rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(3), CD34(2), CD3E(2), CD3G(2), CD4(4), CD58(1), CD8A(2), IL6(2), KITLG(3) 7120299 21 21 21 3 0 7 5 4 5 0 0.122 0.0232 1.000 2 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CCNE1(1), CDK2(1), CUL1(2), E2F1(4), FBXW7(6), TFDP1(2) 7497996 16 16 15 1 5 3 2 3 3 0 0.0509 0.0451 1.000 3 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(5), CBS(2), CTH(3), MUT(3) 5387362 13 13 13 0 2 3 2 2 4 0 0.0276 0.0517 1.000 4 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(2), CD28(1), CD3E(2), CD3G(2), CD4(4) 3744423 11 11 11 2 1 4 2 1 3 0 0.312 0.0972 1.000 5 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(2), CD3G(2) 1346070 4 4 4 0 0 3 0 1 0 0 0.208 0.122 1.000 6 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1), IFNG(2), IL12A(1), IL12B(1), IL18(1), IL2(1) 3530673 7 7 7 1 1 0 1 4 1 0 0.554 0.136 1.000 7 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(2), RAB11A(2), RAB1A(2), RAB27A(1), RAB3A(2), RAB6A(1) 4901601 10 10 10 1 0 4 3 0 3 0 0.192 0.139 1.000 8 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 11 APAF1(3), BAK1(2), BAX(2), BCL10(1), BCL2L11(4), BID(4), CASP9(1), CES1(2) 8480554 19 19 18 2 4 5 4 2 4 0 0.126 0.178 1.000 9 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(3), CREM(2), FHL5(2), FSHR(4), GNAS(5), XPO1(4) 10143105 20 20 19 2 4 4 4 5 3 0 0.105 0.192 1.000 10 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(4), ALDOB(2), ALDOC(1), TPI1(2) 4361469 9 9 9 0 0 4 3 1 1 0 0.0405 0.227 1.000 11 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(5), ATM(18), BRCA1(12), CHEK2(3), JUN(3), MAPK8(2), MDM2(2), MRE11A(2), NFKB1(4), NFKBIA(1), RAD50(2), RAD51(2), RBBP8(4), RELA(1), TP73(1) 31833859 62 57 62 5 7 10 15 9 21 0 0.00463 0.241 1.000 12 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CDO1(1), CSAD(2), GAD1(2), GAD2(3), GGT1(4) 6301403 14 14 13 2 2 4 4 1 3 0 0.151 0.270 1.000 13 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(3), ATM(18), BAX(2), CCND1(1), CCNE1(1), CDK2(1), CDK4(1), E2F1(4), MDM2(2), TIMP3(1) 17423711 34 33 33 4 6 6 5 6 11 0 0.0592 0.284 1.000 14 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(1), GNAQ(1), ITPKA(1), ITPKB(7) 6140747 11 11 11 0 1 1 4 3 2 0 0.0596 0.293 1.000 15 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 3 CD28(1), CD4(4) 1746671 5 5 5 2 1 1 2 0 1 0 0.714 0.294 1.000 16 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 10 CCNE1(1), CDK2(1), CUL1(2), E2F1(4), NEDD8(1), SKP2(1), TFDP1(2) 7319484 12 12 11 1 4 1 4 1 2 0 0.146 0.317 1.000 17 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(2), CD2(3), CD3E(2), CD3G(2), CD4(4), CXCR3(5), IFNG(2), IL12A(1), IL12B(1), IL12RB1(4), IL12RB2(1), JAK2(5), STAT4(6), TYK2(5) 16758186 43 39 43 7 5 8 9 8 13 0 0.101 0.334 1.000 18 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 8 CCNA1(1), CCNE1(1), CDK2(1), CUL1(2), E2F1(4), SKP2(1), TFDP1(2) 7729534 12 12 11 1 4 1 3 1 3 0 0.163 0.356 1.000 19 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(6), FBL(2), GPT(3), LDHC(2), MAPK14(2), NCL(3) 10176986 18 18 18 2 6 5 4 2 1 0 0.0539 0.381 1.000 20 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(2) 1932077 3 3 3 1 1 0 0 0 2 0 0.731 0.404 1.000 21 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 9 B3GALT1(1), B3GALT2(1), B3GALT5(2), FUT2(2), FUT3(3), ST3GAL3(3), ST3GAL4(1) 7394854 13 13 12 2 4 4 3 0 2 0 0.0869 0.430 1.000 22 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 6 FUT2(2), FUT3(3), FUT5(2), FUT6(2), ST3GAL3(3) 4630960 12 12 11 3 4 1 4 0 3 0 0.237 0.433 1.000 23 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 825736 1 1 1 2 0 0 0 0 1 0 0.984 0.438 1.000 24 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP5(2), ACPP(5), ACPT(2), ENPP1(5), ENPP3(2), FLAD1(1), RFK(1), TYR(6) 11030458 24 24 23 4 3 4 11 3 3 0 0.237 0.455 1.000 25 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(2), GNAQ(1), GNB1(1), HTR2C(2), PLCB1(4), TUB(2) 7962830 12 12 12 1 4 1 5 1 1 0 0.151 0.459 1.000 26 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(2), LPL(1), NR3C1(2), PPARG(2), RXRA(1) 5923966 8 8 8 1 3 1 3 1 0 0 0.267 0.504 1.000 27 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5(1), DAB1(4), LRP8(3), RELN(19), VLDLR(4) 15826286 31 29 30 4 5 7 12 3 4 0 0.0568 0.509 1.000 28 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(1), DNAJC3(4), EIF2S1(1), EIF2S2(2), NFKB1(4), NFKBIA(1), RELA(1) 10374476 14 14 14 0 4 6 3 0 1 0 0.0102 0.525 1.000 29 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(2), CD3E(2), CD3G(2), CXCR3(5), ETV5(4), IFNG(2), IL12A(1), IL12B(1), IL12RB1(4), IL12RB2(1), IL18(1), IL18R1(2), JAK2(5), JUN(3), MAP2K6(1), MAPK14(2), MAPK8(2), STAT4(6), TYK2(5) 21186549 51 47 51 9 8 9 10 9 15 0 0.0875 0.529 1.000 30 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(3), ESR2(2), ITPKA(1), PDE1A(2), PDE1B(2), PLCB1(4), PLCB2(2), VIP(1) 12098506 17 17 17 2 2 6 3 3 3 0 0.119 0.530 1.000 31 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(2), ASL(4), CPS1(7), GLS(2) 8717627 15 15 15 2 2 4 5 3 1 0 0.154 0.542 1.000 32 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(4), HLCS(1) 3498453 5 5 5 0 1 1 3 0 0 0 0.205 0.543 1.000 33 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(4), IL4R(4), JAK1(4), JAK2(5), TYK2(5) 11591288 23 22 23 4 3 2 7 5 6 0 0.304 0.567 1.000 34 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL13RA2(4), IL4R(4), JAK1(4), JAK2(5), TYK2(5) 11591288 23 22 23 4 3 2 7 5 6 0 0.304 0.567 1.000 35 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH1C(1), ADH6(1), ADH7(3), ADHFE1(1) 6554782 7 7 7 1 3 2 2 0 0 0 0.298 0.582 1.000 36 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(4), CD8A(2), CSF1(3), IL11(1), IL2(1), IL6(2) 6806810 13 13 13 3 0 2 6 2 3 0 0.460 0.586 1.000 37 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), JAK1(4), JAK2(5), STAT1(1) 9460686 12 12 12 1 1 1 3 2 5 0 0.323 0.590 1.000 38 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(2), CCNH(2), CDC25A(1), CDC25B(3), CDC25C(2), CDK7(2), MNAT1(2), XPO1(4) 9760766 18 18 17 3 3 3 9 1 2 0 0.318 0.592 1.000 39 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 5 NFYB(1), NFYC(2), SP1(3), SP3(4) 5601216 10 10 10 2 0 2 1 4 3 0 0.529 0.610 1.000 40 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 9 CCL11(1), CCR3(1), CD4(4), IL5RA(2), IL6(2) 5170371 10 10 10 3 1 2 2 1 4 0 0.630 0.626 1.000 41 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 4 CDK5(1), FOSB(1), GRIA2(3) 3966413 5 5 5 1 0 2 2 1 0 0 0.469 0.629 1.000 42 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(4), IARS(7), LARS(2), LARS2(2), PDHA1(2), PDHA2(2), PDHB(1) 11533571 20 18 20 3 3 7 4 4 2 0 0.108 0.634 1.000 43 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2A(1), UBE2D2(3), UBE2D3(1), UBE2E1(1), UBE2E3(1), UBE2J1(3), UBE2J2(2), UBE2L6(1), UBE3A(2) 11614960 16 16 16 1 0 5 6 1 4 0 0.137 0.640 1.000 44 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(2) 1795419 2 2 2 0 0 0 1 0 1 0 0.553 0.654 1.000 45 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(3), HSD17B2(1), HSD17B4(6), HSD3B1(1), HSD3B2(3) 9142208 15 15 15 3 1 2 8 3 1 0 0.421 0.656 1.000 46 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(3), BAK1(2), BAX(2), BID(4), BIK(1), BIRC3(1), CASP6(2), CASP7(1), CASP9(1), DFFB(2) 13826468 19 18 18 1 3 7 1 0 8 0 0.0558 0.665 1.000 47 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(1), NDUFA4(1), NDUFB4(1), NDUFB5(3), NDUFS2(2), NDUFV1(3), NDUFV2(1) 8069600 13 13 13 2 4 1 2 4 2 0 0.334 0.683 1.000 48 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(1), TGDS(2), UGDH(1), UXS1(2) 4553659 6 5 6 0 1 3 1 1 0 0 0.126 0.692 1.000 49 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(3), MST1(4), MST1R(2) 6334411 9 8 9 0 2 2 3 0 2 0 0.0717 0.704 1.000 50 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 7 CCL11(1), CCR3(1) 2447812 2 2 2 0 0 1 0 0 1 0 0.578 0.704 1.000 51 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(4), PNPO(2) 5353689 6 6 6 1 0 0 3 1 2 0 0.625 0.707 1.000 52 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(2), COQ5(1), COQ6(2), NDUFA13(1) 4724867 6 6 6 0 0 1 4 1 0 0 0.257 0.714 1.000 53 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 15 DNAJA3(1), IFNG(2), IKBKB(4), JAK2(5), NFKB1(4), NFKBIA(1), RELA(1), TNFRSF1A(1), USH1C(5), WT1(2) 16655873 26 24 26 2 5 5 7 2 7 0 0.0181 0.717 1.000 54 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(1), TGDS(2), UGDH(1), UGP2(1), UXS1(2) 5760762 7 6 7 0 1 3 2 1 0 0 0.109 0.727 1.000 55 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 11 CASP9(1), CHUK(1), GH1(1), GHR(2), NFKB1(4), NFKBIA(1), PPP2CA(2), RELA(1) 10506220 13 12 13 1 4 5 2 0 2 0 0.0766 0.731 1.000 56 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1) 1750792 1 1 1 1 0 0 0 0 1 0 0.979 0.741 1.000 57 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(1), ST6GALNAC4(1), ST8SIA1(1) 5912382 11 11 11 3 2 4 2 2 1 0 0.372 0.744 1.000 58 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(4), NFKBIA(1), PLCB1(4), RELA(1) 9254455 11 11 11 1 3 3 3 0 2 0 0.143 0.750 1.000 59 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP5(2), ACP6(2), ACPP(5), ACPT(2), ENPP1(5), ENPP3(2), FLAD1(1), MTMR1(1), MTMR2(1), MTMR6(2), RFK(1), TYR(6) 17022927 30 29 29 4 4 6 13 4 3 0 0.0953 0.751 1.000 60 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2(4), F2R(3), F5(14), F7(1), FGA(5), FGB(1), FGG(4), PROC(1), PROS1(1), SERPINC1(4), TFPI(2) 18200086 40 38 40 6 4 7 16 7 6 0 0.0884 0.761 1.000 61 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 21 ATF1(2), CASP2(3), CHUK(1), IKBKB(4), JUN(3), LTA(1), MAP2K3(2), MAP2K6(1), MAPK14(2), MAPK8(2), NFKB1(4), NFKBIA(1), RELA(1), RIPK1(3), TANK(2), TNFRSF1A(1) 22044619 33 32 33 3 5 11 8 2 7 0 0.00323 0.764 1.000 62 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 1765846 1 1 1 1 1 0 0 0 0 0 0.933 0.775 1.000 63 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(3), CYP2E1(1), NR1I3(1), PTGS1(2), PTGS2(2) 5976859 9 9 8 2 4 1 3 0 1 0 0.367 0.775 1.000 64 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(2), ENO1(1), GPI(2), HK1(1), PFKL(1), PGK1(3), PKLR(3), TPI1(2) 9939461 15 15 15 3 2 3 2 4 4 0 0.161 0.779 1.000 65 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSS(2), NFKB1(4), NOX1(1), RELA(1), SOD1(1), XDH(4) 11019907 13 13 13 1 3 2 3 4 1 0 0.0865 0.780 1.000 66 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(3), GNAS(5), GNB1(1), PRKACA(2), PRKAR1A(4) 6662977 15 15 15 4 2 2 1 5 5 0 0.648 0.783 1.000 67 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(1), SUCLA2(1) 2360615 2 2 2 1 0 0 0 2 0 0 0.844 0.811 1.000 68 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(1), KHK(1), LCT(11), MPI(2), PGM1(1), PYGL(2), PYGM(5), TPI1(2), TREH(1) 15155437 26 26 26 4 5 2 6 6 7 0 0.0852 0.820 1.000 69 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 14 CHUK(1), CREBBP(7), EP300(7), HDAC3(1), IKBKB(4), NFKB1(4), NFKBIA(1), RELA(1), RIPK1(3), TNFRSF1A(1), TRAF6(3) 24286115 33 32 32 2 5 10 7 4 7 0 0.00160 0.828 1.000 70 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 TAT(2) 2978435 2 2 2 1 1 0 0 0 1 0 0.900 0.830 1.000 71 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 17 CCND1(1), CCNE1(1), CDK2(1), CDK4(1), CDK6(1), E2F1(4), MAPK1(1), MAPK3(1), NFKB1(4), NFKBIA(1), PAK1(2), RAF1(1), RELA(1), TFDP1(2) 14731479 22 22 21 3 7 5 4 3 3 0 0.0661 0.836 1.000 72 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(4), GBA(1), GBA3(2), LPO(5), MPO(3), TPO(5) 9401078 20 20 20 4 8 2 3 4 3 0 0.180 0.837 1.000 73 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(4), JAK2(5), JAK3(5), MAPK1(1), MAPK3(1), STAT3(3), TYK2(5) 12774329 24 22 24 4 5 4 5 3 7 0 0.170 0.839 1.000 74 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 18 APAF1(3), ATM(18), BAX(2), BID(4), CASP6(2), CASP7(1), CASP9(1), EIF2S1(1), PTK2(5), STAT1(1), TLN1(12) 29168666 50 48 49 6 6 14 9 5 16 0 0.0218 0.849 1.000 75 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), CHAT(1), PCYT1A(2), PDHA1(2), PDHA2(2), SLC18A3(2) 7149740 10 10 10 2 2 4 3 1 0 0 0.246 0.849 1.000 76 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), MAPK14(2), MAPK8(2), NFKB1(4), RELA(1), TNFSF13B(1), TRAF3(2), TRAF5(1), TRAF6(3) 16211554 17 17 17 1 2 6 3 2 3 1 0.0193 0.866 1.000 77 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 CREB1(1), JUN(3), KEAP1(2), MAPK1(1), MAPK14(2), MAPK8(2), NFE2L2(2) 9486454 13 13 13 3 3 2 2 0 5 1 0.331 0.866 1.000 78 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA3(3), PSMA5(1), PSMA6(1), PSMA7(1), PSMB5(1), PSMB6(2), PSMB8(1) 9269165 11 11 11 2 1 2 3 3 2 0 0.361 0.885 1.000 79 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(2), ALDH1A2(1), BCMO1(6), RDH5(1) 4364317 10 11 11 6 1 1 4 1 3 0 0.921 0.889 1.000 80 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP1(1), ARFGAP3(1), ARFGEF2(5), COPA(3), GBF1(7), GPLD1(3), KDELR2(1), KDELR3(1) 18446513 23 23 23 2 2 5 10 3 3 0 0.0258 0.900 1.000 81 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(3), EPOR(4), GRIN1(1), HIF1A(1), JAK2(5), NFKB1(4), NFKBIA(1), RELA(1) 13901350 20 20 20 3 2 5 6 2 5 0 0.189 0.903 1.000 82 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), GSTZ1(1), HGD(1) 2554068 3 3 3 2 1 0 0 2 0 0 0.894 0.904 1.000 83 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(1), ADORA2A(2), ADORA3(2), P2RY1(3), P2RY2(1), P2RY6(1) 6077131 10 10 10 3 3 2 3 2 0 0 0.370 0.906 1.000 84 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 4 PLCB1(4), PLCG1(6), VAV1(4) 9346920 14 14 14 3 4 3 3 1 3 0 0.305 0.908 1.000 85 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 14 ACTA1(2), APAF1(3), CASP9(1), DAXX(2), FAS(1), FASLG(2), IL1A(1), MAPKAPK2(1), MAPKAPK3(1) 12000081 14 14 14 2 2 4 5 1 2 0 0.222 0.913 1.000 86 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SRP54(1), SRP68(3), SRP72(1), SRPR(9) 8615968 14 12 14 3 1 4 3 4 2 0 0.404 0.913 1.000 87 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(6), RANGAP1(2) 9579891 9 9 9 0 0 3 3 1 2 0 0.174 0.913 1.000 88 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ARG1(2), GLS(2), PRODH(1) 6098317 5 5 5 1 2 0 1 0 2 0 0.575 0.915 1.000 89 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 13 CASP1(1), CASP7(1), GAPDH(1), INSR(4), ITCH(1), MAGI1(10), MAGI2(9), RERE(7), WWP1(2), WWP2(7) 22583041 43 43 38 7 9 9 6 7 11 1 0.0923 0.916 1.000 90 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 14 ADRB2(1), ANXA1(1), GNAS(5), GNB1(1), NFKB1(4), NOS3(3), NPPA(1), NR3C1(2), RELA(1) 14029803 19 19 19 3 4 5 4 3 3 0 0.163 0.918 1.000 91 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 11 APAF1(3), ARHGAP5(3), ARHGDIB(1), CASP1(1), CASP9(1), JUN(3), PRF1(2) 13174223 14 14 14 2 4 2 2 2 4 0 0.223 0.926 1.000 92 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(2), ACO2(3), AFMID(1), CS(1), GRHPR(1), HAO1(4), HAO2(1), MDH2(1), MTHFD1(5), MTHFD1L(4) 15330838 23 21 23 4 4 7 9 2 1 0 0.0972 0.927 1.000 93 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), TAT(2), TYR(6) 5338376 9 9 9 3 1 4 3 0 1 0 0.627 0.928 1.000 94 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 17 ATF2(2), CHUK(1), IFNG(2), IKBKB(4), IL2(1), JUN(3), MAP3K5(2), MAP4K5(1), MAPK14(2), MAPK8(2), NFKB1(4), NFKBIA(1), RELA(1), TNFRSF9(2) 19114688 28 26 28 4 6 7 8 1 6 0 0.0872 0.929 1.000 95 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(2), ACO2(3), CS(1), GRHPR(1), HAO1(4), HAO2(1), MDH2(1), MTHFD1(5), MTHFD1L(4) 14602403 22 20 22 4 3 7 9 2 1 0 0.125 0.930 1.000 96 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), CAT(1), EPX(4), LPO(5), MPO(3), PRDX1(1), PRDX5(1), SHMT2(1), TPO(5) 13170415 22 22 22 4 9 4 2 3 4 0 0.100 0.930 1.000 97 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(4), MAX(3), MYC(1), SP1(3), SP3(4), WT1(2) 6765870 17 16 17 5 3 2 2 5 5 0 0.616 0.931 1.000 98 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(7), CD44(2), CSF1(3), FCGR3A(1), IL6R(1), SELL(5), SPN(2), TGFB1(2), TNFRSF1A(1), TNFRSF8(2) 14639139 26 26 25 5 1 4 13 3 5 0 0.271 0.934 1.000 99 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS2(4), DHRS7(1), PON1(1), PON2(1), PON3(1), RDH11(2), RDH12(1), RDH14(2) 9990812 13 12 13 3 1 3 2 4 3 0 0.306 0.937 1.000 100 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(3), CAPN1(4), CDK5(1), CSNK1A1(1), MAPT(3), PPP2CA(2) 10344177 14 13 14 2 2 2 6 2 2 0 0.298 0.939 1.000 101 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(2), HK1(1), HK2(2), HK3(2), IMPA1(1), PGM1(1), PGM3(1), TGDS(2) 11373903 12 12 12 2 3 3 1 4 1 0 0.160 0.942 1.000 102 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(2), IL22(1), IL22RA1(2), IL22RA2(1), JAK1(4), JAK2(5), JAK3(5), STAT1(1), STAT3(3), STAT5A(4), STAT5B(5), TYK2(5) 20295706 38 36 38 6 10 3 11 3 11 0 0.0627 0.943 1.000 103 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(1), CYP11A1(1), CYP11B2(5), CYP17A1(1), HSD11B1(2), HSD3B1(1), HSD3B2(3) 7677187 14 14 14 4 3 0 8 3 0 0 0.457 0.943 1.000 104 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOSL2(2), IFNAR1(1), IFNAR2(1), IFNB1(1), MAPK8(2), NFKB1(4), RELA(1), TNFRSF11A(2), TRAF6(3) 11993574 17 17 17 4 4 6 2 3 2 0 0.197 0.944 1.000 105 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(1), ENO3(2), FARS2(1), PAH(2), TAT(2) 9415372 8 8 8 1 1 2 3 1 1 0 0.284 0.947 1.000 106 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(3), CD28(1), CD3E(2), CD3G(2), CD8A(2), ICAM1(1), ITGAL(1), ITGB2(4), PTPRC(3) 11800070 19 18 19 4 1 6 4 5 3 0 0.220 0.950 1.000 107 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 9 B2M(3), CD3E(2), CD3G(2), ICAM1(1), ITGAL(1), ITGB2(4), PRF1(2) 8714336 15 14 15 4 2 5 2 4 2 0 0.305 0.953 1.000 108 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(1), DFFB(2), HMGB1(1), HMGB2(3), TOP2A(2) 12027444 9 9 9 1 0 4 2 2 1 0 0.325 0.953 1.000 109 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(1), AASDHPPT(3), AASS(3) 8023299 7 7 7 2 1 1 3 0 2 0 0.807 0.953 1.000 110 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(3), BMPR1B(3), BMPR2(3) 6905501 9 8 8 3 0 2 1 1 5 0 0.579 0.954 1.000 111 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(18), CDC25A(1), CDC25B(3), CDC25C(2), MYT1(5), WEE1(2) 15792073 31 30 31 6 3 6 8 6 8 0 0.260 0.956 1.000 112 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASDHPPT(3), AASS(3) 5472377 6 6 6 2 1 1 3 0 1 0 0.806 0.957 1.000 113 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(4), ALDOB(2), ALDOC(1), GPT(3), GPT2(2), MDH2(1), ME2(2), ME3(2), PGK1(3), PKLR(3), PKM2(1), TKT(2), TPI1(2) 19895424 28 28 28 4 8 8 7 4 1 0 0.0189 0.957 1.000 114 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(1), MTMR2(1), MTMR6(2), NFS1(1), TPK1(1) 7225673 6 6 6 1 1 3 2 0 0 0 0.392 0.958 1.000 115 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(2), APOBEC1(1), APOBEC2(2), APOBEC3A(2), APOBEC3B(1), APOBEC3C(1), APOBEC3G(1), APOBEC4(1) 8405128 11 11 11 3 5 3 0 1 2 0 0.458 0.958 1.000 116 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 7 CTH(3), LDHC(2) 7384720 5 5 5 0 0 1 1 0 3 0 0.272 0.962 1.000 117 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(2), GGT1(4), SHMT2(1) 4620006 7 7 6 3 1 4 0 1 1 0 0.593 0.962 1.000 118 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(1), IFNG(2), JAK1(4), JAK2(5), PTPRU(5), REG1A(1), STAT1(1) 12909586 19 19 19 4 3 3 3 3 7 0 0.507 0.964 1.000 119 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(6), CS(1), PC(5), PDHA1(2), SLC25A1(1), SLC25A11(1) 10127063 16 14 16 3 2 5 4 3 2 0 0.177 0.964 1.000 120 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDC25B(3), CDK7(2), NEK1(1), WEE1(2) 8668966 9 9 9 2 1 2 5 1 0 0 0.596 0.965 1.000 121 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(4), GALNS(1), GLB1(2), GUSB(3), HEXA(1), HEXB(3), IDS(3), IDUA(1), LCT(11), NAGLU(1) 15710499 30 28 30 6 6 8 5 9 2 0 0.0915 0.967 1.000 122 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(4), GALNS(1), GLB1(2), GUSB(3), HEXA(1), HEXB(3), HGSNAT(4), HPSE(5), HPSE2(1), HYAL2(2), IDS(3), IDUA(1), LCT(11), NAGLU(1), SPAM1(2) 22538440 44 41 44 9 7 9 11 11 6 0 0.113 0.968 1.000 123 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(18), CDC25A(1), CDC25B(3), CDC25C(2), CDK2(1), CDK4(1), MYT1(5), WEE1(2) 17226937 33 32 33 6 3 6 8 7 9 0 0.230 0.969 1.000 124 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(2), CHPT1(3), HEMK1(1), LCMT1(1), LCMT2(5), METTL2B(2), PCYT1A(2), PCYT1B(3), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), WBSCR22(2) 15343038 33 28 33 6 5 10 11 3 4 0 0.0716 0.973 1.000 125 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 RDH11(2), RDH12(1), RDH14(2) 5260243 5 5 5 2 0 1 1 2 1 0 0.683 0.973 1.000 126 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(3), GAD1(2), TH(1) 6117601 6 6 6 2 1 1 2 1 1 0 0.732 0.974 1.000 127 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(1), IFNAR2(1), IFNB1(1), JAK1(4), STAT1(1), STAT2(2), TYK2(5) 12075678 16 16 16 4 3 4 3 2 4 0 0.420 0.976 1.000 128 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(4), COASY(5), DPYS(1), ENPP1(5), ENPP3(2), PANK1(1), PANK2(1), PANK4(3), UPB1(3) 15106402 25 24 25 5 2 5 6 6 6 0 0.315 0.976 1.000 129 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(1), CREBBP(7), DFFB(2), GZMA(2), HMGB2(3), PRF1(2), SET(1) 11943688 18 18 18 4 3 3 4 4 4 0 0.393 0.976 1.000 130 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 6 B3GNT1(1), FUT2(2), GCNT2(1), ST8SIA1(1) 6057719 5 5 4 5 0 0 1 1 3 0 0.966 0.977 1.000 131 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(4), GBA3(2), LPO(5), MPO(3), PRDX1(1), PRDX5(1), TPO(5), TYR(6) 10820109 27 26 27 6 8 6 5 4 4 0 0.169 0.977 1.000 132 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), FPGS(1), GCH1(1) 6316184 10 9 9 4 4 1 4 0 1 0 0.615 0.977 1.000 133 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA(1), GBA3(2), GGT1(4), SHMT2(1) 6258949 8 8 7 3 1 4 1 1 1 0 0.561 0.978 1.000 134 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(4), F2(4), F2R(3), FGA(5), FGB(1), FGG(4), PLAT(3), PLAU(2), PLG(4), SERPINE1(3) 15433587 34 33 34 8 1 5 19 5 4 0 0.450 0.979 1.000 135 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(1), CHAT(1), DBH(3), DDC(1), GAD1(2), GAD2(3), MAOA(2), PAH(2), SLC18A3(2), TH(1) 14866107 18 18 18 3 3 5 6 2 2 0 0.171 0.980 1.000 136 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), FARSA(1), FARSB(3), PAH(2), TAT(2), YARS2(1) 9847716 10 10 10 2 2 3 4 0 1 0 0.320 0.980 1.000 137 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(2), HK1(1), HK2(2), HK3(2), IMPA1(1), PGM1(1), PGM3(1), TGDS(2) 12672542 12 12 12 2 3 3 1 4 1 0 0.153 0.980 1.000 138 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 7 CD28(1), CD4(4), IL2(1) 3566959 6 6 6 3 1 1 2 1 1 0 0.828 0.980 1.000 139 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(6), G6PD(2), GCLC(2), GCLM(1), GGT1(4), GPX2(1), GPX4(1), GPX5(2), GSS(2), GSTA1(1), GSTA2(1), GSTA4(1), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(2), PGD(2) 19879962 33 31 32 5 7 6 6 9 5 0 0.0267 0.981 1.000 140 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 7 CD44(2), ICAM1(1), ITGAL(1), ITGAM(3), ITGB2(4), SELE(1), SELL(5) 12183341 17 