This pipeline computes the correlation between significantly recurrent gene mutations and molecular subtypes.
Testing the association between mutation status of 89 genes and 12 molecular subtypes across 771 patients, 57 significant findings detected with P value < 0.05 and Q value < 0.25.
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PIK3CA mutation correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'CN_CNMF', 'METHLYATION_CNMF', 'RPPA_CNMF', 'RPPA_CHIERARCHICAL', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', 'MIRSEQ_MATURE_CNMF', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
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AKT1 mutation correlated to 'METHLYATION_CNMF' and 'MRNASEQ_CNMF'.
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GATA3 mutation correlated to 'MRNA_CHIERARCHICAL', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', 'MIRSEQ_MATURE_CNMF', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
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TP53 mutation correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'CN_CNMF', 'METHLYATION_CNMF', 'RPPA_CNMF', 'RPPA_CHIERARCHICAL', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', 'MIRSEQ_MATURE_CNMF', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
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CDH1 mutation correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'CN_CNMF', 'RPPA_CNMF', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', 'MIRSEQ_MATURE_CNMF', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
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MAP3K1 mutation correlated to 'MRNA_CNMF', 'MRNA_CHIERARCHICAL', 'CN_CNMF', 'RPPA_CNMF', 'RPPA_CHIERARCHICAL', 'MRNASEQ_CNMF', 'MRNASEQ_CHIERARCHICAL', 'MIRSEQ_CNMF', 'MIRSEQ_CHIERARCHICAL', 'MIRSEQ_MATURE_CNMF', and 'MIRSEQ_MATURE_CHIERARCHICAL'.
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CBFB mutation correlated to 'MIRSEQ_CHIERARCHICAL'.
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TTN mutation correlated to 'CN_CNMF' and 'RPPA_CNMF'.
Clinical Features |
MRNA CNMF |
MRNA CHIERARCHICAL |
CN CNMF |
METHLYATION CNMF |
RPPA CNMF |
RPPA CHIERARCHICAL |
MRNASEQ CNMF |
MRNASEQ CHIERARCHICAL |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
MIRSEQ MATURE CNMF |
MIRSEQ MATURE CHIERARCHICAL |
||
nMutated (%) | nWild-Type | Chi-square test | Fisher's exact test | Chi-square test | Chi-square test | Fisher's exact test | Fisher's exact test | Chi-square test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | |
PIK3CA | 261 (34%) | 510 |
8.9e-15 (7.81e-12) |
3.88e-10 (3.38e-07) |
1.68e-13 (1.47e-10) |
7.31e-11 (6.39e-08) |
1.64e-05 (0.014) |
1.06e-06 (0.000919) |
3.83e-29 (3.39e-26) |
6.84e-11 (5.99e-08) |
2.32e-10 (2.02e-07) |
3.16e-18 (2.78e-15) |
0.000184 (0.155) |
4.13e-07 (0.000358) |
TP53 | 257 (33%) | 514 |
7.08e-37 (6.28e-34) |
2.43e-33 (2.15e-30) |
8.75e-53 (7.8e-50) |
6.95e-21 (6.11e-18) |
1.87e-27 (1.66e-24) |
1.1e-23 (9.71e-21) |
3.31e-56 (2.95e-53) |
1.14e-48 (1.01e-45) |
2.65e-38 (2.35e-35) |
4e-43 (3.56e-40) |
2.88e-27 (2.54e-24) |
1.07e-27 (9.5e-25) |
MAP3K1 | 57 (7%) | 714 |
4.33e-06 (0.00371) |
4.38e-05 (0.0373) |
2.08e-05 (0.0177) |
0.0185 (1.00) |
0.000204 (0.171) |
1.99e-06 (0.00171) |
0.000118 (0.0999) |
1.99e-05 (0.017) |
4.24e-07 (0.000366) |
1.73e-05 (0.0148) |
2.48e-05 (0.0212) |
0.000284 (0.237) |
CDH1 | 55 (7%) | 716 |
1.67e-07 (0.000145) |
8.2e-05 (0.0695) |
2.2e-08 (1.91e-05) |
0.00103 (0.852) |
0.000255 (0.214) |
0.000579 (0.48) |
3.37e-06 (0.0029) |
5.15e-08 (4.47e-05) |
7.7e-11 (6.72e-08) |
7.42e-12 (6.5e-09) |
6.54e-05 (0.0555) |
8.56e-05 (0.0724) |
GATA3 | 81 (11%) | 690 |
0.000575 (0.477) |
0.000101 (0.0856) |
0.00404 (1.00) |
0.01 (1.00) |
0.00115 (0.949) |
0.000407 (0.34) |
4.65e-05 (0.0396) |
2.75e-09 (2.39e-06) |
3.5e-06 (0.00301) |
1.06e-06 (0.000913) |
1.18e-06 (0.00102) |
0.000102 (0.0857) |
