This pipeline computes the correlation between significant copy number variation (cnv focal) genes and selected clinical features.
Testing the association between copy number variation 98 focal events and 5 clinical features across 470 patients, 164 significant findings detected with Q value < 0.25.
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AMP PEAK 1(1P35.2) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 2(1P34.2) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 4(1Q21.3) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 5(1Q22) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 7(2P24.3) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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AMP PEAK 8(2Q13) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 9(3P25.1) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 10(3P14.1) MUTATION ANALYSIS cnv correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 11(3Q26.2) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 12(3Q26.2) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 13(4P16.3) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 14(5P15.33) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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AMP PEAK 15(5Q35.3) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 16(6P24.2) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 17(6Q25.1) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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AMP PEAK 18(7Q22.1) MUTATION ANALYSIS cnv correlated to 'Time to Death'.
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AMP PEAK 19(8P11.21) MUTATION ANALYSIS cnv correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 20(8Q24.21) MUTATION ANALYSIS cnv correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 21(8Q24.21) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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AMP PEAK 22(9P24.2) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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AMP PEAK 23(9Q34.3) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 25(11P11.2) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 26(11Q13.2) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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AMP PEAK 27(11Q14.1) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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AMP PEAK 28(12P12.1) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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AMP PEAK 29(12Q13.11) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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AMP PEAK 30(12Q13.2) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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AMP PEAK 31(13Q34) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 32(14Q24.3) MUTATION ANALYSIS cnv correlated to 'Time to Death', 'AGE', and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 33(15Q26.3) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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AMP PEAK 34(16P11.2) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 35(17Q11.2) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 36(17Q12) MUTATION ANALYSIS cnv correlated to 'Time to Death', 'AGE', and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 37(17Q25.1) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 38(18P11.31) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 39(18Q11.2) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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AMP PEAK 40(19P13.2) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 41(19P13.11) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 42(19Q12) MUTATION ANALYSIS cnv correlated to 'Time to Death', 'AGE', and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 43(20P13) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 44(20Q11.21) MUTATION ANALYSIS cnv correlated to 'Time to Death', 'AGE', and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 45(20Q13.12) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 46(20Q13.33) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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AMP PEAK 47(22Q12.2) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE' and 'COMPLETENESS.OF.RESECTION'.
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DEL PEAK 1(1P36.11) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 3(2Q22.1) MUTATION ANALYSIS cnv correlated to 'Time to Death' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 4(2Q37.3) MUTATION ANALYSIS cnv correlated to 'AGE'.
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DEL PEAK 5(3P14.2) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 6(3Q13.31) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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DEL PEAK 7(4P16.3) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 8(4P15.31) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 9(4Q22.1) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 10(4Q34.3) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 11(5Q11.2) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 12(6Q26) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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DEL PEAK 13(7P22.3) MUTATION ANALYSIS cnv correlated to 'Time to Death', 'AGE', and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 14(7Q11.22) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 15(7Q31.1) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 16(7Q36.1) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 17(8P23.2) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 18(8P21.2) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 19(9P23) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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DEL PEAK 20(9Q21.2) MUTATION ANALYSIS cnv correlated to 'Time to Death', 'AGE', and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 21(9Q34.11) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 22(10Q23.31) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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DEL PEAK 23(11P15.5) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 24(11Q14.1) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 25(11Q25) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 26(12Q23.1) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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DEL PEAK 27(12Q24.33) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 28(13Q11) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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DEL PEAK 29(13Q14.2) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 30(14Q13.1) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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DEL PEAK 31(15Q15.1) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 32(15Q23) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 33(16P13.3) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 34(16Q21) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 35(16Q23.1) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 36(17P13.3) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 37(17P11.2) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 38(17P11.2) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 39(17Q11.2) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 40(17Q21.2) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 41(18Q23) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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DEL PEAK 42(19P13.3) MUTATION ANALYSIS cnv correlated to 'Time to Death', 'AGE', and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 43(19P12) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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DEL PEAK 44(19Q13.43) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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DEL PEAK 46(22Q12.1) MUTATION ANALYSIS cnv correlated to 'HISTOLOGICAL.TYPE'.
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DEL PEAK 47(22Q13.31) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 48(22Q13.32) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
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DEL PEAK 49(XP21.1) MUTATION ANALYSIS cnv correlated to 'AGE' and 'HISTOLOGICAL.TYPE'.
Table 1. Get Full Table Overview of the association between significant copy number variation of 98 focal events and 5 clinical features. Shown in the table are P values (Q values). Thresholded by Q value < 0.25, 164 significant findings detected.
|
Clinical Features |
Time to Death |
AGE |
HISTOLOGICAL TYPE |
RADIATIONS RADIATION REGIMENINDICATION |
COMPLETENESS OF RESECTION |
||
| nCNV (%) | nWild-Type | logrank test | t-test | Fisher's exact test | Fisher's exact test | Fisher's exact test | |
| AMP PEAK 32(14Q24 3) MUTATION ANALYSIS | 54 (11%) | 416 |
0.000704 (0.231) |
0.000179 (0.0629) |
8.71e-13 (3.79e-10) |
0.0811 (1.00) |
0.74 (1.00) |
| AMP PEAK 36(17Q12) MUTATION ANALYSIS | 62 (13%) | 408 |
0.000339 (0.116) |
4.66e-05 (0.017) |
1.19e-19 (5.5e-17) |
1 (1.00) |
0.115 (1.00) |
| AMP PEAK 42(19Q12) MUTATION ANALYSIS | 94 (20%) | 376 |
0.000294 (0.101) |
2.62e-09 (1.08e-06) |
2.16e-38 (1.05e-35) |
0.372 (1.00) |
0.225 (1.00) |
| AMP PEAK 44(20Q11 21) MUTATION ANALYSIS | 118 (25%) | 352 |
0.000368 (0.126) |
6.22e-08 (2.47e-05) |
5.04e-25 (2.41e-22) |
0.0453 (1.00) |
0.0386 (1.00) |
| DEL PEAK 13(7P22 3) MUTATION ANALYSIS | 64 (14%) | 406 |
0.000434 (0.147) |
6.1e-05 (0.022) |
1.18e-14 (5.16e-12) |
0.373 (1.00) |
0.172 (1.00) |
| DEL PEAK 20(9Q21 2) MUTATION ANALYSIS | 104 (22%) | 366 |
0.000763 (0.25) |
3.62e-11 (1.53e-08) |
3.28e-20 (1.53e-17) |
0.269 (1.00) |
0.188 (1.00) |
| DEL PEAK 42(19P13 3) MUTATION ANALYSIS | 131 (28%) | 339 |
3.7e-05 (0.0135) |
7.8e-12 (3.35e-09) |
1.91e-54 (9.35e-52) |
0.141 (1.00) |
0.00351 (0.999) |
| AMP PEAK 1(1P35 2) MUTATION ANALYSIS | 47 (10%) | 423 |
0.125 (1.00) |
0.000674 (0.223) |
1.46e-11 (6.24e-09) |
1 (1.00) |
0.927 (1.00) |
| AMP PEAK 2(1P34 2) MUTATION ANALYSIS | 59 (13%) | 411 |
