPATHWAY	Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage.	ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53	18	ABCB1(35), AKT1(3), ATM(12), BAX(3), CDKN1A(4), CPB2(1), CSNK1A1(2), CSNK1D(1), HIC1(1), HIF1A(5), IGFBP3(2), MAPK8(1), MDM2(3), NFKBIB(1), NQO1(1)	6683490	75	49	69	41	43	8	2	12	10	0	0.854	1.000	1.000
469	PHOTOSYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR	22	ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(19), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), FDXR(8), SHMT1(1)	5371570	77	49	76	43	43	4	6	14	10	0	0.486	1.000	1.000
470	AKTPATHWAY	Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT.	AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH	14	AKT1(3), CASP9(3), CHUK(2), GH1(3), GHR(25), NFKB1(7), NFKBIA(2), PDPK1(4), PIK3CA(8), PIK3R1(3), PPP2CA(1), RELA(4)	4679510	65	48	61	38	43	6	3	8	4	1	0.832	1.000	1.000
471	ATP_SYNTHESIS		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(19), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), SHMT1(1)	5049345	69	48	68	39	38	3	6	13	9	0	0.546	1.000	1.000
472	CCR5PATHWAY	CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120.	CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1	17	CALM1(1), CALM2(1), CCL2(1), CCR5(7), CXCL12(2), CXCR4(3), FOS(2), GNAQ(4), JUN(1), MAPK14(5), MAPK8(1), PLCG1(9), PRKCA(10), PTK2B(10), SYT1(19)	4632368	76	48	71	54	50	6	4	11	5	0	0.834	1.000	1.000
473	ERK5PATHWAY	Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors.	AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1	17	AKT1(3), GRB2(2), HRAS(3), MAPK1(4), MAPK3(1), MAPK7(4), MEF2A(5), MEF2B(2), MEF2C(2), MEF2D(4), NTRK1(15), PIK3CA(8), PIK3R1(3), PLCG1(9), RPS6KA1(6), SHC1(1)	6318731	72	48	68	53	45	10	2	7	7	1	0.966	1.000	1.000
474	FLAGELLAR_ASSEMBLY		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(19), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), SHMT1(1)	5049345	69	48	68	39	38	3	6	13	9	0	0.546	1.000	1.000
475	HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS	Genes involved in chondroitin sulfate biosynthesis	B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2	15	B3GAT1(6), B3GAT2(2), B3GAT3(4), CHPF(3), CHST11(5), CHST12(4), CHST13(3), CHST14(3), CHST3(1), CHSY1(8), DSE(18), XYLT1(10), XYLT2(3)	4439467	70	48	70	46	47	9	3	7	4	0	0.461	1.000	1.000
476	HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM	Genes involved in alpha-Linolenic acid metabolism	ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6	15	ACOX1(7), ACOX3(11), FADS2(3), PLA2G12B(4), PLA2G1B(1), PLA2G2A(2), PLA2G2D(3), PLA2G2E(4), PLA2G2F(6), PLA2G3(15), PLA2G4A(11), PLA2G5(2), PLA2G6(9)	3390359	78	48	78	42	56	5	1	5	11	0	0.241	1.000	1.000
477	HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION	Genes involved in naphthalene and anthracene degradation	CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	18	CARM1(6), DHRS1(3), DHRS2(6), DHRS3(4), DHRS7(1), DHRSX(4), HEMK1(4), LCMT1(4), METTL2B(7), METTL6(2), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), WBSCR22(1)	5049976	66	48	65	33	38	9	2	13	4	0	0.366	1.000	1.000
478	HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION	Genes involved in benzoate degradation via CoA ligation	ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1	24	ACAT2(1), ACOT11(6), DHRS1(3), DHRS2(6), DHRS3(4), DHRS7(1), DHRSX(4), ECHS1(2), EHHADH(6), ESCO1(1), ESCO2(2), GCDH(5), HADHA(8), MYST3(15), MYST4(14), NAT6(2), PNPLA3(2), SH3GLB1(2), YOD1(1)	8743384	85	48	83	57	50	10	3	17	5	0	0.976	1.000	1.000
479	IL22BPPATHWAY	IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes.	IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2	13	IL10RA(7), IL22(1), IL22RA1(11), IL22RA2(1), JAK1(6), JAK2(9), JAK3(6), SOCS3(2), STAT1(4), STAT3(10), STAT5A(2), STAT5B(4), TYK2(7)	6090468	70	48	70	43	36	6	7	14	7	0	0.823	1.000	1.000
480	SA_PTEN_PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.	AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1	15	AKT1(3), AKT2(8), AKT3(4), GRB2(2), MAPK1(4), MAPK3(1), PDK1(2), PIK3CA(8), PIK3CD(7), PTK2B(10), RBL2(4), SHC1(1), SOS1(8)	6606606	62	48	61	34	36	6	0	14	6	0	0.775	1.000	1.000
481	TYPE_III_SECRETION_SYSTEM		ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H	21	ATP5O(5), ATP6AP1(2), ATP6V0A1(9), ATP6V0A4(19), ATP6V1A(3), ATP6V1B1(5), ATP6V1B2(3), ATP6V1C2(8), ATP6V1E1(1), ATP6V1F(1), ATP6V1G2(1), ATP6V1G3(6), ATP6V1H(5), SHMT1(1)	5049345	69	48	68	39	38	3	6	13	9	0	0.546	1.000	1.000
482	41BBPATHWAY	TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells.	ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2	18	ATF2(5), CHUK(2), IFNG(2), IKBKB(3), IL2(4), IL4(1), JUN(1), MAP3K1(2), MAP3K5(16), MAP4K5(3), MAPK14(5), MAPK8(1), NFKB1(7), NFKBIA(2), RELA(4), TNFRSF9(4), TNFSF9(1), TRAF2(2)	6407070	65	47	62	33	38	5	1	12	9	0	0.658	1.000	1.000
483	ARFPATHWAY	Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest.	ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1	13	ABL1(12), E2F1(5), MDM2(3), MYC(5), PIK3CA(8), PIK3R1(3), POLR1A(11), POLR1B(8), POLR1C(1), RB1(8), TBX2(6), TWIST1(1)	6158354	71	47	70	21	42	8	2	9	7	3	0.0169	1.000	1.000