AKT1 | 19 (2%) | 752 |
0.0634 (1.00) |
0.925 (1.00) |
0.00333 (1.00) |
0.000216 (0.181) |
0.162 (1.00) |
0.345 (1.00) |
0.00021 (0.176) |
0.348 (1.00) |
0.0633 (1.00) |
0.0167 (1.00) |
0.216 (1.00) |
0.125 (1.00) |
TTN | 122 (16%) | 649 |
0.122 (1.00) |
0.0385 (1.00) |
0.00017 (0.143) |
0.0329 (1.00) |
6.23e-05 (0.0529) |
0.052 (1.00) |
0.000382 (0.319) |
0.00465 (1.00) |
0.0615 (1.00) |
0.00681 (1.00) |
0.0687 (1.00) |
0.0455 (1.00) |
CBFB | 16 (2%) | 755 |
0.184 (1.00) |
0.648 (1.00) |
0.0245 (1.00) |
0.000863 (0.714) |
0.35 (1.00) |
0.569 (1.00) |
0.000563 (0.468) |
0.124 (1.00) |
0.0327 (1.00) |
6.12e-05 (0.052) |
0.0708 (1.00) |
0.034 (1.00) |
PTEN | 29 (4%) | 742 |
0.226 (1.00) |
0.437 (1.00) |
0.162 (1.00) |
0.389 (1.00) |
0.882 (1.00) |
0.266 (1.00) |
0.177 (1.00) |
0.968 (1.00) |
0.674 (1.00) |
0.691 (1.00) |
0.102 (1.00) |
0.14 (1.00) |
MLL3 | 61 (8%) | 710 |
0.279 (1.00) |
0.922 (1.00) |
0.834 (1.00) |
0.704 (1.00) |
0.702 (1.00) |
0.968 (1.00) |
0.275 (1.00) |
0.922 (1.00) |
0.137 (1.00) |
0.221 (1.00) |
0.604 (1.00) |
0.926 (1.00) |
NUDT11 | 8 (1%) | 763 |
0.702 (1.00) |
0.179 (1.00) |
0.172 (1.00) |
0.897 (1.00) |
0.8 (1.00) |
0.275 (1.00) |
0.701 (1.00) |
0.272 (1.00) |
||||
GIGYF2 | 13 (2%) | 758 |
0.454 (1.00) |
0.685 (1.00) |
0.546 (1.00) |
0.437 (1.00) |
0.871 (1.00) |
1 (1.00) |
0.672 (1.00) |
0.817 (1.00) |
||||
ZNF384 | 14 (2%) | 757 |
0.487 (1.00) |
0.437 (1.00) |
0.51 (1.00) |
0.67 (1.00) |
0.82 (1.00) |
0.396 (1.00) |
0.401 (1.00) |
0.71 (1.00) |
||||
DCP1B | 5 (1%) | 766 |
0.365 (1.00) |
0.126 (1.00) |
0.772 (1.00) |
0.723 (1.00) |
1 (1.00) |
0.527 (1.00) |
0.588 (1.00) |
0.795 (1.00) |
||||
NCOA3 | 29 (4%) | 742 |
0.549 (1.00) |
1 (1.00) |
0.975 (1.00) |
0.505 (1.00) |
1 (1.00) |
1 (1.00) |
0.611 (1.00) |
0.746 (1.00) |
0.496 (1.00) |
0.23 (1.00) |
0.0622 (1.00) |
0.773 (1.00) |
AOAH | 19 (2%) | 752 |
0.426 (1.00) |
0.736 (1.00) |
0.646 (1.00) |
0.175 (1.00) |
0.0861 (1.00) |
0.871 (1.00) |
0.15 (1.00) |
0.721 (1.00) |
||||
RBMX | 13 (2%) | 758 |
0.00151 (1.00) |
0.236 (1.00) |
0.563 (1.00) |
0.183 (1.00) |
0.532 (1.00) |
0.345 (1.00) |
1 (1.00) |
0.5 (1.00) |
||||
RUNX1 | 25 (3%) | 746 |
0.00552 (1.00) |
0.0442 (1.00) |
0.000931 (0.769) |
0.0563 (1.00) |
1 (1.00) |
0.252 (1.00) |
0.0222 (1.00) |
0.58 (1.00) |
0.0666 (1.00) |
0.305 (1.00) |
0.0593 (1.00) |
0.934 (1.00) |
PIK3R1 | 21 (3%) | 750 |
0.172 (1.00) |
0.616 (1.00) |
0.492 (1.00) |
0.709 (1.00) |
0.538 (1.00) |
0.297 (1.00) |
0.12 (1.00) |
0.385 (1.00) |
0.387 (1.00) |
0.871 (1.00) |
0.672 (1.00) |
0.617 (1.00) |
MEF2A | 14 (2%) | 757 |
0.577 (1.00) |
0.377 (1.00) |
0.553 (1.00) |
0.271 (1.00) |
0.0352 (1.00) |
0.0386 (1.00) |
0.0606 (1.00) |
0.21 (1.00) |
||||
NCOR2 | 29 (4%) | 742 |
0.676 (1.00) |
1 (1.00) |
0.112 (1.00) |
0.483 (1.00) |
0.839 (1.00) |
0.69 (1.00) |
0.838 (1.00) |
0.593 (1.00) |
0.767 (1.00) |
0.462 (1.00) |
0.887 (1.00) |
0.777 (1.00) |
NR1H2 | 18 (2%) | 753 |
0.326 (1.00) |
0.267 (1.00) |
0.94 (1.00) |
0.163 (1.00) |
0.064 (1.00) |
0.116 (1.00) |
0.401 (1.00) |
0.246 (1.00) |
0.215 (1.00) |
0.292 (1.00) |
0.78 (1.00) |
0.0385 (1.00) |
MAP3K4 | 18 (2%) | 753 |
0.108 (1.00) |
0.721 (1.00) |
0.768 (1.00) |
0.172 (1.00) |
0.0733 (1.00) |
0.69 (1.00) |
0.223 (1.00) |
0.408 (1.00) |
0.509 (1.00) |
0.413 (1.00) |
0.272 (1.00) |
0.155 (1.00) |
TPRX1 | 7 (1%) | 764 |
0.205 (1.00) |
0.504 (1.00) |
0.958 (1.00) |
1 (1.00) |
0.742 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
||||
ATN1 | 17 (2%) | 754 |
0.0643 (1.00) |
0.0545 (1.00) |
0.0631 (1.00) |
0.896 (1.00) |
0.169 (1.00) |
0.291 (1.00) |
0.0776 (1.00) |
0.855 (1.00) |
0.802 (1.00) |
0.257 (1.00) |
0.321 (1.00) |
0.115 (1.00) |
MAP2K4 | 32 (4%) | 739 |
0.0292 (1.00) |
0.00313 (1.00) |
0.0507 (1.00) |
0.0105 (1.00) |
0.00238 (1.00) |
0.0344 (1.00) |
0.00554 (1.00) |
0.000469 (0.39) |
0.00431 (1.00) |
0.000997 (0.822) |
0.00164 (1.00) |
0.0264 (1.00) |
CTCF | 18 (2%) | 753 |
0.0265 (1.00) |
0.32 (1.00) |