0.0564 (1.00) |
0.000435 (0.147) |
1.38e-16 (6.17e-14) |
0.282 (1.00) |
0.0608 (1.00) |
| AMP PEAK 4(1Q21 3) MUTATION ANALYSIS | 209 (44%) | 261 |
0.0605 (1.00) |
2.17e-05 (0.00801) |
0.000464 (0.157) |
0.414 (1.00) |
0.581 (1.00) |
| AMP PEAK 5(1Q22) MUTATION ANALYSIS | 222 (47%) | 248 |
0.00901 (1.00) |
6.12e-07 (0.000238) |
1.22e-06 (0.000469) |
0.359 (1.00) |
0.286 (1.00) |
| AMP PEAK 8(2Q13) MUTATION ANALYSIS | 100 (21%) | 370 |
0.00227 (0.68) |
0.000279 (0.0968) |
4.96e-18 (2.26e-15) |
0.535 (1.00) |
0.157 (1.00) |
| AMP PEAK 9(3P25 1) MUTATION ANALYSIS | 66 (14%) | 404 |
0.0474 (1.00) |
0.00018 (0.0631) |
1.77e-10 (7.4e-08) |
0.106 (1.00) |
0.6 (1.00) |
| AMP PEAK 10(3P14 1) MUTATION ANALYSIS | 50 (11%) | 420 |
0.000607 (0.201) |
0.0117 (1.00) |
0.000285 (0.0983) |
0.046 (1.00) |
0.383 (1.00) |
| AMP PEAK 11(3Q26 2) MUTATION ANALYSIS | 143 (30%) | 327 |
0.0058 (1.00) |
1.18e-10 (4.93e-08) |
7.81e-27 (3.78e-24) |
0.0772 (1.00) |
0.141 (1.00) |
| AMP PEAK 12(3Q26 2) MUTATION ANALYSIS | 135 (29%) | 335 |
0.00631 (1.00) |
2.05e-08 (8.27e-06) |
1.48e-26 (7.13e-24) |
0.0911 (1.00) |
0.0969 (1.00) |
| AMP PEAK 13(4P16 3) MUTATION ANALYSIS | 43 (9%) | 427 |
0.32 (1.00) |
1.79e-05 (0.00665) |
2.76e-12 (1.19e-09) |
0.597 (1.00) |
0.424 (1.00) |
| AMP PEAK 15(5Q35 3) MUTATION ANALYSIS | 44 (9%) | 426 |
0.315 (1.00) |
0.000282 (0.0975) |
2.19e-09 (9.07e-07) |
0.225 (1.00) |
0.305 (1.00) |
| AMP PEAK 16(6P24 2) MUTATION ANALYSIS | 92 (20%) | 378 |
0.233 (1.00) |
1.92e-06 (0.000732) |
1.17e-19 (5.41e-17) |
0.199 (1.00) |
0.617 (1.00) |
| AMP PEAK 19(8P11 21) MUTATION ANALYSIS | 140 (30%) | 330 |
0.000523 (0.175) |
0.3 (1.00) |
1.45e-07 (5.68e-05) |
0.0257 (1.00) |
0.00289 (0.846) |
| AMP PEAK 20(8Q24 21) MUTATION ANALYSIS | 177 (38%) | 293 |
0.00056 (0.187) |
0.457 (1.00) |
5.59e-14 (2.45e-11) |
0.0154 (1.00) |
0.0468 (1.00) |
| AMP PEAK 23(9Q34 3) MUTATION ANALYSIS | 33 (7%) | 437 |
0.0067 (1.00) |
0.000194 (0.0676) |
6.89e-07 (0.000268) |
0.843 (1.00) |
0.35 (1.00) |
| AMP PEAK 25(11P11 2) MUTATION ANALYSIS | 42 (9%) | 428 |
0.00405 (1.00) |
5.04e-05 (0.0182) |
6.02e-10 (2.51e-07) |
0.858 (1.00) |
0.41 (1.00) |
| AMP PEAK 31(13Q34) MUTATION ANALYSIS | 48 (10%) | 422 |
0.882 (1.00) |
1.47e-06 (0.000566) |
1.98e-13 (8.65e-11) |
0.867 (1.00) |
0.0706 (1.00) |
| AMP PEAK 34(16P11 2) MUTATION ANALYSIS | 53 (11%) | 417 |
0.00381 (1.00) |
5e-05 (0.0181) |
6.29e-14 (2.75e-11) |
0.75 (1.00) |
0.115 (1.00) |
| AMP PEAK 35(17Q11 2) MUTATION ANALYSIS | 60 (13%) | 410 |
0.00615 (1.00) |
0.000516 (0.173) |
4.96e-20 (2.3e-17) |
0.544 (1.00) |
0.00096 (0.306) |
| AMP PEAK 37(17Q25 1) MUTATION ANALYSIS | 84 (18%) | 386 |
0.00579 (1.00) |
7.77e-05 (0.0278) |
6.71e-17 (3.03e-14) |
0.598 (1.00) |
0.154 (1.00) |
| AMP PEAK 38(18P11 31) MUTATION ANALYSIS | 75 (16%) | 395 |
0.0723 (1.00) |
0.000173 (0.0607) |
1.47e-21 (6.94e-19) |
0.0372 (1.00) |
0.00499 (1.00) |
| AMP PEAK 40(19P13 2) MUTATION ANALYSIS | 76 (16%) | 394 |
0.145 (1.00) |
3.11e-11 (1.32e-08) |
3.37e-20 (1.57e-17) |
0.213 (1.00) |
0.528 (1.00) |
| AMP PEAK 41(19P13 11) MUTATION ANALYSIS | 78 (17%) | 392 |
0.0643 (1.00) |
1.01e-10 (4.27e-08) |
3.08e-23 (1.47e-20) |
0.0543 (1.00) |
0.183 (1.00) |
| AMP PEAK 43(20P13) MUTATION ANALYSIS | 96 (20%) | 374 |
0.188 (1.00) |
2.23e-05 (0.00824) |
1.19e-12 (5.15e-10) |
0.167 (1.00) |
0.136 (1.00) |
| AMP PEAK 45(20Q13 12) MUTATION ANALYSIS | 125 (27%) | 345 |
0.00773 (1.00) |
1.54e-08 (6.25e-06) |
2.09e-23 (1e-20) |
0.00568 (1.00) |
0.0238 (1.00) |
| AMP PEAK 46(20Q13 33) MUTATION ANALYSIS | 121 (26%) | 349 |
0.0243 (1.00) |
7.89e-08 (3.13e-05) |
1.09e-18 (5.03e-16) |
0.00341 (0.979) |
0.0152 (1.00) |
| AMP PEAK 47(22Q12 2) MUTATION ANALYSIS | 52 (11%) | 418 |
0.0071 (1.00) |
0.00148 (0.459) |
1.42e-20 (6.66e-18) |
0.143 (1.00) |
0.000681 (0.224) |
| DEL PEAK 1(1P36 11) MUTATION ANALYSIS | 68 (14%) | 402 |
0.022 (1.00) |
1.6e-05 (0.00599) |
1.58e-15 (7.04e-13) |
0.562 (1.00) |
0.0347 (1.00) |
| DEL PEAK 3(2Q22 1) MUTATION ANALYSIS | 42 (9%) | 428 |
1.16e-10 (4.88e-08) |
0.00526 (1.00) |
8.59e-09 (3.5e-06) |
0.00365 (1.00) |
0.00891 (1.00) |
| DEL PEAK 5(3P14 2) MUTATION ANALYSIS | 65 (14%) | 405 |
0.26 (1.00) |
0.000129 (0.046) |
3.02e-16 (1.35e-13) |
0.186 (1.00) |
0.593 (1.00) |
| DEL PEAK 7(4P16 3) MUTATION ANALYSIS | 75 (16%) | 395 |
0.00335 (0.967) |
8.5e-05 (0.0304) |
4.35e-17 (1.97e-14) |
0.265 (1.00) |
0.744 (1.00) |
| DEL PEAK 8(4P15 31) MUTATION ANALYSIS | 77 (16%) | 393 |
0.00411 (1.00) |
3.51e-05 (0.0129) |
6.46e-17 (2.92e-14) |
0.0542 (1.00) |
0.236 (1.00) |
| DEL PEAK 9(4Q22 1) MUTATION ANALYSIS | 85 (18%) | 385 |
0.00575 (1.00) |
4.86e-06 (0.00185) |
1.68e-26 (8.08e-24) |
0.185 (1.00) |
0.0306 (1.00) |
| DEL PEAK 10(4Q34 3) MUTATION ANALYSIS | 105 (22%) | 365 |
0.0149 (1.00) |
6e-06 (0.00226) |
1.95e-27 (9.47e-25) |
0.223 (1.00) |
0.0514 (1.00) |
| DEL PEAK 11(5Q11 2) MUTATION ANALYSIS | 90 (19%) | 380 |
0.0149 (1.00) |
6.22e-05 (0.0224) |
2.4e-25 (1.15e-22) |
0.365 (1.00) |
0.564 (1.00) |
| DEL PEAK 14(7Q11 22) MUTATION ANALYSIS | 37 (8%) | 433 |
0.88 (1.00) |
2.65e-05 (0.00973) |
2.72e-08 (1.09e-05) |
0.449 (1.00) |
0.679 (1.00) |
| DEL PEAK 15(7Q31 1) MUTATION ANALYSIS | 46 (10%) | 424 |
0.0815 (1.00) |
7.14e-07 (0.000276) |
2.99e-18 (1.36e-15) |
1 (1.00) |
0.235 (1.00) |
| DEL PEAK 16(7Q36 1) MUTATION ANALYSIS | 56 (12%) | 414 |
0.0182 (1.00) |
1.22e-09 (5.09e-07) |
3.46e-21 (1.63e-18) |
0.755 (1.00) |
0.131 (1.00) |
| DEL PEAK 17(8P23 2) MUTATION ANALYSIS | 96 (20%) | 374 |
0.00547 (1.00) |
0.000249 (0.0868) |
5.28e-30 (2.57e-27) |
0.259 (1.00) |
0.0147 (1.00) |
| DEL PEAK 18(8P21 2) MUTATION ANALYSIS | 94 (20%) | 376 |
0.0207 (1.00) |
7.73e-06 (0.0029) |
1.67e-37 (8.14e-35) |
0.372 (1.00) |
0.0565 (1.00) |
| DEL PEAK 21(9Q34 11) MUTATION ANALYSIS | 109 (23%) | 361 |
0.00548 (1.00) |
3.8e-08 (1.52e-05) |
1.39e-18 (6.36e-16) |
0.335 (1.00) |
0.286 (1.00) |
| DEL PEAK 23(11P15 5) MUTATION ANALYSIS | 83 (18%) | 387 |
0.0144 (1.00) |
1.52e-06 (0.000581) |
1.14e-18 (5.24e-16) |
0.0443 (1.00) |
0.0648 (1.00) |
| DEL PEAK 24(11Q14 1) MUTATION ANALYSIS | 57 (12%) | 413 |
0.0654 (1.00) |
1.76e-05 (0.00658) |
2.63e-15 (1.16e-12) |
0.35 (1.00) |
0.647 (1.00) |
| DEL PEAK 25(11Q25) MUTATION ANALYSIS | 78 (17%) | 392 |
0.00135 (0.424) |
0.000599 (0.199) |
1.31e-16 (5.89e-14) |
0.00924 (1.00) |
0.329 (1.00) |
| DEL PEAK 27(12Q24 33) MUTATION ANALYSIS | 52 (11%) | 418 |
0.121 (1.00) |
6.99e-05 (0.0251) |
3.41e-15 (1.51e-12) |
0.0726 (1.00) |
0.00968 (1.00) |
| DEL PEAK 29(13Q14 2) MUTATION ANALYSIS | 83 (18%) | 387 |
0.00224 (0.672) |
0.000395 (0.135) |
2.98e-07 (0.000116) |
0.0443 (1.00) |
0.333 (1.00) |
| DEL PEAK 31(15Q15 1) MUTATION ANALYSIS | 115 (24%) | 355 |
0.00116 (0.366) |
5.86e-08 (2.33e-05) |
3.86e-23 (1.83e-20) |
0.0332 (1.00) |
0.0333 (1.00) |
| DEL PEAK 32(15Q23) MUTATION ANALYSIS | 96 (20%) | 374 |
0.0376 (1.00) |
2e-05 (0.00743) |
4.74e-23 (2.25e-20) |
0.102 (1.00) |
0.307 (1.00) |
| DEL PEAK 33(16P13 3) MUTATION ANALYSIS | 73 (16%) | 397 |
0.0146 (1.00) |
1.81e-07 (7.11e-05) |
4.39e-20 (2.04e-17) |
0.325 (1.00) |
0.0616 (1.00) |
| DEL PEAK 34(16Q21) MUTATION ANALYSIS | 129 (27%) | 341 |
0.0382 (1.00) |
8.28e-09 (3.4e-06) |
3.09e-23 (1.47e-20) |
0.173 (1.00) |
0.101 (1.00) |
| DEL PEAK 35(16Q23 1) MUTATION ANALYSIS | 139 (30%) | 331 |
0.0047 (1.00) |
2.1e-07 (8.21e-05) |
1.28e-26 (6.18e-24) |
0.315 (1.00) |
0.00362 (1.00) |
| DEL PEAK 36(17P13 3) MUTATION ANALYSIS | 100 (21%) | 370 |
0.00201 (0.61) |
0.000146 (0.0519) |
1.62e-20 (7.58e-18) |
0.172 (1.00) |
0.248 (1.00) |
| DEL PEAK 37(17P11 2) MUTATION ANALYSIS | 107 (23%) | 363 |
0.00134 (0.422) |
8.51e-07 (0.000328) |
4.43e-27 (2.15e-24) |
0.182 (1.00) |
0.554 (1.00) |
| DEL PEAK 38(17P11 2) MUTATION ANALYSIS | 100 (21%) | 370 |
0.000894 (0.289) |
5.01e-06 (0.0019) |
1.04e-19 (4.81e-17) |
0.264 (1.00) |
0.712 (1.00) |
| DEL PEAK 39(17Q11 2) MUTATION ANALYSIS | 86 (18%) | 384 |
0.0438 (1.00) |
7.05e-06 (0.00265) |
2.11e-11 (9.01e-09) |
0.148 (1.00) |
0.173 (1.00) |
| DEL PEAK 40(17Q21 2) MUTATION ANALYSIS | 91 (19%) | 379 |
0.0036 (1.00) |
2.47e-05 (0.00909) |
6.67e-15 (2.93e-12) |
0.123 (1.00) |
0.124 (1.00) |
| DEL PEAK 47(22Q13 31) MUTATION ANALYSIS | 112 (24%) | 358 |
0.000949 (0.304) |
8.3e-09 (3.4e-06) |
4.94e-22 (2.33e-19) |
0.0945 (1.00) |
0.732 (1.00) |
| DEL PEAK 48(22Q13 32) MUTATION ANALYSIS | 117 (25%) | 353 |
0.000906 (0.291) |
1.05e-07 (4.14e-05) |
3.46e-22 (1.64e-19) |
0.0251 (1.00) |
0.354 (1.00) |
| DEL PEAK 49(XP21 1) MUTATION ANALYSIS | 74 (16%) | 396 |
0.000789 (0.257) |
0.000163 (0.0576) |
1.99e-15 (8.82e-13) |
0.162 (1.00) |
0.119 (1.00) |
| AMP PEAK 7(2P24 3) MUTATION ANALYSIS | 104 (22%) | 366 |
0.00339 (0.975) |
0.0182 (1.00) |
1.88e-11 (8.03e-09) |
0.0192 (1.00) |
0.726 (1.00) |
| AMP PEAK 14(5P15 33) MUTATION ANALYSIS | 73 (16%) | 397 |
0.00388 (1.00) |
0.0021 (0.633) |
1.92e-18 (8.75e-16) |
0.325 (1.00) |
0.0652 (1.00) |
| AMP PEAK 17(6Q25 1) MUTATION ANALYSIS | 70 (15%) | 400 |
0.278 (1.00) |
0.0263 (1.00) |
5.31e-06 (0.00201) |
0.668 (1.00) |
0.283 (1.00) |
| AMP PEAK 18(7Q22 1) MUTATION ANALYSIS | 76 (16%) | 394 |
0.000598 (0.199) |
0.0414 (1.00) |
0.00308 (0.899) |
0.128 (1.00) |
0.498 (1.00) |
| AMP PEAK 21(8Q24 21) MUTATION ANALYSIS | 186 (40%) | 284 |
0.0013 (0.41) |
0.176 (1.00) |
1.84e-15 (8.18e-13) |
0.00659 (1.00) |
0.00156 (0.481) |
| AMP PEAK 22(9P24 2) MUTATION ANALYSIS | 53 (11%) | 417 |
0.00203 (0.615) |
0.00435 (1.00) |
3.25e-09 (1.34e-06) |
0.199 (1.00) |
0.454 (1.00) |
| AMP PEAK 26(11Q13 2) MUTATION ANALYSIS | 62 (13%) | 408 |
0.00595 (1.00) |
0.00262 (0.772) |
2.31e-08 (9.29e-06) |
1 (1.00) |
0.114 (1.00) |
| AMP PEAK 27(11Q14 1) MUTATION ANALYSIS | 46 (10%) | 424 |
0.00104 (0.329) |
0.0103 (1.00) |
2.34e-09 (9.68e-07) |
0.307 (1.00) |
0.376 (1.00) |
| AMP PEAK 28(12P12 1) MUTATION ANALYSIS | 73 (16%) | 397 |
0.568 (1.00) |
0.194 (1.00) |
8.31e-09 (3.4e-06) |
0.673 (1.00) |
0.293 (1.00) |
| AMP PEAK 29(12Q13 11) MUTATION ANALYSIS | 73 (16%) | 397 |
0.802 (1.00) |
0.696 (1.00) |
4.93e-09 (2.03e-06) |
0.205 (1.00) |
0.248 (1.00) |
| AMP PEAK 30(12Q13 2) MUTATION ANALYSIS | 81 (17%) | 389 |
0.99 (1.00) |
0.0992 (1.00) |
5.02e-08 (2e-05) |
0.0585 (1.00) |
0.0692 (1.00) |
| AMP PEAK 33(15Q26 3) MUTATION ANALYSIS | 31 (7%) | 439 |
0.106 (1.00) |
0.0363 (1.00) |
0.000148 (0.0523) |
0.149 (1.00) |
0.0075 (1.00) |