16 17 4 0 2 7 4 4 0 0.460 0.981 1.000 141 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 9 ALDOA(4), ESR1(3), GREB1(3), MTA3(2) 10821293 12 12 12 3 1 5 3 1 2 0 0.301 0.983 1.000 142 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(7), EP300(7), ESR1(3), MAPK1(1), MAPK3(1), PELP1(2) 16649156 21 21 20 4 4 5 4 2 6 0 0.222 0.984 1.000 143 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(6), PTK2B(3) 7527227 10 10 10 3 1 3 3 1 2 0 0.444 0.985 1.000 144 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), AKR1D1(1), CYP11A1(1), CYP11B1(2), CYP11B2(5), CYP17A1(1), CYP21A2(3), HSD11B1(2), HSD3B1(1), HSD3B2(3) 9858751 21 21 21 5 6 2 11 2 0 0 0.257 0.986 1.000 145 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), AKR1D1(1), CYP11A1(1), CYP11B1(2), CYP11B2(5), CYP17A1(1), CYP21A2(3), HSD11B1(2), HSD3B1(1), HSD3B2(3) 9858751 21 21 21 5 6 2 11 2 0 0 0.257 0.986 1.000 146 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 14 APAF1(3), BIRC3(1), CASP7(1), CASP9(1), DFFB(2), PRF1(2), SCAP(3), SREBF1(1), SREBF2(4) 17980371 18 17 18 2 2 8 4 0 4 0 0.0620 0.986 1.000 147 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), CSF1(3), IL6(2), LDLR(1), LPL(1) 5878014 9 9 9 4 0 3 3 1 2 0 0.781 0.987 1.000 148 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(1), FDPS(1), IDI1(2), SQLE(1) 3766916 5 5 5 3 1 1 2 0 1 0 0.915 0.988 1.000 149 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(1), EPX(4), LPO(5), MPO(3), SHMT2(1), TPO(5) 12895954 20 20 20 4 9 3 2 3 3 0 0.142 0.988 1.000 150 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 16 CARS2(2), CDO1(1), CTH(3), LDHC(2), SULT1B1(1), SULT1C2(1) 13787147 10 10 10 1 0 3 2 0 5 0 0.295 0.988 1.000 151 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRB(1), IL10RA(2), IL10RB(4), IL1A(1), IL6(2), JAK1(4), STAT1(1), STAT3(3), STAT5A(4) 13440262 22 20 22 5 7 3 4 2 6 0 0.181 0.988 1.000 152 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(2), HADH(2), HADHB(2), HSD17B10(1), HSD17B4(6), PPT2(1) 9391173 14 13 14 4 0 5 6 2 1 0 0.563 0.989 1.000 153 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(7), AGT(2), BDKRB2(1), KNG1(4), NOS3(3), REN(1) 10454834 18 18 18 5 2 4 6 3 3 0 0.414 0.989 1.000 154 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1) 15120364 13 13 13 2 3 5 5 0 0 0 0.155 0.989 1.000 155 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 8 BAG4(1), BIRC3(1), RIPK1(3), TNFRSF1A(1) 6951395 6 6 6 2 0 2 1 0 3 0 0.685 0.990 1.000 156 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 11 CREBBP(7), DAXX(2), PAX3(2), PML(1), RARA(2), SIRT1(2), SP100(5), TNFRSF1A(1) 17276533 22 22 22 4 3 4 6 4 5 0 0.309 0.990 1.000 157 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(4), ABAT(3), ADSL(2), AGXT(1), AGXT2(1), ASL(4), ASNS(2), ASPA(2), CAD(10), CRAT(6), DARS(1), GAD1(2), GAD2(3), GPT(3), GPT2(2), NARS(1), PC(5) 28744332 52 47 52 7 7 15 18 6 6 0 0.00300 0.990 1.000 158 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 12 FUCA2(1), GLB1(2), HEXA(1), HEXB(3), LCT(11), MANBA(2), NEU2(1) 17013217 21 21 21 4 2 5 5 6 3 0 0.220 0.990 1.000 159 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(3), ADRB2(1), CFTR(9), GNAS(5), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), SLC9A3R1(2) 13926292 27 26 27 6 4 2 6 6 9 0 0.507 0.991 1.000 160 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA3(3), PSMA5(1), PSMA6(1), PSMA7(1), PSMB5(1), PSMB6(2), RPN1(2), UBE2A(1), UBE3A(2) 15146753 15 15 15 3 0 3 5 3 4 0 0.483 0.991 1.000 161 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP5(2), ACP6(2), ACPP(5), ACPT(2), ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), CYP3A4(3), CYP3A43(1), CYP3A7(4), DHRS2(4), DHRS7(1), PON1(1), PON2(1), PON3(1) 19702850 35 28 33 7 8 5 13 5 4 0 0.151 0.991 1.000 162 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), UGDH(1) 9285542 6 6 6 1 0 3 3 0 0 0 0.346 0.991 1.000 163 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(1), JUN(3), MAPK14(2), THBS1(4) 8056805 10 9 10 7 1 1 1 3 4 0 0.992 0.992 1.000 164 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA3(3), PSMA5(1), PSMA6(1), PSMA7(1), PSMB5(1), PSMB6(2), PSMD1(5), PSMD11(2), PSMD12(1), PSMD2(2), PSMD6(2) 18410354 22 22 22 4 2 4 8 4 4 0 0.317 0.992 1.000 165 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 19 CCNA1(1), CCNB1(2), CCND1(1), CCND3(2), CCNE1(1), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDK6(1), CDK7(2), E2F1(4), RBL1(3), TFDP1(2) 14924329 24 24 23 5 4 2 8 5 5 0 0.407 0.993 1.000 166 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2), OXCT1(1) 3880956 3 3 3 2 0 1 1 1 0 0 0.904 0.994 1.000 167 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(4), BCAT2(3), COASY(5), DPYS(1), ENPP1(5), ENPP3(2), ILVBL(1), PANK1(1), PANK2(1), PANK4(3), UPB1(3), VNN1(3) 18922659 32 31 32 7 4 6 7 8 7 0 0.256 0.994 1.000 168 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PLCD1(1), TGM2(2) 5470914 4 4 4 3 1 0 1 0 2 0 0.929 0.995 1.000 169 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3E(2), CD3G(2), IFNG(2), IL2(1), TGFB1(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TGFBR3(2), TOB1(3) 12166859 21 20 21 5 3 8 5 3 2 0 0.249 0.996 1.000 170 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(5), POLR2B(7), POLR2C(1), POLR2F(2), POLR2H(1), POLR2J(2) 14045927 20 19 17 9 3 1 3 3 10 0 0.877 0.996 1.000 171 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 9 CAT(1), GH1(1), GHR(2), IGF1(1), IGF1R(2), SHC1(1), SOD1(1) 9291206 9 9 9 3 2 2 5 0 0 0 0.561 0.996 1.000 172 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(2), B4GALNT1(1), GLB1(2), HEXA(1), HEXB(3), LCT(11), ST3GAL1(2), ST3GAL2(1), ST3GAL5(2), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(1), ST6GALNAC6(1), ST8SIA1(1) 17856135 30 30 30 7 5 7 6 8 4 0 0.225 0.996 1.000 173 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 20 APAF1(3), ARHGDIB(1), BIRC3(1), CASP1(1), CASP2(3), CASP4(1), CASP6(2), CASP7(1), CASP9(1), DFFB(2), LMNA(1), LMNB1(1), PRF1(2) 20006706 20 20 20 3 3 6 4 2 5 0 0.150 0.996 1.000 174 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 17 BAX(2), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8(2), NFKB1(4), NSMAF(1), RAF1(1), RELA(1), RIPK1(3), SMPD1(1), TNFRSF1A(1) 16981734 19 19 18 3 3 6 3 1 6 0 0.118 0.996 1.000 175 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 22 ARSA(1), ARSB(4), ARSE(2), ASAH1(1), GAL3ST1(1), GBA(1), GLA(4), GLB1(2), LCT(11), NEU2(1), PPAP2A(1), PPAP2C(2), SMPD1(1), SPTLC1(2), SPTLC2(2) 25220776 36 32 36 5 8 5 10 9 4 0 0.0422 0.996 1.000 176 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(1), B4GALT1(2), B4GALT3(1), B4GALT5(2), DPAGT1(2), DPM1(2), MAN1A1(1), MAN1B1(6), MGAT3(2), MGAT4A(1), MGAT4B(3), MGAT5(4), RPN1(2) 20779748 30 28 29 5 6 4 8 3 9 0 0.165 0.997 1.000 177 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(2), CDC25A(1), CDC25B(3), CDC25C(2), GRB2(1), PTPRA(2) 10294125 11 11 11 3 3 1 5 1 1 0 0.516 0.997 1.000 178 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 10 CD44(2), ICAM1(1), ITGA4(2), ITGAL(1), ITGAM(3), ITGB1(3), ITGB2(4), SELE(1), SELL(5), SELP(8) 18469955 30 28 30 7 2 4 11 9 4 0 0.374 0.997 1.000 179 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(2), GCK(2), GFPT1(2), GNE(3), GNPDA2(1), HEXA(1), HEXB(3), HK1(1), HK2(2), HK3(2), PGM3(1), RENBP(1), UAP1(1) 19085118 22 22 22 4 3 5 5 6 3 0 0.179 0.997 1.000 180 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(1), FDPS(1), IDI1(2), SQLE(1) 5008038 5 5 5 4 1 1 2 0 1 0 0.971 0.997 1.000 181 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), PAPSS1(2), SULT1A2(1), SULT1E1(2), SUOX(3) 7012955 9 9 9 3 2 5 0 1 1 0 0.609 0.998 1.000 182 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(3), ADRB2(1), GNAS(5), PLCE1(12), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RAP2B(2) 15840474 30 30 30 8 6 3 7 6 8 0 0.508 0.998 1.000 183 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(18), ATR(6), CDC25C(2), CHEK2(3) 17358703 29 28 29 5 3 6 4 8 8 0 0.241 0.998 1.000 184 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(18), ATR(6), BRCA1(12), BRCA2(14), CHEK2(3), FANCA(7), FANCC(1), FANCD2(5), FANCE(2), FANCF(1), FANCG(1), HUS1(1), MRE11A(2), RAD1(1), RAD17(2), RAD50(2), RAD51(2), RAD9A(2) 49161926 82 76 82 10 7 11 22 15 27 0 0.0224 0.998 1.000 185 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(6), NRG3(4), PSEN1(1) 10328413 11 11 11 3 1 4 4 1 1 0 0.515 0.998 1.000 186 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(2), PARK2(3), SNCAIP(3), UBE2F(1), UBE2L6(1) 7099745 10 10 10 4 1 2 5 2 0 0 0.809 0.998 1.000 187 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(2), GLUD2(2) 5001258 4 4 4 2 2 0 0 1 1 0 0.791 0.998 1.000 188 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(1), JUN(3), MAP2K1(1), MAPK1(1), MAPK3(1), MYC(1), NFKB1(4), NFKBIA(1), PLCB1(4), RAF1(1), RELA(1) 16716966 19 18 19 4 5 6 2 1 5 0 0.145 0.998 1.000 189 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 16 CD28(1), CD86(2), IFNG(2), IL12A(1), IL12B(1), IL12RB1(4), IL12RB2(1), IL18(1), IL18R1(2), IL2(1), IL4R(4) 13559574 20 19 20 6 3 2 8 5 2 0 0.573 0.998 1.000 190 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(7), C5(4), C6(5), C7(6), C9(1) 14680450 23 23 23 6 3 5 8 3 4 0 0.423 0.998 1.000 191 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(4), AARS2(4), ABAT(3), ADSL(2), AGXT(1), AGXT2(1), ASL(4), ASNS(2), ASPA(2), ASS1(1), CAD(10), CRAT(6), DARS(1), DARS2(2), DLD(1), GAD1(2), GAD2(3), GPT(3), GPT2(2), NARS(1), NARS2(2), PC(5), PDHA1(2), PDHA2(2), PDHB(1) 41803868 67 60 67 9 12 18 23 8 6 0 0.00123 0.998 1.000 192 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(5), GNB1(1), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1) 10397489 14 14 14 5 1 2 3 3 5 0 0.842 0.998 1.000 193 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 7 CAMK1(2), CAMK1G(1), HDAC9(5), MEF2B(1), MEF2C(3), MEF2D(2) 8021995 14 14 14 6 2 3 4 2 3 0 0.689 0.999 1.000 194 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(4), CD38(3), ENPP1(5), ENPP3(2), NMNAT1(1), NMNAT2(1), NNT(4), NT5E(5), NT5M(1) 16477866 26 26 26 7 2 1 14 5 4 0 0.591 0.999 1.000 195 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 17 BCR(3), CRKL(1), GRB2(1), JAK2(5), JUN(3), MAP2K1(1), MAPK3(1), MAPK8(2), MYC(1), RAF1(1), SOS1(4), STAT1(1), STAT5A(4), STAT5B(5) 21245005 33 33 33 7 7 4 7 4 11 0 0.167 0.999 1.000 196 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(4), BCAT2(3), IARS(7), IARS2(2), ILVBL(1), LARS(2), LARS2(2), PDHA1(2), PDHA2(2), PDHB(1) 18128619 26 24 26 5 5 7 6 5 3 0 0.135 0.999 1.000 197 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 11 CCNA1(1), CCNA2(3), CCND1(1), CCNE1(1), CCNE2(1), CDK2(1), CDK4(1), E2F1(4), PRB1(3) 8150665 16 16 16 6 5 3 2 3 3 0 0.624 0.999 1.000 198 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(3), EGFR(5), ERBB3(11), NRG1(2) 11626119 21 21 21 6 3 2 10 5 1 0 0.617 0.999 1.000 199 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT2(2), GBGT1(1), GLA(4), HEXA(1), HEXB(3), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), ST8SIA1(1) 10823740 17 17 16 6 3 4 3 2 5 0 0.480 0.999 1.000 200 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(7), EP300(7), LPL(1), NCOA1(2), NCOA2(3), PPARG(2), RXRA(1) 20754650 23 21 22 4 5 4 6 3 5 0 0.158 0.999 1.000 201 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 11 BCAR1(2), GRB2(1), ILK(2), ITGB1(3), MAPK1(1), MAPK3(1), PDK2(2), PTK2(5), SHC1(1), SOS1(4) 14503084 22 22 22 5 3 6 5 4 4 0 0.304 0.999 1.000 202 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 12 ABL1(5), E2F1(4), MDM2(2), MYC(1), POLR1A(6), POLR1B(2), POLR1C(2), POLR1D(4) 14341828 26 25 26 7 5 4 4 6 7 0 0.404 0.999 1.000 203 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(2), DHRS2(4), DHRS7(1), HEMK1(1), LCMT1(1), LCMT2(5), METTL2B(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), WBSCR22(2) 16248556 30 27 30 8 6 10 8 2 4 0 0.218 0.999 1.000 204 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(2), IMPDH1(2), POLB(1), POLD1(1), POLG(4), PRPS2(1), RRM1(2), SRM(1) 13694900 14 13 14 3 2 2 7 0 3 0 0.475 0.999 1.000 205 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 10 GRB2(1), IL2RG(1), IL4R(4), IRS1(2), JAK1(4), JAK3(5), RPS6KB1(2), SHC1(1), STAT6(2) 14503793 22 21 22 5 3 4 7 4 4 0 0.318 0.999 1.000 206 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(2), ALDH18A1(2), ARG1(2), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CKMT2(3), CPS1(7), GAMT(1), GATM(4), OTC(1) 19236150 29 29 29 6 4 6 11 7 1 0 0.198 0.999 1.000 207 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALNT1(1), B3GALT5(2), FUT2(2), GBGT1(1), GLA(4), HEXA(1), HEXB(3), ST3GAL1(2), ST3GAL2(1), ST8SIA1(1) 11488825 19 19 18 7 3 4 5 2 5 0 0.559 0.999 1.000 208 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(8), GABBR1(1), GPRC5A(1), GRM1(5), GRM2(3), GRM3(8), GRM4(1), GRM5(2), GRM7(3), GRM8(3) 21479340 35 32 35 7 9 7 11 3 5 0 0.0381 0.999 1.000 209 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 ANPEP(6), G6PD(2), GCLC(2), GCLM(1), GGT1(4), GPX2(1), GPX4(1), GPX5(2), GPX7(1), GSS(2), GSTA1(1), GSTA2(1), GSTA4(1), GSTK1(2), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), IDH1(2), TXNDC12(1) 22234778 35 33 34 7 7 7 8 8 5 0 0.0603 1.000 1.000 210 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(1), AOC3(3), CES1(2), ESD(1) 6413677 7 7 7 4 2 1 3 0 1 0 0.822 1.000 1.000 211 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 ARF1(1), CCND1(1), CDK2(1), CDK4(1), E2F1(4), MDM2(2), PRB1(3) 7284450 13 13 13 5 5 2 2 2 2 0 0.608 1.000 1.000 212 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CD4(4), CSF1(3), IFNA1(1), IFNB1(1), IFNG(2), IL11(1), IL12A(1), IL12B(1), IL15(2), IL1A(1), IL2(1), IL6(2), LTA(1), TGFB1(2), TGFB3(1) 13747820 24 23 24 7 3 6 8 3 4 0 0.452 1.000 1.000 213 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(3), CD28(1), CD3E(2), CD3G(2), CD4(4), ICAM1(1), ITGAL(1), ITGB2(4), PTPRC(3) 12582643 21 20 21 6 1 7 5 4 4 0 0.373 1.000 1.000 214 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CHIA(3), CMAS(2), CTBS(1), CYB5R1(2), GFPT1(2), GFPT2(3), GNE(3), GNPDA2(1), GNPNAT1(2), HEXA(1), HEXB(3), HK1(1), HK2(2), HK3(2), MTMR1(1), MTMR2(1), MTMR6(2), NAGK(1), NANS(1), PGM3(1), RENBP(1), UAP1(1) 32291826 38 37 38 5 5 10 9 9 5 0 0.0200 1.000 1.000 215 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(3), XYLT1(2), XYLT2(1) 6329092 7 7 7 3 4 0 0 2 1 0 0.684 1.000 1.000 216 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), HS3ST2(3), XYLT1(2), XYLT2(1) 6329092 7 7 7 3 4 0 0 2 1 0 0.684 1.000 1.000 217 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(2), ACO2(3), IDH1(2), MDH2(1), SDHB(1), SUCLA2(1) 10205370 10 10 10 4 2 1 3 4 0 0 0.717 1.000 1.000 218 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(2), ASNS(2), CA1(1), CA14(3), CA2(1), CA4(2), CA6(1), CA9(2), CPS1(7), CTH(3), GLS(2), GLUL(1), HAL(2) 21397292 29 29 29 6 2 4 9 7 7 0 0.205 1.000 1.000 219 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 17 B2M(3), IL18(1), ITGB1(3), KLRC1(3), KLRC3(1), LAT(1), MAP2K1(1), MAPK3(1), PAK1(2), PTK2B(3), SYK(2), VAV1(4) 16297921 25 25 25 6 4 5 10 5 1 0 0.325 1.000 1.000 220 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(4), ALDOB(2), ALDOC(1), GPT(3), GPT2(2), MDH2(1), ME3(2), PGK1(3), PKLR(3), PKM2(1), TKT(2), TKTL1(2), TKTL2(1), TPI1(2) 22314990 29 29 29 6 8 8 7 5 1 0 0.0698 1.000 1.000 221 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 36 APAF1(3), BAK1(2), BAX(2), BID(4), BIRC3(1), CASP2(3), CASP6(2), CASP7(1), CASP9(1), FAS(1), FASLG(2), JUN(3), MAPK10(2), MCL1(1), MDM2(2), MYC(1), NFKB1(4), NFKBIA(1), PARP1(3), PRF1(2), RELA(1), RIPK1(3), TNFRSF1A(1), TRAF1(1) 34290235 47 46 46 8 11 13 9 2 12 0 0.0294 1.000 1.000 222 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(6), AP2A1(6), AP2M1(4), DNM1(6), EPN1(1), EPS15(4), PICALM(1), PPP3CA(4), PPP3CB(3), SYNJ1(2), SYNJ2(1) 25202726 38 35 38 7 5 4 15 6 8 0 0.176 1.000 1.000 223 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CCR5(2), GNAQ(1), JUN(3), MAPK14(2), MAPK8(2), PLCG1(6), PTK2B(3) 15262681 19 19 19 7 3 3 5 1 7 0 0.665 1.000 1.000 224 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 11 CREB1(1), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K6(1), MAPK1(1), MAPK14(2), MAPK3(1), NFKB1(4), RELA(1), SP1(3) 11636167 18 18 18 5 4 6 4 3 1 0 0.353 1.000 1.000 225 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(3), ASPH(4), CREB1(1), EDN1(2), EP300(7), HIF1A(1), JUN(3), NOS3(3), P4HB(1) 18745634 25 24 24 6 3 5 5 4 8 0 0.470 1.000 1.000 226 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(2), FURIN(1), NOTCH1(5), PSEN1(1) 8242048 9 8 9 4 1 3 1 2 2 0 0.762 1.000 1.000 227 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 12 CARM1(2), CREB1(1), CREBBP(7), EP300(7), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RARA(2), RXRA(1) 19541565 27 26 26 7 5 3 6 4 9 0 0.444 1.000 1.000 228 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(6), PRKACG(1), PRKAR2A(1), PRKAR2B(1) 11307734 9 9 9 3 1 5 2 1 0 0 0.544 1.000 1.000 229 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(1), IL6(2), IL6R(1), JAK1(4), JAK2(5), JAK3(5), PTPRU(5), REG1A(1), STAT3(3) 16836850 27 26 27 8 4 5 5 4 9 0 0.546 1.000 1.000 230 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(1), IFNG(2), IL12A(1), IL12B(1), IL15(2), IL18(1), IL1A(1), IL2(1), IL6(2), LTA(1) 10867765 14 13 14 5 3 2 2 4 3 0 0.654 1.000 1.000 231 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 21 AOX1(4), CD38(3), ENPP1(5), ENPP3(2), NADK(1), NMNAT1(1), NMNAT2(1), NNT(4), NT5C1B(4), NT5C3(1), NT5E(5), NT5M(1), NUDT12(1) 23745898 33 33 33 8 4 1 16 7 5 0 0.410 1.000 1.000 232 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT1(2), B4GALT3(1), B4GALT5(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1) 8553637 13 12 13 5 2 4 4 1 2 0 0.722 1.000 1.000 233 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), BDH1(1), HMGCS1(3), HMGCS2(1), OXCT1(1), OXCT2(1) 8248642 9 9 9 5 0 2 3 3 1 0 0.914 1.000 1.000 234 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(2), CLOCK(1), CRY1(1), CRY2(1), CSNK1E(2), PER1(3) 9212257 10 10 10 4 1 2 2 3 2 0 0.814 1.000 1.000 235 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 16 ALOX12(2), ALOX15(2), ALOX15B(2), ALOX5(1), DPEP1(3), GGT1(4), PLA2G6(2), PTGIS(3), PTGS1(2), PTGS2(2), TBXAS1(1) 16474417 24 24 22 6 6 4 7 3 4 0 0.216 1.000 1.000 236 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 9 CD3E(2), CD3G(2), CD4(4), LCK(1), PTPRC(3), ZAP70(2) 9146933 14 14 14 9 2 6 3 1 2 0 0.911 1.000 1.000 237 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(1), JAK1(4), JAK2(5), JAK3(5), PIAS1(2), PTPRU(5), REG1A(1), SOAT1(1) 15345669 24 23 24 7 3 5 6 3 7 0 0.579 1.000 1.000 238 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), GPD2(1), NDUFA1(1), SDHB(1), UQCRC1(3) 7422810 7 7 7 6 1 0 2 3 1 0 0.985 1.000 1.000 239 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(4), ACACB(9), FASN(8), MCAT(1), OLAH(1), OXSM(1) 16625611 24 23 24 6 6 1 10 2 5 0 0.435 1.000 1.000 240 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 13 AKT2(3), AKT3(4), ELK1(2), GRB2(1), MAP2K1(1), MAP2K2(1), NGFR(1), NTRK1(4), PIK3CD(4), SHC1(1), SOS1(4) 13739791 26 25 26 9 6 4 8 2 6 0 0.530 1.000 1.000 241 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), CREM(2), JUN(3), MAPK3(1), OPRK1(2), POLR2A(5), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1) 14254026 21 21 21 8 6 0 6 3 6 0 0.782 1.000 1.000 242 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 21 BCAR1(2), CRK(1), GNAI1(1), GNAQ(1), GNB1(1), MAP2K1(1), MAPK1(1), MAPK3(1), NFKB1(4), PIK3C2G(3), PLCG1(6), PTK2(5), PTK2B(3), RAF1(1), RELA(1) 26894767 32 31 32 6 4 9 9 6 4 0 0.0865 1.000 1.000 243 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 16 CSNK2A1(1), ELK1(2), GRB2(1), JUN(3), KLK2(2), MAP2K1(1), MAPK3(1), MAPK8(2), NGFR(1), PLCG1(6), RAF1(1), SHC1(1), SOS1(4) 16610654 26 24 26 8 6 5 4 4 7 0 0.389 1.000 1.000 244 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 8 CD44(2), ICAM1(1), ITGA4(2), ITGAL(1), ITGB1(3), ITGB2(4), SELE(1), SELL(5) 13824709 19 19 19 6 0 1 8 7 3 0 0.742 1.000 1.000 245 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(2), ACO2(3), CS(1), DLD(1), DLST(3), IDH1(2), IDH3A(1), IDH3B(2), IDH3G(1), MDH2(1), PC(5), PCK1(2), SDHB(1), SUCLA2(1) 23285861 26 24 26 5 4 6 9 6 1 0 0.128 1.000 1.000 246 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(2), CAMK1G(1), CAMK2A(2), CAMK2D(4), CAMK2G(1), CAMK4(3), CAMKK1(3), CAMKK2(2), CREB1(1) 12835234 19 17 19 5 4 3 3 5 4 0 0.437 1.000 1.000 247 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1QB(1), C1S(2), C2(1), C3(7), C5(4), C6(5), C7(6), C9(1) 19483461 28 27 28 7 4 7 9 3 5 0 0.268 1.000 1.000 248 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 17 EIF4A2(6), EIF4B(1), EIF4G1(2), EIF4G2(2), EIF4G3(4), PDK2(2), PPP2CA(2), RPS6(2), RPS6KB1(2), TSC1(4), TSC2(2) 24603295 29 28 29 5 4 9 8 3 5 0 0.141 1.000 1.000 249 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 FLT3(3), IGF1(1), IL11(1), IL1A(1), IL6(2), KITLG(3), TGFB1(2), TGFB3(1) 9518312 14 12 14 6 2 4 4 2 2 0 0.710 1.000 1.000 250 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(1), IFNB1(1), JAK1(4), PTPRU(5), REG1A(1), STAT1(1), STAT2(2), TYK2(5) 13807981 20 20 20 6 5 4 3 3 5 0 0.545 1.000 1.000 251 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(2), ACOX3(2), ELOVL5(4), ELOVL6(3), FADS1(1), FADS2(4), FASN(8), SCD(1) 14880522 25 25 25 9 2 4 11 2 6 0 0.754 1.000 1.000 252 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(2), ASNS(2), CA1(1), CA14(3), CA2(1), CA4(2), CA6(1), CA9(2), CPS1(7), CTH(3), GLS(2), GLUD2(2), GLUL(1), HAL(2) 23843910 31 31 31 7 3 4 9 8 7 0 0.231 1.000 1.000 253 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(4), DARS(1), EPRS(4), FARS2(1), GARS(1), HARS(1), IARS(7), LARS(2), LARS2(2), MARS(2), NARS(1), QARS(3), RARS(3), SARS(3), TARS(5), WARS2(1) 36431020 41 40 41 6 7 10 11 9 4 0 0.0324 1.000 1.000 254 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(3), CBS(2), CTH(3), GGT1(4), MARS(2), MAT1A(1), MAT2B(1), PAPSS1(2), SEPHS1(1) 13522198 19 19 18 6 5 6 2 1 5 0 0.293 1.000 1.000 255 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(4), ALDOB(2), ALDOC(1), GCK(2), GMDS(2), HK1(1), HK2(2), HK3(2), KHK(1), MPI(2), PFKFB1(1), PFKFB3(1), PFKM(4), PFKP(2), SORD(2), TPI1(2) 26903027 33 33 33 7 6 8 6 7 6 0 0.0600 1.000 1.000 256 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT2(1), AGPAT3(2), AGPAT4(2), AGPAT6(2), AGPS(1), CHPT1(3), ENPP2(8), ENPP6(1), PAFAH1B1(3), PAFAH1B3(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLD1(5), PLD2(2), PPAP2A(1), PPAP2C(2) 26002660 50 47 50 10 7 8 16 13 6 0 0.0747 1.000 1.000 257 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS2(4), HMBS(1), PPOX(2) 8797329 7 7 7 3 2 2 3 0 0 0 0.816 1.000 1.000 258 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 9 GRB2(1), KLK2(2), NTRK1(4), PLCG1(6), SHC1(1), SOS1(4) 12115650 18 17 18 6 3 4 5 3 3 0 0.541 1.000 1.000 259 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(2), FADS2(4), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2) 