0.00924 (1.00) |
0.0206 (1.00) |
0.0682 (1.00) |
0.369 (1.00) |
0.0045 (1.00) |
0.428 (1.00) |
0.0852 (1.00) |
0.184 (1.00) |
0.831 (1.00) |
0.426 (1.00) |
CCDC144NL | 8 (1%) | 763 |
0.000916 (0.757) |
0.408 (1.00) |
0.664 (1.00) |
0.191 (1.00) |
0.273 (1.00) |
0.478 (1.00) |
0.443 (1.00) |
0.396 (1.00) |
||||
AKD1 | 19 (2%) | 752 |
0.926 (1.00) |
0.437 (1.00) |
0.3 (1.00) |
0.23 (1.00) |
0.467 (1.00) |
0.242 (1.00) |
0.672 (1.00) |
0.0412 (1.00) |
0.129 (1.00) |
0.358 (1.00) |
0.0773 (1.00) |
0.146 (1.00) |
RB1 | 14 (2%) | 757 |
0.523 (1.00) |
0.172 (1.00) |
0.0727 (1.00) |
0.138 (1.00) |
0.483 (1.00) |
0.762 (1.00) |
0.329 (1.00) |
0.297 (1.00) |
0.333 (1.00) |
0.0375 (1.00) |
0.179 (1.00) |
0.0842 (1.00) |
FOXA1 | 15 (2%) | 756 |
0.736 (1.00) |
0.116 (1.00) |
0.135 (1.00) |
0.0262 (1.00) |
1 (1.00) |
0.517 (1.00) |
0.892 (1.00) |
0.157 (1.00) |
0.478 (1.00) |
0.533 (1.00) |
0.532 (1.00) |
0.329 (1.00) |
PHLDA1 | 9 (1%) | 762 |
0.321 (1.00) |
0.275 (1.00) |
0.325 (1.00) |
0.691 (1.00) |
1 (1.00) |
0.28 (1.00) |
0.68 (1.00) |
0.814 (1.00) |
0.32 (1.00) |
0.909 (1.00) |
0.389 (1.00) |
0.382 (1.00) |
VEZF1 | 8 (1%) | 763 |
0.409 (1.00) |
0.548 (1.00) |
0.192 (1.00) |
0.896 (1.00) |
1 (1.00) |
0.818 (1.00) |
1 (1.00) |
0.852 (1.00) |
||||
ZFP36L1 | 10 (1%) | 761 |
0.839 (1.00) |
0.686 (1.00) |
0.028 (1.00) |
0.138 (1.00) |
0.0258 (1.00) |
0.392 (1.00) |
0.84 (1.00) |
0.599 (1.00) |
0.834 (1.00) |
0.417 (1.00) |
0.643 (1.00) |
0.735 (1.00) |
NCOR1 | 31 (4%) | 740 |
0.488 (1.00) |
0.33 (1.00) |
0.354 (1.00) |
0.745 (1.00) |
0.723 (1.00) |
0.726 (1.00) |
0.528 (1.00) |
0.154 (1.00) |
0.446 (1.00) |
0.281 (1.00) |
0.528 (1.00) |
0.747 (1.00) |
AQP7 | 9 (1%) | 762 |
0.638 (1.00) |
0.0682 (1.00) |
0.752 (1.00) |
0.719 (1.00) |
0.721 (1.00) |
0.509 (1.00) |
0.316 (1.00) |
0.657 (1.00) |
0.735 (1.00) |
0.434 (1.00) |
||
TBX3 | 18 (2%) | 753 |
0.612 (1.00) |
0.345 (1.00) |
0.791 (1.00) |
0.18 (1.00) |
0.16 (1.00) |
0.551 (1.00) |
0.395 (1.00) |
0.408 (1.00) |
0.902 (1.00) |
0.91 (1.00) |
0.791 (1.00) |
1 (1.00) |
DSPP | 26 (3%) | 745 |
0.945 (1.00) |
0.416 (1.00) |
0.561 (1.00) |
0.939 (1.00) |
0.0987 (1.00) |
0.387 (1.00) |
0.71 (1.00) |
0.0544 (1.00) |
0.0992 (1.00) |
0.735 (1.00) |
0.261 (1.00) |
0.675 (1.00) |
RPGR | 16 (2%) | 755 |
0.297 (1.00) |
0.205 (1.00) |
0.999 (1.00) |
0.724 (1.00) |
0.616 (1.00) |
0.373 (1.00) |
0.285 (1.00) |
0.269 (1.00) |
0.626 (1.00) |
0.148 (1.00) |
0.649 (1.00) |
0.51 (1.00) |
BCL6B | 8 (1%) | 763 |
0.478 (1.00) |
0.63 (1.00) |
0.249 (1.00) |
0.791 (1.00) |
1 (1.00) |
0.818 (1.00) |
0.735 (1.00) |
0.549 (1.00) |
||||
TBL1XR1 | 9 (1%) | 762 |
0.109 (1.00) |
0.295 (1.00) |
0.156 (1.00) |
0.455 (1.00) |
0.569 (1.00) |
0.0432 (1.00) |
0.152 (1.00) |
0.446 (1.00) |
0.168 (1.00) |
0.864 (1.00) |
0.277 (1.00) |
|
CRIPAK | 13 (2%) | 758 |
0.398 (1.00) |
0.459 (1.00) |
0.453 (1.00) |
0.292 (1.00) |
0.657 (1.00) |
0.55 (1.00) |
0.14 (1.00) |
0.132 (1.00) |
||||
MYB | 11 (1%) | 760 |
0.786 (1.00) |
1 (1.00) |
0.269 (1.00) |
0.355 (1.00) |
1 (1.00) |
0.69 (1.00) |
0.798 (1.00) |
0.574 (1.00) |
0.726 (1.00) |
0.732 (1.00) |
0.547 (1.00) |
1 (1.00) |
GPS2 | 6 (1%) | 765 |
0.00768 (1.00) |
0.0284 (1.00) |
0.128 (1.00) |
0.283 (1.00) |
1 (1.00) |
1 (1.00) |
0.49 (1.00) |
0.559 (1.00) |
0.198 (1.00) |
0.278 (1.00) |
||
PABPC3 | 8 (1%) | 763 |
0.163 (1.00) |
0.801 (1.00) |
0.741 (1.00) |
0.981 (1.00) |
0.68 (1.00) |
0.897 (1.00) |
0.713 (1.00) |
0.909 (1.00) |
1 (1.00) |
1 (1.00) |
||
E2F4 | 4 (1%) | 767 |
0.929 (1.00) |
0.868 (1.00) |
0.687 (1.00) |
0.816 (1.00) |
1 (1.00) |
|||||||
DNAH12 | 12 (2%) | 759 |
0.967 (1.00) |
0.266 (1.00) |
0.849 (1.00) |
0.541 (1.00) |
0.689 (1.00) |
0.69 (1.00) |
0.0799 (1.00) |
0.753 (1.00) |
0.86 (1.00) |
1 (1.00) |
0.791 (1.00) |
0.324 (1.00) |
CDKN1B | 7 (1%) | 764 |
0.358 (1.00) |
0.11 (1.00) |
0.00271 (1.00) |
0.0312 (1.00) |
0.331 (1.00) |
0.392 (1.00) |
0.268 (1.00) |
0.367 (1.00) |
0.041 (1.00) |