484	MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION		ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20	15	ACADL(4), ACADM(5), ACADS(4), ACADVL(1), ACSL1(4), ACSL3(6), ACSL4(2), CPT1A(10), CPT2(1), DCI(2), EHHADH(6), HADHA(8), PECR(1), SCP2(2), SLC25A20(1)	5687170	57	47	54	30	38	3	3	7	6	0	0.711	1.000	1.000
485	P53PATHWAY	p53 induces cell cycle arrest or apoptosis under conditions of DNA damage.	APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53	15	APAF1(6), ATM(12), BAX(3), BCL2(2), CCND1(1), CCNE1(4), CDK4(5), CDKN1A(4), E2F1(5), MDM2(3), PCNA(2), RB1(8), TIMP3(5)	5757379	60	47	58	18	21	7	4	14	12	2	0.139	1.000	1.000
486	ST_JAK_STAT_PATHWAY	The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation.	CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1	9	CISH(3), JAK1(6), JAK2(9), JAK3(6), PIAS1(5), PIAS3(5), PTPRU(15), REG1A(7), SOAT1(3)	4569654	59	47	59	28	37	4	2	8	8	0	0.335	1.000	1.000
487	AMINOSUGARS_METABOLISM		CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1	15	CMAS(1), GCK(17), GFPT1(4), GNE(3), HEXA(5), HEXB(4), HK1(3), HK2(12), HK3(13), PGM3(1), RENBP(3), UAP1(2)	5683967	68	46	65	38	46	5	2	8	7	0	0.517	1.000	1.000
488	CTLPATHWAY	Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways.	B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@	10	B2M(5), CD3D(5), CD3E(2), CD3G(1), GZMB(3), HLA-A(6), ICAM1(2), ITGAL(24), ITGB2(13), PRF1(11)	2909979	72	46	70	31	43	7	3	5	14	0	0.0621	1.000	1.000
489	HSA00902_MONOTERPENOID_BIOSYNTHESIS	Genes involved in monoterpenoid biosynthesis	CYP2C19, CYP2C9	2	CYP2C19(35), CYP2C9(35)	675777	70	46	62	47	59	3	2	1	5	0	0.675	1.000	1.000
490	PMLPATHWAY	Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis.	CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1	12	CREBBP(20), DAXX(9), HRAS(3), PAX3(3), PML(3), RARA(3), RB1(8), SP100(8), TNF(1), TNFRSF1A(3), TNFRSF1B(3)	6013662	64	46	64	28	28	8	6	11	9	2	0.420	1.000	1.000
491	STEROID_BIOSYNTHESIS		CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2	9	CYP17A1(7), F13B(23), HSD17B2(9), HSD17B3(5), HSD17B4(6), HSD17B7(1), HSD3B1(10), HSD3B2(10)	2678975	71	46	66	32	50	4	5	4	7	1	0.109	1.000	1.000
492	ARAPPATHWAY	ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's.	ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4	12	ARFGAP1(4), ARFGAP3(3), ARFGEF2(15), CLTA(1), CLTB(1), COPA(6), GBF1(12), GPLD1(20), KDELR3(1)	5491871	63	45	63	38	35	5	4	13	6	0	0.817	1.000	1.000
493	CACAMPATHWAY	Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB.	CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1	14	CALM1(1), CALM2(1), CAMK1(4), CAMK1G(9), CAMK2A(4), CAMK2B(4), CAMK2D(6), CAMK2G(4), CAMK4(10), CAMKK1(3), CAMKK2(7), SYT1(19)	3889849	72	45	67	57	53	7	2	6	4	0	0.906	1.000	1.000
494	CDC42RACPATHWAY	PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers.	ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL	13	ACTR2(3), ACTR3(2), ARPC1B(3), ARPC2(1), ARPC3(1), ARPC4(1), CDC42(2), PAK1(4), PDGFRA(27), PIK3CA(8), PIK3R1(3), WASL(5)	4363245	60	45	59	23	38	3	2	8	8	1	0.318	1.000	1.000
495	GLYCOSAMINOGLYCAN_DEGRADATION		ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU	11	ARSB(1), GALNS(4), GLB1(8), GNS(2), GUSB(3), HEXA(5), HEXB(4), IDS(9), IDUA(4), LCT(40), NAGLU(4)	4783621	84	45	82	46	66	5	0	8	5	0	0.406	1.000	1.000
496	HSA03010_RIBOSOME	Genes involved in ribosome	C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23	67	MRPL13(1), MRPS7(1), RPL10L(6), RPL11(2), RPL13A(2), RPL14(1), RPL18(3), RPL18A(1), RPL19(1), RPL21(1), RPL26(1), RPL27(3), RPL27A(1), RPL29(1), RPL3(2), RPL30(1), RPL32(1), RPL35(1), RPL36AL(1), RPL38(1), RPL39(1), RPL3L(3), RPL6(1), RPL7(2), RPS10(1), RPS11(1), RPS13(1), RPS16(1), RPS18(1), RPS2(2), RPS20(2), RPS23(1), RPS24(1), RPS27(1), RPS29(1), RPS3A(1), RPS5(1), RPS6(1), RPS7(4), RPS8(1), RPSA(1)	7542160	61	45	61	41	33	5	7	10	6	0	0.856	1.000	1.000
497	HSP27PATHWAY	Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis.	ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6	15	ACTA1(4), APAF1(6), BCL2(2), CASP3(2), CASP9(3), CYCS(1), DAXX(9), FAS(5), FASLG(14), HSPB1(2), HSPB2(1), IL1A(4), MAPKAPK2(7), MAPKAPK3(3), TNF(1)	3812619	64	45	63	29	39	4	3	8	10	0	0.264	1.000	1.000
498	AKAPCENTROSOMEPATHWAY	Protein Kinase A at the Centrosome	AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1	10	AKAP9(27), MAP2(13), PPP1CA(1), PPP2CA(1), PRKACB(4), PRKACG(8), PRKAG1(2), PRKAR2A(1), PRKAR2B(5), PRKCE(6)	6055010	68	44	67	42	40	7	4	8	9	0	0.952	1.000	1.000
499	FEEDERPATHWAY	Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis.	HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH	9	HK1(3), KHK(1), LCT(40), MPI(1), PGM1(4), PYGL(7), PYGM(10), TREH(3)	4416819	69	44	68	56	54	6	1	5	3	0	0.789	1.000	1.000
500	IL5PATHWAY	Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow.	CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6	10	CCL11(1), CCR3(10), CD4(6), HLA-DRA(11), HLA-DRB1(3), IL1B(6), IL4(1), IL5(4), IL5RA(12), IL6(2)	1787952	56	44	53	33	43	1	1	5	6	0	0.221	1.000	1.000
