Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.143 0.26 -9999.0 0.0 -0.667 28.0 28.0 IHH -0.113 0.211 -9999.0 0.0 -0.496 39.0 39.0 SHH Np/Cholesterol/GAS1 -0.213 0.248 -9999.0 0.0 -0.504 67.0 67.0 LRPAP1 0.011 0.033 -9999.0 0.0 -0.439 1.0 1.0 dorsoventral neural tube patterning 0.211 0.246 0.499 67.0 -9999.0 0.0 67.0 SMO/beta Arrestin2 -0.128 0.223 -9999.0 0.0 -0.627 19.0 19.0 SMO -0.143 0.235 -9999.0 0.0 -0.605 26.0 26.0 AKT1 -0.044 0.097 -9999.0 0.0 -0.32 4.0 4.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.022 0.13 -9999.0 0.0 -0.481 13.0 13.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.141 0.23 -9999.0 0.0 -0.593 26.0 26.0 STIL -0.157 0.209 -9999.0 0.0 -0.5 33.0 33.0 DHH N/PTCH2 -0.052 0.152 -9999.0 0.0 -0.475 20.0 20.0 DHH N/PTCH1 -0.095 0.176 -9999.0 0.0 -0.467 22.0 22.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.021 0.146 -9999.0 0.0 -0.65 9.0 9.0 PTHLH -0.217 0.401 -9999.0 0.0 -1.053 28.0 28.0 determination of left/right symmetry -0.141 0.23 -9999.0 0.0 -0.593 26.0 26.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.214 0.394 -9999.0 0.0 -1.034 28.0 28.0 IHH N/Hhip -0.14 0.23 -9999.0 0.0 -0.47 50.0 50.0 DHH N/Hhip -0.102 0.197 -9999.0 0.0 -0.43 43.0 43.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.141 0.23 -9999.0 0.0 -0.593 26.0 26.0 pancreas development -0.1 0.232 -9999.0 0.0 -0.551 36.0 36.0 HHAT 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.168 0.3 -9999.0 0.0 -0.645 50.0 50.0 somite specification -0.141 0.23 -9999.0 0.0 -0.593 26.0 26.0 SHH Np/Cholesterol/PTCH1 -0.172 0.219 -9999.0 0.0 -0.508 40.0 40.0 SHH Np/Cholesterol/PTCH2 -0.134 0.189 -9999.0 0.0 -0.432 44.0 44.0 SHH Np/Cholesterol/Megalin -0.151 0.193 -9999.0 0.0 -0.459 39.0 39.0 SHH -0.14 0.224 -9999.0 0.0 -0.426 65.0 65.0 catabolic process -0.093 0.172 -9999.0 0.0 -0.49 18.0 18.0 SMO/Vitamin D3 -0.186 0.241 -9999.0 0.0 -0.563 37.0 37.0 SHH Np/Cholesterol/Hhip -0.174 0.226 -9999.0 0.0 -0.484 54.0 54.0 LRP2 -0.062 0.185 -9999.0 0.0 -0.501 26.0 26.0 receptor-mediated endocytosis -0.208 0.225 -9999.0 0.0 -0.56 41.0 41.0 SHH Np/Cholesterol/BOC -0.13 0.179 -9999.0 0.0 -0.433 37.0 37.0 SHH Np/Cholesterol/CDO -0.144 0.202 -9999.0 0.0 -0.453 46.0 46.0 mesenchymal cell differentiation 0.172 0.224 0.48 54.0 -9999.0 0.0 54.0 mol:Vitamin D3 -0.171 0.22 -9999.0 0.0 -0.509 40.0 40.0 IHH N/PTCH2 -0.084 0.175 -9999.0 0.0 -0.433 29.0 29.0 CDON -0.045 0.189 -9999.0 0.0 -0.642 16.0 16.0 IHH N/PTCH1 -0.094 0.174 -9999.0 0.0 -0.495 18.0 18.0 Megalin/LRPAP1 -0.052 0.13 -9999.0 0.0 -0.352 27.0 27.0 PTCH2 -0.026 0.158 -9999.0 0.0 -0.636 11.0 11.0 SHH Np/Cholesterol -0.117 0.172 -9999.0 0.0 -0.333 65.0 65.0 PTCH1 -0.094 0.173 -9999.0 0.0 -0.491 18.0 18.0 HHIP -0.1 0.232 -9999.0 0.0 -0.552 36.0 36.0