0.254 (1.00) |
0.502 (1.00) |
0.559 (1.00) |
HNF1A | 9 (1%) | 762 |
0.194 (1.00) |
0.66 (1.00) |
0.336 (1.00) |
0.107 (1.00) |
0.13 (1.00) |
0.168 (1.00) |
0.63 (1.00) |
0.156 (1.00) |
||||
CCDC66 | 14 (2%) | 757 |
0.367 (1.00) |
0.446 (1.00) |
0.268 (1.00) |
0.865 (1.00) |
1 (1.00) |
0.633 (1.00) |
0.0514 (1.00) |
0.279 (1.00) |
0.516 (1.00) |
0.19 (1.00) |
0.371 (1.00) |
0.0992 (1.00) |
CASP8 | 10 (1%) | 761 |
0.355 (1.00) |
0.197 (1.00) |
0.608 (1.00) |
0.473 (1.00) |
0.402 (1.00) |
1 (1.00) |
0.266 (1.00) |
0.55 (1.00) |
0.0593 (1.00) |
0.033 (1.00) |
0.189 (1.00) |
0.227 (1.00) |
STXBP2 | 10 (1%) | 761 |
0.923 (1.00) |
0.954 (1.00) |
0.807 (1.00) |
0.503 (1.00) |
0.475 (1.00) |
0.505 (1.00) |
0.814 (1.00) |
0.884 (1.00) |
||||
HIST1H3B | 7 (1%) | 764 |
0.383 (1.00) |
1 (1.00) |
0.553 (1.00) |
0.705 (1.00) |
1 (1.00) |
0.827 (1.00) |
0.215 (1.00) |
0.691 (1.00) |
1 (1.00) |
0.796 (1.00) |
0.429 (1.00) |
0.3 (1.00) |
CTU2 | 5 (1%) | 766 |
0.26 (1.00) |
0.534 (1.00) |
0.717 (1.00) |
0.723 (1.00) |
1 (1.00) |
0.0754 (1.00) |
0.466 (1.00) |
0.0304 (1.00) |
||||
SHROOM4 | 12 (2%) | 759 |
0.64 (1.00) |
0.183 (1.00) |
0.107 (1.00) |
0.435 (1.00) |
0.158 (1.00) |
0.314 (1.00) |
0.245 (1.00) |
0.419 (1.00) |
0.74 (1.00) |
0.701 (1.00) |
0.914 (1.00) |
0.486 (1.00) |
HLA-A | 4 (1%) | 767 |
0.816 (1.00) |
0.543 (1.00) |
0.264 (1.00) |
1 (1.00) |
0.827 (1.00) |
0.0116 (1.00) |
0.277 (1.00) |
0.659 (1.00) |
0.214 (1.00) |
|||
SLC25A5 | 3 (0%) | 768 |
0.243 (1.00) |
0.7 (1.00) |
||||||||||
SELPLG | 7 (1%) | 764 |
0.278 (1.00) |
0.1 (1.00) |
0.079 (1.00) |
0.166 (1.00) |
0.31 (1.00) |
0.128 (1.00) |
1 (1.00) |
0.229 (1.00) |
||||
KRTAP9-9 | 6 (1%) | 765 |
0.262 (1.00) |
0.228 (1.00) |
0.138 (1.00) |
1 (1.00) |
0.869 (1.00) |
0.498 (1.00) |
1 (1.00) |
0.0731 (1.00) |
||||
KRTAP4-5 | 4 (1%) | 767 |
0.448 (1.00) |
0.282 (1.00) |
0.146 (1.00) |
0.128 (1.00) |
0.248 (1.00) |
0.691 (1.00) |
0.0949 (1.00) |
1 (1.00) |
||||
SF3B1 | 14 (2%) | 757 |
0.629 (1.00) |
0.0949 (1.00) |
0.378 (1.00) |
0.224 (1.00) |
0.253 (1.00) |
0.00499 (1.00) |
0.254 (1.00) |
0.157 (1.00) |
0.119 (1.00) |
0.475 (1.00) |
0.631 (1.00) |
0.067 (1.00) |
FGFR2 | 7 (1%) | 764 |
0.602 (1.00) |
0.543 (1.00) |
0.848 (1.00) |
0.302 (1.00) |
1 (1.00) |
0.827 (1.00) |
0.249 (1.00) |
0.791 (1.00) |
0.603 (1.00) |
0.494 (1.00) |
0.39 (1.00) |
0.0688 (1.00) |
MUC2 | 22 (3%) | 749 |
0.83 (1.00) |
0.259 (1.00) |
0.328 (1.00) |
0.309 (1.00) |
0.778 (1.00) |
0.881 (1.00) |
0.5 (1.00) |
0.422 (1.00) |
0.598 (1.00) |
0.725 (1.00) |
0.752 (1.00) |
0.287 (1.00) |
MED12 | 20 (3%) | 751 |
0.603 (1.00) |
0.326 (1.00) |
0.352 (1.00) |
0.723 (1.00) |
0.455 (1.00) |
0.803 (1.00) |
0.701 (1.00) |
1 (1.00) |
0.429 (1.00) |
0.803 (1.00) |
0.294 (1.00) |
0.23 (1.00) |
USP36 | 13 (2%) | 758 |
0.668 (1.00) |
0.429 (1.00) |
0.653 (1.00) |
0.388 (1.00) |
0.778 (1.00) |
0.271 (1.00) |
1 (1.00) |
0.823 (1.00) |
0.922 (1.00) |
0.817 (1.00) |
||
DENND4B | 8 (1%) | 763 |
0.209 (1.00) |
0.0346 (1.00) |
0.0773 (1.00) |
0.457 (1.00) |
0.107 (1.00) |
0.147 (1.00) |
0.165 (1.00) |
0.0853 (1.00) |
||||
RAI1 | 7 (1%) | 764 |
0.375 (1.00) |
0.899 (1.00) |
1 (1.00) |
0.782 (1.00) |
0.826 (1.00) |
0.326 (1.00) |
0.52 (1.00) |
0.163 (1.00) |
0.631 (1.00) |
0.83 (1.00) |
||
ODF1 | 5 (1%) | 766 |
0.929 (1.00) |
0.445 (1.00) |
0.689 (1.00) |
0.277 (1.00) |
0.816 (1.00) |
0.356 (1.00) |
0.643 (1.00) |
1 (1.00) |
||||
AXL | 6 (1%) | 765 |
0.377 (1.00) |
0.21 (1.00) |
0.826 (1.00) |
0.0816 (1.00) |
0.714 (1.00) |
1 (1.00) |
0.502 (1.00) |
0.278 (1.00) |
||||
RPL18 | 4 (1%) | 767 |
0.501 (1.00) |
0.192 (1.00) |
0.121 (1.00) |
0.0944 (1.00) |
0.11 (1.00) |
0.0496 (1.00) |
0.274 (1.00) |
0.441 (1.00) |
||||
KRT38 | 4 (1%) | 767 |
0.602 (1.00) |
0.812 (1.00) |
0.238 (1.00) |
0.755 (1.00) |
0.402 (1.00) |
0.633 (1.00) |
0.625 (1.00) |
1 (1.00) |
0.816 (1.00) |
0.0823 (1.00) |
||
ASXL2 | 8 (1%) | 763 |
0.36 (1.00) |
0.214 (1.00) |
0.781 (1.00) |
