Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.01 0.058 -9999.0 0.0 -0.33 31.0 31.0 epithelial cell differentiation -0.013 0.077 -9999.0 0.0 -0.454 29.0 29.0 CYFIP2 -0.01 0.063 -9999.0 0.0 -0.334 29.0 29.0 ENAH 0.056 0.062 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.299 0.389 -9999.0 0.0 -0.8 369.0 369.0 EPHA2 -0.005 0.063 -9999.0 0.0 -0.807 6.0 6.0 MYO6 -0.013 0.074 -9999.0 0.0 -0.43 30.0 30.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.005 0.036 -9999.0 0.0 -0.533 3.0 3.0 AQP5 -0.241 0.298 -9999.0 0.0 -0.598 395.0 395.0 CTNND1 -0.0 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.012 0.071 -9999.0 0.0 -0.423 29.0 29.0 regulation of calcium-dependent cell-cell adhesion -0.035 0.118 -9999.0 0.0 -0.434 78.0 78.0 EGF -0.167 0.327 -9999.0 0.0 -0.802 206.0 206.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.038 0.141 -9999.0 0.0 -0.588 49.0 49.0 cortical microtubule organization -0.013 0.077 -9999.0 0.0 -0.454 29.0 29.0 GO:0000145 0.024 0.074 -9999.0 0.0 -0.403 29.0 29.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.014 0.078 -9999.0 0.0 -0.459 29.0 29.0 MLLT4 -0.005 0.063 -9999.0 0.0 -0.731 7.0 7.0 ARF6/GDP -0.013 0.065 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.004 0.038 -9999.0 0.0 -0.484 6.0 6.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.035 0.078 -9999.0 0.0 -0.395 29.0 29.0 PVRL2 -0.001 0.013 -9999.0 0.0 -0.279 2.0 2.0 ZYX -0.013 0.073 -9999.0 0.0 -0.43 29.0 29.0 ARF6/GTP -0.003 0.035 -9999.0 0.0 -0.444 6.0 6.0 CDH1 -0.024 0.136 -9999.0 0.0 -0.807 29.0 29.0 EGFR/EGFR/EGF/EGF -0.253 0.267 -9999.0 0.0 -0.481 518.0 518.0 RhoA/GDP -0.013 0.072 -9999.0 0.0 -0.425 29.0 29.0 actin cytoskeleton organization 0.031 0.077 -9999.0 0.0 -0.404 30.0 30.0 IGF-1R heterotetramer -0.022 0.125 -9999.0 0.0 -0.615 36.0 36.0 GIT1 -0.001 0.02 -9999.0 0.0 -0.279 5.0 5.0 IGF1R -0.022 0.125 -9999.0 0.0 -0.616 36.0 36.0 IGF1 -0.176 0.333 -9999.0 0.0 -0.807 215.0 215.0 DIAPH1 -0.001 0.038 -9999.0 0.0 -0.668 3.0 3.0 Wnt receptor signaling pathway 0.013 0.077 0.454 29.0 -9999.0 0.0 29.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.013 0.066 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.031 0.079 -9999.0 0.0 -0.415 30.0 30.0 EFNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.029 0.083 -9999.0 0.0 -0.405 35.0 35.0 Ephrin A1/EPHA2 -0.015 0.076 -9999.0 0.0 -0.411 35.0 35.0 SEC6/SEC8 -0.014 0.072 -9999.0 0.0 -0.767 1.0 1.0 MGAT3 -0.035 0.12 -9999.0 0.0 -0.441 78.0 78.0 HGF/MET -0.11 0.21 -9999.0 0.0 -0.469 232.0 232.0 HGF -0.055 0.203 -9999.0 0.0 -0.807 67.0 67.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.01 0.058 -9999.0 0.0 -0.332 31.0 31.0 actin cable formation 0.07 0.059 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.031 0.087 -9999.0 0.0 -0.445 29.0 29.0 KIFC3 -0.014 0.075 -9999.0 0.0 -0.43 31.0 31.0 NCK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.013 0.074 -9999.0 0.0 -0.43 30.0 30.0 NCK1/GIT1 -0.001 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.013 0.077 -9999.0 0.0 -0.454 29.0 29.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.013 0.073 -9999.0 0.0 -0.43 29.0 29.0 PIP5K1C -0.013 0.073 -9999.0 0.0 -0.43 29.0 29.0 LIMA1 -0.002 0.036 -9999.0 0.0 -0.807 2.0 2.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.012 0.058 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.046 0.084 -9999.0 0.0 -0.647 4.0 4.0 IGF-1R heterotetramer/IGF1 -0.114 0.201 -9999.0 0.0 -0.445 250.0 250.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.004 0.049 -9999.0 0.0 -0.617 6.0 6.0 MET -0.135 0.301 -9999.0 0.0 -0.807 165.0 165.0 PLEKHA7 -0.014 0.08 -9999.0 0.0 -0.461 29.0 29.0 mol:GTP -0.003 0.038 -9999.0 0.0 -0.48 6.0 6.0 establishment of epithelial cell apical/basal polarity -0.013 0.068 -9999.0 0.0 -0.721 1.0 1.0 cortical actin cytoskeleton stabilization -0.01 0.058 -9999.0 0.0 -0.33 31.0 31.0 regulation of cell-cell adhesion 0.031 0.077 -9999.0 0.0 -0.404 30.0 30.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.01 0.058 -9999.0 0.0 -0.332 31.0 31.0