Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.044 0.226 0.42 4.0 -0.639 105.0 109.0 IHH 0.014 0.082 0.268 27.0 -0.232 15.0 42.0 SHH Np/Cholesterol/GAS1 0.0 0.076 -9999.0 0.0 -0.335 44.0 44.0 LRPAP1 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.0 0.076 0.333 44.0 -9999.0 0.0 44.0 SMO/beta Arrestin2 -0.021 0.21 -9999.0 0.0 -0.612 90.0 90.0 SMO -0.044 0.212 -9999.0 0.0 -0.645 90.0 90.0 AKT1 -0.004 0.127 -9999.0 0.0 -0.516 26.0 26.0 ARRB2 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.019 0.154 -9999.0 0.0 -0.577 69.0 69.0 ADRBK1 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.043 0.208 -9999.0 0.0 -0.633 90.0 90.0 STIL 0.006 0.176 0.3 28.0 -0.491 76.0 104.0 DHH N/PTCH2 -0.012 0.146 -9999.0 0.0 -0.433 99.0 99.0 DHH N/PTCH1 -0.029 0.205 -9999.0 0.0 -0.5 133.0 133.0 PIK3CA 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.008 0.098 0.263 2.0 -0.577 26.0 28.0 PTHLH -0.066 0.306 0.432 11.0 -0.834 114.0 125.0 determination of left/right symmetry -0.043 0.208 -9999.0 0.0 -0.633 90.0 90.0 PIK3R1 0.02 0.047 -9999.0 0.0 -0.577 6.0 6.0 skeletal system development -0.065 0.301 0.431 11.0 -0.822 114.0 125.0 IHH N/Hhip 0.026 0.057 -9999.0 0.0 -0.468 2.0 2.0 DHH N/Hhip 0.022 0.079 -9999.0 0.0 -0.423 28.0 28.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.043 0.208 -9999.0 0.0 -0.633 90.0 90.0 pancreas development 0.023 0.034 0.262 7.0 -0.576 2.0 9.0 HHAT 0.02 0.021 -9999.0 0.0 -0.577 1.0 1.0 PI3K 0.031 0.036 -9999.0 0.0 -0.359 7.0 7.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.008 0.135 -9999.0 0.0 -0.577 52.0 52.0 somite specification -0.043 0.208 -9999.0 0.0 -0.633 90.0 90.0 SHH Np/Cholesterol/PTCH1 -0.026 0.161 0.28 2.0 -0.493 85.0 87.0 SHH Np/Cholesterol/PTCH2 -0.007 0.088 -9999.0 0.0 -0.336 59.0 59.0 SHH Np/Cholesterol/Megalin -0.059 0.149 0.281 3.0 -0.337 201.0 204.0 SHH -0.0 0.038 0.363 6.0 -0.432 1.0 7.0 catabolic process -0.034 0.207 0.346 1.0 -0.555 117.0 118.0 SMO/Vitamin D3 -0.01 0.2 0.355 15.0 -0.572 82.0 97.0 SHH Np/Cholesterol/Hhip 0.016 0.034 0.311 5.0 -0.341 3.0 8.0 LRP2 -0.12 0.267 0.263 25.0 -0.577 243.0 268.0 receptor-mediated endocytosis -0.08 0.224 0.305 9.0 -0.621 97.0 106.0 SHH Np/Cholesterol/BOC -0.005 0.087 -9999.0 0.0 -0.336 58.0 58.0 SHH Np/Cholesterol/CDO 0.012 0.042 -9999.0 0.0 -0.338 12.0 12.0 mesenchymal cell differentiation -0.015 0.034 0.339 3.0 -0.308 5.0 8.0 mol:Vitamin D3 0.001 0.183 0.344 19.0 -0.497 84.0 103.0 IHH N/PTCH2 -0.011 0.143 -9999.0 0.0 -0.463 78.0 78.0 CDON 0.014 0.067 -9999.0 0.0 -0.577 12.0 12.0 IHH N/PTCH1 -0.025 0.213 0.353 3.0 -0.558 117.0 120.0 Megalin/LRPAP1 -0.078 0.204 -9999.0 0.0 -0.427 243.0 243.0 PTCH2 -0.022 0.159 -9999.0 0.0 -0.577 74.0 74.0 SHH Np/Cholesterol 0.01 0.014 -9999.0 0.0 -0.337 1.0 1.0 PTCH1 -0.034 0.208 0.346 1.0 -0.557 117.0 118.0 HHIP 0.023 0.034 0.263 7.0 -0.577 2.0 9.0