501	TALL1PATHWAY	APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation.	CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6	15	CHUK(2), MAP3K14(3), MAPK14(5), MAPK8(1), NFKB1(7), RELA(4), TNFRSF13B(8), TNFRSF17(6), TNFSF13B(1), TRAF2(2), TRAF3(5), TRAF5(7), TRAF6(4)	4808832	55	44	54	26	35	6	0	11	3	0	0.447	1.000	1.000
502	ERBB3PATHWAY	Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation.	EGF, EGFR, ERBB3, NRG1, UBE2D1	5	EGF(18), EGFR(22), ERBB3(5), NRG1(14), UBE2D1(1)	3462760	60	43	60	40	45	1	3	7	4	0	0.965	1.000	1.000
503	GATA3PATHWAY	GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13.	GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	16	GATA3(8), IL13(2), IL4(1), IL5(4), MAF(1), MAP2K3(7), MAPK14(5), NFATC1(15), NFATC2(9), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5)	4032673	74	43	72	47	51	8	3	5	7	0	0.601	1.000	1.000
504	HSA00670_ONE_CARBON_POOL_BY_FOLATE	Genes involved in one carbon pool by folate	ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	16	ALDH1L1(14), AMT(1), ATIC(5), FTCD(2), GART(9), MTFMT(2), MTHFD1(10), MTHFD1L(1), MTHFD2(2), MTHFR(1), MTR(9), SHMT1(1), SHMT2(2), TYMS(1)	6348907	60	43	59	37	39	5	3	6	7	0	0.751	1.000	1.000
505	HSA04710_CIRCADIAN_RHYTHM	Genes involved in circadian rhythm	ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3	11	ARNTL(6), CLOCK(4), CRY1(7), CRY2(3), CSNK1D(1), CSNK1E(4), NPAS2(4), PER1(8), PER2(11), PER3(9)	5694130	57	43	54	41	37	6	1	4	9	0	0.962	1.000	1.000
506	LIMONENE_AND_PINENE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS	12	ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2), ECHS1(2), EHHADH(6), HADHA(8), SDS(2)	4058870	56	43	54	31	31	9	2	9	5	0	0.425	1.000	1.000
507	RELAPATHWAY	Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB.	CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6	15	CHUK(2), CREBBP(20), EP300(14), HDAC3(5), IKBKB(3), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF6(4)	7465499	69	43	69	35	40	7	5	12	5	0	0.661	1.000	1.000
508	TRKAPATHWAY	Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway.	AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1	12	AKT1(3), DPM2(1), GRB2(2), HRAS(3), KLK2(2), NTRK1(15), PIK3CA(8), PIK3R1(3), PLCG1(9), PRKCA(10), SHC1(1), SOS1(8)	5202210	65	43	63	33	40	8	2	9	5	1	0.645	1.000	1.000
509	CDC25PATHWAY	The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase.	ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH	8	ATM(12), CDC25A(8), CDC25B(4), CDC25C(4), CHEK1(2), MYT1(21), WEE1(2)	4612621	53	42	51	26	34	5	1	6	7	0	0.662	1.000	1.000
510	HSA00440_AMINOPHOSPHONATE_METABOLISM	Genes involved in aminophosphonate metabolism	CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22	16	CARM1(6), CHPT1(1), HEMK1(4), LCMT1(4), METTL2B(7), METTL6(2), PCYT1A(3), PCYT1B(7), PRMT2(2), PRMT3(5), PRMT5(6), PRMT6(1), PRMT7(2), PRMT8(8), WBSCR22(1)	4704823	59	42	58	24	34	7	4	10	4	0	0.149	1.000	1.000
511	HSA00533_KERATAN_SULFATE_BIOSYNTHESIS	Genes involved in keratan sulfate biosynthesis	B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	16	B3GNT1(2), B3GNT2(2), B3GNT7(4), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), CHST1(9), CHST2(4), CHST4(9), CHST6(4), FUT8(8), ST3GAL1(6), ST3GAL2(1), ST3GAL3(1), ST3GAL4(1)	4165088	60	42	59	38	39	12	4	2	3	0	0.448	1.000	1.000
512	PTENPATHWAY	PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K.	AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6	15	AKT1(3), BCAR1(4), CDKN1B(1), GRB2(2), ITGB1(4), MAPK1(4), MAPK3(1), PDK2(4), PDPK1(4), PIK3CA(8), PIK3R1(3), PTK2(8), SHC1(1), SOS1(8)	6146858	55	42	53	30	34	5	0	10	5	1	0.840	1.000	1.000
513	ST_TYPE_I_INTERFERON_PATHWAY	Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response.	IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2	8	IFNAR1(2), IFNB1(6), JAK1(6), PTPRU(15), REG1A(7), STAT1(4), STAT2(8), TYK2(7)	4197615	55	42	55	28	29	4	2	10	10	0	0.397	1.000	1.000
514	ALKALOID_BIOSYNTHESIS_II		ABP1, AOC2, AOC3, CES1, ESD	5	ABP1(18), AOC2(7), AOC3(8), CES1(16), ESD(2)	2014132	51	41	49	34	41	2	4	2	2	0	0.622	1.000	1.000
515	HSA00100_BIOSYNTHESIS_OF_STEROIDS	Genes involved in biosynthesis of steroids	CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1	24	CYP27B1(1), CYP51A1(1), DHCR24(1), DHCR7(9), FDPS(3), GGCX(3), GGPS1(1), HMGCR(12), HSD17B7(1), IDI1(1), IDI2(1), LSS(2), MVD(1), MVK(2), NQO1(1), NSDHL(3), PMVK(2), SC4MOL(3), SC5DL(2), SQLE(4), TM7SF2(4)	6454179	58	41	56	31	26	11	4	10	7	0	0.533	1.000	1.000
516	HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - neo-lactoseries	ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1	20	ABO(6), B3GNT1(2), B3GNT2(2), B3GNT3(6), B3GNT4(3), B3GNT5(1), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT4(3), FUT1(3), FUT2(3), FUT3(4), FUT4(2), FUT5(6), FUT6(4), FUT7(2), ST3GAL6(2), ST8SIA1(1)	5105704	56	41	55	33	33	8	3	3	9	0	0.443	1.000	1.000
517	D4GDIPATHWAY	D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3.	ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1	12	APAF1(6), ARHGAP5(11), ARHGDIB(3), CASP1(4), CASP10(4), CASP3(2), CASP8(8), CASP9(3), CYCS(1), GZMB(3), JUN(1), PRF1(11)	4333637	57	40	56	28	36	6	3	9	3	0	0.642	1.000	1.000
518	EEA1PATHWAY	The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system.	EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC	7	EEA1(2), EGF(18), EGFR(22), HGS(3), RAB5A(1), TF(11), TFRC(4)	4297461	61	40	61	41	43	2	4	8	4	0	0.946	1.000	1.000
