Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
IL23-mediated signaling events	29.0	1786.0	60.0	-0.439	0.027	1000.0	-1000.0	-0.072	-1000.0
Syndecan-1-mediated signaling events	26.0	892.0	34.0	-0.13	0.027	1000.0	-1000.0	-0.029	-1000.0
IL4-mediated signaling events	23.0	2176.0	91.0	-0.438	0.383	1000.0	-1000.0	-0.084	-1000.0
Signaling mediated by p38-alpha and p38-beta	23.0	1020.0	44.0	-0.088	0.027	1000.0	-1000.0	-0.023	-1000.0
TCR signaling in naïve CD8+ T cells	23.0	2224.0	93.0	-0.12	0.037	1000.0	-1000.0	-0.044	-1000.0
TCGA08_retinoblastoma	23.0	191.0	8.0	-0.054	0.064	1000.0	-1000.0	-0.003	-1000.0
IL12-mediated signaling events	20.0	1788.0	87.0	-0.252	0.029	1000.0	-1000.0	-0.058	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	20.0	1416.0	68.0	-0.233	0.11	1000.0	-1000.0	-0.05	-1000.0
Signaling events mediated by the Hedgehog family	18.0	938.0	52.0	-0.073	0.073	1000.0	-1000.0	-0.026	-1000.0
Glucocorticoid receptor regulatory network	18.0	2081.0	114.0	-0.442	0.217	1000.0	-1000.0	-0.043	-1000.0
Endothelins	18.0	1745.0	96.0	-0.086	0.034	1000.0	-1000.0	-0.048	-1000.0
Syndecan-4-mediated signaling events	17.0	1182.0	67.0	-0.133	0.041	1000.0	-1000.0	-0.03	-1000.0
amb2 Integrin signaling	16.0	1345.0	82.0	-0.106	0.034	1000.0	-1000.0	-0.025	-1000.0
LPA receptor mediated events	16.0	1725.0	102.0	-0.107	0.029	1000.0	-1000.0	-0.051	-1000.0
Thromboxane A2 receptor signaling	15.0	1671.0	105.0	-0.094	0.033	1000.0	-1000.0	-0.042	-1000.0
Osteopontin-mediated events	14.0	562.0	38.0	-0.103	0.027	1000.0	-1000.0	-0.039	-1000.0
Noncanonical Wnt signaling pathway	14.0	379.0	26.0	-0.069	0.027	1000.0	-1000.0	-0.034	-1000.0
HIF-1-alpha transcription factor network	14.0	1080.0	76.0	-0.123	0.036	1000.0	-1000.0	-0.028	-1000.0
Fc-epsilon receptor I signaling in mast cells	14.0	1415.0	97.0	-0.094	0.038	1000.0	-1000.0	-0.046	-1000.0
S1P5 pathway	14.0	239.0	17.0	-0.042	0.03	1000.0	-1000.0	-0.005	-1000.0
IL27-mediated signaling events	14.0	732.0	51.0	-0.191	0.068	1000.0	-1000.0	-0.04	-1000.0
Wnt signaling	14.0	104.0	7.0	-0.062	0.016	1000.0	-1000.0	-0.011	-1000.0
Caspase cascade in apoptosis	13.0	971.0	74.0	-0.094	0.07	1000.0	-1000.0	-0.032	-1000.0
p75(NTR)-mediated signaling	13.0	1650.0	125.0	-0.075	0.059	1000.0	-1000.0	-0.055	-1000.0
Calcium signaling in the CD4+ TCR pathway	13.0	431.0	31.0	-0.127	0.026	1000.0	-1000.0	-0.045	-1000.0
BCR signaling pathway	13.0	1320.0	99.0	-0.103	0.031	1000.0	-1000.0	-0.048	-1000.0
BMP receptor signaling	12.0	1046.0	81.0	-0.112	0.051	1000.0	-1000.0	-0.041	-1000.0
Reelin signaling pathway	12.0	682.0	56.0	-0.053	0.059	1000.0	-1000.0	-0.028	-1000.0
IGF1 pathway	12.0	732.0	57.0	-0.043	0.046	1000.0	-1000.0	-0.03	-1000.0
EPHB forward signaling	11.0	1007.0	85.0	-0.059	0.052	1000.0	-1000.0	-0.054	-1000.0
Class IB PI3K non-lipid kinase events	11.0	33.0	3.0	-0.005	-1000.0	1000.0	-1000.0	-0.01	-1000.0
S1P4 pathway	11.0	299.0	25.0	-0.042	0.038	1000.0	-1000.0	-0.016	-1000.0
Nectin adhesion pathway	10.0	637.0	63.0	-0.066	0.046	1000.0	-1000.0	-0.04	-1000.0