| AMP PEAK 39(18Q11 2) MUTATION ANALYSIS | 59 (13%) | 411 |
0.0247 (1.00) |
0.00179 (0.547) |
1.93e-16 (8.63e-14) |
0.442 (1.00) |
0.0331 (1.00) |
| DEL PEAK 4(2Q37 3) MUTATION ANALYSIS | 46 (10%) | 424 |
0.116 (1.00) |
0.000477 (0.161) |
0.000804 (0.261) |
0.172 (1.00) |
0.0715 (1.00) |
| DEL PEAK 6(3Q13 31) MUTATION ANALYSIS | 25 (5%) | 445 |
0.988 (1.00) |
0.00775 (1.00) |
1.67e-06 (0.000639) |
0.373 (1.00) |
0.812 (1.00) |
| DEL PEAK 12(6Q26) MUTATION ANALYSIS | 41 (9%) | 429 |
0.361 (1.00) |
0.00247 (0.732) |
3.5e-11 (1.48e-08) |
0.858 (1.00) |
0.971 (1.00) |
| DEL PEAK 19(9P23) MUTATION ANALYSIS | 58 (12%) | 412 |
0.464 (1.00) |
0.0024 (0.714) |
1.21e-11 (5.19e-09) |
0.165 (1.00) |
0.158 (1.00) |
| DEL PEAK 22(10Q23 31) MUTATION ANALYSIS | 62 (13%) | 408 |
0.0355 (1.00) |
0.00313 (0.911) |
1.03e-08 (4.19e-06) |
0.023 (1.00) |
0.129 (1.00) |
| DEL PEAK 26(12Q23 1) MUTATION ANALYSIS | 40 (9%) | 430 |
0.00423 (1.00) |
0.00352 (0.999) |
1.51e-12 (6.52e-10) |
0.273 (1.00) |
0.0192 (1.00) |
| DEL PEAK 28(13Q11) MUTATION ANALYSIS | 78 (17%) | 392 |
0.00219 (0.659) |
0.0014 (0.437) |
9.14e-13 (3.96e-10) |
0.0995 (1.00) |
0.14 (1.00) |
| DEL PEAK 30(14Q13 1) MUTATION ANALYSIS | 59 (13%) | 411 |
0.00246 (0.732) |
0.00467 (1.00) |
8.22e-11 (3.47e-08) |
0.645 (1.00) |
0.927 (1.00) |
| DEL PEAK 41(18Q23) MUTATION ANALYSIS | 81 (17%) | 389 |
0.0038 (1.00) |
0.00267 (0.785) |
1.02e-16 (4.6e-14) |
0.00186 (0.566) |
0.0077 (1.00) |
| DEL PEAK 43(19P12) MUTATION ANALYSIS | 43 (9%) | 427 |
0.00734 (1.00) |
0.0494 (1.00) |
1.99e-08 (8.05e-06) |
0.157 (1.00) |
0.268 (1.00) |
| DEL PEAK 44(19Q13 43) MUTATION ANALYSIS | 54 (11%) | 416 |
0.00313 (0.911) |
0.0014 (0.436) |
3.29e-17 (1.5e-14) |
0.75 (1.00) |
0.051 (1.00) |
| DEL PEAK 46(22Q12 1) MUTATION ANALYSIS | 77 (16%) | 393 |
0.192 (1.00) |
0.00105 (0.333) |
1.29e-07 (5.09e-05) |
0.0542 (1.00) |
0.752 (1.00) |
| AMP PEAK 3(1P22 3) MUTATION ANALYSIS | 79 (17%) | 391 |
0.426 (1.00) |
0.00178 (0.547) |
0.00923 (1.00) |
0.892 (1.00) |
0.411 (1.00) |
| AMP PEAK 6(1Q42 3) MUTATION ANALYSIS | 196 (42%) | 274 |
0.235 (1.00) |
0.00166 (0.512) |
0.073 (1.00) |
0.536 (1.00) |
0.728 (1.00) |
| AMP PEAK 24(10Q22 2) MUTATION ANALYSIS | 127 (27%) | 343 |
0.283 (1.00) |
0.456 (1.00) |
0.033 (1.00) |
0.646 (1.00) |
0.502 (1.00) |
| AMP PEAK 48(XP11 23) MUTATION ANALYSIS | 78 (17%) | 392 |
0.225 (1.00) |
0.152 (1.00) |
0.00733 (1.00) |
0.0203 (1.00) |
0.437 (1.00) |
| AMP PEAK 49(XQ28) MUTATION ANALYSIS | 78 (17%) | 392 |
0.00415 (1.00) |
0.125 (1.00) |
0.000797 (0.259) |
1 (1.00) |
0.143 (1.00) |
| DEL PEAK 2(2P25 3) MUTATION ANALYSIS | 23 (5%) | 447 |
0.0172 (1.00) |
0.104 (1.00) |
0.00439 (1.00) |
0.101 (1.00) |
0.232 (1.00) |
| DEL PEAK 45(20P12 1) MUTATION ANALYSIS | 29 (6%) | 441 |
0.00344 (0.983) |
0.167 (1.00) |
0.000905 (0.291) |
0.675 (1.00) |
0.0861 (1.00) |
P value = 0.000674 (t-test), Q value = 0.22
Table S1. Gene #1: 'AMP PEAK 1(1P35.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 1(1P35.2) MUTATED | 47 | 68.5 (9.4) |
| AMP PEAK 1(1P35.2) WILD-TYPE | 422 | 63.2 (11.4) |
Figure S1. Get High-res Image Gene #1: 'AMP PEAK 1(1P35.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.46e-11 (Fisher's exact test), Q value = 6.2e-09
Table S2. Gene #1: 'AMP PEAK 1(1P35.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 1(1P35.2) MUTATED | 15 | 4 | 28 |
| AMP PEAK 1(1P35.2) WILD-TYPE | 344 | 14 | 65 |
Figure S2. Get High-res Image Gene #1: 'AMP PEAK 1(1P35.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000435 (t-test), Q value = 0.15
Table S3. Gene #2: 'AMP PEAK 2(1P34.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 2(1P34.2) MUTATED | 59 | 68.4 (10.2) |
| AMP PEAK 2(1P34.2) WILD-TYPE | 410 | 63.1 (11.3) |
Figure S3. Get High-res Image Gene #2: 'AMP PEAK 2(1P34.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.38e-16 (Fisher's exact test), Q value = 6.2e-14
Table S4. Gene #2: 'AMP PEAK 2(1P34.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 2(1P34.2) MUTATED | 17 | 6 | 36 |
| AMP PEAK 2(1P34.2) WILD-TYPE | 342 | 12 | 57 |
Figure S4. Get High-res Image Gene #2: 'AMP PEAK 2(1P34.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 2.17e-05 (t-test), Q value = 0.008
Table S5. Gene #4: 'AMP PEAK 4(1Q21.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 4(1Q21.3) MUTATED | 209 | 66.2 (10.5) |
| AMP PEAK 4(1Q21.3) WILD-TYPE | 260 | 61.8 (11.5) |
Figure S5. Get High-res Image Gene #4: 'AMP PEAK 4(1Q21.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 0.000464 (Fisher's exact test), Q value = 0.16
Table S6. Gene #4: 'AMP PEAK 4(1Q21.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 4(1Q21.3) MUTATED | 143 | 8 | 58 |
| AMP PEAK 4(1Q21.3) WILD-TYPE | 216 | 10 | 35 |
Figure S6. Get High-res Image Gene #4: 'AMP PEAK 4(1Q21.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 6.12e-07 (t-test), Q value = 0.00024
Table S7. Gene #5: 'AMP PEAK 5(1Q22) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 5(1Q22) MUTATED | 222 | 66.5 (10.5) |
| AMP PEAK 5(1Q22) WILD-TYPE | 247 | 61.3 (11.4) |
Figure S7. Get High-res Image Gene #5: 'AMP PEAK 5(1Q22) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.22e-06 (Fisher's exact test), Q value = 0.00047
Table S8. Gene #5: 'AMP PEAK 5(1Q22) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 5(1Q22) MUTATED | 148 | 8 | 66 |
| AMP PEAK 5(1Q22) WILD-TYPE | 211 | 10 | 27 |
Figure S8. Get High-res Image Gene #5: 'AMP PEAK 5(1Q22) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.88e-11 (Fisher's exact test), Q value = 8e-09
Table S9. Gene #7: 'AMP PEAK 7(2P24.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 7(2P24.3) MUTATED | 52 | 6 | 46 |
| AMP PEAK 7(2P24.3) WILD-TYPE | 307 | 12 | 47 |
Figure S9. Get High-res Image Gene #7: 'AMP PEAK 7(2P24.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000279 (t-test), Q value = 0.097
Table S10. Gene #8: 'AMP PEAK 8(2Q13) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 8(2Q13) MUTATED | 99 | 67.1 (9.4) |
| AMP PEAK 8(2Q13) WILD-TYPE | 370 | 62.9 (11.6) |
Figure S10. Get High-res Image Gene #8: 'AMP PEAK 8(2Q13) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 4.96e-18 (Fisher's exact test), Q value = 2.3e-15
Table S11. Gene #8: 'AMP PEAK 8(2Q13) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 8(2Q13) MUTATED | 43 | 4 | 53 |
| AMP PEAK 8(2Q13) WILD-TYPE | 316 | 14 | 40 |
Figure S11. Get High-res Image Gene #8: 'AMP PEAK 8(2Q13) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.00018 (t-test), Q value = 0.063
Table S12. Gene #9: 'AMP PEAK 9(3P25.1) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 9(3P25.1) MUTATED | 66 | 68.7 (10.9) |
| AMP PEAK 9(3P25.1) WILD-TYPE | 403 | 63.0 (11.2) |
Figure S12. Get High-res Image Gene #9: 'AMP PEAK 9(3P25.1) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.77e-10 (Fisher's exact test), Q value = 7.4e-08
Table S13. Gene #9: 'AMP PEAK 9(3P25.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 9(3P25.1) MUTATED | 30 | 1 | 35 |
| AMP PEAK 9(3P25.1) WILD-TYPE | 329 | 17 | 58 |
Figure S13. Get High-res Image Gene #9: 'AMP PEAK 9(3P25.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000607 (logrank test), Q value = 0.2
Table S14. Gene #10: 'AMP PEAK 10(3P14.1) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
| nPatients | nDeath | Duration Range (Median), Month | |
|---|---|---|---|
| ALL | 467 | 56 | 0.0 - 191.8 (20.9) |
| AMP PEAK 10(3P14.1) MUTATED | 49 | 13 | 0.1 - 191.8 (17.9) |
| AMP PEAK 10(3P14.1) WILD-TYPE | 418 | 43 | 0.0 - 185.8 (21.0) |
Figure S14. Get High-res Image Gene #10: 'AMP PEAK 10(3P14.1) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
P value = 0.000285 (Fisher's exact test), Q value = 0.098
Table S15. Gene #10: 'AMP PEAK 10(3P14.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 10(3P14.1) MUTATED | 27 | 2 | 21 |
| AMP PEAK 10(3P14.1) WILD-TYPE | 332 | 16 | 72 |
Figure S15. Get High-res Image Gene #10: 'AMP PEAK 10(3P14.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.18e-10 (t-test), Q value = 4.9e-08
Table S16. Gene #11: 'AMP PEAK 11(3Q26.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 11(3Q26.2) MUTATED | 143 | 68.5 (9.5) |
| AMP PEAK 11(3Q26.2) WILD-TYPE | 326 | 61.7 (11.4) |
Figure S16. Get High-res Image Gene #11: 'AMP PEAK 11(3Q26.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 7.81e-27 (Fisher's exact test), Q value = 3.8e-24
Table S17. Gene #11: 'AMP PEAK 11(3Q26.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 11(3Q26.2) MUTATED | 64 | 7 | 72 |
| AMP PEAK 11(3Q26.2) WILD-TYPE | 295 | 11 | 21 |
Figure S17. Get High-res Image Gene #11: 'AMP PEAK 11(3Q26.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 2.05e-08 (t-test), Q value = 8.3e-06
Table S18. Gene #12: 'AMP PEAK 12(3Q26.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 12(3Q26.2) MUTATED | 135 | 68.0 (9.6) |
| AMP PEAK 12(3Q26.2) WILD-TYPE | 334 | 62.0 (11.5) |
Figure S18. Get High-res Image Gene #12: 'AMP PEAK 12(3Q26.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.48e-26 (Fisher's exact test), Q value = 7.1e-24
Table S19. Gene #12: 'AMP PEAK 12(3Q26.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 12(3Q26.2) MUTATED | 59 | 6 | 70 |
| AMP PEAK 12(3Q26.2) WILD-TYPE | 300 | 12 | 23 |
Figure S19. Get High-res Image Gene #12: 'AMP PEAK 12(3Q26.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.79e-05 (t-test), Q value = 0.0067
Table S20. Gene #13: 'AMP PEAK 13(4P16.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 13(4P16.3) MUTATED | 43 | 70.2 (9.2) |
| AMP PEAK 13(4P16.3) WILD-TYPE | 426 | 63.1 (11.3) |
Figure S20. Get High-res Image Gene #13: 'AMP PEAK 13(4P16.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 2.76e-12 (Fisher's exact test), Q value = 1.2e-09
Table S21. Gene #13: 'AMP PEAK 13(4P16.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 13(4P16.3) MUTATED | 13 | 1 | 29 |
| AMP PEAK 13(4P16.3) WILD-TYPE | 346 | 17 | 64 |
Figure S21. Get High-res Image Gene #13: 'AMP PEAK 13(4P16.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.92e-18 (Fisher's exact test), Q value = 8.8e-16
Table S22. Gene #14: 'AMP PEAK 14(5P15.33) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 14(5P15.33) MUTATED | 25 | 3 | 45 |
| AMP PEAK 14(5P15.33) WILD-TYPE | 334 | 15 | 48 |
Figure S22. Get High-res Image Gene #14: 'AMP PEAK 14(5P15.33) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000282 (t-test), Q value = 0.097