0.42 (1.00) |
0.812 (1.00) |
0.523 (1.00) |
0.603 (1.00) |
0.441 (1.00) |
0.75 (1.00) |
0.18 (1.00) |
||
TICAM1 | 5 (1%) | 766 |
0.755 (1.00) |
0.873 (1.00) |
0.949 (1.00) |
0.449 (1.00) |
1 (1.00) |
0.527 (1.00) |
0.819 (1.00) |
1 (1.00) |
||||
RBM5 | 12 (2%) | 759 |
0.758 (1.00) |
0.772 (1.00) |
0.75 (1.00) |
0.809 (1.00) |
0.308 (1.00) |
0.207 (1.00) |
0.0514 (1.00) |
0.523 (1.00) |
||||
ASPHD1 | 3 (0%) | 768 |
0.686 (1.00) |
0.876 (1.00) |
0.564 (1.00) |
0.81 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
1 (1.00) |
||||
PPEF1 | 8 (1%) | 763 |
0.853 (1.00) |
1 (1.00) |
0.355 (1.00) |
0.472 (1.00) |
1 (1.00) |
1 (1.00) |
0.432 (1.00) |
0.592 (1.00) |
0.273 (1.00) |
0.384 (1.00) |
0.103 (1.00) |
0.12 (1.00) |
MUC20 | 10 (1%) | 761 |
0.0149 (1.00) |
0.178 (1.00) |
0.00043 (0.358) |
0.0546 (1.00) |
0.36 (1.00) |
0.125 (1.00) |
0.649 (1.00) |
0.14 (1.00) |
||||
TMEM184A | 4 (1%) | 767 |
0.543 (1.00) |
0.00609 (1.00) |
0.958 (1.00) |
0.687 (1.00) |
1 (1.00) |
0.278 (1.00) |
0.00677 (1.00) |
0.00125 (1.00) |
||||
FAM171B | 8 (1%) | 763 |
0.925 (1.00) |
0.291 (1.00) |
0.552 (1.00) |
0.0565 (1.00) |
0.2 (1.00) |
0.00175 (1.00) |
0.603 (1.00) |
0.0374 (1.00) |
0.173 (1.00) |
0.128 (1.00) |
||
PRRX1 | 6 (1%) | 765 |
0.577 (1.00) |
0.522 (1.00) |
0.398 (1.00) |
0.0939 (1.00) |
0.839 (1.00) |
0.392 (1.00) |
0.489 (1.00) |
0.496 (1.00) |
0.293 (1.00) |
0.435 (1.00) |
0.588 (1.00) |
0.68 (1.00) |
ATP13A4 | 9 (1%) | 762 |
0.602 (1.00) |
0.356 (1.00) |
0.134 (1.00) |
0.362 (1.00) |
0.865 (1.00) |
0.335 (1.00) |
0.907 (1.00) |
0.631 (1.00) |
0.443 (1.00) |
0.506 (1.00) |
||
MUC21 | 6 (1%) | 765 |
0.317 (1.00) |
0.429 (1.00) |
0.128 (1.00) |
0.277 (1.00) |
0.649 (1.00) |
0.496 (1.00) |
0.869 (1.00) |
0.242 (1.00) |
1 (1.00) |
0.3 (1.00) |
||
HLA-B | 4 (1%) | 767 |
0.612 (1.00) |
0.7 (1.00) |
0.381 (1.00) |
1 (1.00) |
0.816 (1.00) |
0.356 (1.00) |
1 (1.00) |
1 (1.00) |
||||
RBM23 | 6 (1%) | 765 |
0.667 (1.00) |
0.328 (1.00) |
0.789 (1.00) |
0.0358 (1.00) |
0.351 (1.00) |
0.0872 (1.00) |
0.643 (1.00) |
0.735 (1.00) |
||||
UBC | 8 (1%) | 763 |
0.336 (1.00) |
1 (1.00) |
0.744 (1.00) |
0.309 (1.00) |
0.556 (1.00) |
0.827 (1.00) |
0.215 (1.00) |
1 (1.00) |
0.899 (1.00) |
0.275 (1.00) |
||
SPRED3 | 4 (1%) | 767 |
0.845 (1.00) |
0.751 (1.00) |
0.958 (1.00) |
0.469 (1.00) |
0.536 (1.00) |
0.278 (1.00) |
0.429 (1.00) |
0.3 (1.00) |
||||
KCNN3 | 6 (1%) | 765 |
0.968 (1.00) |
1 (1.00) |
0.0707 (1.00) |
0.311 (1.00) |
0.102 (1.00) |
0.379 (1.00) |
0.351 (1.00) |
0.673 (1.00) |
0.274 (1.00) |
0.18 (1.00) |
||
GNRH2 | 3 (0%) | 768 |
0.247 (1.00) |
0.822 (1.00) |
1 (1.00) |
0.775 (1.00) |
0.801 (1.00) |
|||||||
MED15 | 7 (1%) | 764 |
0.437 (1.00) |
0.124 (1.00) |
0.524 (1.00) |
0.288 (1.00) |
0.235 (1.00) |
0.254 (1.00) |
0.179 (1.00) |
0.229 (1.00) |
P value = 8.9e-15 (Chi-square test), Q value = 7.8e-12
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 | CLUS_8 |
---|---|---|---|---|---|---|---|---|
ALL | 21 | 36 | 118 | 95 | 105 | 74 | 20 | 40 |
PIK3CA MUTATED | 7 | 12 | 24 | 7 | 62 | 25 | 9 | 23 |
PIK3CA WILD-TYPE | 14 | 24 | 94 | 88 | 43 | 49 | 11 | 17 |
P value = 3.88e-10 (Fisher's exact test), Q value = 3.4e-07
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 120 | 125 | 264 |
PIK3CA MUTATED | 61 | 16 | 92 |
PIK3CA WILD-TYPE | 59 | 109 | 172 |
P value = 1.68e-13 (Chi-square test), Q value = 1.5e-10
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 254 | 206 | 60 | 198 | 41 |
PIK3CA MUTATED | 121 | 49 | 37 | 45 | 8 |
PIK3CA WILD-TYPE | 133 | 157 | 23 | 153 | 33 |
P value = 7.31e-11 (Chi-square test), Q value = 6.4e-08
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 |
---|---|---|---|---|---|---|
ALL | 75 | 115 | 74 | 113 | 27 | 61 |
PIK3CA MUTATED | 5 | 65 | 30 | 29 | 10 | 19 |
PIK3CA WILD-TYPE | 70 | 50 | 44 | 84 | 17 | 42 |
P value = 1.64e-05 (Fisher's exact test), Q value = 0.014
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 144 | 133 | 119 |