IL1-mediated signaling events	10.0	645.0	62.0	-0.066	0.057	1000.0	-1000.0	-0.03	-1000.0
Signaling events regulated by Ret tyrosine kinase	10.0	828.0	82.0	-0.043	0.027	1000.0	-1000.0	-0.045	-1000.0
Ephrin B reverse signaling	10.0	514.0	48.0	-0.036	0.033	1000.0	-1000.0	-0.027	-1000.0
Glypican 2 network	10.0	41.0	4.0	0.005	0.014	1000.0	-1000.0	0.005	-1000.0
Nongenotropic Androgen signaling	10.0	536.0	52.0	-0.058	0.043	1000.0	-1000.0	-0.026	-1000.0
IL6-mediated signaling events	10.0	803.0	75.0	-0.067	0.058	1000.0	-1000.0	-0.035	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	10.0	750.0	74.0	-0.077	0.048	1000.0	-1000.0	-0.057	-1000.0
ErbB2/ErbB3 signaling events	9.0	607.0	65.0	-0.036	0.037	1000.0	-1000.0	-0.043	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	9.0	310.0	34.0	-0.015	0.04	1000.0	-1000.0	-0.025	-1000.0
JNK signaling in the CD4+ TCR pathway	9.0	164.0	17.0	-0.055	0.041	1000.0	-1000.0	-0.033	-1000.0
S1P1 pathway	9.0	332.0	36.0	-0.073	0.025	1000.0	-1000.0	-0.034	-1000.0
Integrins in angiogenesis	9.0	817.0	84.0	-0.088	0.05	1000.0	-1000.0	-0.036	-1000.0
Visual signal transduction: Rods	9.0	506.0	52.0	-0.09	0.035	1000.0	-1000.0	-0.029	-1000.0
FOXM1 transcription factor network	9.0	462.0	51.0	-0.168	0.039	1000.0	-1000.0	-0.097	-1000.0
Coregulation of Androgen receptor activity	8.0	672.0	76.0	-0.248	0.045	1000.0	-1000.0	-0.018	-1000.0
Sphingosine 1-phosphate (S1P) pathway	8.0	236.0	28.0	-0.042	0.036	1000.0	-1000.0	-0.012	-1000.0
a4b1 and a4b7 Integrin signaling	8.0	41.0	5.0	0.002	0.017	1000.0	-1000.0	0.009	-1000.0
FOXA2 and FOXA3 transcription factor networks	8.0	370.0	46.0	-0.17	0.039	1000.0	-1000.0	-0.078	-1000.0
ceramide signaling pathway	8.0	435.0	49.0	-0.013	0.04	1000.0	-1000.0	-0.028	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	8.0	1033.0	120.0	-0.153	0.11	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	8.0	646.0	78.0	-0.041	0.036	1000.0	-1000.0	-0.037	-1000.0
Syndecan-2-mediated signaling events	7.0	543.0	69.0	-0.045	0.044	1000.0	-1000.0	-0.036	-1000.0
Arf6 signaling events	7.0	491.0	62.0	-0.016	0.043	1000.0	-1000.0	-0.025	-1000.0
Glypican 1 network	7.0	381.0	48.0	-0.058	0.041	1000.0	-1000.0	-0.027	-1000.0
IFN-gamma pathway	7.0	512.0	68.0	-0.046	0.04	1000.0	-1000.0	-0.051	-1000.0
HIF-2-alpha transcription factor network	7.0	333.0	43.0	-0.034	0.04	1000.0	-1000.0	-0.034	-1000.0
FAS signaling pathway (CD95)	7.0	351.0	47.0	-0.15	0.038	1000.0	-1000.0	-0.024	-1000.0
IL2 signaling events mediated by PI3K	7.0	406.0	58.0	-0.06	0.041	1000.0	-1000.0	-0.04	-1000.0
Plasma membrane estrogen receptor signaling	7.0	638.0	86.0	-0.045	0.05	1000.0	-1000.0	-0.034	-1000.0
S1P3 pathway	7.0	324.0	42.0	-0.017	0.04	1000.0	-1000.0	-0.02	-1000.0
Regulation of Androgen receptor activity	7.0	541.0	70.0	-0.313	0.039	1000.0	-1000.0	-0.046	-1000.0
Ras signaling in the CD4+ TCR pathway	7.0	123.0	17.0	-0.022	0.047	1000.0	-1000.0	-0.03	-1000.0
Visual signal transduction: Cones	6.0	255.0	38.0	-0.016	0.036	1000.0	-1000.0	-0.01	-1000.0
