Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.011 0.045 -9999.0 0.0 -0.263 20.0 20.0 epithelial cell differentiation 0.035 0.056 -9999.0 0.0 -0.317 19.0 19.0 CYFIP2 0.029 0.047 0.263 25.0 -0.577 2.0 27.0 ENAH -0.004 0.061 0.295 10.0 -9999.0 0.0 10.0 EGFR -0.192 0.288 -9999.0 0.0 -0.577 349.0 349.0 EPHA2 0.02 0.043 -9999.0 0.0 -0.577 5.0 5.0 MYO6 -0.013 0.052 0.361 1.0 -0.307 20.0 21.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.049 0.031 -9999.0 0.0 -0.369 1.0 1.0 AQP5 -0.191 0.263 0.333 1.0 -0.506 387.0 388.0 CTNND1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.013 0.051 0.358 1.0 -0.302 19.0 20.0 regulation of calcium-dependent cell-cell adhesion -0.024 0.076 0.358 1.0 -0.306 56.0 57.0 EGF -0.093 0.238 0.263 2.0 -0.577 189.0 191.0 NCKAP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.016 0.116 0.291 1.0 -0.467 47.0 48.0 cortical microtubule organization 0.035 0.056 -9999.0 0.0 -0.317 19.0 19.0 GO:0000145 -0.013 0.048 0.351 1.0 -0.289 19.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.04 0.058 -9999.0 0.0 -0.32 19.0 19.0 MLLT4 0.021 0.035 0.263 1.0 -0.577 3.0 4.0 ARF6/GDP -0.021 0.041 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.044 0.039 -9999.0 0.0 -0.336 5.0 5.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.002 0.05 -9999.0 0.0 -0.288 19.0 19.0 PVRL2 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.013 0.051 0.361 1.0 -0.306 19.0 20.0 ARF6/GTP 0.048 0.041 -9999.0 0.0 -0.315 5.0 5.0 CDH1 0.01 0.083 -9999.0 0.0 -0.577 19.0 19.0 EGFR/EGFR/EGF/EGF -0.15 0.201 -9999.0 0.0 -0.338 482.0 482.0 RhoA/GDP 0.036 0.055 -9999.0 0.0 -0.304 19.0 19.0 actin cytoskeleton organization -0.015 0.05 0.343 1.0 -0.299 20.0 21.0 IGF-1R heterotetramer 0.011 0.086 0.262 2.0 -0.576 20.0 22.0 GIT1 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.011 0.086 0.263 2.0 -0.577 20.0 22.0 IGF1 -0.101 0.244 -9999.0 0.0 -0.577 202.0 202.0 DIAPH1 0.026 0.101 -9999.0 0.0 -0.543 14.0 14.0 Wnt receptor signaling pathway -0.035 0.056 0.317 19.0 -9999.0 0.0 19.0 RHOA 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.021 0.042 -9999.0 0.0 -0.282 20.0 20.0 CTNNA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.015 0.051 0.346 1.0 -0.305 20.0 21.0 EFNA1 0.02 0.009 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.016 0.052 -9999.0 0.0 -0.296 24.0 24.0 Ephrin A1/EPHA2 0.024 0.056 -9999.0 0.0 -0.299 22.0 22.0 SEC6/SEC8 -0.022 0.044 -9999.0 0.0 -0.301 21.0 21.0 MGAT3 -0.024 0.077 0.361 1.0 -0.311 56.0 57.0 HGF/MET -0.041 0.157 -9999.0 0.0 -0.329 208.0 208.0 HGF -0.013 0.145 -9999.0 0.0 -0.577 60.0 60.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.011 0.045 -9999.0 0.0 -0.265 20.0 20.0 actin cable formation 0.041 0.096 0.311 35.0 -0.294 1.0 36.0 KIAA1543 -0.013 0.053 0.354 1.0 -0.321 19.0 20.0 KIFC3 -0.013 0.049 0.361 1.0 -0.307 19.0 20.0 NCK1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.013 0.05 -9999.0 0.0 -0.307 19.0 19.0 NCK1/GIT1 0.033 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.035 0.056 -9999.0 0.0 -0.317 19.0 19.0 EXOC4 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.013 0.05 0.361 1.0 -0.307 19.0 20.0 PIP5K1C -0.013 0.052 0.361 1.0 -0.307 19.0 20.0 LIMA1 0.023 0.027 -9999.0 0.0 -0.577 2.0 2.0 ABI1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.016 0.09 0.304 25.0 -9999.0 0.0 25.0 adherens junction assembly -0.023 0.103 0.298 3.0 -0.639 14.0 17.0 IGF-1R heterotetramer/IGF1 -0.043 0.151 -9999.0 0.0 -0.315 213.0 213.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.031 0.03 0.199 1.0 -0.303 6.0 7.0 MET -0.072 0.22 -9999.0 0.0 -0.577 155.0 155.0 PLEKHA7 -0.013 0.056 0.361 1.0 -0.337 19.0 20.0 mol:GTP 0.043 0.038 -9999.0 0.0 -0.334 5.0 5.0 establishment of epithelial cell apical/basal polarity -0.01 0.068 0.372 6.0 -0.524 1.0 7.0 cortical actin cytoskeleton stabilization 0.011 0.045 -9999.0 0.0 -0.263 20.0 20.0 regulation of cell-cell adhesion -0.015 0.05 0.343 1.0 -0.299 20.0 21.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.011 0.045 -9999.0 0.0 -0.265 20.0 20.0