Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.017 0.067 -9999.0 0.0 -0.296 8.0 8.0 epithelial cell differentiation -0.017 0.078 -9999.0 0.0 -0.382 8.0 8.0 CYFIP2 -0.013 0.133 -9999.0 0.0 -0.672 7.0 7.0 ENAH 0.04 0.094 -9999.0 0.0 -0.463 3.0 3.0 EGFR -0.055 0.197 -9999.0 0.0 -0.602 20.0 20.0 EPHA2 -0.019 0.148 -9999.0 0.0 -0.71 8.0 8.0 MYO6 0.016 0.099 -9999.0 0.0 -0.403 9.0 9.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.016 0.083 -9999.0 0.0 -0.453 6.0 6.0 AQP5 -0.025 0.076 -9999.0 0.0 -0.445 2.0 2.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.021 0.08 -9999.0 0.0 -0.355 8.0 8.0 regulation of calcium-dependent cell-cell adhesion -0.02 0.138 -9999.0 0.0 -0.405 16.0 16.0 EGF -0.062 0.176 -9999.0 0.0 -0.468 28.0 28.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.107 0.219 -9999.0 0.0 -0.595 28.0 28.0 cortical microtubule organization -0.017 0.078 -9999.0 0.0 -0.382 8.0 8.0 GO:0000145 0.02 0.077 -9999.0 0.0 -0.339 8.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.017 0.079 -9999.0 0.0 -0.386 8.0 8.0 MLLT4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.029 0.113 -9999.0 0.0 -0.702 3.0 3.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.022 0.102 -9999.0 0.0 -0.452 9.0 9.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.031 0.08 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.005 0.075 -9999.0 0.0 -0.71 2.0 2.0 ZYX 0.019 0.087 -9999.0 0.0 -0.361 9.0 9.0 ARF6/GTP -0.021 0.094 -9999.0 0.0 -0.415 9.0 9.0 CDH1 -0.019 0.148 -9999.0 0.0 -0.71 8.0 8.0 EGFR/EGFR/EGF/EGF -0.075 0.144 -9999.0 0.0 -0.422 20.0 20.0 RhoA/GDP -0.016 0.073 -9999.0 0.0 -0.356 8.0 8.0 actin cytoskeleton organization 0.021 0.098 -9999.0 0.0 -0.683 1.0 1.0 IGF-1R heterotetramer -0.003 0.106 -9999.0 0.0 -0.709 4.0 4.0 GIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.003 0.106 -9999.0 0.0 -0.71 4.0 4.0 IGF1 -0.129 0.256 -9999.0 0.0 -0.559 45.0 45.0 DIAPH1 -0.023 0.113 -9999.0 0.0 -0.635 6.0 6.0 Wnt receptor signaling pathway 0.017 0.078 0.382 8.0 -9999.0 0.0 8.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.029 0.113 -9999.0 0.0 -0.702 3.0 3.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.021 0.1 -9999.0 0.0 -0.709 1.0 1.0 EFNA1 0.005 0.075 -9999.0 0.0 -0.71 2.0 2.0 LPP 0.028 0.078 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.034 0.133 -9999.0 0.0 -0.506 9.0 9.0 SEC6/SEC8 -0.017 0.071 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.021 0.14 -9999.0 0.0 -0.412 16.0 16.0 HGF/MET -0.07 0.136 -9999.0 0.0 -0.374 22.0 22.0 HGF -0.112 0.248 -9999.0 0.0 -0.571 39.0 39.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.017 0.068 -9999.0 0.0 -0.298 8.0 8.0 actin cable formation 0.056 0.086 -9999.0 0.0 -0.355 4.0 4.0 KIAA1543 -0.004 0.187 -9999.0 0.0 -0.844 7.0 7.0 KIFC3 0.016 0.091 -9999.0 0.0 -0.361 10.0 10.0 NCK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.021 0.082 -9999.0 0.0 -0.36 8.0 8.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.017 0.078 -9999.0 0.0 -0.382 8.0 8.0 EXOC4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.021 0.082 -9999.0 0.0 -0.36 8.0 8.0 PIP5K1C 0.021 0.082 -9999.0 0.0 -0.36 8.0 8.0 LIMA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.033 0.11 -9999.0 0.0 -0.578 3.0 3.0 adherens junction assembly 0.008 0.179 -9999.0 0.0 -0.724 8.0 8.0 IGF-1R heterotetramer/IGF1 -0.085 0.147 -9999.0 0.0 -0.588 4.0 4.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.006 0.055 -9999.0 0.0 -0.531 2.0 2.0 MET 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 0.004 0.144 -9999.0 0.0 -0.534 11.0 11.0 mol:GTP -0.022 0.101 -9999.0 0.0 -0.449 9.0 9.0 establishment of epithelial cell apical/basal polarity 0.043 0.081 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.017 0.067 -9999.0 0.0 -0.296 8.0 8.0 regulation of cell-cell adhesion 0.021 0.098 -9999.0 0.0 -0.683 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.017 0.068 -9999.0 0.0 -0.298 8.0 8.0