Ephrin A  reverse signaling	6.0	42.0	7.0	-0.012	0.02	1000.0	-1000.0	-0.004	-1000.0
Signaling events mediated by PTP1B	6.0	479.0	76.0	-0.043	0.041	1000.0	-1000.0	-0.029	-1000.0
Ceramide signaling pathway	6.0	502.0	76.0	-0.017	0.066	1000.0	-1000.0	-0.021	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	6.0	347.0	52.0	-0.063	0.067	1000.0	-1000.0	-0.032	-1000.0
Signaling mediated by p38-gamma and p38-delta	6.0	95.0	15.0	-0.021	0.024	1000.0	-1000.0	-0.028	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	6.0	289.0	45.0	-0.01	0.048	1000.0	-1000.0	-0.028	-1000.0
E-cadherin signaling in the nascent adherens junction	6.0	499.0	76.0	-0.058	0.046	1000.0	-1000.0	-0.049	-1000.0
IL2 signaling events mediated by STAT5	6.0	135.0	22.0	-0.093	0.029	1000.0	-1000.0	-0.024	-1000.0
EGFR-dependent Endothelin signaling events	6.0	139.0	21.0	-0.027	0.045	1000.0	-1000.0	-0.037	-1000.0
Angiopoietin receptor Tie2-mediated signaling	6.0	543.0	88.0	-0.045	0.034	1000.0	-1000.0	-0.055	-1000.0
LPA4-mediated signaling events	5.0	71.0	12.0	-0.029	0.01	1000.0	-1000.0	-0.022	-1000.0
Regulation of nuclear SMAD2/3 signaling	5.0	800.0	136.0	-0.341	0.051	1000.0	-1000.0	-0.028	-1000.0
ErbB4 signaling events	5.0	379.0	69.0	-0.055	0.035	1000.0	-1000.0	-0.033	-1000.0
BARD1 signaling events	5.0	329.0	57.0	-0.021	0.046	1000.0	-1000.0	-0.03	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	5.0	270.0	54.0	-0.038	0.038	1000.0	-1000.0	-0.03	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	5.0	457.0	85.0	-0.021	0.037	1000.0	-1000.0	-0.045	-1000.0
Hedgehog signaling events mediated by Gli proteins	5.0	379.0	65.0	-0.055	0.064	1000.0	-1000.0	-0.034	-1000.0
Presenilin action in Notch and Wnt signaling	5.0	306.0	61.0	-0.088	0.069	1000.0	-1000.0	-0.04	-1000.0
TCGA08_p53	5.0	40.0	7.0	-0.006	0.027	1000.0	-1000.0	-0.005	-1000.0
Canonical Wnt signaling pathway	5.0	290.0	51.0	-0.052	0.063	1000.0	-1000.0	-0.044	-1000.0
Effects of Botulinum toxin	5.0	143.0	26.0	-0.032	0.048	1000.0	-1000.0	-0.006	-1000.0
PDGFR-beta signaling pathway	5.0	548.0	97.0	-0.052	0.055	1000.0	-1000.0	-0.045	-1000.0
E-cadherin signaling in keratinocytes	5.0	239.0	43.0	-0.021	0.032	1000.0	-1000.0	-0.029	-1000.0
E-cadherin signaling events	5.0	28.0	5.0	0.003	0.027	1000.0	-1000.0	0.006	-1000.0
Cellular roles of Anthrax toxin	4.0	176.0	39.0	-0.035	0.028	1000.0	-1000.0	-0.02	-1000.0
PDGFR-alpha signaling pathway	4.0	213.0	44.0	-0.033	0.048	1000.0	-1000.0	-0.041	-1000.0
mTOR signaling pathway	4.0	225.0	53.0	-0.045	0.029	1000.0	-1000.0	-0.03	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	4.0	178.0	37.0	-0.024	0.044	1000.0	-1000.0	-0.024	-1000.0
Paxillin-dependent events mediated by a4b1	4.0	144.0	36.0	-0.032	0.045	1000.0	-1000.0	-0.027	-1000.0
Syndecan-3-mediated signaling events	4.0	140.0	35.0	-0.036	0.059	1000.0	-1000.0	-0.015	-1000.0
Class I PI3K signaling events	4.0	328.0	73.0	-0.054	0.046	1000.0	-1000.0	-0.037	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	4.0	133.0	33.0	-0.033	0.054	1000.0	-1000.0	-0.025	-1000.0