519	MITRPATHWAY	The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR.	CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH	9	CAMK1(4), CAMK1G(9), HDAC9(38), MEF2A(5), MEF2B(2), MEF2C(2), MEF2D(4), MYOD1(1)	2478754	65	40	57	32	52	5	0	3	5	0	0.326	1.000	1.000
520	ONE_CARBON_POOL_BY_FOLATE		ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS	15	ALDH1L1(14), AMT(1), ATIC(5), GART(9), MTHFD1(10), MTHFD1L(1), MTHFD2(2), MTHFR(1), MTR(9), SHMT1(1), SHMT2(2), TYMS(1)	5995111	56	40	55	32	36	5	3	6	6	0	0.597	1.000	1.000
521	CYTOKINEPATHWAY	Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response.	IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF	20	IFNA1(1), IFNB1(6), IFNG(2), IL10(3), IL12A(3), IL12B(3), IL13(2), IL15(3), IL16(12), IL18(2), IL1A(4), IL2(4), IL3(3), IL4(1), IL5(4), IL6(2), IL8(1), IL9(1), LTA(2), TNF(1)	3306170	60	39	59	34	41	3	3	4	9	0	0.229	1.000	1.000
522	EPONFKBPATHWAY	The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB.	ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2	11	ARNT(7), CDKN1A(4), EPO(5), EPOR(1), GRIN1(7), HIF1A(5), JAK2(9), NFKB1(7), NFKBIA(2), RELA(4)	4194201	51	39	51	23	21	5	5	10	10	0	0.575	1.000	1.000
523	HYPERTROPHY_MODEL		ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1	17	ADAM10(7), ANKRD1(1), CYR61(1), DUSP14(2), EIF4EBP1(1), HBEGF(1), IFNG(2), IFRD1(2), IL18(2), IL1A(4), IL1R1(11), JUND(1), MYOG(3), NR4A3(7), WDR1(4)	3557358	49	39	47	23	31	5	2	4	7	0	0.451	1.000	1.000
524	PELP1PATHWAY	Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors.	CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC	7	CREBBP(20), EP300(14), ESR1(5), MAPK1(4), MAPK3(1), PELP1(11), SRC(1)	4908328	56	39	56	29	36	3	4	9	4	0	0.676	1.000	1.000
525	SELENOAMINO_ACID_METABOLISM		AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1	12	AHCY(5), CBS(6), CTH(1), GGT1(6), MARS(6), MARS2(4), MAT1A(5), MAT2B(2), PAPSS1(3), PAPSS2(5), SCLY(3), SEPHS1(4)	4180628	50	39	50	21	31	4	3	7	5	0	0.118	1.000	1.000
526	ACETAMINOPHENPATHWAY	Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver.	CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2	5	CYP1A2(10), CYP2E1(13), NR1I3(7), PTGS1(17), PTGS2(10)	1806954	57	38	55	31	42	4	1	4	6	0	0.203	1.000	1.000
527	AGPCRPATHWAY	G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis.	ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1	11	ARRB1(3), GNAS(19), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5), PRKCA(10)	3165103	54	38	52	39	42	4	2	2	4	0	0.944	1.000	1.000
528	HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM	Genes involved in glyoxylate and dicarboxylate metabolism	ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	13	ACO1(5), ACO2(4), AFMID(2), CS(2), GRHPR(2), HAO1(7), HAO2(11), HYI(1), MDH1(1), MDH2(4), MTHFD1(10), MTHFD1L(1), MTHFD2(2)	4489553	52	38	49	27	30	4	4	6	8	0	0.355	1.000	1.000
529	IL10PATHWAY	The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1.	BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF	13	BLVRA(2), BLVRB(1), HMOX1(1), IL10(3), IL10RA(7), IL10RB(5), IL1A(4), IL6(2), JAK1(6), STAT1(4), STAT3(10), STAT5A(2), TNF(1)	4089982	48	38	47	26	22	5	6	7	8	0	0.479	1.000	1.000
530	IL4PATHWAY	IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways.	AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6	11	AKT1(3), GRB2(2), IL2RG(3), IL4(1), IL4R(13), IRS1(5), JAK1(6), JAK3(6), RPS6KB1(2), SHC1(1), STAT6(7)	4937568	49	38	49	26	28	6	3	5	7	0	0.503	1.000	1.000
531	SETPATHWAY	Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis.	ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET	11	ANP32A(3), CREBBP(20), DFFA(2), DFFB(3), GZMA(11), GZMB(3), HMGB2(1), PRF1(11), SET(3)	3553310	57	38	55	19	33	4	5	10	5	0	0.115	1.000	1.000
532	TNFR2PATHWAY	Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3	17	CHUK(2), IKBKAP(5), IKBKB(3), LTA(2), MAP3K1(2), MAP3K14(3), NFKB1(7), NFKBIA(2), RELA(4), RIPK1(1), TNFAIP3(2), TNFRSF1B(3), TRAF1(6), TRAF2(2), TRAF3(5)	7459302	49	38	49	47	31	6	1	6	5	0	0.999	1.000	1.000
533	ACETYLCHOLINE_SYNTHESIS		ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3	8	ACHE(6), CHAT(14), CHKA(2), PCYT1A(3), PDHA1(3), PDHA2(17), PEMT(2), SLC18A3(2)	2296468	49	37	46	23	39	5	0	2	3	0	0.0943	1.000	1.000
534	DREAMPATHWAY	The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling.	CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B	13	FOS(2), JUN(1), MAPK3(1), OPRK1(21), POLR2A(11), PRKACB(4), PRKACG(8), PRKAR1A(1), PRKAR1B(3), PRKAR2A(1), PRKAR2B(5)	4294432	58	37	58	54	45	3	3	3	4	0	0.987	1.000	1.000
535	HSA00363_BISPHENOL_A_DEGRADATION	Genes involved in bisphenol A degradation	AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14	14	AKR1B10(8), DHRS1(3), DHRS2(6), DHRS3(4), DHRS7(1), DHRSX(4), HSD3B7(3), PON1(14), PON2(1), PON3(5), RDH11(2), RDH12(2), RDH13(3)	3030336	56	37	54	29	39	4	1	7	5	0	0.249	1.000	1.000
536	RANKLPATHWAY	RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts.	FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6	12	FOS(2), FOSL2(5), IFNAR1(2), IFNAR2(7), IFNB1(6), MAPK8(1), NFKB1(7), RELA(4), TNFRSF11A(5), TNFSF11(4), TRAF6(4)	3708288	47	37	46	24	30	3	0	9	5	0	0.635	1.000	1.000