PIK3CA MUTATED | 26 | 53 | 49 |
PIK3CA WILD-TYPE | 118 | 80 | 70 |
P value = 1.06e-06 (Fisher's exact test), Q value = 0.00092
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 157 | 114 | 125 |
PIK3CA MUTATED | 55 | 53 | 20 |
PIK3CA WILD-TYPE | 102 | 61 | 105 |
P value = 3.83e-29 (Chi-square test), Q value = 3.4e-26
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 131 | 96 | 172 | 131 | 193 | 23 | 14 |
PIK3CA MUTATED | 6 | 47 | 101 | 55 | 30 | 10 | 9 |
PIK3CA WILD-TYPE | 125 | 49 | 71 | 76 | 163 | 13 | 5 |
P value = 6.84e-11 (Fisher's exact test), Q value = 6e-08
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 196 | 188 | 376 |
PIK3CA MUTATED | 91 | 29 | 138 |
PIK3CA WILD-TYPE | 105 | 159 | 238 |
P value = 2.32e-10 (Fisher's exact test), Q value = 2e-07
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 396 | 205 |
PIK3CA MUTATED | 73 | 151 | 35 |
PIK3CA WILD-TYPE | 80 | 245 | 170 |
P value = 3.16e-18 (Fisher's exact test), Q value = 2.8e-15
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 170 | 250 | 334 |
PIK3CA MUTATED | 23 | 135 | 101 |
PIK3CA WILD-TYPE | 147 | 115 | 233 |
P value = 0.000184 (Fisher's exact test), Q value = 0.15
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 242 | 78 | 126 |
PIK3CA MUTATED | 96 | 32 | 25 |
PIK3CA WILD-TYPE | 146 | 46 | 101 |
P value = 4.13e-07 (Fisher's exact test), Q value = 0.00036
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 46 | 277 | 123 |
PIK3CA MUTATED | 26 | 106 | 21 |
PIK3CA WILD-TYPE | 20 | 171 | 102 |
P value = 0.000216 (Chi-square test), Q value = 0.18
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 |
---|---|---|---|---|---|---|
ALL | 75 | 115 | 74 | 113 | 27 | 61 |
AKT1 MUTATED | 0 | 11 | 2 | 0 | 0 | 1 |
AKT1 WILD-TYPE | 75 | 104 | 72 | 113 | 27 | 60 |
P value = 0.00021 (Chi-square test), Q value = 0.18
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 131 | 96 | 172 | 131 | 193 | 23 | 14 |
AKT1 MUTATED | 0 | 3 | 13 | 2 | 1 | 0 | 0 |
AKT1 WILD-TYPE | 131 | 93 | 159 | 129 | 192 | 23 | 14 |
P value = 0.000101 (Fisher's exact test), Q value = 0.086
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 120 | 125 | 264 |
GATA3 MUTATED | 15 | 2 | 37 |
GATA3 WILD-TYPE | 105 | 123 | 227 |
P value = 4.65e-05 (Chi-square test), Q value = 0.04
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 131 | 96 | 172 | 131 | 193 | 23 | 14 |
GATA3 MUTATED | 1 | 14 | 25 | 7 | 31 | 2 | 0 |
GATA3 WILD-TYPE | 130 | 82 | 147 | 124 | 162 | 21 | 14 |
P value = 2.75e-09 (Fisher's exact test), Q value = 2.4e-06
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 196 | 188 | 376 |
GATA3 MUTATED | 22 | 1 | 57 |
GATA3 WILD-TYPE | 174 | 187 | 319 |
P value = 3.5e-06 (Fisher's exact test), Q value = 0.003
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 396 | 205 |
GATA3 MUTATED | 17 | 57 | 5 |
GATA3 WILD-TYPE | 136 | 339 | 200 |
P value = 1.06e-06 (Fisher's exact test), Q value = 0.00091
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 170 | 250 | 334 |
GATA3 MUTATED | 2 | 31 | 46 |
GATA3 WILD-TYPE | 168 | 219 | 288 |
P value = 1.18e-06 (Fisher's exact test), Q value = 0.001
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 242 | 78 | 126 |
GATA3 MUTATED | 45 | 9 | 2 |
GATA3 WILD-TYPE | 197 | 69 | 124 |
P value = 0.000102 (Fisher's exact test), Q value = 0.086
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 46 | 277 | 123 |
GATA3 MUTATED | 4 | 48 | 4 |
GATA3 WILD-TYPE | 42 | 229 | 119 |
P value = 7.08e-37 (Chi-square test), Q value = 6.3e-34
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 | CLUS_8 |
---|---|---|---|---|---|---|---|---|
ALL | 21 | 36 | 118 | 95 | 105 | 74 | 20 | 40 |
TP53 MUTATED | 6 | 6 | 23 | 77 | 6 | 50 | 10 | 6 |
TP53 WILD-TYPE | 15 | 30 | 95 | 18 | 99 | 24 | 10 | 34 |
P value = 2.43e-33 (Fisher's exact test), Q value = 2.1e-30
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 120 | 125 | 264 |
TP53 MUTATED | 16 | 101 | 67 |