11650010 23 22 23 8 3 3 10 5 2 0 0.700 1.000 1.000 260 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(1), GABRA2(1), GABRA3(3), GABRA4(1), GABRA5(2), GABRA6(3), PRKCE(2), SOD1(1) 8911312 14 14 14 9 2 2 5 4 1 0 0.931 1.000 1.000 261 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(1), GNAQ(1), GNAS(5), GNB1(1), LIMK1(4), MAP2K1(1), MAPK1(1), MAPK3(1), NOX1(1), PIK3C2G(3), PLCB1(4), PPP1R12B(1), PTK2(5), RAF1(1), ROCK2(4) 28644181 35 33 35 6 4 9 8 8 6 0 0.165 1.000 1.000 262 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(7), C5(4), C6(5), C7(6), ICAM1(1), IL1A(1), IL6(2), ITGA4(2), ITGAL(1), ITGB1(3), ITGB2(4), SELP(8), SELPLG(7), VCAM1(4) 27945041 55 52 52 14 7 9 15 12 12 0 0.322 1.000 1.000 263 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP14(2), MMP9(1), RECK(1), TIMP3(1) 8432822 5 5 5 8 1 1 2 0 1 0 0.996 1.000 1.000 264 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5(1), EGR1(1), KLK2(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NGFR(1), RAF1(1) 8682726 10 10 10 6 2 3 1 3 1 0 0.797 1.000 1.000 265 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(2), ADC(1), AGMAT(2), ALDH18A1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AMD1(1), AOC2(1), AOC3(3), ARG1(2), ARG2(1), ASL(4), ASS1(1), CPS1(7), GATM(4), MAOA(2), MAOB(1), OTC(1), SAT1(2), SAT2(1), SRM(1) 32554963 44 42 44 9 4 11 16 10 3 0 0.0826 1.000 1.000 266 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 11 CHUK(1), IKBKAP(7), IKBKB(4), NFKB1(4), NFKBIA(1), RELA(1), TNFAIP3(2), TRAF3(2), TRAF6(3) 17451010 25 24 25 7 2 8 8 2 4 1 0.415 1.000 1.000 267 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 14 FUCA2(1), GLB1(2), HEXA(1), HEXB(3), LCT(11), MAN2B1(3), MAN2B2(2), MANBA(2), NEU2(1) 21041196 26 25 26 7 3 5 8 6 4 0 0.394 1.000 1.000 268 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 16 CSF1(3), DDX20(2), E2F1(4), ETS1(3), ETS2(5), ETV3(3), HDAC2(4), HDAC5(3), JUN(3), RBL1(3), RBL2(1), SIN3A(4), SIN3B(5) 24270815 43 41 43 10 7 12 7 8 9 0 0.207 1.000 1.000 269 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 11 BPNT1(1), CHST11(2), PAPSS1(2), SULT1A2(1), SULT1E1(2), SUOX(3) 9737147 11 11 11 6 4 5 0 1 1 0 0.807 1.000 1.000 270 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(4), CPT1A(4), LEPR(4), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1) 16584567 18 18 18 8 6 1 5 1 5 0 0.915 1.000 1.000 271 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(3), ALDH5A1(1), CAD(10), CPS1(7), EPRS(4), GAD1(2), GAD2(3), GCLC(2), GCLM(1), GFPT1(2), GLS(2), GLUL(1), GMPS(2), GPT(3), GPT2(2), GSS(2), PPAT(1), QARS(3) 37403080 51 48 51 9 7 9 18 13 4 0 0.0560 1.000 1.000 272 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), GRB2(1), PTK2B(3), SHC1(1), SOS1(4) 9652345 10 10 10 5 2 3 3 1 1 0 0.797 1.000 1.000 273 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), CHST1(1), CHST2(3), ST3GAL1(2), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1) 12315093 18 18 18 9 4 6 3 2 3 0 0.858 1.000 1.000 274 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 16 CHUK(1), IKBKAP(7), IKBKB(4), LTA(1), NFKB1(4), NFKBIA(1), RELA(1), RIPK1(3), TANK(2), TNFAIP3(2), TRAF1(1), TRAF3(2) 21813684 29 28 29 8 3 9 11 0 5 1 0.294 1.000 1.000 275 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(2), ARPC1A(1), ARPC1B(2), ARPC2(2), WASF1(5), WASL(1) 9313728 13 12 13 7 1 5 6 0 1 0 0.931 1.000 1.000 276 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(3), AMD1(1), BHMT(1), CBS(2), CTH(3), DNMT1(4), DNMT3A(4), DNMT3B(2), MARS(2), MAT1A(1), MAT2B(1), MTAP(1), MTR(5), SRM(1), TAT(2) 22905639 33 32 33 9 8 7 7 4 7 0 0.267 1.000 1.000 277 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(3), BHMT(1), CBS(2), CTH(3), DNMT1(4), DNMT3A(4), DNMT3B(2), MARS(2), MAT1A(1), MAT2B(1), MTR(5) 19283356 28 27 28 8 7 5 6 4 6 0 0.330 1.000 1.000 278 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(3), GRB2(1), IL3RA(2), JAK2(5), MAP2K1(1), MAPK3(1), RAF1(1), SHC1(1), SOS1(4), STAT5A(4), STAT5B(5) 19554918 28 28 28 9 7 3 7 3 8 0 0.451 1.000 1.000 279 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(4), ALDOB(2), ALDOC(1), G6PD(2), GPI(2), H6PD(2), PFKM(4), PFKP(2), PGD(2), PGLS(2), PGM1(1), PGM3(1), PRPS2(1), TAL1(1), TKT(2) 21820367 29 29 29 8 7 5 4 7 6 0 0.259 1.000 1.000 280 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 14 CD28(1), CD3E(2), CD3G(2), CD86(2), CTLA4(1), GRB2(1), ICOS(1), IL2(1), ITK(4), LCK(1), PTPN11(1) 9394419 17 17 17 6 3 6 6 2 0 0 0.529 1.000 1.000 281 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5(1), DRD2(2), GRM1(5), PLCB1(4), PPP2CA(2), PPP3CA(4), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1) 17668255 25 24 25 8 3 3 9 4 6 0 0.695 1.000 1.000 282 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2AK4(4), EIF2B5(1), EIF2S1(1), EIF2S2(2), EIF2S3(2), EIF5(2) 12921433 13 13 13 7 1 4 4 2 2 0 0.940 1.000 1.000 283 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 21 ABL1(5), ATM(18), ATR(6), CCNA1(1), CCND1(1), CCNE1(1), CDC25A(1), CDK2(1), CDK4(1), CDK6(1), E2F1(4), HDAC1(4), SKP2(1), TFDP1(2), TGFB1(2), TGFB3(1) 29820484 50 47 49 10 6 9 9 10 16 0 0.214 1.000 1.000 284 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(3), CS(1), OGDH(4), SUCLA2(1) 10873579 9 8 9 4 0 3 5 1 0 0 0.706 1.000 1.000 285 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BFAR(2), BRAF(3), CREB1(1), CREB3(1), CREB5(1), MAPK1(1), RAF1(1), SNX13(3), TERF2IP(3) 13170738 17 17 17 5 3 2 5 5 2 0 0.652 1.000 1.000 286 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(3), LDLR(1), MBTPS1(2), MBTPS2(3), SCAP(3), SREBF1(1), SREBF2(4) 12265663 17 17 17 7 0 5 8 2 2 0 0.696 1.000 1.000 287 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 13 CREB1(1), GRB2(1), MAPK1(1), MAPK3(1), MEF2B(1), MEF2C(3), MEF2D(2), NTRK1(4), PLCG1(6), RPS6KA1(2), SHC1(1) 15036995 23 22 23 9 8 2 6 3 4 0 0.595 1.000 1.000 288 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 36 AKT2(3), AKT3(4), BCR(3), BLNK(1), BTK(4), CD19(3), DAG1(1), EPHB2(3), GRB2(1), ITPKA(1), ITPKB(7), LYN(4), MAP2K1(1), MAP2K2(1), MAPK1(1), NFAT5(6), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), PI3(1), PIK3CD(4), PLCG2(3), PPP1R13B(3), RAF1(1), SERPINA4(3), SHC1(1), SOS1(4), SOS2(4), SYK(2), VAV1(4) 51179768 83 77 83 14 17 16 23 13 13 1 0.00802 1.000 1.000 289 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 13 AKT2(3), AKT3(4), BPNT1(1), GRB2(1), ILK(2), MAPK1(1), MAPK3(1), PDK1(1), PIK3CD(4), PTK2B(3), RBL2(1), SHC1(1), SOS1(4) 17840738 27 26 27 7 5 7 7 2 6 0 0.320 1.000 1.000 290 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(1), POLD2(1), POLE(7), POLG(4), POLL(1), POLQ(8) 18518416 23 22 23 6 2 4 8 4 5 0 0.504 1.000 1.000 291 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(2), ARPC1A(1), ARPC1B(2), ARPC2(2), NCK1(1), NCKAP1(6), NTRK1(4), PIR(2), PSMA7(1), WASF1(5), WASF3(1), WASL(1) 17398517 28 27 28 8 4 7 12 4 1 0 0.521 1.000 1.000 292 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 FDFT1(1), FDPS(1), HMGCR(1), HMGCS1(3), IDI1(2), NSDHL(1), PMVK(1), SC4MOL(1), SQLE(1) 14617273 12 12 12 9 2 1 5 1 3 0 0.988 1.000 1.000 293 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 EHHADH(3), HADH(2), HSD17B10(1), HSD17B4(6), NTAN1(1), SIRT1(2), SIRT2(1), SIRT7(3), VNN2(4) 13344017 23 23 23 8 1 7 10 4 1 0 0.708 1.000 1.000 294 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(1), CALCR(1), CALCRL(2), CD97(5), CRHR1(2), CRHR2(1), ELTD1(4), EMR1(2), EMR2(5), GHRHR(2), GIPR(1), GLP2R(2), GPR64(6), LPHN1(3), LPHN2(6), LPHN3(8), VIPR2(1) 31085123 52 50 52 12 6 5 23 7 10 1 0.164 1.000 1.000 295 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(6), ACO1(2), ACO2(3), IDH1(2), MDH2(1), SUCLA2(1) 15097889 15 14 15 5 3 2 5 4 1 0 0.518 1.000 1.000 296 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 30 A1BG(2), AKT2(3), AKT3(4), BTK(4), GRB2(1), GSK3A(3), IARS(7), INPP5D(4), PDK1(1), PPP1R13B(3), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KB1(2), SHC1(1), SOS1(4), SOS2(4), TEC(2), YWHAB(1), YWHAG(1), YWHAZ(1) 35776593 58 55 58 11 15 10 18 8 7 0 0.0423 1.000 1.000 297 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 19 ADCY1(3), BAX(2), CSF2RB(3), IGF1(1), IGF1R(2), IL3RA(2), KIT(5), KITLG(3), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1) 18854369 28 27 27 9 4 6 9 3 6 0 0.520 1.000 1.000 298 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 12 ARPC1A(1), ARPC1B(2), ARPC2(2), PAK1(2), PDGFRA(3), WASL(1) 11118120 11 11 11 8 2 4 4 0 1 0 0.982 1.000 1.000 299 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ACAD9(1), ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), DHRS2(4), DHRS7(1), ESCO1(3), MYST3(4), MYST4(9), PNPLA3(2), SH3GLB1(1) 28246967 34 33 34 9 6 7 8 9 3 1 0.393 1.000 1.000 300 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(3), CS(1), DLD(1), DLST(3), IDH3A(1), IDH3B(2), IDH3G(1), MDH2(1), OGDH(4), PC(5), PDHA1(2), PDHA2(2), PDHB(1), PDHX(1), PDK1(1), PDK2(2), PDK4(2), PDP2(1), SDHB(1), SUCLA2(1) 32078177 36 34 36 7 6 9 12 7 2 0 0.0960 1.000 1.000 301 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 29 MAP2K7(1), MAPK1(1), MAPK10(2), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), PIK3CD(4), TRAF3(2), TRAF5(1), TRAF6(3) 29319913 36 34 36 8 8 7 7 6 6 2 0.133 1.000 1.000 302 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(4), DHRS7(1), ESCO1(3), MYST3(4), MYST4(9), PNPLA3(2), SH3GLB1(1) 18537327 24 23 24 8 3 4 5 8 3 1 0.694 1.000 1.000 303 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(4), ALDOB(2), ALDOC(1), DERA(1), G6PD(2), GPI(2), H6PD(2), PFKL(1), PFKM(4), PFKP(2), PGD(2), PGLS(2), PGM1(1), PGM3(1), PRPS2(1), TKT(2), TKTL1(2), TKTL2(1) 26336666 33 33 33 9 7 5 5 8 8 0 0.243 1.000 1.000 304 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 8 EGF(3), EGFR(5), MAP2K1(1), MAPK14(2), RARA(2), RXRA(1), THRA(1), THRB(1) 11562105 16 16 16 7 3 4 4 4 1 0 0.785 1.000 1.000 305 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 24 AKT2(3), AKT3(4), CISH(1), GRB2(1), IARS(7), IL13RA1(1), IL2RG(1), IL4R(4), INPP5D(4), JAK1(4), JAK2(5), JAK3(5), NR0B2(2), PI3(1), PPP1R13B(3), RPS6KB1(2), SERPINA4(3), SHC1(1), SOS1(4), SOS2(4), STAT6(2), TYK2(5) 37263371 67 61 67 13 14 10 19 9 15 0 0.0741 1.000 1.000 306 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(4), EGF(3), EGFR(5), HGS(4), TF(3), TFRC(1) 14360966 20 20 20 9 5 3 7 3 2 0 0.851 1.000 1.000 307 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(1), CREBBP(7), EP300(7), IKBKB(4), MAP2K3(2), MAP2K6(1), MAP3K7(1), MAPK14(2), NFKB1(4), NFKBIA(1), NR3C1(2), RELA(1), TGFBR1(2), TGFBR2(3), TLR2(1) 33002551 39 36 38 9 7 10 10 4 8 0 0.160 1.000 1.000 308 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 23 ARHGDIB(1), BAG4(1), CASP2(3), DFFB(2), JUN(3), LMNA(1), LMNB1(1), MADD(10), MAP3K7(1), MAPK8(2), PAK1(2), PAK2(2), PRKDC(10), RIPK1(3), SPTAN1(4), TNFRSF1A(1) 36619449 47 44 47 9 7 11 12 6 11 0 0.0928 1.000 1.000 309 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(4), ACTG2(2), ADCY3(3), ADCY9(9), ARF1(1), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(3), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), ERO1L(3), GNAS(5), PDIA4(3), PLCG1(6), PLCG2(3), SEC61A1(2), TRIM23(4) 41585883 61 57 61 11 10 7 23 9 12 0 0.0578 1.000 1.000 310 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(18), ATR(6), BRCA1(12), CCNB1(2), CDC25A(1), CDC25B(3), CDC25C(2), CHEK2(3), EP300(7), MDM2(2), MYT1(5), PRKDC(10), RPS6KA1(2), WEE1(2) 48243344 75 71 74 13 10 11 18 14 22 0 0.0674 1.000 1.000 311 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 61 APAF1(3), BAK1(2), BAX(2), BCL2L11(4), BID(4), BIRC3(1), CASP1(1), CASP2(3), CASP4(1), CASP6(2), CASP7(1), CASP9(1), CHUK(1), DFFB(2), FAS(1), FASLG(2), IKBKB(4), IRF1(1), IRF3(3), IRF5(1), IRF6(2), IRF7(1), JUN(3), LTA(1), MAPK10(2), MDM2(2), MYC(1), NFKB1(4), NFKBIA(1), NFKBIE(1), PLEKHG5(3), PRF1(2), RELA(1), RIPK1(3), TNFRSF1A(1), TNFRSF21(2), TNFRSF25(1), TP73(1), TRAF1(1), TRAF3(2) 55252649 75 70 74 10 11 22 16 7 18 1 0.00177 1.000 1.000 312 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 30 CHUK(1), IFNA1(1), IFNB1(1), IKBKB(4), IL1A(1), IL1R1(1), IL1RAP(7), IL1RN(3), IL6(2), IRAK1(2), IRAK2(3), IRAK3(1), JUN(3), MAP2K3(2), MAP2K6(1), MAP3K7(1), MAPK14(2), MAPK8(2), NFKB1(4), NFKBIA(1), RELA(1), TGFB1(2), TGFB3(1), TRAF6(3) 29968007 50 45 50 11 10 15 11 5 9 0 0.107 1.000 1.000 313 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1) 17343659 16 16 16 7 3 1 7 1 4 0 0.879 1.000 1.000 314 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1) 17343659 16 16 16 7 3 1 7 1 4 0 0.879 1.000 1.000 315 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1) 17343659 16 16 16 7 3 1 7 1 4 0 0.879 1.000 1.000 316 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 18 EIF4A2(6), EIF4G1(2), EIF4G2(2), EIF4G3(4), GHR(2), IRS1(2), MAPK1(1), MAPK14(2), MAPK3(1), PABPC1(3), PDK2(2), RPS6KB1(2) 24785683 29 28 29 7 4 11 8 0 6 0 0.309 1.000 1.000 317 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(1), CCR2(5), CCR3(1), CCR5(2), CCR7(3), CD28(1), CD4(4), CXCR3(5), IFNG(2), IL12A(1), IL12B(1), IL12RB1(4), IL12RB2(1), IL18R1(2), IL2(1), IL4R(4), TGFB1(2), TGFB3(1) 22974004 41 40 41 12 6 8 10 8 9 0 0.330 1.000 1.000 318 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(2), CLOCK(1), CRY1(1), CRY2(1), CSNK1E(2), NPAS2(2), NR1D1(2), PER1(3), PER2(3), PER3(3) 18523950 20 20 20 6 5 2 4 5 4 0 0.570 1.000 1.000 319 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 FDFT1(1), FDPS(1), HMGCR(1), IDI1(2), NQO1(1), NQO2(2), PMVK(1), SQLE(1), VKORC1(1) 12144925 11 11 11 8 3 2 5 0 1 0 0.973 1.000 1.000 320 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(3), PGAP1(5), PIGA(2), PIGB(1), PIGG(2), PIGM(1), PIGN(1), PIGO(1), PIGQ(3), PIGS(2), PIGT(1), PIGV(1), PIGW(3), PIGZ(2) 27747967 29 27 29 7 7 5 9 6 2 0 0.228 1.000 1.000 321 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 16 ADCY1(3), ARHGEF1(7), F2(4), F2R(3), GNAI1(1), GNAQ(1), GNB1(1), MAP3K7(1), PLCB1(4), PPP1R12B(1), PTK2B(3), ROCK1(4) 24108587 33 33 33 9 3 9 14 3 4 0 0.381 1.000 1.000 322 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 26 ACAA2(2), ADH1A(1), ADH1C(1), ADH6(1), ADH7(3), ADHFE1(1), AKR1C4(2), AKR1D1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), BAAT(2), CEL(2), CYP27A1(2), CYP7A1(1), HADHB(2), SRD5A1(1) 25713190 30 29 30 9 5 9 11 4 1 0 0.401 1.000 1.000 323 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 15 EIF2B5(1), EIF2S1(1), EIF2S2(2), EIF2S3(2), IGF1(1), IGF1R(2), INPPL1(4), PDK2(2), PPP2CA(2), RPS6(2), RPS6KB1(2) 15804730 21 21 21 7 3 7 7 1 3 0 0.503 1.000 1.000 324 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX12(2), ALOX15(2), ALOX5(1), CBR1(1), CYP4F2(2), EPX(4), GGT1(4), LPO(5), MPO(3), PLA2G2E(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PRDX1(1), PRDX5(1), PTGIS(3), PTGS1(2), PTGS2(2), TBXAS1(1), TPO(5) 30875978 52 50 51 11 15 5 16 7 9 0 0.0677 1.000 1.000 325 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), FDXR(1) 18175410 17 17 17 7 3 1 8 1 4 0 0.852 1.000 1.000 326 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 69 B2M(3), CALR(1), CANX(2), CD4(4), CD8A(2), CIITA(1), CREB1(1), CTSB(1), CTSS(1), HLA-C(2), HLA-DMA(1), HLA-DMB(2), HLA-E(1), HLA-F(4), HLA-G(2), HSP90AA1(2), HSP90AB1(3), IFI30(1), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), KIR2DL1(1), KIR2DL3(4), KIR2DL4(2), KIR2DS4(3), KIR3DL1(1), KIR3DL2(5), KIR3DL3(1), KLRC1(3), KLRC3(1), LTA(1), NFYB(1), NFYC(2), RFX5(1), RFXANK(2), TAP1(2) 43551814 78 73 78 18 7 20 27 9 15 0 0.103 1.000 1.000 327 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 12 GRB2(1), IGF1R(2), IRS1(2), MAP2K1(1), MAPK1(1), MAPK3(1), RAF1(1), SHC1(1), SOS1(4) 15051990 14 14 14 7 2 6 2 2 2 0 0.765 1.000 1.000 328 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(4), AARS2(4), CARS2(2), DARS(1), DARS2(2), EARS2(3), EPRS(4), FARS2(1), FARSA(1), FARSB(3), GARS(1), HARS(1), IARS(7), IARS2(2), LARS(2), LARS2(2), MARS(2), NARS(1), NARS2(2), PARS2(1), QARS(3), RARS(3), RARS2(2), SARS(3), SARS2(2), TARS(5), TARS2(6), WARS2(1), YARS2(1) 58540245 72 67 72 10 16 16 22 12 6 0 0.00430 1.000 1.000 329 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(2), CAMK2D(4), CAMK2G(1), DAG1(1), ITPKA(1), ITPKB(7), ITPR1(10), ITPR2(7), ITPR3(6), NFAT5(6), PDE6A(1), PDE6B(2), PDE6C(6), SLC6A13(3), TF(3) 40189530 60 60 60 13 4 14 16 17 9 0 0.0836 1.000 1.000 330 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 45 APAF1(3), BAX(2), BCL2L2(1), CASP1(1), CASP2(3), CASP4(1), CASP6(2), CASP7(1), CASP9(1), CD40(1), CD40LG(1), DAXX(2), DFFB(2), FAS(1), FASLG(2), IKBKE(2), LTA(1), MCL1(1), NFKB1(4), NFKBIA(1), NGFR(1), NR3C1(2), NTRK1(4), PTPN13(5), RIPK1(3), SFRS2IP(4), TFG(1), TNFRSF1A(1), TRAF1(1), TRAF3(2), TRAF6(3) 46896270 60 55 59 10 7 19 14 6 13 1 0.0126 1.000 1.000 331 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 18 CSNK2A1(1), ELK1(2), GRB2(1), IGF1(1), IGF1R(2), IRS1(2), JUN(3), MAP2K1(1), MAPK3(1), MAPK8(2), PTPN11(1), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SRF(1) 22592624 26 25 26 9 5 6 7 2 6 0 0.586 1.000 1.000 332 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 21 BTK(4), DLG4(1), EPHB2(3), F2(4), F2RL2(1), JUN(3), MAP2K5(2), MAPK1(1), MAPK8(2), MYEF2(3), PLD1(5), PLD2(2), PLD3(2), PTK2(5), RAF1(1), RASAL1(2), TEC(2), VAV1(4) 30484081 47 42 47 10 8 9 15 6 9 0 0.123 1.000 1.000 333 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(1), B3GAT2(1), B3GAT3(1), CHPF(1), CHST11(2), CHST3(1), CHSY1(1), DSE(8), UST(3), XYLT1(2), XYLT2(1) 13357388 22 22 22 8 9 5 4 3 1 0 0.508 1.000 1.000 334 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 20 ANPEP(6), CD2(3), CD33(1), CD5(2), IFNA1(1), IFNB1(1), IFNG(2), IL12A(1), IL12B(1), ITGAX(5), TLR2(1), TLR7(8), TLR9(1) 18851210 33 33 33 10 8 8 3 7 7 0 0.338 1.000 1.000 335 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 66 MRPL13(1), MRPS7(2), RPL10L(2), RPL13A(3), RPL14(1), RPL18(4), RPL18A(2), RPL19(1), RPL26(2), RPL29(1), RPL3(1), RPL35(2), RPL3L(1), RPL41(1), RPL7(1), RPL8(1), RPS10(1), RPS16(1), RPS2(1), RPS21(1), RPS27(1), RPS5(4), RPS6(2), RPSA(1) 25173384 38 36 37 9 5 5 14 7 7 0 0.537 1.000 1.000 336 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(3), CARM1(2), CBS(2), CTH(3), GGT1(4), HEMK1(1), LCMT1(1), LCMT2(5), MARS(2), MAT1A(1), MAT2B(1), METTL2B(2), PAPSS1(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), SEPHS1(1), SEPHS2(1), WBSCR22(2) 27059148 45 40 44 12 11 15 10 1 8 0 0.0964 1.000 1.000 337 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(3), ARHGEF1(7), GNAQ(1), GNB1(1), MYLK(8), PLCB1(4), PPP1R12B(1), ROCK1(4) 23463001 29 29 29 8 4 7 9 4 5 0 0.384 1.000 1.000 338 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(2), BRAF(3), CREB1(1), CREB3(1), CREB5(1), DUSP4(1), DUSP6(1), DUSP9(1), EEF2K(4), GRB2(1), MAP2K1(1), MAP2K2(1), MAP3K8(2), MAPK1(1), MAPK3(1), MOS(3), NFKB1(4), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), SHC1(1), SOS1(4), SOS2(4), TRAF3(2) 33045893 50 46 50 11 14 8 12 8 7 1 0.0846 1.000 1.000 339 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADVL(3), ACSL1(1), ACSL3(1), ACSL4(2), CPT1A(4), CPT2(5), EHHADH(3), SLC25A20(1) 18856392 20 20 20 7 3 7 5 2 3 0 0.643 1.000 1.000 340 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ARG1(2), ARG2(1), ASL(4), ASS1(1), CKB(1), CKMT1B(1), CKMT2(3), CPS1(7), DAO(1), EPRS(4), GAMT(1), GATM(4), GLUD2(2), LAP3(1), NOS1(7), NOS3(3), OTC(1), P4HA1(1), P4HA2(1), P4HA3(2), PARS2(1), PRODH(1), PYCR2(1), RARS(3), RARS2(2) 39433355 56 55 56 11 11 10 23 8 4 0 0.0639 1.000 1.000 341 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(3), UCHL3(1), UGDH(1), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2B15(3), UGT2B4(2) 19910024 21 21 21 9 2 4 4 8 3 0 0.782 1.000 1.000 342 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CSNK2A1(1), ELK1(2), GRB2(1), IL6(2), IL6R(1), IL6ST(6), JAK1(4), JAK2(5), JAK3(5), JUN(3), MAP2K1(1), MAPK3(1), PTPN11(1), RAF1(1), SHC1(1), SOS1(4), SRF(1), STAT3(3) 26223925 43 40 43 10 6 7 12 7 11 0 0.272 1.000 1.000 343 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 19 ADCY1(3), ASAH1(1), GNAI1(1), GNB1(1), ITGAV(6), ITGB3(3), MAPK1(1), MAPK3(1), PDGFRA(3), PLCB1(4), PTK2(5), SMPD1(1) 25102326 30 28 30 9 5 8 7 5 5 0 0.521 1.000 1.000 344 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 14 CREBBP(7), EP300(7), IL2RG(1), IL7R(4), JAK1(4), JAK3(5), LCK(1), PTK2B(3), STAT5A(4), STAT5B(5) 27148762 41 39 40 10 7 5 13 7 9 0 0.238 1.000 1.000 345 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 20 F2(4), F2R(3), GNAI1(1), GNB1(1), ITGA1(5), ITGB1(3), MAP2K1(1), MAPK1(1), MAPK3(1), PLA2G4A(7), PLCB1(4), PTGS1(2), PTK2(5), RAF1(1), SYK(2), TBXAS1(1) 27122565 42 37 42 11 5 7 21 6 3 0 0.444 1.000 1.000 346 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 23 ATF2(2), BCR(3), BLNK(1), ELK1(2), GRB2(1), JUN(3), LYN(4), MAP2K1(1), MAPK1(1), MAPK3(1), MAPK8IP3(3), PAPPA(9), RPS6KA1(2), RPS6KA3(4), SHC1(1), SOS1(4), SYK(2), VAV1(4), VAV2(2), VAV3(4) 31488213 54 51 54 13 16 9 16 7 6 0 0.0932 1.000 1.000 347 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 18 CASP9(1), CHUK(1), ELK1(2), MAP2K1(1), MAPK3(1), NFKB1(4), RAF1(1), RALBP1(1), RALGDS(1), RELA(1), RHOA(2) 16070650 16 16 16 7 5 4 3 3 1 0 0.662 1.000 1.000 348 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 30 AKT2(3), AKT3(4), BCR(3), BTK(4), CD19(3), FLOT1(1), FLOT2(2), GAB1(2), ITPR1(10), ITPR2(7), ITPR3(6), LYN(4), NR0B2(2), PDK1(1), PHF11(1), PITX2(3), PLCG2(3), PPP1R13B(3), PREX1(10), PTPRC(3), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KB1(2), SAG(1), SYK(2), TEC(2), VAV1(4) 57592385 96 86 96 19 20 17 28 18 13 0 0.00975 1.000 1.000 349 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 28 CD14(2), CHUK(1), ELK1(2), IKBKB(4), IRAK1(2), JUN(3), MAP2K3(2), MAP2K6(1), MAP3K7(1), MAPK14(2), MAPK8(2), NFKB1(4), NFKBIA(1), PPARA(2), RELA(1), TIRAP(1), TLR10(1), TLR2(1), TLR3(5), TLR7(8), TLR9(1), TRAF6(3) 34235851 50 48 50 12 9 12 11 6 12 0 0.137 1.000 1.000 350 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 30 APAF1(3), BID(4), BIRC3(1), CASP6(2), CASP7(1), CASP9(1), CHUK(1), DFFB(2), LMNA(1), NFKB1(4), NFKBIA(1), RELA(1), RIPK1(3), SPTAN1(4), TNFRSF25(1) 35577718 30 29 30 6 6 10 5 2 7 0 0.135 1.000 1.000 351 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(3), ADC(1), ALDH5A1(1), CAD(10), CPS1(7), EARS2(3), EPRS(4), GAD1(2), GAD2(3), GCLC(2), GCLM(1), GFPT1(2), GFPT2(3), GLS(2), GLUD2(2), GLUL(1), GMPS(2), GNPNAT1(2), GPT(3), GPT2(2), GSS(2), NAGK(1), PPAT(1), QARS(3) 44573096 63 59 63 13 10 11 20 17 5 0 0.0667 1.000 1.000 352 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 21 ALDH1A3(3), ALDH3B2(2), AOC2(1), AOC3(3), DDC(1), EPX(4), HPD(2), LPO(5), MAOA(2), MAOB(1), MPO(3), PRDX1(1), PRDX5(1), TAT(2), TPO(5) 23609061 36 34 36 10 11 5 8 4 8 0 0.271 1.000 1.000 353 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 35 ARSA(1), ARSE(2), ASAH1(1), B4GALT6(1), CERK(1), DEGS1(3), DEGS2(1), ENPP7(3), GAL3ST1(1), GBA(1), GLA(4), GLB1(2), LCT(11), NEU2(1), PPAP2A(1), PPAP2C(2), SGMS1(1), SGPP1(1), SGPP2(1), SMPD1(1), SMPD3(1), SMPD4(1), SPHK2(2), SPTLC1(2), SPTLC2(2), UGT8(2) 