537	S1PPATHWAY	At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis.	EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2	7	HMGCS1(2), LDLR(14), MBTPS1(9), MBTPS2(1), SCAP(8), SREBF1(5), SREBF2(8)	3968538	47	37	45	25	30	2	3	8	4	0	0.468	1.000	1.000
538	CHOLESTEROL_BIOSYNTHESIS		C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE	15	CYP51A1(1), DHCR7(9), FDPS(3), HMGCR(12), HMGCS1(2), IDI1(1), LSS(2), MVD(1), MVK(2), NSDHL(3), PMVK(2), SC4MOL(3), SC5DL(2), SQLE(4)	4409973	47	36	45	22	21	8	2	10	6	0	0.493	1.000	1.000
539	GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM		ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2	12	ACO1(5), ACO2(4), CS(2), GRHPR(2), HAO1(7), HAO2(11), HYI(1), MDH1(1), MDH2(4), MTHFD1(10), MTHFD1L(1), MTHFD2(2)	4286373	50	36	47	23	29	4	3	6	8	0	0.221	1.000	1.000
540	HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM	Genes involved in taurine and hypotaurine metabolism	BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4	6	BAAT(10), CDO1(5), CSAD(4), GAD1(13), GAD2(7), GGT1(6)	1895413	45	36	44	25	30	4	4	5	2	0	0.448	1.000	1.000
541	HSA00521_STREPTOMYCIN_BIOSYNTHESIS	Genes involved in streptomycin biosynthesis	GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS	10	GCK(17), HK1(3), HK2(12), HK3(13), IMPA1(1), IMPA2(2), ISYNA1(1), PGM1(4), PGM3(1), TGDS(1)	3900255	55	36	53	35	40	5	1	4	5	0	0.539	1.000	1.000
542	HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT	Genes involved in SNARE interactions in vesicular transport	BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6	35	BET1(1), BET1L(1), BNIP1(1), GOSR1(1), SEC22B(5), SNAP25(6), SNAP29(1), STX10(1), STX11(1), STX12(1), STX16(2), STX17(1), STX19(2), STX2(4), STX3(2), STX5(4), STX6(1), TSNARE1(4), VAMP1(1), VAMP3(1), VAMP4(1), VAMP7(5), VAMP8(1), VTI1A(1), VTI1B(1)	5540826	50	36	47	26	28	5	1	9	7	0	0.492	1.000	1.000
543	ST_INTERFERON_GAMMA_PATHWAY	The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors.	CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1	9	CISH(3), IFNG(2), IFNGR1(4), JAK1(6), JAK2(9), PLA2G2A(2), PTPRU(15), REG1A(7), STAT1(4)	3823924	52	36	52	22	30	2	1	9	10	0	0.339	1.000	1.000
544	CD40PATHWAY	The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand.	CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6	12	CHUK(2), IKBKAP(5), IKBKB(3), MAP3K1(2), MAP3K14(3), NFKB1(7), NFKBIA(2), RELA(4), TNFAIP3(2), TRAF3(5), TRAF6(4)	6040771	39	35	39	33	23	6	1	6	3	0	0.990	1.000	1.000
545	CHONDROITIN		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(4), HS3ST1(10), HS3ST2(7), HS3ST3A1(4), HS3ST3B1(2), XYLT1(10), XYLT2(3)	2125078	40	35	40	37	25	5	1	5	4	0	0.907	1.000	1.000
546	HEPARAN_SULFATE_BIOSYNTHESIS		B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2	8	B3GAT3(4), HS3ST1(10), HS3ST2(7), HS3ST3A1(4), HS3ST3B1(2), XYLT1(10), XYLT2(3)	2125078	40	35	40	37	25	5	1	5	4	0	0.907	1.000	1.000
547	HSA00920_SULFUR_METABOLISM	Genes involved in sulfur metabolism	BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX	12	CHST11(5), CHST12(4), CHST13(3), PAPSS1(3), PAPSS2(5), SULT1A1(12), SULT1A2(2), SULT1E1(12), SULT2A1(7), SULT2B1(6), SUOX(4)	3049991	63	35	61	35	51	3	0	4	5	0	0.338	1.000	1.000
548	RNA_POLYMERASE		POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT	14	POLR1B(8), POLR2A(11), POLR2B(11), POLR2C(1), POLR2D(1), POLR2E(3), POLR2F(1), POLR2H(2), POLR2J(1), POLR2L(1), POLRMT(2)	4477860	42	35	41	16	25	4	2	6	5	0	0.142	1.000	1.000
549	SARSPATHWAY	The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro.	ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL	10	ANPEP(17), CKM(2), FBL(1), GPT(3), LDHA(5), LDHB(2), LDHC(5), MAPK14(5), NCL(6)	3010319	46	35	45	22	32	2	4	5	3	0	0.358	1.000	1.000
550	ST_IL_13_PATHWAY	Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(3), IL13RA2(3), IL4R(13), JAK1(6), JAK2(9), TYK2(7)	3501773	43	35	43	21	26	2	2	8	5	0	0.605	1.000	1.000
551	ST_INTERLEUKIN_13_PATHWAY	IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor.	IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2	7	IL13(2), IL13RA1(3), IL13RA2(3), IL4R(13), JAK1(6), JAK2(9), TYK2(7)	3501773	43	35	43	21	26	2	2	8	5	0	0.605	1.000	1.000
552	TSP1PATHWAY	Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells.	CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1	7	CASP3(2), CD36(4), FOS(2), FYN(6), JUN(1), MAPK14(5), THBS1(27)	2480709	47	35	47	27	28	1	2	7	9	0	0.775	1.000	1.000
553	HSA00642_ETHYLBENZENE_DEGRADATION	Genes involved in ethylbenzene degradation	ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1	12	DHRS1(3), DHRS2(6), DHRS3(4), DHRS7(1), DHRSX(4), ESCO1(1), ESCO2(2), MYST3(15), MYST4(14), NAT6(2), PNPLA3(2), SH3GLB1(2)	5581995	56	34	55	41	32	7	1	12	4	0	0.992	1.000	1.000
554	STREPTOMYCIN_BIOSYNTHESIS		GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS	8	GCK(17), HK1(3), HK2(12), HK3(13), IMPA1(1), PGM1(4), PGM3(1), TGDS(1)	3428477	52	34	50	30	39	5	1	3	4	0	0.400	1.000	1.000