Table S23. Gene #15: 'AMP PEAK 15(5Q35.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 15(5Q35.3) MUTATED | 44 | 69.8 (10.7) |
| AMP PEAK 15(5Q35.3) WILD-TYPE | 425 | 63.1 (11.2) |
Figure S23. Get High-res Image Gene #15: 'AMP PEAK 15(5Q35.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 2.19e-09 (Fisher's exact test), Q value = 9.1e-07
Table S24. Gene #15: 'AMP PEAK 15(5Q35.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 15(5Q35.3) MUTATED | 16 | 2 | 26 |
| AMP PEAK 15(5Q35.3) WILD-TYPE | 343 | 16 | 67 |
Figure S24. Get High-res Image Gene #15: 'AMP PEAK 15(5Q35.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.92e-06 (t-test), Q value = 0.00073
Table S25. Gene #16: 'AMP PEAK 16(6P24.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 16(6P24.2) MUTATED | 92 | 68.6 (10.3) |
| AMP PEAK 16(6P24.2) WILD-TYPE | 377 | 62.6 (11.2) |
Figure S25. Get High-res Image Gene #16: 'AMP PEAK 16(6P24.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.17e-19 (Fisher's exact test), Q value = 5.4e-17
Table S26. Gene #16: 'AMP PEAK 16(6P24.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 16(6P24.2) MUTATED | 36 | 4 | 52 |
| AMP PEAK 16(6P24.2) WILD-TYPE | 323 | 14 | 41 |
Figure S26. Get High-res Image Gene #16: 'AMP PEAK 16(6P24.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 5.31e-06 (Fisher's exact test), Q value = 0.002
Table S27. Gene #17: 'AMP PEAK 17(6Q25.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 17(6Q25.1) MUTATED | 38 | 2 | 30 |
| AMP PEAK 17(6Q25.1) WILD-TYPE | 321 | 16 | 63 |
Figure S27. Get High-res Image Gene #17: 'AMP PEAK 17(6Q25.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000598 (logrank test), Q value = 0.2
Table S28. Gene #18: 'AMP PEAK 18(7Q22.1) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
| nPatients | nDeath | Duration Range (Median), Month | |
|---|---|---|---|
| ALL | 467 | 56 | 0.0 - 191.8 (20.9) |
| AMP PEAK 18(7Q22.1) MUTATED | 75 | 16 | 0.0 - 125.4 (15.4) |
| AMP PEAK 18(7Q22.1) WILD-TYPE | 392 | 40 | 0.1 - 191.8 (23.3) |
Figure S28. Get High-res Image Gene #18: 'AMP PEAK 18(7Q22.1) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
P value = 0.000523 (logrank test), Q value = 0.18
Table S29. Gene #19: 'AMP PEAK 19(8P11.21) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
| nPatients | nDeath | Duration Range (Median), Month | |
|---|---|---|---|
| ALL | 467 | 56 | 0.0 - 191.8 (20.9) |
| AMP PEAK 19(8P11.21) MUTATED | 139 | 26 | 0.0 - 125.4 (17.9) |
| AMP PEAK 19(8P11.21) WILD-TYPE | 328 | 30 | 0.1 - 191.8 (23.4) |
Figure S29. Get High-res Image Gene #19: 'AMP PEAK 19(8P11.21) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
P value = 1.45e-07 (Fisher's exact test), Q value = 5.7e-05
Table S30. Gene #19: 'AMP PEAK 19(8P11.21) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 19(8P11.21) MUTATED | 84 | 6 | 50 |
| AMP PEAK 19(8P11.21) WILD-TYPE | 275 | 12 | 43 |
Figure S30. Get High-res Image Gene #19: 'AMP PEAK 19(8P11.21) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.00056 (logrank test), Q value = 0.19
Table S31. Gene #20: 'AMP PEAK 20(8Q24.21) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
| nPatients | nDeath | Duration Range (Median), Month | |
|---|---|---|---|
| ALL | 467 | 56 | 0.0 - 191.8 (20.9) |
| AMP PEAK 20(8Q24.21) MUTATED | 176 | 31 | 0.0 - 191.8 (17.8) |
| AMP PEAK 20(8Q24.21) WILD-TYPE | 291 | 25 | 0.1 - 185.8 (23.9) |
Figure S31. Get High-res Image Gene #20: 'AMP PEAK 20(8Q24.21) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
P value = 5.59e-14 (Fisher's exact test), Q value = 2.4e-11
Table S32. Gene #20: 'AMP PEAK 20(8Q24.21) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 20(8Q24.21) MUTATED | 102 | 8 | 67 |
| AMP PEAK 20(8Q24.21) WILD-TYPE | 257 | 10 | 26 |
Figure S32. Get High-res Image Gene #20: 'AMP PEAK 20(8Q24.21) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.84e-15 (Fisher's exact test), Q value = 8.2e-13
Table S33. Gene #21: 'AMP PEAK 21(8Q24.21) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 21(8Q24.21) MUTATED | 108 | 7 | 71 |
| AMP PEAK 21(8Q24.21) WILD-TYPE | 251 | 11 | 22 |
Figure S33. Get High-res Image Gene #21: 'AMP PEAK 21(8Q24.21) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 3.25e-09 (Fisher's exact test), Q value = 1.3e-06
Table S34. Gene #22: 'AMP PEAK 22(9P24.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 22(9P24.2) MUTATED | 22 | 2 | 29 |
| AMP PEAK 22(9P24.2) WILD-TYPE | 337 | 16 | 64 |
Figure S34. Get High-res Image Gene #22: 'AMP PEAK 22(9P24.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000194 (t-test), Q value = 0.068
Table S35. Gene #23: 'AMP PEAK 23(9Q34.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 23(9Q34.3) MUTATED | 33 | 69.7 (8.4) |
| AMP PEAK 23(9Q34.3) WILD-TYPE | 436 | 63.3 (11.4) |
Figure S35. Get High-res Image Gene #23: 'AMP PEAK 23(9Q34.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 6.89e-07 (Fisher's exact test), Q value = 0.00027
Table S36. Gene #23: 'AMP PEAK 23(9Q34.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 23(9Q34.3) MUTATED | 12 | 4 | 17 |
| AMP PEAK 23(9Q34.3) WILD-TYPE | 347 | 14 | 76 |
Figure S36. Get High-res Image Gene #23: 'AMP PEAK 23(9Q34.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 5.04e-05 (t-test), Q value = 0.018
Table S37. Gene #25: 'AMP PEAK 25(11P11.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 25(11P11.2) MUTATED | 42 | 70.0 (9.4) |
| AMP PEAK 25(11P11.2) WILD-TYPE | 427 | 63.2 (11.3) |
Figure S37. Get High-res Image Gene #25: 'AMP PEAK 25(11P11.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 6.02e-10 (Fisher's exact test), Q value = 2.5e-07
Table S38. Gene #25: 'AMP PEAK 25(11P11.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 25(11P11.2) MUTATED | 14 | 3 | 25 |
| AMP PEAK 25(11P11.2) WILD-TYPE | 345 | 15 | 68 |
Figure S38. Get High-res Image Gene #25: 'AMP PEAK 25(11P11.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 2.31e-08 (Fisher's exact test), Q value = 9.3e-06
Table S39. Gene #26: 'AMP PEAK 26(11Q13.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 26(11Q13.2) MUTATED | 29 | 2 | 31 |
| AMP PEAK 26(11Q13.2) WILD-TYPE | 330 | 16 | 62 |
Figure S39. Get High-res Image Gene #26: 'AMP PEAK 26(11Q13.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 2.34e-09 (Fisher's exact test), Q value = 9.7e-07
Table S40. Gene #27: 'AMP PEAK 27(11Q14.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 27(11Q14.1) MUTATED | 19 | 0 | 27 |
| AMP PEAK 27(11Q14.1) WILD-TYPE | 340 | 18 | 66 |
Figure S40. Get High-res Image Gene #27: 'AMP PEAK 27(11Q14.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 8.31e-09 (Fisher's exact test), Q value = 3.4e-06
Table S41. Gene #28: 'AMP PEAK 28(12P12.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 28(12P12.1) MUTATED | 36 | 2 | 35 |
| AMP PEAK 28(12P12.1) WILD-TYPE | 323 | 16 | 58 |
Figure S41. Get High-res Image Gene #28: 'AMP PEAK 28(12P12.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 4.93e-09 (Fisher's exact test), Q value = 2e-06
Table S42. Gene #29: 'AMP PEAK 29(12Q13.11) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 29(12Q13.11) MUTATED | 35 | 3 | 35 |
| AMP PEAK 29(12Q13.11) WILD-TYPE | 324 | 15 | 58 |
Figure S42. Get High-res Image Gene #29: 'AMP PEAK 29(12Q13.11) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 5.02e-08 (Fisher's exact test), Q value = 2e-05
Table S43. Gene #30: 'AMP PEAK 30(12Q13.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 30(12Q13.2) MUTATED | 42 | 3 | 36 |
| AMP PEAK 30(12Q13.2) WILD-TYPE | 317 | 15 | 57 |
Figure S43. Get High-res Image Gene #30: 'AMP PEAK 30(12Q13.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.47e-06 (t-test), Q value = 0.00057
Table S44. Gene #31: 'AMP PEAK 31(13Q34) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 31(13Q34) MUTATED | 48 | 69.7 (7.8) |
| AMP PEAK 31(13Q34) WILD-TYPE | 421 | 63.1 (11.4) |
Figure S44. Get High-res Image Gene #31: 'AMP PEAK 31(13Q34) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.98e-13 (Fisher's exact test), Q value = 8.6e-11
Table S45. Gene #31: 'AMP PEAK 31(13Q34) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 31(13Q34) MUTATED | 14 | 3 | 31 |
| AMP PEAK 31(13Q34) WILD-TYPE | 345 | 15 | 62 |
Figure S45. Get High-res Image Gene #31: 'AMP PEAK 31(13Q34) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000704 (logrank test), Q value = 0.23
Table S46. Gene #32: 'AMP PEAK 32(14Q24.3) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
| nPatients | nDeath | Duration Range (Median), Month | |
|---|---|---|---|
| ALL | 467 | 56 | 0.0 - 191.8 (20.9) |
| AMP PEAK 32(14Q24.3) MUTATED | 54 | 14 | 0.1 - 125.4 (18.1) |
| AMP PEAK 32(14Q24.3) WILD-TYPE | 413 | 42 | 0.0 - 191.8 (20.9) |
Figure S46. Get High-res Image Gene #32: 'AMP PEAK 32(14Q24.3) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
P value = 0.000179 (t-test), Q value = 0.063
Table S47. Gene #32: 'AMP PEAK 32(14Q24.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 32(14Q24.3) MUTATED | 54 | 68.6 (9.4) |
| AMP PEAK 32(14Q24.3) WILD-TYPE | 415 | 63.1 (11.4) |
Figure S47. Get High-res Image Gene #32: 'AMP PEAK 32(14Q24.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 8.71e-13 (Fisher's exact test), Q value = 3.8e-10
Table S48. Gene #32: 'AMP PEAK 32(14Q24.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 32(14Q24.3) MUTATED | 18 | 4 | 32 |
| AMP PEAK 32(14Q24.3) WILD-TYPE | 341 | 14 | 61 |
Figure S48. Get High-res Image Gene #32: 'AMP PEAK 32(14Q24.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000148 (Fisher's exact test), Q value = 0.052
Table S49. Gene #33: 'AMP PEAK 33(15Q26.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 33(15Q26.3) MUTATED | 15 | 0 | 16 |
| AMP PEAK 33(15Q26.3) WILD-TYPE | 344 | 18 | 77 |
Figure S49. Get High-res Image Gene #33: 'AMP PEAK 33(15Q26.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 5e-05 (t-test), Q value = 0.018
Table S50. Gene #34: 'AMP PEAK 34(16P11.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 34(16P11.2) MUTATED | 53 | 68.8 (8.6) |
| AMP PEAK 34(16P11.2) WILD-TYPE | 416 | 63.1 (11.4) |
Figure S50. Get High-res Image Gene #34: 'AMP PEAK 34(16P11.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 6.29e-14 (Fisher's exact test), Q value = 2.7e-11