Rapid glucocorticoid signaling	4.0	93.0	20.0	-0.051	0.035	1000.0	-1000.0	-0.003	-1000.0
Aurora B signaling	4.0	312.0	67.0	-0.171	0.061	1000.0	-1000.0	-0.035	-1000.0
EPO signaling pathway	3.0	187.0	55.0	0.0	0.068	1000.0	-1000.0	-0.029	-1000.0
PLK1 signaling events	3.0	258.0	85.0	-0.012	0.049	1000.0	-1000.0	-0.022	-1000.0
TRAIL signaling pathway	3.0	160.0	48.0	-0.021	0.041	1000.0	-1000.0	-0.022	-1000.0
Regulation of p38-alpha and p38-beta	3.0	187.0	54.0	-0.045	0.056	1000.0	-1000.0	-0.045	-1000.0
Regulation of Telomerase	3.0	354.0	102.0	-0.102	0.057	1000.0	-1000.0	-0.06	-1000.0
Insulin Pathway	3.0	242.0	74.0	-0.031	0.065	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by HDAC Class III	2.0	94.0	40.0	-0.049	0.049	1000.0	-1000.0	-0.027	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	233.0	83.0	-0.027	0.046	1000.0	-1000.0	-0.027	-1000.0
Retinoic acid receptors-mediated signaling	2.0	134.0	58.0	-0.002	0.059	1000.0	-1000.0	-0.024	-1000.0
Atypical NF-kappaB pathway	2.0	82.0	31.0	-0.0	0.035	1000.0	-1000.0	-0.008	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	297.0	125.0	-0.014	0.063	1000.0	-1000.0	-0.027	-1000.0
TCGA08_rtk_signaling	2.0	73.0	26.0	-0.031	0.057	1000.0	-1000.0	-0.008	-1000.0
VEGFR1 specific signals	2.0	136.0	56.0	-0.029	0.055	1000.0	-1000.0	-0.038	-1000.0
Canonical NF-kappaB pathway	1.0	63.0	39.0	-0.007	0.056	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by HDAC Class II	1.0	103.0	75.0	-0.027	0.069	1000.0	-1000.0	-0.024	-1000.0
Aurora A signaling	1.0	69.0	60.0	-0.0	0.049	1000.0	-1000.0	-0.021	-1000.0
Arf6 downstream pathway	1.0	78.0	43.0	-0.039	0.045	1000.0	-1000.0	-0.025	-1000.0
Aurora C signaling	1.0	8.0	7.0	-0.0	0.039	1000.0	-1000.0	-0.011	-1000.0
Insulin-mediated glucose transport	1.0	43.0	32.0	-0.008	0.046	1000.0	-1000.0	-0.025	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	83.0	68.0	-0.04	0.06	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by HDAC Class I	1.0	167.0	104.0	-0.049	0.064	1000.0	-1000.0	-0.027	-1000.0
FoxO family signaling	1.0	118.0	64.0	-0.056	0.059	1000.0	-1000.0	-0.034	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	1.0	37.0	27.0	-0.011	0.056	1000.0	-1000.0	-0.03	-1000.0
Arf6 trafficking events	1.0	137.0	71.0	-0.033	0.048	1000.0	-1000.0	-0.029	-1000.0
Signaling events mediated by PRL	1.0	58.0	34.0	-0.044	0.039	1000.0	-1000.0	-0.029	-1000.0
p38 MAPK signaling pathway	1.0	82.0	44.0	-0.007	0.052	1000.0	-1000.0	-0.016	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	21.0	23.0	0.001	0.047	1000.0	-1000.0	-0.033	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.011	0.026	1000.0	-1000.0	-0.007	-1000.0
Circadian rhythm pathway	0.0	18.0	22.0	-0.009	0.039	1000.0	-1000.0	-0.032	-1000.0
Arf1 pathway	0.0	26.0	54.0	-0.001	0.044	1000.0	-1000.0	-0.016	-1000.0
Alternative NF-kappaB pathway	0.0	2.0	13.0	0.0	0.068	1000.0	-1000.0	0.0	-1000.0
Total	1021	63986	7203	-9.0084040527	-993.669727313	131000	-131000	-4.04689573333	-131000