555	GSPATHWAY	Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways.	ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A	6	ADCY1(26), GNAS(19), PRKACA(3), PRKAR1A(1)	2172718	49	33	47	26	32	5	3	4	5	0	0.394	1.000	1.000
556	PLK3PATHWAY	Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis.	ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH	6	ATM(12), ATR(20), CDC25C(4), CHEK1(2), CHEK2(3)	5080244	41	33	40	21	26	2	3	5	5	0	0.836	1.000	1.000
557	AKAP13PATHWAY	A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac.	AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B	7	AKAP13(19), GNA12(3), PRKACB(4), PRKACG(8), PRKAG1(2), PRKAR2A(1), PRKAR2B(5)	3379191	42	31	42	26	30	3	1	5	3	0	0.771	1.000	1.000
558	HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES	Genes involved in glycosphingolipid biosynthesis - globoseries	A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1	13	A4GALT(5), B3GALNT1(6), B3GALT5(1), FUT1(3), FUT2(3), GBGT1(2), GLA(1), HEXA(5), HEXB(4), NAGA(3), ST3GAL1(6), ST3GAL2(1), ST8SIA1(1)	3367220	41	31	40	32	26	4	2	5	4	0	0.857	1.000	1.000
559	IFNAPATHWAY	Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2.	IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2	8	IFNA1(1), IFNAR1(2), IFNAR2(7), IFNB1(6), JAK1(6), STAT1(4), STAT2(8), TYK2(7)	3610515	41	31	41	19	21	3	2	9	6	0	0.450	1.000	1.000
560	IL17PATHWAY	Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines.	CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@	12	CD34(4), CD3D(5), CD3E(2), CD3G(1), CD4(6), CD58(1), CD8A(2), CSF3(4), IL3(3), IL6(2), IL8(1), KITLG(8)	1812386	39	31	38	23	28	2	2	5	2	0	0.458	1.000	1.000
561	P35ALZHEIMERSPATHWAY	p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis.	APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA	11	APP(9), CAPN1(4), CAPNS1(1), CDK5(4), CSNK1A1(2), CSNK1D(1), GSK3B(2), MAPT(10), PPP2CA(1)	3012036	34	31	34	16	22	2	2	3	5	0	0.349	1.000	1.000
562	BIOSYNTHESIS_OF_STEROIDS		DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1	14	DHCR7(9), FDPS(3), HMGCR(12), IDI1(1), LSS(2), MVD(1), MVK(2), NQO1(1), PMVK(2), SC5DL(2), SQLE(4)	3690312	39	30	37	20	16	6	2	10	5	0	0.625	1.000	1.000
563	HSA03050_PROTEASOME	Genes involved in proteasome	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6	22	PSMA1(5), PSMA2(1), PSMA4(1), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC2(2), PSMC3(4), PSMD1(5), PSMD12(1), PSMD13(3), PSMD2(3)	5410945	39	30	38	19	22	4	2	8	3	0	0.685	1.000	1.000
564	TOB1PATHWAY	TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression.	CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@	16	CD28(1), CD3D(5), CD3E(2), CD3G(1), IFNG(2), IL2(4), IL2RA(4), IL4(1), TGFB1(1), TGFB2(1), TGFB3(3), TGFBR2(8), TGFBR3(6), TOB1(2), TOB2(2)	3525657	43	30	43	25	34	2	0	1	6	0	0.523	1.000	1.000
565	UBIQUITIN_MEDIATED_PROTEOLYSIS		CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A	23	CDC34(4), NRF1(4), UBE2D1(1), UBE2D3(3), UBE2E1(1), UBE2E3(1), UBE2G2(1), UBE2H(1), UBE2I(2), UBE2J1(2), UBE2J2(6), UBE2L6(2), UBE2M(1), UBE2S(2), UBE3A(6)	3546056	37	30	36	17	24	5	1	5	2	0	0.538	1.000	1.000
566	1_2_DICHLOROETHANE_DEGRADATION		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2)	2661393	38	29	37	24	20	7	2	5	4	0	0.593	1.000	1.000
567	ASCORBATE_AND_ALDARATE_METABOLISM		ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1	8	ALDH1A1(4), ALDH1A2(11), ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH9A1(2)	2661393	38	29	37	24	20	7	2	5	4	0	0.593	1.000	1.000
568	NUCLEOTIDE_GPCRS		ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6	8	ADORA1(6), ADORA2A(2), ADORA2B(1), ADORA3(12), LTB4R(1), P2RY1(4), P2RY2(8), P2RY6(1)	1995771	35	29	35	28	22	5	0	5	3	0	0.329	1.000	1.000
569	STAT3PATHWAY	The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling.	FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2	7	JAK1(6), JAK2(9), JAK3(6), MAPK1(4), MAPK3(1), STAT3(10), TYK2(7)	3894052	43	29	43	31	20	5	3	8	7	0	0.929	1.000	1.000
570	EIF2PATHWAY	Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process.	EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR	9	EIF2AK3(17), EIF2AK4(13), EIF2B5(1), EIF2S1(1), EIF5(1), GSK3B(2), PPP1CA(1)	3901306	36	28	32	15	16	1	1	12	6	0	0.760	1.000	1.000
571	GLYCOLYSISPATHWAY	Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP.	ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1	9	ALDOB(12), ENO1(4), GPI(3), HK1(3), PFKL(4), PGK1(4), PKLR(11)	3073161	41	28	38	17	28	4	1	4	4	0	0.0350	1.000	1.000
572	HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM	Genes involved in ascorbate and aldarate metabolism	ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH	9	ALDH1A3(2), ALDH1B1(8), ALDH2(4), ALDH3A1(5), ALDH3A2(2), ALDH7A1(9), ALDH9A1(2), MIOX(3), UGDH(1)	2834324	36	28	34	26	19	7	4	3	3	0	0.784	1.000	1.000
573	MTA3PATHWAY	The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer.	ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8	10	ALDOA(2), CTSD(3), ESR1(5), GREB1(18), HSPB1(2), HSPB2(1), MTA1(2), MTA3(2), PDZK1(3), TUBA8(3)	3569272	41	28	40	26	30	2	3	4	2	0	0.549	1.000	1.000
574	SRCRPTPPATHWAY	Activation of Src by Protein-tyrosine phosphatase alpha	CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC	9	CDC25A(8), CDC25B(4), CDC25C(4), CSK(1), GRB2(2), PRKCA(10), PTPRA(7), SRC(1)	3114858	37	28	36	23	24	6	1	4	2	0	0.705	1.000	1.000