Table S51. Gene #34: 'AMP PEAK 34(16P11.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 34(16P11.2) MUTATED | 17 | 2 | 34 |
| AMP PEAK 34(16P11.2) WILD-TYPE | 342 | 16 | 59 |
Figure S51. Get High-res Image Gene #34: 'AMP PEAK 34(16P11.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000516 (t-test), Q value = 0.17
Table S52. Gene #35: 'AMP PEAK 35(17Q11.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 35(17Q11.2) MUTATED | 60 | 67.8 (9.0) |
| AMP PEAK 35(17Q11.2) WILD-TYPE | 409 | 63.2 (11.5) |
Figure S52. Get High-res Image Gene #35: 'AMP PEAK 35(17Q11.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 4.96e-20 (Fisher's exact test), Q value = 2.3e-17
Table S53. Gene #35: 'AMP PEAK 35(17Q11.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 35(17Q11.2) MUTATED | 15 | 5 | 40 |
| AMP PEAK 35(17Q11.2) WILD-TYPE | 344 | 13 | 53 |
Figure S53. Get High-res Image Gene #35: 'AMP PEAK 35(17Q11.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000339 (logrank test), Q value = 0.12
Table S54. Gene #36: 'AMP PEAK 36(17Q12) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
| nPatients | nDeath | Duration Range (Median), Month | |
|---|---|---|---|
| ALL | 467 | 56 | 0.0 - 191.8 (20.9) |
| AMP PEAK 36(17Q12) MUTATED | 61 | 14 | 0.1 - 97.4 (16.9) |
| AMP PEAK 36(17Q12) WILD-TYPE | 406 | 42 | 0.0 - 191.8 (22.6) |
Figure S54. Get High-res Image Gene #36: 'AMP PEAK 36(17Q12) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
P value = 4.66e-05 (t-test), Q value = 0.017
Table S55. Gene #36: 'AMP PEAK 36(17Q12) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 36(17Q12) MUTATED | 62 | 68.8 (9.6) |
| AMP PEAK 36(17Q12) WILD-TYPE | 407 | 63.0 (11.3) |
Figure S55. Get High-res Image Gene #36: 'AMP PEAK 36(17Q12) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.19e-19 (Fisher's exact test), Q value = 5.5e-17
Table S56. Gene #36: 'AMP PEAK 36(17Q12) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 36(17Q12) MUTATED | 17 | 3 | 42 |
| AMP PEAK 36(17Q12) WILD-TYPE | 342 | 15 | 51 |
Figure S56. Get High-res Image Gene #36: 'AMP PEAK 36(17Q12) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 7.77e-05 (t-test), Q value = 0.028
Table S57. Gene #37: 'AMP PEAK 37(17Q25.1) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 37(17Q25.1) MUTATED | 84 | 67.8 (9.6) |
| AMP PEAK 37(17Q25.1) WILD-TYPE | 385 | 62.9 (11.4) |
Figure S57. Get High-res Image Gene #37: 'AMP PEAK 37(17Q25.1) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 6.71e-17 (Fisher's exact test), Q value = 3e-14
Table S58. Gene #37: 'AMP PEAK 37(17Q25.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 37(17Q25.1) MUTATED | 32 | 8 | 44 |
| AMP PEAK 37(17Q25.1) WILD-TYPE | 327 | 10 | 49 |
Figure S58. Get High-res Image Gene #37: 'AMP PEAK 37(17Q25.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000173 (t-test), Q value = 0.061
Table S59. Gene #38: 'AMP PEAK 38(18P11.31) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 38(18P11.31) MUTATED | 75 | 67.7 (9.3) |
| AMP PEAK 38(18P11.31) WILD-TYPE | 394 | 63.0 (11.5) |
Figure S59. Get High-res Image Gene #38: 'AMP PEAK 38(18P11.31) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.47e-21 (Fisher's exact test), Q value = 6.9e-19
Table S60. Gene #38: 'AMP PEAK 38(18P11.31) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 38(18P11.31) MUTATED | 23 | 4 | 48 |
| AMP PEAK 38(18P11.31) WILD-TYPE | 336 | 14 | 45 |
Figure S60. Get High-res Image Gene #38: 'AMP PEAK 38(18P11.31) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.93e-16 (Fisher's exact test), Q value = 8.6e-14
Table S61. Gene #39: 'AMP PEAK 39(18Q11.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 39(18Q11.2) MUTATED | 18 | 3 | 38 |
| AMP PEAK 39(18Q11.2) WILD-TYPE | 341 | 15 | 55 |
Figure S61. Get High-res Image Gene #39: 'AMP PEAK 39(18Q11.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 3.11e-11 (t-test), Q value = 1.3e-08
Table S62. Gene #40: 'AMP PEAK 40(19P13.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 40(19P13.2) MUTATED | 76 | 70.7 (8.7) |
| AMP PEAK 40(19P13.2) WILD-TYPE | 393 | 62.4 (11.3) |
Figure S62. Get High-res Image Gene #40: 'AMP PEAK 40(19P13.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 3.37e-20 (Fisher's exact test), Q value = 1.6e-17
Table S63. Gene #40: 'AMP PEAK 40(19P13.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 40(19P13.2) MUTATED | 24 | 7 | 45 |
| AMP PEAK 40(19P13.2) WILD-TYPE | 335 | 11 | 48 |
Figure S63. Get High-res Image Gene #40: 'AMP PEAK 40(19P13.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.01e-10 (t-test), Q value = 4.3e-08
Table S64. Gene #41: 'AMP PEAK 41(19P13.11) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 41(19P13.11) MUTATED | 78 | 70.7 (9.1) |
| AMP PEAK 41(19P13.11) WILD-TYPE | 391 | 62.4 (11.2) |
Figure S64. Get High-res Image Gene #41: 'AMP PEAK 41(19P13.11) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 3.08e-23 (Fisher's exact test), Q value = 1.5e-20
Table S65. Gene #41: 'AMP PEAK 41(19P13.11) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 41(19P13.11) MUTATED | 23 | 6 | 49 |
| AMP PEAK 41(19P13.11) WILD-TYPE | 336 | 12 | 44 |
Figure S65. Get High-res Image Gene #41: 'AMP PEAK 41(19P13.11) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000294 (logrank test), Q value = 0.1
Table S66. Gene #42: 'AMP PEAK 42(19Q12) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
| nPatients | nDeath | Duration Range (Median), Month | |
|---|---|---|---|
| ALL | 467 | 56 | 0.0 - 191.8 (20.9) |
| AMP PEAK 42(19Q12) MUTATED | 94 | 20 | 0.0 - 125.4 (17.3) |
| AMP PEAK 42(19Q12) WILD-TYPE | 373 | 36 | 0.1 - 191.8 (23.0) |
Figure S66. Get High-res Image Gene #42: 'AMP PEAK 42(19Q12) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
P value = 2.62e-09 (t-test), Q value = 1.1e-06
Table S67. Gene #42: 'AMP PEAK 42(19Q12) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 42(19Q12) MUTATED | 94 | 69.2 (8.8) |
| AMP PEAK 42(19Q12) WILD-TYPE | 375 | 62.4 (11.5) |
Figure S67. Get High-res Image Gene #42: 'AMP PEAK 42(19Q12) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 2.16e-38 (Fisher's exact test), Q value = 1.1e-35
Table S68. Gene #42: 'AMP PEAK 42(19Q12) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 42(19Q12) MUTATED | 21 | 9 | 64 |
| AMP PEAK 42(19Q12) WILD-TYPE | 338 | 9 | 29 |
Figure S68. Get High-res Image Gene #42: 'AMP PEAK 42(19Q12) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 2.23e-05 (t-test), Q value = 0.0082
Table S69. Gene #43: 'AMP PEAK 43(20P13) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 43(20P13) MUTATED | 96 | 68.3 (11.4) |
| AMP PEAK 43(20P13) WILD-TYPE | 373 | 62.6 (11.0) |
Figure S69. Get High-res Image Gene #43: 'AMP PEAK 43(20P13) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.19e-12 (Fisher's exact test), Q value = 5.1e-10
Table S70. Gene #43: 'AMP PEAK 43(20P13) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 43(20P13) MUTATED | 46 | 4 | 46 |
| AMP PEAK 43(20P13) WILD-TYPE | 313 | 14 | 47 |
Figure S70. Get High-res Image Gene #43: 'AMP PEAK 43(20P13) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000368 (logrank test), Q value = 0.13
Table S71. Gene #44: 'AMP PEAK 44(20Q11.21) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
| nPatients | nDeath | Duration Range (Median), Month | |
|---|---|---|---|
| ALL | 467 | 56 | 0.0 - 191.8 (20.9) |
| AMP PEAK 44(20Q11.21) MUTATED | 117 | 23 | 0.0 - 149.5 (15.4) |
| AMP PEAK 44(20Q11.21) WILD-TYPE | 350 | 33 | 0.1 - 191.8 (23.3) |
Figure S71. Get High-res Image Gene #44: 'AMP PEAK 44(20Q11.21) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
P value = 6.22e-08 (t-test), Q value = 2.5e-05
Table S72. Gene #44: 'AMP PEAK 44(20Q11.21) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 44(20Q11.21) MUTATED | 118 | 68.3 (9.9) |
| AMP PEAK 44(20Q11.21) WILD-TYPE | 351 | 62.2 (11.3) |
Figure S72. Get High-res Image Gene #44: 'AMP PEAK 44(20Q11.21) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 5.04e-25 (Fisher's exact test), Q value = 2.4e-22
Table S73. Gene #44: 'AMP PEAK 44(20Q11.21) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 44(20Q11.21) MUTATED | 48 | 6 | 64 |
| AMP PEAK 44(20Q11.21) WILD-TYPE | 311 | 12 | 29 |
Figure S73. Get High-res Image Gene #44: 'AMP PEAK 44(20Q11.21) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.54e-08 (t-test), Q value = 6.3e-06
Table S74. Gene #45: 'AMP PEAK 45(20Q13.12) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 45(20Q13.12) MUTATED | 125 | 68.5 (10.2) |
| AMP PEAK 45(20Q13.12) WILD-TYPE | 344 | 62.1 (11.2) |
Figure S74. Get High-res Image Gene #45: 'AMP PEAK 45(20Q13.12) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 2.09e-23 (Fisher's exact test), Q value = 1e-20
Table S75. Gene #45: 'AMP PEAK 45(20Q13.12) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 45(20Q13.12) MUTATED | 54 | 7 | 64 |
| AMP PEAK 45(20Q13.12) WILD-TYPE | 305 | 11 | 29 |
Figure S75. Get High-res Image Gene #45: 'AMP PEAK 45(20Q13.12) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 7.89e-08 (t-test), Q value = 3.1e-05
Table S76. Gene #46: 'AMP PEAK 46(20Q13.33) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| AMP PEAK 46(20Q13.33) MUTATED | 121 | 68.4 (10.4) |
| AMP PEAK 46(20Q13.33) WILD-TYPE | 348 | 62.2 (11.2) |
Figure S76. Get High-res Image Gene #46: 'AMP PEAK 46(20Q13.33) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.09e-18 (Fisher's exact test), Q value = 5e-16
Table S77. Gene #46: 'AMP PEAK 46(20Q13.33) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 46(20Q13.33) MUTATED | 56 | 6 | 59 |
| AMP PEAK 46(20Q13.33) WILD-TYPE | 303 | 12 | 34 |
Figure S77. Get High-res Image Gene #46: 'AMP PEAK 46(20Q13.33) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.42e-20 (Fisher's exact test), Q value = 6.7e-18
Table S78. Gene #47: 'AMP PEAK 47(22Q12.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| AMP PEAK 47(22Q12.2) MUTATED | 11 | 2 | 39 |
| AMP PEAK 47(22Q12.2) WILD-TYPE | 348 | 16 | 54 |
Figure S78. Get High-res Image Gene #47: 'AMP PEAK 47(22Q12.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000681 (Fisher's exact test), Q value = 0.22
Table S79. Gene #47: 'AMP PEAK 47(22Q12.2) MUTATION STATUS' versus Clinical Feature #5: 'COMPLETENESS.OF.RESECTION'
| nPatients | R0 | R1 | R2 | RX |
|---|---|---|---|---|
| ALL | 324 | 24 | 16 | 26 |