36669335 50 47 50 12 8 9 14 12 6 1 0.205 1.000 1.000 354 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 18 CHUK(1), IKBKB(4), IL1A(1), IL1R1(1), IRAK1(2), MAP3K7(1), NFKB1(4), NFKBIA(1), RELA(1), RIPK1(3), TNFAIP3(2), TNFRSF1A(1), TRAF6(3) 21045143 25 24 25 9 3 8 7 4 3 0 0.622 1.000 1.000 355 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(6), ACO1(2), ACO2(3), CLYBL(3), CS(1), DLD(1), DLST(3), IDH1(2), IDH3A(1), IDH3B(2), IDH3G(1), MDH2(1), OGDH(4), OGDHL(4), PC(5), PCK1(2), PCK2(3), SDHB(1), SUCLA2(1) 33848098 46 42 46 10 7 9 18 10 2 0 0.0874 1.000 1.000 356 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1QB(1), C1S(2), C2(1), C3(7), C5(4), C6(5), C7(6), C9(1), MASP1(3), MASP2(2), MBL2(1) 23892391 34 33 34 10 6 7 10 4 7 0 0.369 1.000 1.000 357 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 48 ACTG1(4), APAF1(3), ARHGDIB(1), BAG4(1), BID(4), BIRC3(1), CASP2(3), CASP6(2), CASP7(1), CASP9(1), CHUK(1), DAXX(2), DFFB(2), GSN(1), LMNA(1), LMNB1(1), MAP2K7(1), MAP3K5(2), MAPK8(2), MDM2(2), NFKB1(4), NFKBIA(1), NUMA1(5), PAK2(2), PRKCD(2), PRKDC(10), PSEN1(1), PSEN2(3), PTK2(5), RASA1(2), RELA(1), RIPK1(3), SPTAN1(4), TNFRSF1A(1), TRAF1(1) 71008644 81 77 81 11 14 18 19 11 19 0 0.00348 1.000 1.000 358 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 22 ATM(18), BMPR1B(3), CDK4(1), DMC1(2), EGR1(1), ESR2(2), FSHR(4), GJA4(1), INHA(1), LHCGR(5), MLH1(3), MSH5(2), NRIP1(3), PGR(5), PRLR(1), SMPD1(1), ZP2(2) 31750001 55 50 55 14 5 13 12 12 13 0 0.308 1.000 1.000 359 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), B4GALT1(2), G6PC(1), G6PC2(2), GAA(2), GALK2(1), GALT(1), GANC(2), GCK(2), GLA(4), GLB1(2), HK1(1), HK2(2), HK3(2), LCT(11), MGAM(12), PFKL(1), PFKM(4), PFKP(2), PGM1(1), PGM3(1), RDH11(2), RDH12(1), RDH14(2), UGP2(1) 42158438 64 62 64 16 11 12 11 20 10 0 0.0724 1.000 1.000 360 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 12 ERCC3(2), GTF2A1(1), HDAC3(1), NCOA1(2), NCOA2(3), POLR2A(5), RARA(2), RXRA(1), TBP(1) 20466652 18 18 18 7 3 2 5 5 3 0 0.758 1.000 1.000 361 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(1), GRIN1(1), GRIN2A(12), GRIN2B(9), GRIN2C(4), GRIN2D(4), NOS1(7), PPP3CA(4), PPP3CB(3), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1) 28078190 52 48 52 15 10 4 23 7 8 0 0.344 1.000 1.000 362 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(4), ALDOB(2), ALDOC(1), DLD(1), ENO1(1), ENO3(2), G6PC(1), GAPDH(1), GCK(2), GPI(2), HK1(1), HK2(2), HK3(2), LDHC(2), MDH2(1), PC(5), PCK1(2), PDHA1(2), PDHA2(2), PDHB(1), PDHX(1), PFKL(1), PFKM(4), PFKP(2), PGAM2(1), PGK1(3), PKLR(3), PKM2(1), TPI1(2) 46892082 55 53 55 11 9 17 12 10 7 0 0.0114 1.000 1.000 363 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BTK(4), ELK1(2), FCER1A(4), GRB2(1), JUN(3), LYN(4), MAP2K1(1), MAP2K7(1), MAPK1(1), MAPK3(1), MAPK8(2), NFATC2(2), NFATC3(4), NFATC4(5), PAK2(2), PLA2G4A(7), PLCG1(6), PPP3CA(4), PPP3CB(3), RAF1(1), SHC1(1), SOS1(4), SYK(2), VAV1(4) 38550720 69 63 69 17 11 16 20 11 11 0 0.135 1.000 1.000 364 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 37 ACAA2(2), ACAD8(1), ACAD9(1), ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), AKR1C4(2), AKR1D1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), BAAT(2), CEL(2), CYP27A1(2), CYP7A1(1), HADHB(2), LIPA(1), RDH11(2), RDH12(1), RDH14(2), SLC27A5(3), SOAT1(1), SRD5A1(1) 35106899 40 40 40 10 7 12 11 7 3 0 0.171 1.000 1.000 365 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 24 BRCA1(12), CARM1(2), CCND1(1), CREBBP(7), EP300(7), ERCC3(2), ESR1(3), GRIP1(3), GTF2A1(1), HDAC1(4), HDAC2(4), HDAC3(1), HDAC4(2), HDAC5(3), HDAC6(6), MEF2C(3), NRIP1(3), PELP1(2), POLR2A(5), SRA1(1), TBP(1) 47958414 73 69 72 17 8 16 19 8 22 0 0.205 1.000 1.000 366 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 47 ADORA3(2), ALG6(1), CCKBR(1), CCR2(5), CCR3(1), CCR5(2), CELSR1(6), CELSR2(10), CELSR3(7), CHRM2(4), CHRM3(1), CIDEB(2), CXCR3(5), EDNRA(1), EMR2(5), EMR3(3), F2R(3), FSHR(4), GHRHR(2), GPR116(3), GPR132(2), GPR133(2), GPR143(4), GPR17(2), GPR55(1), GPR56(1), GPR61(1), GPR77(1), GPR84(3), GRM1(5), GRPR(1), HRH4(1), LGR6(3), LPHN2(6), LPHN3(8), LTB4R2(1), P2RY11(1), P2RY13(3), PTGFR(1), SMO(2), SSTR2(1), TAAR5(3), TSHR(4) 67413213 125 108 126 28 24 25 27 26 23 0 0.00397 1.000 1.000 367 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 31 AKT2(3), AKT3(4), ARHGEF11(3), DLG4(1), LPA(11), MAP3K5(2), MAPK8(2), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), PDK1(1), PHKA2(9), PI3(1), PIK3CB(6), PLD1(5), PLD2(2), PLD3(2), PTK2(5), RDX(1), ROCK1(4), ROCK2(4), SERPINA4(3), SRF(1) 49243632 79 68 79 15 15 16 27 5 15 1 0.0288 1.000 1.000 368 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 28 ARSB(4), FUCA2(1), GALNS(1), GBA(1), GLB1(2), GUSB(3), HEXA(1), HEXB(3), HGSNAT(4), HPSE(5), HPSE2(1), HYAL2(2), IDS(3), IDUA(1), LCT(11), MAN2B1(3), MAN2B2(2), MANBA(2), NAGLU(1), NEU2(1), SPAM1(2) 36479856 54 50 54 14 8 10 17 11 8 0 0.264 1.000 1.000 369 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 24 APC(5), ASAH1(1), CERK(1), CREB1(1), CREB3(1), CREB5(1), DAG1(1), EPHB2(3), GNAQ(1), ITPKA(1), ITPKB(7), JUN(3), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK8(2), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3) 29155321 39 38 39 11 8 5 8 10 8 0 0.437 1.000 1.000 370 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX15(2), ALOX5(1), CYP1A2(3), CYP2C18(2), CYP2C19(1), CYP2C8(3), CYP2C9(2), CYP2E1(1), CYP3A4(3), CYP3A43(1), CYP3A7(4), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), RDH11(2), RDH12(1), RDH14(2) 26952869 43 41 42 12 7 7 14 7 8 0 0.293 1.000 1.000 371 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 52 ACYP1(1), ADH1A(1), ADH1C(1), ADH6(1), ADH7(3), ADHFE1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH3B2(2), ALDH9A1(1), ALDOA(4), ALDOB(2), ALDOC(1), DLD(1), ENO1(1), ENO3(2), G6PC(1), GAPDH(1), GCK(2), GPI(2), HK1(1), HK2(2), HK3(2), LDHC(2), PDHA1(2), PDHA2(2), PDHB(1), PFKM(4), PFKP(2), PGK1(3), PGM1(1), PGM3(1), PKLR(3), PKM2(1), TPI1(2) 54042472 64 62 64 14 12 20 17 10 5 0 0.0192 1.000 1.000 372 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 52 ACYP1(1), ADH1A(1), ADH1C(1), ADH6(1), ADH7(3), ADHFE1(1), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH3B2(2), ALDH9A1(1), ALDOA(4), ALDOB(2), ALDOC(1), DLD(1), ENO1(1), ENO3(2), G6PC(1), GAPDH(1), GCK(2), GPI(2), HK1(1), HK2(2), HK3(2), LDHC(2), PDHA1(2), PDHA2(2), PDHB(1), PFKM(4), PFKP(2), PGK1(3), PGM1(1), PGM3(1), PKLR(3), PKM2(1), TPI1(2) 54042472 64 62 64 14 12 20 17 10 5 0 0.0192 1.000 1.000 373 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 18 EXT1(5), EXT2(6), EXTL3(4), GLCE(4), HS2ST1(2), HS3ST2(3), HS3ST5(4), HS6ST2(5), HS6ST3(1), NDST3(2) 22372477 36 34 36 10 5 5 8 11 7 0 0.465 1.000 1.000 374 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 62 APAF1(3), ATM(18), ATR(6), BAI1(9), BAX(2), BID(4), CASP9(1), CCNB1(2), CCNB3(7), CCND1(1), CCND3(2), CCNE1(1), CCNE2(1), CCNG2(2), CDK2(1), CDK4(1), CDK6(1), CHEK2(3), DDB2(1), EI24(1), FAS(1), GTSE1(7), IGF1(1), IGFBP3(1), LRDD(1), MDM2(2), MDM4(3), PERP(2), PPM1D(2), RCHY1(1), RRM2(1), SERPINE1(3), SESN2(2), SIAH1(3), STEAP3(2), THBS1(4), TP53I3(1), TP73(1), TSC2(2) 67853243 107 92 106 21 18 18 19 23 29 0 0.0816 1.000 1.000 375 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 25 ADRBK1(2), AKT2(3), AKT3(4), DAG1(1), GNAQ(1), ITPKA(1), ITPKB(7), ITPR1(10), ITPR2(7), ITPR3(6), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), PDK1(1), PHKA2(9), PIK3CB(6), PITX2(3), PLD1(5), PLD2(2), PLD3(2) 48106413 79 70 79 19 11 16 23 15 13 1 0.0806 1.000 1.000 376 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(1), ELK1(2), GRB2(1), IL2(1), IL2RB(1), IL2RG(1), JAK1(4), JAK3(5), JUN(3), LCK(1), MAP2K1(1), MAPK3(1), MAPK8(2), RAF1(1), SHC1(1), SOS1(4), STAT5A(4), STAT5B(5), SYK(2) 25808241 41 39 41 12 9 5 12 5 10 0 0.311 1.000 1.000 377 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), AGK(2), AGPAT1(1), AGPAT2(1), AGPAT3(2), AGPAT4(2), AGPAT6(2), AKR1B1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CEL(2), DAK(3), DGAT1(1), DGAT2(2), DGKA(3), DGKB(4), DGKD(3), DGKE(2), DGKG(6), DGKH(1), DGKI(7), DGKQ(1), GK(1), GK2(3), GLA(4), GLB1(2), GPAM(1), LCT(11), LIPA(1), LIPC(1), LIPF(2), LIPG(1), LPL(1), MGLL(1), PNLIP(3), PNLIPRP1(3), PNPLA3(2), PPAP2A(1), PPAP2C(2) 65416087 100 92 98 24 22 20 24 18 15 1 0.0473 1.000 1.000 378 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 38 ANAPC1(3), ANAPC10(1), ANAPC4(2), ANAPC5(5), ANAPC7(4), BTRC(2), CDC20(1), CDC23(1), CUL1(2), CUL3(2), FBXW7(6), ITCH(1), SKP2(1), SMURF1(2), SMURF2(1), TCEB1(1), UBA1(4), UBE2D2(3), UBE2D3(1), UBE2E1(1), UBE2E3(1), WWP1(2), WWP2(7) 43712872 54 50 54 11 10 18 9 9 7 1 0.0891 1.000 1.000 379 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 20 CSNK2A1(1), GRB2(1), JAK2(5), JUN(3), MAP2K1(1), MAPK3(1), MPL(1), PLCG1(6), RAF1(1), RASA1(2), SHC1(1), SOS1(4), STAT1(1), STAT3(3), STAT5A(4), STAT5B(5) 29441980 40 39 40 10 8 6 8 5 13 0 0.317 1.000 1.000 380 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(1), ATG5(2), ATG7(3), GABARAP(1), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), IFNG(2), PIK3C3(2), PIK3R4(4), PRKAA1(1), PRKAA2(3), ULK1(1), ULK2(4), ULK3(2) 23553425 40 39 40 11 3 11 16 6 4 0 0.506 1.000 1.000 381 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 AP2A1(6), AP2M1(4), ARF1(1), BTK(4), EEA1(4), GRASP(1), GSK3A(3), LYN(4), PFKL(1), PFKM(4), PFKP(2), PLCG1(6), PRKCE(2), PRKCZ(1), RPS6KB1(2), VAV2(2) 26651480 47 46 47 14 9 8 10 8 12 0 0.353 1.000 1.000 382 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 36 ACACA(4), ACAT1(2), ACYP1(1), ADH5(1), AKR1B1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DLD(1), GRHPR(1), LDHC(2), MDH2(1), ME2(2), ME3(2), PC(5), PCK1(2), PDHA1(2), PDHA2(2), PDHB(1), PKLR(3), PKM2(1) 40700821 43 37 43 10 8 14 13 5 3 0 0.113 1.000 1.000 383 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(1), ELK1(2), EPOR(4), GRB2(1), JAK2(5), JUN(3), MAP2K1(1), MAPK3(1), MAPK8(2), PLCG1(6), RAF1(1), SHC1(1), SOS1(4), STAT5A(4), STAT5B(5) 24004079 41 39 41 12 9 6 10 4 12 0 0.334 1.000 1.000 384 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 38 ARNTL(2), AZIN1(1), CBX3(3), CLOCK(1), CRY1(1), CRY2(1), EIF4G2(2), ETV6(2), G0S2(1), GSTP1(1), HSPA8(4), IDI1(2), MYF6(3), NCKAP1(6), NR1D2(1), PER1(3), PER2(3), PPP1R3C(1), PPP2CB(3), TOB1(3), TUBB3(1), UCP3(2), UGP2(1), VAPA(1), ZFR(6) 40488934 55 51 55 13 4 12 19 9 11 0 0.350 1.000 1.000 385 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 40 ALDH1A3(3), ALDH1B1(1), ALDH3B2(2), ALDH9A1(1), AMDHD1(3), AOC2(1), AOC3(3), ASPA(2), CARM1(2), CNDP1(3), DDC(1), FTCD(1), HAL(2), HARS(1), HEMK1(1), LCMT1(1), LCMT2(5), MAOA(2), MAOB(1), METTL2B(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), PRPS2(1), UROC1(2), WBSCR22(2) 42772465 55 48 55 14 9 15 20 3 8 0 0.125 1.000 1.000 386 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(4), COL4A2(5), COL4A3(2), COL4A4(5), COL4A5(6), COL4A6(7), F2(4), F2R(3), F5(14), F8(7), F9(1), FGA(5), FGB(1), FGG(4), KLKB1(1), PROC(1), PROS1(1), SERPINC1(4), SERPING1(2) 50584894 77 72 77 20 10 15 30 12 10 0 0.319 1.000 1.000 387 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 41 ACACA(4), ACACB(9), ACAT1(2), ACYP1(1), AKR1B1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DLD(1), GRHPR(1), LDHC(2), MDH2(1), ME2(2), ME3(2), PC(5), PCK1(2), PCK2(3), PDHA1(2), PDHA2(2), PDHB(1), PKLR(3), PKM2(1) 51688159 51 46 51 10 9 12 17 9 4 0 0.0538 1.000 1.000 388 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(1), INPP4A(4), INPP4B(5), INPP5A(2), INPPL1(4), ITPKA(1), ITPKB(7), OCRL(6), PIK3C2A(4), PIK3C2B(6), PIK3C2G(3), PIK3CB(6), PIK3CG(3), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PLCD1(1), PLCG1(6), PLCG2(3) 47771228 78 75 78 19 13 16 22 14 13 0 0.126 1.000 1.000 389 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 32 ATF2(2), DLD(1), DUSP10(2), DUSP4(1), GAB1(2), GCK(2), IL1R1(1), JUN(3), MAP2K5(2), MAP2K7(1), MAP3K10(4), MAP3K11(1), MAP3K12(2), MAP3K13(7), MAP3K5(2), MAP3K7(1), MAP3K9(4), MAPK10(2), MAPK8(2), MYEF2(3), NFATC3(4), NR2C2(2), PAPPA(9), SHC1(1), TRAF6(3), ZAK(2) 45270315 66 60 66 16 15 10 14 9 18 0 0.233 1.000 1.000 390 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP5(2), ACPP(5), ACPT(2), ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), CYP1A2(3), CYP2A13(4), CYP2A6(1), CYP2A7(1), CYP2B6(4), CYP2C18(2), CYP2C19(1), CYP2C8(3), CYP2C9(2), CYP2D6(1), CYP2E1(1), CYP2F1(1), CYP3A4(3), CYP3A7(4), CYP4B1(3), CYP4F8(4), PON1(1) 32341955 56 47 53 16 11 8 21 9 7 0 0.323 1.000 1.000 391 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 187 ACTB(2), ACTG1(4), ACTN1(1), ACTN2(9), ACTN3(1), ACTN4(6), AKT2(3), AKT3(4), ARHGAP5(3), BCAR1(2), BIRC3(1), BRAF(3), CAPN2(3), CAV1(2), CCND1(1), CCND3(2), COL11A1(4), COL11A2(1), COL1A1(8), COL1A2(6), COL2A1(5), COL3A1(1), COL4A1(4), COL4A2(5), COL4A4(5), COL4A6(7), COL5A1(5), COL5A2(6), COL5A3(7), COL6A1(1), COL6A2(2), COL6A3(10), COL6A6(10), COMP(5), CRK(1), CRKL(1), CTNNB1(1), DIAPH1(4), EGF(3), EGFR(5), ELK1(2), FARP2(5), FIGF(2), FLNA(5), FLNB(13), FLNC(10), FLT1(2), FN1(5), GRB2(1), GRLF1(7), HGF(4), IBSP(2), IGF1(1), IGF1R(2), ILK(2), ITGA1(5), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(2), ITGA5(2), ITGA6(4), ITGA7(5), ITGA8(3), ITGA9(2), ITGAV(6), ITGB1(3), ITGB3(3), ITGB4(4), ITGB5(2), ITGB6(2), ITGB8(2), JUN(3), KDR(2), LAMA1(9), LAMA2(10), LAMA3(8), LAMA4(6), LAMA5(7), LAMB1(7), LAMB2(7), LAMB3(5), LAMB4(10), LAMC1(8), LAMC2(2), LAMC3(2), MAP2K1(1), MAPK1(1), MAPK10(2), MAPK3(1), MAPK8(2), MET(7), MYL5(1), MYLK(8), MYLK2(2), MYLPF(1), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PARVA(1), PDGFB(2), PDGFRA(3), PDGFRB(3), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PIP5K1C(4), PPP1R12A(3), PRKCG(2), PTK2(5), RAF1(1), RAPGEF1(4), RELN(19), RHOA(2), ROCK1(4), ROCK2(4), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(4), SOS2(4), SPP1(2), THBS1(4), THBS2(1), THBS3(3), THBS4(2), TLN1(12), TLN2(5), TNC(6), TNN(6), TNR(6), TNXB(9), VAV1(4), VAV2(2), VAV3(4), VCL(4), VTN(1), VWF(10) 397797112 562 344 560 193 108 115 157 83 99 0 0.662 1.000 1.000 392 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 165 ADCY1(3), ADCY3(3), ADCY4(2), ADCY7(7), ADCY8(7), ADCY9(9), ADORA2A(2), ADRA1A(2), ADRA1B(1), ADRB2(1), ATP2A1(5), ATP2A2(1), ATP2A3(1), ATP2B1(5), ATP2B2(4), ATP2B3(10), ATP2B4(3), AVPR1B(2), BDKRB1(2), BDKRB2(1), CACNA1A(13), CACNA1B(9), CACNA1C(10), CACNA1D(7), CACNA1E(17), CACNA1F(11), CACNA1G(6), CACNA1H(5), CACNA1I(2), CACNA1S(5), CAMK2A(2), CAMK2D(4), CAMK2G(1), CAMK4(3), CCKAR(1), CCKBR(1), CD38(3), CHRM1(2), CHRM2(4), CHRM3(1), CHRM5(2), CYSLTR1(2), CYSLTR2(2), EDNRA(1), EDNRB(2), EGFR(5), ERBB3(11), ERBB4(6), F2R(3), GNA14(1), GNAQ(1), GNAS(5), GRIN1(1), GRIN2A(12), GRIN2C(4), GRIN2D(4), GRM1(5), GRM5(2), GRPR(1), HRH1(2), HRH2(2), HTR2A(3), HTR2B(1), HTR2C(2), HTR5A(5), ITPKA(1), ITPKB(7), ITPR1(10), ITPR2(7), ITPR3(6), LHCGR(5), LTB4R2(1), MYLK(8), MYLK2(2), NOS1(7), NOS3(3), P2RX2(3), P2RX3(1), P2RX4(2), P2RX5(2), PDE1A(2), PDE1B(2), PDE1C(2), PDGFRA(3), PDGFRB(3), PHKA1(4), PHKA2(9), PHKB(2), PHKG2(2), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PLCD1(1), PLCD3(3), PLCD4(1), PLCE1(12), PLCG1(6), PLCG2(3), PLCZ1(8), PLN(1), PPID(2), PPP3CA(4), PPP3CB(3), PPP3R1(1), PRKACA(2), PRKACG(1), PRKCG(2), PRKX(2), PTGER3(3), PTGFR(1), PTK2B(3), RYR1(16), RYR2(32), RYR3(24), SLC25A4(1), SLC8A1(3), SLC8A3(1), SPHK2(2), TACR1(1), TACR2(2), TACR3(1), TNNC2(1), TRPC1(3), VDAC2(2) 299646922 521 332 518 189 129 73 160 106 52 1 0.472 1.000 1.000 393 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 237 ACVR1B(6), ACVR1C(2), AKT2(3), AKT3(4), ARRB1(1), ARRB2(1), ATF2(2), ATF4(2), BDNF(1), BRAF(3), CACNA1A(13), CACNA1B(9), CACNA1C(10), CACNA1D(7), CACNA1E(17), CACNA1F(11), CACNA1G(6), CACNA1H(5), CACNA1I(2), CACNA1S(5), CACNA2D1(5), CACNA2D2(4), CACNA2D3(5), CACNA2D4(2), CACNB1(2), CACNB2(3), CACNB3(1), CACNG1(1), CACNG2(1), CACNG3(3), CACNG4(2), CACNG5(1), CACNG6(1), CACNG7(1), CD14(2), CDC25B(3), CHUK(1), CRK(1), CRKL(1), DAXX(2), DUSP10(2), DUSP16(5), DUSP4(1), DUSP6(1), DUSP7(1), DUSP9(1), EGF(3), EGFR(5), ELK1(2), FAS(1), FASLG(2), FGF10(1), FGF11(1), FGF13(3), FGF18(1), FGF23(2), FGF3(1), FGF6(1), FGF7(2), FGF9(1), FGFR3(2), FGFR4(4), FLNA(5), FLNB(13), FLNC(10), GRB2(1), IKBKB(4), IL1A(1), IL1R1(1), IL1R2(5), JUN(3), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K5(2), MAP2K6(1), MAP2K7(1), MAP3K10(4), MAP3K12(2), MAP3K13(7), MAP3K5(2), MAP3K6(3), MAP3K7(1), MAP3K8(2), MAP4K1(4), MAP4K3(2), MAP4K4(4), MAPK1(1), MAPK10(2), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), MAPKAPK2(1), MAPKAPK3(1), MAPT(3), MAX(3), MEF2C(3), MOS(3), MYC(1), NF1(20), NFATC2(2), NFATC4(5), NFKB1(4), NFKB2(3), NLK(2), NR4A1(2), NRAS(1), NTRK1(4), NTRK2(6), PAK1(2), PAK2(2), PDGFB(2), PDGFRA(3), PDGFRB(3), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PPM1A(1), PPM1B(3), PPP3CA(4), PPP3CB(3), PPP3R1(1), PPP5C(1), PRKACA(2), PRKACG(1), PRKCG(2), PRKX(2), PTPN5(3), PTPN7(2), PTPRR(2), RAF1(1), RAPGEF2(3), RASA1(2), RASA2(2), RASGRF1(4), RASGRF2(2), RASGRP2(2), RASGRP3(1), RASGRP4(1), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KA4(1), RPS6KA5(4), RPS6KA6(3), SOS1(4), SOS2(4), SRF(1), STK3(1), STK4(3), TAOK1(5), TAOK2(1), TAOK3(4), TGFB1(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TNFRSF1A(1), TRAF6(3), ZAK(2) 307227564 484 304 484 163 105 82 133 75 87 2 0.388 1.000 1.000 394 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 195 ABI2(1), ACTN1(1), ACTN2(9), ACTN3(1), ACTN4(6), APC(5), ARAF(4), ARHGEF1(7), ARHGEF12(2), ARHGEF4(4), ARHGEF6(4), ARHGEF7(2), ARPC1A(1), ARPC1B(2), ARPC2(2), BCAR1(2), BDKRB1(2), BDKRB2(1), BRAF(3), C3orf10(1), CD14(2), CHRM1(2), CHRM2(4), CHRM3(1), CHRM5(2), CRK(1), CRKL(1), CYFIP1(2), CYFIP2(7), DIAPH1(4), DIAPH2(4), DIAPH3(3), EGF(3), EGFR(5), EZR(3), F2(4), F2R(3), FGD3(3), FGF10(1), FGF11(1), FGF13(3), FGF18(1), FGF23(2), FGF3(1), FGF6(1), FGF7(2), FGF9(1), FGFR3(2), FGFR4(4), FN1(5), GIT1(1), GRLF1(7), GSN(1), IQGAP1(2), IQGAP2(4), IQGAP3(6), ITGA1(5), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(2), ITGA5(2), ITGA6(4), ITGA7(5), ITGA8(3), ITGA9(2), ITGAD(3), ITGAE(1), ITGAL(1), ITGAM(3), ITGAV(6), ITGAX(5), ITGB1(3), ITGB2(4), ITGB3(3), ITGB4(4), ITGB5(2), ITGB6(2), ITGB8(2), LIMK1(4), LIMK2(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MOS(3), MSN(2), MYH10(7), MYH14(11), MYH9(8), MYL5(1), MYLK(8), MYLK2(2), MYLPF(1), NCKAP1(6), NCKAP1L(5), NRAS(1), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PDGFB(2), PDGFRA(3), PDGFRB(3), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PIP4K2A(1), PIP4K2C(6), PIP5K1A(2), PIP5K1B(1), PIP5K1C(4), PPP1R12A(3), PPP1R12B(1), PTK2(5), RAF1(1), RDX(1), RHOA(2), ROCK1(4), ROCK2(4), SCIN(1), SLC9A1(1), SOS1(4), SOS2(4), SSH1(1), SSH2(1), SSH3(2), TIAM1(1), TIAM2(5), VAV1(4), VAV2(2), VAV3(4), VCL(4), WAS(3), WASF1(5), WASL(1) 302530596 409 287 408 153 80 74 112 75 68 0 0.907 1.000 1.000 395 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 134 ACTB(2), ACTG1(4), COL11A1(4), COL11A2(1), COL17A1(5), COL1A1(8), COL1A2(6), COL2A1(5), COL3A1(1), COL4A1(4), COL4A2(5), COL4A4(5), COL4A6(7), COL5A1(5), COL5A2(6), COL5A3(7), COL6A1(1), COL6A2(2), COL6A3(10), COL6A6(10), COMP(5), DSC1(2), DSC2(5), DSC3(1), DSG1(3), DSG2(1), DSG3(5), DSG4(4), FN1(5), GJA1(2), GJA10(1), GJA4(1), GJA5(3), GJA8(1), GJA9(1), GJB2(1), GJB3(2), GJB4(1), GJB5(2), GJB6(1), GJC1(1), GJD4(1), IBSP(2), INA(1), ITGA6(4), ITGB4(4), KRT1(6), KRT14(2), KRT15(1), KRT17(4), KRT18(1), KRT19(3), KRT2(2), KRT20(1), KRT24(1), KRT25(1), KRT28(5), KRT3(1), KRT31(1), KRT32(1), KRT33A(1), KRT34(2), KRT35(1), KRT36(2), KRT39(1), KRT4(2), KRT6A(1), KRT6B(1), KRT6C(1), KRT7(2), KRT71(1), KRT72(2), KRT73(2), KRT74(1), KRT76(3), KRT78(1), KRT79(2), KRT81(2), KRT82(2), KRT84(4), KRT85(1), KRT86(2), KRT9(3), LAMA1(9), LAMA2(10), LAMA3(8), LAMA4(6), LAMA5(7), LAMB1(7), LAMB2(7), LAMB3(5), LAMB4(10), LAMC1(8), LAMC2(2), LAMC3(2), LMNA(1), LMNB1(1), NES(4), RELN(19), SPP1(2), THBS1(4), THBS2(1), THBS3(3), THBS4(2), TNC(6), TNN(6), TNR(6), TNXB(9), VIM(1), VTN(1), VWF(10) 270635939 385 278 384 133 78 81 113 49 64 0 0.531 1.000 1.000 396 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 230 ADCYAP1R1(1), ADORA1(1), ADORA2A(2), ADORA3(2), ADRA1A(2), ADRA1B(1), ADRA2B(3), ADRB2(1), AVPR1B(2), AVPR2(3), BDKRB1(2), BDKRB2(1), BRS3(3), C3AR1(2), C5AR1(1), CALCR(1), CALCRL(2), CCKAR(1), CCKBR(1), CHRM1(2), CHRM2(4), CHRM3(1), CHRM5(2), CNR1(2), CNR2(1), CRHR1(2), CRHR2(1), CTSG(1), CYSLTR1(2), CYSLTR2(2), DRD2(2), DRD3(1), DRD5(2), EDNRA(1), EDNRB(2), F2(4), F2R(3), F2RL2(1), FPR1(1), FSHR(4), GABBR1(1), GABBR2(2), GABRA1(1), GABRA2(1), GABRA3(3), GABRA4(1), GABRA5(2), GABRA6(3), GABRB1(1), GABRB2(2), GABRB3(1), GABRE(1), GABRG1(2), GABRG2(3), GABRG3(3), GABRP(1), GABRQ(3), GABRR1(1), GALR1(2), GALR2(2), GH1(1), GH2(4), GHR(2), GHRHR(2), GHSR(1), GIPR(1), GLP2R(2), GLRA2(1), GLRA3(3), GPR156(3), GPR35(1), GPR50(2), GPR63(1), GPR83(4), GRIA1(8), GRIA2(3), GRIA3(10), GRIA4(5), GRID1(8), GRID2(6), GRIK1(6), GRIK2(9), GRIK3(4), GRIK4(1), GRIK5(5), GRIN1(1), GRIN2A(12), GRIN2B(9), GRIN2C(4), GRIN2D(4), GRIN3A(4), GRM1(5), GRM2(3), GRM3(8), GRM4(1), GRM5(2), GRM6(3), GRM7(3), GRM8(3), GRPR(1), GZMA(2), HCRTR1(2), HCRTR2(3), HRH1(2), HRH2(2), HRH3(2), HRH4(1), HTR1A(4), HTR1B(1), HTR1E(3), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(2), HTR5A(5), LEPR(4), LHCGR(5), LTB4R2(1), MAS1(2), MC2R(2), MC3R(2), MC4R(2), MCHR2(2), NMBR(2), NMUR1(1), NMUR2(2), NPBWR1(1), NPFFR2(4), NPY1R(4), NPY2R(1), NR3C1(2), NTSR2(1), OPRD1(2), OPRK1(2), OPRL1(2), OPRM1(5), P2RX2(3), P2RX3(1), P2RX4(2), P2RX5(2), P2RY1(3), P2RY10(2), P2RY11(1), P2RY13(3), P2RY2(1), P2RY4(2), P2RY6(1), P2RY8(2), PARD3(4), PPYR1(1), PRLR(1), PRSS3(1), PTGDR(1), PTGER3(3), PTGFR(1), PTH2R(2), RXFP1(3), RXFP2(1), SSTR2(1), SSTR3(2), SSTR5(1), TAAR1(1), TAAR2(1), TAAR5(3), TAAR6(2), TACR1(1), TACR2(2), TACR3(1), THRA(1), THRB(1), TSHR(4), VIPR2(1) 237322171 412 276 412 145 103 56 141 68 43 1 0.250 1.000 1.000 397 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(7), ADCY6(1), ADCY7(7), ADCY8(7), ADCY9(9), ADRA1A(2), ADRA1B(1), ADRB2(1), ANXA6(4), ARRB1(1), ARRB2(1), ATP1A4(11), ATP1B1(2), ATP1B3(1), ATP2A2(1), ATP2A3(1), ATP2B1(5), ATP2B2(4), ATP2B3(10), CACNA1A(13), CACNA1B(9), CACNA1C(10), CACNA1D(7), CACNA1E(17), CACNA1S(5), CACNB1(2), CACNB3(1), CALR(1), CAMK1(2), CAMK2A(2), CAMK2D(4), CAMK2G(1), CAMK4(3), CASQ1(2), CASQ2(2), CHRM1(2), CHRM2(4), CHRM3(1), CHRM5(2), GJA1(2), GJA4(1), GJA5(3), GJB2(1), GJB3(2), GJB4(1), GJB5(2), GJB6(1), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNB1(1), GNB2(1), GNB3(3), GRK4(2), GRK6(1), ITPR1(10), ITPR2(7), ITPR3(6), KCNB1(4), KCNJ3(1), KCNJ5(1), MIB1(4), NME7(4), PKIG(1), PLCB3(3), PLN(1), PRKACA(2), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(6), PRKCZ(1), PRKD1(2), RGS1(1), RGS10(1), RGS11(1), RGS14(1), RGS16(3), RGS17(2), RGS20(2), RGS3(7), RGS4(4), RGS5(1), RGS7(8), RGS9(4), RYR1(16), RYR2(32), RYR3(24), SLC8A1(3), SLC8A3(1), USP5(4), YWHAB(1) 