E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.02 0.113 -9999.0 0.0 -0.415 42.0 42.0 KLHL20 0.015 0.066 0.235 9.0 -0.222 14.0 23.0 CYFIP2 0.029 0.047 0.263 25.0 -0.577 2.0 27.0 Rac1/GDP 0.0 0.086 0.261 9.0 -0.312 19.0 28.0 ENAH -0.017 0.107 -9999.0 0.0 -0.453 26.0 26.0 AP1M1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.008 0.049 -9999.0 0.0 -0.33 2.0 2.0 ABI1/Sra1/Nap1 -0.012 0.032 -9999.0 0.0 -0.153 13.0 13.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.045 0.069 -9999.0 0.0 -0.339 21.0 21.0 RAPGEF1 -0.02 0.108 -9999.0 0.0 -0.406 29.0 29.0 CTNND1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.125 -9999.0 0.0 -0.417 50.0 50.0 CRK -0.017 0.104 -9999.0 0.0 -0.425 33.0 33.0 E-cadherin/gamma catenin/alpha catenin 0.031 0.063 -9999.0 0.0 -0.369 19.0 19.0 alphaE/beta7 Integrin 0.036 0.035 -9999.0 0.0 -0.428 2.0 2.0 IQGAP1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.04 0.028 -9999.0 0.0 -0.337 3.0 3.0 DLG1 -0.024 0.119 -9999.0 0.0 -0.446 34.0 34.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.017 0.031 -9999.0 0.0 -0.243 2.0 2.0 MLLT4 0.021 0.035 0.263 1.0 -0.577 3.0 4.0 ARF6/GTP/NME1/Tiam1 0.044 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.003 0.046 -9999.0 0.0 -0.321 2.0 2.0 ARF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.019 0.068 -9999.0 0.0 -0.342 29.0 29.0 TIAM1 0.025 0.016 0.263 4.0 -9999.0 0.0 4.0 E-cadherin(dimer)/Ca2+ 0.04 0.058 -9999.0 0.0 -0.32 19.0 19.0 AKT1 -0.007 0.035 -9999.0 0.0 -0.212 1.0 1.0 PIK3R1 0.02 0.047 -9999.0 0.0 -0.577 6.0 6.0 CDH1 0.01 0.083 -9999.0 0.0 -0.577 19.0 19.0 RhoA/GDP 0.0 0.086 0.263 6.0 -0.313 19.0 25.0 actin cytoskeleton organization 0.014 0.053 0.184 16.0 -0.164 12.0 28.0 CDC42/GDP 0.001 0.085 0.262 7.0 -0.313 19.0 26.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.007 0.045 -9999.0 0.0 -0.268 20.0 20.0 ITGB7 0.029 0.046 0.263 24.0 -0.577 2.0 26.0 RAC1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.043 0.062 -9999.0 0.0 -0.339 19.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.029 0.054 -9999.0 0.0 -0.317 19.0 19.0 mol:GDP -0.013 0.093 0.269 7.0 -0.359 20.0 27.0 CDC42/GTP/IQGAP1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.005 0.088 0.27 1.0 -0.32 19.0 20.0 RAC1/GTP/IQGAP1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.013 0.048 0.178 37.0 -0.246 3.0 40.0 NME1 0.026 0.03 0.263 14.0 -9999.0 0.0 14.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.023 0.118 -9999.0 0.0 -0.418 44.0 44.0 regulation of cell-cell adhesion 0.003 0.042 -9999.0 0.0 -0.287 2.0 2.0 WASF2 0.007 0.027 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.012 0.06 0.246 1.0 -0.281 18.0 19.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.069 -9999.0 0.0 -0.322 21.0 21.0 CCND1 0.015 0.055 0.212 30.0 -0.311 3.0 33.0 VAV2 -0.019 0.15 -9999.0 0.0 -0.538 38.0 38.0 RAP1/GDP 0.006 0.071 0.264 3.0 -0.353 3.0 6.0 adherens junction assembly -0.022 0.115 -9999.0 0.0 -0.405 44.0 44.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.04 0.065 -9999.0 0.0 -0.312 21.0 21.0 E-cadherin/beta catenin -0.0 0.062 -9999.0 0.0 -0.347 29.0 29.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.024 0.119 -9999.0 0.0 -0.427 41.0 41.0 PIK3CA 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.005 0.091 0.268 29.0 -0.344 22.0 51.0 E-cadherin/beta catenin/alpha catenin 0.033 0.062 -9999.0 0.0 -0.369 19.0 19.0 ITGAE 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.023 0.127 -9999.0 0.0 -0.426 50.0 50.0