Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.057 0.303 -9999.0 0.0 -0.816 122.0 122.0 IHH -0.013 0.078 -9999.0 0.0 -0.349 8.0 8.0 SHH Np/Cholesterol/GAS1 -0.03 0.116 -9999.0 0.0 -0.504 55.0 55.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.03 0.115 0.5 55.0 -9999.0 0.0 55.0 SMO/beta Arrestin2 -0.077 0.234 -9999.0 0.0 -0.853 74.0 74.0 SMO -0.045 0.265 -9999.0 0.0 -0.859 83.0 83.0 AKT1 0.002 0.109 -9999.0 0.0 -0.391 23.0 23.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.06 0.211 -9999.0 0.0 -0.807 73.0 73.0 ADRBK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.037 0.259 -9999.0 0.0 -0.835 83.0 83.0 STIL -0.04 0.212 -9999.0 0.0 -0.715 76.0 76.0 DHH N/PTCH2 -0.067 0.2 -9999.0 0.0 -0.648 101.0 101.0 DHH N/PTCH1 -0.091 0.245 -9999.0 0.0 -0.755 104.0 104.0 PIK3CA -0.0 0.009 -9999.0 0.0 -0.279 1.0 1.0 DHH -0.023 0.132 -9999.0 0.0 -0.771 29.0 29.0 PTHLH -0.087 0.39 -9999.0 0.0 -1.078 122.0 122.0 determination of left/right symmetry -0.037 0.259 -9999.0 0.0 -0.835 83.0 83.0 PIK3R1 -0.006 0.068 -9999.0 0.0 -0.807 7.0 7.0 skeletal system development -0.085 0.38 -9999.0 0.0 -1.054 122.0 122.0 IHH N/Hhip -0.01 0.05 -9999.0 0.0 -0.436 5.0 5.0 DHH N/Hhip -0.02 0.107 -9999.0 0.0 -0.629 29.0 29.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.037 0.259 -9999.0 0.0 -0.835 83.0 83.0 pancreas development -0.004 0.045 -9999.0 0.0 -0.374 11.0 11.0 HHAT -0.001 0.026 -9999.0 0.0 -0.807 1.0 1.0 PI3K -0.005 0.052 -9999.0 0.0 -0.617 7.0 7.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.044 0.183 -9999.0 0.0 -0.807 54.0 54.0 somite specification -0.037 0.259 -9999.0 0.0 -0.835 83.0 83.0 SHH Np/Cholesterol/PTCH1 -0.072 0.208 -9999.0 0.0 -0.749 77.0 77.0 SHH Np/Cholesterol/PTCH2 -0.043 0.138 -9999.0 0.0 -0.5 81.0 81.0 SHH Np/Cholesterol/Megalin -0.136 0.218 -9999.0 0.0 -0.5 258.0 258.0 SHH 0.01 0.035 -9999.0 0.0 -0.626 1.0 1.0 catabolic process -0.049 0.261 -9999.0 0.0 -0.839 86.0 86.0 SMO/Vitamin D3 -0.076 0.228 -9999.0 0.0 -0.824 75.0 75.0 SHH Np/Cholesterol/Hhip -0.005 0.037 -9999.0 0.0 -0.502 3.0 3.0 LRP2 -0.217 0.352 -9999.0 0.0 -0.807 257.0 257.0 receptor-mediated endocytosis -0.151 0.258 -9999.0 0.0 -0.82 95.0 95.0 SHH Np/Cholesterol/BOC -0.04 0.133 -9999.0 0.0 -0.503 74.0 74.0 SHH Np/Cholesterol/CDO -0.01 0.061 -9999.0 0.0 -0.496 14.0 14.0 mesenchymal cell differentiation 0.005 0.037 0.498 3.0 -9999.0 0.0 3.0 mol:Vitamin D3 -0.032 0.224 -9999.0 0.0 -0.729 82.0 82.0 IHH N/PTCH2 -0.062 0.189 -9999.0 0.0 -0.675 83.0 83.0 CDON -0.011 0.092 -9999.0 0.0 -0.807 13.0 13.0 IHH N/PTCH1 -0.047 0.265 -9999.0 0.0 -0.846 86.0 86.0 Megalin/LRPAP1 -0.165 0.27 -9999.0 0.0 -0.617 257.0 257.0 PTCH2 -0.065 0.22 -9999.0 0.0 -0.807 80.0 80.0 SHH Np/Cholesterol -0.003 0.025 -9999.0 0.0 -0.508 1.0 1.0 PTCH1 -0.05 0.263 -9999.0 0.0 -0.844 86.0 86.0 HHIP -0.004 0.045 -9999.0 0.0 -0.375 11.0 11.0