Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.008 0.056 -9999.0 0.0 -0.233 8.0 8.0 epithelial cell differentiation 0.037 0.066 -9999.0 0.0 -0.257 8.0 8.0 CYFIP2 0.013 0.085 -9999.0 0.0 -0.484 5.0 5.0 ENAH 0.004 0.104 0.282 12.0 -0.356 3.0 15.0 EGFR -0.009 0.128 -9999.0 0.0 -0.484 12.0 12.0 EPHA2 0.004 0.106 -9999.0 0.0 -0.484 8.0 8.0 MYO6 -0.012 0.083 0.188 13.0 -0.275 9.0 22.0 CTNNB1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.039 0.06 -9999.0 0.0 -0.297 5.0 5.0 AQP5 0.01 0.067 0.266 2.0 -9999.0 0.0 2.0 CTNND1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.011 0.069 0.173 12.0 -0.246 8.0 20.0 regulation of calcium-dependent cell-cell adhesion -0.015 0.097 0.193 12.0 -0.26 16.0 28.0 EGF 0.029 0.078 -9999.0 0.0 -0.484 3.0 3.0 NCKAP1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.077 0.199 -9999.0 0.0 -0.502 27.0 27.0 cortical microtubule organization 0.037 0.066 -9999.0 0.0 -0.257 8.0 8.0 GO:0000145 -0.012 0.065 0.16 12.0 -0.235 8.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.042 0.069 -9999.0 0.0 -0.259 8.0 8.0 MLLT4 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.036 0.075 -9999.0 0.0 -0.301 11.0 11.0 ARF6 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.043 0.075 -9999.0 0.0 -0.316 6.0 6.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.004 0.065 0.344 1.0 -0.228 7.0 8.0 PVRL2 0.02 0.054 -9999.0 0.0 -0.484 2.0 2.0 ZYX -0.01 0.075 0.188 13.0 -0.248 8.0 21.0 ARF6/GTP 0.048 0.074 -9999.0 0.0 -0.297 6.0 6.0 CDH1 0.003 0.106 -9999.0 0.0 -0.484 8.0 8.0 EGFR/EGFR/EGF/EGF 0.012 0.106 -9999.0 0.0 -0.282 18.0 18.0 RhoA/GDP 0.037 0.065 -9999.0 0.0 -0.247 8.0 8.0 actin cytoskeleton organization -0.014 0.078 0.176 12.0 -0.268 9.0 21.0 IGF-1R heterotetramer 0.018 0.066 -9999.0 0.0 -0.484 3.0 3.0 GIT1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.018 0.066 -9999.0 0.0 -0.484 3.0 3.0 IGF1 -0.017 0.17 -9999.0 0.0 -0.484 20.0 20.0 DIAPH1 -0.003 0.173 -9999.0 0.0 -0.592 10.0 10.0 Wnt receptor signaling pathway -0.037 0.066 0.257 8.0 -9999.0 0.0 8.0 RHOA 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.036 0.075 -9999.0 0.0 -0.31 10.0 10.0 CTNNA1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.014 0.079 0.335 1.0 -0.274 9.0 10.0 EFNA1 0.019 0.054 -9999.0 0.0 -0.484 2.0 2.0 LPP -0.014 0.068 0.183 10.0 -0.241 8.0 18.0 Ephrin A1/EPHA2 0.017 0.099 -9999.0 0.0 -0.317 12.0 12.0 SEC6/SEC8 -0.026 0.047 -9999.0 0.0 -0.238 7.0 7.0 MGAT3 -0.015 0.098 0.195 12.0 -0.264 16.0 28.0 HGF/MET 0.008 0.102 -9999.0 0.0 -0.243 24.0 24.0 HGF -0.016 0.16 -9999.0 0.0 -0.484 18.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.008 0.057 -9999.0 0.0 -0.235 8.0 8.0 actin cable formation 0.026 0.108 0.295 13.0 -0.283 4.0 17.0 KIAA1543 -0.02 0.099 0.175 13.0 -0.337 11.0 24.0 KIFC3 -0.015 0.076 0.19 11.0 -0.248 10.0 21.0 NCK1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.01 0.075 0.188 13.0 -0.249 8.0 21.0 NCK1/GIT1 0.036 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.037 0.066 -9999.0 0.0 -0.257 8.0 8.0 EXOC4 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.007 0.07 0.188 13.0 -0.249 6.0 19.0 PIP5K1C -0.012 0.07 0.175 12.0 -0.249 8.0 20.0 LIMA1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.007 0.117 0.303 12.0 -0.422 3.0 15.0 adherens junction assembly -0.023 0.113 0.267 1.0 -0.41 8.0 9.0 IGF-1R heterotetramer/IGF1 -0.001 0.116 -9999.0 0.0 -0.251 30.0 30.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.032 0.042 -9999.0 0.0 -0.352 2.0 2.0 MET 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.02 0.105 0.188 13.0 -0.353 11.0 24.0 mol:GTP 0.041 0.074 -9999.0 0.0 -0.314 6.0 6.0 establishment of epithelial cell apical/basal polarity 0.022 0.114 0.355 8.0 -9999.0 0.0 8.0 cortical actin cytoskeleton stabilization 0.008 0.056 -9999.0 0.0 -0.233 8.0 8.0 regulation of cell-cell adhesion -0.014 0.078 0.176 12.0 -0.268 9.0 21.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.008 0.057 -9999.0 0.0 -0.235 8.0 8.0