214030558 383 274 383 143 100 53 110 76 43 1 0.523 1.000 1.000 398 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 126 ACTB(2), ACTG1(4), ACTN1(1), ACTN2(9), ACTN3(1), ACTN4(6), AKT2(3), AKT3(4), AMOTL1(4), ASH1L(10), CASK(6), CDK4(1), CGN(3), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(1), CLDN17(2), CLDN19(1), CLDN22(2), CLDN6(1), CRB3(1), CSNK2A1(1), CSNK2A2(1), CTNNA1(4), CTNNA2(8), CTNNA3(6), CTNNB1(1), CTTN(1), EPB41(3), EPB41L1(4), EPB41L2(2), EPB41L3(4), EXOC3(3), EXOC4(2), F11R(2), GNAI1(1), GNAI2(2), GNAI3(1), HCLS1(1), IGSF5(2), INADL(6), JAM3(1), LLGL1(1), LLGL2(4), MAGI1(10), MAGI2(9), MAGI3(4), MLLT4(12), MPDZ(6), MPP5(2), MYH1(8), MYH10(7), MYH11(10), MYH13(7), MYH14(11), MYH15(6), MYH2(3), MYH3(2), MYH4(6), MYH6(12), MYH7(10), MYH7B(11), MYH8(13), MYH9(8), MYL5(1), MYLPF(1), NRAS(1), PARD3(4), PARD6B(2), PPP2CA(2), PPP2CB(3), PPP2R1A(1), PPP2R2A(1), PPP2R3A(3), PPP2R4(4), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(6), PRKCZ(1), RAB13(1), RHOA(2), SPTAN1(4), SYMPK(5), TJP1(6), TJP2(1), TJP3(2), VAPA(1), YES1(2), ZAK(2) 215541664 347 254 341 114 72 50 106 53 65 1 0.620 1.000 1.000 399 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(1), CD36(1), CD44(2), COL11A1(4), COL11A2(1), COL1A1(8), COL1A2(6), COL2A1(5), COL3A1(1), COL4A1(4), COL4A2(5), COL4A4(5), COL4A6(7), COL5A1(5), COL5A2(6), COL5A3(7), COL6A1(1), COL6A2(2), COL6A3(10), COL6A6(10), DAG1(1), FN1(5), FNDC1(9), FNDC3A(1), FNDC4(1), GP6(2), HMMR(1), HSPG2(8), IBSP(2), ITGA1(5), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(2), ITGA5(2), ITGA6(4), ITGA7(5), ITGA8(3), ITGA9(2), ITGAV(6), ITGB1(3), ITGB3(3), ITGB4(4), ITGB5(2), ITGB6(2), ITGB8(2), LAMA1(9), LAMA2(10), LAMA3(8), LAMA4(6), LAMA5(7), LAMB1(7), LAMB2(7), LAMB3(5), LAMB4(10), LAMC1(8), LAMC2(2), LAMC3(2), RELN(19), SDC2(2), SPP1(2), SV2A(3), SV2B(1), THBS1(4), THBS2(1), THBS3(3), THBS4(2), TNC(6), TNN(6), TNR(6), TNXB(9), VTN(1), VWF(10) 243632272 334 247 333 125 64 73 96 45 56 0 0.841 1.000 1.000 400 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 136 ACTA1(2), ACTA2(2), ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(7), ADCY6(1), ADCY7(7), ADCY8(7), ADCY9(9), ARRB1(1), ARRB2(1), ATF1(2), ATF2(2), ATF3(1), ATF4(2), ATP2A2(1), ATP2A3(1), CACNB3(1), CALCA(1), CAMK2A(2), CAMK2D(4), CAMK2G(1), CNN1(1), CNN2(1), CORIN(2), CREB3(1), CRHR1(2), ETS2(5), GABPA(1), GJA1(2), GNAQ(1), GNB1(1), GNB2(1), GNB3(3), GRK4(2), GRK6(1), GUCY1A3(1), IGFBP2(1), IGFBP3(1), IGFBP4(1), IL6(2), ITPR1(10), ITPR2(7), ITPR3(6), JUN(3), MIB1(4), MYLK2(2), NFKB1(4), NOS1(7), NOS3(3), PDE4B(4), PDE4D(6), PKIG(1), PLCB3(3), PLCD1(1), PLCG1(6), PLCG2(3), PRKACA(2), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCH(1), PRKCQ(6), PRKCZ(1), PRKD1(2), RAMP3(1), RGS1(1), RGS10(1), RGS11(1), RGS14(1), RGS16(3), RGS17(2), RGS20(2), RGS3(7), RGS4(4), RGS5(1), RGS7(8), RGS9(4), RLN1(1), RYR1(16), RYR2(32), RYR3(24), SLC8A1(3), SP1(3), TNXB(9), USP5(4), YWHAB(1) 191245200 314 245 314 114 76 40 93 61 44 0 0.571 1.000 1.000 401 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 247 ACVR1(1), ACVR1B(6), ACVR2A(4), ACVR2B(1), AMHR2(3), BMP2(3), BMPR1B(3), BMPR2(3), CCL11(1), CCL13(2), CCL14(1), CCL20(1), CCL21(1), CCL23(1), CCL28(1), CCL7(1), CCR1(1), CCR2(5), CCR3(1), CCR5(2), CCR7(3), CD40(1), CD40LG(1), CLCF1(1), CNTFR(1), CSF1(3), CSF2RA(2), CSF2RB(3), CSF3R(3), CX3CL1(2), CX3CR1(3), CXCL6(1), CXCR3(5), EDA(2), EDA2R(1), EDAR(2), EGF(3), EGFR(5), EPOR(4), FAS(1), FASLG(2), FLT1(2), FLT3(3), FLT3LG(2), FLT4(1), GH1(1), GH2(4), GHR(2), HGF(4), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), IFNAR1(1), IFNAR2(1), IFNB1(1), IFNG(2), IFNK(1), IL10RA(2), IL10RB(4), IL11(1), IL11RA(4), IL12A(1), IL12B(1), IL12RB1(4), IL12RB2(1), IL13RA1(1), IL15(2), IL17B(2), IL17RA(2), IL17RB(2), IL18(1), IL18R1(2), IL18RAP(3), IL19(1), IL1A(1), IL1R1(1), IL1R2(5), IL1RAP(7), IL2(1), IL20(1), IL20RA(1), IL21(1), IL21R(1), IL22(1), IL22RA1(2), IL22RA2(1), IL23R(3), IL25(1), IL28A(1), IL28B(3), IL28RA(1), IL2RB(1), IL2RG(1), IL3RA(2), IL4R(4), IL5RA(2), IL6(2), IL6R(1), IL6ST(6), IL7R(4), IL9R(2), INHBA(3), INHBB(1), INHBC(1), INHBE(1), KDR(2), KIT(5), KITLG(3), LEPR(4), LIF(3), LIFR(7), LTA(1), MET(7), MPL(1), NGFR(1), OSMR(4), PDGFB(2), PDGFRA(3), PDGFRB(3), PF4(1), PLEKHO2(1), PRLR(1), TGFB1(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TNFRSF10D(1), TNFRSF11A(2), TNFRSF11B(4), TNFRSF19(2), TNFRSF1A(1), TNFRSF21(2), TNFRSF25(1), TNFRSF8(2), TNFRSF9(2), TNFSF13B(1), TNFSF14(1), TNFSF18(1), TNFSF4(3), TPO(5), TSLP(1), XCL1(2), XCR1(4) 197085524 319 243 316 87 59 62 90 49 59 0 0.0160 1.000 1.000 402 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 125 ABL1(5), ABLIM1(4), ABLIM3(2), ARHGEF12(2), CDK5(1), DCC(10), DPYSL2(2), DPYSL5(2), EFNA3(1), EFNB1(1), EFNB2(2), EPHA1(3), EPHA2(3), EPHA3(4), EPHA4(2), EPHA5(7), EPHA6(3), EPHA7(3), EPHA8(1), EPHB1(5), EPHB2(3), EPHB3(3), EPHB4(2), EPHB6(3), FES(2), GNAI1(1), GNAI2(2), GNAI3(1), ITGB1(3), L1CAM(4), LIMK1(4), LIMK2(2), LRRC4C(3), MAPK1(1), MAPK3(1), MET(7), NCK1(1), NCK2(1), NFAT5(6), NFATC2(2), NFATC3(4), NFATC4(5), NGEF(2), NRAS(1), NRP1(6), NTNG1(2), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PLXNA1(7), PLXNA2(5), PLXNA3(6), PLXNB1(2), PLXNB2(3), PLXNB3(4), PLXNC1(2), PPP3CA(4), PPP3CB(3), PPP3R1(1), PTK2(5), RASA1(2), RGS3(7), RHOA(2), RND1(1), ROBO1(8), ROBO2(7), ROBO3(1), ROCK1(4), ROCK2(4), SEMA3A(5), SEMA3B(1), SEMA3C(3), SEMA3D(2), SEMA3E(1), SEMA3F(1), SEMA4A(4), SEMA4C(1), SEMA4D(3), SEMA4F(6), SEMA4G(3), SEMA5A(8), SEMA5B(6), SEMA6A(4), SEMA6C(1), SEMA6D(2), SEMA7A(2), SLIT1(1), SLIT2(6), SLIT3(3), SRGAP1(8), SRGAP2(5), SRGAP3(1), UNC5B(3), UNC5C(5), UNC5D(10) 210469091 318 241 318 91 62 63 100 42 51 0 0.0709 1.000 1.000 403 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(2), ACTA2(2), ACTN2(9), ACTN3(1), ACTN4(6), DMD(28), FAM48A(1), MYBPC1(3), MYBPC2(4), MYBPC3(2), MYH3(2), MYH6(12), MYH7(10), MYH8(13), MYL1(1), MYOM1(4), NEB(25), TMOD1(1), TNNC2(1), TNNI3(1), TNNT1(1), TNNT3(2), TPM1(3), TPM2(3), TPM3(3), TPM4(1), TTN(155), VIM(1) 162286787 297 220 295 55 47 41 101 67 40 1 0.000727 1.000 1.000 404 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 148 AKT2(3), AKT3(4), CBL(4), CBLB(10), CBLC(2), CCND1(1), CCND3(2), CISH(1), CLCF1(1), CNTFR(1), CREBBP(7), CSF2RA(2), CSF2RB(3), CSF3R(3), EP300(7), EPOR(4), GH1(1), GH2(4), GHR(2), GRB2(1), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), IFNAR1(1), IFNAR2(1), IFNB1(1), IFNG(2), IFNK(1), IL10RA(2), IL10RB(4), IL11(1), IL11RA(4), IL12A(1), IL12B(1), IL12RB1(4), IL12RB2(1), IL13RA1(1), IL13RA2(4), IL15(2), IL19(1), IL2(1), IL20(1), IL20RA(1), IL21(1), IL21R(1), IL22(1), IL22RA1(2), IL22RA2(1), IL23R(3), IL28A(1), IL28B(3), IL28RA(1), IL2RB(1), IL2RG(1), IL3RA(2), IL4R(4), IL5RA(2), IL6(2), IL6R(1), IL6ST(6), IL7R(4), IL9R(2), IRF9(3), JAK1(4), JAK2(5), JAK3(5), LEPR(4), LIF(3), LIFR(7), MPL(1), MYC(1), OSMR(4), PIAS1(2), PIAS2(4), PIAS4(2), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PRLR(1), PTPN11(1), SOCS4(2), SOCS5(1), SOS1(4), SOS2(4), SPRED1(3), SPRED2(1), SPRY1(1), SPRY2(1), SPRY3(3), STAM(2), STAM2(2), STAT1(1), STAT2(2), STAT3(3), STAT4(6), STAT5A(4), STAT5B(5), STAT6(2), TPO(5), TSLP(1), TYK2(5) 156790250 271 206 269 59 46 48 79 43 55 0 0.00240 1.000 1.000 405 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 124 ACACA(4), ACACB(9), AKT2(3), AKT3(4), ARAF(4), BRAF(3), CBL(4), CBLB(10), CBLC(2), CRK(1), CRKL(1), ELK1(2), EXOC7(2), FASN(8), FLOT1(1), FLOT2(2), G6PC(1), G6PC2(2), GCK(2), GRB2(1), GYS1(5), GYS2(1), IKBKB(4), INPP5D(4), INSR(4), IRS1(2), IRS4(6), LIPE(3), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK10(2), MAPK3(1), MAPK8(2), NRAS(1), PCK1(2), PCK2(3), PDE3A(8), PDE3B(2), PFKL(1), PFKM(4), PFKP(2), PHKA1(4), PHKA2(9), PHKB(2), PHKG2(2), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PKLR(3), PKM2(1), PPARGC1A(5), PPP1R3A(8), PPP1R3B(2), PPP1R3C(1), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKACA(2), PRKACG(1), PRKAG2(1), PRKAG3(3), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PRKCI(1), PRKCZ(1), PRKX(2), PTPRF(6), PYGB(3), PYGL(2), PYGM(5), RAF1(1), RAPGEF1(4), RHEB(1), RPS6(2), RPS6KB1(2), RPS6KB2(4), SH2B2(1), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SLC2A4(1), SOCS4(2), SORBS1(5), SOS1(4), SOS2(4), SREBF1(1), TRIP10(5), TSC1(4), TSC2(2) 166594639 264 205 264 86 51 51 69 46 47 0 0.438 1.000 1.000 406 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 140 ADA(2), ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(7), ADCY6(1), ADCY7(7), ADCY8(7), ADCY9(9), ADK(1), ADSL(2), AK2(1), AK3L1(1), AK5(2), AK7(2), AMPD1(6), AMPD2(1), AMPD3(1), ATIC(3), CANT1(1), DGUOK(2), ENPP1(5), ENPP3(2), ENTPD1(2), ENTPD2(2), ENTPD4(3), ENTPD5(1), ENTPD6(2), FHIT(1), GART(1), GDA(1), GMPR2(1), GMPS(2), GUCY1A2(5), GUCY1A3(1), GUCY1B3(2), GUCY2C(6), GUCY2D(2), GUCY2F(4), IMPDH1(2), IMPDH2(1), NME4(1), NME6(1), NME7(4), NPR1(3), NPR2(2), NT5C1B(4), NT5C3(1), NT5E(5), NT5M(1), NUDT2(1), NUDT5(1), NUDT9(1), PAICS(1), PAPSS1(2), PDE10A(6), PDE11A(4), PDE1A(2), PDE1C(2), PDE2A(4), PDE3B(2), PDE4A(1), PDE4B(4), PDE4C(5), PDE4D(6), PDE5A(1), PDE7B(1), PDE8A(1), PDE9A(5), PFAS(1), PKLR(3), PKM2(1), PNPT1(3), POLA1(5), POLD1(1), POLD2(1), POLD4(1), POLE(7), POLE2(1), POLE3(1), POLR1A(6), POLR1B(2), POLR1C(2), POLR1D(4), POLR2A(5), POLR2B(7), POLR2C(1), POLR2F(2), POLR2H(1), POLR2J(2), POLR3A(2), POLR3B(2), POLR3GL(3), PPAT(1), PRPS2(1), PRUNE(4), RRM1(2), RRM2(1), XDH(4) 182345593 259 200 255 86 50 37 85 48 39 0 0.575 1.000 1.000 407 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 122 ALCAM(4), CADM1(3), CADM3(1), CD2(3), CD22(1), CD226(3), CD274(1), CD28(1), CD34(2), CD4(4), CD40(1), CD40LG(1), CD58(1), CD86(2), CD8A(2), CD99(2), CDH15(3), CDH2(1), CDH3(1), CDH4(3), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(1), CLDN17(2), CLDN19(1), CLDN22(2), CLDN6(1), CNTN1(7), CNTN2(4), CNTNAP1(4), CNTNAP2(6), CTLA4(1), ESAM(2), F11R(2), GLG1(4), HLA-C(2), HLA-DMA(1), HLA-DMB(2), HLA-E(1), HLA-F(4), HLA-G(2), ICAM1(1), ICAM3(2), ICOS(1), ICOSLG(2), ITGA4(2), ITGA6(4), ITGA8(3), ITGA9(2), ITGAL(1), ITGAM(3), ITGAV(6), ITGB1(3), ITGB2(4), ITGB8(2), JAM3(1), L1CAM(4), MAG(2), MPZL1(1), NCAM1(4), NCAM2(3), NEGR1(1), NEO1(5), NFASC(6), NLGN1(2), NLGN2(3), NLGN3(5), NRCAM(3), NRXN1(6), NRXN2(10), NRXN3(7), PDCD1(1), PTPRC(3), PTPRF(6), PTPRM(3), PVRL1(2), PVRL2(3), PVRL3(4), SDC2(2), SELE(1), SELL(5), SELP(8), SELPLG(7), SIGLEC1(2), SPN(2), VCAM1(4), VCAN(12) 154206640 256 189 248 73 45 49 67 41 54 0 0.101 1.000 1.000 408 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 70 CDS1(3), CDS2(2), DGKA(3), DGKB(4), DGKD(3), DGKE(2), DGKG(6), DGKH(1), DGKI(7), DGKQ(1), FN3K(1), IMPA1(1), INPP4A(4), INPP4B(5), INPP5A(2), INPP5B(5), INPP5D(4), INPPL1(4), ITGB1BP3(1), ITPK1(1), ITPKA(1), ITPKB(7), ITPR1(10), ITPR2(7), ITPR3(6), OCRL(6), PI4KA(5), PI4KB(1), PIK3C2A(4), PIK3C2B(6), PIK3C2G(3), PIK3C3(2), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PIP4K2A(1), PIP4K2C(6), PIP5K1A(2), PIP5K1B(1), PIP5K1C(4), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PLCD1(1), PLCD3(3), PLCD4(1), PLCE1(12), PLCG1(6), PLCG2(3), PLCZ1(8), PRKCG(2), SYNJ1(2), SYNJ2(1) 134579316 202 175 197 64 35 34 55 41 37 0 0.453 1.000 1.000 409 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 138 APC(5), AXIN1(1), AXIN2(1), BTRC(2), CAMK2A(2), CAMK2D(4), CAMK2G(1), CCND1(1), CCND3(2), CER1(1), CHD8(3), CREBBP(7), CSNK1A1(1), CSNK1A1L(3), CSNK1E(2), CSNK2A1(1), CSNK2A2(1), CTNNB1(1), CUL1(2), DAAM1(3), DAAM2(3), DKK2(1), DKK4(1), DVL1(2), DVL3(2), EP300(7), FZD1(1), FZD2(1), FZD3(3), FZD6(3), FZD7(1), FZD8(2), FZD9(3), JUN(3), LRP5(1), LRP6(3), MAP3K7(1), MAPK10(2), MAPK8(2), MYC(1), NFAT5(6), NFATC2(2), NFATC3(4), NFATC4(5), NKD1(1), NKD2(1), NLK(2), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PORCN(1), PPP2CA(2), PPP2CB(3), PPP2R1A(1), PPP2R2A(1), PPP3CA(4), PPP3CB(3), PPP3R1(1), PRICKLE1(2), PRICKLE2(3), PRKACA(2), PRKACG(1), PRKCG(2), PRKX(2), PSEN1(1), RHOA(2), ROCK1(4), ROCK2(4), RUVBL1(1), SFRP1(2), SFRP4(2), SIAH1(3), SMAD2(4), SMAD3(3), SMAD4(3), TBL1X(4), TCF7(3), TCF7L1(2), TCF7L2(3), VANGL1(2), VANGL2(3), WIF1(2), WNT10B(1), WNT11(2), WNT16(1), WNT2(1), WNT2B(2), WNT3A(2), WNT4(1), WNT5B(2), WNT7A(5), WNT8B(1), WNT9A(1) 170102242 219 175 218 70 47 37 63 42 30 0 0.344 1.000 1.000 410 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 73 ARAF(4), BRAF(3), C7orf16(2), CACNA1A(13), CRHR1(2), GNAI1(1), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAS(5), GRIA1(8), GRIA2(3), GRIA3(10), GRID2(6), GRM1(5), GRM5(2), GUCY1A2(5), GUCY1A3(1), GUCY1B3(2), GUCY2C(6), GUCY2D(2), GUCY2F(4), IGF1(1), IGF1R(2), ITPR1(10), ITPR2(7), ITPR3(6), LYN(4), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NOS1(7), NOS3(3), NPR1(3), NPR2(2), NRAS(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PPP2CA(2), PPP2CB(3), PPP2R1A(1), PPP2R2A(1), PRKCG(2), PRKG1(3), PRKG2(6), RAF1(1), RYR1(16) 122854274 206 175 205 58 42 46 58 35 25 0 0.0299 1.000 1.000 411 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 105 ACTN1(1), ACTN2(9), ACTN3(1), ACTN4(6), ARHGAP5(3), BCAR1(2), CD99(2), CLDN11(1), CLDN14(1), CLDN15(1), CLDN16(1), CLDN17(2), CLDN19(1), CLDN22(2), CLDN6(1), CTNNA1(4), CTNNA2(8), CTNNA3(6), CTNNB1(1), CTNND1(1), CYBB(1), ESAM(2), EZR(3), F11R(2), GNAI1(1), GNAI2(2), GNAI3(1), GRLF1(7), ICAM1(1), ITGA4(2), ITGAL(1), ITGAM(3), ITGB1(3), ITGB2(4), ITK(4), JAM3(1), MAPK13(1), MAPK14(2), MLLT4(12), MMP9(1), MSN(2), MYL5(1), MYLPF(1), NCF1(3), NCF2(4), NCF4(1), NOX1(1), NOX3(1), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PLCG1(6), PLCG2(3), PRKCG(2), PTK2(5), PTK2B(3), PTPN11(1), RAPGEF3(2), RAPGEF4(3), RASSF5(2), RHOA(2), ROCK1(4), ROCK2(4), SIPA1(1), TXK(2), VAV1(4), VAV2(2), VAV3(4), VCAM1(4), VCL(4) 132798851 195 168 195 67 29 36 56 34 40 0 0.685 1.000 1.000 412 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(2), ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(7), ADCY6(1), ADCY7(7), ADCY8(7), ADK(1), ADSL(2), AK2(1), AK5(2), AMPD1(6), AMPD2(1), AMPD3(1), ATIC(3), ATP1B1(2), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(2), CANT1(1), DGUOK(2), ENPP1(5), ENPP3(2), ENTPD1(2), ENTPD2(2), FHIT(1), GART(1), GDA(1), GMPS(2), GUCY1A2(5), GUCY1A3(1), GUCY1B3(2), GUCY2C(6), GUCY2D(2), GUCY2F(4), IMPDH1(2), IMPDH2(1), NPR1(3), NPR2(2), NT5E(5), NT5M(1), NUDT2(1), PAICS(1), PAPSS1(2), PDE1A(2), PDE4A(1), PDE4B(4), PDE4C(5), PDE4D(6), PDE5A(1), PDE6B(2), PDE6C(6), PDE7B(1), PDE8A(1), PDE9A(5), PFAS(1), PKLR(3), PKM2(1), POLB(1), POLD1(1), POLD2(1), POLE(7), POLG(4), POLL(1), POLQ(8), POLR1B(2), POLR2A(5), POLR2B(7), POLR2C(1), POLR2F(2), POLR2H(1), POLR2J(2), PPAT(1), PRPS2(1), PRUNE(4), RRM1(2), RRM2(1) 141799104 205 167 201 69 37 30 71 32 35 0 0.680 1.000 1.000 413 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 73 ACTB(2), ACTG1(4), ACTN1(1), ACTN2(9), ACTN3(1), ACTN4(6), ACVR1B(6), ACVR1C(2), CREBBP(7), CSNK2A1(1), CSNK2A2(1), CTNNA1(4), CTNNA2(8), CTNNA3(6), CTNNB1(1), CTNND1(1), EGFR(5), EP300(7), FARP2(5), FER(1), IGF1R(2), INSR(4), IQGAP1(2), LMO7(2), MAP3K7(1), MAPK1(1), MAPK3(1), MET(7), MLLT4(12), NLK(2), PARD3(4), PTPRB(10), PTPRF(6), PTPRJ(3), PTPRM(3), PVRL1(2), PVRL2(3), PVRL3(4), PVRL4(2), RHOA(2), SMAD2(4), SMAD3(3), SMAD4(3), SNAI1(2), SNAI2(1), SORBS1(5), SSX2IP(1), TCF7(3), TCF7L1(2), TCF7L2(3), TGFBR1(2), TGFBR2(3), TJP1(6), VCL(4), WAS(3), WASF1(5), WASF3(1), WASL(1), YES1(2) 130711315 205 166 203 62 37 36 59 24 49 0 0.499 1.000 1.000 414 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 89 ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(7), ADCY6(1), ADCY7(7), ADCY8(7), ADCY9(9), DRD2(2), EGF(3), EGFR(5), GJA1(2), GNAI1(1), GNAI2(2), GNAI3(1), GNAQ(1), GNAS(5), GRB2(1), GRM1(5), GRM5(2), GUCY1A2(5), GUCY1A3(1), GUCY1B3(2), GUCY2C(6), GUCY2D(2), GUCY2F(4), HTR2A(3), HTR2B(1), HTR2C(2), ITPR1(10), ITPR2(7), ITPR3(6), MAP2K1(1), MAP2K2(1), MAP2K5(2), MAPK1(1), MAPK3(1), NPR1(3), NPR2(2), NRAS(1), PDGFB(2), PDGFRA(3), PDGFRB(3), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PRKACA(2), PRKACG(1), PRKCG(2), PRKG1(3), PRKG2(6), PRKX(2), RAF1(1), SOS1(4), SOS2(4), TJP1(6), TUBA1A(1), TUBA1B(2), TUBA1C(2), TUBA3C(4), TUBA3D(1), TUBA4A(1), TUBAL3(1), TUBB(1), TUBB2A(1), TUBB2B(1), TUBB2C(3), TUBB3(1), TUBB4(1), TUBB6(1) 145234258 206 166 205 70 46 34 62 38 26 0 0.473 1.000 1.000 415 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 80 ACVR1(1), ACVR1B(6), ACVRL1(1), AURKB(1), BMPR2(3), BUB1(1), CDKL1(3), CDKL2(1), CDS1(3), CDS2(2), CLK1(2), CLK4(1), COL4A3BP(1), CSNK2A1(1), CSNK2A2(1), DGKA(3), DGKB(4), DGKD(3), DGKE(2), DGKG(6), DGKH(1), DGKQ(1), IMPA1(1), INPP4A(4), INPP4B(5), INPP5A(2), INPPL1(4), ITPKA(1), ITPKB(7), MAP3K10(4), MOS(3), NEK1(1), NEK3(4), OCRL(6), PAK4(1), PIK3C2A(4), PIK3C2B(6), PIK3C2G(3), PIK3CB(6), PIK3CG(3), PIM2(2), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PLCD1(1), PLCG1(6), PLCG2(3), PLK3(1), PRKACA(2), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(6), PRKCZ(1), PRKD1(2), PRKG1(3), RAF1(1), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KA4(1), RPS6KB1(2), STK11(2), TGFBR1(2), VRK1(2) 123527377 190 164 187 56 35 26 55 36 38 0 0.320 1.000 1.000 416 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 147 ADORA1(1), ADORA2A(2), ADORA3(2), ADRA1A(2), ADRA1B(1), ADRB2(1), AVPR1B(2), AVPR2(3), BDKRB1(2), BDKRB2(1), BRS3(3), C3AR1(2), CCKAR(1), CCKBR(1), CCR1(1), CCR2(5), CCR3(1), CCR5(2), CCR7(3), CCRL1(1), CCRL2(2), CHML(4), CHRM1(2), CHRM2(4), CHRM3(1), CHRM5(2), CMKLR1(2), CNR1(2), CNR2(1), CX3CR1(3), CXCR3(5), DRD2(2), DRD3(1), DRD5(2), EDNRA(1), EDNRB(2), F2R(3), F2RL2(1), FPR1(1), FSHR(4), GALR1(2), GALR2(2), GALT(1), GHSR(1), GNB2L1(3), GPR17(2), GPR174(3), GPR3(2), GPR35(1), GPR37(2), GPR50(2), GPR6(2), GPR63(1), GPR77(1), GPR83(4), GPR85(1), GRPR(1), HCRTR1(2), HCRTR2(3), HRH1(2), HRH2(2), HRH3(2), HTR1A(4), HTR1B(1), HTR1E(3), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(2), HTR5A(5), LHCGR(5), MAS1(2), MC3R(2), MC4R(2), NMBR(2), NMUR1(1), NMUR2(2), NPY1R(4), NPY2R(1), NTSR2(1), OPRD1(2), OPRK1(2), OPRL1(2), OPRM1(5), P2RY1(3), P2RY10(2), P2RY11(1), P2RY13(3), P2RY2(1), P2RY6(1), PPYR1(1), PTGDR(1), PTGFR(1), RHO(4), SSTR2(1), SSTR3(2) 120528259 199 163 200 75 52 25 52 45 25 0 0.471 1.000 1.000 417 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 90 ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(7), ADCY6(1), ADCY7(7), ADCY8(7), ADCY9(9), ATF4(2), CACNA1C(10), CACNA1D(7), CACNA1F(11), CACNA1S(5), CAMK2A(2), CAMK2D(4), CAMK2G(1), EGFR(5), ELK1(2), GNAQ(1), GNAS(5), GNRH1(1), GRB2(1), ITPR1(10), ITPR2(7), ITPR3(6), JUN(3), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K6(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), MMP14(2), NRAS(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PLD1(5), PLD2(2), PRKACA(2), PRKACG(1), PRKCD(2), PRKX(2), PTK2B(3), RAF1(1), SOS1(4), SOS2(4) 135716809 197 162 197 78 47 31 60 37 22 0 0.826 1.000 1.000 418 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(6), ABCA10(7), ABCA12(5), ABCA13(16), ABCA2(1), ABCA3(6), ABCA4(7), ABCA5(6), ABCA6(4), ABCA7(7), ABCA8(10), ABCA9(5), ABCB1(4), ABCB10(5), ABCB11(7), ABCB4(2), ABCB5(4), ABCB6(3), ABCB7(5), ABCB8(5), ABCB9(1), ABCC1(3), ABCC10(3), ABCC11(3), ABCC12(6), ABCC2(5), ABCC3(4), ABCC4(4), ABCC5(4), ABCC6(4), ABCC8(7), ABCC9(10), ABCD1(4), ABCD2(2), ABCD3(2), ABCD4(1), ABCG1(2), ABCG2(1), ABCG4(1), ABCG5(2), CFTR(9), TAP1(2) 131376662 195 160 195 55 35 30 71 33 26 0 0.0928 1.000 1.000 419 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(10), ASH2L(3), CARM1(2), CTCFL(3), DOT1L(5), EED(3), EHMT1(6), EZH1(1), EZH2(1), FBXO11(2), HCFC1(11), JMJD6(1), KDM6A(10), MEN1(4), MLL(10), MLL2(13), MLL4(6), MLL5(7), NSD1(2), OGT(3), PAXIP1(5), PRDM2(3), PRDM6(2), PRDM7(2), PRDM9(2), PRMT1(1), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), RBBP5(2), SATB1(2), SETD1A(2), SETD1B(3), SETD2(11), SETD7(2), SETD8(1), SETDB1(9), SETDB2(1), SETMAR(1), SMYD3(3), SUV420H1(5), SUZ12(4), WHSC1(7), WHSC1L1(4) 124699313 184 158 182 32 27 26 53 30 47 1 0.0141 1.000 1.000 420 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 104 ABL1(5), ANAPC1(3), ANAPC10(1), ANAPC4(2), ANAPC5(5), ANAPC7(4), ATM(18), ATR(6), BUB1(1), CCNA1(1), CCNA2(3), CCNB1(2), CCNB3(7), CCND1(1), CCND3(2), CCNE1(1), CCNE2(1), CCNH(2), CDC14A(2), CDC14B(1), CDC20(1), CDC23(1), CDC25A(1), CDC25B(3), CDC25C(2), CDC6(3), CDC7(1), CDK2(1), CDK4(1), CDK6(1), CDK7(2), CHEK2(3), CREBBP(7), CUL1(2), E2F1(4), E2F3(1), EP300(7), ESPL1(9), HDAC1(4), HDAC2(4), MAD2L1(2), MAD2L2(1), MCM2(2), MCM3(2), MCM4(3), MCM6(2), MCM7(4), MDM2(2), ORC1L(1), ORC2L(3), ORC3L(2), PLK1(2), PRKDC(10), PTTG1(1), PTTG2(1), RBL1(3), RBL2(1), SKP2(1), SMAD2(4), SMAD3(3), SMAD4(3), SMC1A(5), SMC1B(4), TFDP1(2), TGFB1(2), TGFB3(1), WEE1(2), YWHAB(1), YWHAG(1), YWHAZ(1) 148533174 198 158 196 42 27 32 58 34 47 0 0.0429 1.000 1.000 421 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 91 ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(7), ADCY6(1), ADCY7(7), ADCY8(7), ADCY9(9), AKAP1(3), AKAP11(5), AKAP12(3), AKAP3(2), AKAP4(7), AKAP6(7), AKAP7(1), AKAP8(2), AKAP9(14), ARHGEF1(7), GNA14(1), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNB1(1), GNB2(1), GNB3(3), IL18BP(1), ITPR1(10), KCNJ3(1), NRAS(1), PALM2(3), PDE1A(2), PDE1B(2), PDE1C(2), PDE4A(1), PDE4B(4), PDE4C(5), PDE4D(6), PDE7B(1), PDE8A(1), PLCB3(3), PPP3CA(4), PRKACA(2), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(6), PRKCZ(1), PRKD1(2), PRKD3(3), RHOA(2), SLC9A1(1), USP5(4) 130470480 185 157 185 62 36 28 59 39 23 0 0.522 1.000 1.000 422 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 74 ABL1(5), ACTN1(1), AKT2(3), AKT3(4), ANGPTL2(1), ARHGEF6(4), ARHGEF7(2), BCAR1(2), BRAF(3), CAV1(2), CRK(1), CSE1L(3), EPHB2(3), GRB2(1), GRB7(5), GRLF1(7), ILK(2), ITGA1(5), ITGA10(2), ITGA11(5), ITGA2(3), ITGA3(1), ITGA4(2), ITGA5(2), ITGA6(4), ITGA7(5), ITGA8(3), ITGA9(2), ITGB3BP(2), MAP2K7(1), MAP3K11(1), MAPK1(1), MAPK10(2), MAPK8(2), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), MYLK(8), MYLK2(2), P4HB(1), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PIK3CB(6), PKLR(3), PLCG1(6), PLCG2(3), PTK2(5), RAF1(1), RHO(4), ROCK1(4), ROCK2(4), SHC1(1), SOS1(4), SOS2(4), TERF2IP(3), TLN1(12), TLN2(5), WAS(3) 130726130 188 157 188 61 37 34 47 34 36 0 0.451 1.000 1.000 423 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(4), AMY2A(1), ASCC3(4), ATP13A2(1), DDX18(2), DDX23(1), DDX4(3), DDX41(3), DDX50(3), DDX51(1), DDX54(1), DDX55(4), DDX56(2), DHX58(2), ENPP1(5), ENPP3(2), ENTPD7(4), EP400(5), ERCC2(1), ERCC3(2), G6PC(1), G6PC2(2), GAA(2), GANC(2), GBA(1), GBA3(2), GBE1(3), GCK(2), GPI(2), GUSB(3), GYS1(5), GYS2(1), HK1(1), HK2(2), HK3(2), IFIH1(3), MGAM(12), MOV10L1(4), NUDT5(1), PGM1(1), PGM3(1), PYGB(3), PYGL(2), PYGM(5), RAD54B(6), RAD54L(2), SETX(11), SI(9), SKIV2L2(2), SMARCA2(5), SMARCA5(2), TREH(1), UGDH(1), UGP2(1), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2A1(1), UGT2B10(1), UGT2B11(2), UGT2B15(3), UGT2B28(4), UGT2B4(2), UGT2B7(1), UXS1(2) 