| AMP PEAK 47(22Q12.2) MUTATED | 28 | 2 | 7 | 5 |
| AMP PEAK 47(22Q12.2) WILD-TYPE | 296 | 22 | 9 | 21 |
Figure S79. Get High-res Image Gene #47: 'AMP PEAK 47(22Q12.2) MUTATION STATUS' versus Clinical Feature #5: 'COMPLETENESS.OF.RESECTION'
P value = 1.6e-05 (t-test), Q value = 0.006
Table S80. Gene #50: 'DEL PEAK 1(1P36.11) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 1(1P36.11) MUTATED | 68 | 68.9 (9.8) |
| DEL PEAK 1(1P36.11) WILD-TYPE | 401 | 62.9 (11.3) |
Figure S80. Get High-res Image Gene #50: 'DEL PEAK 1(1P36.11) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.58e-15 (Fisher's exact test), Q value = 7e-13
Table S81. Gene #50: 'DEL PEAK 1(1P36.11) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 1(1P36.11) MUTATED | 24 | 4 | 40 |
| DEL PEAK 1(1P36.11) WILD-TYPE | 335 | 14 | 53 |
Figure S81. Get High-res Image Gene #50: 'DEL PEAK 1(1P36.11) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.16e-10 (logrank test), Q value = 4.9e-08
Table S82. Gene #52: 'DEL PEAK 3(2Q22.1) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
| nPatients | nDeath | Duration Range (Median), Month | |
|---|---|---|---|
| ALL | 467 | 56 | 0.0 - 191.8 (20.9) |
| DEL PEAK 3(2Q22.1) MUTATED | 42 | 15 | 0.1 - 125.4 (9.8) |
| DEL PEAK 3(2Q22.1) WILD-TYPE | 425 | 41 | 0.0 - 191.8 (23.3) |
Figure S82. Get High-res Image Gene #52: 'DEL PEAK 3(2Q22.1) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
P value = 8.59e-09 (Fisher's exact test), Q value = 3.5e-06
Table S83. Gene #52: 'DEL PEAK 3(2Q22.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 3(2Q22.1) MUTATED | 16 | 1 | 25 |
| DEL PEAK 3(2Q22.1) WILD-TYPE | 343 | 17 | 68 |
Figure S83. Get High-res Image Gene #52: 'DEL PEAK 3(2Q22.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000477 (t-test), Q value = 0.16
Table S84. Gene #53: 'DEL PEAK 4(2Q37.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 4(2Q37.3) MUTATED | 46 | 68.3 (8.4) |
| DEL PEAK 4(2Q37.3) WILD-TYPE | 423 | 63.3 (11.5) |
Figure S84. Get High-res Image Gene #53: 'DEL PEAK 4(2Q37.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 0.000129 (t-test), Q value = 0.046
Table S85. Gene #54: 'DEL PEAK 5(3P14.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 5(3P14.2) MUTATED | 65 | 67.8 (8.4) |
| DEL PEAK 5(3P14.2) WILD-TYPE | 404 | 63.1 (11.6) |
Figure S85. Get High-res Image Gene #54: 'DEL PEAK 5(3P14.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 3.02e-16 (Fisher's exact test), Q value = 1.3e-13
Table S86. Gene #54: 'DEL PEAK 5(3P14.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 5(3P14.2) MUTATED | 21 | 6 | 38 |
| DEL PEAK 5(3P14.2) WILD-TYPE | 338 | 12 | 55 |
Figure S86. Get High-res Image Gene #54: 'DEL PEAK 5(3P14.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.67e-06 (Fisher's exact test), Q value = 0.00064
Table S87. Gene #55: 'DEL PEAK 6(3Q13.31) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 6(3Q13.31) MUTATED | 8 | 1 | 16 |
| DEL PEAK 6(3Q13.31) WILD-TYPE | 351 | 17 | 77 |
Figure S87. Get High-res Image Gene #55: 'DEL PEAK 6(3Q13.31) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 8.5e-05 (t-test), Q value = 0.03
Table S88. Gene #56: 'DEL PEAK 7(4P16.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 7(4P16.3) MUTATED | 75 | 67.9 (9.3) |
| DEL PEAK 7(4P16.3) WILD-TYPE | 394 | 63.0 (11.5) |
Figure S88. Get High-res Image Gene #56: 'DEL PEAK 7(4P16.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 4.35e-17 (Fisher's exact test), Q value = 2e-14
Table S89. Gene #56: 'DEL PEAK 7(4P16.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 7(4P16.3) MUTATED | 27 | 4 | 44 |
| DEL PEAK 7(4P16.3) WILD-TYPE | 332 | 14 | 49 |
Figure S89. Get High-res Image Gene #56: 'DEL PEAK 7(4P16.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 3.51e-05 (t-test), Q value = 0.013
Table S90. Gene #57: 'DEL PEAK 8(4P15.31) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 8(4P15.31) MUTATED | 77 | 68.1 (9.4) |
| DEL PEAK 8(4P15.31) WILD-TYPE | 392 | 62.9 (11.4) |
Figure S90. Get High-res Image Gene #57: 'DEL PEAK 8(4P15.31) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 6.46e-17 (Fisher's exact test), Q value = 2.9e-14
Table S91. Gene #57: 'DEL PEAK 8(4P15.31) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 8(4P15.31) MUTATED | 29 | 3 | 45 |
| DEL PEAK 8(4P15.31) WILD-TYPE | 330 | 15 | 48 |
Figure S91. Get High-res Image Gene #57: 'DEL PEAK 8(4P15.31) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 4.86e-06 (t-test), Q value = 0.0018
Table S92. Gene #58: 'DEL PEAK 9(4Q22.1) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 9(4Q22.1) MUTATED | 85 | 68.3 (9.2) |
| DEL PEAK 9(4Q22.1) WILD-TYPE | 384 | 62.8 (11.5) |
Figure S92. Get High-res Image Gene #58: 'DEL PEAK 9(4Q22.1) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.68e-26 (Fisher's exact test), Q value = 8.1e-24
Table S93. Gene #58: 'DEL PEAK 9(4Q22.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 9(4Q22.1) MUTATED | 25 | 5 | 55 |
| DEL PEAK 9(4Q22.1) WILD-TYPE | 334 | 13 | 38 |
Figure S93. Get High-res Image Gene #58: 'DEL PEAK 9(4Q22.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 6e-06 (t-test), Q value = 0.0023
Table S94. Gene #59: 'DEL PEAK 10(4Q34.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 10(4Q34.3) MUTATED | 105 | 68.0 (10.2) |
| DEL PEAK 10(4Q34.3) WILD-TYPE | 364 | 62.6 (11.3) |
Figure S94. Get High-res Image Gene #59: 'DEL PEAK 10(4Q34.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.95e-27 (Fisher's exact test), Q value = 9.5e-25
Table S95. Gene #59: 'DEL PEAK 10(4Q34.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 10(4Q34.3) MUTATED | 37 | 6 | 62 |
| DEL PEAK 10(4Q34.3) WILD-TYPE | 322 | 12 | 31 |
Figure S95. Get High-res Image Gene #59: 'DEL PEAK 10(4Q34.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 6.22e-05 (t-test), Q value = 0.022
Table S96. Gene #60: 'DEL PEAK 11(5Q11.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 11(5Q11.2) MUTATED | 90 | 67.8 (10.1) |
| DEL PEAK 11(5Q11.2) WILD-TYPE | 379 | 62.8 (11.4) |
Figure S96. Get High-res Image Gene #60: 'DEL PEAK 11(5Q11.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 2.4e-25 (Fisher's exact test), Q value = 1.2e-22
Table S97. Gene #60: 'DEL PEAK 11(5Q11.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 11(5Q11.2) MUTATED | 31 | 2 | 57 |
| DEL PEAK 11(5Q11.2) WILD-TYPE | 328 | 16 | 36 |
Figure S97. Get High-res Image Gene #60: 'DEL PEAK 11(5Q11.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 3.5e-11 (Fisher's exact test), Q value = 1.5e-08
Table S98. Gene #61: 'DEL PEAK 12(6Q26) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 12(6Q26) MUTATED | 12 | 3 | 26 |
| DEL PEAK 12(6Q26) WILD-TYPE | 347 | 15 | 67 |
Figure S98. Get High-res Image Gene #61: 'DEL PEAK 12(6Q26) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000434 (logrank test), Q value = 0.15
Table S99. Gene #62: 'DEL PEAK 13(7P22.3) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
| nPatients | nDeath | Duration Range (Median), Month | |
|---|---|---|---|
| ALL | 467 | 56 | 0.0 - 191.8 (20.9) |
| DEL PEAK 13(7P22.3) MUTATED | 63 | 15 | 0.0 - 97.7 (18.2) |
| DEL PEAK 13(7P22.3) WILD-TYPE | 404 | 41 | 0.1 - 191.8 (21.8) |
Figure S99. Get High-res Image Gene #62: 'DEL PEAK 13(7P22.3) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
P value = 6.1e-05 (t-test), Q value = 0.022
Table S100. Gene #62: 'DEL PEAK 13(7P22.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 13(7P22.3) MUTATED | 63 | 68.8 (10.1) |
| DEL PEAK 13(7P22.3) WILD-TYPE | 406 | 63.0 (11.3) |
Figure S100. Get High-res Image Gene #62: 'DEL PEAK 13(7P22.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.18e-14 (Fisher's exact test), Q value = 5.2e-12
Table S101. Gene #62: 'DEL PEAK 13(7P22.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 13(7P22.3) MUTATED | 22 | 5 | 37 |
| DEL PEAK 13(7P22.3) WILD-TYPE | 337 | 13 | 56 |
Figure S101. Get High-res Image Gene #62: 'DEL PEAK 13(7P22.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 2.65e-05 (t-test), Q value = 0.0097
Table S102. Gene #63: 'DEL PEAK 14(7Q11.22) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 14(7Q11.22) MUTATED | 37 | 71.1 (9.8) |
| DEL PEAK 14(7Q11.22) WILD-TYPE | 432 | 63.1 (11.2) |
Figure S102. Get High-res Image Gene #63: 'DEL PEAK 14(7Q11.22) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 2.72e-08 (Fisher's exact test), Q value = 1.1e-05
Table S103. Gene #63: 'DEL PEAK 14(7Q11.22) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 14(7Q11.22) MUTATED | 13 | 2 | 22 |
| DEL PEAK 14(7Q11.22) WILD-TYPE | 346 | 16 | 71 |
Figure S103. Get High-res Image Gene #63: 'DEL PEAK 14(7Q11.22) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 7.14e-07 (t-test), Q value = 0.00028
Table S104. Gene #64: 'DEL PEAK 15(7Q31.1) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 15(7Q31.1) MUTATED | 46 | 70.2 (7.9) |
| DEL PEAK 15(7Q31.1) WILD-TYPE | 423 | 63.1 (11.4) |
Figure S104. Get High-res Image Gene #64: 'DEL PEAK 15(7Q31.1) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 2.99e-18 (Fisher's exact test), Q value = 1.4e-15
Table S105. Gene #64: 'DEL PEAK 15(7Q31.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 15(7Q31.1) MUTATED | 9 | 3 | 34 |
| DEL PEAK 15(7Q31.1) WILD-TYPE | 350 | 15 | 59 |
Figure S105. Get High-res Image Gene #64: 'DEL PEAK 15(7Q31.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.22e-09 (t-test), Q value = 5.1e-07
Table S106. Gene #65: 'DEL PEAK 16(7Q36.1) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 16(7Q36.1) MUTATED | 56 | 71.4 (8.5) |
| DEL PEAK 16(7Q36.1) WILD-TYPE | 413 | 62.7 (11.2) |
Figure S106. Get High-res Image Gene #65: 'DEL PEAK 16(7Q36.1) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 3.46e-21 (Fisher's exact test), Q value = 1.6e-18
Table S107. Gene #65: 'DEL PEAK 16(7Q36.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 16(7Q36.1) MUTATED | 12 | 4 | 40 |
| DEL PEAK 16(7Q36.1) WILD-TYPE | 347 | 14 | 53 |
Figure S107. Get High-res Image Gene #65: 'DEL PEAK 16(7Q36.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000249 (t-test), Q value = 0.087
Table S108. Gene #66: 'DEL PEAK 17(8P23.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 17(8P23.2) MUTATED | 95 | 67.1 (9.4) |
| DEL PEAK 17(8P23.2) WILD-TYPE | 374 | 62.9 (11.6) |
