Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.021 0.199 -9999.0 0.0 -0.549 20.0 20.0 IHH 0.028 0.105 0.214 1.0 -0.355 7.0 8.0 SHH Np/Cholesterol/GAS1 -0.073 0.151 -9999.0 0.0 -0.291 54.0 54.0 LRPAP1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.073 0.149 0.289 54.0 -9999.0 0.0 54.0 SMO/beta Arrestin2 -0.044 0.188 -9999.0 0.0 -0.533 14.0 14.0 SMO -0.06 0.192 -9999.0 0.0 -0.53 16.0 16.0 AKT1 -0.021 0.13 -9999.0 0.0 -0.447 8.0 8.0 ARRB2 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.028 0.046 -9999.0 0.0 -0.484 1.0 1.0 ADRBK1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.058 0.189 -9999.0 0.0 -0.521 16.0 16.0 STIL -0.051 0.132 -9999.0 0.0 -0.351 13.0 13.0 DHH N/PTCH2 0.009 0.106 -9999.0 0.0 -0.352 14.0 14.0 DHH N/PTCH1 -0.002 0.129 -9999.0 0.0 -0.279 28.0 28.0 PIK3CA 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.003 0.1 -9999.0 0.0 -0.484 7.0 7.0 PTHLH -0.065 0.316 -9999.0 0.0 -0.892 21.0 21.0 determination of left/right symmetry -0.058 0.189 -9999.0 0.0 -0.521 16.0 16.0 PIK3R1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.064 0.312 -9999.0 0.0 -0.88 21.0 21.0 IHH N/Hhip 0.012 0.138 0.191 5.0 -0.388 16.0 21.0 DHH N/Hhip 0.001 0.131 -9999.0 0.0 -0.366 19.0 19.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.058 0.189 -9999.0 0.0 -0.521 16.0 16.0 pancreas development -0.005 0.139 -9999.0 0.0 -0.484 13.0 13.0 HHAT 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.035 0.013 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.046 0.187 -9999.0 0.0 -0.484 27.0 27.0 somite specification -0.058 0.189 -9999.0 0.0 -0.521 16.0 16.0 SHH Np/Cholesterol/PTCH1 -0.043 0.144 -9999.0 0.0 -0.283 36.0 36.0 SHH Np/Cholesterol/PTCH2 -0.036 0.127 -9999.0 0.0 -0.279 37.0 37.0 SHH Np/Cholesterol/Megalin -0.032 0.131 -9999.0 0.0 -0.285 36.0 36.0 SHH -0.053 0.143 0.259 1.0 -0.352 32.0 33.0 catabolic process -0.003 0.126 -9999.0 0.0 -0.306 25.0 25.0 SMO/Vitamin D3 -0.063 0.173 -9999.0 0.0 -0.446 18.0 18.0 SHH Np/Cholesterol/Hhip -0.043 0.144 -9999.0 0.0 -0.296 40.0 40.0 LRP2 0.014 0.099 -9999.0 0.0 -0.484 6.0 6.0 receptor-mediated endocytosis -0.069 0.173 -9999.0 0.0 -0.476 17.0 17.0 SHH Np/Cholesterol/BOC -0.023 0.115 -9999.0 0.0 -0.272 30.0 30.0 SHH Np/Cholesterol/CDO -0.04 0.127 -9999.0 0.0 -0.278 38.0 38.0 mesenchymal cell differentiation 0.043 0.143 0.294 40.0 -9999.0 0.0 40.0 mol:Vitamin D3 -0.039 0.149 0.401 1.0 -0.291 32.0 33.0 IHH N/PTCH2 0.019 0.106 -9999.0 0.0 -0.354 11.0 11.0 CDON 0.005 0.107 -9999.0 0.0 -0.484 8.0 8.0 IHH N/PTCH1 0.012 0.135 -9999.0 0.0 -0.308 25.0 25.0 Megalin/LRPAP1 0.031 0.07 -9999.0 0.0 -0.352 5.0 5.0 PTCH2 0.007 0.1 -9999.0 0.0 -0.484 7.0 7.0 SHH Np/Cholesterol -0.037 0.109 -9999.0 0.0 -0.269 32.0 32.0 PTCH1 -0.003 0.126 -9999.0 0.0 -0.307 25.0 25.0 HHIP -0.005 0.139 -9999.0 0.0 -0.484 13.0 13.0