TP53 WILD-TYPE | 104 | 24 | 197 |
P value = 8.75e-53 (Chi-square test), Q value = 7.8e-50
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 254 | 206 | 60 | 198 | 41 |
TP53 MUTATED | 29 | 51 | 7 | 154 | 14 |
TP53 WILD-TYPE | 225 | 155 | 53 | 44 | 27 |
P value = 6.95e-21 (Chi-square test), Q value = 6.1e-18
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 |
---|---|---|---|---|---|---|
ALL | 75 | 115 | 74 | 113 | 27 | 61 |
TP53 MUTATED | 58 | 11 | 27 | 29 | 4 | 19 |
TP53 WILD-TYPE | 17 | 104 | 47 | 84 | 23 | 42 |
P value = 1.87e-27 (Fisher's exact test), Q value = 1.7e-24
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 144 | 133 | 119 |
TP53 MUTATED | 102 | 12 | 38 |
TP53 WILD-TYPE | 42 | 121 | 81 |
P value = 1.1e-23 (Fisher's exact test), Q value = 9.7e-21
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 157 | 114 | 125 |
TP53 MUTATED | 35 | 23 | 94 |
TP53 WILD-TYPE | 122 | 91 | 31 |
P value = 3.31e-56 (Chi-square test), Q value = 3e-53
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 131 | 96 | 172 | 131 | 193 | 23 | 14 |
TP53 MUTATED | 103 | 12 | 11 | 82 | 33 | 5 | 8 |
TP53 WILD-TYPE | 28 | 84 | 161 | 49 | 160 | 18 | 6 |
P value = 1.14e-48 (Fisher's exact test), Q value = 1e-45
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 196 | 188 | 376 |
TP53 MUTATED | 26 | 146 | 82 |
TP53 WILD-TYPE | 170 | 42 | 294 |
P value = 2.65e-38 (Fisher's exact test), Q value = 2.4e-35
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 396 | 205 |
TP53 MUTATED | 16 | 92 | 142 |
TP53 WILD-TYPE | 137 | 304 | 63 |
P value = 4e-43 (Fisher's exact test), Q value = 3.6e-40
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 170 | 250 | 334 |
TP53 MUTATED | 128 | 28 | 94 |
TP53 WILD-TYPE | 42 | 222 | 240 |
P value = 2.88e-27 (Fisher's exact test), Q value = 2.5e-24
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 242 | 78 | 126 |
TP53 MUTATED | 45 | 9 | 90 |
TP53 WILD-TYPE | 197 | 69 | 36 |
P value = 1.07e-27 (Fisher's exact test), Q value = 9.5e-25
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 46 | 277 | 123 |
TP53 MUTATED | 11 | 44 | 89 |
TP53 WILD-TYPE | 35 | 233 | 34 |
P value = 1.67e-07 (Chi-square test), Q value = 0.00014
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 | CLUS_8 |
---|---|---|---|---|---|---|---|---|
ALL | 21 | 36 | 118 | 95 | 105 | 74 | 20 | 40 |
CDH1 MUTATED | 0 | 5 | 1 | 0 | 12 | 4 | 1 | 10 |
CDH1 WILD-TYPE | 21 | 31 | 117 | 95 | 93 | 70 | 19 | 30 |
P value = 8.2e-05 (Fisher's exact test), Q value = 0.069
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 120 | 125 | 264 |
CDH1 MUTATED | 18 | 2 | 13 |
CDH1 WILD-TYPE | 102 | 123 | 251 |
P value = 2.2e-08 (Chi-square test), Q value = 1.9e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 254 | 206 | 60 | 198 | 41 |
CDH1 MUTATED | 27 | 9 | 14 | 2 | 3 |
CDH1 WILD-TYPE | 227 | 197 | 46 | 196 | 38 |
P value = 0.000255 (Fisher's exact test), Q value = 0.21
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 144 | 133 | 119 |
CDH1 MUTATED | 3 | 4 | 16 |
CDH1 WILD-TYPE | 141 | 129 | 103 |
P value = 3.37e-06 (Chi-square test), Q value = 0.0029
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 131 | 96 | 172 | 131 | 193 | 23 | 14 |
CDH1 MUTATED | 0 | 17 | 18 | 7 | 8 | 4 | 1 |
CDH1 WILD-TYPE | 131 | 79 | 154 | 124 | 185 | 19 | 13 |
P value = 5.15e-08 (Fisher's exact test), Q value = 4.5e-05
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 196 | 188 | 376 |
CDH1 MUTATED | 31 | 2 | 22 |
CDH1 WILD-TYPE | 165 | 186 | 354 |
P value = 7.7e-11 (Fisher's exact test), Q value = 6.7e-08
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 396 | 205 |
CDH1 MUTATED | 29 | 23 | 1 |
CDH1 WILD-TYPE | 124 | 373 | 204 |
P value = 7.42e-12 (Fisher's exact test), Q value = 6.5e-09
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 170 | 250 | 334 |
CDH1 MUTATED | 0 | 40 | 13 |
CDH1 WILD-TYPE | 170 | 210 | 321 |
P value = 6.54e-05 (Fisher's exact test), Q value = 0.055