139066234 179 155 179 46 27 33 48 46 25 0 0.121 1.000 1.000 424 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 97 ADCY1(3), ADCY3(3), ADCY4(2), ADCY5(7), ADCY6(1), ADCY7(7), ADCY8(7), ADCY9(9), CAMK2A(2), CAMK2D(4), CAMK2G(1), CREB1(1), CREB3(1), CREB3L1(1), CREB3L2(2), CREB3L3(4), CREB3L4(2), CREBBP(7), CTNNB1(1), DCT(2), DVL1(2), DVL3(2), EDN1(2), EDNRB(2), EP300(7), FZD1(1), FZD2(1), FZD3(3), FZD6(3), FZD7(1), FZD8(2), FZD9(3), GNAI1(1), GNAI2(2), GNAI3(1), GNAO1(2), GNAQ(1), GNAS(5), KIT(5), KITLG(3), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PRKACA(2), PRKACG(1), PRKCG(2), PRKX(2), RAF1(1), TCF7(3), TCF7L1(2), TCF7L2(3), TYR(6), TYRP1(4), WNT10B(1), WNT11(2), WNT16(1), WNT2(1), WNT2B(2), WNT3A(2), WNT4(1), WNT5B(2), WNT7A(5), WNT8B(1), WNT9A(1) 114755322 182 154 181 61 48 35 54 28 17 0 0.344 1.000 1.000 425 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(5), BDKRB1(2), BDKRB2(1), C1QA(1), C1QB(1), C1QC(1), C1S(2), C2(1), C3(7), C3AR1(2), C4BPA(4), C4BPB(2), C5(4), C5AR1(1), C6(5), C7(6), C9(1), CD46(2), CD55(2), CFB(1), CFH(12), CPB2(1), CR1(10), CR2(4), F13A1(4), F13B(3), F2(4), F2R(3), F5(14), F7(1), F8(7), F9(1), FGA(5), FGB(1), FGG(4), KLKB1(1), KNG1(4), MASP1(3), MASP2(2), MBL2(1), PLAT(3), PLAU(2), PLAUR(1), PLG(4), PROC(1), PROS1(1), SERPINA1(5), SERPINA5(3), SERPINC1(4), SERPIND1(1), SERPINE1(3), SERPINF2(1), SERPING1(2), TFPI(2), VWF(10) 100804240 179 152 177 49 20 30 68 30 31 0 0.231 1.000 1.000 426 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 89 AKT3(4), BCAR1(2), CAPN1(4), CAPN10(1), CAPN11(1), CAPN2(3), CAPN3(2), CAPN6(2), CAPN7(1), CAV1(2), CRK(1), GRB2(1), ILK(2), ITGA10(2), ITGA11(5), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(2), ITGA5(2), ITGA6(4), ITGA7(5), ITGA8(3), ITGA9(2), ITGAD(3), ITGAE(1), ITGAL(1), ITGAM(3), ITGAV(6), ITGAX(5), ITGB1(3), ITGB2(4), ITGB3(3), ITGB4(4), ITGB5(2), ITGB6(2), ITGB8(2), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K6(1), MAPK10(2), MAPK4(6), MAPK6(3), MYLK2(2), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PTK2(5), RAPGEF1(4), RHO(4), ROCK1(4), ROCK2(4), SDCCAG8(6), SEPP1(2), SHC1(1), SHC3(1), SORBS1(5), SOS1(4), TLN1(12), TNS1(7), VAV2(2), VAV3(4), VCL(4) 149289623 190 152 188 71 35 38 45 38 34 0 0.841 1.000 1.000 427 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 66 ADCY1(3), ADCY8(7), ARAF(4), ATF4(2), BRAF(3), CACNA1C(10), CAMK2A(2), CAMK2D(4), CAMK2G(1), CAMK4(3), CREBBP(7), EP300(7), GNAQ(1), GRIA1(8), GRIA2(3), GRIN1(1), GRIN2A(12), GRIN2B(9), GRIN2C(4), GRIN2D(4), GRM1(5), GRM5(2), ITPR1(10), ITPR2(7), ITPR3(6), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), NRAS(1), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PPP1R12A(3), PPP1R1A(2), PPP3CA(4), PPP3CB(3), PPP3R1(1), PRKACA(2), PRKACG(1), PRKCG(2), PRKX(2), RAF1(1), RAPGEF3(2), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KA6(3) 112928110 182 148 181 53 40 33 53 32 24 0 0.100 1.000 1.000 428 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 88 AKT2(3), AKT3(4), BCL10(1), CARD11(4), CBL(4), CBLB(10), CBLC(2), CD28(1), CD3E(2), CD3G(2), CD4(4), CD40LG(1), CD8A(2), CDK4(1), CHUK(1), CTLA4(1), GRAP2(1), GRB2(1), ICOS(1), IFNG(2), IKBKB(4), IL2(1), ITK(4), JUN(3), LAT(1), LCK(1), LCP2(1), MALT1(1), MAP3K8(2), NCK1(1), NCK2(1), NFAT5(6), NFATC2(2), NFATC3(4), NFATC4(5), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), NRAS(1), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PDCD1(1), PDK1(1), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PLCG1(6), PPP3CA(4), PPP3CB(3), PPP3R1(1), PRKCQ(6), PTPRC(3), RHOA(2), SOS1(4), SOS2(4), TEC(2), VAV1(4), VAV2(2), VAV3(4), ZAP70(2) 104711986 169 144 169 54 23 42 51 28 24 1 0.462 1.000 1.000 429 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 78 ABL1(5), ABL2(4), AKT2(3), AKT3(4), ARAF(4), AREG(1), BRAF(3), BTC(1), CAMK2A(2), CAMK2D(4), CAMK2G(1), CBL(4), CBLB(10), CBLC(2), CRK(1), CRKL(1), EGF(3), EGFR(5), ELK1(2), ERBB3(11), ERBB4(6), GAB1(2), GRB2(1), JUN(3), MAP2K1(1), MAP2K2(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK3(1), MAPK8(2), MYC(1), NCK1(1), NCK2(1), NRAS(1), NRG1(2), NRG3(4), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PLCG1(6), PLCG2(3), PRKCG(2), PTK2(5), RAF1(1), RPS6KB1(2), RPS6KB2(4), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(4), SOS2(4), STAT5A(4), STAT5B(5), TGFA(1) 102812029 173 143 173 47 29 35 50 33 26 0 0.146 1.000 1.000 430 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 121 ARAF(4), BID(4), BRAF(3), CD244(1), FAS(1), FASLG(2), FCGR3A(1), FCGR3B(1), GRB2(1), HLA-C(2), HLA-E(1), HLA-G(2), ICAM1(1), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), IFNAR1(1), IFNAR2(1), IFNB1(1), IFNG(2), ITGAL(1), ITGB2(4), KIR2DL1(1), KIR2DL3(4), KIR2DL4(2), KIR3DL1(1), KIR3DL2(5), KLRC1(3), KLRC3(1), KLRK1(1), LAT(1), LCK(1), LCP2(1), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MICA(1), NCR1(3), NCR2(3), NFAT5(6), NFATC2(2), NFATC3(4), NFATC4(5), NRAS(1), PAK1(2), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PLCG1(6), PLCG2(3), PPP3CA(4), PPP3CB(3), PPP3R1(1), PRF1(2), PRKCG(2), PTK2B(3), PTPN11(1), RAF1(1), SHC1(1), SHC2(1), SHC3(1), SHC4(2), SOS1(4), SOS2(4), SYK(2), TNFRSF10D(1), ULBP1(1), ULBP2(1), ULBP3(2), VAV1(4), VAV2(2), VAV3(4), ZAP70(2) 117249416 173 142 173 55 23 43 54 25 28 0 0.391 1.000 1.000 431 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 105 ALG1(1), ALG10(1), ALG10B(3), ALG11(1), ALG12(3), ALG13(6), ALG14(1), ALG2(2), ALG3(1), ALG6(1), ALG8(1), ALG9(2), B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), B4GALT5(2), C1GALT1(1), C1GALT1C1(1), CHPF(1), CHST1(1), CHST11(2), CHST2(3), CHST3(1), CHSY1(1), DPAGT1(2), EXT1(5), EXT2(6), EXTL3(4), FUT11(1), GALNT10(2), GALNT11(4), GALNT13(3), GALNT2(1), GALNT3(2), GALNT4(1), GALNT5(3), GALNT7(4), GALNT8(3), GALNT9(4), GALNTL1(1), GALNTL4(1), GALNTL5(4), GANAB(3), GCNT4(2), HS2ST1(2), HS3ST2(3), HS3ST5(4), HS6ST2(5), HS6ST3(1), MAN1A1(1), MAN1A2(2), MAN1B1(6), MAN2A1(3), MGAT3(2), MGAT4A(1), MGAT4B(3), MGAT5(4), MGAT5B(5), NDST3(2), OGT(3), RPN1(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1), ST6GALNAC1(3), STT3B(2), UST(3), WBSCR17(5), XYLT1(2), XYLT2(1) 118284641 171 140 170 64 31 31 38 35 36 0 0.803 1.000 1.000 432 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 78 ABL1(5), ATM(18), BUB1(1), CCNA1(1), CCNA2(3), CCNB1(2), CCNB3(7), CCND3(2), CCNE1(1), CCNE2(1), CCNH(2), CDAN1(2), CDC14A(2), CDC14B(1), CDC20(1), CDC25A(1), CDC25B(3), CDC25C(2), CDC6(3), CDC7(1), CDK2(1), CDK4(1), CHEK2(3), DTX4(2), E2F1(4), E2F3(1), E2F5(1), EP300(7), ESPL1(9), HDAC1(4), HDAC2(4), HDAC3(1), HDAC4(2), HDAC5(3), HDAC6(6), HDAC8(4), MAD2L1(2), MAD2L2(1), MCM2(2), MCM3(2), MCM4(3), MCM6(2), MCM7(4), MDM2(2), MPEG1(2), MPL(1), ORC1L(1), ORC2L(3), ORC3L(2), PLK1(2), PRKDC(10), PTPRA(2), PTTG1(1), PTTG2(1), RBL1(3), SKP2(1), SMAD4(3), TBC1D8(4), TFDP1(2), TGFB1(2), WEE1(2) 119941501 172 139 170 41 21 31 51 27 42 0 0.0941 1.000 1.000 433 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 84 ACVR1(1), ACVR1B(6), ACVR1C(2), ACVR2A(4), ACVR2B(1), ACVRL1(1), AMHR2(3), BMP2(3), BMP4(2), BMP5(1), BMP6(2), BMP8B(1), BMPR1B(3), BMPR2(3), CHRD(3), COMP(5), CREBBP(7), CUL1(2), E2F5(1), EP300(7), FST(2), GDF6(2), ID2(1), IFNG(2), INHBA(3), INHBB(1), INHBC(1), INHBE(1), LEFTY2(1), LTBP1(5), MAPK1(1), MAPK3(1), MYC(1), NODAL(1), PITX2(3), PPP2CA(2), PPP2CB(3), PPP2R1A(1), PPP2R2A(1), RBL1(3), RBL2(1), RHOA(2), ROCK1(4), ROCK2(4), RPS6KB1(2), RPS6KB2(4), SMAD1(1), SMAD2(4), SMAD3(3), SMAD4(3), SMAD5(1), SMAD9(2), SMURF1(2), SMURF2(1), SP1(3), TFDP1(2), TGFB1(2), TGFB3(1), TGFBR1(2), TGFBR2(3), THBS1(4), THBS2(1), THBS3(3), THBS4(2), ZFYVE16(3), ZFYVE9(3) 107308695 157 136 154 41 29 25 38 31 34 0 0.168 1.000 1.000 434 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 82 ANPEP(6), CD14(2), CD19(3), CD1A(1), CD1B(4), CD1C(3), CD1D(3), CD1E(3), CD2(3), CD22(1), CD33(1), CD34(2), CD36(1), CD37(1), CD38(3), CD3E(2), CD3G(2), CD4(4), CD44(2), CD5(2), CD55(2), CD8A(2), CD9(2), CR1(10), CR2(4), CSF1(3), CSF2RA(2), CSF3R(3), DNTT(4), EPOR(4), FCGR1A(1), FLT3(3), FLT3LG(2), IL11(1), IL11RA(4), IL1A(1), IL1R1(1), IL1R2(5), IL3RA(2), IL4R(4), IL5RA(2), IL6(2), IL6R(1), IL7R(4), IL9R(2), ITGA1(5), ITGA2(3), ITGA2B(1), ITGA3(1), ITGA4(2), ITGA5(2), ITGA6(4), ITGAM(3), ITGB3(3), KIT(5), KITLG(3), MS4A1(1), TFRC(1), TPO(5) 91414405 159 131 159 41 25 31 45 32 26 0 0.0638 1.000 1.000 435 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 88 CD2BP2(1), CDC40(2), CLK3(1), CLK4(1), COL2A1(5), CPSF1(4), CPSF3(3), CPSF4(3), CSTF2(1), CSTF2T(2), CSTF3(4), DDX20(2), DHX15(2), DHX16(1), DHX38(2), DHX8(2), DHX9(2), DICER1(5), FUS(2), GIPC1(1), METTL3(2), NCBP1(1), NONO(2), NUDT21(1), NXF1(3), PABPN1(1), PAPOLA(2), POLR2A(5), PRPF3(2), PRPF4(4), PRPF4B(6), PRPF8(7), PSKH1(2), PTBP1(3), RBM17(1), RNGTT(1), SF3A1(1), SF3B2(3), SF3B4(2), SF4(6), SFRS12(1), SFRS14(2), SFRS16(4), SFRS2(1), SFRS4(2), SFRS5(1), SFRS7(1), SFRS8(1), SFRS9(1), SNRPB(1), SNRPN(2), SNURF(1), SPOP(1), SRPK1(2), SRRM1(3), SUPT5H(7), TXNL4A(1), U2AF1(1), U2AF2(1), XRN2(4) 112498802 139 122 139 27 23 34 42 23 16 1 0.0152 1.000 1.000 436 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 88 ACTB(2), CABIN1(5), CAMK4(3), CD3E(2), CD3G(2), CD69(2), CNR1(2), CREBBP(7), CSNK2A1(1), CTLA4(1), EGR2(2), EGR3(2), EP300(7), FCER1A(4), FCGR3A(1), GRLF1(7), GSK3A(3), ICOS(1), IFNA1(1), IFNB1(1), IFNG(2), IL2(1), IL6(2), ITK(4), KPNA5(2), MAP2K7(1), MAPK14(2), MAPK8(2), MEF2B(1), MEF2D(2), MYF5(1), NCK2(1), NFAT5(6), NFATC2(2), NFATC3(4), NFATC4(5), NFKB2(3), NFKBIE(1), NUP214(5), OPRD1(2), PAK1(2), PPP3CB(3), PPP3R1(1), PTPRC(3), RELA(1), RPL13A(3), SP1(3), SP3(4), TGFB1(2), TRPV6(2), VAV1(4), VAV2(2), VAV3(4), XPO5(4) 97296281 143 121 142 45 17 31 40 20 34 1 0.490 1.000 1.000 437 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 92 AKT2(3), AKT3(4), CD14(2), CD40(1), CD86(2), CHUK(1), IFNA1(1), IFNA10(1), IFNA13(1), IFNA14(2), IFNA16(1), IFNA17(1), IFNA2(3), IFNA21(1), IFNA4(1), IFNA6(2), IFNAR1(1), IFNAR2(1), IFNB1(1), IKBKB(4), IKBKE(2), IL12A(1), IL12B(1), IL6(2), IRAK1(2), IRAK4(3), IRF3(3), IRF5(1), IRF7(1), JUN(3), LBP(1), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K6(1), MAP2K7(1), MAP3K7(1), MAP3K8(2), MAPK1(1), MAPK10(2), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), NFKB1(4), NFKB2(3), NFKBIA(1), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), RELA(1), RIPK1(3), SPP1(2), STAT1(1), TBK1(1), TICAM1(5), TIRAP(1), TLR1(1), TLR2(1), TLR3(5), TLR5(2), TLR7(8), TLR8(3), TLR9(1), TRAF3(2), TRAF6(3) 87954480 135 119 132 37 16 33 31 21 32 2 0.144 1.000 1.000 438 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 79 ATF2(2), BRAF(3), CHUK(1), CREB1(1), DAXX(2), ELK1(2), GRB2(1), IKBKB(4), JUN(3), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K5(2), MAP2K6(1), MAP2K7(1), MAP3K10(4), MAP3K11(1), MAP3K12(2), MAP3K13(7), MAP3K5(2), MAP3K6(3), MAP3K7(1), MAP3K8(2), MAP3K9(4), MAP4K1(4), MAP4K3(2), MAP4K4(4), MAP4K5(1), MAPK1(1), MAPK10(2), MAPK13(1), MAPK14(2), MAPK3(1), MAPK4(6), MAPK6(3), MAPK8(2), MAPKAPK2(1), MAPKAPK3(1), MAX(3), MEF2B(1), MEF2C(3), MEF2D(2), MYC(1), NFKB1(4), NFKBIA(1), PAK1(2), PAK2(2), RAF1(1), RELA(1), RIPK1(3), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KA4(1), RPS6KA5(4), RPS6KB1(2), RPS6KB2(4), SHC1(1), SP1(3), STAT1(1), TGFB1(2), TGFB3(1), TGFBR1(2) 97646957 139 119 138 35 30 28 36 16 29 0 0.0705 1.000 1.000 439 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 FN3K(1), IMPA1(1), INPP4A(4), INPP4B(5), INPP5A(2), INPP5B(5), INPPL1(4), IPMK(1), ITGB1BP3(1), ITPK1(1), ITPKA(1), ITPKB(7), MINPP1(1), OCRL(6), PI4KA(5), PI4KB(1), PIK3C3(2), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIP4K2A(1), PIP4K2C(6), PIP5K1A(2), PIP5K1B(1), PIP5K1C(4), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), PLCD1(1), PLCD3(3), PLCD4(1), PLCE1(12), PLCG1(6), PLCG2(3), PLCZ1(8), SYNJ1(2), SYNJ2(1) 77989547 128 117 125 32 22 18 38 22 28 0 0.147 1.000 1.000 440 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 66 ACACB(9), ACSL1(1), ACSL3(1), ACSL4(2), ACSL5(2), ACSL6(2), AKT2(3), AKT3(4), CAMKK1(3), CAMKK2(2), CD36(1), CHUK(1), CPT1A(4), CPT1B(2), CPT1C(3), CPT2(5), G6PC(1), G6PC2(2), IKBKB(4), IRS1(2), IRS4(6), JAK1(4), JAK2(5), JAK3(5), LEPR(4), MAPK10(2), MAPK8(2), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), NPY(1), PCK1(2), PCK2(3), PPARA(2), PPARGC1A(5), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKAG2(1), PRKAG3(3), PRKCQ(6), PTPN11(1), RELA(1), RXRA(1), RXRG(1), SLC2A4(1), STAT3(3), STK11(2), TNFRSF1A(1), TYK2(5) 87319205 135 114 135 34 24 25 34 21 30 1 0.0894 1.000 1.000 441 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 75 AIFM1(1), AKT2(3), AKT3(4), APAF1(3), ATM(18), BAX(2), BID(4), BIRC3(1), CAPN1(4), CAPN2(3), CASP6(2), CASP7(1), CASP9(1), CHUK(1), CSF2RB(3), DFFB(2), FAS(1), FASLG(2), IKBKB(4), IL1A(1), IL1R1(1), IL1RAP(7), IL3RA(2), IRAK1(2), IRAK2(3), IRAK3(1), IRAK4(3), NFKB1(4), NFKB2(3), NFKBIA(1), NTRK1(4), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PPP3CA(4), PPP3CB(3), PPP3R1(1), PRKACA(2), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RELA(1), RIPK1(3), TNFRSF10D(1), TNFRSF1A(1) 84917738 130 112 129 28 16 32 30 21 30 1 0.0341 1.000 1.000 442 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 84 CAD(10), CANT1(1), CTPS(1), CTPS2(3), DPYS(1), ENTPD1(2), ENTPD4(3), ENTPD5(1), ENTPD6(2), NME4(1), NME6(1), NME7(4), NT5C1B(4), NT5C3(1), NT5E(5), NT5M(1), NUDT2(1), PNPT1(3), POLA1(5), POLD1(1), POLD2(1), POLD4(1), POLE(7), POLE2(1), POLE3(1), POLR1A(6), POLR1B(2), POLR1C(2), POLR1D(4), POLR2A(5), POLR2B(7), POLR2C(1), POLR2F(2), POLR2H(1), POLR2J(2), POLR3A(2), POLR3B(2), POLR3GL(3), RRM1(2), RRM2(1), TXNRD1(2), TXNRD2(1), TYMS(1), UCK1(1), UCK2(2), UMPS(3), UPB1(3), UPP1(3), UPRT(2) 90696126 122 110 119 41 20 20 35 21 26 0 0.601 1.000 1.000 443 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(1), AGPAT1(1), AGPAT2(1), AGPAT3(2), AGPAT4(2), AGPAT6(2), CDS1(3), CDS2(2), CHAT(1), CHKB(2), CHPT1(3), DGKA(3), DGKB(4), DGKD(3), DGKE(2), DGKG(6), DGKH(1), DGKI(7), DGKQ(1), ESCO1(3), ETNK1(3), ETNK2(1), GNPAT(3), GPAM(1), GPD1(2), GPD1L(1), GPD2(1), LCAT(1), MYST3(4), MYST4(9), PCYT1A(2), PCYT1B(3), PHOSPHO1(2), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLD1(5), PLD2(2), PNPLA3(2), PPAP2A(1), PPAP2C(2), PTDSS1(2), PTDSS2(2), SH3GLB1(1) 72332366 115 103 112 37 22 17 30 29 16 1 0.528 1.000 1.000 444 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 58 AKT2(3), AKT3(4), CDK2(1), CREB1(1), CREB3(1), CREB5(1), EBP(1), ERBB4(6), F2RL2(1), GAB1(2), GRB2(1), GSK3A(3), IFI27(2), IGF1(1), INPPL1(4), IRS1(2), IRS4(6), MET(7), MYC(1), NOLC1(2), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PARD3(4), PDK1(1), PIK3CD(4), PPP1R13B(3), PREX1(10), PTK2(5), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KB1(2), SHC1(1), SLC2A4(1), SOS1(4), SOS2(4), TSC1(4), TSC2(2), YWHAB(1), YWHAG(1), YWHAZ(1) 77477469 118 103 117 34 23 23 38 16 18 0 0.317 1.000 1.000 445 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 59 ATM(18), CCNA1(1), CCNB1(2), CCND1(1), CCND3(2), CCNE1(1), CCNE2(1), CCNG2(2), CCNH(2), CDC25A(1), CDK2(1), CDK4(1), CDK7(2), CREB3(1), CREB3L1(1), CREB3L3(4), CREB3L4(2), E2F1(4), E2F3(1), E2F5(1), MCM2(2), MCM3(2), MCM4(3), MCM6(2), MCM7(4), MDM2(2), MNAT1(2), MYC(1), MYT1(5), NACA(3), ORC1L(1), ORC2L(3), ORC3L(2), POLE(7), POLE2(1), RBL1(3), RPA1(1), RPA2(1), RPA3(2), TFDP1(2), TFDP2(4), TNXB(9), WEE1(2) 78190658 113 102 112 25 16 21 34 19 23 0 0.0681 1.000 1.000 446 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 69 AKT2(3), AKT3(4), BTK(4), FCER1A(4), GAB2(2), GRB2(1), INPP5D(4), LAT(1), LCP2(1), LYN(4), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K6(1), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), NRAS(1), PDK1(1), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCG1(6), PLCG2(3), PRKCD(2), PRKCE(2), RAF1(1), SOS1(4), SOS2(4), SYK(2), VAV1(4), VAV2(2), VAV3(4) 72502816 109 102 109 30 18 26 29 20 16 0 0.112 1.000 1.000 447 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 58 AKT2(3), AKT3(4), BCL10(1), BLNK(1), BTK(4), CARD11(4), CD19(3), CD22(1), CD72(1), CD79A(1), CD79B(1), CHUK(1), CR2(4), IFITM1(1), IKBKB(4), INPP5D(4), JUN(3), LYN(4), MALT1(1), NFAT5(6), NFATC2(2), NFATC3(4), NFATC4(5), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), NRAS(1), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PLCG2(3), PPP3CA(4), PPP3CB(3), PPP3R1(1), RASGRP3(1), SYK(2), VAV1(4), VAV2(2), VAV3(4) 75141392 112 98 112 37 13 27 35 16 20 1 0.572 1.000 1.000 448 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 43 AKT2(3), AKT3(4), BCR(3), BLNK(1), BTK(4), CD19(3), CD22(1), CR2(4), DAG1(1), FLOT1(1), FLOT2(2), GRB2(1), GSK3A(3), INPP5D(4), ITPR1(10), ITPR2(7), ITPR3(6), LYN(4), MAP4K1(4), MAPK1(1), MAPK3(1), NFATC2(2), NR0B2(2), PDK1(1), PIK3CD(4), PLCG2(3), PPP1R13B(3), PPP3CA(4), PPP3CB(3), PTPRC(3), RAF1(1), SHC1(1), SOS1(4), SOS2(4), SYK(2), VAV1(4) 75503807 109 98 109 32 18 25 32 21 13 0 0.188 1.000 1.000 449 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(7), B3GALT4(2), CDR1(1), DGKI(7), IL6ST(6), RPL10(2), RPL13A(3), RPL14(1), RPL17(1), RPL18(4), RPL18A(2), RPL19(1), RPL26(2), RPL29(1), RPL3(1), RPL35(2), RPL36(1), RPL3L(1), RPL4(1), RPL41(1), RPL5(3), RPL7(1), RPL8(1), RPLP0(1), RPLP2(1), RPS10(1), RPS14(1), RPS15(1), RPS16(1), RPS2(1), RPS21(1), RPS27(1), RPS4X(2), RPS5(4), RPS6(2), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KA6(3), RPS6KB1(2), RPS6KB2(4), RPSA(1), SLC36A2(2), TBC1D10C(2), UBA52(1), UBC(8) 58849603 102 95 101 23 18 14 37 17 16 0 0.265 1.000 1.000 450 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT2(3), AKT3(4), ASAH1(1), BRAF(3), DAG1(1), DRD2(2), EGFR(5), EPHB2(3), GRB2(1), ITPKA(1), ITPKB(7), ITPR1(10), ITPR2(7), ITPR3(6), KCNJ3(1), KCNJ5(1), MAPK1(1), PI3(1), PIK3CB(6), PITX2(3), PLCB1(4), PLCB2(2), PLCB3(3), PLCB4(7), RAF1(1), RGS20(2), SHC1(1), SOS1(4), SOS2(4), STAT3(3), TERF2IP(3) 64306320 101 94 101 26 16 22 25 22 16 0 0.0882 1.000 1.000 451 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 42 CREBBP(7), DLL1(2), DLL4(1), DTX1(4), DTX2(4), DTX3(1), DTX4(2), DVL1(2), DVL3(2), EP300(7), HDAC1(4), HDAC2(4), JAG1(3), MAML1(2), MAML2(4), MAML3(5), NCSTN(2), NOTCH1(5), NOTCH2(8), NOTCH3(3), NOTCH4(8), NUMB(2), NUMBL(5), PSEN1(1), PSEN2(3), PSENEN(1), PTCRA(1), RBPJL(5), RFNG(2), SNW1(2) 65438803 102 91 99 27 20 18 25 12 27 0 0.169 1.000 1.000 452 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 65 AKT2(3), AKT3(4), CASP9(1), KDR(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK13(1), MAPK14(2), MAPK3(1), MAPKAPK2(1), MAPKAPK3(1), NFAT5(6), NFATC2(2), NFATC3(4), NFATC4(5), NOS3(3), NRAS(1), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCG1(6), PLCG2(3), PPP3CA(4), PPP3CB(3), PPP3R1(1), PRKCG(2), PTGS2(2), PTK2(5), RAF1(1), SH2D2A(1), SHC2(1), SPHK2(2) 71236847 101 91 101 38 13 27 31 15 15 0 0.636 1.000 1.000 453 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM10(1), ATP6AP1(2), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), CHUK(1), EGFR(5), F11R(2), GIT1(1), IGSF5(2), IKBKB(4), JAM3(1), JUN(3), LYN(4), MAPK10(2), MAPK13(1), MAPK14(2), MAPK8(2), MET(7), NFKB1(4), NFKB2(3), NFKBIA(1), NOD1(3), PAK1(2), PLCG1(6), PLCG2(3), PTPN11(1), PTPRZ1(8), RELA(1), TCIRG1(1), TJP1(6) 78286253 98 91 98 25 14 19 32 11 21 1 0.205 1.000 1.000 454 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 40 AKT2(3), AKT3(4), ANGPTL2(1), ARHGAP4(1), ARHGEF11(3), BTK(4), GDI1(4), INPPL1(4), ITPR1(10), ITPR2(7), ITPR3(6), LIMK1(4), MYLK(8), MYLK2(2), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PDK1(1), PIK3CD(4), PIK3CG(3), PITX2(3), PPP1R13B(3), RHO(4), ROCK1(4), ROCK2(4), RPS4X(2), SAG(1), WASF1(5), WASL(1) 72185532 106 91 106 35 18 21 30 20 17 0 0.442 1.000 1.000 455 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 65 ATP8A1(2), AVPR1B(2), AVPR2(3), BDKRB1(2), BDKRB2(1), BRS3(3), C3AR1(2), CCKAR(1), CCKBR(1), CCR1(1), CCR2(5), CCR3(1), CCR5(2), CCR7(3), CX3CR1(3), CXCR3(5), EDNRA(1), EDNRB(2), FPR1(1), FSHR(4), GALR1(2), GALR2(2), GALT(1), GHSR(1), GNB2L1(3), GPR77(1), GRPR(1), LHCGR(5), MC2R(2), MC3R(2), MC4R(2), NMBR(2), NPY1R(4), NPY2R(1), NTSR2(1), OPRD1(2), OPRK1(2), OPRL1(2), OPRM1(5), PPYR1(1), SSTR2(1), SSTR3(2), TACR1(1), TACR2(2), TACR3(1), TSHR(4) 56107893 98 89 98 33 22 15 27 23 11 0 0.253 1.000 1.000 456 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 26 BRAF(3), CPEB1(4), EGFR(5), ERBB4(6), ETS1(3), ETS2(5), ETV6(2), ETV7(2), FMN2(13), GRB2(1), MAP2K1(1), MAPK1(1), MAPK3(1), NOTCH1(5), NOTCH2(8), NOTCH3(3), NOTCH4(8), PIWIL1(8), PIWIL2(4), PIWIL3(5), PIWIL4(2), RAF1(1), SOS1(4), SOS2(4), SPIRE1(1), SPIRE2(1) 50606262 101 88 99 30 13 25 26 16 21 0 0.389 1.000 1.000 457 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 65 ACOX1(2), ACOX2(1), ACOX3(2), ACSL1(1), ACSL3(1), ACSL4(2), ACSL5(2), ACSL6(2), APOA5(1), CD36(1), CPT1A(4), CPT1B(2), CPT1C(3), CPT2(5), CYP27A1(2), CYP4A11(1), CYP4A22(1), CYP7A1(1), CYP8B1(3), EHHADH(3), FABP1(1), FABP2(1), FABP4(1), FABP6(1), FADS2(4), GK(1), GK2(3), HMGCS2(1), ILK(2), LPL(1), PCK1(2), PCK2(3), PLTP(1), PPARA(2), PPARG(2), RXRA(1), RXRG(1), SCD(1), SLC27A1(1), SLC27A2(2), SLC27A4(5), SLC27A5(3), SORBS1(5), UBC(8), UCP1(1) 70854759 94 87 94 32 16 20 24 19 15 0 0.579 1.000 1.000 458 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(1), ADCY4(2), ADCY6(1), ADCY8(7), CACNA1A(13), CACNA1B(9), GNAS(5), GNAT3(1), GNB1(1), GNB3(3), GRM4(1), ITPR3(6), KCNB1(4), PDE1A(2), PLCB2(2), PRKACA(2), PRKACG(1), PRKX(2), SCNN1B(2), SCNN1G(1), TAS1R1(1), TAS1R2(1), TAS1R3(1), TAS2R1(1), TAS2R10(3), TAS2R13(2), TAS2R14(2), TAS2R16(3), TAS2R3(1), TAS2R38(1), TAS2R40(1), TAS2R42(1), TAS2R43(3), TAS2R46(1), TAS2R5(1), TAS2R8(1), TAS2R9(2), TRPM5(4) 62556795 96 87 97 32 23 17 26 18 12 0 0.239 1.000 1.000 459 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 54 ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), ALDH1A3(3), ALDH3B2(2), AOC2(1), AOC3(3), AOX1(4), CARM1(2), DBH(3), DCT(2), DDC(1), ESCO1(3), FAH(1), GSTZ1(1), HEMK1(1), HGD(1), HPD(2), LCMT1(1), LCMT2(5), MAOA(2), MAOB(1), METTL2B(2), MYST3(4), MYST4(9), PNPLA3(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), SH3GLB1(1), TAT(2), TH(1), TPO(5), TYR(6), TYRP1(4), WBSCR22(2) 64825432 97 85 97 27 18 23 29 11 15 1 0.231 1.000 1.000 460 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(4), AMY2A(1), ENPP1(5), ENPP3(2), G6PC(1), GAA(2), GANAB(3), GBA3(2), GBE1(3), GCK(2), GPI(2), GUSB(3), GYS1(5), GYS2(1), HK1(1), HK2(2), HK3(2), MGAM(12), PGM1(1), PGM3(1), PYGB(3), PYGL(2), PYGM(5), RNPC3(1), SI(9), UCHL3(1), UGDH(1), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2B15(3), UGT2B4(2), UXS1(2) 65078794 93 85 93 29 14 17 22 25 15 0 0.466 1.000 1.000 461 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 54 