575	ASBCELLPATHWAY	B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response.	CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	8	CD28(1), CD4(6), CD80(4), HLA-DRA(11), HLA-DRB1(3), IL10(3), IL2(4), IL4(1)	1320155	33	26	33	20	21	1	1	6	4	0	0.435	1.000	1.000
576	CIRCADIANPATHWAY	A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry.	ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1	6	ARNTL(6), CLOCK(4), CRY1(7), CRY2(3), CSNK1E(4), PER1(8)	2828041	32	26	31	15	19	3	1	3	6	0	0.616	1.000	1.000
577	FATTY_ACID_BIOSYNTHESIS_PATH_2		ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS	9	ACAA1(5), ACAA2(1), ACAT2(1), ECHS1(2), EHHADH(6), HADHA(8), HADHB(4), SDS(2)	2803354	29	26	28	14	18	3	1	4	3	0	0.538	1.000	1.000
578	GLOBOSIDE_METABOLISM		A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1	12	A4GALT(5), FUT1(3), FUT2(3), GBGT1(2), GLA(1), HEXA(5), HEXB(4), NAGA(3), ST3GAL1(6), ST3GAL2(1), ST3GAL4(1), ST8SIA1(1)	3156897	35	26	34	24	22	4	0	5	4	0	0.684	1.000	1.000
579	HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES	Genes involved in glycosphingolipid biosynthesis - lactoseries	ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4	10	ABO(6), B3GALT1(11), B3GALT2(1), B3GALT5(1), B3GNT5(1), FUT1(3), FUT2(3), FUT3(4), ST3GAL3(1), ST3GAL4(1)	2400983	32	26	32	25	23	3	0	3	3	0	0.824	1.000	1.000
580	IONPATHWAY	Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm.	P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B	4	P2RY2(8), PLCG1(9), PRKCA(10), PTK2B(10)	2265197	37	26	36	26	28	3	1	2	3	0	0.564	1.000	1.000
581	NUCLEOTIDE_METABOLISM		ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM	14	ADSL(6), ADSS(2), IMPDH1(2), MTHFD2(2), POLD1(6), POLG(8), PRPS2(3), RRM1(3)	4159305	32	26	32	25	17	3	1	5	6	0	0.957	1.000	1.000
582	PROTEASOMEPATHWAY	Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process.	PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A	20	PSMA1(5), PSMA2(1), PSMA4(1), PSMA5(3), PSMA6(4), PSMB1(1), PSMB2(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMB7(1), PSMC3(4), PSMD14(1), RPN2(2), UBE3A(6)	4355454	34	26	34	17	18	4	1	8	3	0	0.715	1.000	1.000
583	SODDPATHWAY	Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs.	BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2	10	BAG4(3), BIRC3(7), CASP8(8), RIPK1(1), TNF(1), TNFRSF1A(3), TNFRSF1B(3), TRAF2(2)	2744700	28	26	28	12	19	1	2	3	3	0	0.340	1.000	1.000
584	ARENRF2PATHWAY	Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control.	CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1	13	FOS(2), JUN(1), KEAP1(2), MAFG(1), MAPK1(4), MAPK14(5), MAPK8(1), NFE2L2(4), PRKCA(10)	2962889	30	25	29	14	19	2	0	4	5	0	0.469	1.000	1.000
585	HSA00460_CYANOAMINO_ACID_METABOLISM	Genes involved in cyanoamino acid metabolism	ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2	6	ASRGL1(3), GBA(3), GBA3(14), GGT1(6), SHMT1(1), SHMT2(2)	1794474	29	25	27	16	22	1	0	3	3	0	0.332	1.000	1.000
586	RANPATHWAY	RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import.	CHC1, RAN, RANBP1, RANBP2, RANGAP1	4	RAN(1), RANBP2(22), RANGAP1(3)	2856977	26	24	26	11	17	2	1	3	3	0	0.651	1.000	1.000
587	KERATAN_SULFATE_BIOSYNTHESIS		B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4	10	B3GNT1(2), B4GALT1(2), B4GALT2(2), B4GALT3(2), B4GALT5(2), FUT8(8), ST3GAL1(6), ST3GAL2(1), ST3GAL3(1), ST3GAL4(1)	2630152	27	23	27	17	14	6	3	2	2	0	0.722	1.000	1.000
588	PTC1PATHWAY	The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition.	CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1	9	CCNH(2), CDC25A(8), CDC25B(4), CDC25C(4), MNAT1(2), SHH(4), XPO1(2)	2926615	26	23	26	11	15	3	2	5	1	0	0.522	1.000	1.000
589	AHSPPATHWAY	Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits.	ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS	11	ALAD(5), ALAS1(1), ALAS2(5), CPO(2), FECH(3), GATA1(2), HBB(6), HMBS(1), UROS(1)	2557315	26	22	25	18	20	2	0	1	3	0	0.701	1.000	1.000
590	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES		ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3	7	ABO(6), FUT1(3), FUT2(3), FUT3(4), FUT5(6), FUT6(4), ST3GAL3(1)	1671750	27	22	27	18	15	3	1	2	6	0	0.478	1.000	1.000
591	CYANOAMINO_ACID_METABOLISM		ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2	5	GBA3(14), GGT1(6), SHMT1(1), SHMT2(2)	1359033	23	22	21	15	17	1	0	3	2	0	0.473	1.000	1.000
592	HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES	Genes involved in synthesis and degradation of ketone bodies	ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2	9	ACAT2(1), BDH1(5), HMGCL(4), HMGCS1(2), HMGCS2(17), OXCT1(4), OXCT2(3)	2393850	36	22	35	20	24	5	0	5	2	0	0.677	1.000	1.000
593	ST_G_ALPHA_S_PATHWAY	The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation.	ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP	11	CAMP(1), CREB3(1), CREB5(9), MAPK1(4), RAF1(8), SNX13(1), SRC(1), TERF2IP(1)	3245548	26	22	26	27	15	3	1	4	3	0	0.997	1.000	1.000
594	HBXPATHWAY	Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm.	CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC	8	GRB2(2), HBXIP(1), HRAS(3), PTK2B(10), SHC1(1), SOS1(8), SRC(1)	2947939	26	21	26	22	18	2	0	4	2	0	0.983	1.000	1.000