Figure S108. Get High-res Image Gene #66: 'DEL PEAK 17(8P23.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 5.28e-30 (Fisher's exact test), Q value = 2.6e-27
Table S109. Gene #66: 'DEL PEAK 17(8P23.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 17(8P23.2) MUTATED | 30 | 4 | 62 |
| DEL PEAK 17(8P23.2) WILD-TYPE | 329 | 14 | 31 |
Figure S109. Get High-res Image Gene #66: 'DEL PEAK 17(8P23.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 7.73e-06 (t-test), Q value = 0.0029
Table S110. Gene #67: 'DEL PEAK 18(8P21.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 18(8P21.2) MUTATED | 94 | 67.9 (9.2) |
| DEL PEAK 18(8P21.2) WILD-TYPE | 375 | 62.7 (11.5) |
Figure S110. Get High-res Image Gene #67: 'DEL PEAK 18(8P21.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.67e-37 (Fisher's exact test), Q value = 8.1e-35
Table S111. Gene #67: 'DEL PEAK 18(8P21.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 18(8P21.2) MUTATED | 23 | 5 | 66 |
| DEL PEAK 18(8P21.2) WILD-TYPE | 336 | 13 | 27 |
Figure S111. Get High-res Image Gene #67: 'DEL PEAK 18(8P21.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.21e-11 (Fisher's exact test), Q value = 5.2e-09
Table S112. Gene #68: 'DEL PEAK 19(9P23) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 19(9P23) MUTATED | 22 | 3 | 33 |
| DEL PEAK 19(9P23) WILD-TYPE | 337 | 15 | 60 |
Figure S112. Get High-res Image Gene #68: 'DEL PEAK 19(9P23) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000763 (logrank test), Q value = 0.25
Table S113. Gene #69: 'DEL PEAK 20(9Q21.2) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
| nPatients | nDeath | Duration Range (Median), Month | |
|---|---|---|---|
| ALL | 467 | 56 | 0.0 - 191.8 (20.9) |
| DEL PEAK 20(9Q21.2) MUTATED | 103 | 21 | 0.1 - 125.4 (16.9) |
| DEL PEAK 20(9Q21.2) WILD-TYPE | 364 | 35 | 0.0 - 191.8 (23.1) |
Figure S113. Get High-res Image Gene #69: 'DEL PEAK 20(9Q21.2) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
P value = 3.62e-11 (t-test), Q value = 1.5e-08
Table S114. Gene #69: 'DEL PEAK 20(9Q21.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 20(9Q21.2) MUTATED | 104 | 69.6 (9.2) |
| DEL PEAK 20(9Q21.2) WILD-TYPE | 365 | 62.1 (11.3) |
Figure S114. Get High-res Image Gene #69: 'DEL PEAK 20(9Q21.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 3.28e-20 (Fisher's exact test), Q value = 1.5e-17
Table S115. Gene #69: 'DEL PEAK 20(9Q21.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 20(9Q21.2) MUTATED | 42 | 8 | 54 |
| DEL PEAK 20(9Q21.2) WILD-TYPE | 317 | 10 | 39 |
Figure S115. Get High-res Image Gene #69: 'DEL PEAK 20(9Q21.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 3.8e-08 (t-test), Q value = 1.5e-05
Table S116. Gene #70: 'DEL PEAK 21(9Q34.11) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 21(9Q34.11) MUTATED | 109 | 68.4 (9.1) |
| DEL PEAK 21(9Q34.11) WILD-TYPE | 360 | 62.4 (11.5) |
Figure S116. Get High-res Image Gene #70: 'DEL PEAK 21(9Q34.11) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.39e-18 (Fisher's exact test), Q value = 6.4e-16
Table S117. Gene #70: 'DEL PEAK 21(9Q34.11) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 21(9Q34.11) MUTATED | 47 | 8 | 54 |
| DEL PEAK 21(9Q34.11) WILD-TYPE | 312 | 10 | 39 |
Figure S117. Get High-res Image Gene #70: 'DEL PEAK 21(9Q34.11) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.03e-08 (Fisher's exact test), Q value = 4.2e-06
Table S118. Gene #71: 'DEL PEAK 22(10Q23.31) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 22(10Q23.31) MUTATED | 28 | 3 | 31 |
| DEL PEAK 22(10Q23.31) WILD-TYPE | 331 | 15 | 62 |
Figure S118. Get High-res Image Gene #71: 'DEL PEAK 22(10Q23.31) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.52e-06 (t-test), Q value = 0.00058
Table S119. Gene #72: 'DEL PEAK 23(11P15.5) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 23(11P15.5) MUTATED | 83 | 68.6 (9.3) |
| DEL PEAK 23(11P15.5) WILD-TYPE | 386 | 62.7 (11.4) |
Figure S119. Get High-res Image Gene #72: 'DEL PEAK 23(11P15.5) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.14e-18 (Fisher's exact test), Q value = 5.2e-16
Table S120. Gene #72: 'DEL PEAK 23(11P15.5) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 23(11P15.5) MUTATED | 30 | 6 | 47 |
| DEL PEAK 23(11P15.5) WILD-TYPE | 329 | 12 | 46 |
Figure S120. Get High-res Image Gene #72: 'DEL PEAK 23(11P15.5) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.76e-05 (t-test), Q value = 0.0066
Table S121. Gene #73: 'DEL PEAK 24(11Q14.1) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 24(11Q14.1) MUTATED | 57 | 69.0 (8.9) |
| DEL PEAK 24(11Q14.1) WILD-TYPE | 412 | 63.0 (11.4) |
Figure S121. Get High-res Image Gene #73: 'DEL PEAK 24(11Q14.1) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 2.63e-15 (Fisher's exact test), Q value = 1.2e-12
Table S122. Gene #73: 'DEL PEAK 24(11Q14.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 24(11Q14.1) MUTATED | 17 | 6 | 34 |
| DEL PEAK 24(11Q14.1) WILD-TYPE | 342 | 12 | 59 |
Figure S122. Get High-res Image Gene #73: 'DEL PEAK 24(11Q14.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000599 (t-test), Q value = 0.2
Table S123. Gene #74: 'DEL PEAK 25(11Q25) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 25(11Q25) MUTATED | 78 | 67.6 (10.4) |
| DEL PEAK 25(11Q25) WILD-TYPE | 391 | 63.0 (11.3) |
Figure S123. Get High-res Image Gene #74: 'DEL PEAK 25(11Q25) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.31e-16 (Fisher's exact test), Q value = 5.9e-14
Table S124. Gene #74: 'DEL PEAK 25(11Q25) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 25(11Q25) MUTATED | 29 | 5 | 44 |
| DEL PEAK 25(11Q25) WILD-TYPE | 330 | 13 | 49 |
Figure S124. Get High-res Image Gene #74: 'DEL PEAK 25(11Q25) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.51e-12 (Fisher's exact test), Q value = 6.5e-10
Table S125. Gene #75: 'DEL PEAK 26(12Q23.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 26(12Q23.1) MUTATED | 11 | 1 | 28 |
| DEL PEAK 26(12Q23.1) WILD-TYPE | 348 | 17 | 65 |
Figure S125. Get High-res Image Gene #75: 'DEL PEAK 26(12Q23.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 6.99e-05 (t-test), Q value = 0.025
Table S126. Gene #76: 'DEL PEAK 27(12Q24.33) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 27(12Q24.33) MUTATED | 52 | 68.9 (9.0) |
| DEL PEAK 27(12Q24.33) WILD-TYPE | 417 | 63.1 (11.4) |
Figure S126. Get High-res Image Gene #76: 'DEL PEAK 27(12Q24.33) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 3.41e-15 (Fisher's exact test), Q value = 1.5e-12
Table S127. Gene #76: 'DEL PEAK 27(12Q24.33) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 27(12Q24.33) MUTATED | 16 | 1 | 35 |
| DEL PEAK 27(12Q24.33) WILD-TYPE | 343 | 17 | 58 |
Figure S127. Get High-res Image Gene #76: 'DEL PEAK 27(12Q24.33) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 9.14e-13 (Fisher's exact test), Q value = 4e-10
Table S128. Gene #77: 'DEL PEAK 28(13Q11) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 28(13Q11) MUTATED | 34 | 3 | 41 |
| DEL PEAK 28(13Q11) WILD-TYPE | 325 | 15 | 52 |
Figure S128. Get High-res Image Gene #77: 'DEL PEAK 28(13Q11) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000395 (t-test), Q value = 0.13
Table S129. Gene #78: 'DEL PEAK 29(13Q14.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 29(13Q14.2) MUTATED | 83 | 67.5 (10.0) |
| DEL PEAK 29(13Q14.2) WILD-TYPE | 386 | 63.0 (11.4) |
Figure S129. Get High-res Image Gene #78: 'DEL PEAK 29(13Q14.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 2.98e-07 (Fisher's exact test), Q value = 0.00012
Table S130. Gene #78: 'DEL PEAK 29(13Q14.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 29(13Q14.2) MUTATED | 44 | 4 | 35 |
| DEL PEAK 29(13Q14.2) WILD-TYPE | 315 | 14 | 58 |
Figure S130. Get High-res Image Gene #78: 'DEL PEAK 29(13Q14.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 8.22e-11 (Fisher's exact test), Q value = 3.5e-08
Table S131. Gene #79: 'DEL PEAK 30(14Q13.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 30(14Q13.1) MUTATED | 23 | 5 | 31 |
| DEL PEAK 30(14Q13.1) WILD-TYPE | 336 | 13 | 62 |
Figure S131. Get High-res Image Gene #79: 'DEL PEAK 30(14Q13.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 5.86e-08 (t-test), Q value = 2.3e-05
Table S132. Gene #80: 'DEL PEAK 31(15Q15.1) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 31(15Q15.1) MUTATED | 115 | 68.4 (9.9) |
| DEL PEAK 31(15Q15.1) WILD-TYPE | 354 | 62.2 (11.3) |
Figure S132. Get High-res Image Gene #80: 'DEL PEAK 31(15Q15.1) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 3.86e-23 (Fisher's exact test), Q value = 1.8e-20
Table S133. Gene #80: 'DEL PEAK 31(15Q15.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 31(15Q15.1) MUTATED | 47 | 7 | 61 |
| DEL PEAK 31(15Q15.1) WILD-TYPE | 312 | 11 | 32 |
Figure S133. Get High-res Image Gene #80: 'DEL PEAK 31(15Q15.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 2e-05 (t-test), Q value = 0.0074
Table S134. Gene #81: 'DEL PEAK 32(15Q23) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 32(15Q23) MUTATED | 96 | 67.8 (9.7) |
| DEL PEAK 32(15Q23) WILD-TYPE | 373 | 62.7 (11.4) |
Figure S134. Get High-res Image Gene #81: 'DEL PEAK 32(15Q23) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 4.74e-23 (Fisher's exact test), Q value = 2.2e-20
Table S135. Gene #81: 'DEL PEAK 32(15Q23) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 32(15Q23) MUTATED | 35 | 5 | 56 |
| DEL PEAK 32(15Q23) WILD-TYPE | 324 | 13 | 37 |
Figure S135. Get High-res Image Gene #81: 'DEL PEAK 32(15Q23) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.81e-07 (t-test), Q value = 7.1e-05
Table S136. Gene #82: 'DEL PEAK 33(16P13.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 33(16P13.3) MUTATED | 73 | 69.3 (8.8) |
| DEL PEAK 33(16P13.3) WILD-TYPE | 396 | 62.7 (11.4) |
Figure S136. Get High-res Image Gene #82: 'DEL PEAK 33(16P13.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 4.39e-20 (Fisher's exact test), Q value = 2e-17
Table S137. Gene #82: 'DEL PEAK 33(16P13.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 33(16P13.3) MUTATED | 23 | 4 | 46 |
| DEL PEAK 33(16P13.3) WILD-TYPE | 336 | 14 | 47 |
Figure S137. Get High-res Image Gene #82: 'DEL PEAK 33(16P13.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 8.28e-09 (t-test), Q value = 3.4e-06
Table S138. Gene #83: 'DEL PEAK 34(16Q21) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 34(16Q21) MUTATED | 129 | 68.2 (9.4) |