BMP2(3), BMP4(2), BMP5(1), BMP6(2), BMP8B(1), BTRC(2), CSNK1A1(1), CSNK1A1L(3), CSNK1E(2), CSNK1G3(2), DHH(1), GLI1(3), GLI2(5), GLI3(8), LRP2(24), PRKACA(2), PRKACG(1), PRKX(2), PTCH1(6), PTCH2(1), SMO(2), SUFU(2), WNT10B(1), WNT11(2), WNT16(1), WNT2(1), WNT2B(2), WNT3A(2), WNT4(1), WNT5B(2), WNT7A(5), WNT8B(1), WNT9A(1), ZIC2(1) 62492805 96 84 96 27 32 9 22 20 13 0 0.233 1.000 1.000 462 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3L1(1), CAD(10), CANT1(1), CTPS(1), CTPS2(3), DPYS(1), ENTPD1(2), NT5E(5), NT5M(1), NUDT2(1), POLB(1), POLD1(1), POLD2(1), POLE(7), POLG(4), POLL(1), POLQ(8), POLR1B(2), POLR2A(5), POLR2B(7), POLR2C(1), POLR2F(2), POLR2H(1), POLR2J(2), RRM1(2), RRM2(1), TXNRD1(2), TYMS(1), UCK1(1), UCK2(2), UMPS(3), UPB1(3), UPP1(3) 63346775 87 80 84 28 10 16 26 11 24 0 0.532 1.000 1.000 463 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 52 ALG2(2), BAK1(2), BAX(2), BFAR(2), BTK(4), CAD(10), CSNK1A1(1), DAXX(2), EGFR(5), EPHB2(3), IL1A(1), MAP2K7(1), MAP3K5(2), MAPK1(1), MAPK10(2), MAPK8(2), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), MET(7), NFAT5(6), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), NR0B2(2), PTPN13(5), RALBP1(1), RIPK1(3), ROCK1(4), SMPD1(1), TUFM(2) 69526682 89 80 88 21 13 22 24 11 18 1 0.119 1.000 1.000 464 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(4), CD28(1), CTLA4(1), DAG1(1), EPHB2(3), FBXW7(6), GRAP2(1), GRB2(1), ITK(4), ITPKA(1), ITPKB(7), LAT(1), LCK(1), LCP2(1), MAPK1(1), NCK1(1), NFAT5(6), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), PLCG1(6), PTPRC(3), RAF1(1), RASGRP2(2), RASGRP3(1), RASGRP4(1), SOS1(4), SOS2(4), VAV1(4), ZAP70(2) 61246445 88 80 88 29 17 20 21 17 12 1 0.531 1.000 1.000 465 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(1), AGPAT1(1), AGPAT2(1), AGPAT3(2), AGPAT4(2), AGPS(1), CDS1(3), CDS2(2), CHAT(1), CHKB(2), CLC(1), CPT1B(2), DGKA(3), DGKB(4), DGKD(3), DGKE(2), DGKG(6), DGKH(1), DGKQ(1), ETNK1(3), GNPAT(3), GPD1(2), GPD2(1), LCAT(1), LGALS13(2), PAFAH1B1(3), PCYT1A(2), PCYT1B(3), PLA2G2E(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PLCB2(2), PLCG1(6), PLCG2(3), PPAP2A(1), PPAP2C(2) 54557613 85 79 83 28 15 12 23 22 13 0 0.524 1.000 1.000 466 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ACAT1(2), AFMID(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(3), AOX1(4), ASMT(1), CARM1(2), CAT(1), CYP1A2(3), CYP1B1(1), DDC(1), EHHADH(3), GCDH(1), HAAO(1), HADH(2), HEMK1(1), HSD17B10(1), HSD17B4(6), INMT(3), KMO(1), KYNU(1), LCMT1(1), LCMT2(5), LNX1(4), MAOA(2), MAOB(1), METTL2B(2), NFX1(2), OGDH(4), OGDHL(4), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), TDO2(1), TPH2(2), WARS2(1), WBSCR22(2) 67826383 88 78 87 31 12 24 34 10 8 0 0.548 1.000 1.000 467 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 68 ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), AKR1C1(3), AKR1C2(4), AKR1C3(1), AKR1C4(2), ALDH1A3(3), ALDH3B2(2), CYP1A2(3), CYP1B1(1), CYP2B6(4), CYP2C18(2), CYP2C19(1), CYP2C8(3), CYP2C9(2), CYP2E1(1), CYP2F1(1), CYP2S1(4), CYP3A4(3), CYP3A43(1), CYP3A7(4), EPHX1(1), GSTA1(1), GSTA2(1), GSTA4(1), GSTK1(2), GSTO2(2), GSTP1(1), GSTT1(1), GSTZ1(1), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2A1(1), UGT2B10(1), UGT2B11(2), UGT2B15(3), UGT2B28(4), UGT2B4(2), UGT2B7(1) 63570817 87 77 86 29 14 19 31 13 10 0 0.489 1.000 1.000 468 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(5), AXIN1(1), CCND1(1), CCND3(2), CSNK1E(2), CTNNB1(1), DVL1(2), DVL3(2), FBXW2(2), FZD1(1), FZD2(1), FZD3(3), FZD6(3), FZD7(1), FZD8(2), FZD9(3), JUN(3), LDLR(1), MAPK10(2), MYC(1), PAFAH1B1(3), PLAU(2), PPP2R5C(1), PPP2R5E(1), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCI(1), PRKCQ(6), PRKCZ(1), PRKD1(2), RHOA(2), SFRP4(2), TCF7(3), WNT10B(1), WNT11(2), WNT16(1), WNT2(1), WNT2B(2), WNT4(1), WNT5B(2), WNT7A(5) 61995744 85 77 85 29 22 14 20 19 10 0 0.373 1.000 1.000 469 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(3), ATP4A(5), ATP4B(4), ATP5A1(1), ATP5B(1), ATP5C1(2), ATP5F1(2), ATP6AP1(2), ATP6V0A2(2), ATP6V0A4(2), ATP6V0B(1), ATP6V0D2(2), ATP6V0E1(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), COX10(3), COX15(1), COX4I2(2), COX5A(1), COX6C(1), COX7B2(1), NDUFA1(1), NDUFA10(1), NDUFA13(1), NDUFA2(1), NDUFA3(1), NDUFA4(1), NDUFA6(1), NDUFA9(2), NDUFB3(1), NDUFB4(1), NDUFB5(3), NDUFB9(2), NDUFS2(2), NDUFS3(1), NDUFS5(1), NDUFS7(1), NDUFS8(1), NDUFV1(3), NDUFV2(1), NDUFV3(1), PPA1(2), PPA2(1), SDHB(1), TCIRG1(1), UQCRC1(3), UQCRC2(1) 63095295 84 76 85 21 15 9 29 16 15 0 0.203 1.000 1.000 470 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 31 APC(5), AR(5), ASAH1(1), BRAF(3), CCL13(2), DAG1(1), EGFR(5), GNAI1(1), GNAQ(1), ITPKA(1), ITPKB(7), ITPR1(10), ITPR2(7), ITPR3(6), KCNJ3(1), KCNJ5(1), MAPK1(1), MAPK10(2), MAPK14(2), PHKA2(9), PIK3CD(4), PITX2(3), PTX3(1), RAF1(1) 54143285 80 76 80 26 9 15 21 22 13 0 0.503 1.000 1.000 471 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 44 AKT2(3), AKT3(4), BRD4(2), CAP1(2), CBL(4), F2RL2(1), FLOT1(1), FLOT2(2), GRB2(1), GSK3A(3), INPPL1(4), IRS1(2), IRS4(6), MAPK1(1), MAPK3(1), PARD3(4), PDK1(1), PIK3CD(4), PPYR1(1), RAF1(1), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KB1(2), SERPINB6(1), SHC1(1), SLC2A4(1), SORBS1(5), SOS1(4), SOS2(4), YWHAB(1), YWHAG(1), YWHAZ(1) 56512488 79 75 79 29 19 13 27 10 10 0 0.713 1.000 1.000 472 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(2), ALPL(1), ALPP(2), ALPPL2(3), ASCC3(4), ATP13A2(1), DDX18(2), DDX23(1), DDX4(3), DDX41(3), DDX50(3), DDX51(1), DDX54(1), DDX55(4), DDX56(2), DHX58(2), ENTPD7(4), EP400(5), ERCC2(1), ERCC3(2), FPGS(1), GCH1(1), IFIH1(3), MOV10L1(4), NUDT5(1), RAD54B(6), RAD54L(2), SETX(11), SKIV2L2(2), SMARCA2(5), SMARCA5(2) 69121848 85 74 84 18 15 15 27 18 10 0 0.0783 1.000 1.000 473 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 27 ACTA1(2), BDKRB2(1), CAV1(2), CHRM1(2), CHRNA1(1), FLT1(2), FLT4(1), KDR(2), NOS3(3), PDE2A(4), PDE3A(8), PDE3B(2), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PRKG1(3), PRKG2(6), RYR2(32) 44787850 78 73 78 42 10 12 32 15 9 0 0.993 1.000 1.000 474 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(1), ADH1C(1), ADH6(1), ADH7(3), ADHFE1(1), AGPAT1(1), AGPAT2(1), AGPAT3(2), AGPAT4(2), AKR1B1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CEL(2), DGAT1(1), DGKA(3), DGKB(4), DGKD(3), DGKE(2), DGKG(6), DGKH(1), DGKQ(1), GK(1), GLA(4), GLB1(2), LCT(11), LIPC(1), LIPF(2), LIPG(1), LPL(1), PNLIP(3), PNLIPRP1(3), PPAP2A(1), PPAP2C(2) 53452826 78 72 76 23 18 14 19 15 12 0 0.242 1.000 1.000 475 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 41 AKT2(3), AKT3(4), BRAF(3), EIF4B(1), FIGF(2), HIF1A(1), IGF1(1), MAPK1(1), MAPK3(1), PIK3CB(6), PIK3CD(4), PIK3CG(3), PIK3R3(2), PRKAA1(1), PRKAA2(3), RHEB(1), RICTOR(3), RPS6(2), RPS6KA1(2), RPS6KA2(4), RPS6KA3(4), RPS6KA6(3), RPS6KB1(2), RPS6KB2(4), STK11(2), TSC1(4), TSC2(2), ULK1(1), ULK2(4), ULK3(2) 51874870 76 72 76 21 12 20 18 14 12 0 0.274 1.000 1.000 476 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(2), ACTN1(1), ACTN2(9), ACTN3(1), BCAR1(2), BCR(3), CAPN1(4), CAV1(2), CRKL(1), GRB2(1), ITGA1(5), ITGB1(3), JUN(3), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(2), PPP1R12B(1), PTK2(5), RAF1(1), ROCK1(4), SHC1(1), SOS1(4), TLN1(12), VCL(4) 51971535 75 72 75 26 14 15 19 13 14 0 0.654 1.000 1.000 477 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASDHPPT(3), AASS(3), ACAT1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DLST(3), DOT1L(5), EHHADH(3), EHMT1(6), GCDH(1), HADH(2), HSD17B10(1), HSD17B4(6), NSD1(2), OGDH(4), OGDHL(4), PIPOX(1), PLOD1(2), PLOD2(2), PLOD3(3), RDH11(2), RDH12(1), RDH14(2), SETD1A(2), SETD7(2), SETDB1(9), SHMT2(1) 61870776 77 71 76 25 11 20 28 10 8 0 0.394 1.000 1.000 478 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F13B(3), F2(4), F5(14), F7(1), F8(7), F9(1), FGA(5), FGB(1), FGG(4), LPA(11), PLAT(3), PLAU(2), PLG(4), SERPINE1(3), SERPINF2(1), VWF(10) 39139070 74 70 72 22 7 9 33 13 12 0 0.453 1.000 1.000 479 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 44 ACOX1(2), CD36(1), CITED2(2), CPT1B(2), CREBBP(7), EHHADH(3), EP300(7), FABP1(1), HSD17B4(6), JUN(3), LPL(1), MAPK1(1), MAPK3(1), MRPL11(1), MYC(1), NCOA1(2), NFKBIA(1), NR0B2(2), NR2F1(1), NRIP1(3), PPARA(2), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PTGS2(2), RELA(1), RXRA(1), SP1(3), SRA1(1), STAT5A(4), STAT5B(5) 52943429 74 70 73 21 14 13 20 11 16 0 0.287 1.000 1.000 480 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 49 ACTA1(2), AGT(2), CALR(1), CAMK1(2), CAMK1G(1), CAMK4(3), CREBBP(7), CSNK1A1(1), EDN1(2), ELSPBP1(2), F2(4), HAND2(1), IGF1(1), LIF(3), MAP2K1(1), MAPK1(1), MAPK14(2), MAPK3(1), MAPK8(2), MEF2C(3), MYH2(3), NFATC2(2), NFATC3(4), NFATC4(5), NPPA(1), PPP3CA(4), PPP3CB(3), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RAF1(1), RPS6KB1(2) 50210308 74 69 74 28 6 12 30 14 12 0 0.799 1.000 1.000 481 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 38 ALK(3), AR(5), ESR1(3), ESR2(2), HNF4A(3), NR1D1(2), NR1D2(1), NR1I2(1), NR1I3(1), NR2C2(2), NR2E1(2), NR2F1(1), NR3C1(2), NR4A1(2), NR4A2(1), NR5A2(5), PGR(5), PPARA(2), PPARG(2), RARA(2), RARB(5), RARG(3), ROR1(8), RORA(1), RORC(3), RXRA(1), RXRG(1), THRA(1), THRB(1) 43183934 71 69 71 27 13 16 16 10 16 0 0.653 1.000 1.000 482 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 33 ACTG1(4), ACTG2(2), ANGPTL2(1), FLNA(5), FLNC(10), FSCN3(1), GDI1(4), LIMK1(4), MYH2(3), MYLK(8), MYLK2(2), PAK1(2), PAK2(2), PAK3(2), PAK4(1), PAK6(1), PAK7(2), RHO(4), ROCK1(4), ROCK2(4), RPS4X(2), WASF1(5), WASL(1) 49831078 74 68 74 29 14 16 24 8 12 0 0.792 1.000 1.000 483 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 48 ABL1(5), ACTB(2), ACTG1(4), ARHGEF2(3), CD14(2), CTNNB1(1), CTTN(1), EZR(3), HCLS1(1), ITGB1(3), KRT18(1), NCK1(1), NCK2(1), NCL(3), RHOA(2), ROCK1(4), ROCK2(4), TLR5(2), TUBA1A(1), TUBA1B(2), TUBA1C(2), TUBA3C(4), TUBA3D(1), TUBA4A(1), TUBAL3(1), TUBB(1), TUBB2A(1), TUBB2B(1), TUBB2C(3), TUBB3(1), TUBB4(1), TUBB6(1), WAS(3), WASL(1), YWHAZ(1) 53297145 69 66 69 26 10 11 24 10 14 0 0.744 1.000 1.000 484 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 48 ABL1(5), ACTB(2), ACTG1(4), ARHGEF2(3), CD14(2), CTNNB1(1), CTTN(1), EZR(3), HCLS1(1), ITGB1(3), KRT18(1), NCK1(1), NCK2(1), NCL(3), RHOA(2), ROCK1(4), ROCK2(4), TLR5(2), TUBA1A(1), TUBA1B(2), TUBA1C(2), TUBA3C(4), TUBA3D(1), TUBA4A(1), TUBAL3(1), TUBB(1), TUBB2A(1), TUBB2B(1), TUBB2C(3), TUBB3(1), TUBB4(1), TUBB6(1), WAS(3), WASL(1), YWHAZ(1) 53297145 69 66 69 26 10 11 24 10 14 0 0.744 1.000 1.000 485 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 38 ASAH1(1), ATF1(2), BRAF(3), CREB1(1), CREB3(1), CREB5(1), CREBBP(7), CRKL(1), DAG1(1), EGR1(1), EGR2(2), EGR3(2), ELK1(2), GNAQ(1), JUN(3), MAP1B(3), MAP2K7(1), MAPK1(1), MAPK10(2), MAPK3(1), MAPK8(2), MAPK8IP1(2), MAPK8IP2(2), MAPK8IP3(3), NTRK1(4), OPN1LW(1), PIK3C2G(3), PIK3CD(4), PTPN11(1), RPS6KA3(4), SHC1(1), TERF2IP(3), TH(1) 49471476 68 65 68 18 16 6 19 12 15 0 0.308 1.000 1.000 486 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 63 ACYP1(1), ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), ALDH1A3(3), ALDH1B1(1), ALDH3B2(2), ALDH9A1(1), ALDOA(4), ALDOB(2), ALDOC(1), DLD(1), ENO1(1), ENO3(2), G6PC(1), G6PC2(2), GAPDH(1), GCK(2), GPI(2), HK1(1), HK2(2), HK3(2), LDHC(2), PDHA1(2), PDHA2(2), PDHB(1), PFKL(1), PFKM(4), PFKP(2), PGAM2(1), PGAM4(1), PGK1(3), PGM1(1), PGM3(1), PKLR(3), PKM2(1), TPI1(2) 64247562 67 64 67 15 12 20 17 12 6 0 0.0184 1.000 1.000 487 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 29 ANGPTL2(1), DAG1(1), DGKA(3), ITGA9(2), ITPKA(1), ITPKB(7), ITPR1(10), ITPR2(7), ITPR3(6), MAP2K1(1), MAPK1(1), MAPK3(1), NR1I3(1), PAK1(2), PDE3A(8), PDE3B(2), PI3(1), PIK3C2G(3), PIK3CD(4), PLDN(1), RIPK3(2), RPS4X(2), SGCB(1) 49658724 68 64 68 24 8 16 18 17 9 0 0.597 1.000 1.000 488 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(2), ACADSB(2), ACADVL(3), ACAT1(2), ACOX1(2), ACOX3(2), ACSL1(1), ACSL3(1), ACSL4(2), ACSL5(2), ACSL6(2), ADH1A(1), ADH1C(1), ADH5(1), ADH6(1), ADH7(3), ADHFE1(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CPT1A(4), CPT1B(2), CPT1C(3), CPT2(5), CYP4A11(1), CYP4A22(1), EHHADH(3), GCDH(1), HADH(2), HADHB(2), HSD17B10(1), HSD17B4(6), PECI(1) 55157495 66 63 66 18 10 18 21 11 6 0 0.211 1.000 1.000 489 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 52 AKR1C4(2), AKR1D1(1), ARSE(2), CARM1(2), CYP11B1(2), CYP11B2(5), HEMK1(1), HSD11B1(2), HSD17B2(1), HSD3B1(1), HSD3B2(3), LCMT1(1), LCMT2(5), METTL2B(2), PRMT2(1), PRMT3(2), PRMT5(3), PRMT6(2), PRMT7(3), PRMT8(1), SRD5A1(1), SULT1E1(2), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2A1(1), UGT2B10(1), UGT2B11(2), UGT2B15(3), UGT2B28(4), UGT2B4(2), UGT2B7(1), WBSCR22(2) 54068528 70 63 70 27 14 15 26 9 6 0 0.702 1.000 1.000 490 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(3), CDC7(1), CDK2(1), DIAPH2(4), MCM10(3), MCM2(2), MCM3(2), MCM4(3), MCM6(2), MCM7(4), NACA(3), ORC1L(1), ORC2L(3), ORC3L(2), POLD1(1), POLD2(1), POLD4(1), POLE(7), POLE2(1), RFC1(4), RFC2(1), RFC4(3), RPA1(1), RPA2(1), RPA3(2), UBA52(1), UBC(8) 56595423 66 62 66 18 9 11 21 14 11 0 0.428 1.000 1.000 491 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(2), CAMK2A(2), CAMK2D(4), CAMK2G(1), CDK5(1), F2(4), GNAI1(1), GNB1(1), GRB2(1), JAK2(5), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK14(2), MAPK3(1), MAPK8(2), MAPT(3), MYLK(8), PLCG1(6), PTK2B(3), RAF1(1), SHC1(1), SOS1(4), STAT1(1), STAT3(3), STAT5A(4) 46881867 64 61 64 23 10 12 18 11 13 0 0.644 1.000 1.000 492 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(1), AGXT2(1), ALAS2(4), AMT(2), AOC2(1), AOC3(3), BHMT(1), CBS(2), CHKB(2), CTH(3), DAO(1), DLD(1), DMGDH(6), GAMT(1), GARS(1), GATM(4), GCAT(2), GLDC(3), MAOA(2), MAOB(1), PIPOX(1), RDH11(2), RDH12(1), RDH14(2), SARDH(2), SARS(3), SARS2(2), SHMT2(1), TARS(5), TARS2(6) 47666235 67 61 67 20 7 15 16 16 13 0 0.332 1.000 1.000 493 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10(1), ALG10B(3), ALG11(1), ALG12(3), ALG13(6), ALG14(1), ALG2(2), ALG3(1), ALG5(1), ALG6(1), ALG8(1), ALG9(2), B4GALT1(2), B4GALT3(1), DHDDS(1), DOLPP1(1), DPAGT1(2), DPM1(2), GANAB(3), MAN1A1(1), MAN1A2(2), MAN1B1(6), MAN2A1(3), MGAT3(2), MGAT4A(1), MGAT4B(3), MGAT5(4), MGAT5B(5), RPN1(2), STT3B(2) 46412345 67 61 66 16 7 16 17 11 16 0 0.191 1.000 1.000 494 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 40 CHUK(1), DAXX(2), EGF(3), EGFR(5), ETS1(3), ETS2(5), IKBKB(4), JUN(3), MAP2K1(1), MAP2K3(2), MAP2K6(1), MAP2K7(1), MAP3K5(2), MAPK1(1), MAPK13(1), MAPK14(2), MAPK3(1), MAPK8(2), NFKB1(4), NFKBIA(1), PPP2CA(2), PRKCD(2), PRKCE(2), PRKCG(2), PRKCH(1), PRKCQ(6), RAF1(1), RELA(1), RIPK1(3), SP1(3), TNFRSF1A(1) 49944281 69 61 69 24 10 19 12 15 13 0 0.444 1.000 1.000 495 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(2), CAPN1(4), CAPN2(3), CXCR3(5), EGF(3), EGFR(5), ITGA1(5), ITGB1(3), MAPK1(1), MAPK3(1), MYLK(8), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PTK2(5), TLN1(12) 37365417 64 61 64 24 11 14 20 12 7 0 0.710 1.000 1.000 496 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(1), AGXT2(1), ALAS2(4), AMT(2), AOC2(1), AOC3(3), BHMT(1), CBS(2), CHKB(2), CPT1B(2), CTH(3), DAO(1), DLD(1), DMGDH(6), GAMT(1), GARS(1), GATM(4), GCAT(2), GLDC(3), MAOA(2), MAOB(1), PLCB2(2), PLCG1(6), PLCG2(3), SARDH(2), SARS(3), SHMT2(1), TARS(5) 46734941 66 60 66 22 8 12 16 16 14 0 0.559 1.000 1.000 497 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP4(1), ARHGAP5(3), ARHGAP6(2), ARHGEF1(7), ARHGEF11(3), ARHGEF5(2), ARPC1A(1), ARPC1B(2), ARPC2(2), DIAPH1(4), GSN(1), LIMK1(4), MYLK(8), OPHN1(4), PIP5K1A(2), PIP5K1B(1), PPP1R12B(1), ROCK1(4), TLN1(12), VCL(4) 51386817 68 60 67 29 10 14 17 11 16 0 0.908 1.000 1.000 498 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 21 APC(5), ASAH1(1), DAG1(1), DLG4(1), EPHB2(3), GNAI1(1), GNAQ(1), ITPR1(10), ITPR2(7), ITPR3(6), KCNJ3(1), KCNJ5(1), MAPK1(1), PITX2(3), PTX3(1), RHO(4), RYR1(16) 50022809 63 60 63 25 11 17 12 15 8 0 0.588 1.000 1.000 499 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ACAT1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(3), AOX1(4), ASMT(1), CAT(1), CYP1A2(3), CYP2A13(4), CYP2A6(1), CYP2A7(1), CYP2B6(4), CYP2C18(2), CYP2C19(1), CYP2C8(3), CYP2C9(2), CYP2D6(1), CYP2E1(1), CYP2F1(1), CYP3A4(3), CYP3A7(4), CYP4B1(3), CYP4F8(4), DDC(1), EHHADH(3), GCDH(1), HAAO(1), KMO(1), KYNU(1), MAOA(2), MAOB(1), TDO2(1), WARS2(1) 62063169 71 60 70 33 7 15 26 14 9 0 0.941 1.000 1.000 500 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 50 AKR1C3(1), ALOX12(2), ALOX12B(1), ALOX15(2), ALOX15B(2), ALOX5(1), CBR1(1), CYP2B6(4), CYP2C18(2), CYP2C19(1), CYP2C8(3), CYP2C9(2), CYP2E1(1), CYP4A11(1), CYP4A22(1), CYP4F2(2), DHRS4(1), GGT1(4), GPX2(1), GPX4(1), GPX5(2), GPX7(1), PLA2G12A(1), PLA2G2D(1), PLA2G2E(1), PLA2G2F(1), PLA2G3(2), PLA2G4A(7), PLA2G6(2), PTGIS(3), PTGS1(2), PTGS2(2), TBXAS1(1) 43269832 60 58 59 19 11 9 23 8 9 0 0.367 1.000 1.000 501 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(3), ACAA2(2), ACAT1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOX1(4), AUH(1), BCAT1(4), BCAT2(3), BCKDHA(1), DLD(1), EHHADH(3), HADH(2), HADHB(2), HIBADH(1), HIBCH(2), HMGCS1(3), HMGCS2(1), HSD17B10(1), HSD17B4(6), IVD(1), MCCC1(4), MUT(3), OXCT1(1), OXCT2(1), PCCA(1), PCCB(2) 48932258 60 57 60 16 5 17 17 14 7 0 0.294 1.000 1.000 502 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 38 CD3E(2), CD3G(2), ELK1(2), GRB2(1), JUN(3), LAT(1), LCK(1), MAP2K1(1), MAPK3(1), MAPK8(2), NFATC2(2), NFATC3(4), NFATC4(5), NFKB1(4), NFKBIA(1), PLCG1(6), PPP3CA(4), PPP3CB(3), PTPN7(2), RAF1(1), RASA1(2), RELA(1), SHC1(1), SOS1(4), VAV1(4), ZAP70(2) 44100541 62 57 62 21 12 16 16 8 10 0 0.458 1.000 1.000 503 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 33 BLNK(1), BTK(4), CD79A(1), CD79B(1), ELK1(2), GRB2(1), JUN(3), LYN(4), MAP2K1(1), MAPK14(2), MAPK3(1), MAPK8(2), NFATC2(2), NFATC3(4), NFATC4(5), PLCG1(6), PPP3CA(4), PPP3CB(3), RAF1(1), SHC1(1), SOS1(4), SYK(2), VAV1(4) 38504266 59 56 59 19 9 15 16 10 9 0 0.414 1.000 1.000 504 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AMD1(1), AOC2(1), AOC3(3), ARG1(2), ARG2(1), ASL(4), CKB(1), CKMT1B(1), CKMT2(3), CPS1(7), DAO(1), GAMT(1), GATM(4), MAOA(2), MAOB(1), NOS1(7), NOS3(3), OTC(1), P4HA1(1), P4HA2(1), P4HA3(2), P4HB(1), RARS(3) 48523766 62 55 62 19 10 14 26 8 4 0 0.313 1.000 1.000 505 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CAMK1(2), CAMK1G(1), ELK1(2), FPR1(1), GNB1(1), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAP2K6(1), MAPK1(1), MAPK14(2), MAPK3(1), NCF1(3), NCF2(4), NFATC2(2), NFATC3(4), NFATC4(5), NFKB1(4), NFKBIA(1), PAK1(2), PIK3C2G(3), PLCB1(4), PPP3CA(4), PPP3CB(3), RAF1(1), RELA(1) 39346057 57 55 57 20 10 15 17 9 6 0 0.587 1.000 1.000 506 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(2), AADAC(3), ABAT(3), ACAT1(2), ACSM1(1), ALDH1A3(3), ALDH1B1(1), ALDH5A1(1), ALDH9A1(1), BDH1(1), DDHD1(2), EHHADH(3), GAD1(2), GAD2(3), HADH(2), HMGCS1(3), HMGCS2(1), HSD17B10(1), HSD17B4(6), ILVBL(1), OXCT1(1), OXCT2(1), PDHA1(2), PDHA2(2), PDHB(1), PLA1A(2), PPME1(1), RDH11(2), RDH12(1), RDH14(2) 45639536 57 55 56 19 2 17 17 14 7 0 0.587 1.000 1.000 507 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 58 A4GALT(1), B3GALNT1(1), B3GALT1(1), B3GALT2(1), B3GALT4(2), B3GALT5(2), B3GNT1(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALNT1(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), B4GALT6(1), FUT2(2), FUT3(3), FUT5(2), FUT6(2), GBGT1(1), GCNT2(1), PIGA(2), PIGB(1), PIGG(2), PIGM(1), PIGN(1), PIGO(1), PIGQ(3), PIGS(2), PIGT(1), PIGV(1), PIGZ(2), ST3GAL1(2), ST3GAL2(1), ST3GAL3(3), ST3GAL4(1), ST3GAL5(2), ST6GALNAC3(1), ST6GALNAC4(1), ST6GALNAC5(1), ST6GALNAC6(1), ST8SIA1(1) 52110992 60 55 59 23 12 14 17 6 11 0 0.621 1.000 1.000 508 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 32 ACTA1(2), CRK(1), CRKL(1), ELK1(2), GAB1(2), GRB2(1), HGF(4), ITGA1(5), ITGB1(3), JUN(3), MAP2K1(1), MAP2K2(1), MAP4K1(4), MAPK1(1), MAPK3(1), MAPK8(2), MET(7), PAK1(2), PTK2(5), PTK2B(3), PTPN11(1), RAF1(1), RASA1(2), SOS1(4), STAT3(3) 45928836 62 55 62 19 13 17 15 8 9 0 0.338 1.000 1.000 509 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(2), G6PC(1), GAA(2), GALK2(1), GALT(1), GANAB(3), GCK(2), GLA(4), GLB1(2), HK1(1), HK2(2), HK3(2), LCT(11), MGAM(12), PFKM(4), PFKP(2), PGM1(1), PGM3(1) 35865078 56 53 56 17 11 10 11 16 8 0 0.269 1.000 1.000 510 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(3), CREB1(1), ELK1(2), GNAI1(1), GNAQ(1), GNAS(5), GNB1(1), JUN(3), MAP2K1(1), MAPK3(1), NFATC2(2), NFATC3(4), NFATC4(5), PLCG1(6), PPP3CA(4), PPP3CB(3), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RAF1(1), RPS6KA3(4) 36969691 55 53 55 20 9 10 14 10 12 0 0.716 1.000 1.000 511 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(3), ATP4B(4), ATP6AP1(2), ATP6V0A4(2), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1B2(1), ATP6V1C1(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(1), ATP7A(7), ATP7B(2), COX10(3), COX5A(1), COX6C(1), NDUFA1(1), NDUFA10(1), NDUFA4(1), NDUFB4(1), NDUFB5(3), NDUFS2(2), NDUFV1(3), NDUFV2(1), PPA2(1), SDHB(1), UQCRC1(3) 43706867 55 50 55 19 13 6 16 10 10 0 0.684 1.000 1.000 512 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 29 AKT2(3), AKT3(4), ANKRD6(4), APC(5), AXIN1(1), AXIN2(1), CER1(1), CSNK1A1(1), CTNNB1(1), DACT1(2), DKK2(1), DKK3(2), DKK4(1), DVL1(2), GSK3A(3), LRP1(11), MVP(1), NKD1(1), NKD2(1), PSEN1(1), PTPRA(2), SFRP1(2), WIF1(2) 43287565 53 50 53 20 11 14 13 7 8 0 0.588 1.000 1.000 513 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(2), ACTN1(1), ACTN2(9), ACTN3(1), CAPN1(4), ITGA1(5), ITGB1(3), ITGB3(3), PTK2(5), SPTAN1(4), TLN1(12) 32339637 49 49 49 15 11 9 13 11 5 0 0.507 1.000 1.000 514 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(5), ELK1(2), GNAS(5), GNB1(1), GRB2(1), IGF1R(2), ITGB1(3), KLK2(2), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MYC(1), NGFR(1), PDGFRA(3), PPP2CA(2), PTPRR(2), RAF1(1), RPS6KA1(2), RPS6KA5(4), SHC1(1), SOS1(4), STAT3(3) 36412137 49 48 49 17 11 14 10 9 5 0 0.504 1.000 1.000 515 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 22 AKT2(3), AKT3(4), GRB2(1), GSK3A(3), IL4R(4), IRS1(2), JAK1(4), JAK3(5), MAP4K1(4), MAPK1(1), MAPK3(1), PDK1(1), PIK3CD(4), PPP1R13B(3), RAF1(1), SHC1(1), SOS1(4), SOS2(4), STAT6(2) 32888932 52 48 52 14 10 9 14 9 10 0 0.282 1.000 1.000 516 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 20 ARHGAP5(3), DIAPH1(4), GSN(1), ITGA1(5), ITGB1(3), MAP2K1(1), MAPK1(1), MAPK3(1), MYLK(8), PTK2(5), RAF1(1), ROCK1(4), SHC1(1), TLN1(12) 38436182 50 47 49 17 6 12 15 9 8 0 0.668 1.000 1.000 517 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 25 ALDH1A3(3), ALDH3B2(2), AOC2(1), AOC3(3), DDC(1), EPX(4), ESCO1(3), HPD(2), LPO(5), MAOA(2), MAOB(1), MPO(3), MYST3(4), MYST4(9), PNPLA3(2), SH3GLB1(1), TAT(2), TPO(5) 37191744 53 47 53 16 13 7 13 10 9 1 0.411 1.000 1.000 518 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS2(4), BLVRB(1), COX10(3), COX15(1), CP(3), EARS2(3), EPRS(4), GUSB(3), HMBS(1), HMOX2(1), PPOX(2), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2A1(1), UGT2B10(1), UGT2B11(2), UGT2B15(3), UGT2B28(4), UGT2B4(2), UGT2B7(1) 