595	RNAPATHWAY	dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation.	CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53	8	CHUK(2), DNAJC3(2), EIF2S1(1), MAP3K14(3), NFKB1(7), NFKBIA(2), RELA(4)	2969544	21	21	21	12	11	4	1	4	1	0	0.761	1.000	1.000
596	HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE	Genes involved in reductive carboxylate cycle (CO2 fixation)	ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2	10	ACLY(9), ACO1(5), ACO2(4), ACSS1(1), ACSS2(4), FH(3), IDH2(2), MDH1(1), MDH2(4)	4195866	33	20	31	22	21	0	2	6	4	0	0.725	1.000	1.000
597	KREBPATHWAY	The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain.	ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2	8	ACO2(4), CS(2), FH(3), IDH2(2), MDH1(1), OGDH(11), SDHA(1)	3176777	24	20	23	17	15	0	2	3	4	0	0.860	1.000	1.000
598	LDLPATHWAY	Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation.	ACAT1, CCL2, CSF1, IL6, LDLR, LPL	6	CCL2(1), CSF1(10), IL6(2), LDLR(14), LPL(3)	1796343	30	20	30	15	21	3	2	3	1	0	0.321	1.000	1.000
599	MSPPATHWAY	Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development.	CCL2, CSF1, IL1B, MST1, MST1R, TNF	6	CCL2(1), CSF1(10), IL1B(6), MST1(1), MST1R(7), TNF(1)	2192503	26	20	25	21	20	2	1	0	3	0	0.845	1.000	1.000
600	BBCELLPATHWAY	Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells.	CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6	4	CD28(1), CD4(6), HLA-DRA(11), HLA-DRB1(3)	788509	21	19	21	14	16	1	0	3	1	0	0.536	1.000	1.000
601	HSA00625_TETRACHLOROETHENE_DEGRADATION	Genes involved in tetrachloroethene degradation	AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14	7	AKR1B10(8), EPHX2(4), HSD3B7(3), RDH11(2), RDH12(2), RDH13(3)	1616002	22	19	22	17	15	1	2	1	3	0	0.763	1.000	1.000
602	HSA00750_VITAMIN_B6_METABOLISM	Genes involved in vitamin B6 metabolism	AOX1, PDXK, PDXP, PNPO, PSAT1	5	AOX1(21), PNPO(1), PSAT1(2)	1631742	24	19	23	18	20	1	1	2	0	0	0.856	1.000	1.000
603	HSA00791_ATRAZINE_DEGRADATION	Genes involved in atrazine degradation	ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4	9	ADAR(5), APOBEC1(3), APOBEC2(3), APOBEC3A(2), APOBEC3B(2), APOBEC3C(2), APOBEC3F(4), APOBEC3G(2)	2478826	23	19	23	26	17	2	3	1	0	0	0.993	1.000	1.000
604	IFNGPATHWAY	IFN gamma signaling pathway	IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1	6	IFNG(2), IFNGR1(4), IFNGR2(4), JAK1(6), JAK2(9), STAT1(4)	2736082	29	19	27	10	11	1	1	7	9	0	0.687	1.000	1.000
605	GANGLIOSIDE_BIOSYNTHESIS		B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1	8	B3GALT4(2), ST3GAL1(6), ST3GAL2(1), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(2), ST6GALNAC4(1), ST8SIA1(1)	1902275	16	16	16	11	11	2	1	2	0	0	0.650	1.000	1.000
606	TCAPOPTOSISPATHWAY	HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis.	CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@	6	CCR5(7), CD28(1), CD3D(5), CD3E(2), CD3G(1), CD4(6)	1074220	22	16	22	22	15	3	0	3	1	0	0.918	1.000	1.000
607	HSA00130_UBIQUINONE_BIOSYNTHESIS	Genes involved in ubiquinone biosynthesis	COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11	8	COQ2(1), COQ3(2), COQ5(2), COQ6(1), COQ7(2), NDUFA12(1), NDUFA13(6)	1333886	15	15	14	11	12	1	2	0	0	0	0.873	1.000	1.000
608	REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION		ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2	8	ACO1(5), ACO2(4), FH(3), IDH2(2), MDH1(1), MDH2(4), SDHB(1)	2721683	20	15	18	13	13	0	2	2	3	0	0.709	1.000	1.000
609	SA_BONE_MORPHOGENETIC	Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera.	BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6	4	BMP1(5), BMPR1A(2), BMPR1B(3), BMPR2(5)	2106226	15	15	15	10	7	3	0	3	2	0	0.837	1.000	1.000
610	BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES		ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1	6	ABO(6), B3GNT1(2), FUT1(3), FUT2(3), ST8SIA1(1)	1777543	15	14	15	12	11	1	1	1	1	0	0.770	1.000	1.000
611	HSA00643_STYRENE_DEGRADATION	Genes involved in styrene degradation	FAH, GSTZ1, HGD	3	FAH(4), HGD(12)	754252	16	14	16	16	12	2	2	0	0	0	0.938	1.000	1.000
612	NOTCHPATHWAY	Proteolysis and Signaling Pathway of Notch	ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH	5	ADAM17(1), DLL1(2), FURIN(5), NOTCH1(6), PSEN1(1)	3078315	15	14	15	17	8	3	1	3	0	0	0.972	1.000	1.000
613	HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS	Genes involved in peptidoglycan biosynthesis	GLUL, PGLYRP2	2	GLUL(2), PGLYRP2(17)	612499	19	12	18	11	14	2	1	2	0	0	0.580	1.000	1.000
614	ARGININECPATHWAY	Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle.	ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH	6	ALDH4A1(6), ARG1(1), GLS(2), GLUD1(2), OAT(3), PRODH(1)	1823373	15	11	15	13	5	5	2	2	1	0	0.950	1.000	1.000
615	HSA00520_NUCLEOTIDE_SUGARS_METABOLISM	Genes involved in nucleotide sugars metabolism	GALE, GALT, TGDS, UGDH, UGP2, UXS1	6	GALT(2), TGDS(1), UGDH(1), UGP2(1), UXS1(4)	1652848	9	9	9	10	4	0	1	0	4	0	0.987	1.000	1.000
616	HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM	Genes involved in C5-branched dibasic acid metabolism	ILVBL, SUCLA2	2	ILVBL(4)	712936	4	4	4	5	3	0	0	1	0	0	0.943	1.000	1.000