| DEL PEAK 34(16Q21) WILD-TYPE | 340 | 62.1 (11.5) |
Figure S138. Get High-res Image Gene #83: 'DEL PEAK 34(16Q21) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 3.09e-23 (Fisher's exact test), Q value = 1.5e-20
Table S139. Gene #83: 'DEL PEAK 34(16Q21) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 34(16Q21) MUTATED | 57 | 7 | 65 |
| DEL PEAK 34(16Q21) WILD-TYPE | 302 | 11 | 28 |
Figure S139. Get High-res Image Gene #83: 'DEL PEAK 34(16Q21) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 2.1e-07 (t-test), Q value = 8.2e-05
Table S140. Gene #84: 'DEL PEAK 35(16Q23.1) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 35(16Q23.1) MUTATED | 139 | 67.6 (9.6) |
| DEL PEAK 35(16Q23.1) WILD-TYPE | 330 | 62.1 (11.6) |
Figure S140. Get High-res Image Gene #84: 'DEL PEAK 35(16Q23.1) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.28e-26 (Fisher's exact test), Q value = 6.2e-24
Table S141. Gene #84: 'DEL PEAK 35(16Q23.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 35(16Q23.1) MUTATED | 62 | 6 | 71 |
| DEL PEAK 35(16Q23.1) WILD-TYPE | 297 | 12 | 22 |
Figure S141. Get High-res Image Gene #84: 'DEL PEAK 35(16Q23.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000146 (t-test), Q value = 0.052
Table S142. Gene #85: 'DEL PEAK 36(17P13.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 36(17P13.3) MUTATED | 100 | 67.2 (9.4) |
| DEL PEAK 36(17P13.3) WILD-TYPE | 369 | 62.8 (11.6) |
Figure S142. Get High-res Image Gene #85: 'DEL PEAK 36(17P13.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.62e-20 (Fisher's exact test), Q value = 7.6e-18
Table S143. Gene #85: 'DEL PEAK 36(17P13.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 36(17P13.3) MUTATED | 39 | 8 | 53 |
| DEL PEAK 36(17P13.3) WILD-TYPE | 320 | 10 | 40 |
Figure S143. Get High-res Image Gene #85: 'DEL PEAK 36(17P13.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 8.51e-07 (t-test), Q value = 0.00033
Table S144. Gene #86: 'DEL PEAK 37(17P11.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 37(17P11.2) MUTATED | 107 | 68.1 (9.6) |
| DEL PEAK 37(17P11.2) WILD-TYPE | 362 | 62.5 (11.4) |
Figure S144. Get High-res Image Gene #86: 'DEL PEAK 37(17P11.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 4.43e-27 (Fisher's exact test), Q value = 2.1e-24
Table S145. Gene #86: 'DEL PEAK 37(17P11.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 37(17P11.2) MUTATED | 38 | 8 | 61 |
| DEL PEAK 37(17P11.2) WILD-TYPE | 321 | 10 | 32 |
Figure S145. Get High-res Image Gene #86: 'DEL PEAK 37(17P11.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 5.01e-06 (t-test), Q value = 0.0019
Table S146. Gene #87: 'DEL PEAK 38(17P11.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 38(17P11.2) MUTATED | 100 | 67.9 (9.5) |
| DEL PEAK 38(17P11.2) WILD-TYPE | 369 | 62.6 (11.5) |
Figure S146. Get High-res Image Gene #87: 'DEL PEAK 38(17P11.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.04e-19 (Fisher's exact test), Q value = 4.8e-17
Table S147. Gene #87: 'DEL PEAK 38(17P11.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 38(17P11.2) MUTATED | 40 | 7 | 53 |
| DEL PEAK 38(17P11.2) WILD-TYPE | 319 | 11 | 40 |
Figure S147. Get High-res Image Gene #87: 'DEL PEAK 38(17P11.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 7.05e-06 (t-test), Q value = 0.0027
Table S148. Gene #88: 'DEL PEAK 39(17Q11.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 39(17Q11.2) MUTATED | 86 | 68.3 (9.7) |
| DEL PEAK 39(17Q11.2) WILD-TYPE | 383 | 62.7 (11.4) |
Figure S148. Get High-res Image Gene #88: 'DEL PEAK 39(17Q11.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 2.11e-11 (Fisher's exact test), Q value = 9e-09
Table S149. Gene #88: 'DEL PEAK 39(17Q11.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 39(17Q11.2) MUTATED | 40 | 5 | 41 |
| DEL PEAK 39(17Q11.2) WILD-TYPE | 319 | 13 | 52 |
Figure S149. Get High-res Image Gene #88: 'DEL PEAK 39(17Q11.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 2.47e-05 (t-test), Q value = 0.0091
Table S150. Gene #89: 'DEL PEAK 40(17Q21.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 40(17Q21.2) MUTATED | 91 | 67.9 (9.9) |
| DEL PEAK 40(17Q21.2) WILD-TYPE | 378 | 62.8 (11.4) |
Figure S150. Get High-res Image Gene #89: 'DEL PEAK 40(17Q21.2) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 6.67e-15 (Fisher's exact test), Q value = 2.9e-12
Table S151. Gene #89: 'DEL PEAK 40(17Q21.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 40(17Q21.2) MUTATED | 39 | 6 | 46 |
| DEL PEAK 40(17Q21.2) WILD-TYPE | 320 | 12 | 47 |
Figure S151. Get High-res Image Gene #89: 'DEL PEAK 40(17Q21.2) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.02e-16 (Fisher's exact test), Q value = 4.6e-14
Table S152. Gene #90: 'DEL PEAK 41(18Q23) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 41(18Q23) MUTATED | 31 | 5 | 45 |
| DEL PEAK 41(18Q23) WILD-TYPE | 328 | 13 | 48 |
Figure S152. Get High-res Image Gene #90: 'DEL PEAK 41(18Q23) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 3.7e-05 (logrank test), Q value = 0.014
Table S153. Gene #91: 'DEL PEAK 42(19P13.3) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
| nPatients | nDeath | Duration Range (Median), Month | |
|---|---|---|---|
| ALL | 467 | 56 | 0.0 - 191.8 (20.9) |
| DEL PEAK 42(19P13.3) MUTATED | 130 | 27 | 0.0 - 125.4 (17.3) |
| DEL PEAK 42(19P13.3) WILD-TYPE | 337 | 29 | 0.1 - 191.8 (23.3) |
Figure S153. Get High-res Image Gene #91: 'DEL PEAK 42(19P13.3) MUTATION STATUS' versus Clinical Feature #1: 'Time to Death'
P value = 7.8e-12 (t-test), Q value = 3.4e-09
Table S154. Gene #91: 'DEL PEAK 42(19P13.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 42(19P13.3) MUTATED | 131 | 68.9 (8.8) |
| DEL PEAK 42(19P13.3) WILD-TYPE | 338 | 61.8 (11.5) |
Figure S154. Get High-res Image Gene #91: 'DEL PEAK 42(19P13.3) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.91e-54 (Fisher's exact test), Q value = 9.4e-52
Table S155. Gene #91: 'DEL PEAK 42(19P13.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 42(19P13.3) MUTATED | 37 | 8 | 86 |
| DEL PEAK 42(19P13.3) WILD-TYPE | 322 | 10 | 7 |
Figure S155. Get High-res Image Gene #91: 'DEL PEAK 42(19P13.3) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.99e-08 (Fisher's exact test), Q value = 8e-06
Table S156. Gene #92: 'DEL PEAK 43(19P12) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 43(19P12) MUTATED | 16 | 4 | 23 |
| DEL PEAK 43(19P12) WILD-TYPE | 343 | 14 | 70 |
Figure S156. Get High-res Image Gene #92: 'DEL PEAK 43(19P12) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 3.29e-17 (Fisher's exact test), Q value = 1.5e-14
Table S157. Gene #93: 'DEL PEAK 44(19Q13.43) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 44(19Q13.43) MUTATED | 14 | 4 | 36 |
| DEL PEAK 44(19Q13.43) WILD-TYPE | 345 | 14 | 57 |
Figure S157. Get High-res Image Gene #93: 'DEL PEAK 44(19Q13.43) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.29e-07 (Fisher's exact test), Q value = 5.1e-05
Table S158. Gene #95: 'DEL PEAK 46(22Q12.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 46(22Q12.1) MUTATED | 39 | 7 | 31 |
| DEL PEAK 46(22Q12.1) WILD-TYPE | 320 | 11 | 62 |
Figure S158. Get High-res Image Gene #95: 'DEL PEAK 46(22Q12.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 8.3e-09 (t-test), Q value = 3.4e-06
Table S159. Gene #96: 'DEL PEAK 47(22Q13.31) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 47(22Q13.31) MUTATED | 112 | 68.7 (9.5) |
| DEL PEAK 47(22Q13.31) WILD-TYPE | 357 | 62.2 (11.4) |
Figure S159. Get High-res Image Gene #96: 'DEL PEAK 47(22Q13.31) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 4.94e-22 (Fisher's exact test), Q value = 2.3e-19
Table S160. Gene #96: 'DEL PEAK 47(22Q13.31) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 47(22Q13.31) MUTATED | 46 | 7 | 59 |
| DEL PEAK 47(22Q13.31) WILD-TYPE | 313 | 11 | 34 |
Figure S160. Get High-res Image Gene #96: 'DEL PEAK 47(22Q13.31) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 1.05e-07 (t-test), Q value = 4.1e-05
Table S161. Gene #97: 'DEL PEAK 48(22Q13.32) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 48(22Q13.32) MUTATED | 117 | 68.4 (10.1) |
| DEL PEAK 48(22Q13.32) WILD-TYPE | 352 | 62.2 (11.3) |
Figure S161. Get High-res Image Gene #97: 'DEL PEAK 48(22Q13.32) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 3.46e-22 (Fisher's exact test), Q value = 1.6e-19
Table S162. Gene #97: 'DEL PEAK 48(22Q13.32) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 48(22Q13.32) MUTATED | 49 | 8 | 60 |
| DEL PEAK 48(22Q13.32) WILD-TYPE | 310 | 10 | 33 |
Figure S162. Get High-res Image Gene #97: 'DEL PEAK 48(22Q13.32) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
P value = 0.000163 (t-test), Q value = 0.058
Table S163. Gene #98: 'DEL PEAK 49(XP21.1) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
| nPatients | Mean (Std.Dev) | |
|---|---|---|
| ALL | 469 | 63.8 (11.3) |
| DEL PEAK 49(XP21.1) MUTATED | 74 | 67.8 (9.4) |
| DEL PEAK 49(XP21.1) WILD-TYPE | 395 | 63.0 (11.5) |
Figure S163. Get High-res Image Gene #98: 'DEL PEAK 49(XP21.1) MUTATION STATUS' versus Clinical Feature #2: 'AGE'
P value = 1.99e-15 (Fisher's exact test), Q value = 8.8e-13
Table S164. Gene #98: 'DEL PEAK 49(XP21.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
| nPatients | ENDOMETRIOID ENDOMETRIAL ADENOCARCINOMA | MIXED SEROUS AND ENDOMETRIOID | SEROUS ENDOMETRIAL ADENOCARCINOMA |
|---|---|---|---|
| ALL | 359 | 18 | 93 |
| DEL PEAK 49(XP21.1) MUTATED | 29 | 2 | 43 |
| DEL PEAK 49(XP21.1) WILD-TYPE | 330 | 16 | 50 |
Figure S164. Get High-res Image Gene #98: 'DEL PEAK 49(XP21.1) MUTATION STATUS' versus Clinical Feature #3: 'HISTOLOGICAL.TYPE'
-
Copy number data file = transformed.cor.cli.txt
-
Clinical data file = UCEC-TP.clin.merged.picked.txt
-
Number of patients = 470
-
Number of significantly focal cnvs = 98
-
Number of selected clinical features = 5
-
Exclude genes that fewer than K tumors have mutations, K = 3
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For continuous numerical clinical features, two-tailed Student's t test with unequal variance (Lehmann and Romano 2005) was applied to compare the clinical values between tumors with and without gene mutations using 't.test' function in R
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.