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 242 | 78 | 126 |
CDH1 MUTATED | 14 | 14 | 2 |
CDH1 WILD-TYPE | 228 | 64 | 124 |
P value = 8.56e-05 (Fisher's exact test), Q value = 0.072
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 46 | 277 | 123 |
CDH1 MUTATED | 6 | 24 | 0 |
CDH1 WILD-TYPE | 40 | 253 | 123 |
P value = 4.33e-06 (Chi-square test), Q value = 0.0037
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 | CLUS_8 |
---|---|---|---|---|---|---|---|---|
ALL | 21 | 36 | 118 | 95 | 105 | 74 | 20 | 40 |
MAP3K1 MUTATED | 6 | 1 | 11 | 0 | 16 | 1 | 0 | 4 |
MAP3K1 WILD-TYPE | 15 | 35 | 107 | 95 | 89 | 73 | 20 | 36 |
P value = 4.38e-05 (Fisher's exact test), Q value = 0.037
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 120 | 125 | 264 |
MAP3K1 MUTATED | 13 | 0 | 26 |
MAP3K1 WILD-TYPE | 107 | 125 | 238 |
P value = 2.08e-05 (Chi-square test), Q value = 0.018
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 254 | 206 | 60 | 198 | 41 |
MAP3K1 MUTATED | 34 | 8 | 7 | 4 | 4 |
MAP3K1 WILD-TYPE | 220 | 198 | 53 | 194 | 37 |
P value = 0.000204 (Fisher's exact test), Q value = 0.17
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 144 | 133 | 119 |
MAP3K1 MUTATED | 3 | 20 | 13 |
MAP3K1 WILD-TYPE | 141 | 113 | 106 |
P value = 1.99e-06 (Fisher's exact test), Q value = 0.0017
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 157 | 114 | 125 |
MAP3K1 MUTATED | 20 | 16 | 0 |
MAP3K1 WILD-TYPE | 137 | 98 | 125 |
P value = 0.000118 (Chi-square test), Q value = 0.1
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 | CLUS_6 | CLUS_7 |
---|---|---|---|---|---|---|---|
ALL | 131 | 96 | 172 | 131 | 193 | 23 | 14 |
MAP3K1 MUTATED | 0 | 11 | 23 | 4 | 18 | 1 | 0 |
MAP3K1 WILD-TYPE | 131 | 85 | 149 | 127 | 175 | 22 | 14 |
P value = 1.99e-05 (Fisher's exact test), Q value = 0.017
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 196 | 188 | 376 |
MAP3K1 MUTATED | 14 | 2 | 41 |
MAP3K1 WILD-TYPE | 182 | 186 | 335 |
P value = 4.24e-07 (Fisher's exact test), Q value = 0.00037
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 153 | 396 | 205 |
MAP3K1 MUTATED | 19 | 37 | 1 |
MAP3K1 WILD-TYPE | 134 | 359 | 204 |
P value = 1.73e-05 (Fisher's exact test), Q value = 0.015
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 170 | 250 | 334 |
MAP3K1 MUTATED | 1 | 27 | 29 |
MAP3K1 WILD-TYPE | 169 | 223 | 305 |
P value = 2.48e-05 (Fisher's exact test), Q value = 0.021
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 242 | 78 | 126 |
MAP3K1 MUTATED | 23 | 10 | 0 |
MAP3K1 WILD-TYPE | 219 | 68 | 126 |
P value = 0.000284 (Fisher's exact test), Q value = 0.24
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 46 | 277 | 123 |
MAP3K1 MUTATED | 7 | 25 | 1 |
MAP3K1 WILD-TYPE | 39 | 252 | 122 |
P value = 6.12e-05 (Fisher's exact test), Q value = 0.052
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 170 | 250 | 334 |
CBFB MUTATED | 0 | 13 | 2 |
CBFB WILD-TYPE | 170 | 237 | 332 |
P value = 0.00017 (Chi-square test), Q value = 0.14
nPatients | CLUS_1 | CLUS_2 | CLUS_3 | CLUS_4 | CLUS_5 |
---|---|---|---|---|---|
ALL | 254 | 206 | 60 | 198 | 41 |
TTN MUTATED | 26 | 33 | 4 | 49 | 5 |
TTN WILD-TYPE | 228 | 173 | 56 | 149 | 36 |
P value = 6.23e-05 (Fisher's exact test), Q value = 0.053
nPatients | CLUS_1 | CLUS_2 | CLUS_3 |
---|---|---|---|
ALL | 144 | 133 | 119 |
TTN MUTATED | 38 | 10 | 15 |
TTN WILD-TYPE | 106 | 123 | 104 |
-
Mutation data file = BRCA-TP.mutsig.cluster.txt
-
Molecular subtypes file = BRCA-TP.transferedmergedcluster.txt
-
Number of patients = 771
-
Number of significantly mutated genes = 89
-
Number of Molecular subtypes = 12
-
Exclude genes that fewer than K tumors have mutations, K = 3
For multi-class clinical features (nominal or ordinal), Chi-square tests (Greenwood and Nikulin 1996) were used to estimate the P values using the 'chisq.test' function in R
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.