Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.016 0.138 0.428 71.0 -0.247 2.0 73.0 KIRREL -0.021 0.16 -9999.0 0.0 -0.581 73.0 73.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.016 0.138 0.248 2.0 -0.429 71.0 73.0 PLCG1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.036 0.116 0.288 4.0 -0.326 70.0 74.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.009 0.087 0.239 1.0 -0.287 58.0 59.0 FYN 0.017 0.13 0.276 104.0 -0.313 69.0 173.0 mol:Ca2+ 0.033 0.112 0.314 1.0 -0.324 67.0 68.0 mol:DAG 0.034 0.113 0.319 1.0 -0.325 67.0 68.0 NPHS2 0.014 0.031 0.27 4.0 -9999.0 0.0 4.0 mol:IP3 0.034 0.113 0.319 1.0 -0.325 67.0 68.0 regulation of endocytosis 0.024 0.103 0.245 5.0 -0.297 69.0 74.0 Nephrin/NEPH1/podocin/Cholesterol 0.025 0.111 0.253 9.0 -0.324 70.0 79.0 establishment of cell polarity 0.016 0.138 0.247 2.0 -0.428 71.0 73.0 Nephrin/NEPH1/podocin/NCK1-2 0.045 0.112 0.323 1.0 -0.302 68.0 69.0 Nephrin/NEPH1/beta Arrestin2 0.028 0.106 0.253 5.0 -0.3 69.0 74.0 NPHS1 0.06 0.092 0.265 152.0 -9999.0 0.0 152.0 Nephrin/NEPH1/podocin 0.026 0.11 0.307 4.0 -0.315 69.0 73.0 TJP1 0.023 0.02 -9999.0 0.0 -0.577 1.0 1.0 NCK1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.024 0.002 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.035 0.115 0.325 1.0 -0.327 67.0 68.0 CD2AP 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.033 0.114 0.298 5.0 -0.326 67.0 72.0 GRB2 0.023 0.01 0.263 1.0 -9999.0 0.0 1.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.015 0.136 0.29 97.0 -0.316 76.0 173.0 cytoskeleton organization 0.005 0.106 0.293 11.0 -0.338 54.0 65.0 Nephrin/NEPH1 0.017 0.102 0.191 7.0 -0.305 71.0 78.0 Nephrin/NEPH1/ZO-1 0.027 0.12 -9999.0 0.0 -0.352 71.0 71.0