46673959 49 47 49 24 7 10 16 10 6 0 0.967 1.000 1.000 519 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 34 ATF2(2), CREB1(1), DAXX(2), ELK1(2), GRB2(1), MAP2K6(1), MAP3K5(2), MAP3K7(1), MAP3K9(4), MAPK14(2), MAPKAPK2(1), MAX(3), MEF2B(1), MEF2C(3), MEF2D(2), MYC(1), PLA2G4A(7), RIPK1(3), RPS6KA5(4), SHC1(1), STAT1(1), TGFB1(2), TGFB3(1), TGFBR1(2) 35927996 50 47 50 17 6 11 19 6 8 0 0.651 1.000 1.000 520 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), CDK7(2), ERCC3(2), GTF2E2(1), GTF2H1(1), ILK(2), MNAT1(2), POLR1A(6), POLR1B(2), POLR2A(5), POLR2B(7), POLR2C(1), POLR2F(2), POLR2H(1), POLR2J(2), POLR3B(2), POLR3D(1), POLR3E(2), TAF13(1), TAF5(1), TAF6(1), TAF7(1), TAF9(1), TBP(1) 38821072 49 47 46 22 7 8 13 6 15 0 0.891 1.000 1.000 521 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 35 EEF1B2(1), EEF1D(1), EEF2(4), EEF2K(4), EIF1AX(2), EIF2AK1(1), EIF2AK3(1), EIF2B1(2), EIF2B2(2), EIF2B3(1), EIF2B5(1), EIF2S1(1), EIF2S2(2), EIF2S3(2), EIF4A2(6), EIF4G1(2), EIF4G3(4), EIF5(2), EIF5B(3), ETF1(2), GSPT2(2), KIAA0664(2), PABPC1(3), SLC35A4(1) 47766171 52 47 52 18 9 12 15 6 10 0 0.654 1.000 1.000 522 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 29 B4GALT5(2), C1GALT1(1), C1GALT1C1(1), GALNT10(2), GALNT11(4), GALNT13(3), GALNT2(1), GALNT3(2), GALNT4(1), GALNT5(3), GALNT7(4), GALNT8(3), GALNT9(4), GALNTL1(1), GALNTL4(1), GALNTL5(4), GCNT4(2), OGT(3), ST3GAL1(2), ST3GAL2(1), ST6GALNAC1(3), WBSCR17(5) 36533178 53 46 53 25 9 7 14 11 12 0 0.946 1.000 1.000 523 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(3), ADRBK2(1), ARRB2(1), CAMK2A(2), CAMK2D(4), CAMK2G(1), CLCA1(2), CLCA2(1), CLCA4(2), CNGA3(5), CNGA4(2), CNGB1(2), GUCA1A(2), GUCA1C(1), PDC(1), PDE1C(2), PRKACA(2), PRKACG(1), PRKG1(3), PRKG2(6), PRKX(2) 34582616 46 45 46 22 6 9 13 14 4 0 0.930 1.000 1.000 524 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 31 ADH1A(1), ADH1C(1), ADH6(1), ADH7(3), ADHFE1(1), ALDH1A3(3), ALDH3B2(2), AOC2(1), AOC3(3), AOX1(4), DBH(3), DCT(2), DDC(1), FAH(1), GSTZ1(1), HGD(1), HPD(2), MAOA(2), MAOB(1), TAT(2), TH(1), TPO(5), TYR(6) 34172816 48 45 48 15 11 9 15 5 8 0 0.463 1.000 1.000 525 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 23 POLA1(5), POLB(1), POLD1(1), POLD2(1), POLD4(1), POLE(7), POLE2(1), POLE3(1), POLG(4), POLH(2), POLI(3), POLL(1), POLM(1), POLQ(8), REV1(2), REV3L(8) 45787032 47 44 47 12 3 9 15 9 11 0 0.458 1.000 1.000 526 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(1), APC(5), ATF2(2), AXIN1(1), BMP10(1), BMP2(3), BMP4(2), BMP5(1), BMPR2(3), CHRD(3), CTNNB1(1), DVL1(2), FZD1(1), MAP3K7(1), MEF2C(3), NPPA(1), RFC1(4), TGFB1(2), TGFB3(1), TGFBR1(2), TGFBR2(3), TGFBR3(2) 39579606 45 43 44 21 7 10 10 12 6 0 0.894 1.000 1.000 527 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), ALDOA(4), ALDOB(2), ALDOC(1), FUK(2), GMDS(2), HK1(1), HK2(2), HK3(2), KHK(1), MPI(2), MTMR1(1), MTMR2(1), MTMR6(2), PFKFB1(1), PFKFB3(1), PFKL(1), PFKM(4), PFKP(2), PGM2(1), RDH11(2), RDH12(1), RDH14(2), SORD(2), TPI1(2), TSTA3(1) 41210738 45 43 45 13 8 11 9 9 8 0 0.143 1.000 1.000 528 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 22 CSNK2A1(1), EGF(3), EGFR(5), ELK1(2), GRB2(1), JAK1(4), JUN(3), MAP2K1(1), MAPK3(1), MAPK8(2), PLCG1(6), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SRF(1), STAT1(1), STAT3(3), STAT5A(4) 33911573 46 41 46 16 10 7 10 8 11 0 0.621 1.000 1.000 529 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 30 CBL(4), CRKL(1), E2F1(4), GRB2(1), IL2RB(1), IL2RG(1), IRS1(2), JAK1(4), JAK3(5), MAPK1(1), MAPK3(1), MYC(1), RAF1(1), RPS6KB1(2), SHC1(1), SOS1(4), STAT5A(4), STAT5B(5), SYK(2) 33462839 45 41 45 19 8 8 12 8 9 0 0.814 1.000 1.000 530 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 30 ADRA1A(2), ADRA1B(1), ADRB2(1), CHRM1(2), CHRM2(4), CHRM3(1), CHRM5(2), DRD2(2), DRD3(1), DRD5(2), HRH1(2), HRH2(2), HTR1A(4), HTR1B(1), HTR1E(3), HTR1F(2), HTR2A(3), HTR2B(1), HTR2C(2), HTR5A(5) 27141231 43 41 43 19 16 3 11 6 7 0 0.766 1.000 1.000 531 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 19 CDK5(1), CHN1(3), LIMK1(4), MYLK(8), NCF2(4), PAK1(2), PDGFRA(3), PLD1(5), PPP1R12B(1), RALBP1(1), RPS6KB1(2), TRIO(5), VAV1(4), WASF1(5) 32404598 48 41 48 19 5 14 16 9 4 0 0.745 1.000 1.000 532 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 22 GH1(1), GHR(2), GRB2(1), INSR(4), IRS1(2), JAK2(5), MAP2K1(1), MAPK1(1), MAPK3(1), PLCG1(6), RAF1(1), RPS6KA1(2), SHC1(1), SLC2A4(1), SOS1(4), SRF(1), STAT5A(4), STAT5B(5) 31946996 43 40 43 15 10 8 10 5 10 0 0.474 1.000 1.000 533 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(1), AASDHPPT(3), AASS(3), ACAT1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), DLST(3), DOT1L(5), EHHADH(3), EHMT1(6), GCDH(1), PLOD1(2), PLOD2(2), PLOD3(3), SHMT2(1) 38376925 43 40 43 18 7 11 16 5 4 0 0.753 1.000 1.000 534 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(5), AXIN1(1), CREBBP(7), CTNNB1(1), DVL1(2), EP300(7), FZD1(1), HDAC1(4), LDB1(1), PITX2(3), TRRAP(9) 36445341 41 40 40 13 7 6 7 11 10 0 0.550 1.000 1.000 535 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 30 AGT(2), ATF2(2), EGFR(5), ELK1(2), GNAQ(1), GRB2(1), JUN(3), MAP2K1(1), MAP2K2(1), MAPK1(1), MAPK3(1), MAPK8(2), MEF2B(1), MEF2C(3), MEF2D(2), PAK1(2), PTK2(5), PTK2B(3), RAF1(1), SHC1(1), SOS1(4) 33194831 44 39 44 18 9 8 15 6 6 0 0.713 1.000 1.000 536 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 23 ARHGDIB(1), CASP6(2), CASP7(1), DAXX(2), DFFB(2), JUN(3), LMNA(1), LMNB1(1), MAP3K7(1), MAPK8(2), PAK1(2), PAK2(2), PRKDC(10), PTPN13(5), SPTAN1(4) 41051955 39 39 39 10 6 9 10 5 9 0 0.374 1.000 1.000 537 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 31 ATF1(2), CREB1(1), CREB3(1), CREB5(1), DUSP10(2), EEF2K(4), ELK1(2), IL1R1(1), MAP2K3(2), MAP2K6(1), MAP3K10(4), MAP3K5(2), MAP3K7(1), MAPK1(1), MAPK13(1), MAPK14(2), MAPKAPK2(1), MYEF2(3), NFKB1(4), NR2C2(2), SRF(1), TRAF6(3) 31327599 42 39 42 18 7 11 13 6 5 0 0.818 1.000 1.000 538 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(2), ACADSB(2), ACAT1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOX1(4), BCAT1(4), BCKDHA(1), EHHADH(3), HADHB(2), HIBADH(1), IVD(1), MCCC1(4), MUT(3), OXCT1(1), PCCA(1), PCCB(2) 40777570 41 39 41 14 3 11 13 10 4 0 0.649 1.000 1.000 539 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 23 ADCY1(3), CAMK2A(2), CAMK2D(4), CAMK2G(1), CREB1(1), GNAS(5), GRB2(1), MAPK1(1), MAPK14(2), MAPK3(1), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RPS6KA1(2), RPS6KA5(4), SOS1(4) 26584030 38 38 38 13 8 9 7 7 7 0 0.608 1.000 1.000 540 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(3), CD3E(2), CD3G(2), CD4(4), CREBBP(7), GNAS(5), GNB1(1), LCK(1), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PTPRC(3), ZAP70(2) 23886453 37 37 37 14 6 8 9 6 8 0 0.737 1.000 1.000 541 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 20 ADCY1(3), CD3E(2), CD3G(2), CD4(4), CREBBP(7), GNAS(5), GNB1(1), LCK(1), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), PTPRC(3), ZAP70(2) 23886453 37 37 37 14 6 8 9 6 8 0 0.737 1.000 1.000 542 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 22 POLR1A(6), POLR1B(2), POLR1C(2), POLR1D(4), POLR2A(5), POLR2B(7), POLR2C(1), POLR2F(2), POLR2H(1), POLR2J(2), POLR3A(2), POLR3B(2), POLR3GL(3) 26200314 39 37 36 17 6 4 9 7 13 0 0.902 1.000 1.000 543 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(1), GTF2E2(1), GTF2H1(1), GTF2H3(1), GTF2I(1), TAF1(10), TAF13(1), TAF1L(9), TAF4(2), TAF4B(2), TAF5(1), TAF5L(2), TAF6(1), TAF7(1), TAF7L(2), TAF9(1) 40044984 37 37 37 12 6 9 10 7 5 0 0.611 1.000 1.000 544 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 22 CSNK2A1(1), ELK1(2), GRB2(1), JAK1(4), JUN(3), MAP2K1(1), MAPK3(1), MAPK8(2), PDGFRA(3), PLCG1(6), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SRF(1), STAT1(1), STAT3(3), STAT5A(4) 30972874 41 37 41 12 9 7 9 5 11 0 0.375 1.000 1.000 545 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(4), EGF(3), EGFR(5), GRB2(1), MAP2K1(1), MAPK1(1), MAPK3(1), PTPRB(10), RAF1(1), RASA1(2), SHC1(1), SOS1(4), SPRY1(1), SPRY2(1), SPRY3(3) 28381502 39 37 39 21 8 7 10 8 6 0 0.986 1.000 1.000 546 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 26 CHUK(1), EGR2(2), EGR3(2), GNAQ(1), MYC(1), NFATC2(2), NFKB1(4), NFKBIA(1), PLCG1(6), PPP3CA(4), PPP3CB(3), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RELA(1), VIP(1), VIPR2(1) 26842830 37 37 37 14 4 8 9 7 9 0 0.721 1.000 1.000 547 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 28 AKR1C4(2), AKR1D1(1), ARSB(4), ARSE(2), CYP11B1(2), CYP11B2(5), HSD11B1(2), HSD17B2(1), HSD3B1(1), HSD3B2(3), SRD5A1(1), SULT1E1(2), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2B15(3), UGT2B4(2) 29995524 40 36 40 15 9 6 15 8 2 0 0.612 1.000 1.000 548 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(3), ACACA(4), ACACB(9), ACAT1(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), EHHADH(3), HIBCH(2), LDHC(2), MLYCD(2), MUT(3), PCCA(1), PCCB(2), SUCLA2(1) 44929187 39 36 39 15 2 10 14 10 3 0 0.748 1.000 1.000 549 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(2), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), CYP2C19(1), CYP2C9(2), DHRS2(4), DHRS7(1), EHHADH(3), ESCO1(3), MYST3(4), MYST4(9), PNPLA3(2), SH3GLB1(1) 34582262 37 35 37 15 3 8 12 10 3 1 0.830 1.000 1.000 550 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(3), AOC2(1), AOC3(3), CES1(2), CES7(2), DDHD1(2), ESCO1(3), LIPA(1), MYST3(4), MYST4(9), PLA1A(2), PNPLA3(2), PPME1(1), SH3GLB1(1) 28264013 36 35 35 14 4 9 8 7 7 1 0.827 1.000 1.000 551 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 23 ARNT(3), EIF2B1(2), EIF2B2(2), EIF2B3(1), EIF2B5(1), EIF2S1(1), EIF2S2(2), EIF2S3(2), ELAVL1(2), FLT1(2), FLT4(1), HIF1A(1), KDR(2), NOS3(3), PLCG1(6), PTK2(5), SHC1(1) 33287136 37 35 37 16 6 9 13 5 4 0 0.786 1.000 1.000 552 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(5), AXIN1(1), BTRC(2), CCND1(1), CREBBP(7), CSNK1A1(1), CSNK2A1(1), CTNNB1(1), DVL1(2), FZD1(1), HDAC1(4), MAP3K7(1), MYC(1), NLK(2), PPP2CA(2), TLE1(2), WIF1(2) 32297770 36 35 36 16 4 9 9 7 7 0 0.913 1.000 1.000 553 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(4), AGT(2), EDN1(2), EDNRA(1), EDNRB(2), EGF(3), EGFR(5), JUN(3), MYC(1), NFKB1(4), PLCG1(6), RELA(1) 22935997 34 34 34 14 6 8 7 8 5 0 0.728 1.000 1.000 554 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(2), ADCY1(3), CAP1(2), CCNB1(2), CDC25C(2), GNAI1(1), GNAS(5), GNB1(1), MAPK1(1), MAPK3(1), MYT1(5), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), RPS6KA1(2) 22005132 34 34 34 11 6 6 10 5 7 0 0.598 1.000 1.000 555 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 15 ABCB1(4), ATM(18), BAX(2), CPB2(1), CSNK1A1(1), FHL2(2), HIF1A(1), IGFBP3(1), MAPK8(2), MDM2(2), NQO1(1) 20443333 35 34 34 11 4 7 9 5 10 0 0.759 1.000 1.000 556 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 26 BCAR1(2), CRKL(1), GNAQ(1), GRB2(1), JUN(3), MAP2K1(1), MAP2K2(1), MAP2K3(2), MAPK1(1), MAPK14(2), MAPK3(1), MAPK8(2), PAK1(2), PLCG1(6), PTK2B(3), RAF1(1), SHC1(1), SOS1(4) 27421105 35 34 35 12 6 9 8 5 7 0 0.468 1.000 1.000 557 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(2), EPHA4(2), EPHB1(5), ITGA1(5), ITGB1(3), L1CAM(4), LYN(4), SELP(8) 17950964 33 33 33 14 10 8 10 5 0 0 0.750 1.000 1.000 558 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 24 CABIN1(5), CAMK1(2), CAMK1G(1), HDAC5(3), IGF1(1), IGF1R(2), INSR(4), MAP2K6(1), MAPK14(2), MEF2B(1), MEF2C(3), MEF2D(2), NFATC2(2), PPP3CA(4), PPP3CB(3) 30704127 36 33 36 19 3 11 11 7 4 0 0.867 1.000 1.000 559 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(4), COL4A2(5), COL4A3(2), COL4A4(5), COL4A5(6), COL4A6(7), P4HB(1), SLC23A1(2), SLC2A3(3) 29109121 35 33 35 14 7 7 11 6 4 0 0.700 1.000 1.000 560 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(1), AGT(2), COL4A1(4), COL4A2(5), COL4A3(2), COL4A4(5), COL4A5(6), COL4A6(7), REN(1) 29250009 33 32 33 14 7 6 10 5 5 0 0.801 1.000 1.000 561 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(3), ACADSB(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(3), CNDP1(3), DPYS(1), EHHADH(3), GAD1(2), GAD2(3), MLYCD(2), UPB1(3) 32216855 34 32 34 18 4 10 10 6 4 0 0.914 1.000 1.000 562 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 12 ACTN1(1), ACTN2(9), ACTN3(1), BCAR1(2), CTNNA1(4), CTNNA2(8), CTNNB1(1), PTK2(5), VCL(4) 21003993 35 32 35 14 8 6 9 5 7 0 0.750 1.000 1.000 563 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(2), ACOT11(2), ACYP1(1), DHRS2(4), DHRS7(1), EHHADH(3), ESCO1(3), FN3K(1), GCDH(1), ITGB1BP3(1), MYST3(4), MYST4(9), PNPLA3(2), SH3GLB1(1) 28973800 35 32 35 15 6 6 8 11 3 1 0.849 1.000 1.000 564 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(14), MAP2(10), PPP2CA(2), PRKACG(1), PRKAR2A(1), PRKAR2B(1), PRKCE(2) 20565300 31 31 31 11 2 5 12 6 6 0 0.902 1.000 1.000 565 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 34 BET1L(1), GOSR1(1), SNAP23(2), SNAP25(2), STX10(1), STX11(1), STX12(1), STX16(1), STX17(1), STX19(2), STX2(1), STX3(2), STX4(1), STX6(2), STX7(1), STX8(1), TSNARE1(4), USE1(2), VAMP1(1), VAMP3(1), VAMP7(1), VTI1B(1) 18337277 31 31 31 11 7 4 10 2 8 0 0.651 1.000 1.000 566 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(5), CAPN2(3), EP300(7), HDAC1(4), HDAC2(4), MEF2D(2), NFATC2(2), PPP3CA(4), PPP3CB(3) 26213419 34 31 33 14 2 9 6 6 11 0 0.813 1.000 1.000 567 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(3), ACACA(4), ACADSB(2), ACAT1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), EHHADH(3), LDHC(2), MLYCD(2), MUT(3), PCCA(1), PCCB(2), SUCLA2(1) 37548898 33 31 33 17 1 12 10 8 2 0 0.934 1.000 1.000 568 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(1), ANXA3(1), ANXA4(1), ANXA6(4), CYP11A1(1), EDN1(2), EDNRA(1), EDNRB(2), HSD11B1(2), PLA2G4A(7), PTGDR(1), PTGFR(1), PTGIS(3), PTGS1(2), PTGS2(2), S100A6(1), TBXAS1(1) 22803981 33 31 33 13 6 5 12 8 2 0 0.790 1.000 1.000 569 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 12 APC(5), CREBBP(7), EP300(7), MAP2K1(1), MAP3K7(1), MAPK3(1), SKIL(3), TGFB1(2), TGFB3(1), TGFBR1(2), TGFBR2(3) 27231683 33 31 32 10 5 9 7 7 5 0 0.546 1.000 1.000 570 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(2), ABAT(3), ACAT1(2), ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH5A1(1), ALDH9A1(1), EHHADH(3), GAD1(2), GAD2(3), OXCT1(1), PDHA1(2), PDHA2(2), PDHB(1), SDHB(1) 28804758 31 30 31 15 2 10 11 8 0 0 0.860 1.000 1.000 571 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1QB(1), C1S(2), C2(1), C3(7), C5(4), C6(5), C7(6), C9(1), MASP1(3) 23274390 31 30 31 10 5 7 10 3 6 0 0.450 1.000 1.000 572 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(3), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), AOC2(1), AOC3(3), CNDP1(3), DPYS(1), EHHADH(3), GAD1(2), GAD2(3), HIBCH(2), MLYCD(2), SRM(1), UPB1(3) 29707214 32 30 32 14 4 8 10 6 4 0 0.774 1.000 1.000 573 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 GNAQ(1), NFATC2(2), NFATC3(4), NFATC4(5), PLCG1(6), PPP3CA(4), PPP3CB(3), SP1(3), SP3(4) 21968397 32 29 32 11 1 6 10 9 6 0 0.743 1.000 1.000 574 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), GUSB(3), UGDH(1), UGP2(1), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2A1(1), UGT2B10(1), UGT2B11(2), UGT2B15(3), UGT2B28(4), UGT2B4(2), UGT2B7(1) 29774155 30 29 30 14 4 5 9 8 4 0 0.911 1.000 1.000 575 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(7), ACE2(1), AGT(2), ANPEP(6), CTSA(4), CTSG(1), ENPEP(3), MAS1(2), NLN(1), REN(1), THOP1(1) 23547354 29 29 27 13 5 5 7 4 8 0 0.916 1.000 1.000 576 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 22 CAMK1(2), CAMK1G(1), CAMK2A(2), CAMK2D(4), CAMK2G(1), CAMK4(3), HDAC5(3), MEF2B(1), MEF2C(3), MEF2D(2), PPARA(2), PPP3CA(4), PPP3CB(3), SLC2A4(1) 21981286 32 29 32 12 3 7 7 10 5 0 0.632 1.000 1.000 577 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(7), DYRK1B(1), GLI2(5), GLI3(8), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1), SMO(2), SUFU(2) 16926113 32 29 32 12 6 4 11 4 7 0 0.723 1.000 1.000 578 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRB(1), CP(3), EPRS(4), GUSB(3), HMBS(1), HMOX2(1), PPOX(2), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1), UGT2B15(3), UGT2B4(2) 31009951 29 28 29 15 3 7 8 8 3 0 0.928 1.000 1.000 579 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(6), CETP(1), CYP7A1(1), DGAT1(1), HMGCR(1), LCAT(1), LDLR(1), LIPC(1), LPL(1), LRP1(11), SCARB1(2), SOAT1(1) 29769822 28 28 28 14 5 8 9 2 4 0 0.870 1.000 1.000 580 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(3), AMT(2), ATIC(3), FTCD(1), GART(1), MTHFD1(5), MTHFD1L(4), MTHFS(2), MTR(5), SHMT2(1), TYMS(1) 21416257 28 27 28 11 1 7 11 4 5 0 0.802 1.000 1.000 581 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(3), ABCC2(5), ABCG2(1), BCHE(3), CES1(2), CES2(1), CYP3A4(3), UGT1A10(2), UGT1A3(1), UGT1A4(3), UGT1A6(2), UGT1A8(1) 26198984 27 27 27 13 6 3 7 8 3 0 0.900 1.000 1.000 582 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 22 APC(5), AXIN1(1), CCND1(1), CD14(2), CTNNB1(1), DVL1(2), FZD1(1), GJA1(2), GNAI1(1), IRAK1(2), LBP(1), NFKB1(4), PPP2CA(2), RELA(1), TIRAP(1) 25385935 27 26 27 13 4 7 3 10 3 0 0.878 1.000 1.000 583 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 19 CSNK2A1(1), ELK1(2), GRB2(1), INSR(4), IRS1(2), JUN(3), MAP2K1(1), MAPK3(1), MAPK8(2), PTPN11(1), RAF1(1), RASA1(2), SHC1(1), SLC2A4(1), SOS1(4), SRF(1) 23391080 28 26 28 11 6 6 7 3 6 0 0.684 1.000 1.000 584 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(3), AMT(2), ATIC(3), GART(1), MTHFD1(5), MTHFD1L(4), MTHFS(2), MTR(5), SHMT2(1), TYMS(1) 20408586 27 26 27 11 1 7 11 3 5 0 0.821 1.000 1.000 585 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 12 EGFR(5), IGF1R(2), MYC(1), POLR2A(5), PPP2CA(2), TEP1(11) 27377274 26 26 26 10 5 5 7 6 3 0 0.729 1.000 1.000 586 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 23 ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH3B2(2), ALDH9A1(1), AOC2(1), AOC3(3), ASPA(2), CNDP1(3), DDC(1), HAL(2), HARS(1), MAOA(2), MAOB(1), PRPS2(1) 26568635 27 24 27 11 4 6 11 2 4 0 0.690 1.000 1.000 587 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT10(2), GALNT2(1), GALNT3(2), GALNT4(1), GALNT7(4), GALNT8(3), GALNT9(4), ST3GAL1(2), ST3GAL2(1), ST3GAL4(1), WBSCR17(5) 16610733 26 24 26 15 3 4 4 8 7 0 0.965 1.000 1.000 588 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 9 CR1(10), CR2(4), ICAM1(1), ITGAL(1), ITGB2(4), PTPRC(3) 16214824 23 23 23 11 0 7 9 4 3 0 0.891 1.000 1.000 589 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(4), EGF(3), EGFR(5), GRB2(1), MET(7), PDGFRA(3), SH3GLB1(1), SH3KBP1(3) 22173244 27 23 27 14 6 5 6 7 3 0 0.950 1.000 1.000 590 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(3), GNAS(5), GNB1(1), PPP2CA(2), PRKAA1(1), PRKAA2(3), PRKAB1(1), PRKACG(1), PRKAG2(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1) 16560908 24 23 24 11 5 3 4 5 7 0 0.958 1.000 1.000 591 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 24 BAG4(1), BIRC3(1), JUN(3), MAP3K7(1), NFKB1(4), NFKB2(3), NFKBIA(1), NFKBIE(1), NR2C2(2), RALBP1(1), RIPK1(3), TNFAIP3(2), TNFRSF1A(1) 26134515 24 23 24 13 3 6 7 1 6 1 0.956 1.000 1.000 592 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(6), GABARAP(1), GABRA1(1), GABRA2(1), GABRA3(3), GABRA4(1), GABRA5(2), GABRA6(3), GPHN(2), NSF(1), UBQLN1(1) 13596683 22 21 22 11 3 3 9 6 1 0 0.902 1.000 1.000 593 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(4), ABCB11(7), ABCB4(2), ABCC1(3), ABCC3(4), GSTP1(1) 16816867 21 21 21 15 2 4 9 3 3 0 0.981 1.000 1.000 594 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 19 B3GNT1(1), B3GNT2(1), B3GNT3(1), B3GNT4(1), B4GALT1(2), B4GALT3(1), B4GALT4(1), FUT2(2), FUT3(3), FUT5(2), FUT6(2), GCNT2(1), ST8SIA1(1) 15615127 19 19 18 10 3 3 5 3 5 0 0.874 1.000 1.000 595 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(5), AXIN1(1), BTRC(2), CTNNB1(1), DLL1(2), DVL1(2), FZD1(1), NOTCH1(5), PSEN1(1) 21202287 20 19 20 10 2 7 2 6 3 0 0.902 1.000 1.000 596 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), DHCR24(3), EBP(1), FDFT1(1), FDPS(1), HMGCR(1), IDI1(2), NQO1(1), NSDHL(1), PMVK(1), SC4MOL(1), SQLE(1), VKORC1(1) 21414468 16 16 16 13 5 2 6 1 2 0 0.996 1.000 1.000 597 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 10 CHRNG(2), MUSK(3), PTK2(5), PTK2B(3) 12836876 13 13 13 6 3 4 6 0 0 0 0.728 1.000 1.000 598 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 MAP2K3(2), MAPK14(2), NFATC2(2), PRKACG(1), PRKAR1A(4), PRKAR2A(1), PRKAR2B(1) 10636826 13 13 13 10 0 2 7 1 3 0 0.984 1.000 1.000 599 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(3), CYP2A13(4), CYP2A6(1), CYP2A7(1), XDH(4) 9184339 13 13 12 6 4 2 4 3 0 0 0.672 1.000 1.000 600 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), CYSLTR2(2), GPR109B(2), GPR161(2), GPR34(1), GPR45(1), GPR75(2) 11219658 12 12 12 10 2 1 3 5 1 0 0.981 1.000 1.000 601 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ADAM10(1), ATF3(1), CYR61(1), IFNG(2), IFRD1(1), IL18(1), IL1A(1), IL1R1(1), NR4A3(2), WDR1(1) 12077855 12 12 12 5 3 1 5 3 0 0 0.749 1.000 1.000 602 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1), EHHADH(3) 13556469 11 11 11 9 0 4 6 1 0 0 0.975 1.000 1.000 603 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(2), ACAT1(2), EHHADH(3), HADHB(2) 9550156 9 9 9 6 0 3 3 3 0 0 0.929 1.000 1.000 604 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 12 CNR1(2), CNR2(1), DNMT1(4), PTGDR(1), PTGFR(1) 11136424 9 9 9 11 3 0 2 3 1 0 0.999 1.000 1.000 605 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1) 8825917 8 8 8 5 0 3 5 0 0 0 0.889 1.000 1.000 606 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1A2(1), ALDH1A3(3), ALDH1B1(1), ALDH9A1(1) 8825917 8 8 8 5 0 3 5 0 0 0 0.889 1.000 1.000 607 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), ACYP1(1), EHHADH(3), GCDH(1), SDHB(1) 8825949 8 8 8 6 1 2 2 3 0 0 0.941 1.000 1.000 608 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS2(4), GATA1(1), HBB(1), HMBS(1) 9293125 7 7 7 4 3 1 3 0 0 0 0.906 1.000 1.000 609 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), LDLR(1), NR0B2(2), NR1H4(1), RXRA(1) 5641024 6 6 6 4 2 0 3 1 0 0 0.893 1.000 1.000 610 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(2), CHRNA1(1), SNAP25(2) 3602521 5 5 5 4 1 0 4 0 0 0 0.931 1.000 1.000 611 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 BGN(1), KERA(1), LUM(2) 4134244 4 4 4 3 2 0 1 1 0 0 0.863 1.000 1.000 612 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 EHHADH(3) 5507205 3 3 3 4 0 1 1 1 0 0 0.978 1.000 1.000 613 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1), CYP2C9(2) 2325939 3 3 3 2 0 1 2 0 0 0 0.927 1.000 1.000 614 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACAT1(2) 5960466 2 2 2 3 0 1 0 1 0 0 0.976 1.000 1.000 615 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 584187 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 616 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 5 2957134 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000